LOC120098514

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	alternative polyA	XR_005496770.2	0.09	0.07	6.8e-03	0.01	0.01	0	0	1.4e-02	6.6e-02	1.8e-01	7.9e-02
2	RMTg	alternative polyA	XR_005496770.2	0.26	0.19	4.9e-04	0.13	0.1	0.09	0.1	2.9e-04	1.5e-03	2.7e-03	1.5e-03
3	RMTg	gene expression	LOC120098514	0.22	0.15	9.5e-05	0.15	0.15	0.14	0.16	1.1e-04	9.0e-05	1.3e-04	6.7e-05
4	pVTA	gene expression	LOC120098514	0.05	0.04	1.0e-04	0.04	0.05	0.04	0.05	1.9e-04	6.5e-05	2.5e-04	8.6e-05
5	Brain	gene expression	LOC120098514	0.02	0.02	8.6e-03	0.01	0.02	0.01	0.01	5.5e-02	7.5e-03	8.1e-02	1.4e-02
6	RMTg	alternative polyA	XR_005496768.2	0.19	0.13	8.1e-04	0.09	0.1	0.06	0.09	2.4e-03	1.6e-03	8.2e-03	2.0e-03
7	NAcc	gene expression	LOC120098514	0.06	0.05	1.9e-04	0.01	0.02	0.01	0.03	2.9e-02	4.5e-04	3.2e-03	6.0e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	0.8	1.3	5.4	2.3	-0.9	0.8	1.1	0.8	0.5	-0.5
Area under the delay curve	0.4	0.5	0.9	-0.9	0.8	-0.7	-0.9	-0.7	-0.5	-0.1
BMI with tail	0.6	2.2	9.2	-3.0	1.4	-1.3	-1.4	-0.6	-0.2	0.4
BMI without tail	0.4	1.1	1.5	-1.0	1.2	-1.2	-1.2	-1.1	-0.9	-0.5
Body weight	0.2	0.8	3.1	-1.8	0.2	-0.1	0.0	0.5	0.9	1.1
Weight adjusted by age	0.9	1.4	4.9	-2.2	-0.7	0.6	0.5	0.8	0.8	1.6
Bone surface	0.2	0.4	2.0	1.4	0.0	-0.0	0.2	-0.1	-0.2	-0.7
Bone volume	0.5	0.9	4.6	2.2	-0.1	0.1	0.4	0.0	-0.2	-1.2
Breakpoint value in progressive ratio session	0.6	0.7	1.6	1.3	-0.7	0.8	0.9	0.8	0.8	0.5
Number of licking bursts	0.1	0.2	0.4	0.6	-0.6	0.5	0.6	0.4	0.3	-0.1
Context. condit. distance diff. score	0.4	0.5	3.1	-1.8	0.0	-0.0	-0.3	-0.0	-0.0	0.7
Locomotion velocity, session 1	0.1	0.1	0.2	-0.1	0.4	-0.4	-0.4	-0.4	-0.4	-0.1
Locomotion distance, session 1	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.2	-0.1	-0.1	0.0
Locomotion velocity, session 2	0.0	0.0	0.1	-0.0	0.1	-0.1	-0.2	-0.2	-0.3	0.0
Locomotion distance, session 2	0.3	0.5	1.0	-0.3	-0.5	0.6	0.5	0.7	0.9	1.0
Locomotion velocity, session 3	1.1	1.3	3.9	-2.0	1.0	-1.1	-1.1	-1.0	-0.9	0.2
Locomotion distance, session 3	3.0	3.2	4.1	-1.0	1.9	-2.0	-1.9	-1.9	-2.0	-1.6
Stereotopy head waving bouts, day 3	1.2	1.5	2.1	-1.4	1.4	-1.3	-1.4	-1.2	-1.0	0.1
Stereotopy head waving duration, day 3	0.7	0.8	2.1	-1.5	0.8	-0.8	-1.0	-0.6	-0.4	0.9
Locomotion velocity, session 7	0.2	0.3	0.5	-0.5	-0.6	0.5	0.4	0.5	0.4	0.7
Locomotion distance, session 7	2.4	3.0	4.1	1.4	-2.0	2.0	1.9	1.9	1.7	0.8
Stereotopy head waving bouts, day 7	6.8	7.7	10.2	-2.1	3.1	-3.1	-3.2	-3.1	-2.9	-1.4
Stereotopy head waving duration, day 7	6.7	8.0	10.5	-1.1	3.1	-3.2	-3.1	-3.2	-3.2	-2.0
Locomotion velocity, session 8	2.1	2.5	3.3	-0.5	-1.7	1.7	1.5	1.8	1.8	1.7
Locomotion distance, session 8	0.6	0.8	1.4	-1.2	-0.7	0.7	0.5	0.9	1.0	1.1
Degree of sensitization distance	7.8	8.0	10.5	1.4	-3.1	3.2	3.0	3.1	3.1	2.4
