Hub : Genes

LOC120095828

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC120095828	0.03	0.02	6.3e-04	0	0.01	0.01	0.01	4.6e-02	5.8e-03	1.6e-02	2.2e-02
2	Brain	gene expression	LOC120095828	0.17	0.11	5.8e-06	0.09	0.07	0.08	0.09	2.2e-08	7.5e-07	4.3e-08	1.0e-08
3	PL	gene expression	LOC120095828	0.03	0.02	8.4e-03	0.02	0.02	0.01	0.02	5.9e-03	6.9e-03	1.5e-02	5.8e-03
4	BLA	gene expression	LOC120095828	0.08	0.05	1.8e-03	0.06	0.04	0.04	0.04	2.8e-04	3.9e-03	2.9e-03	2.3e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	8.7	16.0	19.2	-4.0	-4.4	-3.9	3.8
Area under the delay curve	0.8	1.2	1.9	1.4	1.0	0.9	-1.0
BMI with tail	3.3	11.6	13.3	-3.4	-3.6	-3.2	3.3
BMI without tail	0.5	2.4	6.6	-2.6	-1.5	-0.6	0.4
Body weight	12.2	53.2	75.0	-8.7	-7.4	-6.7	6.2
Weight adjusted by age	0.6	1.6	2.7	-1.6	-1.4	-1.3	0.5
Bone surface	7.6	14.9	16.9	-4.0	-4.1	-3.7	3.6
Bone volume	7.4	14.7	17.8	-3.4	-4.2	-3.9	3.8
Breakpoint value in progressive ratio session	0.1	0.2	0.4	-0.0	0.6	0.4	-0.5
Number of licking bursts	0.3	1.0	2.3	-1.5	-1.0	-0.7	0.2
Context. condit. distance diff. score	2.3	2.8	4.0	-1.6	-1.5	-1.5	2.0
Locomotion velocity, session 1	1.1	1.3	2.4	0.6	1.6	1.3	-0.8
Locomotion distance, session 1	1.0	1.3	1.9	1.0	1.1	1.1	-1.4
Locomotion velocity, session 2	0.3	0.4	0.8	0.0	0.7	0.9	-0.5
Locomotion distance, session 2	0.7	1.0	1.9	0.4	0.9	1.0	-1.4
Locomotion velocity, session 3	0.7	0.8	1.7	-0.6	-0.8	-1.3	0.8
Locomotion distance, session 3	0.0	0.1	0.2	0.2	-0.0	-0.2	-0.4
Stereotopy head waving bouts, day 3	0.2	0.3	1.0	-1.0	-0.2	0.1	-0.2
Stereotopy head waving duration, day 3	0.0	0.1	0.1	0.2	0.2	0.3	-0.3
Locomotion velocity, session 7	0.2	0.2	0.8	0.9	0.3	-0.1	-0.3
Locomotion distance, session 7	0.1	0.1	0.3	0.6	0.2	-0.1	-0.3
Stereotopy head waving bouts, day 7	2.5	2.9	3.7	1.5	1.9	1.7	-1.8
Stereotopy head waving duration, day 7	1.6	2.0	2.8	1.4	1.7	1.3	-1.2
Locomotion velocity, session 8	0.4	0.5	0.7	0.4	0.8	0.8	-0.6
Locomotion distance, session 8	0.7	1.0	1.8	-1.3	-0.9	-0.7	1.0
Degree of sensitization distance	0.5	0.6	0.7	0.8	0.9	0.8	-0.5
Degree of sensitization stereotypy	2.2	2.4	3.5	1.6	1.9	1.4	-1.2
Conditioned locomotion	0.1	0.1	0.1	-0.3	-0.1	0.2	-0.3
Cocaine response after cond. corrected	0.4	0.5	1.0	1.0	0.7	0.6	-0.5
Cocaine response after cond. not corrected	0.4	0.6	1.1	1.0	0.8	0.7	-0.5
Cocaine response before conditioning	0.1	0.1	0.2	-0.4	-0.3	-0.2	0.4
Saline control response	0.5	0.6	2.2	-1.5	-0.4	0.4	-0.2
Bone: connectivity density	9.2	14.6	18.7	-4.3	-4.1	-3.4	3.4
Bone: cortical apparent density	0.0	0.1	0.2	0.3	-0.0	-0.2	0.4
Bone: cortical area	2.7	4.4	5.2	-2.0	-2.3	-2.1	2.0
