Hub : Genes

LOC120099930

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120099930	0.09	0.04	9.3e-07	0.06	0.06	0.05	0.06	1.3e-06	2.6e-06	1.9e-05	3.2e-06
2	Adipose	gene expression	LOC120099930	0.22	0.1	0.0e+00	0.12	0.14	0.13	0.13	4.9e-13	7.9e-15	5.8e-14	1.7e-14
3	Adipose	isoform ratio	XR_010060839.1	0.37	0.14	1.7e-13	0.05	0.11	0.1	0.1	1.5e-06	2.2e-12	5.4e-11	1.7e-11
4	Adipose	isoform ratio	XR_005499451.2	0.36	0.14	6.8e-14	0.05	0.12	0.1	0.11	1.4e-06	1.1e-12	1.3e-11	8.0e-12

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.5	1.0	1.3	-0.4	-1.1	-1.1	1.1
Area under the delay curve	0.0	0.1	0.1	0.1	-0.2	-0.3	0.3
BMI with tail	1.7	5.9	12.5	-3.5	-2.8	-1.3	1.3
BMI without tail	1.4	7.3	14.3	-3.8	-3.2	-1.6	1.6
Body weight	1.2	5.2	12.6	-3.6	-2.8	-0.2	0.2
Weight adjusted by age	0.0	0.1	0.2	-0.3	-0.1	-0.4	0.4
Bone surface	0.8	1.6	3.2	-0.9	-1.8	-1.1	1.1
Bone volume	1.0	1.9	3.4	-1.1	-1.8	-1.3	1.3
Breakpoint value in progressive ratio session	0.0	0.1	0.2	0.4	0.4	-0.2	0.2
Number of licking bursts	0.6	1.7	4.0	2.0	1.5	-0.4	0.5
Context. condit. distance diff. score	0.2	0.3	0.6	0.5	0.8	0.3	-0.3
Locomotion velocity, session 1	0.3	0.3	0.5	-0.0	-0.5	-0.7	0.7
Locomotion distance, session 1	0.1	0.1	0.1	-0.3	-0.3	-0.4	0.4
Locomotion velocity, session 2	0.2	0.2	0.3	0.1	-0.5	-0.5	0.5
Locomotion distance, session 2	0.4	0.6	1.0	-1.0	-0.8	-0.5	0.5
Locomotion velocity, session 3	0.9	1.1	2.4	-1.5	-1.3	0.4	-0.4
Locomotion distance, session 3	0.1	0.2	0.4	-0.2	-0.7	0.3	-0.3
Stereotopy head waving bouts, day 3	0.6	0.7	1.4	-0.3	-0.4	-1.2	1.1
Stereotopy head waving duration, day 3	0.6	0.8	1.0	-0.7	-0.8	-1.0	1.0
Locomotion velocity, session 7	1.3	1.4	2.6	-0.1	0.6	1.6	-1.6
Locomotion distance, session 7	0.2	0.3	0.6	0.6	0.7	0.4	-0.4
Stereotopy head waving bouts, day 7	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.8	-0.8	-0.9	-0.0	0.0
Locomotion velocity, session 8	0.1	0.1	0.2	-0.4	-0.5	-0.0	0.0
Locomotion distance, session 8	0.0	0.0	0.0	-0.2	-0.1	-0.1	0.2
Degree of sensitization distance	0.3	0.4	1.2	0.4	1.1	-0.3	0.3
Degree of sensitization stereotypy	0.2	0.2	0.4	-0.3	-0.2	0.6	-0.6
Conditioned locomotion	0.4	0.4	0.8	0.0	0.4	0.9	-0.9
Cocaine response after cond. corrected	0.5	0.7	1.8	1.4	1.0	-0.1	0.1
Cocaine response after cond. not corrected	0.1	0.2	0.2	0.5	0.5	0.4	-0.4
Cocaine response before conditioning	1.2	1.4	2.9	-1.7	-1.2	0.8	-0.8
Saline control response	0.6	0.8	1.4	0.6	-0.3	-1.2	1.2
Bone: connectivity density	0.4	0.7	1.0	0.0	-0.8	-1.0	1.0
Bone: cortical apparent density	0.2	0.3	0.7	0.8	0.4	-0.5	0.5
Bone: cortical area	2.3	3.7	7.6	-2.2	-2.7	-1.1	1.1
