Hub : Genes

LOC120095199

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression LOC120095199 0.18 0.09 3.8e-06 0.08 0.13 0.09 0.09 2.0e-04 4.5e-06 9.4e-05 8.7e-05
2 Liver gene expression LOC120095199 0.09 0.05 1.3e-08 0.06 0.06 0.06 0.06 2.0e-07 9.3e-07 2.5e-07 4.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.00.10.10.2-0.2
Area under the delay curve0.30.40.5-0.50.7
BMI with tail2.06.69.1-3.02.0
BMI without tail2.75.57.2-2.71.9
Body weight4.820.022.8-4.84.2
Weight adjusted by age0.10.20.3-0.50.2
Bone surface0.71.31.6-1.01.3
Bone volume1.32.22.3-1.41.5
Breakpoint value in progressive ratio session0.00.00.00.2-0.0
Number of licking bursts0.80.91.3-0.81.1
Context. condit. distance diff. score0.20.30.3-0.50.5
Locomotion velocity, session 10.00.00.0-0.1-0.1
Locomotion distance, session 10.00.10.1-0.2-0.3
Locomotion velocity, session 20.60.71.00.6-1.0
Locomotion distance, session 20.60.91.40.6-1.2
Locomotion velocity, session 30.91.11.70.7-1.3
Locomotion distance, session 30.00.00.0-0.1-0.0
Stereotopy head waving bouts, day 38.29.710.23.0-3.2
Stereotopy head waving duration, day 33.74.44.62.1-2.1
Locomotion velocity, session 70.20.30.40.4-0.6
Locomotion distance, session 70.81.01.0-1.01.0
Stereotopy head waving bouts, day 73.43.84.41.8-2.1
Stereotopy head waving duration, day 76.68.08.62.7-2.9
Locomotion velocity, session 80.00.00.0-0.1-0.0
Locomotion distance, session 80.00.10.1-0.2-0.3
Degree of sensitization distance0.40.40.5-0.50.7
Degree of sensitization stereotypy1.31.41.91.0-1.4
Conditioned locomotion0.00.00.00.2-0.1
Cocaine response after cond. corrected0.60.71.0-0.61.0
Cocaine response after cond. not corrected0.80.91.3-0.71.1
Cocaine response before conditioning0.00.00.00.1-0.2
Saline control response0.60.81.5-1.20.4
Bone: connectivity density1.42.32.31.5-1.5
Bone: cortical apparent density2.73.54.01.7-2.0
Bone: cortical area1.62.33.4-1.81.2
Bone: cortical porosity2.83.03.0-1.71.7
Bone: cortical porosity4.65.05.3-2.32.2
Bone: cortical thickness1.22.03.50.7-1.9
Bone: cortical thickness2.73.14.61.3-2.1
Bone: cortical tissue density2.63.43.91.7-2.0
Condit. Reinf. active minus inactive responses4.95.55.7-2.32.4
Condit. Reinf. active-inactive response ratio1.11.21.7-0.91.3
Condit. Reinf. active responses3.84.74.9-2.22.1
Condit. Reinf. inactive responses0.40.50.8-0.90.4
Incentive salience index mean2.22.72.7-1.71.6
Condit. Reinf. lever presses0.20.20.3-0.60.3
Condit. Reinf. active minus inactive responses3.54.44.5-2.12.1
Condit. Reinf. active-inactive response ratio3.53.74.3-1.72.1
Condit. Reinf. active responses4.05.65.8-2.42.3
Condit. Reinf. inactive responses0.20.30.6-0.70.2
Condit. Reinf. lever presses3.04.14.8-2.21.8
Condit. Reinf. lever reinforcers received4.05.75.8-2.42.4
Conditioned reinforcement - actives3.23.23.61.7-1.9
Conditioned reinforcement - inactives0.20.20.4-0.60.2
Conditioned locomotion1.21.41.8-1.31.0
Patch foraging indifference point 0 sec4.47.18.5-2.92.4
Patch foraging indifference point AUC0.70.80.8-0.90.9
Delay disc. indifference point, 0s delay0.10.10.1-0.00.4
Delay disc. indifference point, 16s delay0.50.50.5-0.70.7
Delay disc. indifference point, 2s delay0.00.00.0-0.10.1
Delay disc. indifference point, 24s delay1.81.71.8-1.31.3
Delay disc. indifference point, 4s delay0.00.00.00.10.0
Delay disc. indifference point, 8s delay0.10.10.20.5-0.2
Indifference point function ln k1.41.92.71.0-1.7
Indifference point function log k1.41.92.71.0-1.7
Patch foraging total patch changes 0 sec3.76.07.3-2.72.2
