Hub : Genes

LOC120095199

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression LOC120095199 0.12 0.07 4.6e-07 0.09 0.08 0.07 0.07 8.6e-08 1.1e-06 1.3e-06 1.4e-06
2 pVTA intron excision ratio chr10_94368168_94377498 0.12 0.07 2.4e-05 0.03 0.05 0.04 0.04 2.5e-03 4.1e-05 3.5e-04 4.4e-04
3 Liver gene expression LOC120095199 0.14 0.08 3.5e-11 0.07 0.07 0.08 0.07 1.8e-08 9.8e-09 9.1e-09 2.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.20.30.8-0.2-0.0-0.9
Area under the delay curve0.00.10.10.1-0.3-0.3
BMI with tail3.411.914.22.9-3.63.8
BMI without tail2.412.618.52.9-3.24.3
Body weight9.139.946.76.0-6.16.8
Weight adjusted by age0.10.20.20.3-0.50.5
Bone surface0.50.91.71.3-1.0-0.2
Bone volume0.71.52.31.5-1.40.1
Breakpoint value in progressive ratio session0.30.61.0-1.00.80.1
Number of licking bursts0.31.01.31.2-0.71.0
Context. condit. distance diff. score0.30.30.60.5-0.80.3
Locomotion velocity, session 10.00.00.0-0.10.20.2
Locomotion distance, session 10.00.00.1-0.30.20.0
Locomotion velocity, session 21.01.11.7-1.01.3-0.9
Locomotion distance, session 20.91.31.6-1.21.3-0.9
Locomotion velocity, session 31.61.82.1-1.31.5-1.2
Locomotion distance, session 30.10.10.3-0.00.1-0.6
Stereotopy head waving bouts, day 37.48.810.1-3.23.0-2.7
Stereotopy head waving duration, day 33.64.45.1-2.22.3-1.8
Locomotion velocity, session 70.20.20.4-0.50.1-0.6
Locomotion distance, session 70.40.51.01.0-0.8-0.0
Stereotopy head waving bouts, day 72.93.35.1-2.31.9-1.2
Stereotopy head waving duration, day 74.86.08.6-2.92.6-1.6
Locomotion velocity, session 80.00.00.0-0.00.1-0.2
Locomotion distance, session 80.20.20.5-0.30.3-0.7
Degree of sensitization distance0.20.20.50.7-0.50.1
Degree of sensitization stereotypy0.91.02.1-1.40.9-0.2
Conditioned locomotion0.20.30.6-0.10.5-0.8
Cocaine response after cond. corrected0.40.61.11.0-0.8-0.0
Cocaine response after cond. not corrected0.50.71.51.2-0.80.2
Cocaine response before conditioning0.10.10.1-0.10.4-0.2
Saline control response1.11.53.00.7-0.91.7
Bone: connectivity density1.83.04.3-1.61.5-2.1
Bone: cortical apparent density2.13.34.8-2.22.0-1.1
Bone: cortical area0.30.40.70.8-0.70.2
Bone: cortical porosity1.31.52.81.7-1.10.7
Bone: cortical porosity2.83.04.52.1-1.71.3
Bone: cortical thickness1.62.74.7-2.21.6-0.9
Bone: cortical thickness3.03.75.5-2.31.7-1.7
Bone: cortical tissue density2.13.34.7-2.22.0-1.0
Condit. Reinf. active minus inactive responses3.23.65.72.4-1.61.6
Condit. Reinf. active-inactive response ratio1.11.21.81.3-0.81.1
Condit. Reinf. active responses1.92.44.32.1-1.50.8
Condit. Reinf. inactive responses0.20.20.40.4-0.4-0.6
Incentive salience index mean1.31.62.61.6-1.01.1
Condit. Reinf. lever presses0.00.10.20.1-0.10.4
Condit. Reinf. active minus inactive responses1.21.94.12.0-1.10.6
Condit. Reinf. active-inactive response ratio1.42.24.02.0-1.31.0
Condit. Reinf. active responses1.72.45.22.3-1.30.5
Condit. Reinf. inactive responses0.20.30.80.20.2-0.9
Condit. Reinf. lever presses1.31.83.01.7-1.21.0