Bone: cortical porosity	2.3	2.5	3.7	-1.9	-1.2	1.6	-1.5
Bone: cortical porosity	2.0	2.2	3.0	-1.5	-0.7	1.7	-1.7
Bone: cortical thickness	1.6	2.7	5.0	-1.6	-2.2	-1.3	1.3
Bone: cortical thickness	0.4	0.5	1.2	-0.8	-1.1	-0.4	0.4
Bone: cortical tissue density	0.2	0.4	0.7	0.8	0.5	-0.5	0.5
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.4	0.4	-0.3	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.3	0.6	0.1	-0.2
Condit. Reinf. active responses	0.8	1.0	2.0	0.4	-0.2	-1.4	1.4
Condit. Reinf. inactive responses	1.5	1.9	3.5	0.2	-0.8	-1.9	1.9
Incentive salience index mean	0.1	0.1	0.1	-0.3	-0.4	-0.4	0.4
Condit. Reinf. lever presses	0.7	1.0	1.7	-1.0	-1.3	-0.8	0.8
Condit. Reinf. active minus inactive responses	2.9	4.5	8.0	-0.3	-1.4	-2.8	2.8
Condit. Reinf. active-inactive response ratio	3.4	5.3	10.0	0.1	-1.2	-3.2	3.2
Condit. Reinf. active responses	2.1	2.9	5.0	-0.3	-1.3	-2.2	2.2
Condit. Reinf. inactive responses	0.2	0.3	0.4	-0.5	-0.3	0.6	-0.6
Condit. Reinf. lever presses	1.8	2.7	3.3	-1.0	-1.7	-1.8	1.8
Condit. Reinf. lever reinforcers received	1.8	2.6	4.6	0.0	-1.0	-2.2	2.1
Conditioned reinforcement - actives	0.2	0.9	1.2	1.0	1.1	0.8	-0.8
Conditioned reinforcement - inactives	0.2	0.7	1.0	1.0	0.7	-0.8	0.8
Conditioned locomotion	1.3	1.9	2.5	1.2	1.6	1.3	-1.3
Patch foraging indifference point 0 sec	0.5	1.5	2.0	-0.9	-1.0	-1.4	1.4
Patch foraging indifference point AUC	0.4	0.9	1.8	-1.3	-1.0	-0.6	0.6
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.6	-0.3	-0.1	0.1
Delay disc. indifference point, 16s delay	0.4	0.5	0.9	1.0	0.7	0.6	-0.6
Delay disc. indifference point, 2s delay	3.9	4.3	5.1	-2.0	-2.3	-2.0	2.0
Delay disc. indifference point, 24s delay	0.4	0.7	1.2	1.1	1.0	0.5	-0.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.1	-0.2	-0.4	0.4
Delay disc. indifference point, 8s delay	0.0	0.1	0.1	-0.0	-0.3	-0.3	0.3
Indifference point function ln k	0.3	0.8	1.5	-1.2	-1.1	-0.5	0.5
Indifference point function log k	0.3	0.8	1.5	-1.2	-1.1	-0.5	0.5
Patch foraging total patch changes 0 sec	0.6	1.9	2.8	-0.9	-1.0	-1.7	1.7
Patch foraging total patch changes 12 sec	0.4	0.5	0.9	0.4	0.1	-1.0	0.9
Patch foraging total patch changes 18 sec	0.2	0.4	0.7	0.4	0.2	-0.8	0.8
Patch foraging total patch changes 24 sec	0.3	1.1	2.2	-0.0	-0.3	-1.5	1.5
Patch foraging total patch changes 6 sec	1.2	2.0	3.6	-0.3	-0.8	-1.9	1.9
Patch foraging time to switch 0 sec	1.2	4.6	8.8	3.0	2.3	1.4	-1.5
Patch foraging water rate 0 sec	0.2	0.9	1.4	-1.2	-1.0	-0.8	0.8
Patch foraging water rate 12 sec	0.3	1.2	3.0	-1.7	-1.2	-0.4	0.4
Patch foraging water rate 18 sec	0.4	1.0	2.4	-1.6	-0.9	0.6	-0.6
