Hub : Genes

LOC120094677

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr9_52093689_52094394 0.34 0.12 2.0e-13 0.24 0.29 0.26 0.27 2.1e-10 1.6e-12 3.5e-11 7.6e-12
2 NAcc alternative polyA XR_005489124.2 0.05 0.03 1.2e-06 0.04 0.03 0.03 0.03 1.1e-06 6.2e-05 9.8e-06 1.5e-05
3 NAcc alternative polyA XR_010054779.1 0.05 0.03 1.9e-06 0.04 0.03 0.03 0.03 1.4e-06 7.4e-05 1.7e-05 2.0e-05
4 PL alternative polyA XR_005489124.2 0.04 0.03 8.2e-05 0.03 0.03 0.02 0.02 2.7e-04 4.9e-04 1.4e-03 3.3e-03
5 PL alternative polyA XR_010054779.1 0.04 0.03 8.5e-05 0.03 0.03 0.02 0.02 2.0e-04 5.5e-04 2.4e-03 3.9e-03
6 NAcc gene expression LOC120094677 0.05 0.03 1.9e-07 0.03 0.05 0.04 0.05 5.9e-06 1.5e-07 9.4e-07 1.4e-07
7 PL isoform ratio XR_010054779.1 0.04 0.02 1.1e-03 0 0.02 0 0.01 1.5e-01 5.6e-03 3.2e-01 4.7e-02
8 PL intron excision ratio chr9_52093689_52094394 0.08 0.04 1.6e-09 0.09 0.08 0.07 0.08 2.4e-10 8.7e-09 1.3e-08 4.2e-09
9 pVTA alternative polyA XR_005489124.2 0.05 0.03 9.1e-04 0.01 0.02 0.01 0.01 9.1e-02 6.0e-03 6.6e-02 3.9e-02
10 pVTA alternative polyA XR_010054779.1 0.05 0.03 1.4e-03 0 0.02 0 0.01 2.3e-01 1.2e-02 1.4e-01 8.0e-02
11 IC alternative polyA XR_010054779.1 0.12 0.08 1.9e-03 0.04 0.05 0.02 0.04 6.8e-03 4.9e-03 3.9e-02 6.2e-03
12 IC alternative polyA XR_005489124.2 0.12 0.08 2.0e-03 0.04 0.05 0.02 0.04 7.2e-03 5.1e-03 4.2e-02 5.9e-03
13 PL gene expression LOC120094677 0.05 0.03 9.0e-05 0.01 0.04 0.03 0.02 1.5e-02 8.5e-05 6.2e-04 1.2e-03
14 IC gene expression LOC120094677 0.23 0.14 1.6e-05 0.08 0.07 0.07 0.07 3.8e-04 1.0e-03 5.3e-04 9.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density1.52.77.52.72.0-2.02.0-2.0-1.71.7-2.3-1.01.0-0.00.00.3-1.2
Area under the delay curve1.32.04.5-0.50.8-0.80.8-0.8-1.21.40.2-1.71.72.0-2.0-2.11.7
BMI with tail0.20.81.8-1.2-1.41.4-1.11.10.9-1.00.70.7-0.7-0.30.30.20.4
BMI without tail0.21.22.10.10.8-0.80.9-0.9-1.11.0-0.5-1.31.31.5-1.5-1.41.3
Body weight0.00.10.30.20.2-0.20.4-0.4-0.40.3-0.3-0.40.40.4-0.4-0.30.5
Weight adjusted by age1.03.05.3-1.6-2.32.3-2.02.02.0-1.71.51.6-1.6-1.41.41.1-1.3
Bone surface0.20.51.91.20.7-0.70.6-0.6-0.40.3-1.4-0.0-0.0-0.40.40.6-0.8
Bone volume0.81.64.72.21.5-1.51.5-1.5-1.21.1-2.1-0.60.5-0.20.20.4-1.0
Breakpoint value in progressive ratio session0.20.41.00.61.0-1.00.6-0.6-0.70.5-0.4-0.60.60.7-0.7-0.50.5
Number of licking bursts0.20.81.30.70.6-0.61.0-1.0-1.11.0-1.0-1.01.00.8-0.8-0.70.4
Context. condit. distance diff. score0.40.51.40.90.6-0.60.6-0.6-0.61.2-0.4-0.80.70.1-0.1-0.2-1.2
Locomotion velocity, session 10.20.30.7-0.20.1-0.10.2-0.2-0.30.80.7-0.70.70.6-0.6-0.80.0
Locomotion distance, session 11.52.06.0-1.9-1.71.7-1.81.81.6-1.02.40.9-0.9-0.60.60.2-0.4
Locomotion velocity, session 22.12.65.0-2.2-2.12.1-2.02.01.9-1.61.91.2-1.2-0.70.70.30.1
Locomotion distance, session 21.41.94.0-2.0-1.71.7-1.71.71.6-1.51.71.1-1.1-0.50.50.30.6
Locomotion velocity, session 30.10.10.3-0.1-0.40.4-0.30.30.4-0.20.30.3-0.3-0.40.40.3-0.6
Locomotion distance, session 30.00.00.10.30.1-0.10.1-0.1-0.0-0.1-0.10.1-0.1-0.20.20.3-0.2
Stereotopy head waving bouts, day 30.40.50.90.60.8-0.80.9-0.9-0.90.7-1.0-0.70.70.6-0.6-0.50.3
Stereotopy head waving duration, day 30.50.70.90.30.8-0.80.8-0.8-0.90.9-0.6-0.90.90.9-0.9-0.90.5
Locomotion velocity, session 72.32.53.9-1.7-2.02.0-2.02.01.9-1.31.81.3-1.3-1.21.20.8-1.2
Locomotion distance, session 70.50.71.4-1.2-1.11.1-1.11.10.9-0.51.20.4-0.4-0.30.3-0.0-0.5
