Hub : Genes

LOC120099768

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC120099768 0.21 0.1 0.0e+00 0.21 0.22 0.22 0.22 5.5e-23 1.6e-23 2.2e-24 9.5e-24
2 Liver intron excision ratio chr1_85186709_85200351 0.8 0.02 0.0e+00 0.36 0.36 0.38 0.39 1.4e-41 3.9e-41 3.0e-44 1.9e-45
3 Liver intron excision ratio chr1_85200528_85204893 0.82 0 0.0e+00 0.39 0.38 0.41 0.41 1.7e-45 7.3e-45 6.6e-49 2.2e-49

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.00.0-0.20.2-0.2
Area under the delay curve0.60.70.8-0.70.9-0.9
BMI with tail0.72.52.81.7-1.51.5
BMI without tail1.95.86.22.5-2.42.3
Body weight3.013.313.63.7-3.63.6
Weight adjusted by age0.91.41.51.2-1.21.2
Bone surface0.91.71.81.2-1.31.3
Bone volume0.40.80.90.8-0.90.9
Breakpoint value in progressive ratio session3.33.94.3-1.82.1-2.1
Number of licking bursts1.42.32.71.6-1.41.4
Context. condit. distance diff. score0.10.10.10.3-0.30.2
Locomotion velocity, session 10.60.60.7-0.70.8-0.8
Locomotion distance, session 10.10.10.10.2-0.30.3
Locomotion velocity, session 21.11.31.61.2-1.11.1
Locomotion distance, session 21.82.62.81.7-1.61.6
Locomotion velocity, session 30.10.10.10.4-0.30.3
Locomotion distance, session 30.00.00.1-0.20.1-0.0
Stereotopy head waving bouts, day 30.00.00.00.1-0.10.1
Stereotopy head waving duration, day 30.00.10.1-0.20.3-0.3
Locomotion velocity, session 70.80.91.0-1.00.9-0.9
Locomotion distance, session 70.00.00.0-0.10.1-0.1
Stereotopy head waving bouts, day 70.40.50.50.7-0.70.7
Stereotopy head waving duration, day 70.40.40.50.6-0.70.7
Locomotion velocity, session 80.00.00.0-0.10.2-0.2
Locomotion distance, session 80.50.70.70.8-0.80.8
Degree of sensitization distance0.00.00.00.2-0.00.0
Degree of sensitization stereotypy1.21.31.31.1-1.21.2
Conditioned locomotion0.00.00.00.2-0.20.2
Cocaine response after cond. corrected0.10.10.1-0.20.3-0.3
Cocaine response after cond. not corrected0.40.40.50.7-0.60.6
Cocaine response before conditioning4.75.65.92.3-2.42.4
Saline control response1.82.42.51.5-1.61.6
Bone: connectivity density0.00.00.0-0.00.1-0.1
Bone: cortical apparent density0.50.70.7-0.90.8-0.8
Bone: cortical area1.72.62.61.6-1.61.6
Bone: cortical porosity0.00.00.00.1-0.20.2
Bone: cortical porosity0.30.40.40.6-0.60.6
Bone: cortical thickness0.00.00.00.2-0.10.1
Bone: cortical thickness0.30.30.30.6-0.50.5
Bone: cortical tissue density0.60.90.9-1.00.9-0.9
Condit. Reinf. active minus inactive responses0.50.60.80.9-0.70.7
Condit. Reinf. active-inactive response ratio0.60.60.80.9-0.70.7
Condit. Reinf. active responses0.40.50.70.8-0.70.7
Condit. Reinf. inactive responses0.00.00.0-0.20.1-0.1
Incentive salience index mean0.70.81.01.0-0.90.8
Condit. Reinf. lever presses0.40.50.70.8-0.70.7
Condit. Reinf. active minus inactive responses0.30.40.50.6-0.70.7
Condit. Reinf. active-inactive response ratio0.30.40.40.5-0.60.6
Condit. Reinf. active responses0.30.40.40.6-0.60.6
Condit. Reinf. inactive responses0.00.00.0-0.20.2-0.1
Condit. Reinf. lever presses1.01.31.41.1-1.21.2
