LOC120095197

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC120095197	0.11	0.05	1.3e-11	0.05	0.09	0.09	0.09	1.2e-06	3.2e-10	2.3e-10	2.0e-10
2	Brain	gene expression	LOC120095197	0.04	0.03	8.4e-03	0	0.01	0.01	0	2.4e-01	2.9e-02	7.5e-02	1.3e-01
3	LHb	mRNA stability	LOC120095197	0.48	0.18	3.5e-04	0.2	0.13	0.16	0.16	1.4e-05	4.9e-04	1.3e-04	1.0e-04
4	NAcc	gene expression	LOC120095197	0.07	0.04	2.6e-03	0.01	0.01	0.02	0.01	8.4e-03	5.4e-02	3.3e-03	2.1e-02
5	Brain	mRNA stability	LOC120095197	0.09	0.04	3.9e-06	0.06	0.06	0.07	0.08	2.0e-06	3.2e-06	5.4e-07	6.0e-08
6	NAcc	mRNA stability	LOC120095197	0.03	0.02	9.8e-03	0.02	0.01	0.01	0.01	1.9e-03	6.4e-02	1.8e-02	1.1e-02
7	PL	gene expression	LOC120095197	0.1	0.05	6.7e-04	0.01	0.02	0.01	0.01	7.4e-03	3.4e-03	8.7e-03	8.0e-03
8	Adipose	gene expression	LOC120095197	0.29	0.11	2.8e-16	0.14	0.14	0.14	0.14	3.6e-15	4.1e-15	1.2e-15	1.5e-15
9	BLA	gene expression	LOC120095197	0.19	0.09	1.3e-03	0.02	0.04	0.09	0.05	4.2e-02	2.2e-03	1.4e-05	9.2e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9
Bone: apparent density	0.4	0.6	1.2	1.1	0.7	-1.1	-0.2	0.7	-0.7	-0.5	-0.7	0.9
Area under the delay curve	1.0	1.0	3.5	0.3	-1.1	-0.9	1.0	0.1	-0.6	-1.3	-0.6	1.9
BMI with tail	3.8	12.2	27.4	-0.8	2.8	2.8	-5.2	-3.1	4.2	4.5	4.2	-1.5
BMI without tail	3.3	6.9	15.7	0.7	3.5	1.2	-4.0	-1.8	2.5	3.9	2.6	-0.6
Body weight	1.6	6.6	18.1	2.1	4.1	-0.1	-4.3	-0.5	1.8	3.3	1.9	-1.3
Weight adjusted by age	0.8	0.9	2.4	-0.9	-1.6	0.3	0.7	-0.9	1.2	-0.4	1.2	0.6
Bone surface	2.9	5.1	10.9	3.3	2.1	-3.1	0.1	2.7	-2.5	-0.9	-2.5	0.5
Bone volume	2.3	3.9	8.8	3.0	1.7	-2.8	0.0	2.3	-2.0	-0.9	-2.0	1.0
Breakpoint value in progressive ratio session	0.5	0.5	2.5	-0.4	-0.2	0.2	-0.3	-0.7	0.4	0.8	0.8	-1.6
Number of licking bursts	0.0	0.0	0.1	0.1	-0.1	-0.2	0.1	0.3	-0.3	-0.1	-0.2	-0.3
Context. condit. distance diff. score	0.0	0.0	0.3	-0.0	-0.1	-0.0	0.0	-0.2	0.3	-0.2	0.2	-0.5
Locomotion velocity, session 1	0.1	0.1	0.2	0.3	0.5	-0.4	-0.3	0.1	-0.3	0.4	-0.2	0.0
Locomotion distance, session 1	0.2	0.3	0.9	0.5	0.4	-0.7	-1.0	-0.2	0.2	0.8	0.5	-0.1
Locomotion velocity, session 2	0.8	0.9	4.5	0.5	0.8	-0.7	-0.5	0.2	-0.2	1.5	0.2	-2.1
Locomotion distance, session 2	0.5	0.7	2.9	-0.0	0.4	-0.3	-0.8	-0.7	0.5	1.7	1.0	-0.9
Locomotion velocity, session 3	1.2	1.4	3.8	-1.2	-0.9	0.5	-0.5	-1.9	1.2	1.4	1.6	-0.7
Locomotion distance, session 3	0.3	0.3	0.8	0.1	-0.8	-0.9	0.7	-0.2	-0.6	-0.3	-0.3	0.3
Stereotopy head waving bouts, day 3	0.5	0.6	1.9	-1.1	-1.4	0.7	0.5	-1.0	0.5	-0.4	0.4	0.7
Stereotopy head waving duration, day 3	0.6	0.7	2.5	-0.9	-1.6	0.2	0.7	-0.9	0.2	-0.5	0.3	1.0
Locomotion velocity, session 7	0.5	0.6	1.4	-0.7	0.2	0.9	-0.7	-0.5	0.9	0.7	0.7	-1.2
Locomotion distance, session 7	0.0	0.1	0.2	0.3	0.1	-0.2	0.1	0.4	-0.3	-0.2	-0.2	0.1
Stereotopy head waving bouts, day 7	1.1	1.3	2.7	-1.4	-1.2	0.8	-0.2	-1.6	1.3	0.8	1.4	-0.6
Stereotopy head waving duration, day 7	1.5	1.8	4.7	-2.1	-2.2	0.8	0.8	-1.8	0.9	0.4	1.1	-0.8
Locomotion velocity, session 8	0.2	0.2	0.8	0.5	0.6	-0.5	-0.0	0.5	-0.3	0.1	-0.4	-0.9
Locomotion distance, session 8	0.2	0.3	1.0	0.4	0.5	-0.5	-0.6	-0.2	0.3	0.8	0.4	-1.0
Degree of sensitization distance	0.2	0.2	0.6	0.5	0.7	0.2	-0.3	0.8	-0.1	-0.4	-0.4	0.1