Patch foraging water rate 24 sec	0.6	0.8	1.7	-1.3	-1.0	-0.5	0.5
Patch foraging water rate 6 sec	0.7	1.0	1.8	-0.5	-0.6	-1.3	1.3
Seeking ratio, delayed vs. immediate footshock	1.0	1.4	2.4	0.6	0.5	1.6	-1.6
Distance traveled before self-admin	0.0	0.1	0.3	0.6	0.2	0.0	-0.0
Distance traveled after self-admin	0.5	0.8	1.7	1.3	0.1	-0.9	0.9
Extensor digitorum longus weight	1.9	7.7	18.4	-4.3	-3.5	0.2	-0.2
Bone: elastic displacement	0.3	0.4	0.5	0.3	0.7	0.7	-0.7
Bone: elastic work	0.6	0.8	1.0	-0.4	-1.0	-1.0	1.0
Bone: endosteal estimation	0.4	1.0	2.3	-1.2	-1.5	-0.4	0.4
Bone: endosteal perimeter	0.1	0.3	0.6	-0.5	-0.8	0.4	-0.4
Epididymis fat weight	0.2	1.2	2.7	-1.6	-1.3	-0.4	0.4
Delta time in closed arm before/after self-admin	1.0	0.9	1.2	0.7	0.8	1.1	-1.1
Delta time in open arm before/after self-admin	4.2	5.0	5.9	-1.7	-2.3	-2.4	2.4
Diff in mean of infusions in LGA sessions	0.4	0.7	1.2	-0.0	-0.6	-1.1	1.1
Delay discount exponential model param	0.0	0.0	0.1	-0.3	0.0	0.2	-0.2
Extinction: sum of active levers before priming	0.2	0.3	0.7	0.8	0.7	-0.4	0.4
Active lever presses in extinction session 6	0.9	0.9	1.5	-1.2	-1.2	-0.5	0.5
Bone: final force	4.5	7.4	13.1	-2.7	-3.6	-2.2	2.2
Bone: final moment	4.2	6.8	11.6	-2.4	-3.4	-2.2	2.2
Food consumed during 24 hour testing period	1.2	2.4	2.7	-1.6	-1.7	-1.4	1.4
Glucose	0.1	0.1	0.4	-0.7	-0.1	-0.1	0.1
Heart weight	0.1	0.2	0.6	-0.8	-0.1	0.4	-0.4
Delay discount hyperbolic model param	0.1	0.2	0.3	0.0	0.4	0.5	-0.5
Intermittent access intake day 1-15 change	0.1	0.7	1.5	1.2	1.1	-0.4	0.4
Intermittent access intake escalation	0.1	0.6	1.2	1.1	0.9	-0.4	0.4
Intermittent access intake escalation 2	0.4	0.7	1.5	1.2	1.1	0.1	-0.1
Intermitt. access day 1 inactive lever presses	0.1	1.1	1.9	0.8	0.3	-1.4	1.4
Intermitt. access day 15 inactive lever presses	0.1	0.6	0.9	-0.9	-0.7	-0.6	0.6
Intermitt. access escalation Index	0.1	0.2	0.3	-0.4	-0.5	-0.4	0.4
Intermittent access day 1 total infusions	0.2	0.5	0.9	0.0	-0.2	-1.0	0.9
Intermittent access day 15 total infusions	0.4	0.9	1.1	1.0	0.7	-1.0	1.0
Intermittent access terminal intake (last 3 days)	0.5	0.8	1.3	0.8	0.3	-1.1	1.1
Intermittent access total infusions	0.5	0.5	0.9	-0.1	-0.6	-1.0	1.0
Intermittent access day 1 locomotion	0.2	0.4	0.7	0.3	-0.3	-0.8	0.8
Intermittent access day 15 total locomotion	0.2	0.9	1.6	0.7	-0.0	-1.3	1.3
Intermittent access total locomotion	0.8	0.9	1.5	-0.4	-0.9	-1.2	1.2
Intermittent access standard deviation	0.0	0.2	0.4	-0.0	0.0	-0.6	0.6
Left kidney weight	1.1	8.7	22.4	-4.7	-2.8	1.5	-1.5
Right kidney weight	1.1	7.7	21.0	-4.6	-2.9	0.8	-0.8
Cocaine induced anxiety	0.0	0.1	0.3	0.4	0.6	0.0	-0.0