Condit. Reinf. lever reinforcers received0.50.70.70.8-0.80.9
Conditioned reinforcement - actives1.32.22.41.5-1.51.4
Conditioned reinforcement - inactives0.40.60.60.8-0.80.8
Conditioned locomotion0.40.50.50.7-0.70.6
Patch foraging indifference point 0 sec0.00.00.0-0.20.2-0.2
Patch foraging indifference point AUC2.94.24.82.2-2.02.0
Delay disc. indifference point, 0s delay0.00.10.1-0.30.2-0.2
Delay disc. indifference point, 16s delay1.01.11.3-0.81.1-1.1
Delay disc. indifference point, 2s delay0.60.70.7-0.80.9-0.9
Delay disc. indifference point, 24s delay0.00.00.0-0.10.2-0.2
Delay disc. indifference point, 4s delay0.20.20.30.5-0.40.4
Delay disc. indifference point, 8s delay1.31.51.6-1.11.3-1.3
Indifference point function ln k1.12.02.6-1.61.3-1.3
Indifference point function log k1.12.02.6-1.61.3-1.3
Patch foraging total patch changes 0 sec0.00.00.0-0.10.1-0.1
Patch foraging total patch changes 12 sec0.91.21.41.2-1.11.1
Patch foraging total patch changes 18 sec0.91.41.41.2-1.21.2
Patch foraging total patch changes 24 sec1.22.12.31.5-1.41.4
Patch foraging total patch changes 6 sec0.40.60.80.9-0.70.7
Patch foraging time to switch 0 sec2.24.64.7-2.12.2-2.2
Patch foraging water rate 0 sec1.73.63.61.9-1.91.9
Patch foraging water rate 12 sec0.00.10.10.2-0.30.3
Patch foraging water rate 18 sec0.00.00.0-0.10.0-0.0
Patch foraging water rate 24 sec0.00.00.0-0.10.0-0.0
Patch foraging water rate 6 sec4.05.86.02.3-2.52.5
Seeking ratio, delayed vs. immediate footshock1.21.52.1-1.51.1-1.1
Distance traveled before self-admin0.20.30.30.3-0.60.6
Distance traveled after self-admin0.50.60.7-0.80.8-0.8
Extensor digitorum longus weight2.39.09.32.9-3.13.0
Bone: elastic displacement2.63.03.0-1.71.7-1.7
Bone: elastic work0.00.10.1-0.20.3-0.2
Bone: endosteal estimation0.40.91.00.9-1.01.0
Bone: endosteal perimeter0.30.50.60.7-0.80.8
Epididymis fat weight0.51.61.7-1.31.2-1.2
Delta time in closed arm before/after self-admin0.00.00.0-0.20.1-0.1
Delta time in open arm before/after self-admin0.30.30.30.5-0.50.5
Diff in mean of infusions in LGA sessions0.81.01.2-1.11.0-1.0
Delay discount exponential model param0.40.50.50.6-0.70.7
Extinction: sum of active levers before priming0.00.00.00.00.0-0.0
Active lever presses in extinction session 61.41.42.11.4-1.01.0
Bone: final force1.93.13.21.7-1.81.8
Bone: final moment2.33.74.01.8-2.02.0
Food consumed during 24 hour testing period2.94.04.2-2.12.0-2.0
Glucose3.04.84.9-2.12.2-2.2
Heart weight0.30.40.60.7-0.50.6
Delay discount hyperbolic model param0.30.40.40.5-0.70.7
Intermittent access intake day 1-15 change0.10.30.40.6-0.50.5
Intermittent access intake escalation0.30.70.70.9-0.80.8
Intermittent access intake escalation 20.00.00.0-0.0-0.10.0
Intermitt. access day 1 inactive lever presses0.00.10.10.3-0.20.2
Intermitt. access day 15 inactive lever presses0.51.01.01.0-1.01.0
Intermitt. access escalation Index0.00.00.10.00.2-0.3
Intermittent access day 1 total infusions0.61.01.01.0-1.01.0
Intermittent access day 15 total infusions0.20.20.40.6-0.40.4