Patch foraging total patch changes 12 sec4.15.25.4-2.32.2
Patch foraging total patch changes 18 sec2.22.83.5-1.91.5
Patch foraging total patch changes 24 sec4.55.56.3-2.52.2
Patch foraging total patch changes 6 sec8.612.713.5-3.73.4
Patch foraging time to switch 0 sec0.20.20.4-0.20.7
Patch foraging water rate 0 sec0.61.01.5-1.20.8
Patch foraging water rate 12 sec0.10.10.1-0.4-0.2
Patch foraging water rate 18 sec0.50.60.90.5-1.0
Patch foraging water rate 24 sec0.71.01.20.9-1.1
Patch foraging water rate 6 sec0.71.11.60.8-1.3
Seeking ratio, delayed vs. immediate footshock1.72.02.3-1.31.5
Distance traveled before self-admin0.00.00.00.20.1
Distance traveled after self-admin0.00.00.0-0.2-0.1
Extensor digitorum longus weight0.10.20.3-0.50.4
Bone: elastic displacement1.51.72.41.0-1.5
Bone: elastic work0.10.10.2-0.1-0.5
Bone: endosteal estimation12.326.831.0-4.75.6
Bone: endosteal perimeter12.726.429.4-4.85.4
Epididymis fat weight2.96.86.9-2.62.6
Delta time in closed arm before/after self-admin0.10.10.20.4-0.0
Delta time in open arm before/after self-admin2.92.82.91.6-1.7
Diff in mean of infusions in LGA sessions0.10.10.2-0.50.1
Delay discount exponential model param0.70.81.00.7-1.0
Extinction: sum of active levers before priming1.01.01.7-0.51.3
Active lever presses in extinction session 60.10.10.2-0.50.1
Bone: final force0.81.21.4-1.21.0
Bone: final moment0.61.01.2-1.10.9
Food consumed during 24 hour testing period0.10.10.1-0.3-0.4
Glucose0.00.00.0-0.00.0
Heart weight4.15.87.3-2.72.1
Delay discount hyperbolic model param0.40.50.60.6-0.8
Intermittent access intake day 1-15 change1.91.92.3-1.21.5
Intermittent access intake escalation1.81.82.2-1.11.5
Intermittent access intake escalation 23.02.93.9-1.42.0
Intermitt. access day 1 inactive lever presses1.51.71.7-1.31.3
Intermitt. access day 15 inactive lever presses0.50.60.7-0.80.7
Intermitt. access escalation Index0.40.40.60.7-0.5
Intermittent access day 1 total infusions0.10.20.30.1-0.6
Intermittent access day 15 total infusions1.41.61.7-1.31.3
Intermittent access terminal intake (last 3 days)1.51.61.6-1.31.3
Intermittent access total infusions0.40.40.5-0.70.6
Intermittent access day 1 locomotion2.32.42.5-1.61.5
Intermittent access day 15 total locomotion2.62.72.8-1.71.6
Intermittent access total locomotion5.05.76.2-2.52.3
Intermittent access standard deviation2.72.93.2-1.61.8
Left kidney weight0.72.12.7-1.71.2
Right kidney weight1.85.05.6-2.42.1
Cocaine induced anxiety0.40.40.60.7-0.5
Post-drug Anxiety0.40.40.60.8-0.5
Baseline Anxiety0.80.81.00.8-1.0
Tail length1.44.25.1-1.82.3
Length with tail2.59.010.3-2.83.2
Length without tail0.30.70.9-0.81.0
Times rat made contact with spout0.30.40.6-0.80.4
Lifetime Intake0.20.20.4-0.60.3
Liver weight, left0.50.81.01.0-0.8
Liver weight, right0.91.51.81.3-1.1
Locomotor activity1.21.93.2-1.80.8
Locomotor testing distance1.01.73.2-1.80.5
Locomotor testing rearing0.91.42.4-1.60.5
Locomotion in novel chamber0.10.10.30.1-0.5
Locomotion in novel chamber post-restriction0.00.00.00.1-0.1
Fecal boli incidents, locomotor time 10.80.91.5-0.61.2
Change in fecal boli incidents, locomotor task0.20.20.20.3-0.5
Time >=10cm from walls, locomotor time 11.71.72.41.0-1.5
Bouts of movement, locomotor time 10.50.50.5-0.70.7
Total resting periods, locomotor time 10.50.60.8-0.60.9
Rest time, locomotor task time 10.10.20.20.50.3
Distance moved, locomotor task time 10.30.30.60.2-0.8
Vertical activity count, locomotor time 10.10.10.10.1-0.4