Condit. Reinf. lever reinforcers received1.82.55.22.3-1.40.7
Conditioned reinforcement - actives0.10.40.80.5-0.4-0.9
Conditioned reinforcement - inactives0.71.82.71.5-1.60.8
Conditioned locomotion2.23.24.22.1-2.01.1
Patch foraging indifference point 0 sec1.43.85.82.4-1.71.7
Patch foraging indifference point AUC0.40.91.51.2-0.90.7
Delay disc. indifference point, 0s delay0.00.00.0-0.1-0.20.0
Delay disc. indifference point, 16s delay0.30.40.40.6-0.70.6
Delay disc. indifference point, 2s delay0.50.61.4-0.40.5-1.2
Delay disc. indifference point, 24s delay1.22.02.51.3-1.61.3
Delay disc. indifference point, 4s delay0.30.40.7-0.50.3-0.9
Delay disc. indifference point, 8s delay0.10.20.4-0.60.2-0.6
Indifference point function ln k1.03.03.4-1.61.8-1.8
Indifference point function log k1.03.03.4-1.61.8-1.8
Patch foraging total patch changes 0 sec1.02.84.42.1-1.41.4
Patch foraging total patch changes 12 sec2.53.34.92.2-1.71.5
Patch foraging total patch changes 18 sec0.71.71.81.4-1.11.4
Patch foraging total patch changes 24 sec0.93.03.41.8-1.81.5
Patch foraging total patch changes 6 sec4.98.310.63.3-2.82.6
Patch foraging time to switch 0 sec0.20.81.50.4-0.81.2
Patch foraging water rate 0 sec0.00.20.40.7-0.1-0.2
Patch foraging water rate 12 sec0.00.10.3-0.20.10.5
Patch foraging water rate 18 sec0.30.71.1-1.10.6-0.8
Patch foraging water rate 24 sec1.21.72.5-1.11.2-1.6
Patch foraging water rate 6 sec1.42.12.3-1.41.4-1.5
Seeking ratio, delayed vs. immediate footshock0.50.81.41.2-0.90.2
Distance traveled before self-admin1.02.12.4-1.61.6-1.2
Distance traveled after self-admin0.10.10.3-0.30.60.1
Extensor digitorum longus weight0.72.84.10.5-2.02.0
Bone: elastic displacement1.82.32.9-1.71.7-1.1
Bone: elastic work0.10.10.2-0.50.40.1
Bone: endosteal estimation8.420.532.05.7-4.72.8
Bone: endosteal perimeter7.919.430.45.5-4.62.6
Epididymis fat weight3.216.021.93.2-4.04.7
Delta time in closed arm before/after self-admin0.30.30.9-0.20.0-0.9
Delta time in open arm before/after self-admin1.21.41.8-1.31.3-0.9
Diff in mean of infusions in LGA sessions0.10.20.6-0.8-0.00.2
Delay discount exponential model param0.10.20.3-0.40.50.2
Extinction: sum of active levers before priming0.60.91.20.9-0.91.1
Active lever presses in extinction session 60.00.00.10.1-0.20.2
Bone: final force0.20.30.50.7-0.60.2
Bone: final moment0.10.20.30.6-0.40.1
Food consumed during 24 hour testing period0.10.20.6-0.3-0.00.8
Glucose0.00.10.20.1-0.40.1
Heart weight1.22.02.21.4-1.41.5
Delay discount hyperbolic model param0.10.10.2-0.30.40.3
Intermittent access intake day 1-15 change1.36.97.92.8-2.82.2
Intermittent access intake escalation1.26.47.62.8-2.62.2
Intermittent access intake escalation 23.45.87.32.7-2.61.8
Intermitt. access day 1 inactive lever presses0.45.35.72.2-2.42.3
Intermitt. access day 15 inactive lever presses0.84.45.81.7-2.12.4
Intermitt. access escalation Index0.30.91.1-1.01.0-0.9
Intermittent access day 1 total infusions0.00.00.10.20.1-0.2
Intermittent access day 15 total infusions1.94.75.92.4-2.31.6