Degree of sensitization stereotypy	6.8	7.3	9.6	-1.9	3.0	-3.1	-3.1	-3.0	-2.9	-1.6
Conditioned locomotion	0.5	0.5	0.8	0.7	-0.8	0.8	0.9	0.8	0.7	0.2
Cocaine response after cond. corrected	1.0	1.2	2.1	-0.8	-1.0	1.0	0.8	1.2	1.4	1.4
Cocaine response after cond. not corrected	0.8	1.0	1.7	-0.9	-0.8	0.9	0.7	1.0	1.3	1.2
Cocaine response before conditioning	1.0	1.2	2.5	0.5	1.2	-1.1	-1.0	-1.1	-1.0	-1.6
Saline control response	4.9	6.6	8.5	2.3	-2.8	2.8	2.9	2.7	2.6	1.7
Bone: connectivity density	1.3	2.0	6.2	2.5	-1.2	1.2	1.5	1.3	1.1	-0.0
Bone: cortical apparent density	1.8	2.4	3.2	0.3	1.6	-1.7	-1.5	-1.6	-1.8	-1.7
Bone: cortical area	0.1	0.2	0.7	0.6	0.1	-0.1	0.1	0.0	0.1	-0.8
Bone: cortical porosity	0.1	0.2	0.4	-0.6	0.4	-0.4	-0.4	-0.4	-0.3	0.0
Bone: cortical porosity	0.6	0.6	0.9	-0.3	0.9	-0.9	-0.9	-1.0	-0.9	-0.6
Bone: cortical thickness	0.2	0.3	0.8	0.5	0.5	-0.5	-0.3	-0.3	-0.3	-0.9
Bone: cortical thickness	0.7	0.8	1.2	-0.1	-1.0	0.9	0.9	1.1	1.1	0.9
Bone: cortical tissue density	1.8	2.4	3.2	0.2	1.6	-1.7	-1.6	-1.7	-1.8	-1.7
Condit. Reinf. active minus inactive responses	8.7	9.7	13.2	-1.0	3.6	-3.6	-3.4	-3.3	-3.2	-2.8
Condit. Reinf. active-inactive response ratio	2.0	2.2	3.0	-1.3	1.7	-1.7	-1.7	-1.5	-1.3	-0.8
Condit. Reinf. active responses	8.4	10.4	13.0	-0.2	3.6	-3.6	-3.4	-3.5	-3.5	-3.4
Condit. Reinf. inactive responses	2.3	2.9	5.9	1.9	1.4	-1.4	-1.1	-1.5	-1.7	-2.4
Incentive salience index mean	9.7	12.0	15.7	0.3	3.8	-3.8	-3.4	-3.7	-3.7	-4.0
Condit. Reinf. lever presses	6.2	8.7	16.2	1.3	2.9	-2.9	-2.5	-3.1	-3.2	-4.0
Condit. Reinf. active minus inactive responses	0.1	0.2	0.4	-0.3	0.6	-0.4	-0.5	-0.3	-0.0	-0.5
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	-0.3	0.1	0.1	-0.0	0.3	0.6	0.4
Condit. Reinf. active responses	0.2	0.2	0.4	-0.6	0.6	-0.4	-0.5	-0.3	-0.0	-0.5
Condit. Reinf. inactive responses	0.1	0.1	0.9	-0.9	-0.1	0.1	-0.0	0.1	0.2	0.1
Condit. Reinf. lever presses	0.2	0.3	1.0	-1.0	0.6	-0.5	-0.6	-0.3	-0.1	-0.2
Condit. Reinf. lever reinforcers received	0.4	0.5	1.1	-1.1	0.9	-0.7	-0.8	-0.6	-0.3	-0.5
Conditioned reinforcement - actives	1.2	2.0	3.1	0.2	-1.5	1.5	1.4	1.5	1.5	1.7
Conditioned reinforcement - inactives	0.1	0.2	0.9	-0.9	-0.0	-0.0	-0.2	-0.1	-0.1	0.7
Conditioned locomotion	0.3	0.4	1.0	0.3	-1.0	0.8	0.6	0.3	0.0	0.9
Patch foraging indifference point 0 sec	0.3	0.5	2.2	-1.5	-0.1	0.1	-0.2	0.2	0.3	1.1
Patch foraging indifference point AUC	0.6	0.9	3.0	1.7	-0.7	0.8	0.9	0.7	0.7	-0.6
Delay disc. indifference point, 0s delay	0.4	0.4	0.6	0.6	-0.7	0.8	0.7	0.6	0.6	0.2
Delay disc. indifference point, 16s delay	0.3	0.3	1.4	-1.2	0.4	-0.3	-0.4	0.0	0.1	0.6
Delay disc. indifference point, 2s delay	0.2	0.2	0.9	-0.9	0.1	-0.1	-0.5	-0.4	-0.3	0.1
Delay disc. indifference point, 24s delay	0.6	0.6	1.0	-0.4	1.0	-0.9	-0.8	-0.8	-0.8	-0.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.0	-0.3	0.3	0.0	0.1	0.2	0.5