Post-drug Anxiety	0.1	0.1	0.2	-0.5	0.0	0.3	-0.3
Baseline Anxiety	0.4	0.7	1.5	-1.2	-0.9	0.5	-0.5
Tail length	0.2	1.1	3.0	-1.7	-1.1	0.0	-0.0
Length with tail	0.4	2.0	3.0	-1.2	-0.6	1.7	-1.7
Length without tail	0.7	3.7	7.2	-0.3	0.5	2.7	-2.7
Times rat made contact with spout	0.5	0.5	0.8	-0.2	-0.7	-0.9	0.9
Lifetime Intake	0.3	0.4	0.6	-0.3	-0.4	-0.8	0.8
Liver weight, left	0.5	0.8	1.3	0.3	1.1	1.0	-1.0
Liver weight, right	0.9	1.6	2.4	0.4	1.3	1.5	-1.5
Locomotor activity	0.1	0.1	0.2	-0.2	0.1	0.5	-0.5
Locomotor testing distance	0.0	0.0	0.1	0.2	0.3	0.0	-0.0
Locomotor testing rearing	0.4	1.3	2.6	1.6	1.6	0.4	-0.4
Locomotion in novel chamber	0.4	0.6	1.0	-0.8	-1.0	-0.6	0.6
Locomotion in novel chamber post-restriction	0.5	1.4	2.0	1.4	0.5	-1.3	1.3
Fecal boli incidents, locomotor time 1	1.3	3.4	4.2	1.6	2.0	1.9	-1.9
Change in fecal boli incidents, locomotor task	2.3	2.4	4.3	-2.1	-2.0	-0.8	0.8
Time >=10cm from walls, locomotor time 1	0.3	0.4	0.6	0.7	0.2	-0.7	0.7
Bouts of movement, locomotor time 1	0.6	0.8	1.0	0.8	1.0	0.8	-0.8
Total resting periods, locomotor time 1	0.7	0.8	0.9	0.9	1.0	0.8	-0.8
Rest time, locomotor task time 1	1.2	2.0	3.0	0.9	1.0	1.7	-1.7
Distance moved, locomotor task time 1	1.2	3.4	5.4	-0.9	-1.4	-2.3	2.3
Vertical activity count, locomotor time 1	0.5	3.8	6.4	-0.9	-1.2	-2.5	2.5
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.2
Bouts of movement, locomotor time 2	0.3	0.9	1.6	1.2	0.1	-1.0	1.0
Total resting periods, locomotor time 2	0.1	0.4	0.8	0.9	0.0	-0.7	0.7
Rest time, locomotor task time 2	0.9	1.6	3.0	-0.6	0.3	1.7	-1.7
Distance moved, locomotor task time 2	2.4	3.2	6.1	0.8	-0.5	-2.5	2.5
Vertical activity count, locomotor time 2	1.2	2.8	5.4	0.9	-0.1	-2.3	2.3
Light reinforcement 1	0.4	1.6	2.1	0.9	1.2	1.4	-1.5
Light reinforcement 2	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2
Bone: marrow area	0.4	1.1	2.2	-1.3	-1.5	-0.4	0.4
Bone: maximum diameter	1.2	2.4	5.0	-1.9	-2.2	-0.6	0.6
Bone: maximum force	3.2	6.4	11.5	-2.5	-3.4	-2.0	2.0
Bone: maximum moment	3.0	5.8	10.0	-2.3	-3.2	-2.0	2.0
Mean time between licks in bursts	0.2	1.0	2.2	1.2	1.5	-0.2	0.2
Mean num. licks in bursts	0.5	1.4	2.8	-1.7	-1.6	-0.2	0.1
Cd content in liver	0.7	0.8	1.1	1.0	0.2	-1.1	1.1
Co content in liver	1.9	2.3	4.6	-1.0	-2.2	-1.3	1.3
Cu content in liver	2.9	3.4	5.8	-1.7	-2.4	-1.5	1.5
Fe content in liver	0.3	0.3	0.6	0.3	0.1	-0.8	0.8
K content in liver	2.6	2.5	6.0	-1.8	-2.5	-0.6	0.6
Mg content in liver	0.7	0.8	1.2	-1.1	-0.9	0.7	-0.7
Mn content in liver	0.1	0.2	0.2	-0.3	-0.4	0.4	-0.4
Na content in liver	2.5	2.8	7.1	-2.7	-1.9	0.5	-0.5
