Hub : Genes

LOC120098652

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC gene expression LOC120098652 0.07 0.04 2.3e-03 0.05 0.06 0.06 0.05 4.8e-03 2.5e-03 2.1e-03 3.6e-03
2 Brain gene expression LOC120098652 0.04 0.03 1.2e-04 0.04 0.04 0.04 0.04 2.7e-04 2.0e-04 2.9e-04 2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.03.64.42.1-1.7
Area under the delay curve0.10.20.2-0.50.3
BMI with tail2.27.67.8-2.72.8
BMI without tail0.00.20.2-0.40.5
Body weight0.41.72.0-1.21.4
Weight adjusted by age1.44.04.7-1.82.2
Bone surface1.52.93.71.9-1.4
Bone volume2.95.87.42.7-2.1
Breakpoint value in progressive ratio session0.10.10.20.1-0.5
Number of licking bursts0.10.40.60.5-0.8
Context. condit. distance diff. score3.13.85.9-2.41.3
Locomotion velocity, session 10.40.40.50.7-0.6
Locomotion distance, session 10.10.10.2-0.50.0
Locomotion velocity, session 20.00.00.0-0.2-0.0
Locomotion distance, session 20.30.50.7-0.90.5
Locomotion velocity, session 31.51.71.7-1.31.3
Locomotion distance, session 30.10.10.1-0.40.1
Stereotopy head waving bouts, day 30.30.40.5-0.70.5
Stereotopy head waving duration, day 30.70.91.1-1.00.8
Locomotion velocity, session 70.70.81.3-1.20.5
Locomotion distance, session 70.20.30.50.1-0.7
Stereotopy head waving bouts, day 70.30.40.4-0.60.6
Stereotopy head waving duration, day 70.20.30.40.6-0.4
Locomotion velocity, session 80.91.11.9-1.40.5
Locomotion distance, session 81.42.03.6-1.90.7
Degree of sensitization distance0.10.10.20.1-0.5
Degree of sensitization stereotypy0.20.30.4-0.40.6
Conditioned locomotion0.10.10.10.3-0.1
Cocaine response after cond. corrected2.23.34.1-2.01.5
Cocaine response after cond. not corrected1.72.52.9-1.71.4
Cocaine response before conditioning1.82.12.81.7-1.2
Saline control response1.62.23.41.0-1.9
Bone: connectivity density1.82.82.91.7-1.6
Bone: cortical apparent density0.00.00.1-0.3-0.0
Bone: cortical area0.30.60.70.9-0.6
Bone: cortical porosity0.00.00.0-0.00.2
Bone: cortical porosity0.10.20.20.5-0.3
Bone: cortical thickness0.00.10.20.4-0.1
Bone: cortical thickness0.00.00.0-0.20.0
Bone: cortical tissue density0.00.10.1-0.40.0
Condit. Reinf. active minus inactive responses0.60.71.2-1.10.5
Condit. Reinf. active-inactive response ratio1.51.62.4-1.60.9
Condit. Reinf. active responses0.20.20.30.4-0.6
Condit. Reinf. inactive responses5.16.78.02.8-2.3
Incentive salience index mean0.40.50.80.4-0.9
Condit. Reinf. lever presses2.13.13.31.7-1.8
Condit. Reinf. active minus inactive responses0.10.20.2-0.40.4
Condit. Reinf. active-inactive response ratio0.40.61.1-0.31.0
Condit. Reinf. active responses0.00.00.0-0.10.0
Condit. Reinf. inactive responses0.10.10.2-0.4-0.2
Condit. Reinf. lever presses0.30.50.6-0.80.6
Condit. Reinf. lever reinforcers received0.10.20.2-0.40.4
Conditioned reinforcement - actives0.00.10.10.0-0.3
Conditioned reinforcement - inactives0.10.30.6-0.80.1
Conditioned locomotion0.10.10.10.4-0.4
Patch foraging indifference point 0 sec0.20.71.2-1.10.4
Patch foraging indifference point AUC0.51.11.21.1-1.0
Delay disc. indifference point, 0s delay1.11.31.31.1-1.2
Delay disc. indifference point, 16s delay0.50.70.8-0.80.9
Delay disc. indifference point, 2s delay0.20.20.3-0.20.5
Delay disc. indifference point, 24s delay0.00.00.00.0-0.0
Delay disc. indifference point, 4s delay0.10.10.1-0.3-0.2
Delay disc. indifference point, 8s delay0.50.91.2-1.10.8
Indifference point function ln k0.51.41.6-1.31.1
Indifference point function log k0.51.41.6-1.31.1
Patch foraging total patch changes 0 sec0.41.01.6-1.30.6
