Hub : Genes

LOC120096585

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr14_20404477_20405784	0.81	0.02	0.0e+00	0.44	0.41	0.45	0.46	8.6e-53	1.4e-49	7.7e-56	5.0e-56
2	Liver	intron excision ratio	chr14_20405906_20406423	0.73	0.07	0.0e+00	0.28	0.28	0.3	0.3	3.5e-31	1.4e-30	1.7e-33	4.0e-33
3	Liver	intron excision ratio	chr14_20402624_20404330	0.8	0.03	0.0e+00	0.43	0.42	0.44	0.44	2.5e-51	8.6e-50	8.9e-54	4.2e-54
4	Liver	intron excision ratio	chr14_20402624_20406423	0.78	0.03	0.0e+00	0.41	0.42	0.43	0.43	7.9e-49	1.3e-49	2.7e-51	2.4e-51
5	Liver	intron excision ratio	chr14_20402664_20406423	0.85	0.02	0.0e+00	0.39	0.44	0.46	0.46	5.4e-46	4.3e-53	1.6e-56	3.8e-57
6	Liver	mRNA stability	LOC120096585	0.68	0.11	0.0e+00	0.24	0.25	0.26	0.26	8.0e-27	1.3e-27	3.2e-29	2.9e-29
7	Liver	intron excision ratio	chr14_20402664_20404330	0.78	0.04	0.0e+00	0.42	0.43	0.42	0.42	4.8e-50	2.7e-51	5.5e-51	8.2e-51
8	Liver	gene expression	LOC120096585	0.85	0.02	0.0e+00	0.54	0.59	0.62	0.62	1.1e-71	1.0e-80	6.1e-87	6.8e-87
9	Adipose	gene expression	LOC120096585	0.04	0.03	4.8e-05	0.04	0.03	0.04	0.04	1.2e-05	4.9e-04	4.3e-05	2.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.1	0.2	0.4	0.4	-0.4	0.4	-0.4	-0.5	-0.4	0.7	0.6	0.6
Area under the delay curve	0.0	0.0	0.1	0.3	-0.2	0.2	0.0	-0.2	0.2	0.1	0.1	0.2
BMI with tail	1.4	4.5	5.6	2.0	-2.4	2.1	-2.1	-2.2	-2.0	2.2	2.4	1.9
BMI without tail	0.0	0.0	0.2	-0.1	-0.2	-0.1	0.1	0.1	0.2	0.3	0.1	-0.5
Body weight	0.0	0.0	0.2	-0.1	-0.2	-0.1	0.0	-0.1	0.1	0.3	0.4	0.3
Weight adjusted by age	0.9	1.0	2.0	0.9	-0.7	0.9	-1.0	-1.0	-1.1	0.9	1.1	1.4
Bone surface	0.0	0.1	0.2	-0.3	0.5	-0.3	0.2	0.2	0.1	0.1	-0.1	0.1
Bone volume	0.2	0.4	0.6	-0.7	0.8	-0.7	0.7	0.6	0.6	-0.4	-0.5	-0.4
Breakpoint value in progressive ratio session	0.2	0.2	0.3	-0.5	0.4	-0.5	0.5	0.4	0.5	-0.6	-0.4	-0.4
Number of licking bursts	0.1	0.1	0.3	0.2	-0.1	0.1	-0.2	-0.2	-0.1	0.5	0.3	0.2
Context. condit. distance diff. score	0.3	0.4	1.0	-0.5	0.9	-0.4	0.3	0.6	0.4	-1.0	-0.7	-0.7
Locomotion velocity, session 1	0.8	0.8	1.1	0.8	-1.0	0.8	-0.7	-0.9	-0.8	1.0	1.0	1.1
Locomotion distance, session 1	0.3	0.4	0.5	-0.7	0.7	-0.6	0.6	0.7	0.6	-0.7	-0.5	-0.3
Locomotion velocity, session 2	0.2	0.2	0.3	-0.4	0.5	-0.4	0.4	0.5	0.4	-0.5	-0.5	-0.3
Locomotion distance, session 2	0.2	0.3	0.4	-0.6	0.6	-0.7	0.6	0.6	0.6	-0.5	-0.5	-0.4
Locomotion velocity, session 3	0.2	0.2	0.4	-0.4	0.5	-0.3	0.5	0.5	0.5	-0.6	-0.6	-0.2
Locomotion distance, session 3	0.2	0.3	0.5	0.6	-0.5	0.7	-0.6	-0.5	-0.6	0.3	0.3	0.4
Stereotopy head waving bouts, day 3	0.3	0.3	0.7	0.5	-0.6	0.4	-0.4	-0.6	-0.4	0.6	0.7	0.8
Stereotopy head waving duration, day 3	0.1	0.1	0.3	-0.4	0.3	-0.4	0.5	0.2	0.4	-0.2	0.0	0.3
Locomotion velocity, session 7	2.1	2.3	2.7	-1.5	1.4	-1.5	1.6	1.5	1.6	-1.4	-1.5	-1.6
Locomotion distance, session 7	1.5	1.9	2.7	-1.4	1.4	-1.3	1.3	1.4	1.4	-1.4	-1.3	-1.6
Stereotopy head waving bouts, day 7	0.2	0.2	0.5	0.5	-0.4	0.4	-0.4	-0.5	-0.5	0.5	0.5	0.7
Stereotopy head waving duration, day 7	0.4	0.4	0.7	0.6	-0.7	0.6	-0.5	-0.7	-0.6	0.6	0.7	0.9
Locomotion velocity, session 8	0.0	0.1	0.3	-0.1	0.3	-0.1	0.1	0.2	0.1	-0.6	-0.2	0.1
Locomotion distance, session 8	1.4	2.1	3.1	-1.4	1.8	-1.4	1.3	1.4	1.3	-1.7	-1.3	-1.2