Rb content in liver	1.0	1.2	1.9	-0.6	-0.8	-1.4	1.4
Se content in liver	0.1	0.1	0.2	0.3	-0.4	-0.4	0.4
Sr content in liver	0.1	0.1	0.2	-0.1	-0.4	0.1	-0.1
Zn content in liver	1.1	1.2	2.2	-1.1	-1.5	-0.9	0.9
Bone: minimum diameter	0.8	1.5	3.2	-1.2	-1.8	-0.9	0.9
Time in familiar zone, hab. session 1	0.7	0.8	1.5	0.1	-0.4	-1.2	1.2
Time in novel zone, hab. session 1	2.2	2.4	4.5	-0.0	0.9	2.1	-2.1
Total zone transitions, hab. session 1	1.1	1.6	3.5	-1.9	-1.5	-0.5	0.5
Total locomotion distance, hab. session 1	1.9	2.7	7.4	-2.7	-1.7	-0.5	0.5
Locomotion velocity, hab. session 1	1.7	2.4	6.5	-2.5	-1.5	-0.7	0.7
Time in familiar zone, hab. session 2	2.1	2.4	3.9	-0.4	-1.3	-2.0	2.0
Time in novel zone, hab. session 2	1.4	1.5	2.1	0.3	1.3	1.4	-1.4
Total zone transitions, hab. session 2	0.4	0.5	1.2	-1.1	-0.8	0.1	-0.2
Total locomotion distance, hab. session 2	0.6	0.8	2.3	-1.5	-1.0	-0.3	0.3
Locomotion velocity, hab. session 2	1.0	1.3	3.3	-1.8	-1.3	-0.4	0.4
Novel to familiar place preference ratio	0.8	1.0	1.8	1.3	1.0	-0.7	0.7
Novelty place preference	0.8	1.1	1.8	1.4	0.9	-0.9	0.9
Time in novel zone, NPP test	1.1	1.3	2.0	1.4	1.0	-1.1	1.0
Total zone transitions, NPP test	0.8	1.2	2.9	-1.7	-1.3	0.3	-0.3
Total locomotion distance, NPP test	0.6	0.8	2.7	-1.6	-0.6	0.3	-0.3
Locomotion velocity, NPP test	0.8	1.2	3.2	-1.8	-0.8	0.7	-0.7
Intraocular pressure	0.4	0.7	1.9	1.4	0.7	0.4	-0.4
Delta distance traveled before/after self-admin	0.5	0.5	0.8	0.7	-0.0	-0.9	0.9
Delta ambulatory time before/after self-admin	0.5	0.9	1.6	0.7	-0.2	-1.3	1.2
Parametrial fat weight	3.6	8.5	15.8	-4.0	-3.5	-1.7	1.8
Pavlov. Cond. lever latency	0.4	0.4	1.2	1.1	0.7	-0.2	0.2
Pavlov. Cond. magazine entry latency	0.8	1.0	1.6	-1.3	0.1	1.1	-1.1
Pavlov. Cond. change in total contacts	0.5	0.5	1.0	-0.4	-0.0	1.0	-1.0
Pavlov. Cond. index score	0.3	0.4	0.9	-0.9	-0.2	0.6	-0.6
Pavlov. Cond. latency score	0.4	0.6	1.4	-1.2	-0.5	0.5	-0.5
Pavlov. Cond. lever contacts	0.5	0.6	1.4	-1.2	-0.7	0.4	-0.4
Pavlov. Cond. magazine entry number	0.5	0.7	1.0	0.5	-0.6	-1.0	1.0
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.8	0.8	-0.1	-1.4	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.1	-1.0	-0.3	0.5	-0.5
Pavlov. Cond. response bias	0.5	0.6	1.1	-0.5	0.4	1.0	-1.0
Pavlov. Cond. lever latency	0.8	1.1	1.8	1.0	1.3	0.9	-0.9
Pavlov. Cond. magazine entry latency	1.6	2.2	3.6	1.7	1.9	1.1	-1.1
Pavlov. Cond. change in total contacts	0.3	0.7	1.4	0.2	-0.4	-1.2	1.2
Pavlov. Cond. index score	0.1	0.1	0.2	0.4	0.3	-0.2	0.2
Pavlov. Cond. latency score	0.0	0.0	0.1	0.3	0.2	-0.0	0.0
Pavlov. Cond. lever contacts	0.7	1.0	1.7	-1.1	-1.3	-0.7	0.7