Delay disc. indifference point, 8s delay	0.7	0.8	2.4	-1.6	0.8	-0.7	-1.0	-0.7	-0.4	-0.2
Indifference point function ln k	1.0	1.7	2.6	-1.6	1.4	-1.4	-1.5	-1.2	-1.2	-0.1
Indifference point function log k	1.0	1.7	2.6	-1.6	1.4	-1.4	-1.5	-1.2	-1.2	-0.1
Patch foraging total patch changes 0 sec	0.4	0.7	3.0	-1.7	-0.2	0.2	-0.0	0.3	0.5	1.3
Patch foraging total patch changes 12 sec	0.2	0.3	1.0	1.0	-0.4	0.5	0.5	0.4	0.5	-0.3
Patch foraging total patch changes 18 sec	1.1	1.6	3.4	1.8	-1.4	1.3	1.4	1.2	1.1	0.2
Patch foraging total patch changes 24 sec	0.2	0.4	0.6	0.6	-0.8	0.7	0.7	0.5	0.5	0.2
Patch foraging total patch changes 6 sec	0.3	0.5	0.8	0.1	-0.7	0.7	0.7	0.8	0.9	0.6
Patch foraging time to switch 0 sec	0.4	0.8	1.1	-0.3	1.0	-1.0	-1.0	-0.9	-1.0	-0.6
Patch foraging water rate 0 sec	1.2	2.5	3.2	0.5	-1.8	1.8	1.7	1.7	1.7	1.5
Patch foraging water rate 12 sec	0.1	0.2	0.9	0.9	-0.2	0.1	0.3	-0.1	-0.3	-0.2
Patch foraging water rate 18 sec	0.4	0.7	2.0	1.2	0.5	-0.4	-0.2	-0.6	-0.7	-1.4
Patch foraging water rate 24 sec	0.4	0.5	0.9	0.3	0.8	-0.7	-0.6	-0.7	-0.8	-1.0
Patch foraging water rate 6 sec	1.8	2.6	5.7	2.4	-1.5	1.5	1.9	1.5	1.3	-0.0
Seeking ratio, delayed vs. immediate footshock	1.2	1.5	6.6	-2.6	1.0	-0.9	-1.2	-0.7	-0.4	0.5
Distance traveled before self-admin	2.4	3.2	4.4	-2.0	2.0	-1.9	-2.1	-1.8	-1.6	-1.0
Distance traveled after self-admin	0.9	1.1	1.8	-0.4	1.1	-1.2	-1.2	-1.3	-1.4	-0.5
Extensor digitorum longus weight	0.1	0.3	0.5	0.5	-0.5	0.5	0.6	0.6	0.7	-0.2
Bone: elastic displacement	0.5	0.6	0.8	0.7	-0.9	0.8	0.9	0.8	0.7	0.8
Bone: elastic work	0.3	0.4	0.5	0.5	-0.6	0.7	0.7	0.7	0.6	0.4
Bone: endosteal estimation	0.2	0.5	0.8	-0.1	-0.9	0.9	0.8	0.7	0.7	0.6
Bone: endosteal perimeter	0.3	0.6	0.8	-0.4	-0.9	0.9	0.8	0.9	0.9	0.7
Epididymis fat weight	0.2	0.6	1.6	-1.3	0.7	-0.8	-0.9	-0.6	-0.5	0.1
Delta time in closed arm before/after self-admin	0.4	0.3	0.6	-0.7	0.8	-0.7	-0.7	-0.4	-0.2	-0.4
Delta time in open arm before/after self-admin	1.6	1.6	2.2	1.1	-1.4	1.4	1.5	1.3	1.1	0.9
Diff in mean of infusions in LGA sessions	1.6	2.0	2.5	0.9	-1.5	1.5	1.5	1.6	1.6	1.2
Delay discount exponential model param	0.6	0.6	1.0	0.8	-0.9	0.8	1.0	0.8	0.7	0.3
Extinction: sum of active levers before priming	1.0	1.1	3.2	-1.8	0.9	-1.0	-1.1	-0.9	-0.8	0.0
Active lever presses in extinction session 6	0.7	0.7	0.9	0.1	0.9	-0.9	-1.0	-1.0	-0.9	-0.9
Bone: final force	0.2	0.3	1.0	1.0	0.1	-0.0	0.1	-0.2	-0.2	-1.0
Bone: final moment	0.1	0.2	0.7	0.7	0.2	-0.1	-0.0	-0.2	-0.2	-0.8
Food consumed during 24 hour testing period	1.6	2.2	8.3	2.9	-1.1	1.1	1.6	1.1	0.8	-0.5
Glucose	0.9	1.4	1.8	0.3	-1.3	1.3	1.3	1.3	1.3	0.9
Heart weight	0.2	0.3	1.0	-1.0	0.4	-0.3	-0.4	-0.1	0.1	0.8
Delay discount hyperbolic model param	0.6	0.7	1.1	0.8	-0.9	0.8	1.1	0.9	0.8	0.4
Intermittent access intake day 1-15 change	0.6	1.2	4.5	2.1	-0.9	0.9	1.1	0.7	0.6	-0.6