Bone: cortical porosity	1.6	1.7	2.3	1.0	1.5	1.5	-1.2
Bone: cortical porosity	1.8	2.0	2.4	1.3	1.6	1.6	-1.2
Bone: cortical thickness	2.2	3.6	4.0	-1.9	-2.0	-1.9	1.8
Bone: cortical thickness	0.1	0.1	0.3	-0.5	-0.3	-0.1	-0.4
Bone: cortical tissue density	0.0	0.1	0.1	0.3	0.1	-0.1	0.3
Condit. Reinf. active minus inactive responses	1.5	1.7	2.2	-0.9	-1.5	-1.5	1.3
Condit. Reinf. active-inactive response ratio	1.2	1.3	1.8	-0.7	-1.3	-1.3	1.1
Condit. Reinf. active responses	0.2	0.2	0.4	-0.4	-0.5	-0.6	0.3
Condit. Reinf. inactive responses	0.8	1.1	1.4	0.8	1.2	0.9	-1.2
Incentive salience index mean	0.2	0.3	0.5	-0.3	-0.7	-0.6	0.4
Condit. Reinf. lever presses	0.4	0.5	0.6	0.7	0.6	0.8	-0.8
Condit. Reinf. active minus inactive responses	0.2	0.3	0.5	-0.3	0.5	0.6	-0.7
Condit. Reinf. active-inactive response ratio	0.4	0.7	1.0	0.2	0.9	1.0	-1.0
Condit. Reinf. active responses	0.1	0.2	0.6	-0.8	-0.1	-0.1	-0.2
Condit. Reinf. inactive responses	0.4	0.6	0.8	-0.8	-0.8	-0.9	0.5
Condit. Reinf. lever presses	0.6	0.8	1.2	-0.9	-1.0	-1.1	0.5
Condit. Reinf. lever reinforcers received	0.1	0.2	0.6	-0.8	-0.2	-0.2	-0.1
Conditioned reinforcement - actives	0.1	0.5	1.5	-1.2	-0.1	0.2	0.5
Conditioned reinforcement - inactives	0.1	0.2	0.2	0.4	0.4	0.4	-0.2
Conditioned locomotion	0.3	0.4	0.8	-0.9	0.1	0.7	0.6
Patch foraging indifference point 0 sec	1.6	4.4	6.0	-1.8	-2.4	-2.3	1.8
Patch foraging indifference point AUC	0.3	0.8	1.8	-1.3	-1.0	-0.6	0.4
Delay disc. indifference point, 0s delay	0.4	0.4	0.9	-0.2	-0.5	-0.9	0.7
Delay disc. indifference point, 16s delay	0.3	0.5	1.0	1.0	0.7	0.5	-0.5
Delay disc. indifference point, 2s delay	1.3	1.5	3.3	1.8	1.1	0.9	-0.7
Delay disc. indifference point, 24s delay	0.6	1.0	1.6	1.3	0.7	0.9	-1.1
Delay disc. indifference point, 4s delay	1.2	1.3	2.1	1.5	1.1	0.9	-1.0
Delay disc. indifference point, 8s delay	0.1	0.2	0.3	0.5	0.2	0.3	-0.6
Indifference point function ln k	0.1	0.3	0.6	-0.5	-0.3	-0.5	0.8
Indifference point function log k	0.1	0.3	0.6	-0.5	-0.3	-0.5	0.8
Patch foraging total patch changes 0 sec	1.5	4.4	6.0	-1.8	-2.4	-2.3	1.8
Patch foraging total patch changes 12 sec	3.5	4.7	6.3	-1.9	-2.5	-2.3	1.9
Patch foraging total patch changes 18 sec	0.4	1.0	1.9	-0.9	-1.4	-0.9	0.7
Patch foraging total patch changes 24 sec	0.4	1.3	2.4	-1.1	-1.6	-1.2	0.3
Patch foraging total patch changes 6 sec	0.8	1.4	2.5	-1.2	-1.6	-1.0	0.5
Patch foraging time to switch 0 sec	0.7	2.8	5.4	2.3	1.9	1.1	-1.1
Patch foraging water rate 0 sec	1.4	5.3	9.2	-3.0	-2.4	-1.8	1.7
Patch foraging water rate 12 sec	0.4	1.4	2.6	-1.6	-1.3	-1.0	0.8
Patch foraging water rate 18 sec	0.3	0.7	1.2	0.1	0.8	0.9	-1.1
