LOC120097534

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC120097534	0.03	0.03	4.9e-03	0.02	0.02	0.02	0.02	2.3e-03	3.2e-03	4.4e-03	5.7e-03
2	RMTg	gene expression	LOC120097534	0.15	0.11	2.6e-03	0.02	0.04	0.02	0	1.1e-01	2.8e-02	9.3e-02	2.5e-01
3	PL	gene expression	LOC120097534	0.03	0.02	5.4e-04	0.04	0.03	0.04	0.04	6.0e-05	3.4e-04	7.4e-05	7.0e-05
4	Adipose	mRNA stability	LOC120097534	0.12	0.07	3.6e-12	0.05	0.08	0.07	0.07	1.1e-06	2.6e-09	4.2e-08	7.8e-08
5	Adipose	intron excision ratio	chr1_249147311_249150412	0.02	0.02	9.7e-03	0	0	0	0	3.2e-01	7.6e-02	2.6e-01	2.5e-01
6	Adipose	gene expression	LOC120097534	0.51	0.15	0.0e+00	0.34	0.35	0.34	0.34	8.7e-39	8.0e-41	1.1e-38	1.2e-39

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.7	1.3	1.5	1.2	-1.2	1.0	1.1	1.1	-1.1
Area under the delay curve	0.8	1.2	1.5	-1.0	1.2	-1.2	-1.1	-1.1	0.9
BMI with tail	0.4	1.3	1.7	1.3	-1.3	1.2	1.1	1.0	-0.8
BMI without tail	0.0	0.2	0.3	0.6	-0.4	0.3	0.5	0.2	-0.3
Body weight	0.2	0.8	1.6	1.3	-0.7	1.2	0.7	0.6	-0.4
Weight adjusted by age	0.0	0.1	0.2	0.2	-0.5	0.3	0.2	0.3	-0.0
Bone surface	1.6	3.1	3.3	1.8	-1.8	1.6	1.7	1.8	-1.8
Bone volume	1.8	3.5	4.2	2.1	-1.9	1.8	1.8	1.9	-1.9
Breakpoint value in progressive ratio session	0.3	0.5	1.7	0.2	0.7	-1.3	-0.3	-0.7	0.3
Number of licking bursts	0.9	2.9	4.3	-2.1	1.5	-1.7	-1.6	-1.6	1.5
Context. condit. distance diff. score	0.3	0.4	0.7	0.8	-0.6	0.5	0.7	0.5	-0.6
Locomotion velocity, session 1	4.5	5.1	6.1	-2.4	2.2	-2.5	-2.2	-2.3	1.9
Locomotion distance, session 1	1.9	2.4	2.7	-1.4	1.6	-1.6	-1.6	-1.5	1.5
Locomotion velocity, session 2	0.7	0.9	1.7	-1.1	0.9	-1.3	-0.8	-0.8	0.5
Locomotion distance, session 2	0.9	1.3	2.2	-1.5	1.1	-0.9	-1.2	-1.1	1.0
Locomotion velocity, session 3	0.1	0.1	0.1	-0.2	0.3	0.1	-0.3	-0.2	0.2
Locomotion distance, session 3	0.1	0.1	0.3	0.3	0.0	0.5	0.1	0.2	-0.1
Stereotopy head waving bouts, day 3	0.2	0.3	0.5	-0.3	0.5	-0.5	-0.5	-0.6	0.7
Stereotopy head waving duration, day 3	0.5	0.6	0.8	-0.6	0.6	-0.8	-0.7	-0.8	0.9
Locomotion velocity, session 7	0.6	0.7	1.1	0.6	-0.8	1.0	0.8	0.9	-0.9
Locomotion distance, session 7	1.0	1.2	1.8	0.6	-1.0	1.3	1.0	1.1	-1.3
Stereotopy head waving bouts, day 7	2.4	2.8	3.6	-1.3	1.7	-1.8	-1.6	-1.7	1.9
Stereotopy head waving duration, day 7	0.9	1.2	1.9	-0.7	1.1	-1.1	-1.0	-1.1	1.4
Locomotion velocity, session 8	0.0	0.1	0.1	-0.3	0.2	-0.3	0.0	-0.2	-0.3
Locomotion distance, session 8	0.0	0.1	0.1	-0.3	0.2	-0.3	-0.1	-0.3	0.1
Degree of sensitization distance	0.0	0.1	0.2	-0.5	-0.1	-0.3	-0.0	-0.1	-0.0
Degree of sensitization stereotypy	2.7	3.0	3.9	-1.4	1.8	-1.8	-1.7	-1.8	2.0
Conditioned locomotion	1.7	1.9	2.6	1.6	-1.5	1.4	1.4	1.3	-1.1
