Hub : Genes

LOC120100032

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	isoform ratio	XR_010063256.1	0.15	0.09	3.9e-12	0.07	0.07	0.06	0.07	2.1e-08	2.4e-08	1.9e-07	3.3e-08
2	Liver	intron excision ratio	chr1_248224530_248236789	0.07	0.05	3.0e-05	0.03	0.03	0.02	0.02	4.2e-04	5.6e-04	4.1e-03	1.5e-03
3	Liver	isoform ratio	XR_010063259.1	0.42	0.17	0.0e+00	0.31	0.31	0.32	0.32	4.8e-35	1.8e-35	4.8e-36	4.8e-36
4	Liver	gene expression	LOC120100032	0.29	0.15	0.0e+00	0.18	0.18	0.18	0.18	7.6e-20	7.6e-20	6.6e-20	1.8e-19
5	Liver	intron excision ratio	chr1_248215262_248224055	0.36	0.13	0.0e+00	0.19	0.21	0.2	0.2	7.0e-21	1.7e-22	5.3e-22	2.8e-22
6	Liver	intron excision ratio	chr1_248215262_248224428	0.22	0.12	6.9e-14	0.12	0.11	0.11	0.12	7.6e-13	2.6e-12	4.0e-12	6.8e-13
7	Liver	intron excision ratio	chr1_248215262_248221960	0.38	0.16	0.0e+00	0.28	0.3	0.31	0.3	3.5e-31	2.7e-33	1.4e-34	1.9e-33
8	Liver	intron excision ratio	chr1_248224530_248236693	0.06	0.04	1.5e-03	0.03	0.02	0.02	0.02	7.5e-04	1.3e-03	4.3e-03	1.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8
Bone: apparent density	0.7	1.4	2.2	-1.1	-1.0	1.5	1.5	0.5	-1.2	1.2	1.1
Area under the delay curve	1.0	1.5	3.4	1.5	1.3	-0.3	-0.4	-1.8	-1.5	-0.7	1.3
BMI with tail	0.6	2.2	4.1	-1.0	-0.9	2.0	2.0	0.2	-1.7	1.5	1.7
BMI without tail	0.1	0.3	0.6	-0.2	-0.3	0.7	0.8	-0.0	-0.6	0.4	0.6
Body weight	0.2	0.9	2.1	-1.1	-1.2	0.1	0.4	1.5	1.1	0.5	-1.1
Weight adjusted by age	0.3	0.9	1.8	-0.5	-0.4	1.3	1.2	-0.1	-1.1	0.9	1.3
Bone surface	1.1	2.1	3.5	-1.7	-1.6	1.7	1.9	1.1	-0.9	1.5	0.8
Bone volume	1.1	2.2	3.6	-1.9	-1.8	1.6	1.8	1.4	-0.6	1.6	0.5
Breakpoint value in progressive ratio session	0.4	0.8	1.4	1.0	1.0	-1.2	-1.1	-0.7	0.2	-1.1	-0.6
Number of licking bursts	0.8	2.3	5.1	1.9	2.0	-0.4	-0.6	-2.3	-1.4	-1.1	1.4
Context. condit. distance diff. score	0.2	0.2	0.4	-0.5	-0.6	0.4	0.4	0.5	0.1	0.6	0.1
Locomotion velocity, session 1	3.2	3.6	7.4	2.6	2.6	-1.0	-1.4	-2.7	-1.2	-1.5	1.3
Locomotion distance, session 1	1.2	1.5	2.7	1.6	1.7	-1.1	-1.3	-1.5	-0.3	-1.3	0.3
Locomotion velocity, session 2	0.9	1.0	2.2	1.2	1.5	-0.5	-0.5	-1.4	-0.8	-1.0	0.7
Locomotion distance, session 2	0.4	0.6	1.4	1.1	1.0	-0.2	-0.5	-1.2	-0.6	-0.4	0.8
Locomotion velocity, session 3	0.4	0.5	1.2	0.1	0.1	-0.8	-0.8	0.4	1.1	-0.5	-1.1
Locomotion distance, session 3	2.0	2.2	6.2	-0.5	-0.5	-1.5	-1.0	1.4	2.4	-0.7	-2.5
Stereotopy head waving bouts, day 3	0.1	0.2	0.3	0.5	0.5	-0.1	-0.5	-0.6	-0.4	-0.2	0.3
Stereotopy head waving duration, day 3	0.5	0.6	1.4	0.8	0.8	0.2	-0.2	-1.2	-1.0	-0.2	1.0
Locomotion velocity, session 7	0.5	0.6	1.3	-0.9	-1.1	0.3	0.2	1.1	0.7	0.8	-0.5
Locomotion distance, session 7	0.9	1.1	2.5	-1.2	-1.6	0.6	0.6	1.4	0.8	1.2	-0.5
Stereotopy head waving bouts, day 7	1.7	2.0	3.6	1.9	1.9	-1.3	-1.4	-1.7	-0.2	-1.5	0.1
Stereotopy head waving duration, day 7	0.8	0.9	1.9	1.2	1.4	-0.9	-0.9	-1.1	-0.2	-1.2	0.0
Locomotion velocity, session 8	0.0	0.1	0.2	0.3	0.2	-0.2	-0.4	-0.1	0.2	-0.1	-0.0
Locomotion distance, session 8	0.2	0.2	0.8	0.4	0.2	0.4	-0.0	-0.6	-0.6	0.3	0.9