Stereotopy head waving bouts, day 70.10.20.4-0.10.3-0.30.3-0.3-0.30.50.3-0.50.50.4-0.4-0.60.2
Stereotopy head waving duration, day 70.10.10.6-0.3-0.30.3-0.30.30.3-0.10.80.2-0.2-0.40.40.1-0.5
Locomotion velocity, session 81.11.32.8-0.6-1.21.2-1.21.21.2-0.61.20.9-0.9-1.31.20.9-1.7
Locomotion distance, session 81.01.52.1-0.9-1.41.4-1.41.41.4-0.81.41.0-1.0-1.21.20.8-1.4
Degree of sensitization distance0.50.51.7-1.3-0.70.7-0.70.70.30.21.1-0.40.40.6-0.6-1.00.5
Degree of sensitization stereotypy0.00.00.4-0.3-0.10.1-0.20.20.20.00.6-0.0-0.0-0.10.1-0.1-0.0
Conditioned locomotion0.91.01.30.71.1-1.11.1-1.1-1.11.1-0.7-1.11.11.0-1.0-0.90.8
Cocaine response after cond. corrected0.40.61.1-0.20.5-0.50.5-0.5-0.60.6-0.1-0.80.81.1-1.1-1.01.1
Cocaine response after cond. not corrected0.20.30.7-0.50.1-0.10.0-0.0-0.10.30.4-0.50.50.7-0.7-0.80.8
Cocaine response before conditioning1.21.42.3-1.1-1.41.4-1.41.41.5-1.01.51.0-1.0-1.01.00.6-0.8
Saline control response0.60.81.1-0.7-1.01.0-1.01.01.0-0.71.10.8-0.8-0.90.90.6-0.6
Bone: connectivity density0.50.82.21.41.1-1.11.0-1.0-0.90.9-1.5-0.60.60.2-0.2-0.0-0.3
Bone: cortical apparent density4.57.110.1-2.6-3.23.2-3.13.13.2-2.92.62.7-2.7-2.12.11.8-1.2
Bone: cortical area0.10.20.4-0.1-0.40.4-0.30.30.5-0.3-0.10.4-0.4-0.50.50.4-0.7
Bone: cortical porosity0.60.61.71.31.0-1.01.0-1.0-0.80.6-1.3-0.30.3-0.10.10.3-0.5
Bone: cortical porosity0.60.72.01.41.0-1.01.0-1.0-0.80.8-1.1-0.40.4-0.20.20.3-0.9
Bone: cortical thickness0.10.20.7-0.1-0.40.4-0.40.40.5-0.20.10.3-0.3-0.50.50.3-0.8
Bone: cortical thickness0.00.10.2-0.3-0.20.2-0.20.20.20.20.3-0.10.1-0.00.0-0.2-0.5
Bone: cortical tissue density4.57.110.1-2.5-3.13.1-3.13.13.2-2.92.52.7-2.7-2.22.21.9-1.3
Condit. Reinf. active minus inactive responses2.93.39.0-0.90.6-0.60.6-0.6-1.12.11.0-2.42.42.6-2.6-3.01.7
Condit. Reinf. active-inactive response ratio3.63.810.0-0.70.8-0.80.8-0.8-1.42.51.0-2.72.72.7-2.7-3.21.5
Condit. Reinf. active responses1.11.54.6-1.00.1-0.10.1-0.1-0.51.30.9-1.61.61.7-1.7-2.10.9
Condit. Reinf. inactive responses0.40.51.1-1.0-1.01.0-0.90.90.8-0.80.80.6-0.6-0.30.30.1-0.2
Incentive salience index mean1.11.43.9-0.50.4-0.40.4-0.4-0.71.60.6-1.71.71.6-1.6-2.00.6
Condit. Reinf. lever presses0.10.10.70.3-0.10.1-0.10.10.10.40.1-0.20.1-0.30.30.1-0.9
Condit. Reinf. active minus inactive responses1.62.55.20.01.1-1.11.1-1.1-1.42.00.2-2.12.12.1-2.1-2.31.3
Condit. Reinf. active-inactive response ratio1.93.14.90.91.8-1.81.7-1.7-1.92.2-0.8-2.22.21.9-1.9-1.90.9
Condit. Reinf. active responses0.91.23.2-0.60.3-0.30.4-0.4-0.71.20.6-1.41.41.6-1.6-1.81.3
Condit. Reinf. inactive responses1.01.52.5-1.3-1.61.6-1.41.41.5-1.31.41.1-1.1-0.80.80.6-0.3
Condit. Reinf. lever presses0.50.81.40.20.7-0.70.7-0.7-0.81.1-0.1-1.21.21.1-1.1-1.20.9
Condit. Reinf. lever reinforcers received0.91.33.6-0.70.2-0.20.3-0.3-0.61.10.8-1.51.51.6-1.6-1.91.4
Conditioned reinforcement - actives0.10.30.8-0.50.1-0.1-0.00.0-0.20.50.2-0.70.70.8-0.8-0.90.9
Conditioned reinforcement - inactives0.41.12.3-1.0-1.21.2-1.51.51.4-1.01.00.9-0.9-0.80.80.6-0.7
Conditioned locomotion0.60.91.8-1.0-1.11.1-1.31.31.1-0.81.30.7-0.7-0.70.70.4-0.6
Patch foraging indifference point 0 sec0.61.62.3-0.4-1.51.5-1.21.21.4-1.50.41.5-1.5-1.41.41.5-0.5
Patch foraging indifference point AUC0.10.20.6-0.7-0.30.3-0.30.3-0.1-0.10.3-0.20.20.6-0.6-0.60.7
Delay disc. indifference point, 0s delay1.31.42.2-1.2-1.41.4-1.41.41.3-1.01.51.0-1.0-1.01.00.7-1.1