Cocaine response after cond. corrected	0.1	0.1	0.2	-0.3	0.2	-0.4	-0.3	-0.4	0.4
Cocaine response after cond. not corrected	0.2	0.3	0.4	-0.6	0.6	-0.6	-0.6	-0.6	0.6
Cocaine response before conditioning	0.9	1.1	1.6	-1.1	1.3	-0.9	-1.2	-1.0	0.9
Saline control response	1.9	2.6	3.0	-1.4	1.7	-1.6	-1.6	-1.7	1.5
Bone: connectivity density	2.3	3.7	4.5	1.7	-2.0	1.6	2.0	2.0	-2.1
Bone: cortical apparent density	1.6	2.5	3.2	-1.8	1.4	-1.6	-1.5	-1.6	1.5
Bone: cortical area	1.1	1.8	4.0	2.0	-1.1	1.5	1.2	1.2	-0.9
Bone: cortical porosity	0.1	0.1	0.4	-0.6	0.1	-0.5	-0.3	-0.3	0.3
Bone: cortical porosity	0.0	0.0	0.1	-0.3	-0.0	-0.1	-0.1	-0.0	0.2
Bone: cortical thickness	0.5	0.9	1.5	-0.1	1.1	-0.8	-0.9	-1.0	1.2
Bone: cortical thickness	2.1	2.6	3.3	-1.3	1.8	-1.8	-1.5	-1.7	1.5
Bone: cortical tissue density	1.6	2.5	3.4	-1.8	1.4	-1.7	-1.5	-1.6	1.5
Condit. Reinf. active minus inactive responses	0.5	0.5	0.8	-0.7	0.8	-0.5	-0.9	-0.6	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.3	0.4	-0.2	-0.4	-0.2	0.2
Condit. Reinf. active responses	0.3	0.4	0.7	-0.7	0.7	-0.3	-0.8	-0.6	0.6
Condit. Reinf. inactive responses	0.3	0.4	0.5	-0.7	0.5	-0.3	-0.7	-0.6	0.7
Incentive salience index mean	0.4	0.5	0.7	-0.7	0.9	-0.6	-0.8	-0.6	0.5
Condit. Reinf. lever presses	0.3	0.5	0.7	-0.7	0.8	-0.8	-0.6	-0.6	0.3
Condit. Reinf. active minus inactive responses	1.8	2.7	3.4	1.5	-1.7	1.8	1.6	1.6	-1.6
Condit. Reinf. active-inactive response ratio	0.8	1.3	1.5	1.0	-1.2	1.2	1.2	1.0	-1.1
Condit. Reinf. active responses	1.4	2.0	2.4	1.4	-1.3	1.5	1.4	1.3	-1.3
Condit. Reinf. inactive responses	0.0	0.0	0.2	0.4	0.1	0.2	0.2	0.1	-0.1
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.3	0.3	-0.3	-0.1	-0.1	-0.2
Condit. Reinf. lever reinforcers received	0.7	1.0	1.2	1.0	-0.9	1.1	1.0	0.9	-1.0
Conditioned reinforcement - actives	0.4	1.5	2.1	-1.4	1.2	-0.4	-1.5	-1.1	1.5
Conditioned reinforcement - inactives	0.2	0.6	1.1	-0.6	0.8	-1.0	-0.7	-0.7	0.6
Conditioned locomotion	0.6	0.9	1.2	-1.0	0.9	-0.9	-1.1	-0.7	0.9
Patch foraging indifference point 0 sec	0.0	0.1	0.2	-0.4	0.4	-0.3	-0.3	-0.2	0.2
Patch foraging indifference point AUC	1.8	4.2	5.9	-1.8	2.4	-2.0	-2.1	-2.2	1.7
Delay disc. indifference point, 0s delay	0.5	0.5	0.8	0.7	-0.9	-0.1	0.9	0.7	-0.9
Delay disc. indifference point, 16s delay	0.6	0.9	1.3	-1.1	1.0	-0.9	-0.9	-0.9	0.8
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.2	0.0	-0.1	-0.0	0.0	-0.3
Delay disc. indifference point, 24s delay	2.9	4.6	5.4	-2.2	2.3	-1.5	-2.3	-2.2	2.3
Delay disc. indifference point, 4s delay	0.6	0.6	0.8	-0.6	0.8	-0.9	-0.8	-0.9	0.8
Delay disc. indifference point, 8s delay	2.1	3.5	4.5	-1.7	2.0	-2.1	-1.9	-1.8	1.6