Intermittent access terminal intake (last 3 days)2.95.16.62.6-2.61.5
Intermittent access total infusions1.51.82.81.7-1.40.8
Intermittent access day 1 locomotion2.54.65.12.2-2.31.9
Intermittent access day 15 total locomotion1.76.57.42.6-2.72.3
Intermittent access total locomotion8.09.610.43.2-3.12.9
Intermittent access standard deviation1.99.711.83.2-3.42.6
Left kidney weight0.21.52.70.9-1.01.7
Right kidney weight0.42.74.51.1-1.52.1
Cocaine induced anxiety0.10.20.6-0.4-0.1-0.7
Post-drug Anxiety1.01.21.8-1.30.6-1.1
Baseline Anxiety1.52.52.7-1.61.6-1.4
Tail length1.36.89.72.6-1.93.1
Length with tail4.218.824.34.3-3.74.9
Length without tail1.89.39.82.9-3.13.1
Times rat made contact with spout0.40.51.00.4-0.51.0
Lifetime Intake0.81.01.81.3-1.00.4
Liver weight, left1.42.43.41.8-1.51.2
Liver weight, right0.20.30.80.1-0.30.9
Locomotor activity0.81.21.31.0-1.11.2
Locomotor testing distance0.30.60.90.6-0.71.0
Locomotor testing rearing0.10.40.50.6-0.70.7
Locomotion in novel chamber0.50.60.9-0.80.6-0.9
Locomotion in novel chamber post-restriction0.00.00.1-0.00.3-0.1
Fecal boli incidents, locomotor time 10.61.52.51.6-1.20.8
Change in fecal boli incidents, locomotor task0.80.81.2-0.70.9-1.1
Time >=10cm from walls, locomotor time 10.40.50.9-0.71.0-0.5
Bouts of movement, locomotor time 10.70.91.20.7-1.10.9
Total resting periods, locomotor time 10.91.11.40.9-1.21.0
Rest time, locomotor task time 10.10.10.20.5-0.30.2
Distance moved, locomotor task time 10.10.40.8-0.90.5-0.2
Vertical activity count, locomotor time 10.00.10.2-0.40.10.1
Time >=10cm from walls, locomotor time 20.20.40.9-1.00.60.2
Bouts of movement, locomotor time 20.20.60.9-0.0-0.90.9
Total resting periods, locomotor time 20.20.61.00.1-0.91.0
Rest time, locomotor task time 20.61.11.4-0.91.2-0.9
Distance moved, locomotor task time 20.20.30.9-0.90.20.2
Vertical activity count, locomotor time 20.40.81.50.5-0.81.2
Light reinforcement 10.10.60.8-0.90.9-0.4
Light reinforcement 20.10.20.50.30.30.7
Bone: marrow area8.019.730.65.5-4.62.7
Bone: maximum diameter1.63.15.92.4-1.70.7
Bone: maximum force0.91.72.41.6-1.50.6
Bone: maximum moment0.81.52.31.5-1.40.5
Mean time between licks in bursts0.85.16.01.8-2.42.4
Mean num. licks in bursts0.10.40.7-0.90.4-0.4
Cd content in liver0.10.10.1-0.4-0.20.0
Co content in liver0.10.10.2-0.3-0.30.5
Cu content in liver0.10.10.20.5-0.20.3
Fe content in liver0.00.10.10.40.1-0.1
K content in liver1.01.01.9-0.71.4-0.7
Mg content in liver3.23.53.9-1.82.0-1.9
Mn content in liver4.65.17.1-2.12.7-2.0
Na content in liver0.80.91.3-0.81.2-0.8
Rb content in liver1.31.52.9-1.11.7-0.4
Se content in liver1.31.53.2-1.11.8-0.4
Sr content in liver1.21.01.80.8-0.81.3
Zn content in liver0.10.10.2-0.10.3-0.5
Bone: minimum diameter7.814.922.54.7-3.92.6
Time in familiar zone, hab. session 11.61.82.71.6-1.50.7
Time in novel zone, hab. session 11.01.11.6-1.21.3-0.4
Total zone transitions, hab. session 10.30.51.10.3-0.51.1
Total locomotion distance, hab. session 10.10.20.3-0.40.20.5
Locomotion velocity, hab. session 10.10.20.3-0.40.30.5