Degree of sensitization stereotypy	2.0	2.2	3.6	-1.5	-0.8	0.8	-0.7	-1.9	1.6	1.7	1.9	-1.7
Conditioned locomotion	0.1	0.1	0.6	0.0	0.5	0.5	-0.1	-0.0	0.2	0.3	0.2	-0.8
Cocaine response after cond. corrected	0.6	0.6	1.8	-0.5	-1.3	0.1	1.0	0.2	-0.5	-1.3	-0.6	0.6
Cocaine response after cond. not corrected	0.7	0.8	2.6	-0.7	-1.6	-0.1	1.3	0.2	-0.6	-1.2	-0.7	-0.1
Cocaine response before conditioning	0.2	0.2	0.6	-0.1	-0.6	-0.8	0.5	-0.2	-0.4	0.3	-0.1	-0.5
Saline control response	2.2	2.9	6.0	0.0	1.9	0.9	-2.0	-1.2	1.9	2.4	1.9	-1.7
Bone: connectivity density	0.6	1.0	2.1	1.5	1.0	-1.4	0.0	1.1	-1.0	-0.4	-1.0	0.7
Bone: cortical apparent density	2.2	2.9	6.4	-1.9	-1.1	2.0	-0.8	-2.5	2.2	0.6	2.2	0.2
Bone: cortical area	1.8	2.6	7.6	1.8	2.5	-1.0	-2.8	-0.1	0.6	2.0	0.8	-0.9
Bone: cortical porosity	2.0	2.2	4.6	2.0	2.1	-1.6	-0.5	1.7	-1.0	1.1	-0.9	-1.6
Bone: cortical porosity	1.4	1.6	3.5	1.9	1.6	-1.8	-0.5	1.2	-0.8	1.1	-0.6	-0.7
Bone: cortical thickness	7.0	11.6	21.3	-2.3	0.2	2.5	-3.9	-4.4	4.4	3.7	4.6	-1.7
Bone: cortical thickness	4.2	4.8	8.2	-1.2	0.7	1.8	-2.3	-2.4	2.7	2.7	2.9	-2.2
Bone: cortical tissue density	2.1	2.7	5.9	-1.9	-1.1	2.0	-0.8	-2.4	2.1	0.6	2.1	0.1
Condit. Reinf. active minus inactive responses	2.2	2.5	6.3	2.3	0.8	-2.5	0.3	2.0	-1.9	-0.5	-1.6	0.4
Condit. Reinf. active-inactive response ratio	1.6	1.7	3.2	1.2	-0.1	-1.6	1.1	1.7	-1.8	-1.1	-1.6	0.6
Condit. Reinf. active responses	2.3	2.8	7.3	2.7	1.3	-2.7	-0.4	2.0	-1.6	-0.3	-1.4	0.0
Condit. Reinf. inactive responses	0.9	1.1	3.4	1.8	1.1	-1.6	-1.2	0.9	-0.4	0.1	-0.4	-0.2
Incentive salience index mean	1.2	1.5	4.0	2.0	1.1	-2.0	-0.4	1.4	-1.0	0.2	-0.8	-0.6
Condit. Reinf. lever presses	0.9	1.2	4.1	0.2	0.8	-0.2	-1.3	-0.4	0.9	1.5	1.0	-2.0
Condit. Reinf. active minus inactive responses	2.9	3.5	11.0	2.9	1.4	-3.3	-0.4	1.9	-2.1	0.1	-1.5	0.3
Condit. Reinf. active-inactive response ratio	1.6	1.6	4.1	1.6	0.7	-2.0	0.2	1.6	-1.6	-0.3	-1.4	0.1
Condit. Reinf. active responses	3.1	4.4	11.8	3.4	2.2	-3.2	-1.0	2.2	-1.9	0.4	-1.5	0.4
Condit. Reinf. inactive responses	1.6	2.0	5.7	2.4	2.1	-1.6	-1.6	1.0	-0.5	1.1	-0.2	0.2
Condit. Reinf. lever presses	1.7	2.3	6.0	2.0	2.5	-1.5	-1.7	0.6	-0.1	2.0	0.2	-0.7
Condit. Reinf. lever reinforcers received	2.7	3.8	10.1	3.2	2.1	-2.9	-1.0	2.1	-1.8	0.3	-1.4	0.5
Conditioned reinforcement - actives	0.1	0.1	0.7	0.3	0.5	-0.1	0.3	-0.1	-0.3	0.8	-0.0	-0.3
Conditioned reinforcement - inactives	0.9	1.0	3.1	1.8	1.4	-1.5	-1.0	0.9	0.1	0.4	0.2	-0.3
Conditioned locomotion	0.8	1.0	3.8	1.6	1.9	-0.7	-0.6	0.6	-0.6	0.6	-0.6	0.3
Patch foraging indifference point 0 sec	2.5	4.0	12.2	3.5	3.1	-2.3	-1.6	1.8	-1.4	0.6	-0.9	0.7
Patch foraging indifference point AUC	0.4	0.5	1.8	0.7	1.2	-0.4	-1.4	-0.1	0.2	0.5	-0.0	0.1
Delay disc. indifference point, 0s delay	0.6	0.6	2.0	-0.5	-1.4	-0.1	1.1	-0.3	0.1	-0.8	0.0	1.2
Delay disc. indifference point, 16s delay	0.4	0.4	2.7	0.1	-0.5	-0.3	0.3	-0.3	-0.1	-0.5	-0.0	1.6
Delay disc. indifference point, 2s delay	2.8	3.1	4.5	1.7	-0.6	-2.1	1.5	1.5	-1.8	-2.1	-1.8	2.1
Delay disc. indifference point, 24s delay	0.4	0.4	1.2	0.8	0.9	-0.6	-0.5	-0.1	-0.1	0.3	-0.0	1.1