Indifference point function ln k	1.3	4.0	5.0	1.9	-2.2	2.1	2.0	2.0	-1.7
Indifference point function log k	1.3	4.0	5.0	1.9	-2.2	2.1	2.0	2.0	-1.7
Patch foraging total patch changes 0 sec	0.0	0.1	0.1	-0.4	0.4	-0.1	-0.2	-0.2	0.2
Patch foraging total patch changes 12 sec	3.2	4.3	5.2	-2.2	2.3	-2.2	-2.0	-2.1	1.7
Patch foraging total patch changes 18 sec	0.7	1.7	2.1	-1.2	1.4	-1.2	-1.3	-1.3	1.2
Patch foraging total patch changes 24 sec	0.2	0.6	1.0	-0.5	1.0	-0.7	-1.0	-0.7	0.8
Patch foraging total patch changes 6 sec	3.1	5.2	6.9	-2.2	2.6	-1.9	-2.4	-2.3	2.2
Patch foraging time to switch 0 sec	0.2	1.0	1.7	-1.0	0.9	-1.3	-0.8	-1.0	0.8
Patch foraging water rate 0 sec	0.5	1.8	3.0	1.7	-1.3	1.3	1.3	1.3	-1.2
Patch foraging water rate 12 sec	0.1	0.4	0.8	0.9	-0.6	0.7	0.6	0.6	-0.4
Patch foraging water rate 18 sec	0.2	0.3	0.7	0.6	-0.6	0.8	0.4	0.6	-0.2
Patch foraging water rate 24 sec	0.3	0.5	1.0	1.0	-0.7	0.5	0.7	0.6	-0.6
Patch foraging water rate 6 sec	0.1	0.2	0.4	0.6	-0.3	0.3	0.4	0.4	-0.4
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	-0.0	0.4	0.1	0.1	-0.2
Distance traveled before self-admin	0.0	0.0	0.1	-0.3	0.0	0.2	-0.1	0.0	-0.1
Distance traveled after self-admin	0.4	0.6	1.5	0.1	-0.7	1.2	0.6	0.8	-0.9
Extensor digitorum longus weight	0.1	0.3	1.1	0.6	-0.6	1.1	0.3	0.3	0.0
Bone: elastic displacement	0.1	0.1	0.4	0.3	-0.6	0.1	0.4	0.3	-0.0
Bone: elastic work	0.3	0.4	0.6	0.8	-0.8	0.4	0.7	0.7	-0.4
Bone: endosteal estimation	3.0	7.4	7.6	2.7	-2.7	2.7	2.7	2.8	-2.7
Bone: endosteal perimeter	3.0	7.3	7.7	2.7	-2.7	2.7	2.6	2.8	-2.7
Epididymis fat weight	1.2	5.9	7.0	2.6	-2.5	2.1	2.6	2.2	-2.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	0.3	0.0	-0.5	0.1	0.0	-0.2
Delta time in open arm before/after self-admin	0.7	0.8	1.0	0.9	-0.8	0.8	0.9	0.9	-1.0
Diff in mean of infusions in LGA sessions	0.8	1.4	2.5	1.6	-1.1	0.1	1.3	1.1	-1.3
Delay discount exponential model param	1.0	1.3	1.5	1.1	-1.2	1.1	1.2	1.2	-1.0
Extinction: sum of active levers before priming	0.2	0.3	0.8	0.9	-0.4	0.1	0.7	0.4	-0.5
Active lever presses in extinction session 6	0.7	0.7	1.3	1.1	-0.9	-0.0	1.1	0.6	-0.7
Bone: final force	0.1	0.1	0.5	0.7	-0.2	0.4	0.3	0.3	-0.2
Bone: final moment	0.2	0.4	0.9	0.9	-0.4	0.6	0.5	0.5	-0.4
Food consumed during 24 hour testing period	0.5	0.9	1.2	-0.9	1.1	-0.9	-1.0	-0.9	1.0
Glucose	0.2	0.4	0.5	0.6	-0.5	0.7	0.6	0.7	-0.7
Heart weight	1.0	1.7	2.6	1.6	-1.1	1.3	1.3	1.3	-1.1
Delay discount hyperbolic model param	0.6	0.8	1.0	0.9	-1.0	0.9	1.0	0.9	-0.8
Intermittent access intake day 1-15 change	0.3	1.5	3.8	1.0	-1.2	1.9	0.9	1.2	-0.9