Time in familiar zone, hab. session 21.21.42.11.5-1.20.7
Time in novel zone, hab. session 23.13.44.2-2.12.0-1.4
Total zone transitions, hab. session 20.10.20.5-0.20.00.7
Total locomotion distance, hab. session 20.20.30.7-0.80.50.0
Locomotion velocity, hab. session 20.50.61.2-1.10.8-0.2
Novel to familiar place preference ratio2.63.44.02.0-1.81.8
Novelty place preference1.92.52.61.6-1.61.6
Time in novel zone, NPP test1.61.92.01.4-1.41.3
Total zone transitions, NPP test0.40.60.9-1.00.9-0.2
Total locomotion distance, NPP test1.01.42.0-1.41.4-0.7
Locomotion velocity, NPP test0.50.81.2-1.11.1-0.2
Intraocular pressure0.10.20.40.7-0.40.1
Delta distance traveled before/after self-admin0.10.10.30.4-0.00.5
Delta ambulatory time before/after self-admin0.30.50.80.9-0.50.7
Parametrial fat weight0.40.82.0-0.30.6-1.4
Pavlov. Cond. lever latency1.41.72.8-1.21.0-1.7
Pavlov. Cond. magazine entry latency1.31.72.01.3-1.21.4
Pavlov. Cond. change in total contacts2.32.53.71.5-1.21.9
Pavlov. Cond. index score1.72.12.41.5-1.31.6
Pavlov. Cond. latency score1.92.43.01.6-1.41.7
Pavlov. Cond. lever contacts1.61.92.91.2-1.21.7
Pavlov. Cond. magazine entry number1.21.51.7-1.21.1-1.3
Pavlov. Cond. intertrial magazine entries2.02.44.22.1-1.50.8
Pavlov. Cond. lever-magazine prob. diff.1.21.51.71.3-1.11.3
Pavlov. Cond. response bias0.91.11.61.0-0.81.3
Pavlov. Cond. lever latency0.10.10.3-0.50.10.1
Pavlov. Cond. magazine entry latency0.00.10.10.2-0.3-0.2
Pavlov. Cond. change in total contacts0.10.10.40.6-0.2-0.0
Pavlov. Cond. index score0.20.40.70.8-0.70.2
Pavlov. Cond. latency score0.20.20.50.7-0.5-0.0
Pavlov. Cond. lever contacts0.00.00.10.30.0-0.2
Pavlov. Cond. magazine entry number0.00.10.20.20.10.4
Pavlov. Cond. intertrial magazine entries0.10.30.40.6-0.6-0.1
Pavlov. Cond. lever-magazine prob. diff.0.20.30.60.7-0.60.0
Pavlov. Cond. response bias0.10.10.10.4-0.2-0.2
Time in closed arm before self-admin0.20.40.6-0.40.60.7
Time in closed arm after self-admin0.10.10.2-0.1-0.10.4
Time in open arm before self-admin2.12.64.11.5-2.01.1
Time in open arm after self-admin0.20.30.50.7-0.50.2
Bone: periosteal estimation4.811.418.24.3-3.51.9
Bone: periosteal perimeter4.38.412.53.5-3.21.7
Bone: post-yield work2.95.07.22.5-2.71.2
Progressive ratio test 1 active lever presses0.61.11.61.3-1.00.7
Progressive ratio test 1 breakpoint0.61.01.61.3-1.00.6
Progressive ratio test 1 inactive lever presses1.43.74.22.0-2.11.7
Progressive ratio test 2 active lever presses0.30.40.90.9-0.50.3
Progressive ratio test 2 breakpoint0.30.40.91.0-0.50.3
Progressive ratio test 2 inactive lever presses0.41.21.31.1-1.11.0
Incentive Sensitization - Responses0.00.10.20.10.4-0.4
Incentive Sensitization - Breakpoint0.10.10.20.10.4-0.4
Sum of active levers in priming session hrs 5-60.10.10.1-0.20.30.2
Progressive ratio0.00.10.20.0-0.40.1
Food seeking constrained by brief footshock0.10.10.20.4-0.40.3
Seeking ratio, punishment vs. effort0.00.00.10.30.2-0.1
Retroperitoneal fat weight2.19.612.22.5-3.23.5