Delay disc. indifference point, 4s delay	0.7	0.7	2.5	-0.6	-1.6	-0.4	1.1	-0.4	-0.5	-0.8	-0.4	1.0
Delay disc. indifference point, 8s delay	0.9	0.9	3.2	-0.4	-1.5	-0.3	0.8	-0.5	0.2	-1.2	0.2	1.8
Indifference point function ln k	0.1	0.1	0.3	0.0	-0.5	-0.2	-0.1	-0.3	0.1	0.1	0.6	-0.3
Indifference point function log k	0.1	0.1	0.3	0.0	-0.5	-0.2	-0.1	-0.3	0.1	0.1	0.6	-0.3
Patch foraging total patch changes 0 sec	2.3	3.7	10.9	3.3	2.9	-2.2	-1.4	1.7	-1.4	0.5	-1.0	0.9
Patch foraging total patch changes 12 sec	2.6	3.4	9.1	3.0	2.3	-2.1	-0.6	2.1	-1.8	-0.4	-1.7	0.6
Patch foraging total patch changes 18 sec	1.0	1.3	3.7	1.6	1.9	-0.9	-1.8	0.4	-0.0	1.0	0.2	-0.3
Patch foraging total patch changes 24 sec	2.0	2.4	6.3	2.5	2.4	-1.9	-2.0	0.9	-0.3	0.9	-0.1	0.6
Patch foraging total patch changes 6 sec	2.1	3.1	9.3	3.1	2.5	-2.2	-1.3	1.8	-1.1	0.3	-1.0	0.3
Patch foraging time to switch 0 sec	0.3	0.5	1.1	-1.1	-0.7	0.9	1.0	-0.4	-0.0	-0.3	0.2	-0.7
Patch foraging water rate 0 sec	0.9	1.5	4.8	1.9	2.2	-0.9	-1.3	1.0	-0.2	0.6	-0.4	0.6
Patch foraging water rate 12 sec	0.5	0.7	1.5	-0.2	0.2	0.3	-1.2	-0.8	1.1	1.2	1.1	-0.0
Patch foraging water rate 18 sec	0.2	0.3	0.5	0.7	0.5	-0.6	-0.6	-0.0	0.4	0.6	0.7	-0.2
Patch foraging water rate 24 sec	0.2	0.3	0.7	0.3	-0.9	-0.7	0.7	0.3	-0.4	-0.6	-0.1	0.2
Patch foraging water rate 6 sec	0.4	0.6	1.7	0.0	0.0	0.2	-1.1	-0.6	1.3	0.6	1.3	-0.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.5	0.1	0.4	0.2	-0.7	-0.6	0.7	0.5	0.6	-0.4
Distance traveled before self-admin	1.0	1.1	3.9	-0.7	-2.0	-0.6	1.7	0.1	-0.9	-1.0	-0.7	0.3
Distance traveled after self-admin	0.4	0.4	1.1	-0.6	-1.1	-0.6	1.0	-0.0	-0.5	0.0	-0.3	-0.7
Extensor digitorum longus weight	1.5	5.7	16.8	-2.9	-0.2	4.1	-2.1	-2.3	3.2	0.9	2.3	-0.2
Bone: elastic displacement	0.6	0.7	1.5	-0.9	-0.8	0.5	-0.5	-1.2	0.7	0.9	0.9	-0.7
Bone: elastic work	1.1	1.4	3.8	0.4	1.4	0.4	-1.9	-0.7	1.2	1.6	1.1	-1.0
Bone: endosteal estimation	9.5	20.7	41.7	6.5	4.3	-5.2	0.9	6.4	-5.2	-1.7	-5.2	0.4
Bone: endosteal perimeter	9.4	19.4	37.7	6.1	3.7	-5.4	0.9	5.9	-5.1	-2.1	-5.2	1.1
Epididymis fat weight	1.1	2.5	5.0	0.1	2.1	1.8	-2.2	-0.7	2.1	1.2	1.8	-0.8
Delta time in closed arm before/after self-admin	0.5	0.5	0.9	0.3	-0.5	-0.7	0.9	0.9	-0.4	-1.0	-0.9	0.1
Delta time in open arm before/after self-admin	0.5	0.5	1.2	-0.8	-1.0	0.6	-0.1	-0.8	0.4	-0.2	0.7	1.1
Diff in mean of infusions in LGA sessions	1.9	2.1	3.7	-1.6	-0.2	1.9	-0.5	-1.9	1.4	1.6	1.7	-1.1
Delay discount exponential model param	1.2	1.2	3.4	-0.5	0.9	1.1	-1.1	-0.4	1.0	1.5	1.0	-1.8
Extinction: sum of active levers before priming	0.1	0.1	0.9	0.1	0.3	0.2	-0.9	-0.2	0.2	0.3	0.3	-0.0
Active lever presses in extinction session 6	0.7	0.6	2.3	1.0	1.5	-0.2	-0.9	0.5	-0.3	0.8	-0.4	-0.7
Bone: final force	1.1	1.7	5.3	2.3	1.8	-1.8	-1.0	1.2	-0.7	0.3	-0.6	-0.4
Bone: final moment	1.1	1.8	5.5	2.4	1.9	-1.9	-1.0	1.2	-0.8	0.3	-0.6	-0.5
Food consumed during 24 hour testing period	2.2	2.7	7.1	0.7	2.5	0.7	-2.7	-0.4	1.6	2.1	1.3	-0.8
Glucose	0.5	0.8	2.0	-1.4	-1.2	1.0	1.0	-1.1	0.3	0.3	0.5	-0.4
Heart weight	0.2	0.2	1.2	0.1	-0.5	-0.5	0.2	-0.3	-0.2	-0.1	0.0	1.1
Delay discount hyperbolic model param	1.2	1.3	3.7	-0.6	1.0	1.2	-1.2	-0.4	0.9	1.5	0.9	-1.9
