Hub : Genes

LOC120096890

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC120096890	0.15	0.1	1.2e-04	0.03	0.03	0.05	0.03	1.1e-04	2.3e-04	4.7e-06	6.2e-04
2	Adipose	gene expression	LOC120096890	0.05	0.04	4.9e-06	0.02	0.03	0.03	0.03	9.1e-04	1.7e-04	2.7e-04	2.7e-04
3	Brain	gene expression	LOC120096890	0.08	0.06	7.9e-06	0.04	0.03	0.04	0.05	8.0e-05	8.3e-04	7.7e-05	1.6e-05
4	pVTA	gene expression	LOC120096890	0.03	0.03	9.1e-03	0.02	0.01	0.01	0.02	7.0e-03	1.9e-02	9.6e-02	8.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	0.1	0.1	0.2	-0.3	-0.4	-0.4	0.2
Area under the delay curve	0.3	0.4	0.7	0.7	0.8	0.7	-0.1
BMI with tail	0.7	2.4	3.3	1.8	-1.8	-1.5	0.8
BMI without tail	0.3	1.6	2.4	0.6	-1.6	-1.5	1.3
Body weight	1.7	7.6	8.6	2.6	-2.9	-2.9	2.5
Weight adjusted by age	0.5	1.5	5.2	-2.3	-0.5	-0.6	0.5
Bone surface	0.2	0.4	0.8	0.5	-0.9	-0.7	0.4
Bone volume	0.3	0.7	1.0	0.6	-0.9	-1.0	0.7
Breakpoint value in progressive ratio session	0.7	1.2	2.3	-1.0	1.5	0.8	-1.0
Number of licking bursts	0.7	2.2	3.0	1.5	-1.3	-1.7	1.4
Context. condit. distance diff. score	0.1	0.2	0.4	-0.1	-0.6	-0.3	0.5
Locomotion velocity, session 1	0.1	0.1	0.3	-0.5	-0.1	0.1	-0.1
Locomotion distance, session 1	0.1	0.2	0.4	-0.1	-0.5	-0.6	0.1
Locomotion velocity, session 2	0.0	0.0	0.1	-0.0	-0.3	-0.1	0.1
Locomotion distance, session 2	0.1	0.1	0.2	-0.2	0.0	0.2	-0.5
Locomotion velocity, session 3	0.2	0.2	0.6	-0.2	0.2	0.5	-0.7
Locomotion distance, session 3	3.7	4.2	5.6	-2.4	1.7	1.9	-2.1
Stereotopy head waving bouts, day 3	0.1	0.1	0.3	0.0	-0.5	-0.3	0.2
Stereotopy head waving duration, day 3	0.6	0.7	1.3	0.6	-1.1	-0.9	0.7
Locomotion velocity, session 7	0.7	0.7	0.9	-0.9	0.6	0.9	-0.9
Locomotion distance, session 7	0.1	0.1	0.2	-0.4	-0.3	-0.1	-0.1
Stereotopy head waving bouts, day 7	0.1	0.2	0.4	-0.4	-0.6	0.2	-0.2
Stereotopy head waving duration, day 7	0.1	0.2	0.7	-0.1	-0.8	-0.0	0.2
Locomotion velocity, session 8	1.5	1.8	2.4	-1.6	1.0	1.3	-1.4
Locomotion distance, session 8	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.2
Degree of sensitization distance	3.0	3.3	3.8	1.7	-1.8	-1.9	1.8
Degree of sensitization stereotypy	0.1	0.1	0.5	-0.1	-0.7	0.2	0.1
Conditioned locomotion	3.0	3.5	4.7	-1.8	1.4	2.2	-2.0
Cocaine response after cond. corrected	0.4	0.5	1.1	1.1	-0.5	-0.8	0.4
Cocaine response after cond. not corrected	0.4	0.6	1.0	1.0	-0.7	-0.9	0.4
Cocaine response before conditioning	0.1	0.1	0.2	-0.1	-0.4	-0.2	-0.2
Saline control response	0.6	0.9	1.8	0.6	-1.4	-0.8	0.8
Bone: connectivity density	0.1	0.2	0.4	-0.6	-0.1	0.3	-0.5
Bone: cortical apparent density	0.7	1.1	2.5	1.6	-0.2	-0.9	1.0
Bone: cortical area	1.2	2.0	2.8	0.6	-1.6	-1.7	1.5
