LOC120095873

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC120095873	0.04	0.03	1.1e-03	0.01	0.02	0.03	0.01	2.7e-02	3.6e-03	8.8e-04	2.3e-02
2	NAcc	gene expression	LOC120095873	0.04	0.03	8.1e-04	0.02	0.02	0.02	0.02	6.9e-04	3.9e-03	3.4e-03	3.9e-03
3	BLA	gene expression	LOC120095873	0.17	0.11	3.4e-04	0.05	0.06	0.08	0.05	9.7e-04	3.0e-04	5.7e-05	1.0e-03
4	Brain	gene expression	LOC120095873	0.58	0.05	0.0e+00	0.46	0.47	0.48	0.48	5.8e-47	8.2e-49	5.9e-50	5.8e-50
5	Adipose	gene expression	LOC120095873	0.2	0.13	3.8e-07	0.05	0.04	0.05	0.05	7.0e-06	1.7e-05	1.6e-06	6.0e-06
6	pVTA	gene expression	LOC120095873	0.48	0.15	3.0e-08	0.16	0.18	0.2	0.19	2.6e-07	2.2e-08	7.1e-09	9.5e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	9.4	15.8	21.5	4.3	2.8	4.6	-4.3	-3.9	3.7
Area under the delay curve	1.0	1.1	2.4	-1.6	-1.1	-1.2	0.9	0.6	-0.5
BMI with tail	1.6	5.1	6.8	2.0	1.4	2.4	-2.5	-2.6	2.4
BMI without tail	1.4	2.9	5.9	2.4	2.4	1.9	-1.1	-1.0	0.6
Body weight	9.3	38.8	58.1	7.6	7.2	6.8	-5.8	-5.1	4.2
Weight adjusted by age	0.7	0.8	1.4	1.2	1.1	0.8	-0.7	-0.7	0.5
Bone surface	9.0	15.9	21.4	4.3	3.0	4.6	-4.3	-3.9	3.6
Bone volume	9.1	15.5	20.4	3.8	2.0	4.5	-4.4	-4.2	4.1
Breakpoint value in progressive ratio session	0.2	0.2	0.5	0.3	0.1	0.4	-0.6	-0.7	0.4
Number of licking bursts	2.9	3.4	5.6	-0.3	1.3	-1.7	2.2	2.2	-2.4
Context. condit. distance diff. score	5.2	6.3	8.5	2.8	2.2	2.9	-2.5	-2.4	2.2
Locomotion velocity, session 1	0.5	0.5	0.7	-0.8	-0.8	-0.7	0.7	0.7	-0.6
Locomotion distance, session 1	1.1	1.4	2.2	-1.5	-1.4	-1.4	1.1	0.9	-0.7
Locomotion velocity, session 2	1.6	1.9	2.7	-1.1	-0.5	-1.5	1.5	1.7	-1.6
Locomotion distance, session 2	1.8	2.5	3.7	-1.6	-1.0	-1.9	1.7	1.7	-1.5
Locomotion velocity, session 3	1.0	1.1	1.7	0.9	0.4	1.1	-1.1	-1.3	1.3
Locomotion distance, session 3	0.4	0.4	0.7	0.5	0.2	0.6	-0.7	-0.7	0.8
Stereotopy head waving bouts, day 3	2.1	2.5	3.7	1.9	1.9	1.6	-1.3	-1.4	1.0
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.1	0.1	0.3	-0.4	-0.5	0.4
Locomotion velocity, session 7	1.9	2.1	3.0	-1.5	-0.8	-1.7	1.6	1.4	-1.4
Locomotion distance, session 7	0.4	0.5	1.0	-0.7	-0.2	-1.0	0.7	0.6	-0.6
Stereotopy head waving bouts, day 7	0.1	0.2	0.5	-0.6	-0.7	-0.3	0.2	0.0	-0.0
Stereotopy head waving duration, day 7	0.5	0.6	0.9	-0.9	-0.9	-0.8	0.7	0.7	-0.7
Locomotion velocity, session 8	0.1	0.1	0.1	-0.1	0.3	-0.3	0.2	0.4	-0.4
Locomotion distance, session 8	0.9	1.3	1.7	1.3	1.2	1.2	-1.0	-1.0	0.9
Degree of sensitization distance	2.8	2.8	4.0	-1.7	-1.0	-2.0	1.8	1.7	-1.6
Degree of sensitization stereotypy	0.2	0.2	0.6	-0.6	-0.8	-0.2	0.2	0.2	-0.1
Conditioned locomotion	2.0	2.3	3.8	0.9	-0.1	1.6	-1.9	-1.8	2.0