Pavlov. Cond. magazine entry number	1.0	1.3	3.1	-1.8	-1.3	-0.3	0.3
Pavlov. Cond. intertrial magazine entries	1.0	2.2	5.3	-2.3	-1.8	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	0.7	0.6	-0.1	0.1
Pavlov. Cond. response bias	0.2	0.3	0.5	0.2	-0.2	-0.7	0.7
Time in closed arm before self-admin	0.4	0.7	1.9	0.8	1.4	0.4	-0.4
Time in closed arm after self-admin	3.6	4.1	5.0	1.8	2.2	2.0	-2.0
Time in open arm before self-admin	0.4	0.5	1.1	-0.0	-0.2	1.0	-1.0
Time in open arm after self-admin	5.5	6.1	8.0	-2.0	-2.8	-2.5	2.5
Bone: periosteal estimation	1.8	4.2	8.8	-2.2	-3.0	-1.2	1.2
Bone: periosteal perimeter	0.5	0.9	1.7	-1.3	-1.3	0.3	-0.3
Bone: post-yield work	2.1	3.5	8.4	-2.9	-2.4	-0.3	0.3
Progressive ratio test 1 active lever presses	0.2	0.4	0.8	-0.0	-0.1	-0.9	0.9
Progressive ratio test 1 breakpoint	0.2	0.4	0.9	0.0	-0.0	-0.9	0.9
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	-0.2	-0.1	-0.7	0.7
Progressive ratio test 2 active lever presses	0.7	1.0	2.4	1.5	1.2	0.1	-0.2
Progressive ratio test 2 breakpoint	0.6	0.8	2.0	1.4	1.1	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.1	0.4	0.7	0.3	0.6	0.8	-0.8
Incentive Sensitization - Responses	0.4	1.0	2.1	1.4	1.2	0.6	-0.6
Incentive Sensitization - Breakpoint	0.3	0.7	1.5	1.2	1.0	0.5	-0.5
Sum of active levers in priming session hrs 5-6	0.6	0.6	0.9	-0.9	-0.7	0.6	-0.7
Progressive ratio	0.4	1.1	2.0	-0.2	0.5	1.4	-1.4
Food seeking constrained by brief footshock	0.0	0.0	0.1	-0.2	0.3	0.2	-0.2
Seeking ratio, punishment vs. effort	0.2	0.5	0.8	-0.4	-0.7	-0.9	0.9
Retroperitoneal fat weight	0.6	2.6	8.2	-2.9	-0.9	0.9	-0.8
Reaction time number correct	0.4	1.4	2.6	1.6	1.4	0.7	-0.7
Reaction time mean minus median	0.0	0.0	0.1	-0.3	-0.2	-0.1	0.1
Reaction time mean minus median AUC	0.0	0.0	0.1	0.3	0.1	-0.0	0.0
Reaction time num false alarms	0.1	0.2	0.4	0.6	0.1	-0.5	0.5
Reaction time num false alarms AUC	0.0	0.0	0.0	0.1	-0.1	0.0	-0.0
Reaction time trials correct on left	0.4	1.4	2.6	1.6	1.4	0.7	-0.7
Reaction time trials on left	0.4	1.4	2.6	1.6	1.4	0.8	-0.8
Reaction time mean	0.1	0.2	0.2	-0.4	0.1	0.5	-0.5
Reaction time mean AUC	0.1	0.3	0.6	-0.1	0.3	0.7	-0.7
Median of all reaction times	0.1	0.2	0.4	-0.4	0.2	0.6	-0.6
Reaction time omissions	0.9	1.4	2.6	0.1	0.5	1.6	-1.6
Reaction time false alarm rate	0.2	0.2	0.3	-0.3	-0.6	-0.5	0.5
Reaction time premature initiation rate	1.3	2.1	3.9	-0.1	0.6	2.0	-2.0
Reaction time premature initiations	1.3	3.8	6.4	0.8	1.4	2.5	-2.5
Std. dev. reaction times	0.0	0.1	0.2	-0.2	0.2	0.5	-0.5
Reaction time trials completed	0.4	1.4	2.6	1.6	1.4	0.8	-0.8
Reaction time trials AUC	0.3	1.2	2.1	1.5	1.3	0.6	-0.6