Reaction time number correct0.51.82.2-1.11.4-1.5
Reaction time mean minus median0.00.20.30.6-0.30.4
Reaction time mean minus median AUC0.10.40.6-0.20.8-0.7
Reaction time num false alarms1.32.22.81.7-1.61.0
Reaction time num false alarms AUC1.02.22.91.7-1.61.0
Reaction time trials correct on left0.51.82.2-1.11.4-1.5
Reaction time trials on left0.51.72.0-1.01.4-1.4
Reaction time mean0.10.30.4-0.30.6-0.6
Reaction time mean AUC0.20.40.5-0.50.7-0.6
Median of all reaction times0.40.60.8-0.70.8-0.9
Reaction time omissions0.30.50.60.5-0.80.8
Reaction time false alarm rate2.73.74.62.0-2.11.6
Reaction time premature initiation rate2.53.94.32.0-2.11.9
Reaction time premature initiations0.30.91.21.1-1.00.8
Std. dev. reaction times0.00.00.00.10.0-0.1
Reaction time trials completed0.51.72.0-1.01.4-1.4
Reaction time trials AUC0.51.82.2-1.11.4-1.5
Run reversals in cocaine runway, females1.51.72.60.5-1.61.5
Run reversals in cocaine runway, males0.10.10.2-0.10.3-0.5
Latency to leave start box in cocaine runway2.53.53.7-1.91.9-1.8
Latency to leave start box in cocaine runway, F0.91.11.4-1.21.0-1.0
Latency to leave start box in cocaine runway, M2.82.63.4-1.61.8-1.4
Std. dev. time between licks in bursts0.20.30.7-0.80.2-0.4
Total sessions with >9 infusions0.10.10.30.50.10.0
Short access day 1 total inactive lever presses0.00.10.20.20.0-0.4
Short access day 10 total inactive lever presses0.21.41.90.9-1.31.4
Short access day 1 total infusions0.40.81.4-0.50.9-1.2
Short access day 10 total infusions1.11.82.81.7-1.31.0
Short access total infusions0.20.20.40.50.1-0.6
Short access day 1 locomotion0.61.01.60.8-0.71.3
Short access day 10 total locomotion1.77.17.52.7-2.72.5
Short access total locomotion3.14.76.02.0-2.02.4
One hour access (0.3 mA shock)1.61.93.21.8-1.40.7
Compulsive drug intake0.20.20.60.8-0.1-0.2
One hour access (shock baseline)0.30.71.30.8-1.10.5
Social response proportion0.40.50.80.7-0.90.0
Social responses1.41.92.91.5-1.70.6
Social time0.50.81.10.9-1.00.7
Soleus weight1.13.23.61.7-1.91.7
Bone: stiffness0.61.11.61.2-1.30.5
Tibialis anterior weight1.13.85.11.4-2.12.3
Time to tail flick, vehicle, before self-admin0.40.50.90.4-1.00.6
Time to tail flick, vehicle, after self-admin0.10.10.30.10.0-0.6
Time to tail flick, test, before self-admin0.40.50.80.9-0.8-0.1
Time to tail flick, test, after self-admin1.01.01.51.2-1.00.8
Delta time to tail flick, vehicle, before/after SA0.50.61.1-0.40.7-1.0
Delta time to tail flick, test, before/after SA0.10.20.30.6-0.20.4
Tibia length1.33.55.41.7-1.42.3
Ambulatory time before self-admin1.03.13.7-1.91.9-1.4
Ambulatory time after self-admin0.40.61.0-0.81.0-0.4
Bone: tissue strength2.02.12.6-1.51.6-1.2
Total heroin consumption0.00.10.1-0.10.00.4
Bone: trabecular number1.01.83.2-1.11.0-1.8
Bone: trabecular spacing0.40.61.00.4-0.71.0
Bone: trabecular thickness0.20.30.60.8-0.6-0.2
Bone: trabecular tissue density0.00.10.2-0.20.1-0.4
Water consumed over 24 hours0.40.81.8-1.30.7-0.3
Number of responses in last shaping day0.30.40.50.7-0.70.5