Hub : Genes

LOC120100025

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc intron excision ratio chr1_243782746_243783501 0.05 0.03 2.2e-08 0.04 0.06 0.07 0.08 1.1e-06 7.0e-09 1.9e-11 4.7e-12
2 PL intron excision ratio chr1_243782746_243783501 0.03 0.03 2.3e-03 0.03 0.02 0.02 0.02 5.2e-04 2.7e-03 1.1e-03 1.9e-03
3 pVTA gene expression LOC120100025 0.12 0.06 5.3e-13 0.18 0.17 0.18 0.18 9.8e-15 1.3e-13 1.9e-14 1.3e-14
4 NAcc gene expression LOC120100025 0.32 0.11 0.0e+00 0.31 0.3 0.3 0.31 1.7e-48 6.4e-47 8.8e-46 8.8e-48
5 PL gene expression LOC120100025 0.44 0.12 0.0e+00 0.33 0.32 0.32 0.33 6.7e-37 2.7e-35 2.9e-36 1.2e-36
6 IC gene expression LOC120100025 0.32 0.13 5.9e-11 0.26 0.26 0.24 0.25 1.5e-11 3.4e-11 1.7e-10 5.0e-11
7 BLA gene expression LOC120100025 0.35 0.13 0.0e+00 0.28 0.28 0.29 0.31 1.7e-15 2.2e-15 8.0e-16 8.1e-17
8 Brain gene expression LOC120100025 0.23 0.08 0.0e+00 0.28 0.28 0.27 0.29 1.0e-25 2.7e-26 1.6e-25 1.5e-27
9 IL gene expression LOC120100025 0.24 0.12 8.5e-06 0.25 0.18 0.21 0.21 1.0e-06 5.0e-05 1.1e-05 7.7e-06
10 Adipose gene expression LOC120100025 0.15 0.07 0.0e+00 0.14 0.15 0.16 0.04 7.8e-16 8.3e-17 2.0e-17 9.0e-05
11 OFC gene expression LOC120100025 0.5 0.18 2.6e-09 0.26 0.37 0.36 0.37 6.3e-07 1.3e-09 2.5e-09 1.3e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density9.616.519.43.74.24.24.24.24.34.44.24.03.63.2
Area under the delay curve0.20.20.5-0.1-0.5-0.6-0.5-0.5-0.6-0.4-0.3-0.2-0.7-0.7
BMI with tail0.20.82.10.51.40.90.90.90.70.70.90.61.40.4
BMI without tail0.10.21.20.50.3-0.2-0.3-0.3-0.0-0.10.10.00.5-1.1
Body weight0.94.08.02.82.81.81.91.91.91.52.01.41.9-1.4
Weight adjusted by age0.40.71.60.40.60.70.50.50.81.00.91.10.91.3
Bone surface4.98.810.32.63.13.03.03.03.13.23.02.93.12.4
Bone volume6.812.314.53.43.83.63.53.53.83.83.73.63.42.2
Breakpoint value in progressive ratio session0.20.30.50.70.50.50.50.50.70.20.40.30.1-0.7
Number of licking bursts1.62.63.6-1.5-1.5-1.6-1.9-1.9-1.6-1.7-1.5-1.6-1.5-1.2
Context. condit. distance diff. score2.22.74.52.11.81.61.61.61.71.61.81.81.3-0.3
Locomotion velocity, session 12.22.36.4-2.5-1.1-1.7-1.7-1.7-1.6-1.4-1.5-1.4-0.50.6
Locomotion distance, session 10.10.20.7-0.8-0.5-0.4-0.4-0.4-0.5-0.4-0.4-0.3-0.10.2
Locomotion velocity, session 20.80.91.3-1.1-0.9-1.0-1.1-1.1-1.1-1.1-0.9-0.8-0.2-0.2
Locomotion distance, session 20.50.71.3-0.4-1.0-0.7-0.8-0.8-0.8-0.9-0.9-0.9-0.8-1.2
Locomotion velocity, session 30.10.10.30.50.30.20.10.10.20.30.40.50.4-0.5
Locomotion distance, session 30.40.41.41.10.50.30.30.30.30.30.60.60.4-1.2
Stereotopy head waving bouts, day 30.10.21.2-0.60.0-0.1-0.0-0.0-0.00.10.00.30.31.1
Stereotopy head waving duration, day 30.10.21.2-0.60.20.00.10.10.10.20.10.40.01.1
Locomotion velocity, session 70.70.82.21.50.80.90.80.80.90.70.91.00.4-0.7
Locomotion distance, session 70.60.82.01.40.91.00.90.91.00.90.90.80.2-0.4
Stereotopy head waving bouts, day 70.20.30.7-0.8-0.5-0.7-0.5-0.5-0.6-0.5-0.4-0.3-0.10.2