Degree of sensitization distance	3.0	3.0	4.1	-1.8	1.8	-1.8	1.7	1.7	1.7	-1.6	-1.5	-2.0
Degree of sensitization stereotypy	0.2	0.3	0.4	0.6	-0.5	0.6	-0.6	-0.5	-0.6	0.5	0.4	0.4
Conditioned locomotion	0.7	0.8	1.2	1.0	-0.9	1.1	-1.1	-0.9	-0.9	0.7	0.8	0.4
Cocaine response after cond. corrected	0.4	0.4	0.5	-0.6	0.6	-0.6	0.6	0.7	0.6	-0.7	-0.7	-0.7
Cocaine response after cond. not corrected	0.5	0.5	0.7	-0.7	0.8	-0.7	0.7	0.8	0.6	-0.7	-0.8	-0.7
Cocaine response before conditioning	0.0	0.0	0.1	0.2	-0.1	0.1	-0.2	-0.2	-0.3	0.3	0.2	0.2
Saline control response	0.7	1.0	1.3	-0.9	1.0	-0.9	0.9	1.0	0.9	-1.0	-1.0	-1.2
Bone: connectivity density	0.6	0.9	1.4	0.9	-0.9	0.8	-0.8	-0.9	-0.9	1.2	1.0	1.0
Bone: cortical apparent density	0.2	0.2	0.6	0.4	-0.8	0.4	-0.1	-0.4	-0.3	0.4	0.4	0.5
Bone: cortical area	0.7	1.1	1.7	-1.0	1.0	-1.1	1.1	1.0	1.1	-0.7	-1.0	-1.3
Bone: cortical porosity	2.2	2.4	2.9	1.6	-1.4	1.6	-1.6	-1.5	-1.7	1.5	1.5	1.4
Bone: cortical porosity	2.9	3.1	3.5	1.8	-1.7	1.8	-1.8	-1.8	-1.9	1.8	1.8	1.6
Bone: cortical thickness	0.2	0.4	0.8	0.7	-0.7	0.5	-0.6	-0.6	-0.5	0.9	0.7	0.2
Bone: cortical thickness	0.0	0.0	0.1	0.2	0.0	0.2	-0.2	-0.1	-0.1	0.2	-0.3	-0.1
Bone: cortical tissue density	0.3	0.4	0.9	0.5	-0.9	0.6	-0.3	-0.6	-0.4	0.5	0.5	0.7
Condit. Reinf. active minus inactive responses	0.9	1.0	1.2	1.0	-1.1	1.0	-1.1	-0.9	-1.0	1.1	0.9	0.7
Condit. Reinf. active-inactive response ratio	3.0	3.3	3.6	1.8	-1.8	1.8	-1.9	-1.8	-1.8	1.9	1.8	1.7
Condit. Reinf. active responses	0.0	0.0	0.1	-0.0	-0.1	-0.1	-0.0	0.1	0.1	0.2	-0.0	-0.2
Condit. Reinf. inactive responses	1.9	2.2	3.1	-1.4	1.4	-1.5	1.4	1.5	1.5	-1.3	-1.5	-1.8
Incentive salience index mean	0.1	0.1	0.2	0.3	-0.4	0.3	-0.4	-0.3	-0.3	0.3	0.3	0.2
Condit. Reinf. lever presses	0.0	0.0	0.0	0.0	-0.0	0.0	-0.0	-0.0	0.0	0.0	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.2	0.3	-0.5	0.5	-0.6	0.6	0.5	0.5	-0.4	-0.2	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.1	-0.2	0.2	-0.3	0.3	0.3	0.3	-0.1	-0.2	-0.1
Condit. Reinf. active responses	0.4	0.5	0.8	-0.8	0.9	-0.9	0.9	0.7	0.7	-0.7	-0.5	0.1
Condit. Reinf. inactive responses	1.0	1.2	1.9	-1.2	1.4	-1.2	1.2	1.0	1.1	-1.2	-0.9	-0.4
Condit. Reinf. lever presses	0.4	0.5	0.8	-0.6	0.9	-0.7	0.6	0.8	0.6	-0.7	-0.7	-0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	1.1	-0.9	1.0	-0.9	0.9	0.8	0.7	-0.8	-0.5	0.1
Conditioned reinforcement - actives	0.0	0.0	0.2	0.2	-0.1	0.3	-0.4	-0.2	-0.3	0.0	0.1	-0.1
Conditioned reinforcement - inactives	0.4	0.4	0.8	-0.5	0.6	-0.4	0.5	0.6	0.5	-0.8	-0.9	-0.8
Conditioned locomotion	0.1	0.1	0.2	-0.2	0.3	-0.3	0.1	0.3	0.2	-0.2	-0.4	-0.5
Patch foraging indifference point 0 sec	0.2	0.4	0.6	-0.6	0.6	-0.5	0.8	0.6	0.6	-0.8	-0.5	-0.1
Patch foraging indifference point AUC	2.4	2.8	3.2	-1.8	1.5	-1.7	1.7	1.6	1.8	-1.5	-1.6	-1.8
Delay disc. indifference point, 0s delay	0.2	0.2	0.3	0.6	-0.5	0.5	-0.3	-0.4	-0.2	0.5	0.3	0.3
Delay disc. indifference point, 16s delay	0.7	0.7	1.2	1.0	-1.1	0.9	-0.7	-1.0	-0.5	0.8	0.8	0.7
Delay disc. indifference point, 2s delay	3.6	4.0	5.0	-2.0	2.0	-2.0	2.1	2.0	2.2	-1.9	-2.0	-1.7
Delay disc. indifference point, 24s delay	0.0	0.0	0.3	-0.0	0.1	-0.0	0.1	-0.1	0.1	-0.2	0.1	0.5