Patch foraging total patch changes 12 sec0.60.81.50.4-1.2
Patch foraging total patch changes 18 sec0.92.02.71.2-1.6
Patch foraging total patch changes 24 sec0.41.42.10.8-1.5
Patch foraging total patch changes 6 sec0.10.20.40.3-0.6
Patch foraging time to switch 0 sec0.00.00.10.0-0.3
Patch foraging water rate 0 sec0.00.00.10.30.1
Patch foraging water rate 12 sec0.20.91.11.0-0.9
Patch foraging water rate 18 sec1.84.05.52.3-1.6
Patch foraging water rate 24 sec0.00.10.10.3-0.2
Patch foraging water rate 6 sec4.05.96.52.5-2.3
Seeking ratio, delayed vs. immediate footshock3.85.56.2-2.52.2
Distance traveled before self-admin1.73.64.3-1.72.1
Distance traveled after self-admin0.20.30.60.00.8
Extensor digitorum longus weight0.10.30.30.60.4
Bone: elastic displacement0.00.00.00.0-0.1
Bone: elastic work0.00.00.10.2-0.0
Bone: endosteal estimation0.10.10.2-0.40.3
Bone: endosteal perimeter0.10.20.4-0.60.2
Epididymis fat weight0.21.11.3-1.11.0
Delta time in closed arm before/after self-admin0.40.40.5-0.70.6
Delta time in open arm before/after self-admin0.50.60.70.8-0.7
Diff in mean of infusions in LGA sessions0.10.20.3-0.5-0.2
Delay discount exponential model param0.10.10.20.4-0.3
Extinction: sum of active levers before priming3.45.25.5-2.32.2
Active lever presses in extinction session 60.10.10.1-0.10.3
Bone: final force1.32.13.11.7-1.0
Bone: final moment0.81.32.01.4-0.8
Food consumed during 24 hour testing period3.57.17.42.6-2.7
Glucose0.71.11.21.1-1.0
Heart weight0.60.91.4-1.20.7
Delay discount hyperbolic model param0.10.10.20.4-0.2
Intermittent access intake day 1-15 change1.16.17.02.3-2.6
Intermittent access intake escalation0.84.55.22.0-2.3
Intermittent access intake escalation 22.23.64.91.5-2.2
Intermitt. access day 1 inactive lever presses0.00.10.2-0.4-0.1
Intermitt. access day 15 inactive lever presses0.31.42.1-1.50.8
Intermitt. access escalation Index0.00.10.2-0.40.3
Intermittent access day 1 total infusions0.92.82.9-1.71.7
Intermittent access day 15 total infusions0.00.00.1-0.20.2
Intermittent access terminal intake (last 3 days)0.10.20.3-0.60.3
Intermittent access total infusions0.10.10.1-0.30.3
Intermittent access day 1 locomotion0.10.10.3-0.10.5
Intermittent access day 15 total locomotion0.10.40.7-0.20.8
Intermittent access total locomotion0.20.20.4-0.20.6
Intermittent access standard deviation0.31.72.11.1-1.5
Left kidney weight0.43.54.12.0-1.7
Right kidney weight0.10.70.70.8-0.9
Cocaine induced anxiety0.20.61.1-1.10.2
Post-drug Anxiety0.30.40.7-0.80.4
Baseline Anxiety0.10.20.40.60.0
Tail length0.95.05.52.4-2.1
Length with tail0.20.71.01.0-0.7
Length without tail0.10.81.0-0.81.0
Times rat made contact with spout0.20.30.50.7-0.3
Lifetime Intake0.00.00.1-0.20.0
Liver weight, left0.10.20.30.4-0.6
Liver weight, right0.00.00.00.10.1
Locomotor activity0.10.10.2-0.10.4
Locomotor testing distance0.10.10.1-0.40.3
Locomotor testing rearing0.20.81.40.6-1.2
Locomotion in novel chamber0.30.40.6-0.80.6
Locomotion in novel chamber post-restriction0.20.70.90.9-0.7
Fecal boli incidents, locomotor time 10.51.21.60.9-1.3
Change in fecal boli incidents, locomotor task0.10.10.2-0.1-0.4
Time >=10cm from walls, locomotor time 10.20.20.40.6-0.3
Bouts of movement, locomotor time 10.60.80.90.8-1.0
Total resting periods, locomotor time 10.30.40.50.5-0.7
Rest time, locomotor task time 10.20.40.50.7-0.6
Distance moved, locomotor task time 10.30.80.9-0.90.8
Vertical activity count, locomotor time 10.10.40.40.6-0.6