Delay disc. indifference point, 16s delay2.73.85.90.61.8-1.81.8-1.8-2.12.4-0.7-2.42.42.3-2.3-2.31.4
Delay disc. indifference point, 2s delay0.40.41.0-0.50.2-0.20.2-0.2-0.50.40.1-0.70.71.0-1.0-1.01.0
Delay disc. indifference point, 24s delay0.30.51.1-0.00.5-0.50.5-0.5-0.71.00.3-1.01.00.9-0.9-1.00.4
Delay disc. indifference point, 4s delay0.20.20.7-0.9-0.40.4-0.50.50.30.00.8-0.10.10.3-0.3-0.50.1
Delay disc. indifference point, 8s delay0.71.32.6-0.20.7-0.70.7-0.7-1.01.1-0.1-1.31.31.6-1.6-1.61.4
Indifference point function ln k0.20.71.1-0.6-0.90.9-1.01.01.1-1.00.70.9-0.9-0.70.70.7-0.3
Indifference point function log k0.20.71.1-0.6-0.90.9-1.01.01.1-1.00.70.9-0.9-0.70.70.7-0.3
Patch foraging total patch changes 0 sec0.31.01.6-0.4-1.21.2-0.90.91.1-1.30.21.2-1.2-1.11.11.1-0.1
Patch foraging total patch changes 12 sec0.71.01.7-0.1-1.01.0-0.80.81.0-1.00.31.1-1.1-1.31.31.2-1.0
Patch foraging total patch changes 18 sec0.10.20.9-0.5-0.60.6-0.40.40.2-0.50.10.2-0.10.2-0.2-0.11.0
Patch foraging total patch changes 24 sec0.31.11.6-0.4-1.11.1-1.01.01.0-1.30.11.2-1.2-1.21.21.2-0.6
Patch foraging total patch changes 6 sec0.20.30.6-0.2-0.70.7-0.50.50.6-0.8-0.20.7-0.7-0.50.50.60.2
Patch foraging time to switch 0 sec0.10.41.30.80.1-0.10.1-0.10.1-0.4-0.60.7-0.7-0.90.91.1-0.8
Patch foraging water rate 0 sec0.31.22.9-0.50.3-0.30.5-0.5-0.81.0-0.0-1.31.41.6-1.6-1.71.5
Patch foraging water rate 12 sec0.10.31.0-0.10.2-0.20.4-0.4-0.40.1-0.7-0.40.40.7-0.7-0.61.0
Patch foraging water rate 18 sec0.00.10.6-0.3-0.30.3-0.10.10.2-0.4-0.40.3-0.3-0.00.00.10.8
Patch foraging water rate 24 sec0.00.00.3-0.3-0.10.1-0.00.00.0-0.00.40.0-0.00.2-0.2-0.10.5
Patch foraging water rate 6 sec0.10.21.3-0.20.2-0.20.4-0.4-0.3-0.1-0.4-0.20.20.6-0.6-0.41.1
Seeking ratio, delayed vs. immediate footshock0.20.20.60.70.3-0.30.6-0.6-0.60.7-0.2-0.50.50.1-0.1-0.2-0.8
Distance traveled before self-admin0.40.82.41.60.9-0.90.9-0.9-0.40.3-1.50.1-0.2-0.70.70.9-1.1
Distance traveled after self-admin0.71.23.21.80.5-0.50.5-0.5-0.10.1-1.40.6-0.7-1.41.41.6-1.8
Extensor digitorum longus weight4.317.129.5-5.2-5.45.4-5.05.04.7-4.74.43.7-3.7-2.02.01.50.7
Bone: elastic displacement1.31.74.21.41.6-1.61.6-1.6-1.40.9-2.0-0.90.90.9-0.9-0.41.0
Bone: elastic work1.01.32.61.41.3-1.31.4-1.4-1.31.2-1.6-1.01.00.6-0.6-0.4-0.2
Bone: endosteal estimation0.10.10.50.50.5-0.50.5-0.5-0.40.3-0.7-0.20.20.1-0.1-0.00.0
Bone: endosteal perimeter0.10.10.20.30.4-0.40.4-0.4-0.40.3-0.5-0.40.40.3-0.3-0.30.3
Epididymis fat weight0.00.20.9-0.9-0.50.5-0.40.40.2-0.20.7-0.10.20.5-0.5-0.60.6
Delta time in closed arm before/after self-admin0.10.10.4-0.20.1-0.1-0.20.20.1-0.1-0.2-0.10.10.4-0.4-0.30.7
Delta time in open arm before/after self-admin0.60.71.61.30.9-0.91.0-1.0-1.01.0-1.2-0.70.70.2-0.2-0.1-0.3
Diff in mean of infusions in LGA sessions0.20.30.91.00.7-0.70.8-0.8-0.70.3-0.9-0.30.30.2-0.20.10.1
Delay discount exponential model param1.52.14.50.4-0.90.9-0.90.91.3-1.5-0.11.8-1.8-2.02.02.1-1.7
Extinction: sum of active levers before priming1.62.54.72.22.0-2.02.0-2.0-1.81.5-2.1-1.21.20.7-0.7-0.40.1
Active lever presses in extinction session 60.40.41.8-0.50.3-0.30.1-0.1-0.30.10.3-0.50.50.9-0.9-0.81.3
Bone: final force0.30.41.90.0-0.50.5-0.50.50.6-0.30.20.6-0.6-0.90.90.7-1.4
Bone: final moment0.20.41.60.0-0.50.5-0.40.40.5-0.30.10.5-0.5-0.80.80.7-1.3