Intermittent access intake day 1-15 change	0.4	0.4	1.8	0.2	0.5	0.3	0.1	1.3	-0.6	-0.6	-1.0	0.1
Intermittent access intake escalation	0.4	0.4	1.3	0.0	0.2	0.3	0.3	1.1	-0.5	-0.7	-1.0	0.1
Intermittent access intake escalation 2	1.3	1.2	3.6	0.8	1.0	0.2	0.2	1.9	-1.2	-0.9	-1.8	0.4
Intermitt. access day 1 inactive lever presses	1.9	2.0	4.3	2.1	1.6	-2.0	-1.5	0.7	-0.3	1.2	0.3	-1.5
Intermitt. access day 15 inactive lever presses	0.9	1.0	2.1	1.0	1.4	-0.2	-1.5	0.3	0.7	0.8	0.7	-1.4
Intermitt. access escalation Index	0.9	0.8	3.1	-1.8	-1.5	0.7	1.1	-0.6	-0.2	-0.1	-0.3	0.3
Intermittent access day 1 total infusions	0.5	0.6	1.3	1.2	0.8	-1.0	-1.0	-0.4	0.4	1.1	0.6	0.1
Intermittent access day 15 total infusions	0.3	0.3	1.0	0.9	1.0	-0.3	-0.4	0.6	-0.2	0.4	-0.4	0.3
Intermittent access terminal intake (last 3 days)	1.1	1.2	3.1	1.8	1.7	-0.9	-0.4	1.4	-0.7	0.0	-1.0	0.4
Intermittent access total infusions	1.2	1.4	4.8	2.2	1.7	-1.6	-0.9	0.9	-0.4	0.6	-0.3	0.1
Intermittent access day 1 locomotion	1.4	1.4	4.4	2.1	1.9	-1.5	-1.2	0.3	0.1	1.0	0.4	-0.1
Intermittent access day 15 total locomotion	2.4	2.5	7.9	2.8	2.5	-1.6	-1.4	1.6	-0.9	0.3	-0.5	-0.4
Intermittent access total locomotion	3.7	4.2	12.8	3.6	3.6	-2.0	-2.2	1.3	-0.2	1.3	-0.0	-0.4
Intermittent access standard deviation	0.5	0.5	1.8	1.1	1.4	-0.4	-0.6	0.6	-0.2	0.4	-0.5	-0.2
Left kidney weight	0.9	2.4	5.9	-0.2	0.1	-0.1	-1.7	-2.0	1.9	2.4	2.1	-1.1
Right kidney weight	0.6	1.7	5.6	0.1	0.8	0.0	-1.8	-1.4	1.2	2.4	1.4	-0.9
Cocaine induced anxiety	0.1	0.1	0.2	0.1	-0.4	-0.4	0.2	0.0	-0.4	-0.1	0.1	0.3
Post-drug Anxiety	0.6	0.7	1.9	-0.8	-1.4	0.3	1.3	-0.4	-0.3	-0.9	0.1	0.9
Baseline Anxiety	1.0	1.1	2.7	-1.6	-1.0	1.6	0.5	-1.3	0.9	0.0	0.9	0.2
Tail length	0.6	1.7	4.3	2.1	2.0	-1.3	-0.2	1.4	-1.2	0.2	-1.2	0.3
Length with tail	0.9	3.3	7.7	2.8	1.4	-2.6	0.2	2.2	-1.9	-1.0	-1.9	0.5
Length without tail	0.3	0.7	1.7	0.9	-0.1	-1.0	0.4	1.2	-0.6	-1.3	-0.8	-0.1
Times rat made contact with spout	0.4	0.4	1.5	0.5	1.2	0.0	-1.2	0.4	-0.0	0.7	-0.2	-0.5
Lifetime Intake	1.6	1.8	5.4	2.3	2.0	-1.7	-1.5	0.4	0.1	1.2	0.3	-0.4
Liver weight, left	0.3	0.6	1.2	0.8	0.2	-0.8	0.2	0.8	-1.0	-0.6	-1.1	-0.5
Liver weight, right	0.1	0.2	0.7	-0.1	-0.3	0.0	-0.8	-0.6	0.5	0.1	0.5	0.4
Locomotor activity	1.9	3.0	10.1	1.3	2.2	-1.0	-2.1	-0.8	0.6	3.2	1.2	-1.6
Locomotor testing distance	1.9	3.2	10.5	1.1	2.1	-0.8	-2.4	-0.9	0.8	3.2	1.3	-1.9
Locomotor testing rearing	2.3	3.6	9.1	0.4	2.2	0.2	-2.7	-0.4	1.2	2.8	1.2	-3.0
Locomotion in novel chamber	0.9	1.1	2.4	0.5	-1.4	-1.5	1.5	0.8	-0.6	-1.6	-0.3	0.2
Locomotion in novel chamber post-restriction	2.8	3.4	6.0	2.5	0.4	-2.4	1.0	2.4	-1.9	-2.1	-1.8	0.7
Fecal boli incidents, locomotor time 1	0.8	0.9	2.1	-0.4	-1.2	-0.4	1.4	0.4	-0.7	-1.5	-0.7	0.8
Change in fecal boli incidents, locomotor task	0.2	0.2	0.9	0.1	0.2	0.3	-0.2	0.1	-0.8	-0.1	-0.5	1.0
Time >=10cm from walls, locomotor time 1	0.5	0.5	2.2	-0.8	-1.5	-0.2	1.3	-0.3	-0.3	-0.4	0.3	-0.2
Bouts of movement, locomotor time 1	0.8	0.9	2.6	-0.2	0.4	1.2	-1.2	-0.4	1.6	0.5	1.3	-0.5
Total resting periods, locomotor time 1	0.5	0.5	1.6	-0.2	0.2	1.1	-1.0	-0.2	1.2	0.1	0.9	-0.3
Rest time, locomotor task time 1	0.3	0.3	0.8	-0.7	-0.9	0.5	0.3	0.1	0.5	-0.8	0.1	-0.3
