Hub : Genes

LOC120100061

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr1_264792163_264792666 0.08 0.07 9.9e-03 0.04 0.03 0.03 0.05 1.2e-02 1.7e-02 1.7e-02 3.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1
Bone: apparent density2.95.35.3-2.3
Area under the delay curve1.01.61.6-1.3
BMI with tail11.239.239.2-6.3
BMI without tail3.619.019.0-4.4
Body weight12.655.255.2-7.4
Weight adjusted by age2.05.85.8-2.4
Bone surface1.12.22.2-1.5
Bone volume3.87.57.5-2.7
Breakpoint value in progressive ratio session1.12.02.0-1.4
Number of licking bursts0.92.72.7-1.6
Context. condit. distance diff. score1.01.21.21.1
Locomotion velocity, session 10.91.01.01.0
Locomotion distance, session 10.70.90.91.0
Locomotion velocity, session 22.32.82.81.7
Locomotion distance, session 21.11.61.6-1.3
Locomotion velocity, session 30.10.20.20.4
Locomotion distance, session 30.30.30.30.5
Stereotopy head waving bouts, day 30.10.10.1-0.3
Stereotopy head waving duration, day 30.10.10.10.3
Locomotion velocity, session 70.10.10.1-0.3
Locomotion distance, session 70.20.20.20.5
Stereotopy head waving bouts, day 70.10.20.2-0.4
Stereotopy head waving duration, day 70.91.11.1-1.1
Locomotion velocity, session 82.32.82.81.7
Locomotion distance, session 80.50.70.70.9
Degree of sensitization distance0.00.00.00.1
Degree of sensitization stereotypy0.40.40.4-0.7
Conditioned locomotion0.10.10.10.4
Cocaine response after cond. corrected1.92.82.81.7
Cocaine response after cond. not corrected2.94.24.22.1
Cocaine response before conditioning0.10.20.20.4
Saline control response1.42.02.01.4
Bone: connectivity density0.00.00.0-0.1
Bone: cortical apparent density4.87.67.62.8
Bone: cortical area10.817.617.6-4.2
Bone: cortical porosity0.20.20.2-0.4
Bone: cortical porosity1.11.21.2-1.1
Bone: cortical thickness4.16.96.9-2.6
Bone: cortical thickness1.51.81.8-1.3
Bone: cortical tissue density5.28.28.22.9
Condit. Reinf. active minus inactive responses0.00.00.00.1
Condit. Reinf. active-inactive response ratio0.20.20.20.5
Condit. Reinf. active responses0.40.50.5-0.7
Condit. Reinf. inactive responses1.21.51.5-1.2
Incentive salience index mean0.40.50.50.7
Condit. Reinf. lever presses0.30.50.50.7
Condit. Reinf. active minus inactive responses1.52.22.2-1.5
Condit. Reinf. active-inactive response ratio0.30.40.4-0.7
Condit. Reinf. active responses3.34.74.7-2.2
Condit. Reinf. inactive responses1.21.71.7-1.3
Condit. Reinf. lever presses1.52.12.1-1.5
Condit. Reinf. lever reinforcers received2.83.93.9-2.0
Conditioned reinforcement - actives0.00.20.2-0.4
Conditioned reinforcement - inactives0.61.51.5-1.2
Conditioned locomotion0.00.00.00.2
Patch foraging indifference point 0 sec2.26.26.2-2.5
Patch foraging indifference point AUC0.71.61.6-1.3
Delay disc. indifference point, 0s delay1.11.31.3-1.1
Delay disc. indifference point, 16s delay0.40.50.5-0.7
Delay disc. indifference point, 2s delay0.00.00.0-0.0
Delay disc. indifference point, 24s delay1.52.42.4-1.5
Delay disc. indifference point, 4s delay0.20.20.2-0.4
Delay disc. indifference point, 8s delay3.25.45.4-2.3
Indifference point function ln k0.30.90.90.9
Indifference point function log k0.30.90.90.9
Patch foraging total patch changes 0 sec2.36.66.6-2.6
Patch foraging total patch changes 12 sec2.63.43.4-1.8