Cocaine response after cond. corrected	0.4	0.4	0.7	0.1	-0.6	0.6	-0.8	-0.7	0.8
Cocaine response after cond. not corrected	1.2	1.3	2.1	0.4	-0.6	1.2	-1.5	-1.4	1.5
Cocaine response before conditioning	1.0	1.2	1.9	0.7	0.2	1.2	-1.2	-1.4	1.3
Saline control response	1.4	1.9	6.8	1.5	2.6	0.2	0.5	0.9	-1.2
Bone: connectivity density	9.4	14.9	20.5	4.5	3.7	4.4	-3.9	-3.4	3.0
Bone: cortical apparent density	0.3	0.5	0.8	-0.9	-0.8	-0.8	0.6	0.4	-0.3
Bone: cortical area	1.4	2.1	2.8	1.6	1.5	1.7	-1.4	-1.3	1.1
Bone: cortical porosity	0.2	0.2	0.3	-0.3	-0.0	-0.5	0.5	0.6	-0.5
Bone: cortical porosity	0.6	0.7	0.9	-0.8	-0.5	-1.0	1.0	0.9	-0.8
Bone: cortical thickness	1.3	2.1	2.8	1.7	1.5	1.7	-1.4	-1.3	1.1
Bone: cortical thickness	0.4	0.5	1.7	0.9	1.3	0.3	-0.1	0.0	-0.3
Bone: cortical tissue density	0.4	0.5	0.9	-0.9	-0.8	-0.8	0.6	0.4	-0.3
Condit. Reinf. active minus inactive responses	0.4	0.5	1.4	-1.0	-1.2	-0.6	0.4	0.1	-0.0
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.7	-0.6	-0.9	-0.2	0.0	-0.1	0.1
Condit. Reinf. active responses	0.3	0.4	0.7	-0.8	-0.8	-0.7	0.6	0.2	-0.2
Condit. Reinf. inactive responses	0.7	0.8	1.3	-0.9	-0.6	-1.0	1.1	0.9	-0.7
Incentive salience index mean	0.2	0.3	1.0	-0.6	-1.0	-0.2	-0.0	-0.3	0.3
Condit. Reinf. lever presses	0.2	0.3	0.5	-0.1	-0.7	0.4	-0.5	-0.7	0.7
Condit. Reinf. active minus inactive responses	0.8	1.1	2.0	0.2	1.3	-0.5	1.0	1.2	-1.4
Condit. Reinf. active-inactive response ratio	2.1	2.2	3.9	-0.7	0.5	-1.4	1.7	1.9	-2.0
Condit. Reinf. active responses	0.4	0.5	2.1	0.9	1.5	0.4	-0.1	0.1	-0.4
Condit. Reinf. inactive responses	1.2	1.4	1.9	1.2	1.0	1.4	-1.3	-1.2	1.0
Condit. Reinf. lever presses	0.8	1.1	1.4	0.9	0.6	1.1	-1.1	-1.2	1.1
Condit. Reinf. lever reinforcers received	0.3	0.4	1.3	0.4	1.1	-0.0	0.3	0.6	-0.8
Conditioned reinforcement - actives	2.2	2.2	6.7	2.1	2.6	1.3	-0.5	0.2	-0.5
Conditioned reinforcement - inactives	0.2	0.2	0.9	0.5	0.9	0.1	0.0	0.3	-0.3
Conditioned locomotion	2.1	2.5	5.4	2.3	2.2	1.9	-1.0	-0.6	0.4
Patch foraging indifference point 0 sec	1.3	2.1	3.9	1.1	0.3	1.5	-1.5	-2.0	1.7
Patch foraging indifference point AUC	0.7	0.7	1.4	1.2	1.2	1.0	-0.7	-0.4	0.4
Delay disc. indifference point, 0s delay	0.4	0.5	0.9	-1.0	-0.6	-0.7	0.7	0.5	-0.6
Delay disc. indifference point, 16s delay	0.2	0.2	0.4	-0.6	-0.6	-0.4	0.3	0.3	-0.3
Delay disc. indifference point, 2s delay	1.7	1.9	5.0	-2.2	-1.9	-1.4	0.7	0.1	0.2
Delay disc. indifference point, 24s delay	0.7	0.7	0.8	-0.9	-0.7	-0.9	0.8	0.8	-0.7
Delay disc. indifference point, 4s delay	0.7	0.7	1.9	-1.4	-1.3	-0.6	0.2	-0.3	0.5
Delay disc. indifference point, 8s delay	0.5	0.5	1.1	-1.0	-0.7	-0.8	0.6	0.6	-0.4