Time >=10cm from walls, locomotor time 20.20.61.1-0.41.0
Bouts of movement, locomotor time 20.00.00.0-0.20.1
Total resting periods, locomotor time 20.00.00.10.0-0.2
Rest time, locomotor task time 20.20.30.50.4-0.7
Distance moved, locomotor task time 22.12.83.4-1.51.8
Vertical activity count, locomotor time 20.00.10.10.3-0.3
Light reinforcement 16.228.228.45.3-5.3
Light reinforcement 26.915.717.24.1-3.8
Bone: marrow area0.10.20.2-0.40.4
Bone: maximum diameter0.10.20.3-0.50.4
Bone: maximum force0.10.30.50.7-0.3
Bone: maximum moment0.00.10.20.4-0.0
Mean time between licks in bursts0.00.10.1-0.2-0.3
Mean num. licks in bursts0.00.10.3-0.00.5
Cd content in liver3.64.05.5-2.31.6
Co content in liver1.72.02.6-1.61.1
Cu content in liver0.00.00.0-0.10.2
Fe content in liver1.92.34.12.0-0.8
K content in liver1.11.11.6-0.71.3
Mg content in liver0.70.80.9-0.80.9
Mn content in liver1.21.41.9-1.40.9
Na content in liver0.20.20.30.50.3
Rb content in liver0.80.91.01.0-0.9
Se content in liver1.82.13.31.8-0.9
Sr content in liver0.60.50.5-0.70.7
Zn content in liver2.42.82.8-1.71.7
Bone: minimum diameter0.71.41.71.3-1.0
Time in familiar zone, hab. session 10.60.70.80.7-0.9
Time in novel zone, hab. session 10.60.71.1-0.61.0
Total zone transitions, hab. session 10.10.20.2-0.50.4
Total locomotion distance, hab. session 10.60.80.9-1.00.8
Locomotion velocity, hab. session 10.40.60.8-0.90.7
Time in familiar zone, hab. session 21.92.13.01.2-1.7
Time in novel zone, hab. session 24.65.06.1-2.02.5
Total zone transitions, hab. session 20.10.10.20.1-0.4
Total locomotion distance, hab. session 20.00.00.1-0.30.1
Locomotion velocity, hab. session 20.00.00.00.0-0.1
Novel to familiar place preference ratio1.31.72.0-1.21.4
Novelty place preference1.11.51.8-1.11.3
Time in novel zone, NPP test1.11.31.8-0.91.3
Total zone transitions, NPP test0.00.00.0-0.1-0.2
Total locomotion distance, NPP test0.00.10.1-0.20.3
Locomotion velocity, NPP test0.00.00.0-0.10.0
Intraocular pressure4.26.88.0-2.82.4
Delta distance traveled before/after self-admin2.62.93.61.9-1.5
Delta ambulatory time before/after self-admin2.84.95.42.3-2.1
Parametrial fat weight0.10.10.1-0.3-0.4
Pavlov. Cond. lever latency0.00.10.1-0.30.0
Pavlov. Cond. magazine entry latency0.00.00.1-0.10.3
Pavlov. Cond. change in total contacts1.01.01.51.2-0.7
Pavlov. Cond. index score0.10.10.2-0.20.4
Pavlov. Cond. latency score0.10.10.1-0.30.3
Pavlov. Cond. lever contacts0.00.00.10.20.1
Pavlov. Cond. magazine entry number0.10.10.20.1-0.5
Pavlov. Cond. intertrial magazine entries0.00.00.0-0.1-0.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.40.6
Pavlov. Cond. response bias0.10.10.10.40.3
Pavlov. Cond. lever latency0.50.60.8-0.70.9
Pavlov. Cond. magazine entry latency0.10.10.10.1-0.4
Pavlov. Cond. change in total contacts0.00.10.10.2-0.3
Pavlov. Cond. index score0.10.10.10.2-0.4
Pavlov. Cond. latency score0.00.10.10.2-0.3
Pavlov. Cond. lever contacts0.91.31.51.0-1.2
Pavlov. Cond. magazine entry number0.00.00.00.00.0
Pavlov. Cond. intertrial magazine entries0.51.11.21.0-1.1
Pavlov. Cond. lever-magazine prob. diff.0.00.10.10.2-0.3
Pavlov. Cond. response bias0.30.50.50.6-0.7
Time in closed arm before self-admin2.95.15.82.4-2.1
Time in closed arm after self-admin1.41.61.91.4-1.2
Time in open arm before self-admin1.82.22.8-1.71.3
Time in open arm after self-admin1.31.41.5-1.21.2
Bone: periosteal estimation0.00.10.10.4-0.3
Bone: periosteal perimeter0.00.00.0-0.2-0.1
Bone: post-yield work0.00.10.1-0.30.2
Progressive ratio test 1 active lever presses0.10.10.2-0.10.5