Stereotopy head waving duration, day 70.10.10.5-0.70.0-0.4-0.2-0.2-0.3-0.2-0.1-0.10.50.6
Locomotion velocity, session 80.20.30.50.40.60.70.40.40.50.50.60.70.40.4
Locomotion distance, session 80.40.61.91.40.60.80.60.60.80.70.70.80.3-0.8
Degree of sensitization distance0.10.10.60.00.10.20.10.10.20.1-0.1-0.2-0.70.0
Degree of sensitization stereotypy0.00.00.1-0.4-0.2-0.3-0.2-0.2-0.2-0.1-0.0-0.00.10.2
Conditioned locomotion0.80.91.80.81.01.00.90.91.11.11.21.30.70.4
Cocaine response after cond. corrected0.10.10.50.10.10.0-0.1-0.10.10.20.30.30.70.5
Cocaine response after cond. not corrected0.10.10.40.70.20.10.00.00.10.10.30.30.5-0.3
Cocaine response before conditioning0.60.73.10.3-0.5-0.5-0.5-0.5-0.6-0.8-0.7-0.9-1.0-1.7
Saline control response0.10.20.91.00.10.30.20.20.30.30.50.70.2-0.2
Bone: connectivity density5.28.19.32.32.93.13.13.12.93.02.82.52.63.0
Bone: cortical apparent density1.11.52.6-1.6-1.5-1.3-1.3-1.3-1.2-1.2-1.0-0.7-1.50.1
Bone: cortical area3.14.77.42.72.72.12.12.12.22.02.32.02.3-0.4
Bone: cortical porosity0.00.00.10.1-0.2-0.0-0.1-0.1-0.1-0.0-0.2-0.10.3-0.1
Bone: cortical porosity0.10.10.30.50.10.20.10.10.10.1-0.0-0.00.5-0.2
Bone: cortical thickness0.30.51.61.01.00.50.50.50.50.30.80.60.7-1.3
Bone: cortical thickness0.20.20.6-0.4-0.5-0.5-0.5-0.5-0.3-0.3-0.00.2-0.2-0.8
Bone: cortical tissue density1.21.62.9-1.7-1.5-1.3-1.3-1.3-1.2-1.2-1.1-0.8-1.60.2
Condit. Reinf. active minus inactive responses1.01.11.7-0.9-0.9-1.2-1.2-1.2-1.2-1.1-0.9-0.8-0.9-1.3
Condit. Reinf. active-inactive response ratio1.31.42.5-1.6-1.0-1.4-1.3-1.3-1.3-1.2-1.2-1.2-0.7-0.2
Condit. Reinf. active responses0.10.21.40.40.1-0.3-0.2-0.2-0.2-0.10.20.4-0.0-1.2
Condit. Reinf. inactive responses1.21.53.01.71.11.11.11.11.21.11.41.70.8-0.4
Incentive salience index mean1.41.74.1-0.7-0.9-1.4-1.4-1.4-1.4-1.4-1.1-1.1-1.2-2.0
Condit. Reinf. lever presses1.92.65.0-0.9-1.3-1.6-1.6-1.6-1.6-1.7-1.5-1.7-1.8-2.2
Condit. Reinf. active minus inactive responses0.30.41.11.00.40.40.40.40.50.50.60.90.7-1.0
Condit. Reinf. active-inactive response ratio0.10.10.40.3-0.1-0.0-0.0-0.00.20.20.20.40.3-0.6
Condit. Reinf. active responses1.31.73.21.81.21.11.21.21.21.31.51.71.5-0.4
Condit. Reinf. inactive responses0.91.22.01.41.30.91.11.10.91.01.21.21.20.2
Condit. Reinf. lever presses0.20.21.30.10.20.1-0.1-0.10.30.40.40.71.10.3
Condit. Reinf. lever reinforcers received0.81.12.01.40.90.80.80.81.01.01.11.41.3-0.4
Conditioned reinforcement - actives0.91.52.91.61.41.41.71.71.21.11.00.60.60.6
Conditioned reinforcement - inactives1.21.72.91.51.41.41.71.71.31.41.20.90.71.0
Conditioned locomotion1.11.42.21.01.11.31.51.51.11.11.00.61.41.3
Patch foraging indifference point 0 sec0.10.30.7-0.0-0.2-0.3-0.3-0.3-0.2-0.5-0.5-0.7-0.8-0.8
Patch foraging indifference point AUC1.42.04.0-1.4-1.2-1.4-1.1-1.1-1.6-1.6-1.2-1.1-2.0-1.3
Delay disc. indifference point, 0s delay0.40.41.41.20.50.30.40.40.30.50.70.7-0.2-0.9
Delay disc. indifference point, 16s delay0.10.10.30.30.30.30.20.20.20.50.40.60.10.3