Indifference point function ln k	0.5	0.7	1.2	-0.3	0.4	-0.9	1.0	0.9	-1.1
Indifference point function log k	0.5	0.7	1.2	-0.3	0.4	-0.9	1.0	0.9	-1.1
Patch foraging total patch changes 0 sec	1.5	2.4	4.3	1.2	0.3	1.5	-1.6	-2.1	1.8
Patch foraging total patch changes 12 sec	1.8	2.3	3.5	1.2	0.5	1.6	-1.7	-1.9	1.8
Patch foraging total patch changes 18 sec	1.1	1.4	2.2	1.0	0.3	1.3	-1.3	-1.5	1.5
Patch foraging total patch changes 24 sec	1.3	1.6	2.3	1.0	0.3	1.4	-1.3	-1.5	1.5
Patch foraging total patch changes 6 sec	1.6	2.3	3.3	1.4	0.8	1.6	-1.7	-1.8	1.6
Patch foraging time to switch 0 sec	1.2	1.9	5.8	-2.0	-2.4	-1.2	0.5	0.1	0.3
Patch foraging water rate 0 sec	2.4	3.9	8.9	2.7	3.0	1.9	-1.3	-1.1	0.6
Patch foraging water rate 12 sec	0.2	0.3	1.1	0.6	1.0	0.1	0.1	0.2	-0.6
Patch foraging water rate 18 sec	1.0	1.3	2.4	-0.7	0.0	-1.1	1.4	1.4	-1.6
Patch foraging water rate 24 sec	0.9	1.2	4.4	1.5	2.1	0.6	-0.1	-0.1	-0.4
Patch foraging water rate 6 sec	1.0	1.4	2.1	1.3	0.9	1.4	-1.3	-1.1	1.0
Seeking ratio, delayed vs. immediate footshock	1.3	1.5	2.4	-1.5	-1.3	-1.4	1.1	0.9	-0.8
Distance traveled before self-admin	0.7	0.8	1.0	-1.0	-1.0	-1.0	0.8	0.8	-0.6
Distance traveled after self-admin	0.1	0.1	0.2	0.5	0.3	0.4	-0.3	0.1	0.1
Extensor digitorum longus weight	3.7	14.6	22.9	4.8	4.3	4.3	-3.5	-3.0	2.5
Bone: elastic displacement	0.3	0.3	0.8	0.8	0.9	0.5	-0.1	0.1	-0.3
Bone: elastic work	2.9	3.8	7.0	2.7	2.6	2.2	-1.6	-1.1	0.7
Bone: endosteal estimation	0.7	1.6	3.2	1.7	1.8	1.3	-1.0	-0.8	0.6
Bone: endosteal perimeter	0.9	1.9	2.8	1.7	1.6	1.5	-1.2	-1.2	1.0
Epididymis fat weight	1.3	3.1	4.7	1.3	0.1	2.0	-2.2	-2.1	2.0
Delta time in closed arm before/after self-admin	0.7	0.7	2.0	0.1	0.3	-0.4	0.9	1.4	-1.1
Delta time in open arm before/after self-admin	1.5	1.5	3.6	-1.7	-1.9	-0.8	0.2	-1.1	0.7
Diff in mean of infusions in LGA sessions	0.4	0.4	0.7	0.7	0.3	0.8	-0.8	-0.6	0.4
Delay discount exponential model param	1.0	1.1	2.4	1.6	1.1	1.2	-0.9	-0.6	0.4
Extinction: sum of active levers before priming	0.5	0.5	1.5	-0.9	-1.2	-0.1	-0.4	-0.4	0.6
Active lever presses in extinction session 6	1.0	1.0	1.6	0.8	0.4	1.0	-1.3	-1.0	1.3
Bone: final force	0.9	1.5	4.3	1.7	2.1	1.2	-0.5	-0.2	-0.1
Bone: final moment	0.7	1.1	3.6	1.5	1.9	0.9	-0.3	0.0	-0.3
Food consumed during 24 hour testing period	0.2	0.3	0.6	0.1	0.8	-0.5	0.7	0.4	-0.5
Glucose	0.9	1.3	2.4	-1.6	-1.0	-1.4	1.1	0.8	-0.7
Heart weight	1.3	1.9	3.3	0.2	1.1	-0.9	1.6	1.8	-1.8
Delay discount hyperbolic model param	1.1	1.2	2.8	1.7	1.2	1.3	-0.9	-0.6	0.3
Intermittent access intake day 1-15 change	1.3	1.3	2.9	1.7	1.6	1.1	-0.8	-0.4	0.4
Intermittent access intake escalation	1.3	1.3	2.9	1.7	1.6	1.2	-0.8	-0.4	0.4