Intermittent access terminal intake (last 3 days)0.10.10.20.4-0.30.3
Intermittent access total infusions0.70.81.01.0-0.90.9
Intermittent access day 1 locomotion0.00.00.0-0.20.1-0.1
Intermittent access day 15 total locomotion0.00.10.1-0.30.2-0.2
Intermittent access total locomotion0.10.10.10.2-0.40.4
Intermittent access standard deviation0.20.40.5-0.40.7-0.7
Left kidney weight7.534.835.25.8-5.95.9
Right kidney weight6.027.127.35.2-5.25.2
Cocaine induced anxiety0.10.20.3-0.50.3-0.3
Post-drug Anxiety0.20.20.2-0.50.4-0.4
Baseline Anxiety1.11.21.3-1.11.1-1.1
Tail length2.59.69.73.1-3.13.1
Length with tail1.66.86.92.6-2.62.6
Length without tail0.72.32.41.6-1.51.5
Times rat made contact with spout0.80.90.9-1.00.9-1.0
Lifetime Intake1.11.31.51.2-1.11.1
Liver weight, left6.911.411.53.3-3.43.4
Liver weight, right1.93.33.31.8-1.81.8
Locomotor activity1.32.02.11.4-1.41.4
Locomotor testing distance1.01.71.81.3-1.31.3
Locomotor testing rearing5.110.210.73.3-3.23.2
Locomotion in novel chamber3.84.95.0-2.22.2-2.2
Locomotion in novel chamber post-restriction0.81.31.4-1.11.2-1.2
Fecal boli incidents, locomotor time 10.00.00.0-0.1-0.00.0
Change in fecal boli incidents, locomotor task1.21.21.3-1.01.2-1.1
Time >=10cm from walls, locomotor time 10.10.10.1-0.30.3-0.3
Bouts of movement, locomotor time 10.70.80.9-0.81.0-0.9
Total resting periods, locomotor time 12.32.62.8-1.51.7-1.6
Rest time, locomotor task time 10.20.20.2-0.50.5-0.5
Distance moved, locomotor task time 10.40.50.70.8-0.70.7
Vertical activity count, locomotor time 10.00.00.10.3-0.10.1
Time >=10cm from walls, locomotor time 20.00.00.00.00.0-0.0
Bouts of movement, locomotor time 21.72.62.9-1.51.7-1.7
Total resting periods, locomotor time 21.83.13.2-1.71.8-1.8
Rest time, locomotor task time 21.11.41.9-1.41.1-1.1
Distance moved, locomotor task time 21.92.22.41.6-1.51.5
Vertical activity count, locomotor time 20.91.21.51.2-1.01.0
Light reinforcement 10.40.90.91.0-1.00.9
Light reinforcement 20.50.70.80.9-0.80.8
Bone: marrow area0.51.11.21.0-1.11.1
Bone: maximum diameter4.07.47.82.8-2.72.7
Bone: maximum force1.12.02.01.4-1.41.4
Bone: maximum moment1.42.42.51.5-1.61.6
Mean time between licks in bursts0.00.00.00.1-0.00.0
Mean num. licks in bursts2.84.45.1-2.32.0-2.0
Cd content in liver0.20.30.4-0.60.5-0.5
Co content in liver0.50.60.7-0.80.7-0.7
Cu content in liver1.31.51.71.1-1.31.3
Fe content in liver3.44.14.32.0-2.12.1
K content in liver1.71.71.81.2-1.31.3
Mg content in liver2.12.12.21.4-1.51.5
Mn content in liver0.70.70.80.9-0.80.8
Na content in liver0.00.00.00.1-0.10.1
Rb content in liver1.01.11.30.9-1.11.2
Se content in liver7.18.49.13.0-2.82.8
Sr content in liver1.00.81.0-0.71.0-1.0
Zn content in liver1.92.12.31.5-1.41.4
Bone: minimum diameter1.32.32.51.4-1.61.6
Time in familiar zone, hab. session 10.10.10.20.3-0.40.4
Time in novel zone, hab. session 10.70.70.70.8-0.80.8
Total zone transitions, hab. session 10.20.20.30.5-0.50.5
Total locomotion distance, hab. session 10.10.20.2-0.50.4-0.4
Locomotion velocity, hab. session 10.71.01.0-1.01.0-1.0