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.1	-0.2	0.1	0.2	-0.0	0.3	-0.0	-0.4	-0.3
Delay disc. indifference point, 8s delay	1.1	1.2	1.4	1.2	-1.2	1.0	-1.0	-1.2	-0.8	1.1	1.2	1.2
Indifference point function ln k	0.8	1.1	1.5	1.1	-0.9	1.1	-1.1	-1.0	-1.1	0.9	1.0	1.2
Indifference point function log k	0.8	1.1	1.5	1.1	-0.9	1.1	-1.1	-1.0	-1.1	0.9	1.0	1.2
Patch foraging total patch changes 0 sec	0.2	0.3	0.6	-0.6	0.6	-0.5	0.8	0.6	0.6	-0.8	-0.6	-0.1
Patch foraging total patch changes 12 sec	0.8	1.0	1.4	-1.1	0.9	-1.1	1.1	1.0	1.2	-1.0	-0.7	-1.0
Patch foraging total patch changes 18 sec	0.0	0.0	0.1	0.1	-0.2	0.1	-0.0	-0.2	-0.1	0.2	0.0	0.3
Patch foraging total patch changes 24 sec	0.7	0.9	1.1	-1.0	1.0	-0.9	1.0	0.9	1.0	-1.0	-0.8	-0.7
Patch foraging total patch changes 6 sec	1.4	2.1	2.4	-1.5	1.4	-1.5	1.6	1.4	1.5	-1.5	-1.4	-1.4
Patch foraging time to switch 0 sec	3.4	5.2	5.6	2.3	-2.3	2.3	-2.2	-2.4	-2.3	2.1	2.3	2.2
Patch foraging water rate 0 sec	2.7	4.3	4.7	-2.2	2.1	-2.2	2.1	2.2	2.2	-1.8	-2.0	-2.1
Patch foraging water rate 12 sec	0.4	0.6	1.3	-0.7	0.8	-0.7	0.6	0.8	0.7	-0.6	-1.0	-1.2
Patch foraging water rate 18 sec	2.2	3.0	3.5	-1.6	1.8	-1.6	1.7	1.8	1.7	-1.7	-1.9	-1.8
Patch foraging water rate 24 sec	1.6	2.2	3.2	-1.3	1.7	-1.4	1.2	1.5	1.4	-1.3	-1.6	-1.8
Patch foraging water rate 6 sec	0.9	1.3	2.0	-1.1	1.1	-1.2	1.1	1.2	1.2	-0.9	-1.1	-1.4
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.7	-0.6	0.7	-0.6	0.7	0.6	0.6	-0.7	-0.8	-0.8
Distance traveled before self-admin	0.7	0.7	1.0	-1.0	1.0	-0.9	0.9	0.9	0.8	-0.9	-0.7	-0.4
Distance traveled after self-admin	3.0	3.4	4.4	-1.9	2.1	-1.9	1.8	1.9	1.7	-1.9	-1.9	-1.3
Extensor digitorum longus weight	12.1	47.4	49.9	7.0	-6.9	6.9	-7.0	-7.0	-6.9	7.1	7.0	6.3
Bone: elastic displacement	0.8	0.9	1.4	1.2	-0.9	1.1	-1.1	-0.9	-1.0	0.9	0.8	0.8
Bone: elastic work	1.1	1.4	2.3	1.5	-1.1	1.4	-1.3	-1.2	-1.3	1.2	0.8	0.8
Bone: endosteal estimation	2.9	6.4	7.5	-2.6	2.7	-2.6	2.6	2.6	2.4	-2.7	-2.5	-2.1
Bone: endosteal perimeter	0.8	1.7	2.1	-1.3	1.4	-1.4	1.3	1.3	1.2	-1.1	-1.3	-1.1
Epididymis fat weight	0.1	0.2	0.3	-0.6	0.4	-0.5	0.4	0.4	0.5	-0.3	-0.2	-0.2
Delta time in closed arm before/after self-admin	1.3	1.2	1.8	1.2	-1.3	1.1	-1.3	-1.1	-1.1	1.2	1.0	0.3
Delta time in open arm before/after self-admin	1.1	1.0	1.6	-1.2	1.1	-1.1	1.3	1.0	1.1	-1.0	-0.9	-0.3
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.2	-0.1	0.2	-0.1	-0.2	-0.1	-0.2	0.2	0.4
Delay discount exponential model param	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.2	0.1	-0.3	0.1	0.1	-0.1
Extinction: sum of active levers before priming	0.0	0.0	0.1	-0.2	0.3	-0.1	0.2	0.2	0.2	-0.2	-0.3	-0.0
Active lever presses in extinction session 6	0.8	0.8	1.0	-1.0	0.9	-0.9	0.9	0.9	1.0	-0.9	-0.8	-0.8
Bone: final force	0.4	0.7	0.9	-0.9	0.9	-0.9	0.9	0.8	0.8	-0.5	-0.8	-0.8
Bone: final moment	0.3	0.6	0.9	-0.7	0.7	-0.8	0.7	0.8	0.7	-0.4	-0.8	-0.9
Food consumed during 24 hour testing period	2.0	2.4	3.1	-1.6	1.8	-1.5	1.4	1.7	1.5	-1.5	-1.5	-1.6
Glucose	1.5	2.2	2.6	-1.5	1.5	-1.5	1.5	1.5	1.5	-1.6	-1.4	-1.3
Heart weight	0.0	0.0	0.1	-0.2	0.1	-0.3	0.1	0.2	0.1	0.1	0.2	-0.2
Delay discount hyperbolic model param	0.1	0.1	0.4	0.2	-0.2	0.3	-0.5	-0.2	-0.6	0.4	0.4	0.2