Intermittent access intake escalation 2	0.3	0.3	0.6	0.8	0.6	0.6	-0.5	-0.4	0.3
Intermitt. access day 1 inactive lever presses	0.3	0.3	0.9	0.6	1.0	0.3	0.0	0.3	-0.5
Intermitt. access day 15 inactive lever presses	0.1	0.1	0.4	-0.3	-0.7	0.1	-0.4	-0.2	0.3
Intermitt. access escalation Index	0.1	0.1	0.3	-0.2	0.0	-0.1	0.1	0.6	-0.4
Intermittent access day 1 total infusions	0.5	0.6	1.1	-1.1	-0.9	-0.8	0.7	0.4	-0.3
Intermittent access day 15 total infusions	0.2	0.2	0.3	0.6	0.5	0.6	-0.4	-0.4	0.4
Intermittent access terminal intake (last 3 days)	0.0	0.0	0.1	-0.1	-0.2	0.2	-0.2	-0.3	0.3
Intermittent access total infusions	0.2	0.2	0.5	-0.7	-0.7	-0.3	0.2	-0.1	0.1
Intermittent access day 1 locomotion	0.8	0.8	2.3	-1.4	-1.5	-0.7	0.3	0.1	-0.1
Intermittent access day 15 total locomotion	0.1	0.1	0.1	0.3	0.4	0.3	-0.1	0.2	-0.1
Intermittent access total locomotion	0.5	0.5	1.2	-1.1	-0.9	-0.7	0.6	0.4	-0.4
Intermittent access standard deviation	1.2	1.3	1.6	1.3	0.5	1.2	-1.1	-1.3	1.2
Left kidney weight	5.7	16.0	36.3	5.5	6.0	3.9	-2.7	-2.2	1.6
Right kidney weight	4.4	12.2	26.0	4.6	5.1	3.4	-2.6	-2.3	1.6
Cocaine induced anxiety	0.6	0.7	1.2	0.1	-0.7	0.7	-1.0	-1.0	1.1
Post-drug Anxiety	2.8	3.1	7.6	-2.7	-2.3	-1.9	1.0	0.8	-0.6
Baseline Anxiety	4.8	5.1	10.9	-3.3	-2.3	-2.7	1.9	1.4	-1.3
Tail length	3.8	11.6	26.0	5.0	5.1	3.6	-2.1	-1.2	0.5
Length with tail	9.3	34.1	64.3	7.8	8.0	6.2	-4.7	-3.5	2.6
Length without tail	8.6	18.8	24.4	4.9	4.5	4.8	-4.4	-3.8	3.4
Times rat made contact with spout	1.5	1.8	3.0	0.2	1.3	-1.0	1.6	1.5	-1.7
Lifetime Intake	0.3	0.3	0.9	-0.8	-0.9	-0.3	0.1	-0.3	0.2
Liver weight, left	1.5	2.4	2.8	1.5	1.5	1.5	-1.7	-1.6	1.6
Liver weight, right	3.7	6.2	8.5	2.8	2.9	2.5	-2.5	-2.1	1.9
Locomotor activity	0.7	1.1	4.6	1.2	2.1	0.1	0.3	0.5	-0.7
Locomotor testing distance	0.4	0.7	2.3	1.1	1.5	0.5	-0.3	-0.1	-0.0
Locomotor testing rearing	0.1	0.1	0.2	0.1	0.1	0.2	-0.2	-0.5	0.3
Locomotion in novel chamber	0.5	0.6	1.2	0.4	1.0	-0.3	0.7	0.9	-1.1
Locomotion in novel chamber post-restriction	1.0	1.2	4.7	1.3	2.2	0.4	0.1	0.3	-0.7
Fecal boli incidents, locomotor time 1	0.8	0.8	2.6	1.2	1.6	0.8	-0.4	0.1	-0.2
Change in fecal boli incidents, locomotor task	0.4	0.4	0.9	-0.8	-0.9	-0.7	0.4	0.1	-0.4
Time >=10cm from walls, locomotor time 1	0.5	0.5	1.8	-0.9	-1.3	-0.4	0.1	-0.3	0.5
Bouts of movement, locomotor time 1	0.7	0.7	2.4	1.1	1.5	0.7	-0.4	0.3	-0.2
Total resting periods, locomotor time 1	0.6	0.7	2.2	1.1	1.5	0.7	-0.3	0.4	-0.3
Rest time, locomotor task time 1	0.5	0.6	1.2	1.1	0.9	0.9	-0.8	0.1	0.2
Distance moved, locomotor task time 1	0.5	0.6	1.1	-0.9	-0.6	-1.0	1.0	0.4	-0.5