Intermittent access intake escalation	0.4	2.1	4.6	1.2	-1.4	2.1	1.1	1.4	-1.0
Intermittent access intake escalation 2	0.5	0.9	1.5	0.8	-1.1	1.2	0.7	1.0	-0.6
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.2	-0.3	-0.0	0.2	0.4	-0.5
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.5	0.4	-0.6	0.1	0.3	0.7	-0.4
Intermitt. access escalation Index	0.3	0.9	1.0	0.9	-1.0	1.0	1.0	0.9	-1.0
Intermittent access day 1 total infusions	0.1	0.2	0.8	-0.2	0.2	-0.9	-0.1	-0.2	-0.2
Intermittent access day 15 total infusions	0.7	1.7	2.2	1.4	-1.2	1.5	1.2	1.3	-1.2
Intermittent access terminal intake (last 3 days)	0.2	0.3	0.4	0.6	-0.5	0.5	0.5	0.6	-0.6
Intermittent access total infusions	0.1	0.1	0.2	0.4	-0.3	0.2	0.3	0.3	-0.5
Intermittent access day 1 locomotion	0.2	0.3	0.5	0.7	-0.6	0.2	0.5	0.7	-0.5
Intermittent access day 15 total locomotion	0.2	0.7	1.3	-0.7	0.9	-1.1	-0.8	-0.8	0.7
Intermittent access total locomotion	0.2	0.2	0.7	-0.3	0.4	-0.9	-0.4	-0.3	0.2
Intermittent access standard deviation	0.1	0.3	0.6	0.7	-0.6	0.1	0.5	0.8	-0.6
Left kidney weight	0.0	0.3	0.6	-0.3	0.7	-0.6	-0.5	-0.6	0.2
Right kidney weight	0.1	0.8	1.5	-0.5	1.2	-0.6	-0.9	-1.1	0.9
Cocaine induced anxiety	0.8	2.1	2.7	1.5	-1.5	0.9	1.6	1.4	-1.6
Post-drug Anxiety	2.5	2.9	3.6	1.8	-1.8	1.3	1.9	1.7	-1.8
Baseline Anxiety	0.2	0.3	0.8	0.5	-0.4	0.9	0.5	0.5	-0.4
Tail length	0.0	0.1	0.1	0.4	0.0	0.4	0.1	0.1	-0.1
Length with tail	0.1	0.4	0.7	-0.2	0.8	-0.1	-0.7	-0.6	0.7
Length without tail	0.0	0.2	0.4	-0.2	0.6	0.0	-0.6	-0.4	0.6
Times rat made contact with spout	0.3	0.3	0.9	-0.9	0.5	-0.4	-0.5	-0.4	0.2
Lifetime Intake	0.2	0.2	0.4	0.5	-0.4	0.2	0.4	0.4	-0.6
Liver weight, left	0.0	0.0	0.0	-0.1	0.0	0.1	-0.0	0.0	-0.1
Liver weight, right	0.5	0.9	1.3	1.1	-0.8	1.1	0.8	0.9	-0.7
Locomotor activity	0.0	0.0	0.0	0.1	0.1	-0.2	0.0	-0.0	0.1
Locomotor testing distance	0.0	0.1	0.4	0.2	0.2	-0.6	0.0	0.0	-0.0
Locomotor testing rearing	0.1	0.4	0.6	0.8	-0.6	0.0	0.6	0.7	-0.6
Locomotion in novel chamber	3.0	4.0	5.3	1.9	-2.1	2.3	2.0	1.9	-1.8
Locomotion in novel chamber post-restriction	0.0	0.0	0.1	-0.1	0.3	0.1	-0.2	-0.2	0.1
Fecal boli incidents, locomotor time 1	0.0	0.0	0.0	0.1	-0.1	0.2	0.1	-0.0	0.2
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.2	0.2	0.3	-0.2	-0.2	0.2
Time >=10cm from walls, locomotor time 1	0.6	0.7	1.0	-0.9	1.0	-1.0	-0.8	-0.7	0.7
Bouts of movement, locomotor time 1	1.4	1.8	3.0	-1.7	1.3	-0.9	-1.4	-1.4	1.3
Total resting periods, locomotor time 1	2.8	3.3	4.4	-2.1	1.8	-1.5	-1.8	-1.8	1.7
Rest time, locomotor task time 1	0.6	1.0	1.6	-1.3	1.0	-0.5	-1.0	-1.1	1.1
Distance moved, locomotor task time 1	0.2	0.6	0.9	0.9	-0.6	0.7	0.7	0.8	-0.7