Degree of sensitization distance	1.2	1.3	3.9	0.3	0.1	1.3	0.8	-0.9	-1.7	0.8	2.0
Degree of sensitization stereotypy	2.0	2.2	3.8	1.9	1.9	-1.5	-1.5	-1.7	0.1	-1.7	-0.1
Conditioned locomotion	1.0	1.1	2.1	-1.4	-1.5	1.1	1.1	1.2	-0.0	1.2	0.0
Cocaine response after cond. corrected	0.1	0.1	0.3	0.3	0.2	0.1	0.1	-0.5	-0.5	-0.0	0.5
Cocaine response after cond. not corrected	0.2	0.3	0.5	0.5	0.5	-0.7	-0.5	-0.4	0.3	-0.7	-0.3
Cocaine response before conditioning	1.3	1.6	3.0	1.0	1.1	-1.7	-1.6	-0.4	1.2	-1.5	-1.2
Saline control response	1.7	2.3	3.6	1.6	1.7	-1.9	-1.9	-1.2	0.6	-1.8	-0.7
Bone: connectivity density	2.0	3.1	5.4	-1.7	-1.5	2.3	2.3	0.8	-1.6	1.8	1.6
Bone: cortical apparent density	0.9	1.4	3.2	1.5	1.5	-0.4	-0.5	-1.8	-1.0	-0.9	1.0
Bone: cortical area	1.2	1.9	4.2	-1.5	-1.7	-0.3	0.0	2.1	1.7	0.5	-1.7
Bone: cortical porosity	1.7	1.8	4.7	0.5	0.5	1.4	1.0	-1.3	-2.2	0.6	2.1
Bone: cortical porosity	0.8	0.9	2.1	0.1	0.2	1.1	0.9	-0.7	-1.5	0.6	1.4
Bone: cortical thickness	1.4	2.4	4.7	0.7	0.6	-2.2	-1.9	0.2	2.0	-1.6	-1.9
Bone: cortical thickness	2.2	2.7	4.0	1.9	2.0	-1.9	-1.9	-1.5	0.5	-2.0	-0.5
Bone: cortical tissue density	1.0	1.5	3.7	1.5	1.6	-0.2	-0.3	-1.9	-1.3	-0.8	1.2
Condit. Reinf. active minus inactive responses	0.3	0.4	0.6	0.5	0.6	-0.8	-0.8	-0.2	0.5	-0.7	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.1	0.2	-0.5	-0.4	0.2	0.5	-0.4	-0.5
Condit. Reinf. active responses	0.2	0.3	0.5	0.3	0.4	-0.7	-0.6	-0.0	0.5	-0.6	-0.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.5	0.5	-0.2	-0.2	-0.5	-0.2	-0.3	0.2
Incentive salience index mean	0.6	0.8	1.4	0.5	0.5	-1.2	-1.2	0.0	1.0	-0.9	-1.1
Condit. Reinf. lever presses	0.5	0.8	1.8	0.8	0.7	-1.2	-1.4	-0.3	0.8	-0.9	-0.8
Condit. Reinf. active minus inactive responses	1.3	2.0	3.1	-1.7	-1.8	1.5	1.6	1.4	-0.3	1.7	0.4
Condit. Reinf. active-inactive response ratio	0.9	1.4	2.5	-1.1	-1.2	1.6	1.5	0.7	-0.9	1.5	0.8
Condit. Reinf. active responses	0.9	1.3	3.1	-1.4	-1.5	0.2	0.5	1.8	1.2	0.7	-1.1
Condit. Reinf. inactive responses	1.9	2.8	7.0	-0.1	-0.1	-2.0	-1.5	1.1	2.6	-1.2	-2.5
Condit. Reinf. lever presses	0.5	0.7	1.5	0.3	0.3	-1.2	-1.0	0.2	1.2	-0.8	-1.1
Condit. Reinf. lever reinforcers received	0.5	0.8	1.7	-1.0	-1.0	-0.2	0.1	1.3	1.1	0.4	-1.0
Conditioned reinforcement - actives	0.1	0.4	0.7	0.6	0.5	-0.7	-0.8	-0.5	0.7	-0.6	-0.5
Conditioned reinforcement - inactives	0.2	0.6	1.0	0.8	1.0	-0.8	-0.9	-0.9	0.1	-0.9	-0.2
Conditioned locomotion	0.3	0.5	0.9	0.6	0.4	-0.9	-0.8	-0.2	1.0	-0.6	-0.7
Patch foraging indifference point 0 sec	0.2	0.7	1.5	0.2	0.3	-1.0	-0.9	0.3	1.1	-0.6	-1.2
Patch foraging indifference point AUC	2.1	4.9	7.4	2.7	2.7	-2.5	-2.3	-2.2	0.8	-2.7	-0.5
Delay disc. indifference point, 0s delay	1.4	1.6	3.8	-0.5	-0.6	1.4	1.4	-0.3	-1.9	1.0	1.8
Delay disc. indifference point, 16s delay	0.6	0.8	1.8	1.2	1.1	-0.5	-0.6	-1.3	-0.6	-0.7	0.6
Delay disc. indifference point, 2s delay	1.1	1.2	3.6	0.4	0.4	0.9	0.7	-1.1	-1.8	0.3	1.9
Delay disc. indifference point, 24s delay	1.8	2.8	4.9	2.2	2.2	-1.6	-1.6	-2.0	-0.1	-1.9	0.1