Time >=10cm from walls, locomotor time 20.90.91.50.6-1.2
Bouts of movement, locomotor time 20.30.30.6-0.80.2
Total resting periods, locomotor time 20.30.30.6-0.80.2
Rest time, locomotor task time 22.02.33.61.9-1.0
Distance moved, locomotor task time 20.30.30.60.2-0.8
Vertical activity count, locomotor time 20.40.40.8-0.90.3
Light reinforcement 10.30.51.00.2-1.0
Light reinforcement 20.00.00.00.00.2
Bone: marrow area11.825.629.9-4.65.5
Bone: maximum diameter3.15.86.2-2.32.5
Bone: maximum force2.13.64.0-2.01.8
Bone: maximum moment1.93.33.7-1.91.7
Mean time between licks in bursts2.12.93.1-1.61.8
Mean num. licks in bursts0.30.40.70.3-0.8
Cd content in liver1.51.62.31.5-1.0
Co content in liver0.10.10.1-0.10.3
Cu content in liver0.00.00.00.10.0
Fe content in liver0.00.00.10.2-0.3
K content in liver0.90.90.91.0-0.9
Mg content in liver4.14.24.42.1-2.0
Mn content in liver3.03.43.61.8-1.9
Na content in liver1.11.21.41.0-1.2
Rb content in liver1.92.32.81.7-1.3
Se content in liver1.41.71.81.3-1.3
Sr content in liver1.51.41.7-1.31.0
Zn content in liver0.70.80.80.9-0.9
Bone: minimum diameter11.621.722.2-4.64.7
Time in familiar zone, hab. session 12.01.92.3-1.21.5
Time in novel zone, hab. session 11.01.01.30.8-1.1
Total zone transitions, hab. session 10.30.40.7-0.80.2
Total locomotion distance, hab. session 10.10.10.1-0.3-0.4
Locomotion velocity, hab. session 10.10.10.1-0.2-0.4
Time in familiar zone, hab. session 21.91.92.1-1.31.4
Time in novel zone, hab. session 23.93.94.11.9-2.0
Total zone transitions, hab. session 20.10.10.2-0.5-0.2
Total locomotion distance, hab. session 20.20.30.60.1-0.8
Locomotion velocity, hab. session 20.50.71.20.4-1.1
Novel to familiar place preference ratio3.83.93.9-2.02.0
Novelty place preference2.62.62.6-1.61.6
Time in novel zone, NPP test2.12.22.3-1.51.4
Total zone transitions, NPP test0.30.40.80.2-0.9
Total locomotion distance, NPP test0.81.11.70.7-1.3
Locomotion velocity, NPP test0.40.51.00.3-1.0
Intraocular pressure0.71.01.4-1.20.8
Delta distance traveled before/after self-admin1.01.01.80.5-1.3
Delta ambulatory time before/after self-admin0.10.20.30.1-0.6
Parametrial fat weight0.71.51.71.3-1.1
Pavlov. Cond. lever latency1.72.22.81.7-1.2
Pavlov. Cond. magazine entry latency1.92.42.6-1.61.5
Pavlov. Cond. change in total contacts2.83.03.5-1.91.6
Pavlov. Cond. index score2.22.83.3-1.81.5
Pavlov. Cond. latency score2.43.13.7-1.91.6
Pavlov. Cond. lever contacts1.82.12.7-1.71.2
Pavlov. Cond. magazine entry number1.11.31.51.2-1.1
Pavlov. Cond. intertrial magazine entries4.55.46.1-2.52.2
Pavlov. Cond. lever-magazine prob. diff.1.92.42.9-1.71.4
Pavlov. Cond. response bias1.21.41.7-1.31.0
Pavlov. Cond. lever latency0.30.40.50.7-0.5
Pavlov. Cond. magazine entry latency0.00.00.00.00.1
Pavlov. Cond. change in total contacts0.30.50.5-0.70.6
Pavlov. Cond. index score0.70.90.9-1.00.9
Pavlov. Cond. latency score0.60.70.8-0.90.8
Pavlov. Cond. lever contacts0.20.20.4-0.60.2
Pavlov. Cond. magazine entry number0.00.00.00.1-0.0
Pavlov. Cond. intertrial magazine entries0.20.20.2-0.50.5
Pavlov. Cond. lever-magazine prob. diff.0.60.70.8-0.90.8
Pavlov. Cond. response bias0.20.20.3-0.50.4
Time in closed arm before self-admin0.00.00.0-0.20.1
Time in closed arm after self-admin0.20.20.2-0.30.5
Time in open arm before self-admin0.91.01.2-1.10.9
Time in open arm after self-admin0.00.10.1-0.30.1
Bone: periosteal estimation8.818.218.9-4.24.4
Bone: periosteal perimeter7.813.013.2-3.63.6
Bone: post-yield work3.24.44.7-2.02.2
Progressive ratio test 1 active lever presses0.10.10.2-0.5-0.1