Bone: cortical porosity	3.7	4.0	4.7	-1.9	1.9	2.2	-2.1
Bone: cortical porosity	2.2	2.4	3.0	-1.5	1.4	1.7	-1.6
Bone: cortical thickness	0.6	1.1	1.6	0.6	-1.0	-1.2	1.1
Bone: cortical thickness	1.5	1.9	3.2	1.8	-1.2	-1.4	1.0
Bone: cortical tissue density	0.6	0.9	2.2	1.5	-0.1	-0.8	0.9
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	0.4	-0.6	-0.9	0.3
Condit. Reinf. active-inactive response ratio	0.5	0.5	1.0	0.3	-0.9	-1.0	0.4
Condit. Reinf. active responses	0.0	0.0	0.1	0.1	-0.4	-0.1	0.2
Condit. Reinf. inactive responses	0.1	0.1	0.4	-0.3	0.0	0.6	0.1
Incentive salience index mean	0.1	0.1	0.2	-0.4	0.1	0.2	-0.4
Condit. Reinf. lever presses	0.9	1.3	1.7	-1.3	0.7	1.3	-1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.4	-0.3	-0.0	0.0	-0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.6	-0.2	-0.2	-0.0
Condit. Reinf. active responses	0.8	1.2	2.1	-1.4	0.7	0.6	-1.3
Condit. Reinf. inactive responses	1.6	2.4	5.1	-2.3	1.0	1.1	-1.5
Condit. Reinf. lever presses	0.6	0.9	1.5	0.3	-1.1	-1.2	0.8
Condit. Reinf. lever reinforcers received	1.1	1.5	2.4	-1.6	0.8	0.9	-1.5
Conditioned reinforcement - actives	0.3	1.1	2.0	1.2	-1.4	-0.6	0.9
Conditioned reinforcement - inactives	0.5	1.5	5.7	2.4	-0.1	0.2	0.2
Conditioned locomotion	0.6	0.9	2.0	1.1	-1.4	-0.4	0.6
Patch foraging indifference point 0 sec	0.6	1.8	5.9	-2.4	-0.4	0.2	-1.1
Patch foraging indifference point AUC	0.3	0.8	1.8	1.0	-1.3	-0.7	0.2
Delay disc. indifference point, 0s delay	2.4	2.8	4.1	-1.6	1.4	2.0	-1.6
Delay disc. indifference point, 16s delay	1.4	1.9	7.1	2.7	0.5	-0.1	0.6
Delay disc. indifference point, 2s delay	0.3	0.3	0.8	-0.1	0.9	0.8	0.0
Delay disc. indifference point, 24s delay	2.0	3.1	9.9	3.1	-1.0	-0.6	1.1
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.1	-0.3	-0.3
Delay disc. indifference point, 8s delay	0.3	0.5	1.0	-0.2	0.9	1.0	-0.2
Indifference point function ln k	0.0	0.1	0.3	-0.0	0.6	0.0	0.1
Indifference point function log k	0.0	0.1	0.3	-0.0	0.6	0.0	0.1
Patch foraging total patch changes 0 sec	0.4	1.3	4.1	-2.0	-0.8	-0.0	-0.7
Patch foraging total patch changes 12 sec	0.5	0.7	1.7	-1.0	-0.3	-0.1	-1.3
Patch foraging total patch changes 18 sec	0.6	1.4	3.8	-0.4	-1.9	-1.2	0.2
Patch foraging total patch changes 24 sec	0.1	0.4	1.0	-0.3	-0.5	-0.5	-1.0
Patch foraging total patch changes 6 sec	0.5	0.9	1.8	-1.3	-0.9	0.0	-1.0
Patch foraging time to switch 0 sec	0.4	1.5	4.2	-0.3	2.0	0.9	-1.0
Patch foraging water rate 0 sec	0.4	1.6	4.0	0.8	-2.0	-1.0	0.8
Patch foraging water rate 12 sec	0.1	0.2	0.6	-0.2	-0.8	-0.4	0.4
Patch foraging water rate 18 sec	0.4	0.9	1.3	0.6	-1.1	-0.9	1.1