Intermittent access intake escalation	0.4	0.9	3.3	1.8	-0.8	0.8	0.9	0.6	0.4	-0.5
Intermittent access intake escalation 2	1.0	1.1	2.2	1.5	-0.9	1.0	1.1	1.1	1.1	-0.3
Intermitt. access day 1 inactive lever presses	0.7	2.8	4.3	-0.3	1.7	-1.8	-1.6	-1.9	-2.1	-1.7
Intermitt. access day 15 inactive lever presses	1.4	2.8	3.9	-0.9	1.7	-1.8	-1.9	-1.9	-2.0	-1.0
Intermitt. access escalation Index	1.5	2.1	2.6	-0.5	1.6	-1.6	-1.5	-1.6	-1.6	-1.5
Intermittent access day 1 total infusions	0.3	0.5	1.7	-1.3	-0.2	-0.0	-0.4	-0.4	-0.5	1.0
Intermittent access day 15 total infusions	0.5	0.7	1.5	-0.1	-1.2	1.1	0.8	0.6	0.5	1.0
Intermittent access terminal intake (last 3 days)	0.6	0.8	1.4	-0.4	-1.2	1.1	0.7	0.7	0.7	1.2
Intermittent access total infusions	0.3	0.4	0.9	-0.0	-0.9	0.7	0.5	0.3	0.1	1.0
Intermittent access day 1 locomotion	0.2	0.3	1.1	-0.1	0.1	-0.3	-0.3	-0.7	-1.1	0.0
Intermittent access day 15 total locomotion	0.2	0.4	1.2	-0.4	-0.8	0.5	0.4	0.2	-0.2	1.1
Intermittent access total locomotion	0.2	0.3	1.0	-0.3	-0.6	0.3	0.2	-0.1	-0.5	1.0
Intermittent access standard deviation	0.1	0.3	1.0	1.0	-0.2	0.1	0.2	-0.2	-0.3	-1.0
Left kidney weight	0.3	1.6	4.7	2.2	-0.9	1.0	1.4	1.2	1.2	-0.3
Right kidney weight	0.0	0.2	0.5	0.5	-0.0	0.1	0.4	0.5	0.7	0.0
Cocaine induced anxiety	0.2	0.3	1.0	-1.0	-0.2	0.3	-0.1	0.3	0.5	0.6
Post-drug Anxiety	0.1	0.1	0.5	-0.7	0.3	-0.2	-0.5	-0.2	0.0	-0.0
Baseline Anxiety	0.5	0.6	0.9	0.7	0.8	-0.8	-0.5	-0.7	-0.8	-0.9
Tail length	0.2	0.9	3.6	1.9	-1.0	0.8	1.0	0.4	0.1	-0.1
Length with tail	0.2	0.7	1.0	0.6	-0.9	0.8	1.0	0.9	0.8	0.8
Length without tail	0.2	0.7	1.8	-0.9	-0.3	0.4	0.5	0.8	1.0	1.3
Times rat made contact with spout	0.1	0.1	0.2	0.2	0.2	-0.2	-0.1	-0.3	-0.4	-0.4
Lifetime Intake	0.5	0.6	1.4	0.1	-1.2	1.0	0.7	0.5	0.3	1.1
Liver weight, left	0.1	0.1	0.2	0.0	-0.2	0.3	0.2	0.3	0.4	0.4
Liver weight, right	0.1	0.1	0.3	-0.6	0.4	-0.3	-0.2	-0.1	0.1	0.0
Locomotor activity	1.0	1.6	2.8	-0.8	-1.2	1.3	1.1	1.4	1.7	1.1
Locomotor testing distance	1.2	2.2	3.3	-0.6	-1.6	1.6	1.3	1.6	1.8	1.4
Locomotor testing rearing	1.0	2.0	3.4	0.5	-1.4	1.6	1.5	1.7	1.8	0.8
Locomotion in novel chamber	0.5	0.7	1.3	-1.2	0.5	-0.7	-0.9	-1.0	-1.0	-0.1
Locomotion in novel chamber post-restriction	0.5	0.8	2.3	0.9	0.7	-0.7	-0.5	-0.7	-0.8	-1.5
Fecal boli incidents, locomotor time 1	0.9	1.3	1.6	1.2	-1.1	1.2	1.3	1.2	1.2	0.7
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.0	0.7	-0.7	-0.5	-0.5	-0.5	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.4	-0.1	0.3	-0.3	-0.3	-0.4	-0.3	-0.6
Bouts of movement, locomotor time 1	0.3	0.3	1.9	1.4	-0.1	0.2	0.5	0.4	0.2	-0.2
Total resting periods, locomotor time 1	0.2	0.2	1.3	1.1	0.1	0.0	0.3	0.3	0.1	-0.3
Rest time, locomotor task time 1	0.6	0.7	1.2	1.1	-0.6	0.8	1.0	1.0	1.0	0.0
Distance moved, locomotor task time 1	0.2	0.3	0.6	-0.7	0.3	-0.5	-0.5	-0.6	-0.8	-0.1