Vertical activity count, locomotor time 1	0.1	0.1	0.3	0.5	0.5	0.3	0.2	0.1	-0.2
Time >=10cm from walls, locomotor time 2	1.1	1.1	2.0	0.7	0.1	1.1	-1.1	-1.3	1.4
Bouts of movement, locomotor time 2	2.7	2.9	4.3	2.1	1.4	2.1	-1.6	-1.5	1.4
Total resting periods, locomotor time 2	2.8	3.0	4.4	2.1	1.4	2.1	-1.6	-1.5	1.5
Rest time, locomotor task time 2	0.1	0.1	0.2	-0.4	-0.4	-0.1	-0.2	0.1	-0.1
Distance moved, locomotor task time 2	0.4	0.5	0.8	0.1	0.5	-0.6	0.9	0.9	-0.9
Vertical activity count, locomotor time 2	1.6	1.7	4.3	2.1	2.0	1.2	-0.4	-0.2	0.0
Light reinforcement 1	0.8	1.4	2.4	-1.6	-1.4	-1.3	1.1	0.6	-0.7
Light reinforcement 2	0.6	0.8	1.4	-1.0	-0.5	-1.2	1.0	0.7	-0.9
Bone: marrow area	0.7	1.6	3.3	1.7	1.8	1.3	-0.9	-0.8	0.6
Bone: maximum diameter	1.3	2.4	3.2	1.8	1.7	1.7	-1.5	-1.4	1.2
Bone: maximum force	1.5	2.5	4.7	2.2	2.1	1.8	-1.2	-0.9	0.7
Bone: maximum moment	1.1	1.9	3.7	1.9	1.9	1.5	-1.0	-0.7	0.5
Mean time between licks in bursts	0.7	1.0	2.1	-1.4	-1.4	-1.1	0.6	0.5	-0.3
Mean num. licks in bursts	0.6	0.8	1.1	0.5	-0.2	1.0	-1.1	-1.0	1.0
Cd content in liver	1.6	1.8	2.8	-1.3	-0.6	-1.7	1.4	1.4	-1.4
Co content in liver	0.3	0.3	0.6	0.2	0.7	-0.4	0.4	0.7	-0.8
Cu content in liver	0.4	0.5	0.9	0.7	0.2	0.9	-1.0	-0.4	0.6
Fe content in liver	5.0	6.0	8.3	2.6	1.8	2.9	-2.6	-2.4	2.3
K content in liver	0.4	0.4	0.7	0.3	-0.2	0.6	-0.9	-0.6	0.8
Mg content in liver	0.1	0.1	0.3	0.5	0.5	0.3	-0.3	-0.0	0.1
Mn content in liver	0.4	0.5	0.8	-0.7	-0.6	-0.9	0.6	0.7	-0.5
Na content in liver	0.0	0.0	0.1	0.2	0.3	0.2	-0.3	0.1	0.1
Rb content in liver	0.9	1.2	3.7	-1.2	-1.9	-0.3	-0.5	-0.7	1.0
Se content in liver	3.2	3.9	5.9	1.3	0.2	2.3	-2.4	-2.3	2.3
Sr content in liver	0.1	0.1	0.2	0.3	0.4	0.0	0.1	0.1	-0.1
Zn content in liver	2.7	3.0	4.8	2.2	1.9	2.1	-1.6	-1.3	1.1
Bone: minimum diameter	0.1	0.2	0.4	-0.5	-0.0	-0.6	0.6	0.4	-0.5
Time in familiar zone, hab. session 1	0.1	0.1	0.4	-0.4	-0.6	-0.2	-0.0	-0.2	0.1
Time in novel zone, hab. session 1	0.1	0.1	0.4	0.5	0.6	0.3	-0.1	-0.0	0.1
Total zone transitions, hab. session 1	0.8	1.1	2.1	-1.4	-1.2	-1.2	0.8	0.7	-0.5
Total locomotion distance, hab. session 1	0.5	0.7	1.7	-0.6	-1.3	0.2	-0.6	-0.8	1.0
Locomotion velocity, hab. session 1	0.6	0.9	3.3	-1.2	-1.8	-0.4	-0.1	-0.3	0.6
Time in familiar zone, hab. session 2	0.3	0.3	0.6	0.0	-0.4	0.4	-0.6	-0.7	0.7
Time in novel zone, hab. session 2	0.5	0.5	0.7	-0.6	-0.2	-0.8	0.9	0.8	-0.7
Total zone transitions, hab. session 2	0.8	1.1	1.8	-0.4	0.4	-1.1	1.2	1.3	-1.3
Total locomotion distance, hab. session 2	0.3	0.4	0.6	-0.7	-0.5	-0.8	0.7	0.4	-0.4
Locomotion velocity, hab. session 2	0.3	0.4	0.7	-0.7	-0.5	-0.9	0.8	0.5	-0.5
Novel to familiar place preference ratio	2.1	2.2	3.6	-0.9	-0.3	-1.5	1.8	1.9	-1.8