Patch foraging water rate 24 sec	0.8	1.1	3.7	-1.9	-0.7	-0.1	0.2
Patch foraging water rate 6 sec	1.8	2.7	3.4	-1.8	-1.6	-1.5	1.6
Seeking ratio, delayed vs. immediate footshock	1.1	1.6	2.0	1.4	1.4	1.2	-0.9
Distance traveled before self-admin	0.2	0.3	1.0	1.0	0.5	0.2	-0.2
Distance traveled after self-admin	0.1	0.1	0.3	-0.0	-0.4	-0.5	-0.3
Extensor digitorum longus weight	2.6	10.4	14.5	-3.8	-3.3	-2.8	2.9
Bone: elastic displacement	1.1	1.4	2.5	0.5	1.2	1.6	-1.2
Bone: elastic work	1.6	2.1	4.9	-2.2	-1.5	-0.8	0.9
Bone: endosteal estimation	0.6	1.3	2.4	-1.5	-1.2	-0.9	0.8
Bone: endosteal perimeter	1.2	2.9	3.9	-1.8	-2.0	-1.6	1.3
Epididymis fat weight	1.1	5.8	9.3	-2.0	-2.3	-2.1	3.0
Delta time in closed arm before/after self-admin	0.3	0.3	0.5	-0.6	-0.6	-0.1	0.7
Delta time in open arm before/after self-admin	4.2	5.0	7.3	2.7	2.4	1.6	-2.1
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.0	0.1	-0.1	-0.2
Delay discount exponential model param	1.4	1.9	2.9	-1.7	-1.2	-1.2	1.3
Extinction: sum of active levers before priming	1.0	1.5	2.7	-0.8	-1.5	-1.6	0.9
Active lever presses in extinction session 6	2.8	2.8	4.2	-1.5	-1.6	-2.0	1.5
Bone: final force	1.3	2.2	3.6	-1.9	-1.7	-1.2	0.8
Bone: final moment	1.2	1.9	3.1	-1.8	-1.6	-1.2	0.7
Food consumed during 24 hour testing period	1.0	2.0	2.9	0.8	1.7	1.7	-1.3
Glucose	0.2	0.3	0.9	1.0	0.6	-0.0	0.1
Heart weight	0.6	1.0	1.5	-1.2	-1.0	-0.9	0.9
Delay discount hyperbolic model param	1.2	1.6	2.5	-1.6	-1.1	-1.1	1.2
Intermittent access intake day 1-15 change	0.0	0.2	0.5	-0.7	-0.3	-0.6	0.0
Intermittent access intake escalation	0.1	0.3	0.5	-0.6	-0.4	-0.7	0.2
Intermittent access intake escalation 2	0.0	0.0	0.1	0.0	-0.1	-0.3	0.2
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	-0.3	-0.0	-0.5	0.1
Intermitt. access day 15 inactive lever presses	0.1	0.5	1.8	1.3	0.5	0.3	-0.1
Intermitt. access escalation Index	0.0	0.1	0.3	-0.2	-0.1	-0.3	0.6
Intermittent access day 1 total infusions	1.3	3.9	5.4	1.6	2.2	2.3	-1.6
Intermittent access day 15 total infusions	0.4	1.1	1.9	0.8	1.4	1.1	-0.7
Intermittent access terminal intake (last 3 days)	0.9	1.6	2.7	1.1	1.6	1.5	-0.6
Intermittent access total infusions	1.8	2.1	3.4	1.3	1.9	1.7	-0.7
Intermittent access day 1 locomotion	1.1	1.9	2.9	1.3	1.7	1.7	-0.5
Intermittent access day 15 total locomotion	0.6	2.3	3.1	1.1	1.7	1.8	-1.4
Intermittent access total locomotion	1.6	1.9	2.7	1.3	1.6	1.5	-1.0
Intermittent access standard deviation	0.0	0.1	0.1	0.2	0.3	0.3	0.1
Left kidney weight	5.3	42.2	57.5	-7.6	-6.7	-5.8	5.7
Right kidney weight	5.6	38.9	50.7	-7.1	-6.3	-5.5	5.9
Cocaine induced anxiety	0.1	0.2	0.3	0.5	0.5	0.5	-0.4