Vertical activity count, locomotor time 1	0.0	0.1	0.2	0.5	-0.2	0.0	0.1	-0.2	-0.4	-0.0
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.7	-0.8	-0.3	0.2	-0.0	-0.0	0.0	0.5
Bouts of movement, locomotor time 2	0.2	0.3	0.6	0.1	0.4	-0.4	-0.6	-0.5	-0.6	-0.7
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.4	0.1	-0.0	-0.2	-0.1	-0.2	-0.6
Rest time, locomotor task time 2	1.8	2.2	3.2	1.6	-1.3	1.5	1.6	1.7	1.8	0.7
Distance moved, locomotor task time 2	1.1	1.4	4.7	-2.2	0.7	-0.9	-1.1	-1.1	-1.0	0.1
Vertical activity count, locomotor time 2	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.0	-0.2	-0.2	0.3
Light reinforcement 1	3.0	7.3	27.8	5.3	-2.2	2.2	2.8	1.8	1.5	-0.7
Light reinforcement 2	3.4	5.2	17.6	4.2	-2.0	2.0	2.4	1.7	1.4	-0.3
Bone: marrow area	0.2	0.5	0.8	-0.2	-0.9	0.9	0.7	0.7	0.7	0.6
Bone: maximum diameter	0.2	0.3	0.6	-0.8	0.6	-0.6	-0.6	-0.4	-0.2	-0.5
Bone: maximum force	0.1	0.3	0.5	0.7	-0.4	0.5	0.6	0.5	0.5	-0.1
Bone: maximum moment	0.1	0.1	0.2	0.4	-0.3	0.4	0.4	0.4	0.4	-0.0
Mean time between licks in bursts	1.7	4.3	5.1	-0.9	2.3	-2.2	-2.2	-2.3	-2.2	-2.0
Mean num. licks in bursts	0.5	0.7	1.0	-0.4	1.0	-1.0	-1.0	-0.9	-0.9	-0.6
Cd content in liver	0.1	0.1	0.3	-0.6	0.2	-0.2	-0.3	0.0	0.1	0.1
Co content in liver	2.5	3.0	3.9	-1.3	2.0	-1.9	-2.0	-1.8	-1.8	-1.2
Cu content in liver	0.4	0.5	0.6	-0.3	0.7	-0.7	-0.7	-0.8	-0.8	-0.6
Fe content in liver	1.5	1.8	3.4	0.8	1.3	-1.3	-1.1	-1.4	-1.5	-1.8
K content in liver	1.0	0.9	1.3	-1.1	1.1	-1.0	-1.2	-1.0	-0.9	-0.4
Mg content in liver	0.5	0.5	1.4	-1.2	0.6	-0.6	-0.8	-0.6	-0.4	0.2
Mn content in liver	0.5	0.6	0.8	-0.4	-0.9	0.9	0.7	0.8	0.7	0.9
Na content in liver	0.2	0.3	0.5	-0.2	0.4	-0.4	-0.5	-0.7	-0.7	-0.5
Rb content in liver	0.0	0.0	0.1	0.4	0.1	-0.1	-0.1	-0.1	-0.0	-0.2
Se content in liver	1.1	1.4	4.4	0.8	0.8	-0.8	-0.6	-1.1	-1.2	-2.1
Sr content in liver	0.5	0.4	0.6	-0.8	0.7	-0.7	-0.7	-0.7	-0.5	-0.4
Zn content in liver	0.4	0.5	2.4	-1.5	0.3	-0.3	-0.5	-0.0	0.2	0.7
Bone: minimum diameter	0.4	0.7	2.5	1.6	-0.4	0.5	0.7	0.5	0.4	-0.9
Time in familiar zone, hab. session 1	2.9	2.8	4.5	0.6	1.5	-1.6	-1.4	-1.8	-2.0	-2.1
Time in novel zone, hab. session 1	1.4	1.4	2.1	-0.3	-1.2	1.2	1.0	1.3	1.4	1.4
Total zone transitions, hab. session 1	0.2	0.3	0.9	-0.6	-0.4	0.4	0.3	0.4	0.6	0.9
Total locomotion distance, hab. session 1	0.8	1.1	2.2	-0.4	-1.0	1.0	0.9	1.1	1.2	1.5
Locomotion velocity, hab. session 1	0.9	1.2	2.5	-0.4	-1.0	1.0	0.9	1.2	1.3	1.6
Time in familiar zone, hab. session 2	0.4	0.4	2.1	1.4	-0.2	0.2	0.3	-0.0	-0.2	-0.7
Time in novel zone, hab. session 2	0.6	0.6	3.1	-1.7	-0.0	0.0	-0.2	0.2	0.3	1.0
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.2	0.3	-0.3	-0.3	-0.3	-0.3	0.1
Total locomotion distance, hab. session 2	0.9	1.1	1.5	-0.0	-1.1	1.1	1.0	1.2	1.2	1.2
Locomotion velocity, hab. session 2	1.1	1.4	2.0	0.2	-1.2	1.3	1.2	1.3	1.4	1.3