Intermittent access intake day 1-15 change	0.6	0.5	1.0	0.7	-0.5	0.7	-1.0	-0.7	-0.8	0.8	0.9	0.3
Intermittent access intake escalation	0.2	0.2	0.4	0.3	-0.1	0.3	-0.6	-0.3	-0.5	0.3	0.6	0.0
Intermittent access intake escalation 2	0.3	0.3	0.5	-0.6	0.7	-0.6	0.4	0.6	0.5	-0.6	-0.5	-0.7
Intermitt. access day 1 inactive lever presses	0.5	0.5	1.5	-0.7	0.8	-0.5	0.7	0.7	0.6	-1.2	-0.6	-0.4
Intermitt. access day 15 inactive lever presses	1.3	1.5	1.7	-1.2	1.3	-1.1	1.2	1.2	1.2	-1.3	-1.2	-1.0
Intermitt. access escalation Index	2.1	1.8	2.1	1.4	-1.3	1.3	-1.3	-1.4	-1.3	1.4	1.3	1.5
Intermittent access day 1 total infusions	0.0	0.1	0.1	0.3	-0.2	0.3	-0.2	-0.3	-0.2	0.1	-0.0	0.3
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.0	0.2	0.0	-0.1	0.1	-0.0	-0.2	-0.1	-0.3
Intermittent access terminal intake (last 3 days)	0.5	0.5	1.0	-0.7	0.8	-0.6	0.5	0.7	0.6	-0.8	-0.7	-1.0
Intermittent access total infusions	0.0	0.0	0.1	0.0	0.1	0.1	-0.1	0.0	-0.0	-0.1	-0.1	-0.2
Intermittent access day 1 locomotion	0.0	0.0	0.1	0.0	0.0	0.1	-0.0	0.0	0.0	-0.2	-0.3	-0.2
Intermittent access day 15 total locomotion	0.1	0.1	0.2	-0.2	0.3	-0.1	0.1	0.2	0.1	-0.4	-0.5	-0.4
Intermittent access total locomotion	0.0	0.0	0.1	0.3	-0.2	0.2	-0.3	-0.2	-0.2	0.1	-0.0	-0.1
Intermittent access standard deviation	0.5	0.5	0.8	-0.7	0.8	-0.7	0.5	0.7	0.6	-0.7	-0.6	-0.9
Left kidney weight	0.8	2.3	2.8	-1.6	1.6	-1.6	1.4	1.6	1.5	-1.4	-1.4	-1.7
Right kidney weight	1.4	3.9	4.8	-2.1	1.9	-2.2	2.0	2.0	2.1	-1.7	-1.7	-2.0
Cocaine induced anxiety	0.0	0.0	0.2	0.0	-0.1	0.0	-0.0	-0.1	-0.0	0.3	0.2	0.4
Post-drug Anxiety	0.0	0.0	0.1	-0.0	-0.2	0.0	0.0	-0.1	0.1	0.1	-0.0	-0.0
Baseline Anxiety	0.0	0.0	0.1	0.3	-0.2	0.3	-0.2	-0.2	-0.3	-0.0	-0.1	-0.0
Tail length	0.2	0.5	0.7	-0.8	0.8	-0.8	0.7	0.8	0.7	-0.4	-0.8	-0.8
Length with tail	1.3	4.7	5.4	-2.3	2.3	-2.3	2.2	2.2	2.2	-2.0	-2.1	-1.7
Length without tail	0.8	1.7	2.3	-1.4	1.4	-1.4	1.5	1.3	1.3	-1.5	-1.1	-0.7
Times rat made contact with spout	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.1	0.1	0.2	0.1	-0.3	-0.3
Lifetime Intake	0.1	0.2	0.3	0.5	-0.4	0.5	-0.5	-0.4	-0.4	0.3	0.2	0.1
Liver weight, left	1.4	2.3	2.7	-1.5	1.3	-1.5	1.6	1.5	1.7	-1.5	-1.6	-1.5
Liver weight, right	2.4	4.0	4.8	-2.1	1.9	-2.0	2.2	2.0	2.1	-2.0	-2.0	-1.6
Locomotor activity	1.2	1.9	2.7	-1.5	1.6	-1.4	1.2	1.4	1.3	-1.3	-1.2	-1.2
Locomotor testing distance	0.3	0.6	1.2	-0.7	1.1	-0.7	0.6	0.8	0.6	-0.9	-0.7	-0.6
Locomotor testing rearing	0.2	0.3	0.7	-0.6	0.8	-0.5	0.4	0.6	0.4	-0.6	-0.3	-0.4
Locomotion in novel chamber	0.0	0.0	0.1	-0.1	0.0	0.0	0.1	0.0	0.0	0.1	0.1	0.2
Locomotion in novel chamber post-restriction	0.3	0.4	0.6	-0.7	0.5	-0.6	0.8	0.6	0.7	-0.4	-0.8	-0.5
Fecal boli incidents, locomotor time 1	2.4	2.6	3.6	1.8	-1.6	1.7	-1.6	-1.7	-1.6	1.9	1.3	1.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.9	0.0	0.1	0.0	0.0	-0.1	-0.1	0.0	0.3	1.0
Time >=10cm from walls, locomotor time 1	3.5	3.5	4.6	1.8	-1.7	1.9	-1.8	-1.9	-1.8	1.9	1.8	2.1
Bouts of movement, locomotor time 1	0.9	1.0	1.3	0.8	-1.0	0.9	-1.0	-1.0	-1.0	1.1	1.1	1.0
Total resting periods, locomotor time 1	0.9	1.0	1.3	0.8	-1.0	0.9	-0.9	-1.0	-1.0	1.1	1.0	1.1
Rest time, locomotor task time 1	0.1	0.1	0.3	-0.3	0.6	-0.3	0.4	0.2	0.2	-0.1	-0.5	0.3