Delay disc. indifference point, 2s delay0.10.10.2-0.0-0.4-0.0-0.1-0.10.10.20.20.5-0.10.5
Delay disc. indifference point, 24s delay1.61.83.0-1.1-1.0-1.6-1.2-1.2-1.3-1.3-1.3-1.4-1.6-1.7
Delay disc. indifference point, 4s delay0.10.10.90.5-0.3-0.1-0.0-0.0-0.2-0.00.10.1-0.5-0.9
Delay disc. indifference point, 8s delay1.61.92.6-1.4-1.5-1.6-1.6-1.6-1.5-1.4-1.4-1.1-1.3-0.7
Indifference point function ln k1.32.33.91.91.41.51.31.31.91.71.31.32.00.6
Indifference point function log k1.32.33.91.91.41.51.31.31.91.71.31.32.00.6
Patch foraging total patch changes 0 sec0.10.20.60.0-0.2-0.2-0.2-0.2-0.2-0.4-0.4-0.7-0.8-0.7
Patch foraging total patch changes 12 sec1.62.13.2-1.6-1.4-1.5-1.3-1.3-1.7-1.7-1.4-1.5-1.8-0.7
Patch foraging total patch changes 18 sec0.30.51.9-0.6-0.7-0.7-0.5-0.5-0.6-0.7-0.4-0.3-1.4-0.6
Patch foraging total patch changes 24 sec0.50.92.7-0.2-1.0-0.8-0.9-0.9-0.5-0.7-0.7-0.6-1.7-1.5
Patch foraging total patch changes 6 sec1.72.64.6-1.8-1.3-1.6-1.5-1.5-1.7-1.8-1.6-1.7-2.1-1.1
Patch foraging time to switch 0 sec0.40.81.4-1.2-1.1-1.1-1.1-1.1-1.0-0.8-1.0-0.8-0.20.2
Patch foraging water rate 0 sec0.20.40.70.80.70.70.80.80.70.60.60.40.0-0.3
Patch foraging water rate 12 sec0.20.41.00.91.00.80.50.50.80.40.50.10.8-0.4
Patch foraging water rate 18 sec0.60.92.81.70.91.10.80.81.20.90.60.21.0-0.4
Patch foraging water rate 24 sec1.11.53.71.91.61.31.11.11.21.01.20.81.1-0.6
Patch foraging water rate 6 sec0.10.10.3-0.00.10.50.10.10.40.40.40.40.10.5
Seeking ratio, delayed vs. immediate footshock0.10.10.8-0.3-0.0-0.20.10.1-0.3-0.4-0.1-0.0-0.9-0.4
Distance traveled before self-admin0.20.30.7-0.3-0.8-0.6-0.7-0.7-0.5-0.6-0.5-0.3-0.0-0.6
Distance traveled after self-admin1.01.25.10.30.60.90.70.70.81.21.01.21.42.2
Extensor digitorum longus weight0.31.23.61.91.21.10.70.71.20.91.00.9-0.4-1.5
Bone: elastic displacement1.71.94.0-2.0-1.8-1.2-1.5-1.5-1.2-1.1-1.5-1.2-0.81.0
Bone: elastic work0.60.72.1-1.1-1.2-0.5-0.8-0.8-0.5-0.4-1.0-0.8-0.21.4
Bone: endosteal estimation5.011.013.83.73.33.43.43.43.63.63.23.13.42.0
Bone: endosteal perimeter5.511.613.43.63.53.63.73.73.73.63.32.93.52.2
Epididymis fat weight1.24.15.12.12.32.01.91.92.02.02.22.12.31.0
Delta time in closed arm before/after self-admin1.51.42.2-1.3-0.7-1.3-0.9-0.9-1.3-1.5-1.1-1.4-0.8-1.2
Delta time in open arm before/after self-admin0.20.20.70.30.00.20.10.10.20.70.40.90.40.9
Diff in mean of infusions in LGA sessions0.30.41.00.60.60.70.70.71.00.50.50.50.1-0.2
Delay discount exponential model param0.30.30.60.20.60.70.60.60.70.40.40.30.70.8
Extinction: sum of active levers before priming0.20.21.10.40.8-0.20.20.2-0.0-0.20.1-0.10.1-1.1
Active lever presses in extinction session 61.51.53.31.80.91.21.31.31.41.31.21.31.00.1
Bone: final force1.22.03.31.81.61.41.41.41.51.41.41.11.5-0.4
Bone: final moment1.11.82.61.61.51.41.41.41.51.41.31.11.50.1
Food consumed during 24 hour testing period0.20.30.7-0.2-0.5-0.5-0.6-0.6-0.6-0.6-0.6-0.8-0.4-0.6
Glucose0.00.00.2-0.40.2-0.20.10.1-0.1-0.10.10.10.2-0.3