Food consumed during 24 hour testing period0.10.31.1-1.0-0.40.4-0.60.60.3-0.11.0-0.10.10.4-0.4-0.60.3
Glucose0.81.31.91.11.4-1.41.4-1.4-1.30.9-1.2-0.91.00.9-0.9-0.61.2
Heart weight0.10.20.5-0.4-0.60.6-0.50.50.5-0.70.00.6-0.6-0.30.30.40.1
Delay discount hyperbolic model param1.41.84.00.5-0.80.8-0.70.71.1-1.3-0.21.6-1.6-1.91.92.0-1.7
Intermittent access intake day 1-15 change0.00.10.30.4-0.20.20.2-0.2-0.20.5-0.2-0.30.2-0.20.20.0-0.5
Intermittent access intake escalation0.00.10.40.4-0.20.20.3-0.3-0.20.4-0.4-0.20.2-0.20.20.1-0.6
Intermittent access intake escalation 20.10.20.50.70.1-0.10.5-0.5-0.50.6-0.5-0.40.40.1-0.1-0.1-0.3
Intermitt. access day 1 inactive lever presses0.00.30.80.90.3-0.30.2-0.2-0.1-0.0-0.80.3-0.4-0.60.60.8-0.4
Intermitt. access day 15 inactive lever presses0.10.60.8-0.1-0.70.7-0.90.90.8-0.7-0.10.8-0.8-0.90.90.9-0.7
Intermitt. access escalation Index0.10.30.8-0.5-0.30.3-0.00.0-0.30.60.9-0.70.60.5-0.5-0.9-0.5
Intermittent access day 1 total infusions1.02.96.50.01.4-1.41.2-1.2-1.51.5-0.7-1.91.92.3-2.3-2.22.6
Intermittent access day 15 total infusions0.30.61.10.10.5-0.50.6-0.6-0.80.9-0.4-1.01.01.0-1.0-1.01.0
Intermittent access terminal intake (last 3 days)0.20.41.2-0.10.2-0.20.3-0.3-0.50.5-0.4-0.70.70.8-0.8-0.81.1
Intermittent access total infusions0.70.92.30.20.8-0.80.7-0.7-0.90.8-0.7-1.01.01.1-1.1-1.01.5
Intermittent access day 1 locomotion0.20.30.9-0.7-0.20.2-0.40.40.20.00.7-0.30.30.6-0.6-0.71.0
Intermittent access day 15 total locomotion0.20.92.1-1.3-1.41.4-1.31.31.0-0.71.20.5-0.5-0.30.30.0-0.1
Intermittent access total locomotion0.40.41.0-1.0-0.90.9-1.01.00.7-0.40.90.2-0.20.1-0.1-0.20.4
Intermittent access standard deviation0.10.71.41.20.9-0.90.9-0.9-1.01.0-0.9-0.90.90.4-0.4-0.30.1
Left kidney weight0.00.30.90.4-0.20.2-0.10.10.3-0.3-0.50.6-0.6-0.80.80.8-0.9
Right kidney weight0.53.45.2-0.6-1.81.8-1.71.71.9-1.70.92.1-2.1-2.32.32.1-2.1
Cocaine induced anxiety0.51.32.0-0.4-0.90.9-1.11.11.2-1.30.61.4-1.4-1.41.41.4-1.1
Post-drug Anxiety0.70.81.1-0.8-1.01.0-1.01.01.0-1.01.00.9-0.9-0.80.80.6-1.0
Baseline Anxiety0.81.33.5-0.60.4-0.40.5-0.5-0.81.20.5-1.51.51.7-1.7-1.91.3
Tail length0.94.76.51.72.5-2.52.3-2.3-2.42.4-1.6-2.32.32.1-2.1-1.91.5
Length with tail0.41.72.91.71.7-1.71.6-1.6-1.51.4-1.3-1.11.10.7-0.7-0.50.3
Length without tail0.10.40.80.0-0.50.5-0.40.40.6-0.8-0.10.8-0.8-0.80.80.9-0.3
Times rat made contact with spout2.32.73.91.31.8-1.82.0-2.0-1.91.6-1.3-1.61.61.5-1.5-1.21.3
Lifetime Intake0.40.51.9-0.00.5-0.50.4-0.4-0.70.6-0.5-0.70.70.9-0.9-0.91.4
Liver weight, left0.81.32.71.31.4-1.41.5-1.5-1.30.8-1.6-0.80.80.8-0.8-0.41.1
Liver weight, right1.52.63.81.62.0-2.01.9-1.9-1.91.5-1.7-1.41.41.3-1.3-1.01.1
Locomotor activity0.20.30.50.50.7-0.70.7-0.7-0.50.4-0.3-0.40.40.4-0.4-0.30.2
Locomotor testing distance0.30.81.81.31.3-1.31.2-1.2-0.90.9-0.9-0.60.60.3-0.3-0.1-0.4
Locomotor testing rearing0.20.62.11.41.0-1.01.0-1.0-0.60.7-0.6-0.30.3-0.30.30.4-1.0
Locomotion in novel chamber2.33.17.8-2.8-2.22.2-2.22.21.9-1.92.51.2-1.2-0.20.2-0.00.8
Locomotion in novel chamber post-restriction0.20.71.7-1.3-1.21.2-0.90.90.8-1.00.90.6-0.6-0.20.20.10.4
Fecal boli incidents, locomotor time 10.10.30.7-0.40.0-0.0-0.00.0-0.30.40.1-0.60.60.7-0.7-0.80.8
Change in fecal boli incidents, locomotor task0.20.20.70.4-0.10.10.1-0.10.3-0.30.00.6-0.6-0.80.80.8-0.7
Time >=10cm from walls, locomotor time 10.80.91.7-1.3-1.31.3-1.21.21.1-1.10.60.9-0.9-0.50.50.40.2