Patch foraging water rate 24 sec	0.5	0.7	1.5	0.4	-1.2	-0.9	0.7
Patch foraging water rate 6 sec	2.1	3.0	4.2	2.1	-1.6	-1.9	1.4
Seeking ratio, delayed vs. immediate footshock	6.1	8.7	21.5	-4.6	1.7	2.2	-2.4
Distance traveled before self-admin	0.2	0.5	0.9	-0.6	-0.8	-0.0	1.0
Distance traveled after self-admin	0.2	0.3	0.6	-0.5	0.6	0.8	-0.2
Extensor digitorum longus weight	3.2	12.7	14.6	3.5	-3.4	-3.8	3.4
Bone: elastic displacement	1.2	1.5	2.9	-1.7	1.0	1.0	-1.1
Bone: elastic work	0.3	0.3	1.2	-1.1	-0.1	0.4	-0.2
Bone: endosteal estimation	0.0	0.1	0.2	-0.4	-0.0	0.4	-0.4
Bone: endosteal perimeter	0.1	0.1	0.4	-0.6	-0.3	-0.2	0.2
Epididymis fat weight	0.1	0.7	1.4	0.9	1.2	0.1	-0.7
Delta time in closed arm before/after self-admin	0.6	0.6	1.4	-1.2	-0.7	-0.6	0.3
Delta time in open arm before/after self-admin	0.6	0.7	0.9	1.0	0.9	0.3	-0.8
Diff in mean of infusions in LGA sessions	0.6	1.0	1.6	-1.3	1.1	0.7	-0.9
Delay discount exponential model param	0.2	0.3	0.6	-0.8	-0.6	-0.4	-0.1
Extinction: sum of active levers before priming	1.6	2.5	7.0	-2.7	0.7	0.9	-1.3
Active lever presses in extinction session 6	0.2	0.2	0.7	0.3	-0.1	-0.8	-0.1
Bone: final force	0.4	0.7	1.1	-0.0	-1.0	-0.9	0.9
Bone: final moment	0.5	0.8	1.3	-0.2	-1.1	-0.9	0.9
Food consumed during 24 hour testing period	2.3	4.7	5.7	-2.1	2.1	2.1	-2.4
Glucose	0.5	0.9	1.2	-1.0	0.7	1.1	-0.9
Heart weight	0.8	1.4	2.5	0.0	-1.6	-1.3	1.2
Delay discount hyperbolic model param	0.1	0.2	0.3	-0.4	-0.5	-0.4	0.0
Intermittent access intake day 1-15 change	0.3	1.6	2.6	0.3	-1.3	-1.5	1.6
Intermittent access intake escalation	0.3	1.8	2.8	0.2	-1.4	-1.6	1.7
Intermittent access intake escalation 2	1.0	1.6	6.0	-2.4	-0.5	-0.1	0.4
Intermitt. access day 1 inactive lever presses	0.0	0.2	0.7	0.2	-0.3	-0.3	0.9
Intermitt. access day 15 inactive lever presses	0.3	1.7	2.4	0.8	-1.2	-1.5	1.6
Intermitt. access escalation Index	0.2	0.6	1.1	-1.0	0.6	0.1	-1.0
Intermittent access day 1 total infusions	0.5	1.6	3.9	2.0	-1.3	-0.8	0.5
Intermittent access day 15 total infusions	1.1	2.7	4.4	2.1	-1.6	-1.7	1.0
Intermittent access terminal intake (last 3 days)	1.3	2.2	4.0	2.0	-1.6	-1.3	0.9
Intermittent access total infusions	3.7	4.4	9.1	3.0	-1.9	-1.7	1.3
Intermittent access day 1 locomotion	0.2	0.4	1.1	0.6	0.1	0.5	-1.1
Intermittent access day 15 total locomotion	0.1	0.2	0.6	0.4	-0.8	-0.2	0.4
Intermittent access total locomotion	1.6	1.9	3.9	2.0	-1.4	-1.0	0.9
Intermittent access standard deviation	0.0	0.1	0.2	0.3	-0.0	-0.3	0.4
Left kidney weight	1.5	11.7	17.3	2.7	-4.2	-3.7	2.9
Right kidney weight	1.9	13.0	17.0	3.3	-4.1	-3.8	3.1
Cocaine induced anxiety	0.3	0.8	2.7	1.7	0.4	-0.3	0.2