Heart weight0.10.21.1-1.00.3-0.3-0.4-0.4-0.2-0.1-0.3-0.5-0.30.7
Delay discount hyperbolic model param0.30.30.50.30.60.60.60.60.70.40.40.30.70.6
Intermittent access intake day 1-15 change0.91.92.81.61.71.61.71.71.31.11.00.51.50.6
Intermittent access intake escalation1.02.13.31.81.71.71.71.71.41.21.20.71.50.5
Intermittent access intake escalation 20.50.51.00.80.91.01.01.00.70.50.50.10.50.0
Intermitt. access day 1 inactive lever presses0.10.31.2-0.4-1.1-0.4-0.8-0.8-0.2-0.1-0.4-0.1-0.50.3
Intermitt. access day 15 inactive lever presses1.22.54.51.21.61.51.71.71.41.81.51.51.12.1
Intermitt. access escalation Index0.60.91.4-0.9-0.6-0.9-0.9-0.9-0.9-1.2-0.9-1.1-0.9-1.0
Intermittent access day 1 total infusions1.42.33.71.91.31.81.81.81.61.61.41.21.00.8
Intermittent access day 15 total infusions3.65.48.62.92.72.72.82.82.22.12.11.52.00.9
Intermittent access terminal intake (last 3 days)2.93.85.82.32.22.32.42.41.91.81.71.31.51.1
Intermittent access total infusions3.03.65.52.32.12.22.32.31.81.81.71.41.30.9
Intermittent access day 1 locomotion1.51.93.82.01.11.71.51.51.51.51.31.11.20.4
Intermittent access day 15 total locomotion2.34.25.22.11.92.22.32.32.02.11.91.62.31.6
Intermittent access total locomotion3.33.95.52.41.92.32.32.32.02.01.91.51.81.2
Intermittent access standard deviation0.81.72.91.41.71.31.41.41.21.11.20.81.50.6
Left kidney weight0.31.64.01.82.01.01.11.10.90.71.20.61.3-1.2
Right kidney weight0.10.63.80.91.30.10.30.3-0.1-0.20.3-0.2-0.1-1.9
Cocaine induced anxiety0.40.61.11.00.80.70.80.80.80.80.60.50.90.3
Post-drug Anxiety1.01.02.10.61.10.70.90.90.91.00.90.91.41.4
Baseline Anxiety0.50.52.30.00.50.50.50.50.40.70.70.81.01.5
Tail length0.31.24.92.20.70.40.40.40.80.70.90.9-0.3-2.0
Length with tail1.04.310.73.32.51.91.91.92.01.72.21.91.4-1.6
Length without tail2.68.313.33.43.73.13.03.03.02.73.12.52.60.1
Times rat made contact with spout0.20.20.80.9-0.10.20.00.00.40.50.20.4-0.3-0.6
Lifetime Intake2.93.55.72.42.02.22.32.31.71.81.71.31.31.0
Liver weight, left0.60.91.51.01.20.71.01.01.01.01.21.10.9-0.1
Liver weight, right1.42.54.61.52.21.81.61.62.01.61.61.50.70.5
Locomotor activity0.30.50.9-0.8-1.0-0.7-0.8-0.8-0.8-0.5-0.7-0.5-0.6-0.1
Locomotor testing distance0.71.31.9-1.1-1.2-1.1-1.2-1.2-1.4-1.2-1.2-1.2-0.8-0.2
Locomotor testing rearing0.10.10.50.70.20.40.20.20.10.00.20.10.4-0.5
Locomotion in novel chamber1.92.45.01.61.01.61.31.31.71.61.51.92.21.2
Locomotion in novel chamber post-restriction1.32.25.32.31.41.61.11.11.51.31.61.81.2-0.3
Fecal boli incidents, locomotor time 10.10.20.50.70.60.30.40.40.10.00.1-0.3-0.7-0.4
Change in fecal boli incidents, locomotor task0.60.61.0-0.4-0.9-0.6-1.0-1.0-0.6-0.6-0.9-0.7-0.8-0.7
Time >=10cm from walls, locomotor time 11.61.74.02.01.61.11.01.01.21.11.41.41.3-0.6
Bouts of movement, locomotor time 10.40.51.51.20.60.80.90.90.70.30.3-0.00.3-0.4
Total resting periods, locomotor time 10.60.72.11.50.71.01.01.00.90.50.40.10.1-0.5