Patch foraging total patch changes 18 sec3.48.18.1-2.8
Patch foraging total patch changes 24 sec1.44.64.6-2.2
Patch foraging total patch changes 6 sec6.310.610.6-3.3
Patch foraging time to switch 0 sec0.31.31.31.1
Patch foraging water rate 0 sec0.20.70.7-0.9
Patch foraging water rate 12 sec0.41.61.6-1.3
Patch foraging water rate 18 sec0.30.60.6-0.8
Patch foraging water rate 24 sec2.23.13.1-1.8
Patch foraging water rate 6 sec0.10.10.1-0.4
Seeking ratio, delayed vs. immediate footshock0.10.10.10.3
Distance traveled before self-admin1.22.72.71.6
Distance traveled after self-admin0.10.10.10.4
Extensor digitorum longus weight0.51.81.8-1.4
Bone: elastic displacement0.10.10.1-0.3
Bone: elastic work0.40.50.5-0.7
Bone: endosteal estimation2.76.76.7-2.6
Bone: endosteal perimeter4.912.012.0-3.5
Epididymis fat weight9.447.347.3-6.9
Delta time in closed arm before/after self-admin0.00.00.00.2
Delta time in open arm before/after self-admin1.41.71.7-1.3
Diff in mean of infusions in LGA sessions0.81.41.41.2
Delay discount exponential model param1.31.81.81.3
Extinction: sum of active levers before priming0.10.10.1-0.3
Active lever presses in extinction session 60.60.60.6-0.8
Bone: final force2.54.14.1-2.0
Bone: final moment3.25.25.2-2.3
Food consumed during 24 hour testing period0.00.00.00.0
Glucose0.40.60.6-0.8
Heart weight3.35.45.4-2.3
Delay discount hyperbolic model param1.11.41.41.2
Intermittent access intake day 1-15 change0.31.91.9-1.4
Intermittent access intake escalation0.42.02.0-1.4
Intermittent access intake escalation 20.40.60.6-0.8
Intermitt. access day 1 inactive lever presses0.55.85.8-2.4
Intermitt. access day 15 inactive lever presses0.10.60.6-0.7
Intermitt. access escalation Index0.00.00.0-0.1
Intermittent access day 1 total infusions0.41.31.3-1.1
Intermittent access day 15 total infusions0.71.71.7-1.3
Intermittent access terminal intake (last 3 days)0.50.80.8-0.9
Intermittent access total infusions1.72.12.1-1.4
Intermittent access day 1 locomotion0.10.20.2-0.5
Intermittent access day 15 total locomotion0.72.92.9-1.7
Intermittent access total locomotion0.10.10.1-0.4
Intermittent access standard deviation0.42.02.0-1.4
Left kidney weight0.75.85.8-2.4
Right kidney weight1.39.49.4-3.1
Cocaine induced anxiety1.74.74.72.2
Post-drug Anxiety0.10.10.10.3
Baseline Anxiety2.54.24.2-2.1
Tail length0.21.21.2-1.1
Length with tail1.77.77.7-2.8
Length without tail3.618.718.7-4.3
Times rat made contact with spout1.01.21.2-1.1
Lifetime Intake1.92.42.4-1.6
Liver weight, left6.611.411.4-3.4
Liver weight, right6.511.411.4-3.4
Locomotor activity0.20.30.3-0.5
Locomotor testing distance0.00.00.0-0.2
Locomotor testing rearing0.10.30.3-0.5
Locomotion in novel chamber0.30.40.40.6
Locomotion in novel chamber post-restriction0.82.32.31.5
Fecal boli incidents, locomotor time 10.00.00.0-0.1
Change in fecal boli incidents, locomotor task0.20.20.20.5
Time >=10cm from walls, locomotor time 11.31.61.61.3
Bouts of movement, locomotor time 13.54.54.5-2.1
Total resting periods, locomotor time 13.64.14.1-2.0
Rest time, locomotor task time 10.40.60.6-0.8
Distance moved, locomotor task time 10.00.10.10.2
Vertical activity count, locomotor time 10.32.22.21.5
Time >=10cm from walls, locomotor time 20.30.80.8-0.9