Post-drug Anxiety	0.4	0.5	1.5	1.2	0.3	-0.4	-0.3
Baseline Anxiety	0.8	1.3	4.9	-2.2	-0.0	0.4	-0.4
Tail length	0.3	1.6	2.9	-0.3	-1.3	-1.3	1.7
Length with tail	0.7	3.2	4.3	1.4	-1.6	-2.1	2.0
Length without tail	1.1	5.8	10.0	3.2	-1.9	-2.5	1.8
Times rat made contact with spout	0.2	0.2	0.5	0.5	-0.2	-0.5	0.7
Lifetime Intake	2.8	3.5	7.6	2.8	-1.7	-1.4	1.1
Liver weight, left	0.2	0.4	1.0	0.3	-1.0	-0.6	0.4
Liver weight, right	0.6	1.0	2.2	0.7	-1.5	-1.0	0.6
Locomotor activity	0.4	0.6	1.3	-0.2	-0.9	-1.2	0.6
Locomotor testing distance	0.1	0.3	0.7	0.3	-0.5	-0.8	0.4
Locomotor testing rearing	1.1	3.9	6.7	0.8	-2.6	-2.1	2.0
Locomotion in novel chamber	0.4	0.5	1.3	-1.1	0.6	0.6	-0.4
Locomotion in novel chamber post-restriction	0.1	0.4	0.9	-0.9	0.8	-0.1	0.2
Fecal boli incidents, locomotor time 1	0.3	0.7	2.3	-0.2	-0.5	-0.7	1.5
Change in fecal boli incidents, locomotor task	1.4	1.5	4.4	-2.1	0.3	0.5	-1.1
Time >=10cm from walls, locomotor time 1	0.2	0.3	0.7	0.8	-0.5	-0.3	0.3
Bouts of movement, locomotor time 1	0.9	1.2	1.8	-1.4	0.8	1.3	-0.8
Total resting periods, locomotor time 1	0.9	1.0	1.6	-1.3	0.9	1.1	-0.6
Rest time, locomotor task time 1	0.2	0.2	0.6	-0.7	0.4	0.5	-0.1
Distance moved, locomotor task time 1	0.2	0.4	1.2	0.3	0.4	0.6	-1.1
Vertical activity count, locomotor time 1	0.3	1.8	4.3	-2.1	0.6	1.0	-1.3
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.4	-0.3	0.3	0.7	-0.6
Bouts of movement, locomotor time 2	0.5	1.8	3.8	-1.2	2.0	1.1	-0.7
Total resting periods, locomotor time 2	0.5	1.9	3.9	-1.2	2.0	1.2	-0.8
Rest time, locomotor task time 2	0.3	0.4	0.8	-0.9	0.5	0.8	0.1
Distance moved, locomotor task time 2	0.3	0.4	1.4	0.4	-0.2	0.2	-1.2
Vertical activity count, locomotor time 2	0.1	0.2	0.5	0.6	0.2	0.1	-0.7
Light reinforcement 1	0.0	0.2	0.7	0.8	-0.2	0.3	-0.2
Light reinforcement 2	0.0	0.1	0.2	0.4	-0.3	-0.2	0.2
Bone: marrow area	0.0	0.1	0.2	-0.4	-0.0	0.4	-0.4
Bone: maximum diameter	1.3	2.6	4.0	0.5	-2.0	-1.9	1.6
Bone: maximum force	0.2	0.4	0.8	-0.2	-0.9	-0.6	0.6
Bone: maximum moment	0.3	0.5	0.9	-0.3	-1.0	-0.7	0.7
Mean time between licks in bursts	0.0	0.2	0.8	-0.9	0.2	0.1	-0.1
Mean num. licks in bursts	0.7	2.0	2.9	-1.3	1.3	1.7	-1.2
Cd content in liver	0.7	0.8	1.3	0.6	-0.7	-1.1	1.0
Co content in liver	1.1	1.3	1.5	-1.2	1.2	1.1	-1.0
Cu content in liver	1.3	1.5	2.7	1.3	-0.6	-1.2	1.6
Fe content in liver	2.2	2.7	4.0	2.0	-1.8	-1.6	1.1
K content in liver	0.8	0.8	1.9	-1.4	0.6	0.7	-0.6
Mg content in liver	0.0	0.0	0.0	-0.2	0.2	0.0	0.1
Mn content in liver	1.1	1.3	1.8	-1.0	0.7	1.3	-1.4
Na content in liver	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.1
Rb content in liver	0.1	0.1	0.2	0.5	-0.3	-0.4	0.1