Delay disc. indifference point, 4s delay	0.9	1.0	2.3	1.1	0.9	-0.1	-0.2	-1.4	-1.5	-0.4	1.1
Delay disc. indifference point, 8s delay	1.7	2.8	5.8	2.2	2.1	-1.0	-1.1	-2.4	-1.2	-1.5	1.1
Indifference point function ln k	1.4	4.2	6.3	-2.5	-2.5	2.3	2.3	2.0	-0.6	2.5	0.5
Indifference point function log k	1.4	4.2	6.3	-2.5	-2.5	2.3	2.3	2.0	-0.6	2.5	0.5
Patch foraging total patch changes 0 sec	0.3	0.8	1.9	0.1	0.2	-1.0	-0.9	0.4	1.3	-0.6	-1.4
Patch foraging total patch changes 12 sec	3.1	4.2	6.4	2.4	2.4	-2.4	-2.5	-1.9	0.7	-2.3	-0.6
Patch foraging total patch changes 18 sec	0.7	1.7	3.0	1.7	1.7	-1.2	-1.5	-1.5	-0.1	-1.3	-0.0
Patch foraging total patch changes 24 sec	0.3	1.2	1.9	0.8	0.8	-1.4	-1.2	-0.2	1.3	-1.2	-1.2
Patch foraging total patch changes 6 sec	3.4	5.7	8.8	2.6	2.6	-3.0	-2.8	-1.7	1.5	-2.9	-1.4
Patch foraging time to switch 0 sec	0.3	1.0	2.0	1.1	1.1	-0.1	-0.5	-1.4	-1.3	-0.5	1.0
Patch foraging water rate 0 sec	0.2	0.9	1.6	-1.2	-1.2	0.5	0.7	1.3	0.8	0.8	-0.5
Patch foraging water rate 12 sec	0.1	0.5	1.1	-0.6	-0.8	0.1	0.1	0.9	1.0	0.4	-0.8
Patch foraging water rate 18 sec	0.2	0.4	0.7	-0.7	-0.7	0.2	0.2	0.9	0.8	0.4	-0.5
Patch foraging water rate 24 sec	0.2	0.3	0.5	-0.7	-0.7	0.4	0.7	0.6	0.2	0.5	-0.1
Patch foraging water rate 6 sec	0.0	0.0	0.1	-0.2	-0.2	0.2	0.3	0.1	-0.1	0.2	0.2
Seeking ratio, delayed vs. immediate footshock	0.4	0.6	2.0	-0.3	-0.4	-0.7	-0.5	0.8	0.8	-0.3	-1.4
Distance traveled before self-admin	0.1	0.2	0.5	-0.0	-0.1	0.5	0.5	-0.2	-0.7	0.3	0.7
Distance traveled after self-admin	0.5	0.9	2.0	-0.7	-0.7	1.4	1.3	0.3	-0.7	1.0	1.0
Extensor digitorum longus weight	0.1	0.4	1.2	-0.9	-0.6	0.7	1.1	0.6	-0.2	0.5	0.1
Bone: elastic displacement	1.0	1.3	3.0	-0.3	-0.1	1.5	1.1	-0.5	-1.7	0.9	1.7
Bone: elastic work	0.5	0.7	1.5	-0.4	-0.3	1.1	0.8	-0.2	-1.1	0.8	1.2
Bone: endosteal estimation	2.0	5.0	8.0	-2.6	-2.8	2.5	2.5	2.1	-0.7	2.6	0.6
Bone: endosteal perimeter	2.0	4.8	8.1	-2.7	-2.9	2.4	2.3	2.2	-0.5	2.6	0.4
Epididymis fat weight	0.8	3.9	5.7	-2.4	-2.3	2.2	2.4	1.8	-0.8	2.3	0.6
Delta time in closed arm before/after self-admin	0.5	0.5	1.7	-0.1	-0.2	-0.6	-0.6	0.5	1.3	-0.2	-1.0
Delta time in open arm before/after self-admin	0.7	0.9	2.2	-0.4	-0.4	1.2	1.1	-0.1	-1.5	0.7	1.2
Diff in mean of infusions in LGA sessions	0.2	0.3	0.4	-0.7	-0.6	0.6	0.6	0.5	-0.3	0.7	0.3
Delay discount exponential model param	1.1	1.5	3.3	-1.5	-1.4	0.4	0.5	1.8	1.3	0.8	-1.2
Extinction: sum of active levers before priming	0.1	0.2	0.7	-0.1	0.1	-0.3	-0.3	0.4	0.5	-0.2	-0.9
Active lever presses in extinction session 6	2.0	2.0	5.7	-0.1	0.1	1.3	1.4	-0.9	-2.4	0.6	2.4
Bone: final force	0.2	0.3	0.7	-0.4	-0.6	-0.2	-0.1	0.8	0.8	0.1	-0.8
Bone: final moment	0.3	0.4	0.9	-0.6	-0.9	-0.0	0.1	1.0	0.8	0.3	-0.8
Food consumed during 24 hour testing period	0.6	1.3	2.3	0.9	1.1	-1.5	-1.2	-0.4	1.0	-1.4	-1.0
Glucose	0.4	0.7	1.9	-0.5	-0.5	-0.5	-0.3	1.0	1.4	-0.1	-1.3
Heart weight	0.9	1.4	3.1	-1.2	-1.3	-0.1	0.3	1.8	1.4	0.6	-1.6
Delay discount hyperbolic model param	0.9	1.2	2.6	-1.3	-1.1	0.2	0.3	1.6	1.4	0.6	-1.3