Distance moved, locomotor task time 1	0.3	0.3	1.0	0.2	1.0	0.2	-0.6	-0.5	0.3	0.8	0.5	-0.1
Vertical activity count, locomotor time 1	0.1	0.1	0.4	0.3	0.6	-0.1	-0.4	0.0	0.3	0.3	0.4	0.2
Time >=10cm from walls, locomotor time 2	1.6	1.7	3.3	-1.1	0.2	1.3	-1.0	-0.7	1.8	1.2	1.8	-1.8
Bouts of movement, locomotor time 2	2.3	2.5	6.2	-1.0	0.4	1.9	-1.5	-1.5	2.5	1.3	2.2	-0.5
Total resting periods, locomotor time 2	1.8	2.0	5.5	-1.0	-0.1	1.6	-1.2	-1.4	2.3	1.0	2.1	-0.4
Rest time, locomotor task time 2	2.8	3.2	11.7	-2.3	-3.4	1.2	2.1	-1.0	0.3	-1.8	0.2	1.0
Distance moved, locomotor task time 2	2.8	3.2	6.1	-0.2	2.2	1.3	-2.5	-0.9	1.6	2.5	1.7	-2.1
Vertical activity count, locomotor time 2	3.2	3.5	10.3	0.8	3.2	0.2	-2.9	-0.1	1.0	2.6	1.2	-1.8
Light reinforcement 1	1.6	2.8	6.2	-0.2	0.9	0.8	-2.5	-1.8	2.2	1.9	2.4	-0.1
Light reinforcement 2	0.3	0.4	1.2	0.2	-0.3	-0.3	-0.6	-0.8	0.7	-0.3	0.8	1.1
Bone: marrow area	9.3	20.1	40.2	6.3	4.2	-5.1	0.9	6.3	-5.1	-1.7	-5.2	0.3
Bone: maximum diameter	3.6	6.7	14.9	3.9	2.0	-3.8	0.1	3.0	-2.9	-0.9	-2.7	0.9
Bone: maximum force	1.5	2.6	8.0	2.8	2.4	-2.1	-1.5	1.3	-0.9	0.6	-0.6	0.1
Bone: maximum moment	1.6	2.8	8.3	2.9	2.5	-2.1	-1.6	1.3	-0.9	0.6	-0.7	0.0
Mean time between licks in bursts	0.0	0.1	0.2	0.1	0.4	0.2	-0.3	0.1	0.1	-0.0	0.0	0.4
Mean num. licks in bursts	0.1	0.2	0.4	0.1	0.6	0.4	-0.7	-0.2	0.3	0.4	0.1	0.4
Cd content in liver	1.7	1.8	6.0	-1.1	-1.8	0.8	2.5	0.4	-0.7	-1.9	-0.9	0.5
Co content in liver	0.6	0.7	2.5	-0.4	-1.1	-0.0	1.6	0.4	-0.5	-1.2	-0.7	-0.5
Cu content in liver	0.1	0.2	0.3	0.4	0.0	-0.1	0.1	0.5	-0.5	-0.5	-0.6	0.4
Fe content in liver	0.1	0.2	0.4	0.5	0.1	-0.7	-0.5	0.1	-0.1	0.4	0.1	-0.4
K content in liver	1.3	1.3	2.5	1.0	-0.5	-1.5	1.3	1.1	-1.2	-1.6	-1.1	0.0
Mg content in liver	1.0	1.1	3.0	0.6	-0.5	-0.7	1.3	1.2	-1.0	-1.7	-1.2	0.4
Mn content in liver	1.2	1.4	3.3	1.2	-0.3	-1.8	1.4	0.8	-1.4	-0.9	-1.1	1.2
Na content in liver	0.6	0.6	1.8	0.3	-1.0	-1.3	1.4	-0.3	-0.6	-0.6	-0.2	-0.4
Rb content in liver	0.9	1.1	3.5	-0.3	-1.4	-0.7	1.9	0.4	-1.2	-1.1	-0.9	0.8
Se content in liver	1.2	1.4	6.3	-1.2	-2.5	-0.2	1.3	-1.0	-0.2	-1.0	0.1	1.0
Sr content in liver	0.1	0.1	0.3	0.2	0.5	0.0	-0.0	-0.3	0.2	0.6	0.3	-0.4
Zn content in liver	1.1	1.2	3.2	-0.0	-1.8	-1.2	1.1	-0.0	-1.0	-1.4	-0.8	1.1
Bone: minimum diameter	5.6	10.5	26.1	5.1	4.1	-3.8	-0.7	4.0	-3.1	-0.5	-3.1	0.7
Time in familiar zone, hab. session 1	0.9	0.8	2.0	1.0	0.8	-0.5	0.3	1.4	-1.0	-1.0	-1.2	0.4
Time in novel zone, hab. session 1	1.5	1.5	2.3	-1.3	-0.2	1.1	-1.0	-1.5	1.4	1.5	1.5	-0.6
Total zone transitions, hab. session 1	1.4	2.0	4.8	0.7	1.7	0.0	-1.7	-0.5	1.2	2.2	1.4	-1.7
Total locomotion distance, hab. session 1	1.9	2.7	6.5	1.3	2.2	-0.4	-2.5	-0.3	1.1	2.5	1.4	-1.3
Locomotion velocity, hab. session 1	1.4	2.0	4.6	1.5	1.9	-0.7	-2.1	0.0	0.8	1.9	1.0	-1.1
Time in familiar zone, hab. session 2	0.6	0.6	1.1	1.0	0.9	-0.8	-0.3	1.1	-0.8	-0.3	-0.9	-0.7
Time in novel zone, hab. session 2	0.4	0.4	1.1	-0.7	-0.9	0.6	0.4	-0.5	0.3	-0.1	0.4	1.1
Total zone transitions, hab. session 2	2.2	2.8	6.0	-0.4	1.3	1.0	-2.0	-1.2	1.8	2.4	1.9	-2.1
Total locomotion distance, hab. session 2	1.9	2.5	7.6	0.6	1.9	0.6	-2.8	-0.7	1.6	2.0	1.6	-1.1