Se content in liver	0.2	0.3	0.6	0.2	-0.8	-0.4	0.4
Sr content in liver	0.7	0.6	1.5	-1.2	0.2	0.8	-0.6
Zn content in liver	0.6	0.7	1.0	0.8	-0.7	-0.8	1.0
Bone: minimum diameter	0.4	0.7	1.2	0.2	-1.0	-1.1	0.9
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.8	-0.6	-0.3	-0.1
Time in novel zone, hab. session 1	0.8	0.9	1.3	1.1	-0.7	-1.0	0.9
Total zone transitions, hab. session 1	0.4	0.6	1.1	0.3	-1.0	-1.0	0.6
Total locomotion distance, hab. session 1	0.1	0.2	0.7	-0.8	0.1	-0.1	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.6	-0.7	0.5	0.2	0.1
Time in familiar zone, hab. session 2	1.4	1.5	1.8	1.0	-1.3	-1.3	1.3
Time in novel zone, hab. session 2	0.0	0.0	0.0	-0.0	0.2	-0.0	-0.0
Total zone transitions, hab. session 2	0.1	0.2	0.3	-0.5	-0.6	-0.3	0.1
Total locomotion distance, hab. session 2	0.1	0.2	0.3	-0.6	0.5	0.3	-0.1
Locomotion velocity, hab. session 2	0.2	0.2	0.6	-0.8	0.4	0.3	-0.3
Novel to familiar place preference ratio	0.9	1.2	1.9	0.7	-1.4	-1.1	1.0
Novelty place preference	0.8	1.0	1.5	0.8	-1.2	-1.1	0.8
Time in novel zone, NPP test	1.3	1.5	2.2	1.1	-1.5	-1.3	1.1
Total zone transitions, NPP test	0.1	0.1	0.3	-0.0	-0.5	-0.5	0.3
Total locomotion distance, NPP test	0.9	1.3	1.9	0.7	-1.1	-1.4	1.3
Locomotion velocity, NPP test	0.5	0.7	1.2	0.3	-0.8	-1.1	1.0
Intraocular pressure	0.8	1.4	1.6	1.3	-1.0	-1.3	1.1
Delta distance traveled before/after self-admin	1.1	1.2	2.5	0.1	1.6	0.9	-1.2
Delta ambulatory time before/after self-admin	0.3	0.6	1.2	-0.0	1.1	0.5	-0.9
Parametrial fat weight	0.3	0.8	3.0	-1.7	-0.3	-0.2	0.4
Pavlov. Cond. lever latency	0.6	0.7	1.0	1.0	-0.4	-1.0	0.9
Pavlov. Cond. magazine entry latency	0.3	0.4	0.6	-0.0	-0.8	-0.7	0.6
Pavlov. Cond. change in total contacts	1.9	2.0	2.8	-1.7	1.2	1.4	-1.4
Pavlov. Cond. index score	0.3	0.4	0.9	-1.0	0.1	0.5	-0.5
Pavlov. Cond. latency score	0.8	1.0	2.0	-1.4	0.5	0.9	-1.0
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.7	0.3	0.7	-0.6
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	0.5	0.3	0.4	-0.1
Pavlov. Cond. intertrial magazine entries	0.2	0.3	0.6	-0.5	0.2	0.8	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.6	-0.8	0.1	0.5	-0.4
Pavlov. Cond. response bias	0.3	0.4	0.7	0.3	-0.8	-0.6	0.6
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.9	0.4	0.6	0.0
Pavlov. Cond. magazine entry latency	2.1	2.9	3.7	1.5	-1.9	-1.8	1.5
Pavlov. Cond. change in total contacts	0.2	0.4	1.0	-0.2	-0.6	-1.0	0.6
Pavlov. Cond. index score	0.9	1.4	2.3	0.6	-1.3	-1.5	1.1
Pavlov. Cond. latency score	0.7	1.0	1.9	0.5	-1.1	-1.4	0.9
Pavlov. Cond. lever contacts	0.4	0.5	1.0	-0.5	-0.8	-1.0	0.4
Pavlov. Cond. magazine entry number	1.9	2.5	2.9	-1.5	1.6	1.7	-1.5