Bouts of movement, locomotor time 20.20.60.60.8
Total resting periods, locomotor time 20.00.20.20.4
Rest time, locomotor task time 20.10.20.20.4
Distance moved, locomotor task time 20.50.60.6-0.8
Vertical activity count, locomotor time 20.10.30.3-0.5
Light reinforcement 10.31.31.31.1
Light reinforcement 20.92.02.01.4
Bone: marrow area2.76.76.7-2.6
Bone: maximum diameter10.120.320.3-4.5
Bone: maximum force1.63.13.1-1.8
Bone: maximum moment2.13.93.9-2.0
Mean time between licks in bursts0.10.40.4-0.6
Mean num. licks in bursts0.20.50.50.7
Cd content in liver1.61.81.81.4
Co content in liver2.83.33.31.8
Cu content in liver0.20.30.30.5
Fe content in liver1.31.61.6-1.3
K content in liver0.80.70.70.9
Mg content in liver0.10.10.10.2
Mn content in liver0.20.20.20.4
Na content in liver0.40.50.50.7
Rb content in liver0.50.60.60.8
Se content in liver1.31.61.61.3
Sr content in liver3.73.23.21.8
Zn content in liver1.51.81.81.3
Bone: minimum diameter6.111.711.7-3.4
Time in familiar zone, hab. session 11.31.51.51.2
Time in novel zone, hab. session 12.52.82.8-1.7
Total zone transitions, hab. session 10.91.31.3-1.1
Total locomotion distance, hab. session 10.10.20.2-0.5
Locomotion velocity, hab. session 10.10.10.1-0.3
Time in familiar zone, hab. session 25.66.36.3-2.5
Time in novel zone, hab. session 22.72.92.91.7
Total zone transitions, hab. session 21.82.32.3-1.5
Total locomotion distance, hab. session 21.11.41.4-1.2
Locomotion velocity, hab. session 20.50.70.7-0.8
Novel to familiar place preference ratio0.10.10.1-0.3
Novelty place preference0.20.30.3-0.5
Time in novel zone, NPP test0.91.11.1-1.1
Total zone transitions, NPP test2.33.43.4-1.8
Total locomotion distance, NPP test1.92.62.6-1.6
Locomotion velocity, NPP test0.60.80.8-0.9
Intraocular pressure5.79.39.3-3.1
Delta distance traveled before/after self-admin1.41.51.5-1.2
Delta ambulatory time before/after self-admin1.52.62.6-1.6
Parametrial fat weight16.338.438.4-6.2
Pavlov. Cond. lever latency0.81.11.1-1.0
Pavlov. Cond. magazine entry latency0.20.20.2-0.5
Pavlov. Cond. change in total contacts0.10.10.10.3
Pavlov. Cond. index score0.00.00.00.0
Pavlov. Cond. latency score0.00.00.00.1
Pavlov. Cond. lever contacts0.80.90.91.0
Pavlov. Cond. magazine entry number0.40.50.50.7
Pavlov. Cond. intertrial magazine entries0.30.40.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.1
Pavlov. Cond. response bias0.10.10.10.3
Pavlov. Cond. lever latency1.31.81.81.4
Pavlov. Cond. magazine entry latency2.13.03.0-1.7
Pavlov. Cond. change in total contacts1.33.33.3-1.8
Pavlov. Cond. index score2.53.93.9-2.0
Pavlov. Cond. latency score2.54.04.0-2.0
Pavlov. Cond. lever contacts1.11.61.6-1.3
Pavlov. Cond. magazine entry number2.12.72.71.6
Pavlov. Cond. intertrial magazine entries0.00.10.1-0.3
Pavlov. Cond. lever-magazine prob. diff.2.43.73.7-1.9
Pavlov. Cond. response bias1.92.62.6-1.6
Time in closed arm before self-admin0.10.20.20.4
Time in closed arm after self-admin0.50.60.60.7
Time in open arm before self-admin1.01.21.21.1
Time in open arm after self-admin0.30.40.4-0.6
Bone: periosteal estimation7.116.916.9-4.1
Bone: periosteal perimeter10.420.620.6-4.5
Bone: post-yield work0.40.60.6-0.8
Progressive ratio test 1 active lever presses1.62.82.8-1.7