Rest time, locomotor task time 10.20.21.3-0.1-0.10.00.20.2-0.0-0.2-0.4-0.6-1.20.3
Distance moved, locomotor task time 10.40.72.1-0.3-1.0-0.8-1.1-1.1-0.6-0.6-0.40.0-0.4-1.5
Vertical activity count, locomotor time 10.00.00.2-0.0-0.0-0.0-0.1-0.10.00.00.20.40.5-0.2
Time >=10cm from walls, locomotor time 20.20.21.30.70.0-0.1-0.3-0.3-0.2-0.20.0-0.0-0.7-1.1
Bouts of movement, locomotor time 21.01.63.2-0.9-1.3-1.0-0.9-0.9-0.9-1.3-1.5-1.8-1.8-1.1
Total resting periods, locomotor time 21.01.73.6-0.8-1.3-1.0-0.9-0.9-0.9-1.3-1.6-1.9-1.9-1.3
Rest time, locomotor task time 20.10.20.70.50.10.10.20.20.1-0.2-0.3-0.5-0.8-0.8
Distance moved, locomotor task time 20.20.20.80.0-0.6-0.5-0.6-0.6-0.4-0.30.00.4-0.1-0.9
Vertical activity count, locomotor time 20.40.61.0-0.9-1.0-0.9-0.6-0.6-0.9-0.8-0.7-0.7-0.4-0.2
Light reinforcement 10.40.91.60.80.61.00.90.91.21.30.80.80.31.3
Light reinforcement 21.11.63.8-2.0-1.5-1.2-1.2-1.2-1.0-0.8-1.3-1.2-1.21.0
Bone: marrow area5.411.814.63.83.43.53.63.63.83.73.33.23.52.2
Bone: maximum diameter9.818.221.84.44.74.34.34.34.64.54.44.24.52.1
Bone: maximum force2.54.45.32.32.32.22.22.22.32.22.21.92.20.5
Bone: maximum moment2.34.04.82.02.22.12.12.12.22.22.01.82.10.9
Mean time between licks in bursts0.92.34.7-2.2-1.4-1.6-1.9-1.9-1.5-1.4-1.4-1.3-1.00.1
Mean num. licks in bursts1.62.53.61.91.31.61.81.81.71.81.51.61.10.7
Cd content in liver2.02.24.4-2.1-1.2-1.5-1.4-1.4-1.7-1.6-1.6-1.9-0.6-0.4
Co content in liver0.80.93.0-1.7-0.9-0.9-0.9-0.9-1.0-0.8-0.9-0.8-0.30.8
Cu content in liver1.31.64.2-2.0-1.5-1.0-1.2-1.2-1.0-0.8-1.1-0.8-0.71.7
Fe content in liver1.72.02.7-1.4-1.7-1.4-1.6-1.6-1.3-1.3-1.5-1.3-1.6-0.7
K content in liver0.40.41.4-0.2-0.8-0.4-0.5-0.5-0.4-0.5-0.7-0.5-1.2-0.4
Mg content in liver0.50.51.1-0.9-1.0-0.7-0.8-0.8-0.6-0.6-0.7-0.4-1.0-0.0
Mn content in liver1.01.12.4-1.6-1.1-1.1-0.9-0.9-1.1-1.0-1.1-1.1-1.1-0.1
Na content in liver1.41.62.1-0.8-1.4-1.3-1.5-1.5-1.2-1.3-1.2-1.0-1.2-1.1
Rb content in liver0.20.20.60.60.10.4-0.1-0.10.50.60.40.8-0.20.2
Se content in liver24.829.341.4-6.4-5.8-5.7-5.6-5.6-5.7-5.6-5.7-5.5-4.7-2.0
Sr content in liver0.50.52.9-1.3-0.2-0.2-0.2-0.2-0.20.0-0.10.00.71.7
Zn content in liver7.58.310.0-2.9-3.2-2.9-3.0-3.0-3.1-3.0-3.0-2.9-2.9-1.7
Bone: minimum diameter5.710.415.84.03.73.33.33.33.33.23.32.83.40.7
Time in familiar zone, hab. session 10.10.10.50.10.20.30.10.10.30.30.20.30.70.6
Time in novel zone, hab. session 10.70.72.4-0.9-1.0-0.7-0.7-0.7-0.8-0.8-0.7-0.7-1.6-0.5
Total zone transitions, hab. session 10.10.10.4-0.10.00.30.30.30.40.50.50.60.10.5
Total locomotion distance, hab. session 10.30.41.3-0.8-1.1-0.7-0.7-0.7-0.5-0.4-0.5-0.1-0.9-0.3
Locomotion velocity, hab. session 10.50.71.8-0.8-1.3-0.9-0.9-0.9-0.7-0.6-0.7-0.4-1.0-0.7
Time in familiar zone, hab. session 20.30.30.7-0.8-0.4-0.5-0.6-0.6-0.5-0.5-0.7-0.7-0.10.3
Time in novel zone, hab. session 20.10.10.2-0.10.30.20.30.30.10.20.30.4-0.10.2
Total zone transitions, hab. session 20.40.61.5-1.2-0.7-0.8-0.9-0.9-0.8-0.8-0.6-0.5-0.2-0.3