Pavlov. Cond. intertrial magazine entries	1.0	2.3	3.2	-1.0	1.6	1.8	-1.6
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.6	2.4	0.8	-1.4	-1.5	1.2
Pavlov. Cond. response bias	0.3	0.5	0.9	-0.1	-0.9	-1.0	0.5
Time in closed arm before self-admin	0.6	1.0	2.1	1.4	-1.1	-0.3	0.7
Time in closed arm after self-admin	1.8	2.1	6.9	2.6	-0.3	-0.9	0.7
Time in open arm before self-admin	4.2	5.1	19.7	-4.4	0.5	0.5	0.4
Time in open arm after self-admin	4.0	4.4	11.5	-3.4	1.6	1.2	-1.5
Bone: periosteal estimation	0.2	0.5	0.9	0.1	-0.9	-0.8	0.7
Bone: periosteal perimeter	0.3	0.6	0.8	-0.0	-0.9	-0.9	0.9
Bone: post-yield work	0.1	0.2	0.3	-0.3	0.6	0.5	-0.5
Progressive ratio test 1 active lever presses	0.2	0.4	1.0	0.9	-1.0	0.1	-0.0
Progressive ratio test 1 breakpoint	0.2	0.3	0.8	0.6	-0.9	0.2	-0.2
Progressive ratio test 1 inactive lever presses	1.7	4.4	13.6	3.7	-1.3	-0.8	1.3
Progressive ratio test 2 active lever presses	2.9	4.1	8.6	2.9	-1.7	-1.6	1.5
Progressive ratio test 2 breakpoint	3.6	4.7	10.1	3.2	-1.8	-1.7	1.6
Progressive ratio test 2 inactive lever presses	0.3	1.0	2.6	1.6	-0.8	-0.8	0.5
Incentive Sensitization - Responses	2.9	8.0	18.6	4.3	-1.8	-2.3	2.2
Incentive Sensitization - Breakpoint	3.5	8.0	19.1	4.4	-1.7	-2.4	2.1
Sum of active levers in priming session hrs 5-6	2.0	1.9	2.6	1.0	1.5	1.2	-1.6
Progressive ratio	0.1	0.3	0.5	0.5	0.7	0.7	-0.4
Food seeking constrained by brief footshock	13.2	16.4	31.5	-5.6	3.0	3.7	-3.5
Seeking ratio, punishment vs. effort	1.6	3.6	8.1	-2.8	1.4	1.3	-1.6
Retroperitoneal fat weight	0.1	0.6	0.8	0.9	-0.5	-0.9	0.8
Reaction time number correct	1.9	6.6	9.8	1.5	-3.1	-2.3	3.0
Reaction time mean minus median	0.0	0.1	0.3	0.5	-0.2	0.3	-0.0
Reaction time mean minus median AUC	0.2	1.3	3.0	1.7	-1.0	-0.6	1.0
Reaction time num false alarms	1.7	2.9	6.6	0.7	-2.6	-1.5	1.5
Reaction time num false alarms AUC	0.9	2.1	5.5	0.2	-2.3	-1.1	1.4
Reaction time trials correct on left	1.9	6.6	9.8	1.5	-3.1	-2.3	3.0
Reaction time trials on left	1.9	6.6	9.8	1.5	-3.1	-2.3	3.0
Reaction time mean	0.2	0.5	0.6	0.6	0.8	0.7	-0.8
Reaction time mean AUC	0.2	0.5	0.7	0.3	0.7	0.9	-0.8
Median of all reaction times	0.5	0.7	1.2	0.4	1.1	0.8	-1.0
Reaction time omissions	0.0	0.0	0.0	0.2	-0.1	-0.1	0.2
Reaction time false alarm rate	0.2	0.2	0.5	-0.7	-0.3	0.3	-0.4
Reaction time premature initiation rate	0.5	0.7	1.3	0.5	1.2	0.5	-1.0
Reaction time premature initiations	0.2	0.7	1.8	1.3	-0.5	-0.7	0.7
Std. dev. reaction times	0.1	0.2	0.3	0.6	0.2	0.6	-0.4
Reaction time trials completed	1.9	6.6	9.8	1.5	-3.1	-2.3	3.0
Reaction time trials AUC	2.2	7.5	11.3	1.7	-3.4	-2.5	3.1