Novel to familiar place preference ratio	0.3	0.3	1.0	-1.0	0.3	-0.4	-0.5	-0.3	-0.4	0.4
Novelty place preference	0.2	0.2	0.6	-0.7	-0.2	0.2	0.0	0.1	0.1	0.8
Time in novel zone, NPP test	0.2	0.2	0.8	-0.9	0.2	-0.3	-0.5	-0.4	-0.4	0.3
Total zone transitions, NPP test	0.1	0.2	0.3	-0.4	0.5	-0.5	-0.5	-0.4	-0.3	0.2
Total locomotion distance, NPP test	0.1	0.2	0.3	-0.4	0.6	-0.5	-0.6	-0.4	-0.3	-0.0
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.1	0.0	0.1	-0.0	0.2	0.3	0.3
Intraocular pressure	0.7	1.0	3.9	-2.0	0.9	-0.8	-1.0	-0.3	-0.1	0.6
Delta distance traveled before/after self-admin	0.7	0.7	2.4	1.6	-0.9	0.8	0.9	0.5	0.2	0.3
Delta ambulatory time before/after self-admin	0.5	0.6	3.8	1.9	-0.3	0.2	0.4	-0.1	-0.4	-0.5
Parametrial fat weight	0.9	2.2	3.4	0.0	-1.5	1.6	1.6	1.7	1.8	1.2
Pavlov. Cond. lever latency	1.2	1.5	1.9	0.2	-1.4	1.4	1.3	1.3	1.3	1.1
Pavlov. Cond. magazine entry latency	0.6	0.8	1.1	-0.3	1.0	-1.0	-1.0	-1.0	-0.9	-1.0
Pavlov. Cond. change in total contacts	2.2	2.3	2.8	0.6	1.7	-1.6	-1.5	-1.7	-1.7	-1.5
Pavlov. Cond. index score	1.7	2.1	2.8	-0.6	1.7	-1.6	-1.6	-1.6	-1.5	-1.3
Pavlov. Cond. latency score	1.0	1.3	1.7	-0.3	1.3	-1.2	-1.3	-1.3	-1.2	-1.0
Pavlov. Cond. lever contacts	1.6	1.9	2.5	-0.4	1.6	-1.5	-1.6	-1.5	-1.4	-1.2
Pavlov. Cond. magazine entry number	2.0	2.6	3.4	0.9	-1.8	1.8	1.8	1.7	1.6	1.4
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.2	0.3	-0.3	-0.4	-0.3	-0.3	-0.2
Pavlov. Cond. lever-magazine prob. diff.	1.5	1.9	2.7	-0.7	1.6	-1.6	-1.6	-1.5	-1.4	-1.1
Pavlov. Cond. response bias	3.8	4.7	6.2	-0.8	2.5	-2.4	-2.4	-2.4	-2.3	-1.9
Pavlov. Cond. lever latency	1.1	1.5	2.6	-0.0	-1.4	1.3	1.1	1.2	1.1	1.6
Pavlov. Cond. magazine entry latency	0.5	0.6	0.8	-0.3	0.8	-0.8	-0.8	-0.9	-0.9	-0.8
Pavlov. Cond. change in total contacts	1.7	2.7	3.8	-0.7	2.0	-1.9	-1.8	-1.7	-1.6	-1.6
Pavlov. Cond. index score	1.3	1.8	2.2	-0.5	1.5	-1.5	-1.4	-1.4	-1.4	-1.4
Pavlov. Cond. latency score	1.0	1.3	1.7	-0.3	1.3	-1.3	-1.1	-1.2	-1.2	-1.3
Pavlov. Cond. lever contacts	1.1	1.5	2.9	0.2	1.4	-1.3	-1.1	-1.2	-1.2	-1.7
Pavlov. Cond. magazine entry number	0.3	0.3	0.4	0.4	-0.6	0.6	0.6	0.6	0.6	0.6
Pavlov. Cond. intertrial magazine entries	0.9	1.3	1.7	1.3	-1.0	1.1	1.2	1.2	1.3	0.7
Pavlov. Cond. lever-magazine prob. diff.	1.5	2.1	2.7	-0.5	1.6	-1.6	-1.5	-1.5	-1.5	-1.5
Pavlov. Cond. response bias	1.4	1.9	2.5	-0.4	1.6	-1.5	-1.4	-1.4	-1.3	-1.6
Time in closed arm before self-admin	2.0	2.6	6.8	1.6	1.0	-1.1	-0.9	-1.6	-1.8	-2.6
Time in closed arm after self-admin	1.9	2.0	4.8	1.0	1.3	-1.3	-1.1	-1.3	-1.4	-2.2
Time in open arm before self-admin	0.5	0.5	2.2	-1.5	0.3	-0.2	-0.3	0.2	0.3	1.0
Time in open arm after self-admin	0.8	0.9	2.4	-1.2	-0.7	0.7	0.5	0.8	0.9	1.6
Bone: periosteal estimation	0.1	0.3	0.4	0.5	-0.6	0.6	0.6	0.6	0.6	-0.1