Run reversals in cocaine runway, females	1.2	1.4	2.6	-1.6	-1.0	1.0	-1.0
Run reversals in cocaine runway, males	0.0	0.0	0.1	0.0	-0.3	0.2	-0.2
Latency to leave start box in cocaine runway	1.2	1.7	2.4	-1.3	-1.6	-1.1	1.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.1	-0.1	-0.1	-0.4	0.4
Latency to leave start box in cocaine runway, M	2.3	2.2	4.0	-1.7	-2.0	-0.9	0.9
Std. dev. time between licks in bursts	0.1	0.2	0.3	-0.0	0.2	-0.6	0.6
Total sessions with >9 infusions	0.4	0.5	0.6	-0.6	-0.6	-0.8	0.8
Short access day 1 total inactive lever presses	0.6	1.2	2.4	-0.2	0.4	1.5	-1.5
Short access day 10 total inactive lever presses	0.0	0.3	0.6	0.8	0.6	-0.2	0.2
Short access day 1 total infusions	0.6	1.1	1.8	1.0	1.3	0.9	-0.9
Short access day 10 total infusions	0.2	0.3	0.6	0.3	0.2	-0.7	0.7
Short access total infusions	0.1	0.1	0.2	-0.3	-0.1	-0.4	0.4
Short access day 1 locomotion	0.3	0.5	1.5	1.2	0.7	-0.1	0.0
Short access day 10 total locomotion	0.5	2.0	3.6	-0.2	-0.8	-1.9	1.9
Short access total locomotion	0.9	1.4	2.1	-0.7	-0.9	-1.4	1.4
One hour access (0.3 mA shock)	0.2	0.3	0.4	0.3	0.5	-0.6	0.6
Compulsive drug intake	0.3	0.4	0.9	-1.0	-0.8	-0.2	0.2
One hour access (shock baseline)	0.2	0.4	0.6	0.5	0.4	-0.8	0.8
Social response proportion	0.5	0.6	1.7	0.7	1.3	0.5	-0.5
Social responses	0.7	0.9	1.5	0.7	1.2	0.9	-0.9
Social time	0.6	0.9	1.7	1.3	1.3	0.4	-0.4
Soleus weight	1.8	5.4	10.4	-3.2	-2.9	-1.2	1.2
Bone: stiffness	4.0	7.3	14.0	-2.9	-3.7	-1.8	1.8
Tibialis anterior weight	4.0	13.9	29.8	-5.5	-4.8	-1.2	1.2
Time to tail flick, vehicle, before self-admin	0.5	0.6	1.5	-1.2	-0.7	0.4	-0.4
Time to tail flick, vehicle, after self-admin	0.2	0.4	0.7	-0.0	0.4	0.8	-0.8
Time to tail flick, test, before self-admin	0.6	0.7	2.4	-1.6	-0.7	0.2	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.5	0.2	0.7	-0.2	0.2
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.0	-0.2	-0.4	0.4
Delta time to tail flick, test, before/after SA	0.1	0.1	0.2	0.4	0.4	-0.3	0.3
Tibia length	0.0	0.1	0.2	-0.0	-0.4	-0.3	0.3
Ambulatory time before self-admin	0.1	0.3	1.0	1.0	0.3	-0.1	0.1
Ambulatory time after self-admin	0.7	1.0	3.1	1.8	0.4	-0.7	0.7
Bone: tissue strength	0.2	0.2	0.4	-0.7	-0.6	0.1	-0.1
Total heroin consumption	0.0	0.0	0.0	-0.1	0.0	-0.1	0.0
Bone: trabecular number	0.4	0.7	0.9	-0.6	-0.9	-0.9	0.9
Bone: trabecular spacing	1.2	1.7	2.6	0.6	1.2	1.6	-1.6
Bone: trabecular thickness	1.1	1.6	1.9	-1.0	-1.2	-1.4	1.4
Bone: trabecular tissue density	0.3	0.5	1.0	-1.0	-0.7	0.6	-0.6
Water consumed over 24 hours	0.5	1.0	1.4	1.2	0.9	1.0	-1.0
Number of responses in last shaping day	0.3	0.3	0.6	0.3	0.8	0.6	-0.6