Bouts of movement, locomotor time 12.12.78.8-1.9-0.00.0-0.10.1-0.40.71.3-1.51.62.4-2.4-2.63.0
Total resting periods, locomotor time 12.12.47.3-2.0-0.30.3-0.30.3-0.20.51.3-1.41.42.2-2.2-2.52.7
Rest time, locomotor task time 12.03.25.30.21.5-1.51.4-1.4-1.71.9-0.7-2.12.22.3-2.3-2.32.0
Distance moved, locomotor task time 10.30.71.2-0.9-1.01.0-1.01.01.1-1.10.70.9-0.9-0.50.50.5-0.3
Vertical activity count, locomotor time 10.10.51.90.3-0.30.3-0.40.40.5-0.40.30.7-0.7-1.01.00.9-1.4
Time >=10cm from walls, locomotor time 20.00.10.70.30.3-0.30.3-0.3-0.40.3-0.8-0.30.30.2-0.2-0.10.2
Bouts of movement, locomotor time 20.31.13.3-1.8-0.90.9-0.80.80.5-0.11.4-0.50.51.0-1.0-1.41.5
Total resting periods, locomotor time 20.20.93.0-1.7-0.90.9-0.80.80.6-0.21.3-0.30.30.8-0.8-1.11.3
Rest time, locomotor task time 20.40.71.20.70.9-0.91.1-1.1-0.80.8-0.9-0.90.90.7-0.7-0.60.9
Distance moved, locomotor task time 20.30.41.5-1.2-0.70.7-0.80.80.6-0.60.70.2-0.20.2-0.2-0.30.2
Vertical activity count, locomotor time 20.10.31.3-0.8-0.50.5-0.70.70.30.11.2-0.10.1-0.00.0-0.3-0.7
Light reinforcement 11.25.69.2-2.3-2.52.5-2.72.72.8-3.02.12.7-2.7-1.91.91.8-0.4
Light reinforcement 20.71.53.6-1.0-1.01.0-1.31.31.5-1.90.41.6-1.6-1.01.01.10.3
Bone: marrow area0.00.10.30.40.4-0.40.4-0.4-0.40.3-0.6-0.20.20.1-0.1-0.10.0
Bone: maximum diameter0.10.20.80.70.5-0.50.5-0.5-0.30.0-0.90.1-0.1-0.20.20.3-0.3
Bone: maximum force0.20.41.70.0-0.40.4-0.40.40.5-0.30.00.5-0.5-0.80.80.6-1.3
Bone: maximum moment0.20.31.4-0.1-0.50.5-0.40.40.5-0.30.00.4-0.5-0.70.70.5-1.2
Mean time between licks in bursts0.74.28.7-1.1-1.71.7-1.81.82.3-2.90.82.8-2.8-2.22.22.3-0.4
Mean num. licks in bursts0.00.10.2-0.30.1-0.1-0.20.20.3-0.30.50.2-0.20.0-0.00.00.5
Cd content in liver3.84.37.51.52.2-2.22.2-2.2-2.42.7-1.3-2.52.51.9-1.9-1.90.5
Co content in liver1.82.24.20.51.3-1.31.3-1.3-1.52.10.1-2.02.01.6-1.6-1.80.2
Cu content in liver0.70.92.1-0.10.5-0.50.5-0.5-0.71.40.9-1.41.31.1-1.1-1.40.1
Fe content in liver1.72.05.72.41.8-1.81.9-1.9-1.51.0-2.3-0.50.5-0.10.10.5-0.7
K content in liver1.21.22.6-0.8-1.21.2-1.11.11.2-1.60.31.4-1.4-1.01.01.1-0.1
Mg content in liver0.40.40.6-0.1-0.60.6-0.50.50.6-0.80.10.8-0.8-0.80.80.8-0.6
Mn content in liver0.80.91.2-0.6-0.90.9-1.01.01.1-1.10.61.1-1.1-1.01.00.9-0.8
Na content in liver1.51.74.12.00.2-0.20.7-0.7-0.2-0.2-1.80.9-0.9-1.71.72.0-1.8
Rb content in liver2.32.78.9-2.9-1.91.9-1.91.91.5-0.93.00.3-0.30.5-0.5-1.00.7
Se content in liver0.10.10.3-0.5-0.20.2-0.30.30.3-0.40.10.3-0.30.0-0.00.00.6
Sr content in liver0.20.21.20.60.4-0.40.4-0.4-0.3-0.2-1.10.2-0.2-0.10.10.40.2
Zn content in liver0.00.00.10.00.1-0.10.2-0.2-0.20.30.3-0.30.30.2-0.2-0.30.1
Bone: minimum diameter0.20.40.6-0.5-0.80.8-0.70.70.8-0.60.30.6-0.6-0.60.60.4-0.5
Time in familiar zone, hab. session 12.12.33.10.91.6-1.61.7-1.7-1.71.5-1.0-1.61.61.6-1.6-1.41.4
Time in novel zone, hab. session 10.10.10.40.40.3-0.30.3-0.3-0.20.1-0.6-0.00.0-0.10.10.2-0.2
Total zone transitions, hab. session 11.82.53.9-0.9-1.61.6-1.61.61.7-1.41.31.6-1.7-1.81.81.5-2.0
Total locomotion distance, hab. session 11.01.42.8-1.7-1.41.4-1.51.51.4-1.11.60.9-0.9-0.50.50.2-0.5
Locomotion velocity, hab. session 11.52.12.9-1.5-1.71.7-1.71.71.7-1.51.41.5-1.4-1.21.20.9-0.9
Time in familiar zone, hab. session 20.20.30.60.80.6-0.60.7-0.7-0.50.1-0.8-0.10.10.0-0.00.20.5
Time in novel zone, hab. session 20.10.10.4-0.20.1-0.10.0-0.0-0.20.60.1-0.60.60.5-0.5-0.6-0.1