Bone: periosteal perimeter	0.1	0.1	0.3	-0.2	-0.2	0.3	0.3	0.4	0.5	-0.1
Bone: post-yield work	0.4	0.5	0.8	-0.2	-0.9	0.8	0.8	0.8	0.7	0.7
Progressive ratio test 1 active lever presses	0.8	1.0	2.7	-0.1	-1.1	1.0	0.9	0.9	0.8	1.6
Progressive ratio test 1 breakpoint	0.7	0.9	2.2	-0.1	-1.1	1.0	0.9	0.8	0.7	1.5
Progressive ratio test 1 inactive lever presses	1.1	1.5	2.6	-0.4	1.3	-1.4	-1.3	-1.4	-1.6	-0.9
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.0	-0.2	0.2	0.2	0.3	0.2	0.6
Progressive ratio test 2 breakpoint	0.1	0.1	0.5	-0.1	-0.3	0.3	0.3	0.3	0.2	0.7
Progressive ratio test 2 inactive lever presses	0.3	0.5	1.5	-1.2	0.4	-0.5	-0.7	-0.5	-0.6	0.7
Incentive Sensitization - Responses	0.6	0.8	1.4	0.1	-0.7	0.8	0.9	1.2	1.2	1.0
Incentive Sensitization - Breakpoint	0.6	0.7	1.3	0.2	-0.7	0.7	0.9	1.1	1.1	0.9
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.7	0.1	-0.4	0.3	0.2	0.2	0.2	0.9
Progressive ratio	2.9	4.5	5.8	1.1	-2.3	2.4	2.4	2.4	2.4	1.6
Food seeking constrained by brief footshock	0.6	0.8	3.4	1.9	-0.6	0.6	0.9	0.6	0.4	-0.3
Seeking ratio, punishment vs. effort	1.1	1.6	2.5	0.5	1.3	-1.3	-1.1	-1.5	-1.6	-1.4
Retroperitoneal fat weight	0.5	2.1	3.3	-0.6	-1.5	1.5	1.4	1.6	1.8	1.5
Reaction time number correct	0.6	1.1	1.5	-1.2	1.2	-1.2	-1.2	-0.9	-0.8	-0.3
Reaction time mean minus median	0.2	0.5	2.6	-1.6	0.4	-0.3	-0.6	-0.2	0.1	0.4
Reaction time mean minus median AUC	0.2	0.4	2.3	-1.5	0.4	-0.3	-0.5	-0.2	-0.0	0.4
Reaction time num false alarms	1.6	2.2	9.5	-3.1	1.0	-1.0	-1.5	-1.0	-0.6	0.7
Reaction time num false alarms AUC	1.4	2.2	8.2	-2.9	1.2	-1.1	-1.6	-1.1	-0.7	0.4
Reaction time trials correct on left	0.6	1.1	1.5	-1.2	1.2	-1.2	-1.2	-0.9	-0.8	-0.3
Reaction time trials on left	0.5	1.0	1.7	-1.3	1.2	-1.1	-1.2	-0.9	-0.7	-0.2
Reaction time mean	0.7	1.1	4.5	-2.1	0.9	-0.9	-1.0	-0.6	-0.4	0.3
Reaction time mean AUC	0.7	1.2	4.6	-2.1	0.9	-0.9	-1.0	-0.6	-0.5	0.4
Median of all reaction times	0.9	1.3	3.6	-1.9	1.2	-1.2	-1.2	-0.9	-0.8	-0.0
Reaction time omissions	1.8	2.6	5.5	-2.3	-1.3	1.3	0.9	1.3	1.7	1.9
Reaction time false alarm rate	0.5	0.7	3.4	-1.8	0.4	-0.4	-0.7	-0.5	-0.2	0.4
Reaction time premature initiation rate	1.1	1.5	6.5	2.6	-0.8	0.9	1.1	0.6	0.5	-0.9
Reaction time premature initiations	0.3	0.5	2.7	1.6	-0.3	0.4	0.5	0.3	0.3	-0.7
Std. dev. reaction times	0.4	0.7	3.2	-1.8	-0.0	0.1	-0.1	0.3	0.5	1.0
Reaction time trials completed	0.5	1.0	1.7	-1.3	1.2	-1.1	-1.2	-0.9	-0.7	-0.2
Reaction time trials AUC	0.5	0.9	1.8	-1.4	1.1	-1.1	-1.1	-0.8	-0.6	-0.1
Run reversals in cocaine runway, females	0.5	0.5	1.5	-0.9	-0.6	0.6	0.4	0.5	0.6	1.2
Run reversals in cocaine runway, males	0.1	0.1	0.2	-0.2	-0.1	0.2	0.1	0.3	0.4	0.4
Latency to leave start box in cocaine runway	2.0	2.2	3.0	-0.2	-1.6	1.6	1.5	1.6	1.7	1.7
Latency to leave start box in cocaine runway, F	0.9	1.1	1.8	-0.7	-1.2	1.1	0.9	1.0	1.0	1.3