Intermittent access intake day 1-15 change	0.2	1.0	2.2	-1.3	-1.5	0.9	1.0	1.1	0.3	1.1	0.1
Intermittent access intake escalation	0.3	1.5	3.1	-1.5	-1.8	1.2	1.3	1.3	0.1	1.4	0.1
Intermittent access intake escalation 2	0.7	1.1	2.4	-1.0	-1.5	1.2	0.9	1.0	-0.2	1.5	0.5
Intermitt. access day 1 inactive lever presses	0.0	0.5	1.1	-0.5	-0.2	0.6	1.0	-0.2	-1.0	0.2	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.6	-0.8	-0.7	0.3	0.5	0.8	0.3	0.4	-0.3
Intermitt. access escalation Index	0.1	0.4	0.8	-0.9	-0.7	0.4	0.5	0.8	0.3	0.5	-0.2
Intermittent access day 1 total infusions	0.0	0.1	0.3	0.3	0.3	0.0	0.1	-0.5	-0.4	-0.0	0.4
Intermittent access day 15 total infusions	0.5	1.2	2.2	-1.4	-1.4	0.6	0.7	1.5	1.0	1.1	-0.8
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.6	-0.8	-0.8	0.3	0.4	0.7	0.7	0.6	-0.4
Intermittent access total infusions	0.1	0.1	0.2	-0.4	-0.4	0.2	0.4	0.4	0.5	0.3	-0.2
Intermittent access day 1 locomotion	0.2	0.4	0.7	-0.8	-0.7	0.6	0.7	0.7	-0.2	0.8	-0.1
Intermittent access day 15 total locomotion	0.1	0.5	1.1	1.1	0.7	-0.6	-0.8	-0.8	-0.1	-0.5	0.2
Intermittent access total locomotion	0.2	0.2	0.6	0.4	0.4	0.1	0.1	-0.6	-0.8	-0.0	0.7
Intermittent access standard deviation	0.1	0.3	0.7	-0.4	-0.7	-0.0	0.2	0.8	0.8	0.5	-0.5
Left kidney weight	0.2	1.6	3.8	0.4	0.6	-1.6	-0.8	0.3	1.9	-1.4	-1.7
Right kidney weight	0.3	2.0	4.3	0.7	0.8	-1.8	-1.2	0.2	1.9	-1.5	-2.1
Cocaine induced anxiety	0.4	1.2	2.2	-1.2	-1.0	1.5	1.4	0.6	-0.7	1.1	0.9
Post-drug Anxiety	1.3	1.4	2.3	-1.5	-1.3	1.5	1.4	1.1	-0.3	1.4	0.3
Baseline Anxiety	0.3	0.5	1.2	-0.7	-0.5	-0.0	-0.1	1.0	1.0	0.3	-1.1
Tail length	0.2	1.2	3.3	-0.4	-0.5	-1.0	-0.8	1.1	1.8	-0.4	-1.8
Length with tail	0.7	3.2	8.2	-0.0	0.0	-2.1	-1.7	1.1	2.8	-1.2	-2.9
Length without tail	0.2	1.1	2.9	-0.0	-0.0	-1.2	-0.9	0.7	1.7	-0.7	-1.7
Times rat made contact with spout	0.2	0.2	0.4	0.5	0.6	-0.2	-0.3	-0.6	-0.4	-0.3	0.4
Lifetime Intake	0.1	0.1	0.3	-0.4	-0.3	0.3	0.5	0.2	0.1	0.3	0.1
Liver weight, left	0.1	0.1	0.2	-0.3	-0.2	-0.3	0.2	0.4	0.4	-0.3	-0.5
Liver weight, right	0.3	0.6	1.0	-1.0	-1.0	0.6	0.6	1.0	0.3	0.8	-0.4
Locomotor activity	0.1	0.2	0.5	0.3	0.2	-0.4	-0.6	-0.0	0.7	-0.3	-0.3
Locomotor testing distance	0.1	0.2	0.5	0.3	0.3	-0.5	-0.6	-0.1	0.7	-0.3	-0.4
Locomotor testing rearing	0.1	0.4	1.1	-0.5	-0.7	0.8	0.5	0.4	-0.3	1.1	0.3
Locomotion in novel chamber	2.7	3.6	6.8	-1.6	-1.7	2.6	2.2	0.9	-1.9	2.3	1.3
Locomotion in novel chamber post-restriction	0.1	0.3	0.5	0.5	0.3	-0.7	-0.7	-0.1	0.7	-0.7	-0.7
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.1	0.3	0.3	0.3	-0.5	-0.4	0.0	0.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.7	-0.1	0.0	-0.4	-0.3	0.5	0.5	-0.3	-0.9
Time >=10cm from walls, locomotor time 1	3.0	3.7	9.8	0.5	0.6	-2.2	-2.0	0.8	3.1	-1.4	-2.8
Bouts of movement, locomotor time 1	1.0	1.3	2.7	1.7	1.6	-0.4	-0.7	-1.6	-0.9	-0.9	0.8
Total resting periods, locomotor time 1	1.9	2.2	4.6	2.1	2.0	-1.0	-1.3	-1.9	-0.5	-1.4	0.5
Rest time, locomotor task time 1	0.8	1.3	3.1	1.5	1.2	0.1	-0.3	-1.8	-1.1	-0.7	1.5