Total zone transitions, hab. session 20.20.30.9-0.7-0.60.6-0.60.60.5-0.51.00.4-0.4-0.20.20.20.2
Total locomotion distance, hab. session 20.60.82.7-1.6-0.80.8-0.90.90.6-0.41.6-0.00.00.6-0.6-0.81.2
Locomotion velocity, hab. session 20.70.92.9-1.6-1.01.0-1.11.10.9-0.81.70.4-0.40.2-0.2-0.40.7
Novel to familiar place preference ratio2.12.73.70.81.5-1.51.6-1.6-1.81.8-1.1-1.91.91.9-1.9-1.81.5
Novelty place preference2.22.83.80.81.5-1.51.7-1.7-1.81.8-1.2-2.02.01.9-1.9-1.81.5
Time in novel zone, NPP test2.83.54.61.01.8-1.81.9-1.9-2.12.0-1.5-2.12.12.1-2.1-1.91.5
Total zone transitions, NPP test0.81.23.8-1.5-1.31.3-1.31.31.2-0.82.00.7-0.7-0.40.40.1-0.1
Total locomotion distance, NPP test0.60.82.8-1.6-1.11.1-1.11.10.9-0.61.70.3-0.30.1-0.1-0.40.6
Locomotion velocity, NPP test1.21.84.1-1.9-1.71.7-1.61.61.5-1.32.01.0-1.0-0.50.50.20.3
Intraocular pressure0.61.02.4-1.6-1.31.3-1.21.21.1-1.01.50.6-0.6-0.10.1-0.00.2
Delta distance traveled before/after self-admin0.30.30.5-0.1-0.70.7-0.60.60.5-0.40.20.6-0.6-0.70.70.6-0.6
Delta ambulatory time before/after self-admin0.30.50.9-0.4-1.01.0-0.90.90.8-0.70.30.7-0.7-0.70.70.6-0.5
Parametrial fat weight0.00.00.10.30.1-0.10.2-0.2-0.2-0.2-0.20.2-0.2-0.10.10.30.3
Pavlov. Cond. lever latency0.10.21.2-0.5-0.00.0-0.20.20.2-0.70.10.3-0.30.2-0.2-0.01.1
Pavlov. Cond. magazine entry latency0.20.30.50.40.5-0.50.5-0.5-0.60.7-0.2-0.70.70.5-0.5-0.50.5
Pavlov. Cond. change in total contacts0.40.51.3-0.20.1-0.10.3-0.3-0.51.10.2-1.11.00.9-0.9-1.10.1
Pavlov. Cond. index score0.40.51.20.70.6-0.60.7-0.7-0.81.1-0.4-0.90.90.5-0.5-0.60.0
Pavlov. Cond. latency score0.30.41.20.70.5-0.50.6-0.6-0.71.1-0.3-0.80.80.4-0.4-0.5-0.3
Pavlov. Cond. lever contacts0.10.10.60.4-0.10.10.1-0.1-0.10.60.0-0.30.3-0.10.1-0.0-0.8
Pavlov. Cond. magazine entry number0.60.81.5-0.7-0.90.9-0.90.91.0-1.20.51.1-1.1-0.80.80.9-0.3
Pavlov. Cond. intertrial magazine entries0.20.20.7-0.4-0.00.00.1-0.1-0.20.30.2-0.50.60.7-0.7-0.80.5
Pavlov. Cond. lever-magazine prob. diff.0.40.51.10.40.5-0.50.6-0.6-0.71.0-0.2-1.01.00.7-0.7-0.80.4
Pavlov. Cond. response bias0.30.41.00.60.5-0.50.7-0.7-0.71.0-0.4-0.90.80.5-0.5-0.60.1
Pavlov. Cond. lever latency0.00.00.1-0.2-0.20.2-0.20.20.2-0.30.00.2-0.2-0.10.10.10.1
Pavlov. Cond. magazine entry latency0.30.51.0-0.2-0.70.7-0.60.60.7-0.40.80.6-0.6-0.90.80.7-1.0
Pavlov. Cond. change in total contacts0.20.61.30.70.8-0.80.9-0.9-0.81.1-0.4-0.90.90.6-0.6-0.6-0.2
Pavlov. Cond. index score0.00.00.10.30.1-0.10.1-0.1-0.10.20.1-0.10.1-0.10.10.0-0.3
Pavlov. Cond. latency score0.00.00.1-0.0-0.10.1-0.10.10.1-0.00.30.1-0.1-0.20.20.1-0.3
Pavlov. Cond. lever contacts0.20.30.40.60.6-0.60.7-0.7-0.60.6-0.4-0.50.50.3-0.3-0.30.0
Pavlov. Cond. magazine entry number0.10.10.6-0.10.2-0.20.2-0.2-0.30.1-0.4-0.20.30.5-0.5-0.40.8
Pavlov. Cond. intertrial magazine entries0.51.03.4-1.8-1.01.0-1.01.00.6-0.51.4-0.10.10.8-0.8-1.01.3
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.1-0.00.00.0-0.00.00.10.2-0.00.0-0.10.10.0-0.3
Pavlov. Cond. response bias0.10.20.70.80.2-0.20.3-0.3-0.10.3-0.20.0-0.1-0.50.50.5-0.9
Time in closed arm before self-admin1.62.73.81.21.7-1.71.9-1.9-2.01.9-1.0-1.91.91.6-1.6-1.50.9
Time in closed arm after self-admin0.30.40.80.40.6-0.60.5-0.5-0.70.9-0.2-0.90.90.6-0.6-0.7-0.2
Time in open arm before self-admin1.82.23.3-1.8-1.71.7-1.81.81.7-1.81.41.6-1.5-0.90.90.80.1
Time in open arm after self-admin0.30.30.80.5-0.00.00.0-0.00.2-0.2-0.50.5-0.5-0.80.80.9-0.7