Novelty place preference	2.6	2.6	4.1	-1.2	-0.6	-1.7	1.9	2.0	-1.9
Time in novel zone, NPP test	2.0	2.1	3.5	-1.0	-0.4	-1.4	1.7	1.9	-1.7
Total zone transitions, NPP test	0.2	0.3	0.8	-0.1	0.2	-0.4	0.4	0.9	-0.7
Total locomotion distance, NPP test	0.1	0.1	0.2	-0.0	-0.4	0.4	-0.4	-0.3	0.5
Locomotion velocity, NPP test	0.0	0.0	0.1	0.1	-0.1	0.2	-0.2	-0.1	0.2
Intraocular pressure	2.1	2.9	3.6	1.9	1.7	1.8	-1.9	-1.5	1.4
Delta distance traveled before/after self-admin	0.5	0.6	1.2	1.1	1.0	0.9	-0.5	-0.2	0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	0.5	0.4	0.5	-0.3	-0.3	0.3
Parametrial fat weight	0.0	0.0	0.0	0.1	0.2	-0.0	-0.1	-0.1	0.0
Pavlov. Cond. lever latency	1.2	1.5	3.7	1.8	1.9	1.2	-0.8	-0.5	0.2
Pavlov. Cond. magazine entry latency	0.2	0.2	0.4	0.1	0.5	-0.3	0.6	0.3	-0.5
Pavlov. Cond. change in total contacts	0.4	0.5	1.1	-1.0	-1.1	-0.6	0.5	0.2	-0.2
Pavlov. Cond. index score	0.1	0.1	0.2	-0.4	-0.4	-0.2	0.2	-0.1	0.1
Pavlov. Cond. latency score	0.2	0.2	0.4	-0.7	-0.7	-0.5	0.4	0.0	0.0
Pavlov. Cond. lever contacts	0.8	0.9	2.6	-1.4	-1.6	-0.9	0.5	0.2	-0.1
Pavlov. Cond. magazine entry number	0.1	0.1	0.6	-0.5	-0.8	-0.2	-0.1	0.1	0.2
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.2	-1.1	-0.8	-1.1	0.9	1.1	-0.9
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.3	-0.4	-0.0	0.0	-0.2	0.2
Pavlov. Cond. response bias	0.0	0.0	0.0	0.1	0.1	0.2	-0.1	-0.2	0.1
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	0.2	0.3	-0.3	-0.2	0.2
Pavlov. Cond. magazine entry latency	1.3	1.4	3.2	-1.6	-1.8	-1.1	0.9	0.7	-0.5
Pavlov. Cond. change in total contacts	0.1	0.2	0.3	-0.4	-0.0	-0.4	0.6	0.6	-0.6
Pavlov. Cond. index score	0.4	0.5	1.0	-1.0	-0.9	-0.7	0.7	0.5	-0.4
Pavlov. Cond. latency score	0.4	0.5	1.1	-1.0	-1.0	-0.7	0.6	0.4	-0.2
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.3	-0.4	0.2	-0.3	-0.4	0.5
Pavlov. Cond. magazine entry number	1.4	1.7	2.9	1.7	1.6	1.4	-1.2	-1.0	0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	2.0	0.9	1.4	0.2	0.2	0.3	-0.5
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.3	-1.1	-0.9	-0.9	0.9	0.8	-0.6
Pavlov. Cond. response bias	0.2	0.2	0.9	-0.7	-0.9	-0.1	0.0	-0.1	0.2
Time in closed arm before self-admin	0.9	1.1	2.3	1.5	1.5	1.0	-0.7	-0.5	0.2
Time in closed arm after self-admin	1.0	1.1	2.5	1.3	1.6	0.4	0.3	1.0	-1.0
Time in open arm before self-admin	0.4	0.4	1.5	0.1	0.2	-0.5	0.5	1.2	-0.8
Time in open arm after self-admin	0.3	0.3	0.6	-0.4	-0.8	-0.1	-0.2	-0.7	0.6
Bone: periosteal estimation	1.3	2.7	4.6	2.1	2.1	1.8	-1.4	-1.2	0.9
Bone: periosteal perimeter	0.8	1.3	1.7	1.3	1.2	1.3	-1.1	-1.1	0.9