Locomotion velocity, hab. session 2	1.7	2.2	6.9	0.4	1.6	0.6	-2.6	-0.8	1.6	1.9	1.6	-0.9
Novel to familiar place preference ratio	1.2	1.2	3.6	1.9	1.1	-1.3	-0.1	1.4	-1.0	-0.3	-1.0	0.6
Novelty place preference	0.8	0.8	2.4	1.5	1.0	-1.0	-0.1	1.1	-0.8	-0.0	-0.8	0.3
Time in novel zone, NPP test	0.7	0.7	2.2	1.5	0.9	-1.0	-0.1	1.1	-0.8	0.1	-0.7	0.1
Total zone transitions, NPP test	1.5	2.1	5.1	-0.1	0.8	0.1	-2.1	-1.6	1.6	2.3	1.9	-0.6
Total locomotion distance, NPP test	1.3	1.8	6.4	0.8	1.7	-0.1	-2.5	-0.4	1.1	1.7	1.2	-0.5
Locomotion velocity, NPP test	1.3	1.8	6.6	0.5	1.3	0.1	-2.6	-0.9	1.4	1.7	1.5	0.1
Intraocular pressure	0.4	0.6	1.5	-0.2	0.1	0.1	-1.2	-1.0	0.5	1.2	1.0	0.3
Delta distance traveled before/after self-admin	1.7	1.9	4.4	-0.8	0.8	0.9	-1.5	-1.3	1.6	2.1	1.6	-1.2
Delta ambulatory time before/after self-admin	0.5	0.5	1.8	-0.2	1.0	0.4	-0.9	-0.4	0.5	1.3	0.4	-0.2
Parametrial fat weight	1.1	2.1	3.8	1.3	0.6	-0.5	0.8	1.9	-1.5	-1.7	-1.9	2.0
Pavlov. Cond. lever latency	1.8	2.2	4.9	-0.7	-1.6	0.7	2.1	0.7	-1.2	-2.2	-1.3	1.9
Pavlov. Cond. magazine entry latency	0.9	1.2	3.5	1.9	1.2	-1.8	-0.5	0.8	-0.6	0.6	-0.3	-0.7
Pavlov. Cond. change in total contacts	1.3	1.4	2.8	1.2	1.6	-1.1	-1.7	-0.1	0.3	1.7	0.4	-1.3
Pavlov. Cond. index score	1.1	1.3	2.3	1.5	1.4	-1.5	-1.4	0.1	0.3	1.3	0.4	-1.2
Pavlov. Cond. latency score	1.2	1.5	2.8	1.1	1.4	-1.2	-1.6	-0.3	0.7	1.7	0.8	-1.5
Pavlov. Cond. lever contacts	2.4	2.8	5.8	0.2	1.5	0.0	-2.3	-0.9	1.7	2.3	1.6	-2.4
Pavlov. Cond. magazine entry number	0.9	1.1	4.3	-1.8	-0.6	2.1	-0.1	-0.9	0.9	-0.0	0.7	-0.1
Pavlov. Cond. intertrial magazine entries	1.1	1.4	4.1	2.0	1.1	-1.8	-0.4	1.2	-0.9	-0.1	-0.6	1.0
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	2.1	1.4	1.3	-1.5	-1.4	0.0	0.3	1.4	0.5	-1.2
Pavlov. Cond. response bias	0.9	1.0	2.8	1.5	1.1	-1.7	-0.9	0.3	-0.1	1.0	0.1	-0.9
Pavlov. Cond. lever latency	0.3	0.4	1.7	-0.9	-0.5	1.3	0.2	-0.3	0.5	-0.5	0.2	-0.3
Pavlov. Cond. magazine entry latency	1.0	1.2	3.8	-1.7	-1.9	0.3	1.4	-1.1	0.4	-0.4	0.5	-0.3
Pavlov. Cond. change in total contacts	0.3	0.4	1.7	0.6	-0.1	-1.3	0.3	0.5	-0.7	-0.2	-0.6	0.3
Pavlov. Cond. index score	0.1	0.1	0.7	-0.0	-0.2	-0.8	0.3	-0.1	-0.2	0.4	0.1	-0.1
Pavlov. Cond. latency score	0.1	0.2	0.8	-0.1	-0.5	-0.9	0.6	-0.2	-0.2	0.3	0.0	-0.1
Pavlov. Cond. lever contacts	0.3	0.4	1.0	0.7	0.9	-0.8	-0.7	-0.0	0.1	1.0	0.3	0.1
Pavlov. Cond. magazine entry number	1.1	1.4	4.5	1.9	2.1	-0.4	-1.2	1.4	-0.6	0.1	-0.8	0.4
Pavlov. Cond. intertrial magazine entries	3.2	4.2	14.0	3.2	3.7	-0.9	-2.0	2.3	-1.0	0.2	-1.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.8	-0.0	-0.4	-0.9	0.5	-0.1	-0.2	0.2	-0.0	-0.0
Pavlov. Cond. response bias	0.1	0.1	0.7	0.4	0.3	-0.8	-0.2	0.0	-0.1	0.4	0.1	0.2
Time in closed arm before self-admin	0.8	0.8	3.2	-0.6	0.5	0.5	-0.8	-1.3	0.3	1.8	0.9	-0.7
Time in closed arm after self-admin	0.1	0.1	0.4	-0.3	0.0	-0.1	0.4	0.1	-0.2	0.3	-0.5	-0.6
Time in open arm before self-admin	0.4	0.4	1.2	-1.1	-0.9	0.7	0.5	-0.2	0.7	-0.3	0.4	-0.6
Time in open arm after self-admin	0.4	0.4	1.3	-0.4	-1.1	0.0	0.2	0.1	0.5	-1.2	0.4	0.8
Bone: periosteal estimation	5.5	11.3	29.0	5.4	4.3	-4.2	-1.0	4.1	-3.2	-0.0	-3.1	-0.0