Total locomotion distance, hab. session 20.60.81.3-1.2-0.9-1.0-0.9-0.9-1.0-1.0-0.8-0.8-0.2-0.5
Locomotion velocity, hab. session 20.50.71.0-0.9-1.0-0.9-0.8-0.8-1.0-1.0-0.8-0.8-0.3-0.8
Novel to familiar place preference ratio1.11.22.21.20.81.31.51.51.21.11.10.9-0.30.8
Novelty place preference1.31.42.41.20.81.41.61.61.31.21.21.0-0.31.0
Time in novel zone, NPP test0.91.01.80.90.61.11.31.31.11.01.00.8-0.50.9
Total zone transitions, NPP test0.60.91.2-0.8-1.0-1.0-1.1-1.1-1.0-1.0-0.9-0.7-0.5-1.0
Total locomotion distance, NPP test1.21.62.9-1.2-1.7-1.4-1.4-1.4-1.3-1.2-1.2-0.9-1.2-0.9
Locomotion velocity, NPP test1.01.42.5-0.8-1.6-1.4-1.3-1.3-1.2-1.2-1.1-0.9-1.1-1.1
Intraocular pressure0.40.61.30.70.20.70.70.70.81.10.81.1-0.00.6
Delta distance traveled before/after self-admin3.53.75.01.52.12.02.02.01.92.12.01.81.62.2
Delta ambulatory time before/after self-admin3.54.35.51.72.22.22.12.12.02.32.12.01.52.3
Parametrial fat weight0.92.19.8-0.1-0.9-1.2-1.3-1.3-1.1-1.5-1.3-1.4-0.6-3.1
Pavlov. Cond. lever latency0.70.94.5-0.30.50.60.60.60.80.90.71.01.22.1
Pavlov. Cond. magazine entry latency1.62.04.4-1.1-0.7-1.5-1.3-1.3-1.5-1.6-1.4-1.7-0.8-2.1
Pavlov. Cond. change in total contacts2.62.73.7-1.4-1.2-1.8-1.7-1.7-1.8-1.9-1.6-1.8-1.2-1.9
Pavlov. Cond. index score1.31.66.6-0.2-0.5-1.1-1.0-1.0-1.2-1.3-1.1-1.4-1.0-2.6
Pavlov. Cond. latency score1.11.47.40.1-0.5-1.0-0.8-0.8-1.1-1.2-0.9-1.2-1.1-2.7
Pavlov. Cond. lever contacts1.31.55.0-0.2-0.9-1.0-1.0-1.0-1.2-1.3-1.1-1.4-1.4-2.2
Pavlov. Cond. magazine entry number0.91.22.30.90.31.11.01.01.21.31.11.50.51.4
Pavlov. Cond. intertrial magazine entries0.50.61.71.30.50.70.70.70.80.80.91.10.4-0.1
Pavlov. Cond. lever-magazine prob. diff.1.72.16.6-0.5-0.8-1.4-1.3-1.3-1.5-1.6-1.4-1.7-1.3-2.6
Pavlov. Cond. response bias1.82.23.9-1.2-1.0-1.6-1.5-1.5-1.6-1.7-1.6-2.0-1.0-1.6
Pavlov. Cond. lever latency0.20.20.70.70.10.40.40.40.30.1-0.1-0.4-0.8-0.7
Pavlov. Cond. magazine entry latency1.21.52.2-1.5-1.0-1.4-1.5-1.5-1.4-1.4-1.0-0.8-0.6-0.9
Pavlov. Cond. change in total contacts0.10.20.5-0.1-0.3-0.6-0.7-0.7-0.5-0.4-0.20.10.1-0.6
Pavlov. Cond. index score0.10.20.4-0.5-0.2-0.6-0.6-0.6-0.5-0.4-0.10.20.4-0.4
Pavlov. Cond. latency score0.10.10.4-0.2-0.0-0.4-0.4-0.4-0.3-0.20.10.40.6-0.3
Pavlov. Cond. lever contacts0.10.20.6-0.7-0.0-0.4-0.4-0.4-0.3-0.20.10.40.80.5
Pavlov. Cond. magazine entry number1.62.03.01.41.31.61.71.71.61.51.31.00.71.4
Pavlov. Cond. intertrial magazine entries0.91.43.11.81.01.21.31.31.31.21.11.10.5-0.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.6-0.6-0.3-0.7-0.7-0.7-0.6-0.5-0.20.10.2-0.5
Pavlov. Cond. response bias0.60.81.6-1.2-0.7-1.1-1.2-1.2-1.1-1.0-0.7-0.4-0.1-0.2
Time in closed arm before self-admin0.10.20.7-0.1-0.70.1-0.6-0.6-0.0-0.2-0.3-0.2-0.80.1
Time in closed arm after self-admin1.92.12.9-1.3-1.7-1.4-1.6-1.6-1.4-1.5-1.3-1.2-1.4-1.1
Time in open arm before self-admin0.10.10.3-0.6-0.1-0.10.10.1-0.1-0.1-0.1-0.20.30.3
Time in open arm after self-admin1.31.53.00.60.91.11.11.11.11.31.11.21.71.7