Latency to leave start box in cocaine runway, M	2.0	1.8	2.5	0.7	-1.4	1.4	1.5	1.5	1.6	1.2
Std. dev. time between licks in bursts	0.5	0.6	1.8	0.4	0.9	-0.7	-0.6	-0.7	-0.6	-1.3
Total sessions with >9 infusions	0.3	0.3	0.7	-0.0	-0.8	0.7	0.4	0.2	0.1	0.8
Short access day 1 total inactive lever presses	0.5	0.6	1.9	-0.0	-1.4	1.0	0.8	0.3	0.1	0.8
Short access day 10 total inactive lever presses	0.5	1.3	1.9	0.4	1.2	-1.2	-0.9	-1.2	-1.3	-1.4
Short access day 1 total infusions	0.2	0.3	0.8	-0.9	-0.4	0.2	-0.1	-0.2	-0.4	0.9
Short access day 10 total infusions	0.4	0.5	1.3	0.2	-1.1	0.9	0.6	0.4	0.2	0.8
Short access total infusions	0.4	0.5	1.2	-0.2	-1.1	0.9	0.6	0.4	0.3	1.1
Short access day 1 locomotion	0.7	0.9	2.8	-1.7	0.5	-0.6	-1.0	-0.8	-0.8	0.5
Short access day 10 total locomotion	0.4	0.6	1.9	-0.3	0.6	-0.8	-0.7	-1.0	-1.4	-0.2
Short access total locomotion	0.3	0.3	0.9	-0.7	0.1	-0.4	-0.5	-0.7	-1.0	0.3
One hour access (0.3 mA shock)	0.9	1.0	2.4	-0.2	-1.0	1.0	0.7	1.1	1.0	1.6
Compulsive drug intake	0.0	0.0	0.0	0.2	-0.1	0.0	-0.1	-0.0	-0.1	-0.1
One hour access (shock baseline)	0.3	0.5	1.6	-0.3	-0.7	0.6	0.5	0.7	0.6	1.3
Social response proportion	0.1	0.1	0.3	-0.0	-0.1	0.2	0.3	0.4	0.5	-0.0
Social responses	0.0	0.1	0.2	-0.3	-0.0	0.1	0.2	0.3	0.4	-0.2
Social time	0.5	0.6	2.4	1.6	0.0	-0.0	0.2	-0.2	-0.4	-1.3
Soleus weight	0.0	0.0	0.1	0.2	-0.3	0.2	0.3	0.1	-0.1	-0.2
Bone: stiffness	0.2	0.4	0.7	-0.2	-0.6	0.6	0.6	0.7	0.9	0.4
Tibialis anterior weight	0.3	1.0	1.5	-1.2	1.1	-1.1	-1.1	-0.9	-0.8	-0.7
Time to tail flick, vehicle, before self-admin	2.9	3.1	4.6	0.6	-1.9	2.0	1.8	2.0	2.1	1.3
Time to tail flick, vehicle, after self-admin	1.4	1.9	2.7	1.3	-1.6	1.5	1.6	1.3	1.2	0.7
Time to tail flick, test, before self-admin	5.7	5.9	10.0	-0.8	-2.6	2.6	2.1	2.4	2.6	3.2
Time to tail flick, test, after self-admin	0.3	0.3	1.0	0.9	0.3	-0.3	-0.2	-0.4	-0.4	-1.0
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	0.5	-0.3	0.2	0.3	0.1	-0.0	-0.1
Delta time to tail flick, test, before/after SA	4.4	4.5	8.6	0.6	2.2	-2.1	-1.9	-2.2	-2.2	-2.9
Tibia length	0.1	0.4	2.0	-1.4	0.3	-0.3	-0.5	-0.3	-0.2	0.4
Ambulatory time before self-admin	1.3	1.9	4.4	-2.1	1.4	-1.3	-1.6	-1.2	-1.0	-0.4
Ambulatory time after self-admin	0.3	0.4	0.8	0.3	0.6	-0.6	-0.6	-0.8	-0.9	-0.5
Bone: tissue strength	0.6	0.6	1.3	0.3	0.8	-0.8	-0.7	-0.7	-0.7	-1.1
Total heroin consumption	0.1	0.1	0.6	-0.3	0.0	-0.0	-0.1	-0.0	0.0	0.8
Bone: trabecular number	0.6	1.0	5.4	2.3	-0.3	0.3	0.6	0.3	0.0	-0.9
Bone: trabecular spacing	0.3	0.4	1.9	-1.4	0.4	-0.3	-0.5	-0.2	0.1	0.3
Bone: trabecular thickness	0.8	1.1	4.7	2.2	-0.8	0.7	1.0	0.5	0.2	-0.6
Bone: trabecular tissue density	0.5	0.7	1.7	-1.2	-0.7	0.7	0.4	0.6	0.7	1.3
Water consumed over 24 hours	0.5	0.7	3.1	1.7	-0.5	0.4	0.8	0.3	0.1	-0.7
Number of responses in last shaping day	1.3	1.4	2.1	-1.5	1.2	-1.2	-1.5	-1.3	-1.1	-0.3