Distance moved, locomotor task time 1	0.8	2.2	5.8	-1.1	-1.0	-0.8	-0.6	2.0	2.2	0.2	-2.4
Vertical activity count, locomotor time 1	0.2	1.4	4.5	-0.7	-0.7	-0.9	-0.6	1.5	1.5	-0.1	-2.1
Time >=10cm from walls, locomotor time 2	0.4	1.1	2.2	0.4	0.7	-1.4	-1.1	0.1	1.5	-1.1	-1.3
Bouts of movement, locomotor time 2	1.0	3.4	7.7	2.6	2.3	-1.0	-1.3	-2.8	-0.9	-1.6	1.3
Total resting periods, locomotor time 2	1.0	4.0	8.6	2.8	2.5	-1.1	-1.5	-2.9	-0.8	-1.8	1.2
Rest time, locomotor task time 2	1.1	1.8	4.0	2.0	1.7	-0.8	-1.1	-2.0	-0.6	-1.1	0.8
Distance moved, locomotor task time 2	1.2	1.6	4.2	-1.5	-1.4	0.1	0.3	2.1	1.2	0.7	-1.7
Vertical activity count, locomotor time 2	0.1	0.3	0.8	-0.5	-0.5	-0.2	-0.1	0.9	0.6	0.1	-0.9
Light reinforcement 1	0.1	0.3	1.0	0.5	0.5	0.2	-0.0	-0.7	-1.0	-0.1	0.7
Light reinforcement 2	1.1	2.5	5.0	1.8	1.9	-0.5	-0.7	-2.2	-1.9	-1.2	1.5
Bone: marrow area	2.0	5.0	7.9	-2.6	-2.8	2.6	2.5	2.0	-0.8	2.7	0.7
Bone: maximum diameter	2.5	5.0	9.3	-2.9	-3.1	2.1	2.1	2.6	0.0	2.5	-0.0
Bone: maximum force	0.1	0.3	0.7	-0.6	-0.8	0.5	0.5	0.6	0.0	0.6	-0.0
Bone: maximum moment	0.3	0.5	1.1	-0.8	-1.1	0.6	0.6	0.8	0.1	0.7	-0.1
Mean time between licks in bursts	0.1	0.4	0.8	-0.7	-0.6	-0.1	0.3	0.9	0.8	0.1	-0.8
Mean num. licks in bursts	0.7	1.8	3.9	-1.8	-1.8	0.6	0.7	2.0	1.0	1.2	-1.0
Cd content in liver	0.9	1.0	1.6	1.3	1.2	-1.1	-0.9	-0.9	0.2	-1.2	-0.2
Co content in liver	1.3	1.5	3.7	-0.8	-0.6	-1.1	-0.6	1.4	1.9	-0.4	-1.9
Cu content in liver	3.5	4.1	7.8	2.8	2.7	-1.5	-2.0	-2.7	-0.6	-1.9	0.6
Fe content in liver	1.4	1.7	3.6	1.7	1.9	-1.0	-1.2	-1.7	-0.3	-1.3	0.3
K content in liver	0.9	0.9	2.0	1.3	1.3	-0.4	-0.7	-1.4	-0.7	-0.8	0.7
Mg content in liver	0.8	0.8	2.0	1.2	1.2	-0.3	-0.6	-1.4	-0.8	-0.6	0.7
Mn content in liver	4.4	4.9	11.4	2.8	2.9	-0.2	-0.6	-3.4	-2.2	-1.3	2.1
Na content in liver	1.1	1.3	2.7	1.5	1.6	-0.5	-0.6	-1.7	-0.7	-1.0	0.6
Rb content in liver	0.1	0.1	0.3	0.2	0.2	-0.3	-0.5	-0.1	0.2	-0.2	-0.2
Se content in liver	12.5	14.8	27.9	5.1	5.3	-3.3	-3.6	-4.8	-0.6	-4.1	0.5
Sr content in liver	0.4	0.3	0.6	0.8	0.7	-0.6	-0.6	-0.6	0.1	-0.7	-0.1
Zn content in liver	1.4	1.6	3.1	1.8	1.6	-0.9	-1.3	-1.7	-0.3	-1.2	0.3
Bone: minimum diameter	4.3	8.2	16.2	-3.8	-4.0	2.1	2.6	3.8	0.8	2.8	-0.8
Time in familiar zone, hab. session 1	0.4	0.5	0.9	-0.4	-0.5	0.9	0.8	0.1	-0.7	0.8	0.8
Time in novel zone, hab. session 1	0.2	0.2	0.4	0.7	0.6	-0.5	-0.6	-0.5	0.1	-0.4	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.4	0.6	0.3	0.1	-0.3	-0.6	-0.5	0.1	0.5
Total locomotion distance, hab. session 1	1.3	1.9	3.4	1.9	1.7	-1.3	-1.7	-1.6	-0.0	-1.3	0.1
Locomotion velocity, hab. session 1	2.2	3.2	5.4	2.3	2.1	-1.9	-2.3	-1.8	0.4	-1.8	-0.3
Time in familiar zone, hab. session 2	0.1	0.1	0.2	-0.4	-0.5	0.4	0.4	0.3	-0.2	0.5	0.2
Time in novel zone, hab. session 2	0.3	0.3	0.4	0.6	0.6	-0.7	-0.6	-0.4	0.4	-0.7	-0.3
Total zone transitions, hab. session 2	0.0	0.1	0.1	0.4	0.3	-0.2	-0.2	-0.3	-0.1	-0.2	0.0
Total locomotion distance, hab. session 2	0.4	0.5	0.8	0.9	0.8	-0.9	-0.9	-0.7	0.2	-0.9	-0.2