Bone: periosteal perimeter	3.0	4.9	11.4	3.4	2.0	-3.3	-0.2	2.6	-2.4	-0.5	-2.3	0.4
Bone: post-yield work	1.1	1.6	3.8	2.0	1.6	-1.6	0.0	1.5	-1.1	-0.3	-1.2	0.1
Progressive ratio test 1 active lever presses	1.9	2.0	5.4	1.9	2.3	-1.5	-1.5	0.0	0.3	2.0	0.4	-0.6
Progressive ratio test 1 breakpoint	2.4	2.5	6.7	1.9	2.6	-1.4	-1.8	-0.2	0.5	2.3	0.7	-0.6
Progressive ratio test 1 inactive lever presses	2.7	3.0	6.2	2.5	2.3	-2.4	-2.0	0.2	0.4	2.0	0.7	-0.9
Progressive ratio test 2 active lever presses	1.8	1.9	5.8	2.4	1.0	-2.4	0.2	1.4	-1.1	-0.4	-1.0	0.6
Progressive ratio test 2 breakpoint	1.9	2.1	6.1	2.5	1.3	-2.3	0.1	1.6	-1.2	-0.4	-1.1	0.6
Progressive ratio test 2 inactive lever presses	2.4	2.8	9.5	3.1	1.5	-2.7	-0.5	1.6	-1.3	-0.4	-0.7	0.6
Incentive Sensitization - Responses	1.8	1.8	3.0	1.6	-0.1	-1.7	1.0	1.6	-1.4	-1.6	-1.4	0.7
Incentive Sensitization - Breakpoint	2.0	2.0	3.1	1.6	-0.2	-1.8	1.1	1.7	-1.6	-1.7	-1.5	0.7
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.6	-0.7	-0.2	0.4	0.7	-0.5	-0.2	0.8	-0.2	-0.2
Progressive ratio	1.9	2.1	5.5	-0.2	-1.6	-0.8	2.1	0.7	-1.4	-2.4	-1.4	1.2
Food seeking constrained by brief footshock	1.3	1.6	3.7	1.1	1.9	-0.5	0.0	1.5	-1.7	0.3	-1.6	-1.2
Seeking ratio, punishment vs. effort	1.7	2.1	6.2	1.0	2.5	0.3	-1.7	0.4	0.4	2.2	0.4	-1.8
Retroperitoneal fat weight	1.5	4.9	14.1	1.8	3.8	0.7	-3.6	0.6	1.8	1.9	1.5	-2.0
Reaction time number correct	0.5	0.7	2.7	-0.3	-1.7	-0.5	0.7	-0.1	-0.4	-0.9	0.2	1.4
Reaction time mean minus median	0.2	0.2	1.1	-0.7	-0.1	1.0	0.5	0.1	0.1	-0.3	-0.2	0.1
Reaction time mean minus median AUC	0.3	0.4	1.2	-0.3	-0.6	0.1	1.1	0.3	-0.8	-0.5	-0.7	1.0
Reaction time num false alarms	1.2	1.6	5.0	2.0	1.2	-2.2	-0.8	0.8	-1.3	0.6	-0.7	-0.5
Reaction time num false alarms AUC	1.4	1.9	4.8	2.2	1.5	-2.2	-0.6	1.0	-1.6	0.4	-1.1	-0.2
Reaction time trials correct on left	0.5	0.7	2.7	-0.3	-1.7	-0.5	0.7	-0.1	-0.4	-0.9	0.2	1.4
Reaction time trials on left	0.5	0.8	2.7	-0.2	-1.6	-0.5	0.7	0.0	-0.5	-1.0	0.1	1.5
Reaction time mean	0.8	1.2	4.0	-0.2	-1.0	-0.2	2.0	0.7	-1.4	-1.3	-1.1	0.3
Reaction time mean AUC	0.6	0.7	3.0	-0.5	-0.9	0.2	1.7	0.5	-1.0	-0.8	-0.8	-0.0
Median of all reaction times	1.0	1.3	4.4	0.1	-1.0	-0.6	2.1	0.8	-1.6	-1.2	-1.2	0.3
Reaction time omissions	0.5	0.6	1.1	0.7	0.1	-0.2	0.2	0.9	-1.0	-1.0	-1.0	1.1
Reaction time false alarm rate	1.2	1.7	4.0	1.8	2.0	-1.4	-0.9	0.8	-1.0	1.0	-0.9	-1.3
Reaction time premature initiation rate	0.6	0.8	2.4	1.1	1.3	-0.4	-1.6	-0.1	0.5	0.8	0.3	-0.7
Reaction time premature initiations	0.2	0.3	1.2	0.7	0.4	-0.5	-1.1	-0.1	0.3	0.3	0.4	0.2
Std. dev. reaction times	0.7	1.0	2.1	-0.2	-0.4	0.3	1.3	1.1	-1.3	-1.3	-1.5	0.4
Reaction time trials completed	0.5	0.8	2.7	-0.2	-1.6	-0.5	0.7	0.0	-0.5	-1.0	0.1	1.5
Reaction time trials AUC	0.5	0.7	2.4	-0.2	-1.5	-0.5	0.7	0.1	-0.5	-1.0	0.1	1.4
Run reversals in cocaine runway, females	3.4	3.3	8.9	-1.5	0.5	2.6	-1.3	-1.5	3.0	1.0	2.3	-1.3
Run reversals in cocaine runway, males	0.6	0.6	1.4	0.4	-0.9	-0.8	0.8	0.3	-0.5	-1.2	-0.5	0.9
Latency to leave start box in cocaine runway	1.5	1.6	3.1	-0.8	-0.1	0.8	-1.6	-1.0	1.8	1.4	1.5	-1.5
Latency to leave start box in cocaine runway, F	1.4	1.6	3.0	-0.8	-0.8	0.0	-1.3	-1.4	1.6	1.3	1.7	-1.3