Post-drug Anxiety	2.3	2.6	4.5	2.1	1.8	1.3	-1.0
Baseline Anxiety	0.8	1.4	3.4	1.8	1.3	0.7	0.0
Tail length	1.5	8.0	22.4	-4.7	-2.4	-1.7	1.1
Length with tail	8.4	37.1	66.7	-8.2	-5.8	-5.2	4.6
Length without tail	8.3	43.5	51.3	-7.2	-6.6	-6.5	6.1
Times rat made contact with spout	0.2	0.2	0.9	-1.0	-0.2	-0.1	-0.0
Lifetime Intake	1.9	2.4	3.7	1.5	1.9	1.7	-0.7
Liver weight, left	6.3	10.8	12.4	-3.5	-3.5	-3.1	3.0
Liver weight, right	4.4	7.8	11.3	-3.4	-2.9	-2.5	2.3
Locomotor activity	0.7	1.0	2.6	-1.6	-1.0	-0.6	0.4
Locomotor testing distance	0.4	1.1	1.8	-1.3	-1.1	-0.9	0.6
Locomotor testing rearing	0.0	0.1	0.2	-0.1	-0.5	-0.2	0.0
Locomotion in novel chamber	1.5	2.0	3.4	-0.2	1.3	1.8	-1.8
Locomotion in novel chamber post-restriction	0.4	1.1	2.0	-0.7	0.8	1.1	-1.4
Fecal boli incidents, locomotor time 1	0.6	1.5	2.7	-1.6	-0.7	-0.9	1.3
Change in fecal boli incidents, locomotor task	0.6	0.6	0.9	1.0	0.6	0.8	-0.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.7	0.9	0.0	-0.2	0.2
Bouts of movement, locomotor time 1	0.4	0.5	1.1	-1.1	-0.9	-0.1	-0.4
Total resting periods, locomotor time 1	0.5	0.6	1.2	-1.1	-1.0	-0.2	-0.4
Rest time, locomotor task time 1	0.5	0.8	2.0	-0.6	0.5	0.9	-1.4
Distance moved, locomotor task time 1	0.1	0.4	1.2	0.0	-0.3	-0.4	1.1
Vertical activity count, locomotor time 1	0.2	1.6	2.5	-1.0	-1.3	-1.1	1.6
Time >=10cm from walls, locomotor time 2	0.4	1.2	1.6	-0.8	-1.2	-1.3	1.1
Bouts of movement, locomotor time 2	1.3	4.4	6.2	-2.0	-2.5	-2.2	1.5
Total resting periods, locomotor time 2	1.1	4.3	6.1	-2.0	-2.5	-2.2	1.4
Rest time, locomotor task time 2	0.5	0.9	1.9	0.7	0.9	0.6	-1.4
Distance moved, locomotor task time 2	0.7	0.9	1.4	-1.1	-1.2	-0.6	0.8
Vertical activity count, locomotor time 2	1.0	2.4	3.9	-2.0	-1.7	-1.1	1.3
Light reinforcement 1	0.3	1.3	2.9	1.7	1.0	0.9	-0.8
Light reinforcement 2	0.1	0.3	0.7	0.8	0.5	0.5	-0.2
Bone: marrow area	0.5	1.2	2.2	-1.5	-1.2	-0.9	0.7
Bone: maximum diameter	1.7	3.4	4.3	-1.9	-2.1	-1.8	1.6
Bone: maximum force	1.6	3.2	4.4	-2.0	-2.1	-1.7	1.2
Bone: maximum moment	1.5	2.9	4.0	-1.9	-2.0	-1.7	1.1
Mean time between licks in bursts	0.3	1.6	1.9	1.4	1.4	1.3	-1.0
Mean num. licks in bursts	0.2	0.6	0.8	0.9	0.9	0.8	-0.5
Cd content in liver	0.9	1.0	1.4	0.3	1.1	1.2	-1.1
Co content in liver	2.8	3.2	3.9	1.2	2.0	1.9	-2.0
Cu content in liver	0.8	0.9	1.2	-0.9	-0.9	-1.0	1.1
Fe content in liver	8.2	10.1	11.6	-2.8	-3.2	-3.4	3.2
K content in liver	0.3	0.3	0.3	0.6	0.5	0.5	-0.5
Mg content in liver	0.8	0.9	1.1	0.8	1.0	1.0	-0.9
Mn content in liver	0.2	0.2	0.4	0.4	0.6	0.4	-0.2
Na content in liver	0.4	0.5	0.6	-0.7	-0.6	-0.7	0.7
Rb content in liver	1.4	1.6	3.6	1.9	1.0	1.1	-0.9