Vertical activity count, locomotor time 1	0.0	0.2	0.4	0.4	-0.3	0.4	0.4	0.6	-0.6
Time >=10cm from walls, locomotor time 2	0.2	0.6	0.7	-0.7	0.9	-0.8	-0.8	-0.7	0.7
Bouts of movement, locomotor time 2	1.4	4.6	6.9	-2.6	2.2	-2.3	-2.0	-2.2	1.4
Total resting periods, locomotor time 2	1.3	5.3	7.5	-2.7	2.4	-2.3	-2.2	-2.4	1.6
Rest time, locomotor task time 2	1.6	2.6	3.4	-1.6	1.6	-1.4	-1.6	-1.7	1.8
Distance moved, locomotor task time 2	0.9	1.2	1.7	1.3	-1.0	0.9	1.0	1.2	-1.1
Vertical activity count, locomotor time 2	0.1	0.3	0.6	0.5	-0.4	0.5	0.4	0.7	-0.8
Light reinforcement 1	0.1	0.4	0.9	-0.9	0.6	-0.7	-0.6	-0.6	0.4
Light reinforcement 2	1.5	3.4	4.5	-2.0	1.8	-2.1	-1.8	-1.9	1.5
Bone: marrow area	3.0	7.4	7.6	2.7	-2.7	2.7	2.7	2.8	-2.7
Bone: maximum diameter	3.9	7.8	9.9	3.2	-2.8	2.8	2.7	2.8	-2.5
Bone: maximum force	0.2	0.4	1.1	1.1	-0.5	0.6	0.5	0.5	-0.4
Bone: maximum moment	0.4	0.7	1.5	1.2	-0.7	0.8	0.7	0.7	-0.5
Mean time between licks in bursts	0.0	0.3	0.4	0.7	-0.5	0.6	0.5	0.6	-0.3
Mean num. licks in bursts	1.0	2.6	2.9	1.7	-1.5	1.7	1.6	1.7	-1.6
Cd content in liver	1.2	1.4	1.7	-1.3	1.2	-1.1	-1.2	-1.2	1.0
Co content in liver	0.3	0.3	0.6	0.8	-0.3	0.6	0.4	0.6	-0.5
Cu content in liver	5.2	6.2	7.7	-2.7	2.5	-2.8	-2.4	-2.3	2.1
Fe content in liver	2.2	2.8	3.5	-1.5	1.6	-1.9	-1.6	-1.7	1.6
K content in liver	1.4	1.4	2.1	-1.5	1.1	-1.3	-1.1	-1.2	0.9
Mg content in liver	1.3	1.5	1.7	-1.3	1.1	-1.2	-1.1	-1.3	1.2
Mn content in liver	6.5	7.3	8.8	-3.0	2.5	-2.9	-2.6	-2.7	2.5
Na content in liver	1.7	2.0	2.3	-1.2	1.4	-1.5	-1.3	-1.5	1.5
Rb content in liver	0.1	0.1	0.2	-0.2	0.4	-0.3	-0.4	-0.4	0.5
Se content in liver	22.2	26.3	27.7	-5.3	5.1	-5.2	-5.1	-5.1	4.9
Sr content in liver	0.5	0.5	0.6	-0.8	0.7	-0.7	-0.7	-0.6	0.5
Zn content in liver	2.4	2.7	2.9	-1.7	1.7	-1.7	-1.7	-1.6	1.6
Bone: minimum diameter	7.5	14.4	19.3	4.4	-3.7	4.0	3.6	3.7	-3.3
Time in familiar zone, hab. session 1	0.2	0.3	0.4	0.4	-0.6	0.6	0.5	0.5	-0.5
Time in novel zone, hab. session 1	0.6	0.6	0.8	-0.8	0.8	-0.5	-0.9	-0.7	0.9
Total zone transitions, hab. session 1	0.2	0.2	0.3	-0.6	0.5	-0.3	-0.6	-0.4	0.5
Total locomotion distance, hab. session 1	2.2	3.1	3.4	-1.8	1.8	-1.7	-1.9	-1.7	1.7
Locomotion velocity, hab. session 1	3.5	4.9	5.4	-2.2	2.3	-2.1	-2.3	-2.2	2.2
Time in familiar zone, hab. session 2	0.4	0.4	0.5	0.7	-0.7	0.5	0.7	0.6	-0.6
Time in novel zone, hab. session 2	0.5	0.6	0.8	-0.9	0.8	-0.6	-0.9	-0.7	0.6
Total zone transitions, hab. session 2	0.1	0.2	0.2	-0.4	0.4	-0.3	-0.5	-0.4	0.4
Total locomotion distance, hab. session 2	0.5	0.7	0.8	-0.8	0.9	-0.8	-0.8	-0.9	0.7
Locomotion velocity, hab. session 2	0.7	1.0	1.1	-1.0	1.0	-1.0	-1.0	-1.0	0.9