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.0	-0.1	0.0	-0.0	0.0	0.1	-0.2	0.1	-0.3
Vertical activity count, locomotor time 1	1.0	1.0	1.8	-1.0	0.7	-1.0	1.0	1.0	1.2	-0.9	-0.7	-1.3
Time >=10cm from walls, locomotor time 2	1.0	1.1	3.3	0.9	-0.6	0.9	-0.8	-1.0	-0.9	1.0	1.0	1.8
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.4	0.4	-0.3	0.5	0.3	0.2	-0.5	-0.3	0.3
Total resting periods, locomotor time 2	0.1	0.1	0.2	-0.4	0.3	-0.2	0.4	0.2	0.2	-0.4	-0.2	0.3
Rest time, locomotor task time 2	0.3	0.4	0.9	-0.7	1.0	-0.6	0.6	0.5	0.3	-0.7	-0.5	0.3
Distance moved, locomotor task time 2	0.8	1.0	1.4	1.1	-1.2	1.0	-1.0	-0.9	-0.8	1.2	1.1	0.5
Vertical activity count, locomotor time 2	0.1	0.1	0.4	-0.1	-0.1	-0.2	0.2	0.2	0.4	0.2	0.1	-0.6
Light reinforcement 1	0.9	1.6	1.8	-1.4	1.3	-1.3	1.3	1.2	1.3	-1.2	-1.1	-1.2
Light reinforcement 2	0.2	0.2	0.5	0.4	-0.5	0.4	-0.3	-0.5	-0.4	0.4	0.4	0.7
Bone: marrow area	2.8	6.1	7.3	-2.6	2.7	-2.5	2.5	2.5	2.3	-2.6	-2.4	-2.0
Bone: maximum diameter	0.3	0.5	0.9	-0.8	0.6	-0.9	0.8	0.7	0.8	-0.3	-0.5	-0.8
Bone: maximum force	0.8	1.3	1.5	-1.1	1.2	-1.2	1.2	1.2	1.1	-0.9	-1.2	-1.2
Bone: maximum moment	0.8	1.4	2.0	-1.1	1.1	-1.2	1.1	1.2	1.1	-0.8	-1.3	-1.4
Mean time between licks in bursts	3.8	5.4	5.9	2.3	-2.4	2.2	-2.2	-2.3	-2.4	2.4	2.4	2.3
Mean num. licks in bursts	0.2	0.2	0.6	-0.3	0.2	-0.1	0.3	0.4	0.4	-0.6	-0.7	-0.7
Cd content in liver	2.3	2.5	3.0	1.6	-1.7	1.6	-1.5	-1.6	-1.7	1.5	1.5	1.4
Co content in liver	0.1	0.1	0.1	-0.3	0.3	-0.3	0.4	0.3	0.2	-0.3	-0.3	-0.1
Cu content in liver	1.0	1.2	1.3	-1.1	1.0	-1.1	1.1	1.1	1.1	-1.1	-1.0	-0.9
Fe content in liver	0.3	0.3	0.6	0.5	-0.7	0.4	-0.4	-0.6	-0.5	0.8	0.6	0.7
K content in liver	1.7	1.7	2.3	-1.5	1.2	-1.4	1.5	1.3	1.3	-1.5	-1.0	-0.9
Mg content in liver	1.7	1.7	2.5	-1.6	1.2	-1.5	1.5	1.3	1.3	-1.4	-1.0	-0.9
Mn content in liver	0.2	0.2	0.4	-0.6	0.6	-0.5	0.4	0.4	0.5	-0.5	-0.1	0.0
Na content in liver	0.7	0.7	1.0	-1.0	0.7	-0.9	1.0	0.8	1.0	-0.7	-0.7	-0.7
Rb content in liver	0.2	0.2	0.6	0.2	-0.4	0.2	-0.3	-0.4	-0.5	0.5	0.8	0.5
Se content in liver	0.2	0.2	0.4	-0.6	0.5	-0.5	0.6	0.4	0.5	-0.7	-0.3	-0.2
Sr content in liver	0.2	0.2	0.3	0.6	-0.3	0.6	-0.5	-0.5	-0.3	0.6	0.3	0.4
Zn content in liver	0.9	0.9	1.8	-1.1	1.0	-1.0	1.0	1.1	0.8	-1.3	-0.7	-0.6
Bone: minimum diameter	8.4	15.6	16.7	-4.0	4.0	-4.1	4.0	4.0	4.0	-3.7	-4.0	-3.7
Time in familiar zone, hab. session 1	0.3	0.3	0.6	-0.6	0.8	-0.6	0.5	0.6	0.5	-0.7	-0.5	-0.2
Time in novel zone, hab. session 1	1.2	1.2	2.1	1.1	-1.4	1.2	-1.1	-1.1	-1.0	1.2	0.9	0.6
Total zone transitions, hab. session 1	0.1	0.2	0.3	-0.5	0.5	-0.5	0.5	0.5	0.5	-0.2	-0.4	-0.4
Total locomotion distance, hab. session 1	2.2	3.1	4.0	-1.8	2.0	-1.8	1.9	1.8	1.8	-1.8	-1.7	-1.2
Locomotion velocity, hab. session 1	2.0	2.8	4.0	-1.7	2.0	-1.7	1.8	1.7	1.7	-1.7	-1.6	-1.0
Time in familiar zone, hab. session 2	0.9	0.9	1.3	1.1	-1.1	1.1	-1.0	-0.9	-1.0	0.9	0.6	0.6
Time in novel zone, hab. session 2	0.5	0.5	0.7	-0.8	0.6	-0.8	0.7	0.7	0.8	-0.5	-0.3	-0.7
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.1	0.0	0.0	-0.1	-0.0	-0.0	0.3	-0.1	-0.1
Total locomotion distance, hab. session 2	0.6	0.8	1.1	-0.8	1.0	-0.9	0.9	0.9	0.9	-0.8	-1.0	-0.7