Se content in liver	1.1	1.4	2.3	-0.8	-1.1	-1.2	1.5
Sr content in liver	0.2	0.2	0.6	-0.8	-0.3	-0.1	0.1
Zn content in liver	2.0	2.4	4.5	-2.1	-1.3	-1.1	1.4
Bone: minimum diameter	0.0	0.0	0.0	0.2	-0.1	-0.1	-0.1
Time in familiar zone, hab. session 1	0.4	0.5	0.9	-0.3	-0.8	-0.9	0.6
Time in novel zone, hab. session 1	0.4	0.4	0.7	-0.8	-0.5	-0.5	0.6
Total zone transitions, hab. session 1	2.0	2.8	3.4	1.1	1.8	1.9	-1.8
Total locomotion distance, hab. session 1	1.1	1.5	2.2	1.3	1.1	1.1	-1.5
Locomotion velocity, hab. session 1	3.0	4.3	4.9	2.2	2.0	1.9	-2.1
Time in familiar zone, hab. session 2	1.8	2.1	3.7	-0.7	-1.2	-1.9	1.6
Time in novel zone, hab. session 2	1.7	1.9	2.9	1.0	1.3	1.7	-1.4
Total zone transitions, hab. session 2	1.2	1.5	2.5	0.3	1.3	1.6	-1.4
Total locomotion distance, hab. session 2	2.5	3.3	4.4	1.5	1.7	1.9	-2.1
Locomotion velocity, hab. session 2	2.7	3.6	4.9	1.5	1.7	2.1	-2.2
Novel to familiar place preference ratio	0.4	0.5	0.9	0.7	0.9	0.7	-0.4
Novelty place preference	0.2	0.3	0.6	0.7	0.7	0.5	-0.1
Time in novel zone, NPP test	0.1	0.1	0.2	0.4	0.5	0.2	0.1
Total zone transitions, NPP test	0.2	0.3	0.7	-0.2	0.3	0.8	-0.7
Total locomotion distance, NPP test	1.6	2.2	2.9	1.3	1.2	1.6	-1.7
Locomotion velocity, NPP test	2.1	3.0	4.5	1.3	1.5	1.9	-2.1
Intraocular pressure	0.4	0.7	1.1	-0.9	-0.7	-0.6	1.0
Delta distance traveled before/after self-admin	0.2	0.2	0.4	-0.7	-0.5	-0.2	-0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.2	-0.2	-0.4	-0.3	-0.4
Parametrial fat weight	0.8	1.9	2.9	-1.1	-1.3	-1.7	1.4
Pavlov. Cond. lever latency	5.0	6.3	6.9	-2.4	-2.5	-2.6	2.5
Pavlov. Cond. magazine entry latency	0.9	1.2	1.8	0.3	1.1	1.4	-1.3
Pavlov. Cond. change in total contacts	0.9	0.9	1.0	0.9	1.0	0.9	-1.0
Pavlov. Cond. index score	2.0	2.5	3.3	1.2	1.6	1.8	-1.7
Pavlov. Cond. latency score	2.7	3.5	4.3	1.4	1.8	2.1	-2.0
Pavlov. Cond. lever contacts	5.3	6.4	6.9	2.4	2.5	2.6	-2.6
Pavlov. Cond. magazine entry number	0.7	0.9	1.4	-0.3	-1.0	-1.2	1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	-0.0	-0.5	-0.7	0.2
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	3.3	1.2	1.6	1.8	-1.6
Pavlov. Cond. response bias	1.7	2.1	3.1	0.9	1.5	1.7	-1.5
Pavlov. Cond. lever latency	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.4
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	1.2	0.9	0.8	-0.2
Pavlov. Cond. change in total contacts	0.0	0.1	0.2	-0.4	-0.1	-0.2	0.3
Pavlov. Cond. index score	0.2	0.3	0.4	0.6	0.6	0.5	-0.5
Pavlov. Cond. latency score	0.2	0.3	0.4	0.6	0.6	0.5	-0.4
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.4	0.2	0.2	-0.5