Time in familiar zone, hab. session 20.00.00.0-0.10.2-0.2
Time in novel zone, hab. session 20.20.20.20.4-0.40.4
Total zone transitions, hab. session 20.91.11.21.0-1.11.1
Total locomotion distance, hab. session 20.30.40.5-0.70.7-0.6
Locomotion velocity, hab. session 20.20.20.2-0.50.5-0.4
Novel to familiar place preference ratio1.01.11.11.0-1.11.1
Novelty place preference1.01.01.10.9-1.11.1
Time in novel zone, NPP test1.01.11.11.0-1.11.1
Total zone transitions, NPP test0.20.30.30.6-0.50.6
Total locomotion distance, NPP test0.00.10.10.2-0.20.3
Locomotion velocity, NPP test0.10.10.10.3-0.30.4
Intraocular pressure0.10.20.2-0.40.4-0.4
Delta distance traveled before/after self-admin1.01.01.2-0.81.1-1.1
Delta ambulatory time before/after self-admin0.70.91.0-0.81.0-1.0
Parametrial fat weight0.81.91.9-1.41.4-1.4
Pavlov. Cond. lever latency0.91.11.3-1.11.0-1.0
Pavlov. Cond. magazine entry latency0.70.91.11.0-0.90.9
Pavlov. Cond. change in total contacts0.10.10.1-0.30.3-0.3
Pavlov. Cond. index score1.11.41.61.3-1.11.1
Pavlov. Cond. latency score0.50.60.80.9-0.70.7
Pavlov. Cond. lever contacts0.70.80.90.9-0.90.9
Pavlov. Cond. magazine entry number0.81.01.2-1.10.9-0.9
Pavlov. Cond. intertrial magazine entries0.20.20.4-0.60.4-0.4
Pavlov. Cond. lever-magazine prob. diff.1.21.41.71.3-1.21.1
Pavlov. Cond. response bias2.32.83.31.8-1.61.6
Pavlov. Cond. lever latency0.20.20.2-0.50.5-0.5
Pavlov. Cond. magazine entry latency0.00.00.00.0-0.00.0
Pavlov. Cond. change in total contacts0.00.10.1-0.30.3-0.2
Pavlov. Cond. index score0.10.10.10.3-0.30.3
Pavlov. Cond. latency score0.00.00.0-0.10.1-0.1
Pavlov. Cond. lever contacts0.40.60.60.8-0.80.8
Pavlov. Cond. magazine entry number0.10.20.20.4-0.40.4
Pavlov. Cond. intertrial magazine entries0.20.20.30.5-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.10.20.20.4-0.40.4
Pavlov. Cond. response bias0.40.50.50.7-0.70.7
Time in closed arm before self-admin0.10.10.10.3-0.20.2
Time in closed arm after self-admin0.30.30.3-0.60.5-0.5
Time in open arm before self-admin0.10.10.2-0.40.3-0.3
Time in open arm after self-admin0.00.00.0-0.00.0-0.0
Bone: periosteal estimation1.32.72.81.6-1.71.7
Bone: periosteal perimeter1.22.02.11.4-1.51.5
Bone: post-yield work0.00.10.10.2-0.30.3
Progressive ratio test 1 active lever presses1.21.41.51.1-1.21.2
Progressive ratio test 1 breakpoint0.91.11.21.0-1.11.1
Progressive ratio test 1 inactive lever presses2.02.93.11.6-1.71.7
Progressive ratio test 2 active lever presses1.41.61.91.4-1.21.2
Progressive ratio test 2 breakpoint1.61.82.11.5-1.31.3
Progressive ratio test 2 inactive lever presses1.62.62.71.5-1.61.6
Incentive Sensitization - Responses0.71.01.21.1-0.90.9
Incentive Sensitization - Breakpoint0.70.91.21.1-0.90.9
Sum of active levers in priming session hrs 5-60.80.80.9-0.70.9-0.9
Progressive ratio0.00.00.0-0.20.1-0.1
Food seeking constrained by brief footshock1.41.72.4-1.51.2-1.2
Seeking ratio, punishment vs. effort0.30.40.5-0.70.6-0.6
Retroperitoneal fat weight0.94.04.1-1.92.0-2.0