Novel to familiar place preference ratio	0.0	0.1	0.3	-0.0	0.0	-0.5	-0.2	-0.2	0.1
Novelty place preference	0.0	0.0	0.2	-0.0	-0.0	-0.4	-0.1	-0.1	0.1
Time in novel zone, NPP test	0.0	0.0	0.1	-0.1	0.0	-0.4	-0.2	-0.2	0.1
Total zone transitions, NPP test	0.3	0.5	0.7	-0.7	0.8	-0.5	-0.8	-0.6	0.6
Total locomotion distance, NPP test	2.7	3.8	4.6	-1.9	2.1	-2.0	-2.0	-1.9	1.7
Locomotion velocity, NPP test	2.0	2.8	3.7	-1.6	1.9	-1.8	-1.7	-1.7	1.4
Intraocular pressure	0.1	0.1	0.4	0.2	-0.2	-0.6	0.3	0.0	-0.1
Delta distance traveled before/after self-admin	1.8	2.0	2.3	1.2	-1.5	1.4	1.4	1.5	-1.4
Delta ambulatory time before/after self-admin	1.8	3.1	3.8	1.4	-1.9	2.0	1.7	1.9	-1.7
Parametrial fat weight	0.0	0.0	0.1	0.4	0.3	0.2	0.1	-0.1	0.0
Pavlov. Cond. lever latency	0.2	0.3	0.4	0.3	-0.7	0.6	0.5	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	-0.8	1.1	-0.8	-0.8	-0.7	0.3
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	-0.2	0.4	-0.2	-0.2	-0.1	0.1
Pavlov. Cond. index score	0.8	1.0	1.5	-1.0	1.2	-1.0	-1.0	-0.9	0.7
Pavlov. Cond. latency score	0.4	0.5	1.0	-0.6	1.0	-0.8	-0.7	-0.7	0.5
Pavlov. Cond. lever contacts	0.4	0.5	0.8	-0.6	0.9	-0.8	-0.7	-0.7	0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.3	-0.5	0.2	0.3	0.1	0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.1	-0.5	0.6	-0.5	-0.9	-0.7	1.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.4	-1.0	1.2	-1.0	-1.0	-0.9	0.7
Pavlov. Cond. response bias	0.2	0.3	0.6	-0.6	0.8	-0.5	-0.6	-0.4	0.2
Pavlov. Cond. lever latency	0.3	0.4	0.9	0.5	-0.9	0.9	0.6	0.6	-0.2
Pavlov. Cond. magazine entry latency	0.3	0.5	0.8	-0.8	0.9	-0.7	-0.7	-0.7	0.4
Pavlov. Cond. change in total contacts	0.0	0.0	0.1	0.0	0.2	-0.2	0.1	0.1	-0.3
Pavlov. Cond. index score	0.4	0.7	1.2	-0.9	1.1	-0.9	-0.8	-0.8	0.4
Pavlov. Cond. latency score	0.5	0.8	1.3	-0.9	1.1	-1.0	-0.8	-0.8	0.5
Pavlov. Cond. lever contacts	0.2	0.3	0.7	-0.4	0.8	-0.8	-0.5	-0.5	0.1
Pavlov. Cond. magazine entry number	1.6	2.1	2.9	1.5	-1.7	1.4	1.4	1.4	-1.1
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.1	1.0	-1.0	0.9	0.9	0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	1.3	-0.9	1.1	-1.0	-0.8	-0.8	0.4
Pavlov. Cond. response bias	0.4	0.5	1.0	-0.6	1.0	-0.8	-0.7	-0.6	0.3
Time in closed arm before self-admin	0.0	0.1	0.2	-0.5	0.1	0.2	-0.3	-0.0	0.3
Time in closed arm after self-admin	0.5	0.6	1.2	-0.8	0.5	-0.2	-1.0	-0.5	1.1
Time in open arm before self-admin	0.1	0.1	0.2	0.0	-0.4	-0.0	0.4	0.2	-0.5
Time in open arm after self-admin	0.8	0.9	1.7	0.9	-0.7	0.4	1.2	0.7	-1.3
Bone: periosteal estimation	2.2	5.3	7.3	2.7	-2.2	2.3	2.2	2.2	-2.1
Bone: periosteal perimeter	2.6	5.2	6.5	2.6	-2.3	2.4	2.2	2.2	-2.0