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.5	0.2	-0.1	0.4
Run reversals in cocaine runway, males	0.3	0.3	0.7	0.8	-0.3	-0.4	0.5
Latency to leave start box in cocaine runway	0.9	1.2	1.6	1.3	-1.1	-1.1	0.9
Latency to leave start box in cocaine runway, F	0.8	1.0	1.3	0.7	-1.1	-1.0	1.1
Latency to leave start box in cocaine runway, M	0.7	0.7	2.3	1.5	-0.4	-0.6	0.0
Std. dev. time between licks in bursts	0.3	0.5	1.7	-1.3	-0.1	0.3	-0.6
Total sessions with >9 infusions	2.4	2.9	8.7	3.0	-1.2	-0.9	0.8
Short access day 1 total inactive lever presses	2.3	4.6	14.9	3.9	-0.5	-1.5	1.0
Short access day 10 total inactive lever presses	0.1	0.4	0.6	0.7	0.8	0.2	0.5
Short access day 1 total infusions	1.2	2.3	7.8	2.8	-0.8	-0.6	0.6
Short access day 10 total infusions	1.6	2.6	5.9	2.4	-1.7	-0.5	1.2
Short access total infusions	1.2	1.8	5.0	2.2	-1.1	-0.4	0.7
Short access day 1 locomotion	2.3	3.8	8.4	2.9	-1.5	-1.5	1.5
Short access day 10 total locomotion	0.1	0.4	1.2	-1.1	0.1	0.7	-0.0
Short access total locomotion	0.1	0.1	0.3	-0.1	-0.1	0.5	-0.5
One hour access (0.3 mA shock)	2.3	2.7	9.5	3.1	-0.3	-1.1	0.1
Compulsive drug intake	0.5	0.7	1.6	1.3	0.5	-0.1	-1.0
One hour access (shock baseline)	1.4	3.8	9.6	3.1	-1.4	-1.5	1.1
Social response proportion	0.5	0.7	1.4	0.9	-1.2	-0.5	0.7
Social responses	0.1	0.1	0.2	0.4	-0.4	0.0	-0.3
Social time	1.3	2.0	2.9	-1.3	1.7	1.3	-1.3
Soleus weight	1.7	5.0	7.2	1.7	-2.0	-2.5	2.7
Bone: stiffness	1.0	1.8	2.3	0.9	-1.5	-1.3	1.5
Tibialis anterior weight	4.5	15.4	16.9	3.4	-4.1	-4.1	4.1
Time to tail flick, vehicle, before self-admin	0.4	0.4	1.0	-1.0	-0.8	0.2	-0.2
Time to tail flick, vehicle, after self-admin	0.7	1.4	2.3	1.5	-1.0	-1.4	0.8
Time to tail flick, test, before self-admin	4.4	5.0	9.7	-3.1	1.6	2.1	-1.9
Time to tail flick, test, after self-admin	0.7	0.8	1.4	-0.9	0.5	1.2	-0.7
Delta time to tail flick, vehicle, before/after SA	0.6	0.7	1.3	1.1	-0.5	-0.7	0.8
Delta time to tail flick, test, before/after SA	1.2	1.4	1.9	1.4	-1.3	-0.9	1.2
Tibia length	0.1	0.2	0.5	0.7	-0.3	0.2	-0.1
Ambulatory time before self-admin	0.1	0.2	0.5	-0.3	-0.4	0.1	0.7
Ambulatory time after self-admin	0.3	0.5	0.8	-0.3	0.8	0.9	-0.7
Bone: tissue strength	2.0	2.1	5.7	-2.4	0.8	1.2	-0.9
Total heroin consumption	0.5	0.6	1.1	-0.8	0.4	1.0	-0.8
Bone: trabecular number	0.1	0.1	0.3	-0.6	0.1	0.2	-0.3
Bone: trabecular spacing	0.0	0.1	0.1	-0.2	-0.2	-0.3	0.3
Bone: trabecular thickness	0.9	1.3	1.6	1.0	-1.3	-1.2	1.2
Bone: trabecular tissue density	2.2	3.8	6.7	2.6	-1.2	-1.6	2.1
Water consumed over 24 hours	0.5	0.9	1.5	-0.5	0.8	1.1	-1.2
Number of responses in last shaping day	4.1	5.3	14.3	3.8	-1.7	-1.6	1.2