Bone: periosteal estimation0.00.10.50.50.3-0.30.3-0.3-0.20.2-0.7-0.10.1-0.10.20.2-0.5
Bone: periosteal perimeter0.20.50.80.60.8-0.80.8-0.8-0.70.6-0.9-0.70.70.6-0.6-0.50.5
Bone: post-yield work0.20.41.2-0.2-0.60.6-0.50.50.6-0.40.50.5-0.5-0.70.70.5-1.1
Progressive ratio test 1 active lever presses0.20.41.4-1.2-0.40.4-0.70.70.5-0.30.9-0.10.10.5-0.5-0.61.1
Progressive ratio test 1 breakpoint0.20.41.4-1.1-0.30.3-0.60.60.4-0.20.8-0.10.20.6-0.6-0.71.2
Progressive ratio test 1 inactive lever presses0.30.81.3-0.6-1.01.0-1.11.11.0-0.80.61.0-1.0-1.01.00.9-0.5
Progressive ratio test 2 active lever presses0.71.02.2-1.5-1.31.3-1.21.21.2-0.91.30.7-0.7-0.40.30.10.1
Progressive ratio test 2 breakpoint0.70.92.3-1.5-1.31.3-1.21.21.1-0.81.30.6-0.6-0.20.2-0.00.2
Progressive ratio test 2 inactive lever presses0.31.01.7-1.0-1.21.2-1.31.31.2-0.90.80.9-0.9-0.90.90.6-0.7
Incentive Sensitization - Responses0.20.50.8-0.4-0.90.9-0.50.50.7-0.70.40.8-0.8-0.90.90.8-0.7
Incentive Sensitization - Breakpoint0.30.71.1-0.5-1.01.0-0.70.70.8-0.80.50.9-0.9-1.01.00.8-0.8
Sum of active levers in priming session hrs 5-61.21.13.71.31.3-1.31.2-1.2-1.10.4-1.9-0.30.30.5-0.40.11.0
Progressive ratio0.20.72.0-0.9-0.10.10.0-0.0-0.10.41.1-0.70.81.2-1.2-1.31.4
Food seeking constrained by brief footshock0.40.51.1-1.0-1.01.0-0.80.80.7-0.70.60.4-0.40.1-0.1-0.00.6
Seeking ratio, punishment vs. effort0.30.71.40.1-0.60.6-0.70.70.7-0.9-0.51.1-1.1-1.11.11.2-0.7
Retroperitoneal fat weight0.21.12.2-1.4-1.51.5-1.31.31.2-0.91.30.8-0.7-0.50.50.2-0.1
Reaction time number correct0.10.51.6-1.3-1.01.0-0.80.80.8-0.41.10.2-0.2-0.00.0-0.3-0.1
Reaction time mean minus median0.10.82.01.41.3-1.31.0-1.0-1.20.5-1.4-0.30.30.1-0.10.20.4
Reaction time mean minus median AUC0.10.41.11.01.0-1.00.7-0.7-0.90.5-0.8-0.40.30.1-0.10.10.2
Reaction time num false alarms0.61.02.4-1.6-1.41.4-1.21.21.1-1.01.20.6-0.5-0.10.1-0.10.6
Reaction time num false alarms AUC0.61.42.6-1.6-1.61.6-1.41.41.4-1.31.21.0-0.9-0.50.50.30.3
Reaction time trials correct on left0.10.51.6-1.3-1.01.0-0.80.80.8-0.41.10.2-0.2-0.00.0-0.3-0.1
Reaction time trials on left0.10.51.4-1.2-1.01.0-0.70.70.7-0.41.00.2-0.2-0.00.0-0.3-0.1
Reaction time mean1.12.54.41.92.1-2.11.9-1.9-2.01.6-1.4-1.41.41.0-0.9-0.70.6
Reaction time mean AUC0.92.23.71.71.9-1.91.8-1.8-1.91.6-1.1-1.41.41.0-1.0-0.80.7
Median of all reaction times1.82.94.71.82.2-2.22.1-2.1-2.11.9-1.2-1.71.71.2-1.2-1.00.6
Reaction time omissions0.20.41.31.10.6-0.60.4-0.4-0.3-0.1-0.60.4-0.4-0.70.70.9-0.6
Reaction time false alarm rate0.50.71.2-0.9-1.01.0-0.90.91.0-1.10.60.9-0.8-0.50.50.50.3
Reaction time premature initiation rate0.00.00.10.00.1-0.1-0.00.0-0.00.2-0.3-0.30.30.2-0.2-0.30.2
Reaction time premature initiations0.00.10.2-0.4-0.30.3-0.20.20.20.10.1-0.20.20.3-0.3-0.40.1
Std. dev. reaction times0.41.33.61.91.6-1.61.4-1.4-1.50.8-1.8-0.50.50.1-0.10.30.1
Reaction time trials completed0.10.51.4-1.2-1.01.0-0.70.70.7-0.41.00.2-0.2-0.00.0-0.3-0.1
Reaction time trials AUC0.10.41.2-1.1-0.90.9-0.70.70.7-0.40.90.2-0.2-0.00.0-0.2-0.1
Run reversals in cocaine runway, females0.20.20.5-0.6-0.30.3-0.00.0-0.10.10.6-0.40.40.6-0.6-0.70.4
Run reversals in cocaine runway, males0.40.51.6-1.3-0.90.9-0.80.80.6-0.60.80.1-0.10.4-0.4-0.60.7
Latency to leave start box in cocaine runway1.42.03.0-1.4-1.71.7-1.51.51.5-1.31.51.3-1.3-1.21.20.8-1.3
Latency to leave start box in cocaine runway, F1.21.42.3-0.5-1.01.0-0.90.91.3-1.30.41.4-1.4-1.51.51.3-1.5