Locomotion velocity, hab. session 2	0.5	0.7	1.1	1.1	1.0	-0.8	-0.9	-0.9	-0.0	-0.9	-0.1
Novel to familiar place preference ratio	1.3	1.7	4.7	0.3	0.4	1.3	1.0	-1.2	-2.2	0.6	2.0
Novelty place preference	1.4	1.8	4.8	0.3	0.3	1.4	1.0	-1.1	-2.2	0.7	2.1
Time in novel zone, NPP test	1.4	1.7	4.6	0.2	0.2	1.4	1.1	-1.1	-2.1	0.7	2.1
Total zone transitions, NPP test	0.5	0.7	1.4	0.6	0.5	-1.1	-1.2	-0.1	0.9	-0.8	-1.0
Total locomotion distance, NPP test	2.3	3.2	5.5	2.0	1.9	-2.2	-2.3	-1.4	0.9	-2.1	-0.9
Locomotion velocity, NPP test	2.2	3.1	5.5	1.8	1.8	-2.3	-2.3	-1.1	1.1	-2.0	-1.1
Intraocular pressure	0.3	0.6	2.1	0.3	0.1	0.8	0.4	-0.6	-1.4	0.6	1.0
Delta distance traveled before/after self-admin	1.3	1.4	2.2	-1.4	-1.3	1.5	1.4	1.0	-0.1	1.5	0.5
Delta ambulatory time before/after self-admin	1.2	2.0	3.1	-1.8	-1.7	1.7	1.6	1.4	-0.0	1.7	0.3
Parametrial fat weight	0.8	1.9	5.2	0.4	0.2	-1.6	-1.3	0.6	2.3	-1.1	-1.9
Pavlov. Cond. lever latency	0.5	0.6	1.1	-0.5	-0.5	1.1	1.0	0.1	-0.8	0.8	0.9
Pavlov. Cond. magazine entry latency	1.9	2.5	4.4	0.8	0.8	-2.1	-1.9	0.1	2.0	-1.6	-2.0
Pavlov. Cond. change in total contacts	0.8	0.9	2.0	0.2	0.2	-1.2	-0.9	0.4	1.3	-0.9	-1.4
Pavlov. Cond. index score	1.4	1.8	3.3	1.0	1.0	-1.8	-1.7	-0.3	1.4	-1.5	-1.4
Pavlov. Cond. latency score	1.2	1.6	2.9	0.8	0.8	-1.7	-1.6	-0.1	1.4	-1.3	-1.4
Pavlov. Cond. lever contacts	0.8	0.9	1.7	0.7	0.7	-1.3	-1.2	-0.2	0.9	-1.1	-1.0
Pavlov. Cond. magazine entry number	0.8	1.0	2.2	-0.2	-0.1	1.3	1.1	-0.4	-1.5	0.8	1.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.5	0.4	0.6	-0.5	-0.3	-0.4	-0.0	-0.7	-0.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.6	3.0	0.9	0.9	-1.7	-1.6	-0.3	1.3	-1.4	-1.3
Pavlov. Cond. response bias	0.9	1.2	2.1	0.5	0.4	-1.5	-1.3	0.2	1.4	-1.0	-1.4
Pavlov. Cond. lever latency	1.3	1.8	3.4	-0.9	-0.8	1.9	1.7	0.1	-1.6	1.4	1.5
Pavlov. Cond. magazine entry latency	0.7	1.0	1.8	0.7	0.5	-1.3	-1.3	-0.0	1.3	-0.9	-1.1
Pavlov. Cond. change in total contacts	0.3	0.7	1.7	0.3	0.0	-1.1	-1.0	0.4	1.3	-0.6	-1.2
Pavlov. Cond. index score	1.3	2.0	3.7	1.0	0.7	-1.9	-1.8	-0.1	1.8	-1.3	-1.6
Pavlov. Cond. latency score	1.2	1.9	3.4	1.0	0.7	-1.9	-1.8	-0.1	1.7	-1.3	-1.5
Pavlov. Cond. lever contacts	1.2	1.7	3.3	0.8	0.7	-1.8	-1.7	-0.0	1.7	-1.3	-1.5
Pavlov. Cond. magazine entry number	2.4	3.2	5.8	-1.5	-1.2	2.4	2.3	0.4	-2.0	1.8	1.8
Pavlov. Cond. intertrial magazine entries	0.6	1.4	2.8	-1.0	-0.9	1.7	1.5	0.3	-1.3	1.3	1.1
Pavlov. Cond. lever-magazine prob. diff.	1.3	2.0	3.7	1.0	0.8	-1.9	-1.8	-0.1	1.8	-1.3	-1.6
Pavlov. Cond. response bias	1.5	2.1	4.1	0.9	0.7	-2.0	-1.8	-0.0	1.9	-1.4	-1.7
Time in closed arm before self-admin	0.2	0.4	1.5	0.2	0.3	0.4	0.5	-0.6	-1.2	-0.0	1.0
Time in closed arm after self-admin	0.0	0.0	0.1	-0.0	-0.2	-0.0	0.1	-0.1	-0.2	-0.1	0.3
Time in open arm before self-admin	0.2	0.2	0.5	-0.3	-0.2	0.7	0.5	-0.1	-0.4	0.7	0.7
Time in open arm after self-admin	0.3	0.3	1.0	0.1	0.3	0.7	0.5	-0.4	-1.0	0.4	0.8
Bone: periosteal estimation	1.3	3.2	6.5	-2.3	-2.6	1.6	1.6	2.2	0.2	2.0	-0.2