Bone: periosteal estimation6.213.016.94.13.93.73.73.73.93.83.63.43.81.5
Bone: periosteal perimeter5.28.912.53.53.33.13.13.13.23.03.02.63.20.8
Bone: post-yield work1.62.33.81.82.01.41.71.71.61.51.71.31.0-0.4
Progressive ratio test 1 active lever presses3.03.74.71.81.92.02.22.21.72.11.81.81.71.9
Progressive ratio test 1 breakpoint2.63.24.01.71.81.82.02.01.62.01.71.71.51.8
Progressive ratio test 1 inactive lever presses1.42.03.51.51.51.81.91.91.61.31.20.80.10.9
Progressive ratio test 2 active lever presses6.47.510.43.02.83.13.23.22.72.72.72.42.21.9
Progressive ratio test 2 breakpoint7.08.010.93.12.93.23.33.32.82.82.72.42.22.0
Progressive ratio test 2 inactive lever presses2.03.35.01.81.82.22.22.21.71.81.61.31.01.9
Incentive Sensitization - Responses3.54.98.02.82.32.82.72.72.52.02.01.51.40.8
Incentive Sensitization - Breakpoint4.15.48.42.92.42.82.82.82.52.12.11.61.50.9
Sum of active levers in priming session hrs 5-60.70.61.1-1.1-0.9-0.8-0.9-0.9-0.6-0.6-0.9-0.7-0.50.5
Progressive ratio0.20.32.00.40.1-0.2-0.2-0.2-0.5-0.7-0.2-0.30.1-1.4
Food seeking constrained by brief footshock1.21.43.21.81.61.01.21.20.90.91.00.51.6-0.6
Seeking ratio, punishment vs. effort0.00.00.20.1-0.1-0.1-0.0-0.00.10.40.00.0-0.00.3
Retroperitoneal fat weight0.10.31.20.70.60.30.30.30.60.50.40.31.1-0.3
Reaction time number correct1.42.74.21.81.51.71.41.41.82.01.71.71.51.1
Reaction time mean minus median0.10.20.7-0.40.70.00.60.6-0.0-0.30.1-0.30.70.8
Reaction time mean minus median AUC0.10.20.9-0.80.1-0.30.10.1-0.3-0.5-0.2-0.40.21.0
Reaction time num false alarms0.60.93.01.70.60.90.70.71.00.90.90.90.3-1.0
Reaction time num false alarms AUC0.30.41.91.40.20.50.30.30.60.50.50.50.0-1.2
Reaction time trials correct on left1.42.74.21.81.51.71.41.41.82.01.71.71.51.1
Reaction time trials on left1.42.64.01.81.51.71.41.41.82.01.71.71.51.1
Reaction time mean2.23.47.2-2.7-1.7-2.1-1.6-1.6-2.1-2.2-1.9-1.9-1.3-0.3
Reaction time mean AUC2.74.38.6-2.9-1.9-2.3-1.8-1.8-2.3-2.4-2.1-2.3-1.6-0.2
Median of all reaction times3.24.69.0-3.0-2.2-2.4-2.0-2.0-2.3-2.3-2.2-2.1-1.7-0.3
Reaction time omissions0.20.30.8-0.9-0.3-0.7-0.5-0.5-0.8-0.7-0.10.10.6-0.4
Reaction time false alarm rate0.20.32.00.7-0.3-0.1-0.2-0.2-0.0-0.3-0.1-0.1-0.5-1.4
Reaction time premature initiation rate1.01.42.31.51.51.11.51.51.10.81.10.71.5-0.1
Reaction time premature initiations2.74.77.02.72.52.12.42.42.22.02.21.82.40.6
Std. dev. reaction times0.40.82.5-1.6-0.4-1.1-0.5-0.5-1.2-1.3-0.8-0.9-0.20.2
Reaction time trials completed1.42.64.01.81.51.71.41.41.82.01.71.71.51.1
Reaction time trials AUC1.02.03.21.61.31.51.21.21.61.81.51.51.30.9
Run reversals in cocaine runway, females0.10.10.7-0.3-0.00.30.00.00.10.1-0.10.00.80.9
Run reversals in cocaine runway, males0.40.40.8-0.3-0.4-0.8-0.5-0.5-0.6-0.7-0.6-0.80.1-0.9
Latency to leave start box in cocaine runway0.70.83.00.70.30.90.80.80.81.01.21.70.1-0.1
Latency to leave start box in cocaine runway, F0.30.30.80.6-0.20.50.30.30.50.40.50.9-0.9-0.7