Locomotion velocity, hab. session 2	0.5	0.7	1.1	-0.8	1.0	-0.9	0.9	0.8	0.8	-0.8	-1.0	-0.6
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.4	0.2	-0.4	0.5	0.3	0.5	-0.1	-0.2	-0.1
Novelty place preference	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.1	-0.0	0.2	0.2	0.1	0.1
Time in novel zone, NPP test	0.1	0.1	0.2	-0.3	-0.0	-0.3	0.4	0.2	0.4	-0.0	-0.1	-0.2
Total zone transitions, NPP test	0.0	0.0	0.0	-0.1	0.1	-0.1	0.1	0.1	0.1	0.1	0.0	0.1
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.4	0.6	-0.4	0.4	0.4	0.3	-0.3	-0.4	-0.1
Locomotion velocity, NPP test	0.0	0.0	0.1	0.0	0.2	-0.0	0.0	0.0	-0.1	0.0	-0.1	0.3
Intraocular pressure	0.7	1.0	1.6	1.1	-1.2	1.1	-1.1	-0.9	-1.1	1.1	0.8	0.5
Delta distance traveled before/after self-admin	0.4	0.4	0.5	-0.6	0.7	-0.6	0.6	0.6	0.7	-0.7	-0.7	-0.6
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.2	0.3	-0.2	0.2	0.2	0.3	-0.3	-0.4	-0.4
Parametrial fat weight	1.1	2.2	3.0	-1.5	1.3	-1.5	1.7	1.5	1.6	-1.4	-1.7	-1.0
Pavlov. Cond. lever latency	1.9	2.5	2.9	1.7	-1.5	1.7	-1.5	-1.5	-1.7	1.5	1.2	1.7
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	0.2	-0.1	0.0	0.1	0.1	-0.1	-0.0	0.1
Pavlov. Cond. change in total contacts	0.4	0.5	0.6	-0.8	0.6	-0.8	0.7	0.7	0.7	-0.7	-0.4	-0.7
Pavlov. Cond. index score	0.6	0.7	1.0	-1.0	0.9	-0.9	0.8	0.8	0.9	-0.8	-0.5	-0.8
Pavlov. Cond. latency score	0.8	1.0	1.3	-1.1	1.0	-1.1	1.0	1.0	1.1	-1.0	-0.7	-1.0
Pavlov. Cond. lever contacts	2.2	2.5	3.0	-1.7	1.5	-1.7	1.6	1.6	1.7	-1.5	-1.3	-1.7
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	-0.1	0.2	-0.1	0.2	0.2	0.2	-0.2	-0.3	-0.2
Pavlov. Cond. intertrial magazine entries	1.7	2.0	3.0	-1.7	1.4	-1.7	1.6	1.4	1.6	-1.2	-1.0	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.8	1.1	-1.0	0.9	-1.0	0.9	0.9	1.0	-0.9	-0.6	-0.7
Pavlov. Cond. response bias	0.6	0.7	0.9	-0.9	0.8	-0.9	0.8	0.8	0.9	-0.8	-0.7	-0.7
Pavlov. Cond. lever latency	0.1	0.2	0.5	-0.4	0.1	-0.4	0.4	0.3	0.5	-0.4	-0.3	-0.7
Pavlov. Cond. magazine entry latency	1.1	1.3	1.7	1.2	-0.9	1.1	-1.1	-1.1	-1.1	1.3	1.0	1.3
Pavlov. Cond. change in total contacts	0.4	0.5	1.1	0.7	-0.4	0.7	-0.7	-0.6	-0.8	0.7	0.7	1.0
Pavlov. Cond. index score	0.7	0.9	1.6	1.0	-0.6	0.9	-1.0	-0.9	-1.0	1.0	0.9	1.3
Pavlov. Cond. latency score	1.0	1.3	1.7	1.2	-0.8	1.1	-1.2	-1.1	-1.2	1.2	1.1	1.3
Pavlov. Cond. lever contacts	0.1	0.1	0.5	0.2	0.1	0.2	-0.2	-0.2	-0.3	0.3	0.2	0.7
Pavlov. Cond. magazine entry number	1.7	2.1	2.8	-1.5	1.2	-1.4	1.5	1.4	1.4	-1.7	-1.3	-1.6
Pavlov. Cond. intertrial magazine entries	2.4	3.2	3.8	-1.9	1.6	-1.9	1.9	1.7	1.9	-1.8	-1.6	-1.6
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.6	0.9	-0.5	0.8	-0.9	-0.8	-0.9	0.9	0.8	1.2
Pavlov. Cond. response bias	0.6	0.9	1.9	0.9	-0.5	0.9	-0.9	-0.8	-1.0	1.0	0.8	1.4
Time in closed arm before self-admin	1.1	1.3	1.8	-1.2	1.3	-1.1	1.3	1.1	1.1	-1.3	-1.0	-0.4
Time in closed arm after self-admin	0.0	0.0	0.1	0.2	-0.1	0.3	-0.3	-0.1	-0.3	-0.1	0.1	0.1
Time in open arm before self-admin	0.2	0.2	0.6	0.6	-0.4	0.4	-0.8	-0.4	-0.5	0.5	0.5	-0.2
Time in open arm after self-admin	0.9	1.0	1.4	-1.1	1.0	-1.1	1.2	1.0	1.2	-0.9	-0.9	-0.8
Bone: periosteal estimation	1.9	3.9	4.4	-2.1	2.1	-2.1	2.1	2.0	1.9	-1.8	-1.9	-1.8