Bone: periosteal perimeter	1.7	3.3	6.5	-2.3	-2.6	1.6	1.6	2.2	0.2	2.0	-0.2
Bone: post-yield work	0.3	0.6	1.3	-0.8	-0.9	0.9	1.2	0.6	-0.2	0.8	0.2
Progressive ratio test 1 active lever presses	0.1	0.1	0.3	0.3	0.3	0.1	-0.1	-0.5	-0.4	0.1	0.4
Progressive ratio test 1 breakpoint	0.1	0.1	0.3	0.4	0.4	0.0	-0.2	-0.6	-0.3	-0.0	0.3
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.5	-0.6	-0.3	0.6	0.7	-0.1	-0.6	0.3	0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.4	0.4	0.3	0.2	-0.7	-0.6	-0.1	0.7
Progressive ratio test 2 breakpoint	0.2	0.2	0.5	0.4	0.4	0.2	0.2	-0.7	-0.6	-0.1	0.7
Progressive ratio test 2 inactive lever presses	0.2	0.6	1.6	0.3	0.3	0.6	0.5	-0.9	-1.2	0.2	1.3
Incentive Sensitization - Responses	0.0	0.1	0.2	0.3	0.3	0.1	0.2	-0.5	-0.4	-0.3	0.5
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	0.4	0.4	-0.1	0.0	-0.5	-0.2	-0.4	0.2
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.2	0.4	-0.1	-0.1	-0.3	-0.2	-0.1	0.3
Progressive ratio	0.1	0.3	0.7	-0.7	-0.7	0.3	0.3	0.8	0.2	0.5	-0.6
Food seeking constrained by brief footshock	0.8	1.0	1.7	0.7	0.6	-1.3	-1.2	-0.1	1.0	-1.1	-1.1
Seeking ratio, punishment vs. effort	0.6	1.2	1.9	1.3	1.1	-1.3	-1.3	-0.9	0.7	-1.4	-0.4
Retroperitoneal fat weight	0.1	0.3	0.8	-0.5	-0.5	-0.1	0.2	0.8	0.9	0.2	-0.6
Reaction time number correct	0.6	2.2	3.5	-1.4	-1.2	1.9	1.8	0.6	-1.5	1.6	1.4
Reaction time mean minus median	0.2	1.2	3.1	-0.8	-0.9	-0.6	-0.5	1.4	1.5	0.2	-1.8
Reaction time mean minus median AUC	0.1	0.8	1.7	-0.8	-1.0	-0.2	-0.3	1.3	1.0	0.4	-1.3
Reaction time num false alarms	0.2	0.3	0.7	-0.3	-0.4	-0.3	-0.2	0.7	0.9	0.1	-0.8
Reaction time num false alarms AUC	0.2	0.5	1.3	-0.4	-0.5	-0.4	-0.3	1.0	1.1	0.1	-1.1
Reaction time trials correct on left	0.6	2.2	3.5	-1.4	-1.2	1.9	1.8	0.6	-1.5	1.6	1.4
Reaction time trials on left	0.6	2.1	3.2	-1.5	-1.2	1.8	1.8	0.6	-1.4	1.6	1.4
Reaction time mean	0.5	1.2	2.5	0.4	0.3	-1.3	-1.3	0.3	1.6	-0.8	-1.5
Reaction time mean AUC	0.5	1.2	2.2	0.6	0.4	-1.4	-1.4	0.2	1.4	-0.9	-1.5
Median of all reaction times	0.5	0.7	1.2	0.7	0.6	-1.1	-1.1	-0.1	1.0	-0.9	-0.9
Reaction time omissions	0.5	0.8	2.1	-0.8	-0.8	-0.5	-0.3	1.2	1.5	0.0	-1.2
Reaction time false alarm rate	0.8	1.0	2.6	0.3	0.1	-1.2	-1.1	0.5	1.6	-0.6	-1.6
Reaction time premature initiation rate	1.3	2.0	5.5	0.1	-0.1	-1.5	-1.3	0.9	2.3	-0.7	-2.3
Reaction time premature initiations	0.3	1.0	2.9	-0.6	-0.6	-0.7	-0.5	1.2	1.7	-0.0	-1.6
Std. dev. reaction times	0.7	2.2	5.8	-0.7	-0.8	-1.2	-0.9	1.6	2.4	-0.3	-2.4
Reaction time trials completed	0.6	2.1	3.2	-1.5	-1.2	1.8	1.8	0.6	-1.4	1.6	1.4
Reaction time trials AUC	0.6	2.0	3.2	-1.3	-1.1	1.8	1.7	0.5	-1.5	1.5	1.5
Run reversals in cocaine runway, females	1.0	1.1	2.1	1.0	1.1	0.1	0.1	-1.4	-1.4	-0.6	1.4
Run reversals in cocaine runway, males	2.1	2.4	4.2	1.6	1.5	-2.0	-1.9	-0.8	1.1	-1.7	-1.3
Latency to leave start box in cocaine runway	2.5	3.5	5.5	-2.3	-2.4	2.1	2.1	1.7	-0.8	2.1	0.6
Latency to leave start box in cocaine runway, F	3.7	4.7	6.8	-2.5	-2.6	2.5	2.5	1.8	-1.1	2.5	0.9