Bone: post-yield work	1.9	2.6	3.6	1.3	0.4	1.8	-1.8	-1.9	1.9
Progressive ratio test 1 active lever presses	0.1	0.1	0.4	0.4	0.7	0.1	0.0	-0.2	-0.1
Progressive ratio test 1 breakpoint	0.1	0.1	0.4	0.3	0.6	0.1	0.1	-0.1	-0.2
Progressive ratio test 1 inactive lever presses	0.5	0.5	1.8	0.6	1.3	-0.0	0.3	0.5	-0.6
Progressive ratio test 2 active lever presses	0.5	0.5	2.0	0.8	1.4	0.4	-0.0	0.2	-0.2
Progressive ratio test 2 breakpoint	0.4	0.4	1.2	0.3	1.1	-0.2	0.5	0.7	-0.7
Progressive ratio test 2 inactive lever presses	1.8	2.1	6.1	2.1	2.5	1.3	-0.7	0.0	-0.2
Incentive Sensitization - Responses	0.1	0.1	0.2	-0.2	0.1	-0.3	0.3	0.4	-0.2
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.1	0.2	-0.2	0.2	0.4	-0.2
Sum of active levers in priming session hrs 5-6	2.1	2.0	4.1	-0.2	-1.3	0.9	-1.5	-2.0	1.8
Progressive ratio	0.5	0.6	0.7	-0.8	-0.9	-0.8	0.8	0.8	-0.7
Food seeking constrained by brief footshock	0.6	0.7	1.6	-0.0	-0.7	0.4	-0.8	-1.2	1.2
Seeking ratio, punishment vs. effort	1.3	1.6	2.0	1.2	0.9	1.3	-1.4	-1.4	1.3
Retroperitoneal fat weight	0.8	2.6	6.2	-1.4	-2.5	0.2	-1.2	-1.7	1.9
Reaction time number correct	0.5	0.8	1.7	1.2	1.3	0.9	-0.6	-0.4	0.3
Reaction time mean minus median	0.1	0.1	0.2	-0.2	0.1	-0.3	0.3	0.2	-0.4
Reaction time mean minus median AUC	0.3	0.3	0.5	-0.6	-0.2	-0.7	0.7	0.4	-0.7
Reaction time num false alarms	1.0	1.4	2.1	-1.1	-0.3	-1.4	1.2	1.4	-1.2
Reaction time num false alarms AUC	0.2	0.2	0.5	-0.6	-0.1	-0.7	0.4	0.6	-0.4
Reaction time trials correct on left	0.5	0.8	1.7	1.2	1.3	0.9	-0.6	-0.4	0.3
Reaction time trials on left	0.5	0.7	1.6	1.2	1.3	0.8	-0.5	-0.4	0.2
Reaction time mean	3.1	4.3	7.1	-2.7	-2.1	-2.3	1.9	1.7	-1.6
Reaction time mean AUC	2.8	3.7	6.3	-2.5	-2.1	-2.1	1.7	1.5	-1.4
Median of all reaction times	4.4	6.1	10.4	-3.2	-2.7	-2.7	2.2	1.9	-1.6
Reaction time omissions	1.2	1.6	2.2	-1.5	-1.2	-1.4	1.2	1.3	-1.0
Reaction time false alarm rate	0.4	0.5	0.9	-0.9	-0.6	-0.9	0.6	0.7	-0.5
Reaction time premature initiation rate	0.1	0.1	0.4	-0.2	-0.1	-0.2	0.5	0.1	-0.6
Reaction time premature initiations	0.1	0.1	0.2	0.4	0.4	0.2	0.2	-0.1	-0.4
Std. dev. reaction times	0.6	0.8	1.4	-1.2	-0.7	-1.1	0.8	0.8	-0.9
Reaction time trials completed	0.5	0.7	1.6	1.2	1.3	0.8	-0.5	-0.4	0.2
Reaction time trials AUC	0.4	0.6	1.2	1.1	1.1	0.8	-0.6	-0.5	0.4
Run reversals in cocaine runway, females	0.2	0.2	0.3	-0.1	-0.6	0.3	-0.5	-0.3	0.4
Run reversals in cocaine runway, males	0.5	0.5	0.8	-0.1	0.4	-0.7	0.9	0.8	-0.8
Latency to leave start box in cocaine runway	1.2	1.2	2.2	-0.8	-0.5	-1.0	1.1	1.5	-1.5
Latency to leave start box in cocaine runway, F	0.2	0.2	0.6	0.1	0.1	-0.2	0.4	0.8	-0.6