Bone: post-yield work	0.2	0.4	0.7	0.9	-0.6	0.8	0.5	0.6	-0.5
Progressive ratio test 1 active lever presses	0.3	0.5	0.9	-0.7	0.6	-0.6	-0.8	-0.7	0.9
Progressive ratio test 1 breakpoint	0.4	0.6	0.9	-0.7	0.7	-0.7	-0.8	-0.7	0.9
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.4	0.6	-0.5	0.4	0.6	0.5	-0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.4	-0.5	0.5	0.2	-0.6	-0.4	0.5
Progressive ratio test 2 breakpoint	0.2	0.2	0.3	-0.5	0.5	0.2	-0.6	-0.4	0.5
Progressive ratio test 2 inactive lever presses	0.0	0.1	0.2	-0.5	0.2	-0.4	-0.4	-0.2	0.2
Incentive Sensitization - Responses	0.0	0.1	0.2	-0.4	0.3	0.2	-0.4	-0.1	0.0
Incentive Sensitization - Breakpoint	0.0	0.1	0.2	-0.4	0.3	0.1	-0.4	-0.2	0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.5	0.3	-0.0	-0.7	0.2	-0.1	-0.2
Progressive ratio	0.2	0.6	1.1	0.6	-0.7	1.0	0.8	0.6	-0.8
Food seeking constrained by brief footshock	0.4	0.6	0.8	-0.5	0.9	-0.7	-0.8	-0.8	0.7
Seeking ratio, punishment vs. effort	0.6	1.4	1.7	-0.9	1.3	-1.2	-1.3	-1.1	1.2
Retroperitoneal fat weight	0.2	0.7	1.3	1.1	-0.8	0.5	1.0	0.6	-0.8
Reaction time number correct	0.3	1.0	1.8	0.9	-1.3	0.9	0.9	1.2	-0.7
Reaction time mean minus median	0.1	0.5	0.9	0.8	-0.6	0.5	0.8	0.8	-0.9
Reaction time mean minus median AUC	0.1	0.7	1.1	0.9	-0.8	0.4	1.0	0.9	-1.0
Reaction time num false alarms	0.1	0.1	0.4	0.0	0.2	0.5	-0.4	-0.2	0.6
Reaction time num false alarms AUC	0.1	0.2	0.5	0.1	0.1	0.7	-0.4	-0.1	0.6
Reaction time trials correct on left	0.3	1.0	1.8	0.9	-1.3	0.9	0.9	1.2	-0.7
Reaction time trials on left	0.3	1.0	1.8	0.9	-1.3	0.9	0.9	1.2	-0.7
Reaction time mean	0.0	0.1	0.3	-0.2	0.5	-0.2	-0.4	-0.3	0.2
Reaction time mean AUC	0.1	0.2	0.4	-0.4	0.7	-0.4	-0.5	-0.5	0.3
Median of all reaction times	0.2	0.3	0.5	-0.4	0.7	-0.2	-0.6	-0.6	0.5
Reaction time omissions	0.4	0.6	1.1	0.5	-0.7	0.7	0.8	0.9	-1.0
Reaction time false alarm rate	0.2	0.3	0.7	-0.3	0.7	0.2	-0.7	-0.6	0.8
Reaction time premature initiation rate	0.1	0.2	0.4	-0.5	0.6	-0.1	-0.5	-0.4	0.5
Reaction time premature initiations	0.0	0.0	0.1	0.0	-0.1	0.3	-0.0	0.2	0.0
Std. dev. reaction times	0.1	0.4	0.5	0.6	-0.4	0.6	0.5	0.6	-0.7
Reaction time trials completed	0.3	1.0	1.8	0.9	-1.3	0.9	0.9	1.2	-0.7
Reaction time trials AUC	0.2	0.8	1.6	0.8	-1.2	0.8	0.8	1.1	-0.6
Run reversals in cocaine runway, females	1.4	1.6	2.2	-1.5	1.1	-1.0	-1.4	-1.2	1.3
Run reversals in cocaine runway, males	2.2	2.4	3.2	-1.1	1.7	-1.8	-1.5	-1.6	1.6
Latency to leave start box in cocaine runway	3.2	4.4	5.0	2.1	-2.2	2.1	2.1	2.2	-2.0
Latency to leave start box in cocaine runway, F	5.4	6.7	7.2	2.6	-2.7	2.4	2.6	2.7	-2.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.2	-0.5	0.4	0.2	0.5	-0.2