Latency to leave start box in cocaine runway, M1.21.12.60.50.80.81.11.10.71.11.41.61.30.7
Std. dev. time between licks in bursts2.43.25.6-2.4-1.7-1.9-2.0-2.0-1.9-1.8-1.9-1.9-1.1-0.3
Total sessions with >9 infusions0.10.10.20.40.50.40.50.5-0.10.0-0.1-0.4-0.4-0.1
Short access day 1 total inactive lever presses1.31.72.80.91.11.41.51.51.41.41.21.10.71.7
Short access day 10 total inactive lever presses0.20.51.6-0.3-0.8-0.6-0.6-0.6-0.5-0.7-0.6-0.5-1.3-0.8
Short access day 1 total infusions0.00.00.20.10.10.20.20.2-0.2-0.1-0.3-0.4-0.20.1
Short access day 10 total infusions0.10.10.40.3-0.00.30.20.2-0.10.0-0.4-0.7-0.60.2
Short access total infusions0.91.12.01.41.21.41.41.40.81.00.70.40.50.7
Short access day 1 locomotion0.10.10.3-0.3-0.2-0.10.10.1-0.5-0.5-0.4-0.5-0.4-0.5
Short access day 10 total locomotion0.00.10.20.2-0.5-0.1-0.3-0.30.1-0.1-0.3-0.30.0-0.3
Short access total locomotion0.20.20.5-0.4-0.6-0.2-0.4-0.4-0.5-0.4-0.6-0.7-0.3-0.2
One hour access (0.3 mA shock)7.58.612.23.03.43.33.53.53.02.72.92.32.31.8
Compulsive drug intake0.10.20.40.10.60.40.40.40.40.30.60.6-0.2-0.4
One hour access (shock baseline)2.74.16.02.32.32.22.52.51.91.81.81.32.01.4
Social response proportion0.70.82.9-0.10.60.70.80.80.80.90.60.51.11.7
Social responses1.01.32.30.61.21.31.41.41.31.20.90.70.71.5
Social time0.91.22.0-1.3-0.9-1.0-0.9-0.9-1.0-1.2-1.2-1.4-1.4-0.8
Soleus weight1.03.14.21.22.11.91.71.71.91.81.81.71.51.8
Bone: stiffness2.33.77.02.72.32.02.12.12.11.92.01.61.2-0.7
Tibialis anterior weight0.61.95.42.31.31.51.21.21.51.31.41.4-0.0-1.3
Time to tail flick, vehicle, before self-admin0.20.21.2-0.9-0.4-0.2-0.2-0.2-0.2-0.1-0.3-0.3-0.11.1
Time to tail flick, vehicle, after self-admin0.60.85.71.4-0.00.10.30.30.2-0.4-0.1-0.3-0.2-2.4
Time to tail flick, test, before self-admin1.51.52.71.31.71.21.31.31.11.31.41.40.90.5
Time to tail flick, test, after self-admin0.90.92.2-0.7-1.2-1.0-0.9-0.9-0.9-0.8-0.9-0.8-1.5-0.5
Delta time to tail flick, vehicle, before/after SA1.91.87.32.70.80.91.11.11.00.50.90.80.7-2.4
Delta time to tail flick, test, before/after SA0.91.01.3-0.9-1.1-0.9-0.9-0.9-0.9-1.0-1.1-1.1-1.1-0.7
Tibia length0.10.20.60.60.30.20.20.20.40.40.40.50.8-0.2
Ambulatory time before self-admin0.50.71.1-0.8-1.0-1.0-1.0-1.0-0.9-0.9-0.8-0.6-0.1-0.8
Ambulatory time after self-admin1.31.63.10.71.01.21.01.01.11.41.31.51.41.8
Bone: tissue strength0.40.41.0-1.0-0.3-0.4-0.4-0.4-0.5-0.5-0.7-1.0-0.50.4
Total heroin consumption0.91.11.91.40.91.11.31.31.30.90.90.61.00.1
Bone: trabecular number5.79.511.02.63.33.23.23.23.23.33.12.92.72.9
Bone: trabecular spacing2.73.64.7-1.7-1.8-2.0-2.1-2.1-2.0-2.0-1.8-1.7-1.5-2.2
Bone: trabecular thickness5.46.77.92.62.82.72.72.72.72.72.62.42.51.6
Bone: trabecular tissue density1.92.94.01.91.51.81.71.71.81.71.92.01.50.6
Water consumed over 24 hours0.20.31.60.8-0.4-0.1-0.3-0.30.10.1-0.2-0.1-0.6-1.3
Number of responses in last shaping day0.10.10.7-0.20.30.30.30.30.20.1-0.0-0.10.00.8