Progressive ratio test 1 breakpoint0.30.30.5-0.70.1
Progressive ratio test 1 inactive lever presses1.41.52.5-1.60.8
Progressive ratio test 2 active lever presses0.00.00.1-0.1-0.2
Progressive ratio test 2 breakpoint0.10.10.10.0-0.3
Progressive ratio test 2 inactive lever presses0.10.10.2-0.4-0.1
Incentive Sensitization - Responses0.20.20.20.5-0.5
Incentive Sensitization - Breakpoint0.30.30.30.5-0.5
Sum of active levers in priming session hrs 5-61.01.01.6-0.61.3
Progressive ratio0.00.00.00.2-0.0
Food seeking constrained by brief footshock0.30.30.5-0.40.7
Seeking ratio, punishment vs. effort0.10.10.1-0.40.3
Retroperitoneal fat weight2.78.79.8-3.12.8
Reaction time number correct0.71.01.11.0-1.0
Reaction time mean minus median0.10.10.10.20.3
Reaction time mean minus median AUC0.30.30.60.8-0.3
Reaction time num false alarms2.93.95.6-2.41.5
Reaction time num false alarms AUC2.83.95.4-2.31.5
Reaction time trials correct on left0.71.01.11.0-1.0
Reaction time trials on left0.71.01.01.0-1.0
Reaction time mean0.40.61.11.1-0.3
Reaction time mean AUC0.50.71.31.1-0.4
Median of all reaction times0.50.71.21.1-0.3
Reaction time omissions0.00.00.00.20.2
Reaction time false alarm rate3.34.66.0-2.51.8
Reaction time premature initiation rate3.44.65.2-2.32.0
Reaction time premature initiations1.11.51.9-1.41.1
Std. dev. reaction times0.30.40.70.9-0.1
Reaction time trials completed0.71.01.01.0-1.0
Reaction time trials AUC0.81.21.21.1-1.1
Run reversals in cocaine runway, females1.11.01.3-1.10.9
Run reversals in cocaine runway, males0.00.00.00.2-0.1
Latency to leave start box in cocaine runway1.31.41.81.0-1.3
Latency to leave start box in cocaine runway, F0.20.20.40.1-0.7
Latency to leave start box in cocaine runway, M1.81.72.01.4-1.2
Std. dev. time between licks in bursts0.40.50.60.6-0.8
Total sessions with >9 infusions0.10.10.1-0.2-0.3
Short access day 1 total inactive lever presses0.00.00.10.0-0.3
Short access day 10 total inactive lever presses1.21.41.7-1.01.3
Short access day 1 total infusions0.60.61.10.2-1.1
Short access day 10 total infusions1.41.62.1-1.51.0
Short access total infusions0.20.20.4-0.60.0
Short access day 1 locomotion0.30.30.6-0.8-0.0
Short access day 10 total locomotion5.66.26.2-2.52.5
Short access total locomotion3.33.54.3-2.11.6
One hour access (0.3 mA shock)0.40.50.5-0.70.7
Compulsive drug intake1.21.21.7-0.81.3
One hour access (shock baseline)0.00.00.1-0.2-0.3
Social response proportion0.80.81.0-0.81.0
Social responses1.82.42.8-1.71.4
Social time0.50.60.8-0.70.9
Soleus weight1.02.93.0-1.71.7
Bone: stiffness1.42.32.3-1.51.5
Tibialis anterior weight0.72.32.6-1.61.4
Time to tail flick, vehicle, before self-admin0.30.30.50.10.7
Time to tail flick, vehicle, after self-admin0.70.71.3-0.41.1
Time to tail flick, test, before self-admin1.81.82.1-1.21.5
Time to tail flick, test, after self-admin1.21.21.9-0.81.4
Delta time to tail flick, vehicle, before/after SA0.00.00.00.20.0
Delta time to tail flick, test, before/after SA0.20.20.30.10.6
Tibia length1.13.13.3-1.81.7
Ambulatory time before self-admin0.00.00.00.2-0.2
Ambulatory time after self-admin0.00.00.0-0.1-0.2
Bone: tissue strength2.92.83.41.5-1.8
Total heroin consumption0.20.20.4-0.30.6
Bone: trabecular number0.50.90.91.0-0.9
Bone: trabecular spacing0.00.00.1-0.20.2
Bone: trabecular thickness0.91.11.1-1.01.0
Bone: trabecular tissue density0.00.00.00.1-0.1
Water consumed over 24 hours0.60.71.30.5-1.1
Number of responses in last shaping day0.10.10.2-0.5-0.2