Latency to leave start box in cocaine runway, M	0.4	0.3	0.7	-0.8	-0.8	0.6	0.6	0.6	-0.1	0.6	0.2
Std. dev. time between licks in bursts	0.1	0.3	0.6	0.7	0.7	-0.2	-0.1	-0.8	-0.4	-0.4	0.4
Total sessions with >9 infusions	0.2	0.2	0.5	0.0	0.1	0.4	0.5	-0.4	-0.6	0.2	0.7
Short access day 1 total inactive lever presses	1.6	3.1	6.2	-1.1	-0.8	2.1	2.2	-0.3	-2.5	1.1	2.5
Short access day 10 total inactive lever presses	0.0	0.2	0.5	0.1	0.3	-0.6	-0.4	-0.1	0.3	-0.7	-0.4
Short access day 1 total infusions	0.5	1.0	2.1	1.0	1.1	-0.1	-0.1	-1.5	-1.3	-0.6	1.2
Short access day 10 total infusions	0.3	0.4	0.7	0.9	0.8	-0.7	-0.6	-0.8	0.1	-0.7	-0.1
Short access total infusions	0.1	0.2	0.4	0.3	0.5	0.0	0.2	-0.7	-0.4	-0.2	0.6
Short access day 1 locomotion	1.4	2.3	5.7	-0.3	-0.3	1.8	1.5	-0.7	-2.4	1.3	2.3
Short access day 10 total locomotion	0.1	0.4	0.8	0.4	0.9	-0.4	-0.1	-0.8	-0.8	-0.7	0.4
Short access total locomotion	0.4	0.6	1.8	0.1	0.3	0.6	0.6	-0.7	-1.3	0.3	1.2
One hour access (0.3 mA shock)	0.2	0.2	0.4	-0.7	-0.6	0.4	0.6	0.3	-0.1	0.4	0.4
Compulsive drug intake	0.9	1.3	3.3	-1.8	-1.5	0.6	1.1	1.5	0.6	0.8	-0.4
One hour access (shock baseline)	0.0	0.0	0.1	0.1	0.0	-0.1	-0.2	-0.0	0.3	-0.1	-0.2
Social response proportion	1.6	2.1	3.6	-1.0	-1.0	1.9	1.6	0.2	-1.7	1.5	1.8
Social responses	0.6	0.8	1.4	-1.1	-1.2	1.0	0.9	0.9	-0.4	1.2	0.3
Social time	0.1	0.2	0.4	-0.2	0.0	-0.6	-0.3	0.3	0.4	-0.4	-0.6
Soleus weight	0.6	1.8	2.7	-1.6	-1.5	1.6	1.6	1.1	-0.8	1.4	0.6
Bone: stiffness	0.3	0.5	1.1	-0.7	-1.0	-0.0	0.2	1.0	0.8	0.4	-0.8
Tibialis anterior weight	0.2	0.7	1.2	-1.1	-0.9	1.1	1.1	0.8	-0.4	0.9	0.2
Time to tail flick, vehicle, before self-admin	0.8	1.0	2.3	0.9	0.9	0.3	0.2	-1.4	-1.3	-0.2	1.5
Time to tail flick, vehicle, after self-admin	0.1	0.2	0.3	-0.5	-0.4	0.5	0.5	0.2	-0.4	0.5	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.6	-0.3	-0.1	0.3	0.4	0.1	-0.8	0.3	0.3
Time to tail flick, test, after self-admin	0.5	0.6	1.6	0.2	0.4	0.7	0.5	-0.7	-1.2	0.2	1.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.5	-0.3	-0.0	0.1	0.6	0.1	0.2	-0.4
Delta time to tail flick, test, before/after SA	0.2	0.3	0.7	0.6	0.7	0.1	-0.0	-0.9	-0.3	-0.3	0.8
Tibia length	0.1	0.3	0.9	-0.3	-0.3	-0.6	-0.3	0.6	0.8	-0.3	-1.0
Ambulatory time before self-admin	0.1	0.3	0.8	0.0	-0.0	0.6	0.6	-0.3	-0.9	0.3	0.9
Ambulatory time after self-admin	1.0	1.7	3.8	-0.9	-0.8	1.9	1.7	0.2	-1.1	1.4	1.4
Bone: tissue strength	0.3	0.3	0.5	-0.6	-0.7	0.2	0.4	0.7	0.4	0.3	-0.4
Total heroin consumption	0.2	0.2	0.4	0.5	0.5	-0.6	-0.6	-0.3	-0.0	-0.6	-0.3
Bone: trabecular number	0.3	0.6	1.2	-0.8	-0.7	0.9	1.1	0.3	-0.8	0.7	0.7
Bone: trabecular spacing	0.6	0.9	2.1	0.1	0.0	-1.1	-1.1	0.5	1.5	-0.6	-1.4
Bone: trabecular thickness	0.7	0.9	1.7	-1.3	-1.3	0.8	1.0	1.2	0.1	1.0	-0.2
Bone: trabecular tissue density	0.7	1.1	2.1	-1.0	-1.2	1.5	1.2	0.7	-0.7	1.3	0.6
Water consumed over 24 hours	0.2	0.4	0.8	0.8	0.8	-0.1	-0.3	-0.9	-0.6	-0.3	0.6
Number of responses in last shaping day	0.1	0.2	0.4	-0.6	-0.3	0.4	0.6	-0.0	-0.3	0.2	0.5