Latency to leave start box in cocaine runway, M2.12.06.1-2.1-2.02.0-1.71.71.3-0.82.50.5-0.5-0.20.2-0.3-0.2
Std. dev. time between licks in bursts0.10.30.8-0.2-0.30.3-0.30.30.5-0.9-0.10.8-0.8-0.50.50.60.3
Total sessions with >9 infusions0.20.30.8-0.9-0.50.5-0.70.70.5-0.50.30.2-0.20.1-0.1-0.20.9
Short access day 1 total inactive lever presses0.51.01.7-1.0-1.21.2-1.21.21.3-1.20.71.0-1.0-0.80.80.7-0.2
Short access day 10 total inactive lever presses0.00.10.40.3-0.10.1-0.00.00.2-0.2-0.20.3-0.3-0.50.50.5-0.7
Short access day 1 total infusions0.61.22.2-1.5-1.41.4-1.51.51.3-1.30.81.0-1.0-0.50.50.40.6
Short access day 10 total infusions1.62.77.4-0.60.9-0.90.7-0.7-1.31.3-0.3-1.81.92.4-2.4-2.42.7
Short access total infusions0.50.73.0-0.90.1-0.1-0.00.0-0.30.40.1-0.70.81.2-1.2-1.21.7
Short access day 1 locomotion0.81.32.6-1.5-1.31.3-1.61.61.3-1.21.10.9-0.9-0.50.50.3-0.1
Short access day 10 total locomotion0.00.10.3-0.4-0.40.4-0.50.50.30.00.5-0.10.10.2-0.2-0.30.2
Short access total locomotion0.91.33.0-1.7-1.41.4-1.61.61.3-0.81.70.5-0.5-0.10.1-0.20.0
One hour access (0.3 mA shock)2.63.14.80.61.4-1.41.5-1.5-1.81.8-1.1-2.12.12.2-2.2-2.02.2
Compulsive drug intake0.30.40.7-0.1-0.60.6-0.30.30.6-0.80.10.8-0.8-0.80.80.9-0.7
One hour access (shock baseline)0.82.13.20.51.3-1.31.2-1.2-1.41.5-0.7-1.71.71.8-1.8-1.71.8
Social response proportion0.20.30.50.50.7-0.70.7-0.7-0.70.5-0.5-0.50.50.4-0.4-0.30.3
Social responses0.40.51.10.91.1-1.10.9-0.9-0.80.6-0.7-0.40.40.3-0.3-0.10.3
Social time1.92.94.52.12.1-2.12.1-2.1-2.02.0-1.9-1.61.60.8-0.8-0.7-0.7
Soleus weight1.23.65.4-1.7-2.32.3-2.12.12.1-2.31.32.1-2.1-1.61.61.5-0.4
Bone: stiffness0.81.53.7-0.4-1.11.1-1.11.11.2-0.90.81.2-1.2-1.51.51.2-1.9
Tibialis anterior weight2.38.013.6-3.6-3.73.7-3.53.53.2-3.42.72.6-2.6-1.41.41.10.7
Time to tail flick, vehicle, before self-admin0.60.81.91.41.1-1.11.0-1.0-1.10.9-1.1-0.70.70.4-0.4-0.10.3
Time to tail flick, vehicle, after self-admin0.30.71.40.91.0-1.00.9-0.9-1.01.2-0.5-1.01.00.6-0.6-0.6-0.2
Time to tail flick, test, before self-admin1.21.34.7-2.2-1.21.2-1.31.31.2-1.11.80.5-0.50.2-0.2-0.51.0
Time to tail flick, test, after self-admin0.20.20.6-0.7-0.20.2-0.20.2-0.10.20.5-0.40.40.5-0.5-0.70.6
Delta time to tail flick, vehicle, before/after SA0.00.00.1-0.10.1-0.10.1-0.1-0.20.30.2-0.30.30.1-0.1-0.3-0.4
Delta time to tail flick, test, before/after SA0.70.81.61.20.9-0.91.0-1.0-1.11.3-1.2-0.90.90.4-0.4-0.3-0.4
Tibia length0.30.82.71.50.7-0.70.6-0.6-0.30.3-1.00.2-0.3-0.90.91.0-1.6
Ambulatory time before self-admin0.30.82.31.51.0-1.01.1-1.1-0.60.5-1.4-0.20.1-0.30.30.5-0.9
Ambulatory time after self-admin0.71.12.80.9-0.30.3-0.20.20.6-0.6-0.81.1-1.1-1.51.51.7-1.6
Bone: tissue strength0.10.10.2-0.3-0.20.2-0.20.20.10.20.4-0.20.20.2-0.2-0.3-0.2
Total heroin consumption2.02.44.10.71.7-1.71.4-1.4-1.51.3-1.0-1.51.51.9-1.9-1.52.0
Bone: trabecular number1.12.16.02.41.8-1.81.7-1.7-1.51.7-1.9-1.01.00.0-0.00.1-1.3
Bone: trabecular spacing1.31.94.6-2.1-1.81.8-1.81.81.5-1.12.20.8-0.8-0.30.3-0.00.3
Bone: trabecular thickness3.14.37.62.82.6-2.62.6-2.6-2.42.4-2.5-1.81.80.9-0.9-0.6-0.5
Bone: trabecular tissue density0.71.31.8-0.6-1.01.0-1.11.11.2-1.20.91.3-1.3-1.31.31.2-1.2
Water consumed over 24 hours0.30.71.6-0.20.3-0.30.5-0.5-0.71.10.3-1.21.21.1-1.1-1.30.4
Number of responses in last shaping day0.00.00.30.30.0-0.00.2-0.2-0.2-0.1-0.50.1-0.1-0.10.10.30.2