Bone: periosteal perimeter	0.9	1.5	1.8	-1.2	1.3	-1.4	1.3	1.2	1.2	-0.9	-1.1	-1.2
Bone: post-yield work	0.4	0.5	0.7	-0.7	0.6	-0.7	0.7	0.7	0.7	-0.6	-0.8	-0.6
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	0.2	-0.2	0.2	-0.2	-0.2	-0.2	0.2	0.0	0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.1	0.3	-0.3	0.3	-0.4	-0.3	-0.3	0.4	0.2	0.1
Progressive ratio test 1 inactive lever presses	1.7	1.9	2.8	-1.3	1.4	-1.2	1.3	1.4	1.4	-1.7	-1.3	-1.4
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	0.1	-0.0	0.0	0.1	0.0	-0.2	-0.2	-0.2
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	-0.1	0.1	-0.0	0.0	0.1	0.1	-0.2	-0.2	-0.3
Progressive ratio test 2 inactive lever presses	0.4	0.4	0.8	-0.6	0.7	-0.5	0.6	0.6	0.5	-0.9	-0.8	-0.5
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	-0.1	0.2	-0.2	-0.2	-0.2	-0.1	0.1	-0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	-0.0	0.0	0.1	-0.1	-0.0	-0.1	-0.2	-0.0	-0.1
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	-0.2	0.3	-0.1	0.2	0.2	0.1	-0.3	-0.4	-0.2
Progressive ratio	0.4	0.4	0.6	0.6	-0.5	0.6	-0.6	-0.7	-0.6	0.6	0.8	0.7
Food seeking constrained by brief footshock	0.4	0.5	0.7	0.8	-0.8	0.7	-0.7	-0.8	-0.7	0.8	0.6	0.4
Seeking ratio, punishment vs. effort	0.2	0.2	0.4	-0.4	0.2	-0.4	0.4	0.5	0.4	-0.4	-0.6	-0.7
Retroperitoneal fat weight	0.6	2.0	2.8	-1.7	1.2	-1.6	1.6	1.4	1.6	-1.1	-1.1	-1.2
Reaction time number correct	0.1	0.1	0.5	-0.3	0.3	-0.4	0.0	0.2	0.3	0.3	-0.0	-0.7
Reaction time mean minus median	1.0	1.3	1.9	1.2	-1.4	1.2	-1.1	-1.2	-1.1	1.3	0.9	0.9
Reaction time mean minus median AUC	0.7	0.9	1.6	1.0	-1.3	0.9	-0.8	-0.9	-0.8	1.1	0.9	0.6
Reaction time num false alarms	0.2	0.3	1.5	-0.4	0.2	-0.5	0.4	0.4	0.6	-0.4	-0.3	-1.2
Reaction time num false alarms AUC	0.0	0.1	0.4	0.1	-0.4	0.0	-0.1	-0.1	0.1	0.1	0.2	-0.6
Reaction time trials correct on left	0.1	0.1	0.5	-0.3	0.3	-0.4	0.0	0.2	0.3	0.3	-0.0	-0.7
Reaction time trials on left	0.1	0.1	0.5	-0.2	0.2	-0.4	-0.0	0.2	0.3	0.3	0.0	-0.7
Reaction time mean	0.8	1.1	1.4	1.0	-1.2	1.1	-1.0	-1.1	-1.0	0.9	0.9	1.1
Reaction time mean AUC	0.5	0.7	1.0	0.8	-1.0	0.9	-0.7	-0.9	-0.8	0.7	0.7	1.0
Median of all reaction times	0.7	0.9	1.3	0.9	-1.1	1.1	-0.9	-1.0	-1.0	0.8	0.9	1.1
Reaction time omissions	2.0	2.7	3.4	1.8	-1.8	1.7	-1.8	-1.6	-1.6	1.8	1.4	0.7
Reaction time false alarm rate	0.0	0.0	0.1	0.1	-0.4	0.2	0.0	-0.1	0.0	-0.2	0.1	-0.2
Reaction time premature initiation rate	0.1	0.1	0.2	-0.4	0.3	-0.2	0.4	0.3	0.3	-0.5	-0.4	-0.1
Reaction time premature initiations	0.2	0.3	0.4	-0.7	0.5	-0.6	0.5	0.5	0.6	-0.4	-0.5	-0.6
Std. dev. reaction times	0.6	0.8	1.2	0.9	-1.1	0.9	-0.8	-0.9	-0.8	0.9	0.7	0.7
Reaction time trials completed	0.1	0.1	0.5	-0.2	0.2	-0.4	-0.0	0.2	0.3	0.3	0.0	-0.7
Reaction time trials AUC	0.1	0.1	0.6	-0.2	0.2	-0.4	-0.0	0.1	0.3	0.4	0.1	-0.7
Run reversals in cocaine runway, females	7.0	6.8	8.3	-2.6	2.6	-2.7	2.5	2.6	2.6	-2.4	-2.3	-2.9
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.0	0.1	-0.0	-0.1	-0.0	0.0	-0.0	0.3	0.0
Latency to leave start box in cocaine runway	0.7	0.8	1.4	-0.9	0.9	-0.8	1.1	0.9	0.9	-0.6	-1.2	-0.6
Latency to leave start box in cocaine runway, F	2.6	2.8	3.7	-1.7	1.6	-1.7	1.9	1.7	1.7	-1.5	-1.9	-1.2