Std. dev. time between licks in bursts	0.2	0.4	0.7	-0.5	0.6	-0.7	-0.7	-0.6	0.8
Total sessions with >9 infusions	0.0	0.1	0.1	-0.3	0.2	0.1	-0.3	-0.1	0.3
Short access day 1 total inactive lever presses	1.0	2.0	2.6	1.3	-1.5	0.9	1.6	1.4	-1.6
Short access day 10 total inactive lever presses	0.0	0.1	0.4	0.3	-0.1	-0.6	0.3	0.2	-0.1
Short access day 1 total infusions	0.3	0.5	0.9	-0.5	0.7	-1.0	-0.6	-0.8	0.7
Short access day 10 total infusions	0.7	1.1	1.3	-1.1	1.1	-1.0	-1.1	-1.0	1.0
Short access total infusions	0.0	0.0	0.1	-0.1	0.2	-0.4	-0.2	-0.2	0.1
Short access day 1 locomotion	0.1	0.1	0.4	0.1	-0.4	0.6	0.1	0.4	-0.3
Short access day 10 total locomotion	0.2	0.8	1.5	-0.7	0.9	-0.5	-1.0	-0.9	1.2
Short access total locomotion	0.1	0.2	0.4	-0.6	0.3	0.1	-0.6	-0.2	0.5
One hour access (0.3 mA shock)	0.3	0.3	1.2	0.3	-0.4	1.1	0.3	0.4	-0.4
Compulsive drug intake	2.1	3.0	3.7	1.8	-1.8	1.5	1.9	1.7	-1.7
One hour access (shock baseline)	0.1	0.2	0.3	-0.4	0.4	0.5	-0.5	-0.2	0.2
Social response proportion	1.2	1.6	2.1	0.7	-1.4	1.3	1.3	1.3	-1.4
Social responses	1.8	2.3	3.4	1.2	-1.5	1.4	1.6	1.6	-1.9
Social time	0.0	0.0	0.1	0.2	0.1	0.3	-0.0	0.2	-0.2
Soleus weight	1.0	2.9	3.7	1.5	-1.8	1.7	1.7	1.7	-1.9
Bone: stiffness	0.2	0.3	0.8	0.9	-0.4	0.7	0.4	0.4	-0.2
Tibialis anterior weight	0.2	0.7	1.5	0.7	-0.9	1.2	0.7	0.7	-0.5
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.8	-0.9	0.5	-0.8	-0.5	-0.6	0.4
Time to tail flick, vehicle, after self-admin	0.0	0.1	0.1	0.1	-0.4	-0.4	0.3	0.3	-0.2
Time to tail flick, test, before self-admin	0.3	0.3	0.5	0.4	-0.5	0.2	0.6	0.7	-0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.2	-0.3	0.1	-0.1	-0.3	-0.1	0.4
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.3	-0.2	0.1	0.0	0.2	0.1
Delta time to tail flick, test, before/after SA	0.5	0.7	1.1	-0.8	0.7	-0.4	-0.9	-0.8	1.0
Tibia length	0.0	0.0	0.0	0.1	0.0	0.1	0.1	0.1	-0.2
Ambulatory time before self-admin	0.0	0.1	0.1	-0.4	0.1	0.2	-0.3	-0.1	0.1
Ambulatory time after self-admin	0.6	1.0	2.7	0.4	-1.0	1.6	0.7	1.0	-0.9
Bone: tissue strength	0.4	0.4	0.4	0.6	-0.6	0.6	0.6	0.6	-0.6
Total heroin consumption	0.6	0.7	1.5	1.2	-0.3	-0.8	1.0	0.3	-1.1
Bone: trabecular number	0.5	1.0	1.3	1.1	-1.0	0.7	1.0	1.0	-1.1
Bone: trabecular spacing	0.1	0.1	0.2	-0.2	0.5	-0.1	-0.4	-0.4	0.4
Bone: trabecular thickness	1.3	1.9	2.3	1.5	-1.3	1.3	1.3	1.4	-1.4
Bone: trabecular tissue density	0.6	1.0	1.3	1.0	-1.1	1.2	1.0	1.0	-0.6
Water consumed over 24 hours	0.3	0.6	0.9	-1.0	0.7	-0.7	-0.8	-0.7	0.5
Number of responses in last shaping day	0.1	0.2	0.5	-0.2	0.0	0.7	-0.4	-0.0	0.6