Pavlov. Cond. magazine entry number	0.4	0.5	1.1	-1.0	-0.7	-0.5	0.3
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.8	-0.9	-0.3	-0.2	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.3	0.6	0.6	0.5	-0.4
Pavlov. Cond. response bias	0.3	0.4	0.7	0.9	0.5	0.5	-0.7
Time in closed arm before self-admin	0.7	1.1	2.9	-1.7	-0.7	-0.3	1.0
Time in closed arm after self-admin	2.5	2.8	5.3	-2.3	-1.3	-0.8	1.9
Time in open arm before self-admin	0.2	0.3	0.6	-0.3	-0.8	-0.7	0.1
Time in open arm after self-admin	3.1	3.4	5.1	2.2	1.6	1.1	-2.3
Bone: periosteal estimation	1.3	3.1	4.0	-2.0	-1.9	-1.6	1.5
Bone: periosteal perimeter	2.1	4.2	5.8	-1.8	-2.4	-2.2	1.8
Bone: post-yield work	0.4	0.7	1.2	-0.6	-1.0	-1.1	0.5
Progressive ratio test 1 active lever presses	0.1	0.2	0.5	-0.4	0.6	0.7	0.1
Progressive ratio test 1 breakpoint	0.1	0.2	0.5	-0.3	0.6	0.7	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.4	0.3	0.6	0.6	-0.6
Progressive ratio test 2 active lever presses	0.5	0.7	1.6	-0.2	1.1	1.3	-0.1
Progressive ratio test 2 breakpoint	0.6	0.7	1.6	-0.1	1.1	1.3	-0.1
Progressive ratio test 2 inactive lever presses	0.1	0.3	0.6	-0.8	0.4	0.5	-0.2
Incentive Sensitization - Responses	0.5	1.5	2.2	1.0	1.5	1.4	-0.8
Incentive Sensitization - Breakpoint	0.6	1.5	2.2	1.0	1.5	1.4	-0.8
Sum of active levers in priming session hrs 5-6	1.1	1.0	1.8	-0.7	-1.2	-1.4	0.6
Progressive ratio	0.3	0.9	1.8	1.3	0.9	0.7	-0.5
Food seeking constrained by brief footshock	0.4	0.4	1.5	-0.2	-0.4	-0.2	1.2
Seeking ratio, punishment vs. effort	0.7	1.5	3.1	-1.7	-0.9	-0.5	1.3
Retroperitoneal fat weight	1.9	8.4	11.1	-1.9	-2.8	-3.3	3.3
Reaction time number correct	0.5	1.6	2.3	-1.5	-1.5	-1.2	0.8
Reaction time mean minus median	0.6	3.8	4.9	1.7	2.2	2.0	-1.9
Reaction time mean minus median AUC	0.6	4.2	4.8	2.1	2.2	2.1	-1.9
Reaction time num false alarms	0.3	0.5	1.2	0.4	0.9	1.1	-0.3
Reaction time num false alarms AUC	0.0	0.1	0.3	0.0	0.3	0.6	0.1
Reaction time trials correct on left	0.5	1.6	2.3	-1.5	-1.5	-1.2	0.8
Reaction time trials on left	0.4	1.5	2.1	-1.5	-1.4	-1.1	0.7
Reaction time mean	3.7	8.1	11.0	3.3	3.2	2.5	-2.2
Reaction time mean AUC	3.2	7.7	10.5	3.2	3.1	2.5	-2.1
Median of all reaction times	4.5	7.0	11.0	3.3	2.9	2.2	-2.0
Reaction time omissions	0.8	1.3	1.9	1.4	1.3	1.0	-0.8
Reaction time false alarm rate	0.3	0.5	0.8	0.6	0.8	0.9	-0.1
Reaction time premature initiation rate	5.0	7.7	10.1	2.2	3.1	3.2	-2.5
Reaction time premature initiations	1.2	3.7	5.2	1.3	2.0	2.3	-1.9
Std. dev. reaction times	1.6	5.3	6.9	2.3	2.6	2.3	-2.0
Reaction time trials completed	0.4	1.5	2.1	-1.5	-1.4	-1.1	0.7
Reaction time trials AUC	0.5	1.6	2.2	-1.5	-1.4	-1.2	0.9