Latency to leave start box in cocaine runway, M	0.8	0.7	1.8	-0.4	0.9	1.4	-0.8	0.2	1.2	0.4	0.6	-1.1
Std. dev. time between licks in bursts	0.5	0.6	1.2	-0.7	0.2	1.1	-0.7	-0.9	1.1	0.5	1.0	-0.3
Total sessions with >9 infusions	1.1	1.2	3.9	0.4	0.5	-0.6	-0.8	-1.6	1.1	2.0	1.3	-0.0
Short access day 1 total inactive lever presses	0.9	1.0	2.5	1.4	0.7	-1.6	-1.1	0.1	1.0	0.7	1.0	-0.6
Short access day 10 total inactive lever presses	0.9	1.0	3.1	1.4	1.3	-0.8	-1.8	0.9	-0.1	0.2	0.3	-0.9
Short access day 1 total infusions	1.8	1.9	4.0	1.5	0.8	-1.5	-1.7	-1.0	1.0	2.0	1.6	-0.6
Short access day 10 total infusions	3.5	3.9	11.0	2.7	3.3	-1.4	-3.0	0.3	1.0	1.9	0.9	-0.7
Short access total infusions	2.8	3.1	5.6	2.3	2.3	-1.8	-2.4	-0.2	0.9	2.3	1.1	-1.2
Short access day 1 locomotion	2.3	2.5	5.3	2.1	2.3	-1.3	-2.1	-0.6	0.9	1.9	1.3	0.1
Short access day 10 total locomotion	3.4	3.8	12.8	3.2	3.6	-1.6	-2.1	1.2	-0.5	1.3	-0.3	-0.6
Short access total locomotion	3.5	3.7	9.6	2.2	3.1	-1.0	-2.8	-0.6	1.0	2.6	1.3	-0.6
One hour access (0.3 mA shock)	0.6	0.7	1.4	1.1	1.2	-0.9	0.1	0.7	-1.0	0.6	-0.8	-0.2
Compulsive drug intake	0.5	0.5	1.1	-0.6	-0.9	-0.1	1.0	0.2	-1.1	-0.4	-0.7	0.5
One hour access (shock baseline)	0.4	0.4	1.8	1.1	1.3	-0.6	-0.4	0.3	0.1	0.6	0.0	-0.2
Social response proportion	0.1	0.1	0.5	-0.2	-0.2	-0.2	0.1	0.2	-0.7	-0.2	-0.5	0.2
Social responses	0.5	0.7	2.2	0.6	1.5	-0.5	-0.6	0.1	-0.4	1.5	-0.0	-0.7
Social time	0.5	0.6	1.2	-0.6	-1.0	0.0	1.1	0.4	-0.9	-1.1	-0.8	0.5
Soleus weight	0.1	0.4	1.0	0.2	-0.1	-0.6	-0.9	-0.9	0.4	1.0	0.7	-0.5
Bone: stiffness	0.9	1.4	4.3	2.1	1.6	-1.8	-0.5	1.1	-0.7	0.1	-0.5	0.1
Tibialis anterior weight	1.1	3.8	10.4	-0.4	2.1	2.0	-3.2	-1.1	2.3	2.1	1.8	-0.9
Time to tail flick, vehicle, before self-admin	4.2	4.3	8.8	0.1	-1.8	-1.2	3.0	1.7	-2.5	-2.8	-2.3	1.6
Time to tail flick, vehicle, after self-admin	3.3	3.6	8.1	0.8	-0.8	-1.4	1.9	1.4	-2.2	-2.3	-2.2	2.8
Time to tail flick, test, before self-admin	1.9	1.9	5.1	-0.5	-0.4	0.4	2.3	1.1	-1.7	-1.4	-2.1	0.9
Time to tail flick, test, after self-admin	0.6	0.6	1.6	0.4	0.1	-0.6	0.4	0.6	-1.2	-0.2	-1.2	1.3
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.9	1.2	1.4	-0.4	-0.2	0.8	-1.0	-0.2	-1.3	1.1
Delta time to tail flick, test, before/after SA	0.6	0.6	1.7	1.0	-0.4	-1.3	0.1	0.6	-0.7	-0.6	-0.5	0.8
Tibia length	0.2	0.7	3.8	0.3	-0.6	-1.1	0.3	-0.4	-0.4	0.3	0.0	2.0
Ambulatory time before self-admin	0.6	0.6	2.8	-0.6	-1.7	-0.5	1.2	-0.2	-0.4	-0.8	-0.1	-0.1
Ambulatory time after self-admin	0.1	0.2	0.5	-0.2	-0.4	-0.7	0.2	-0.1	-0.0	0.5	0.1	-0.6
Bone: tissue strength	0.4	0.4	2.0	-0.7	-1.4	-0.3	0.5	-0.8	0.1	-0.1	0.5	0.3
Total heroin consumption	0.4	0.5	2.1	0.5	-0.1	-1.0	0.5	0.2	-1.5	0.1	-0.8	-0.1
Bone: trabecular number	0.9	1.4	3.6	1.6	0.4	-1.9	0.3	1.1	-1.2	-0.9	-1.1	1.2
Bone: trabecular spacing	0.3	0.4	1.0	-1.0	-0.3	1.0	-0.2	-0.5	0.6	0.5	0.5	-0.9
Bone: trabecular thickness	0.7	0.8	1.9	1.4	1.1	-0.9	-0.5	0.7	-0.5	-0.4	-0.6	1.3
Bone: trabecular tissue density	0.4	0.6	2.1	-0.7	-0.9	0.4	-0.2	-1.0	0.6	-0.2	0.7	1.5
Water consumed over 24 hours	1.1	1.3	3.0	0.0	1.4	0.8	-1.7	-0.8	1.1	1.7	1.0	-0.6
Number of responses in last shaping day	0.8	0.8	1.7	1.0	0.7	-1.0	-1.3	-0.2	0.3	0.9	1.3	-0.6