Reaction time number correct1.12.22.31.5-1.51.5
Reaction time mean minus median0.41.01.2-1.10.9-0.9
Reaction time mean minus median AUC0.00.00.1-0.30.1-0.1
Reaction time num false alarms4.66.67.12.7-2.52.5
Reaction time num false alarms AUC3.35.15.42.3-2.22.2
Reaction time trials correct on left1.12.22.31.5-1.51.5
Reaction time trials on left1.22.22.41.5-1.51.5
Reaction time mean1.42.22.7-1.61.4-1.4
Reaction time mean AUC1.32.12.6-1.61.4-1.4
Median of all reaction times1.21.72.1-1.41.3-1.3
Reaction time omissions0.00.00.0-0.00.0-0.0
Reaction time false alarm rate0.60.80.91.0-0.90.9
Reaction time premature initiation rate2.63.53.7-1.91.9-1.9
Reaction time premature initiations0.71.21.3-1.11.1-1.1
Std. dev. reaction times0.71.21.6-1.31.0-1.0
Reaction time trials completed1.22.22.41.5-1.51.5
Reaction time trials AUC1.42.72.91.7-1.61.6
Run reversals in cocaine runway, females2.62.63.1-1.81.5-1.5
Run reversals in cocaine runway, males0.90.90.90.9-1.01.0
Latency to leave start box in cocaine runway0.60.70.7-0.80.8-0.8
Latency to leave start box in cocaine runway, F0.40.40.4-0.70.6-0.7
Latency to leave start box in cocaine runway, M0.00.00.10.3-0.20.2
Std. dev. time between licks in bursts0.60.80.91.0-0.90.9
Total sessions with >9 infusions2.32.82.91.6-1.71.7
Short access day 1 total inactive lever presses2.02.62.91.7-1.61.6
Short access day 10 total inactive lever presses0.51.21.4-1.21.0-1.0
Short access day 1 total infusions1.01.31.41.2-1.11.1
Short access day 10 total infusions2.93.74.12.0-1.91.8
Short access total infusions1.51.92.21.5-1.31.3
Short access day 1 locomotion2.53.13.21.8-1.81.8
Short access day 10 total locomotion0.20.30.5-0.70.5-0.5
Short access total locomotion0.20.20.30.4-0.50.5
One hour access (0.3 mA shock)0.00.00.00.2-0.20.2
Compulsive drug intake0.20.20.20.4-0.40.4
One hour access (shock baseline)0.20.30.50.7-0.50.5
Social response proportion1.11.31.31.1-1.11.1
Social responses3.64.64.72.2-2.12.1
Social time0.10.10.10.3-0.30.3
Soleus weight0.51.61.71.3-1.21.2
Bone: stiffness2.64.24.32.0-2.12.1
Tibialis anterior weight2.89.410.03.2-3.03.0
Time to tail flick, vehicle, before self-admin0.00.00.00.1-0.10.1
Time to tail flick, vehicle, after self-admin0.20.20.3-0.50.4-0.4
Time to tail flick, test, before self-admin1.21.21.7-1.31.0-1.0
Time to tail flick, test, after self-admin0.10.20.2-0.40.4-0.4
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.20.1-0.1
Delta time to tail flick, test, before/after SA0.30.30.50.7-0.50.5
Tibia length3.28.78.92.9-3.03.0
Ambulatory time before self-admin0.10.20.30.3-0.50.5
Ambulatory time after self-admin0.50.60.7-0.80.7-0.7
Bone: tissue strength0.10.10.2-0.40.3-0.3
Total heroin consumption0.10.10.10.3-0.30.2
Bone: trabecular number0.10.10.1-0.30.4-0.4
Bone: trabecular spacing0.00.00.00.1-0.10.1
Bone: trabecular thickness0.50.60.80.9-0.70.7
Bone: trabecular tissue density0.00.00.1-0.20.2-0.2
Water consumed over 24 hours0.40.50.6-0.80.7-0.7
Number of responses in last shaping day1.51.72.11.5-1.21.2