Progressive ratio test 1 breakpoint0.10.10.2-0.10.5
Progressive ratio test 1 inactive lever presses0.10.10.2-0.50.3
Progressive ratio test 2 active lever presses0.20.20.3-0.40.5
Progressive ratio test 2 breakpoint0.30.30.4-0.50.6
Progressive ratio test 2 inactive lever presses0.62.02.5-1.61.2
Incentive Sensitization - Responses0.10.10.2-0.50.2
Incentive Sensitization - Breakpoint0.00.10.2-0.40.1
Sum of active levers in priming session hrs 5-60.40.40.4-0.70.5
Progressive ratio0.10.30.50.7-0.5
Food seeking constrained by brief footshock2.73.43.61.8-1.9
Seeking ratio, punishment vs. effort0.51.21.21.1-1.1
Retroperitoneal fat weight0.31.52.6-1.60.6
Reaction time number correct0.20.80.9-0.90.9
Reaction time mean minus median0.21.52.2-0.81.5
Reaction time mean minus median AUC0.32.12.8-1.21.7
Reaction time num false alarms3.96.58.5-2.92.1
Reaction time num false alarms AUC2.35.27.0-2.61.9
Reaction time trials correct on left0.20.80.9-0.90.9
Reaction time trials on left0.31.01.1-1.01.0
Reaction time mean2.96.47.6-2.32.8
Reaction time mean AUC2.76.67.6-2.42.7
Median of all reaction times3.86.06.8-2.32.6
Reaction time omissions2.33.73.8-1.91.9
Reaction time false alarm rate1.52.13.0-1.71.1
Reaction time premature initiation rate3.96.17.72.1-2.8
Reaction time premature initiations0.92.73.81.3-1.9
Std. dev. reaction times0.82.73.4-1.41.8
Reaction time trials completed0.31.01.1-1.01.0
Reaction time trials AUC0.31.11.2-1.11.0
Run reversals in cocaine runway, females0.70.81.1-0.71.1
Run reversals in cocaine runway, males0.20.30.4-0.40.6
Latency to leave start box in cocaine runway0.71.01.2-1.10.9
Latency to leave start box in cocaine runway, F1.51.92.4-1.21.6
Latency to leave start box in cocaine runway, M0.30.20.5-0.2-0.7
Std. dev. time between licks in bursts0.30.50.60.6-0.8
Total sessions with >9 infusions0.00.00.1-0.10.2
Short access day 1 total inactive lever presses0.00.00.00.10.0
Short access day 10 total inactive lever presses0.10.50.80.4-0.9
Short access day 1 total infusions0.40.80.8-0.90.9
Short access day 10 total infusions0.00.00.0-0.2-0.0
Short access total infusions0.10.10.1-0.40.2
Short access day 1 locomotion1.72.83.0-1.61.7
Short access day 10 total locomotion0.00.10.1-0.40.3
Short access total locomotion0.50.70.8-0.90.8
One hour access (0.3 mA shock)0.60.71.3-1.10.3
Compulsive drug intake0.00.10.1-0.1-0.3
One hour access (shock baseline)0.20.50.8-0.90.5
Social response proportion0.30.30.5-0.40.7
Social responses0.20.30.6-0.70.2
Social time0.40.60.70.9-0.7
Soleus weight0.00.10.1-0.1-0.4
Bone: stiffness0.10.10.30.50.0
Tibialis anterior weight0.51.62.0-1.11.4
Time to tail flick, vehicle, before self-admin0.00.00.1-0.3-0.0
Time to tail flick, vehicle, after self-admin0.30.60.90.5-1.0
Time to tail flick, test, before self-admin1.41.71.8-1.31.2
Time to tail flick, test, after self-admin1.11.11.61.3-0.8
Delta time to tail flick, vehicle, before/after SA0.30.30.40.5-0.7
Delta time to tail flick, test, before/after SA1.82.23.41.8-1.0
Tibia length0.10.30.50.40.7
Ambulatory time before self-admin1.54.65.2-2.02.3
Ambulatory time after self-admin0.10.20.40.70.0
Bone: tissue strength0.10.10.1-0.20.4
Total heroin consumption0.50.60.8-0.90.6
Bone: trabecular number1.93.74.42.1-1.7
Bone: trabecular spacing2.23.24.0-2.01.6
Bone: trabecular thickness3.44.76.62.6-1.7
Bone: trabecular tissue density0.81.41.7-1.11.3
Water consumed over 24 hours1.32.62.81.7-1.5
Number of responses in last shaping day1.52.02.9-1.71.1