Run reversals in cocaine runway, females	1.4	1.5	2.6	1.6	1.0	1.0	-1.3
Run reversals in cocaine runway, males	1.1	1.2	1.8	-1.1	-1.3	-1.1	0.7
Latency to leave start box in cocaine runway	1.0	1.4	3.3	-0.3	-1.0	-1.8	1.1
Latency to leave start box in cocaine runway, F	1.5	1.9	3.3	-0.7	-1.2	-1.8	1.6
Latency to leave start box in cocaine runway, M	0.4	0.3	1.0	-0.3	-0.6	-1.0	-0.1
Std. dev. time between licks in bursts	0.1	0.1	0.3	0.0	0.5	0.6	0.0
Total sessions with >9 infusions	0.3	0.4	0.8	0.9	0.8	0.5	0.2
Short access day 1 total inactive lever presses	0.1	0.2	0.4	-0.3	0.3	0.1	0.7
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.2	0.1	-0.2	0.1
Short access day 1 total infusions	0.3	0.6	1.3	1.1	1.0	0.5	-0.3
Short access day 10 total infusions	0.8	1.3	2.1	1.3	1.5	1.0	-0.5
Short access total infusions	1.3	1.9	2.7	1.6	1.6	1.3	-0.8
Short access day 1 locomotion	0.6	1.0	1.6	1.1	1.3	0.9	-0.4
Short access day 10 total locomotion	0.1	0.4	1.4	-0.2	-0.0	-0.2	1.2
Short access total locomotion	0.6	0.8	1.3	1.1	1.2	0.9	0.0
One hour access (0.3 mA shock)	2.3	2.8	4.9	0.7	1.8	2.2	-1.6
Compulsive drug intake	0.8	1.2	1.9	1.4	0.7	1.0	-1.2
One hour access (shock baseline)	0.1	0.4	0.8	-0.3	0.7	0.9	-0.3
Social response proportion	0.3	0.4	1.3	-1.1	-0.5	-0.1	-0.1
Social responses	0.2	0.2	0.6	-0.3	0.2	0.5	-0.8
Social time	0.9	1.4	2.7	1.6	1.1	0.9	-1.0
Soleus weight	1.5	4.3	4.6	-2.1	-2.1	-2.0	2.1
Bone: stiffness	0.4	0.8	1.1	-0.9	-1.0	-1.0	0.6
Tibialis anterior weight	2.8	9.7	17.3	-4.2	-3.0	-2.4	2.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.4	0.2	0.7	0.2	-0.0
Time to tail flick, vehicle, after self-admin	1.1	2.3	3.1	-1.1	-1.6	-1.8	1.5
Time to tail flick, test, before self-admin	2.3	2.6	3.8	-2.0	-1.5	-1.3	1.7
Time to tail flick, test, after self-admin	0.5	0.6	1.9	0.2	0.1	-0.6	1.4
Delta time to tail flick, vehicle, before/after SA	2.5	2.7	4.0	-0.7	-1.9	-2.0	1.6
Delta time to tail flick, test, before/after SA	1.0	1.2	2.3	1.5	1.2	0.7	-0.7
Tibia length	4.1	11.3	15.7	-4.0	-3.6	-3.0	2.8
Ambulatory time before self-admin	0.1	0.2	0.4	0.6	0.4	0.1	-0.2
Ambulatory time after self-admin	0.0	0.1	0.1	-0.0	-0.2	-0.4	-0.2
Bone: tissue strength	1.3	1.3	1.7	-1.2	-1.1	-1.0	1.3
Total heroin consumption	2.2	2.6	4.1	2.0	1.7	1.1	-1.5
Bone: trabecular number	7.1	13.3	16.2	-3.8	-4.0	-3.4	3.3
Bone: trabecular spacing	1.0	1.5	3.0	1.7	1.4	0.8	-0.6
Bone: trabecular thickness	5.7	7.9	9.5	-2.8	-3.1	-2.8	2.7
Bone: trabecular tissue density	0.2	0.3	0.6	0.4	0.1	-0.6	0.7
Water consumed over 24 hours	0.2	0.4	1.4	-1.2	-0.4	0.0	-0.2
Number of responses in last shaping day	0.0	0.0	0.1	0.1	-0.0	-0.1	0.3