Latency to leave start box in cocaine runway, M	0.8	0.8	1.3	-0.9	-0.5	-0.8	0.9	1.0	-1.1
Std. dev. time between licks in bursts	0.1	0.1	0.5	0.4	0.7	0.0	-0.1	0.0	-0.1
Total sessions with >9 infusions	0.0	0.0	0.1	0.1	-0.0	0.2	-0.1	-0.3	0.2
Short access day 1 total inactive lever presses	0.2	0.2	0.4	-0.1	0.4	-0.5	0.6	0.5	-0.6
Short access day 10 total inactive lever presses	1.8	2.0	4.2	2.0	1.7	1.6	-1.2	-0.7	0.8
Short access day 1 total infusions	0.8	0.9	2.4	-1.0	-1.6	-0.3	-0.4	-0.9	0.9
Short access day 10 total infusions	0.5	0.6	1.6	-0.8	-1.3	-0.0	-0.3	-0.8	0.8
Short access total infusions	0.5	0.6	1.9	-1.0	-1.4	-0.4	0.0	-0.5	0.4
Short access day 1 locomotion	1.7	1.8	2.9	-1.7	-1.1	-1.6	1.4	1.1	-1.0
Short access day 10 total locomotion	0.3	0.4	0.9	-0.9	-0.9	-0.6	0.2	-0.2	0.1
Short access total locomotion	1.0	1.1	2.6	-1.6	-1.6	-1.0	0.6	0.2	-0.1
One hour access (0.3 mA shock)	0.5	0.6	1.2	0.3	1.0	-0.4	0.8	0.9	-1.1
Compulsive drug intake	2.1	2.1	3.9	-2.0	-1.6	-1.7	1.4	0.9	-0.9
One hour access (shock baseline)	0.8	0.9	2.9	1.3	1.7	0.8	-0.3	0.2	-0.4
Social response proportion	1.7	1.8	5.7	1.3	2.4	0.2	0.7	1.1	-1.4
Social responses	1.0	1.3	4.5	1.5	2.1	0.9	-0.4	-0.0	-0.1
Social time	4.2	5.6	7.4	-2.6	-1.7	-2.7	2.6	2.2	-2.3
Soleus weight	2.4	6.9	9.0	3.0	2.1	3.0	-3.0	-2.3	2.2
Bone: stiffness	0.3	0.5	1.0	1.0	1.0	0.8	-0.4	-0.4	0.3
Tibialis anterior weight	4.4	15.1	23.7	4.9	4.5	4.3	-3.6	-3.0	2.5
Time to tail flick, vehicle, before self-admin	1.4	1.4	2.3	-1.5	-1.1	-1.3	1.0	1.2	-0.9
Time to tail flick, vehicle, after self-admin	0.4	0.4	0.5	-0.7	-0.7	-0.6	0.7	0.5	-0.7
Time to tail flick, test, before self-admin	0.5	0.5	1.3	1.0	1.1	0.7	-0.3	0.2	0.1
Time to tail flick, test, after self-admin	0.9	1.0	1.7	0.4	-0.4	0.9	-1.1	-1.3	1.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.3	-0.1	-0.4	0.2	-0.2	-0.6	0.3
Delta time to tail flick, test, before/after SA	1.1	1.0	2.4	-0.1	-1.0	0.6	-0.9	-1.5	1.1
Tibia length	1.5	4.4	14.3	2.9	3.8	1.6	-0.8	-0.4	-0.0
Ambulatory time before self-admin	0.2	0.2	0.4	-0.6	-0.6	-0.4	0.2	0.5	-0.3
Ambulatory time after self-admin	0.2	0.2	0.3	0.5	0.0	0.6	-0.6	-0.4	0.5
Bone: tissue strength	0.1	0.1	0.1	0.3	0.1	0.4	-0.4	-0.2	0.3
Total heroin consumption	1.3	1.5	3.9	-1.9	-2.0	-1.0	0.3	-0.5	0.3
Bone: trabecular number	6.8	10.6	13.8	3.6	2.7	3.7	-3.4	-3.2	2.9
Bone: trabecular spacing	3.2	4.2	6.7	-2.6	-2.3	-2.3	1.8	1.6	-1.4
Bone: trabecular thickness	9.3	11.1	14.6	3.5	2.3	3.8	-3.6	-3.4	3.1
Bone: trabecular tissue density	0.5	0.6	1.0	-0.8	-0.3	-1.0	1.0	0.8	-0.8
Water consumed over 24 hours	1.3	1.6	5.4	1.2	2.3	-0.1	0.9	0.8	-1.2
Number of responses in last shaping day	0.1	0.2	0.3	0.5	0.4	0.1	0.2	0.5	-0.5