Latency to leave start box in cocaine runway, M	0.7	0.7	1.1	0.8	-0.7	0.8	-0.8	-0.8	-0.8	1.0	0.7	0.9
Std. dev. time between licks in bursts	0.4	0.5	1.6	0.5	-0.3	0.5	-0.5	-0.6	-0.7	0.4	0.9	1.3
Total sessions with >9 infusions	2.4	2.7	3.2	1.8	-1.6	1.7	-1.8	-1.7	-1.7	1.6	1.5	1.3
Short access day 1 total inactive lever presses	0.7	0.8	1.6	-0.8	1.1	-0.7	0.8	0.8	0.7	-1.3	-0.8	-0.7
Short access day 10 total inactive lever presses	0.5	0.6	1.1	-0.6	0.9	-0.6	0.7	0.8	0.6	-1.0	-0.8	-0.8
Short access day 1 total infusions	0.0	0.0	0.0	0.1	-0.1	0.1	-0.0	-0.0	-0.0	-0.0	-0.0	-0.1
Short access day 10 total infusions	1.0	1.1	1.6	1.2	-1.0	1.2	-1.1	-1.1	-1.1	0.9	0.7	0.9
Short access total infusions	1.2	1.4	1.9	1.4	-1.2	1.3	-1.2	-1.2	-1.2	1.1	1.0	0.8
Short access day 1 locomotion	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.1	-0.1	-0.0	0.2	-0.0	-0.0
Short access day 10 total locomotion	0.3	0.4	0.7	0.7	-0.8	0.7	-0.6	-0.6	-0.6	0.4	0.4	0.3
Short access total locomotion	0.7	0.7	0.9	1.0	-1.0	0.9	-1.0	-0.9	-0.8	0.9	0.7	0.5
One hour access (0.3 mA shock)	0.0	0.0	0.1	0.3	-0.1	0.3	-0.2	-0.2	-0.2	0.1	-0.3	0.1
Compulsive drug intake	0.6	0.6	1.0	0.9	-1.0	0.8	-0.5	-0.8	-0.7	0.6	0.5	0.8
One hour access (shock baseline)	0.1	0.1	0.2	-0.2	0.3	-0.2	0.1	0.2	0.2	-0.2	-0.3	-0.4
Social response proportion	0.4	0.4	0.9	-0.6	0.4	-0.5	0.7	0.5	0.7	-0.7	-0.9	-0.7
Social responses	0.7	0.9	1.9	-0.9	0.8	-0.9	0.9	0.9	1.0	-1.0	-0.9	-1.4
Social time	0.6	0.8	1.2	-1.0	0.9	-0.9	1.1	0.9	0.9	-0.9	-0.8	-0.4
Soleus weight	0.3	0.8	1.1	0.9	-0.6	0.9	-1.0	-0.9	-1.0	0.7	1.0	1.0
Bone: stiffness	2.4	3.7	4.5	-2.1	1.8	-2.1	2.0	2.0	2.0	-1.6	-1.8	-1.9
Tibialis anterior weight	4.5	15.5	17.3	4.0	-4.2	3.9	-4.1	-4.0	-3.9	4.1	3.9	3.3
Time to tail flick, vehicle, before self-admin	0.8	0.8	0.9	-0.9	0.9	-0.9	0.9	0.9	0.9	-0.7	-0.9	-0.7
Time to tail flick, vehicle, after self-admin	1.9	2.0	2.9	-1.5	1.7	-1.5	1.2	1.5	1.3	-1.5	-1.3	-1.3
Time to tail flick, test, before self-admin	0.4	0.3	0.5	-0.7	0.7	-0.7	0.6	0.6	0.6	-0.7	-0.3	-0.3
Time to tail flick, test, after self-admin	5.0	5.2	5.6	-2.4	2.3	-2.3	2.3	2.3	2.4	-2.3	-2.1	-2.3
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.2	-1.0	1.0	-1.0	0.7	1.0	0.9	-1.0	-0.7	-1.1
Delta time to tail flick, test, before/after SA	1.4	1.2	1.7	-1.0	0.9	-1.0	1.1	1.1	1.1	-1.1	-1.2	-1.3
Tibia length	0.4	1.0	1.1	-1.1	0.9	-1.1	1.0	1.0	1.1	-0.8	-1.0	-1.0
Ambulatory time before self-admin	1.1	1.1	1.4	-1.1	1.1	-1.1	1.1	1.1	1.0	-1.2	-1.0	-0.8
Ambulatory time after self-admin	2.5	2.7	3.3	-1.6	1.8	-1.7	1.7	1.7	1.6	-1.7	-1.8	-1.2
Bone: tissue strength	1.3	1.3	1.7	-1.1	1.1	-1.2	1.1	1.2	1.1	-1.0	-1.1	-1.3
Total heroin consumption	2.3	2.7	2.9	-1.6	1.7	-1.7	1.6	1.6	1.7	-1.6	-1.7	-1.7
Bone: trabecular number	0.1	0.2	0.5	0.3	-0.5	0.3	-0.3	-0.4	-0.3	0.6	0.5	0.7
Bone: trabecular spacing	0.0	0.0	0.1	0.1	-0.3	0.1	-0.2	-0.2	-0.0	0.1	0.2	-0.3
Bone: trabecular thickness	0.1	0.1	0.2	-0.4	0.5	-0.3	0.4	0.4	0.3	-0.3	-0.3	-0.1
Bone: trabecular tissue density	0.2	0.2	0.3	0.3	-0.5	0.4	-0.3	-0.5	-0.4	0.6	0.6	0.6
Water consumed over 24 hours	1.6	1.9	2.7	-1.3	1.3	-1.3	1.3	1.5	1.4	-1.2	-1.5	-1.6
Number of responses in last shaping day	1.2	1.2	1.4	1.2	-1.2	1.2	-1.1	-1.2	-1.0	1.1	1.1	1.0