Progressive ratio test 1 breakpoint1.52.62.6-1.6
Progressive ratio test 1 inactive lever presses0.82.22.2-1.5
Progressive ratio test 2 active lever presses2.23.13.1-1.8
Progressive ratio test 2 breakpoint2.53.23.2-1.8
Progressive ratio test 2 inactive lever presses0.82.42.4-1.6
Incentive Sensitization - Responses0.51.41.4-1.2
Incentive Sensitization - Breakpoint0.51.21.2-1.1
Sum of active levers in priming session hrs 5-60.50.50.50.7
Progressive ratio0.10.30.30.5
Food seeking constrained by brief footshock0.00.00.0-0.2
Seeking ratio, punishment vs. effort0.10.30.3-0.6
Retroperitoneal fat weight14.765.765.7-8.1
Reaction time number correct0.51.81.8-1.4
Reaction time mean minus median0.10.50.5-0.7
Reaction time mean minus median AUC0.00.30.3-0.5
Reaction time num false alarms0.00.00.0-0.1
Reaction time num false alarms AUC0.00.00.00.0
Reaction time trials correct on left0.51.81.8-1.4
Reaction time trials on left0.62.02.0-1.4
Reaction time mean0.00.10.10.3
Reaction time mean AUC0.10.30.30.6
Median of all reaction times0.30.40.40.6
Reaction time omissions0.50.80.8-0.9
Reaction time false alarm rate0.20.30.30.6
Reaction time premature initiation rate0.00.00.00.1
Reaction time premature initiations0.20.60.6-0.8
Std. dev. reaction times0.51.61.6-1.3
Reaction time trials completed0.62.02.0-1.4
Reaction time trials AUC0.62.22.2-1.5
Run reversals in cocaine runway, females0.50.50.5-0.7
Run reversals in cocaine runway, males0.50.60.60.8
Latency to leave start box in cocaine runway1.01.41.41.2
Latency to leave start box in cocaine runway, F1.72.12.11.5
Latency to leave start box in cocaine runway, M0.10.10.1-0.4
Std. dev. time between licks in bursts0.30.60.6-0.8
Total sessions with >9 infusions3.03.83.8-1.9
Short access day 1 total inactive lever presses0.91.81.8-1.4
Short access day 10 total inactive lever presses0.10.60.6-0.8
Short access day 1 total infusions0.30.60.6-0.8
Short access day 10 total infusions0.00.10.1-0.3
Short access total infusions0.71.01.0-1.0
Short access day 1 locomotion0.71.21.2-1.1
Short access day 10 total locomotion0.00.20.2-0.4
Short access total locomotion0.50.70.7-0.8
One hour access (0.3 mA shock)3.64.24.2-2.1
Compulsive drug intake0.50.80.8-0.9
One hour access (shock baseline)0.30.80.8-0.9
Social response proportion0.40.60.6-0.8
Social responses5.26.96.9-2.6
Social time0.30.40.4-0.7
Soleus weight2.06.06.0-2.4
Bone: stiffness0.30.50.5-0.7
Tibialis anterior weight0.00.00.0-0.2
Time to tail flick, vehicle, before self-admin0.30.30.3-0.6
Time to tail flick, vehicle, after self-admin0.10.20.20.5
Time to tail flick, test, before self-admin0.20.30.30.5
Time to tail flick, test, after self-admin1.31.31.3-1.2
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.0
Delta time to tail flick, test, before/after SA0.50.60.6-0.8
Tibia length1.02.62.6-1.6
Ambulatory time before self-admin0.30.80.80.9
Ambulatory time after self-admin0.00.00.00.2
Bone: tissue strength0.20.20.20.4
Total heroin consumption4.25.05.0-2.2
Bone: trabecular number0.81.61.6-1.3
Bone: trabecular spacing0.10.20.20.4
Bone: trabecular thickness7.210.010.0-3.2
Bone: trabecular tissue density0.10.20.20.5
Water consumed over 24 hours0.10.20.2-0.4
Number of responses in last shaping day0.00.00.0-0.2