Hub : Genes

LOC120093741

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio XR_005487425.2 0.03 0.03 1.6e-03 0.02 0.01 0.01 0.01 1.5e-03 8.6e-03 1.0e-02 1.1e-02
2 Adipose isoform ratio XR_010053115.1 0.03 0.03 1.6e-03 0.02 0.01 0.01 0.01 1.4e-03 8.4e-03 4.8e-02 1.0e-02
3 Adipose gene expression LOC120093741 0.02 0.01 7.5e-03 0.02 0.02 0.01 0.02 5.3e-03 6.1e-03 6.8e-03 6.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.00.00.2-0.20.2
Area under the delay curve0.20.30.4-0.60.6-0.4
BMI with tail0.82.62.7-1.61.6-1.6
BMI without tail0.21.31.6-1.01.0-1.3
Body weight0.31.21.3-1.11.1-1.2
Weight adjusted by age1.33.83.9-2.02.0-1.9
Bone surface0.00.00.00.1-0.1-0.2
Bone volume0.00.00.1-0.10.1-0.2
Breakpoint value in progressive ratio session0.10.20.30.5-0.50.6
Number of licking bursts0.00.00.0-0.20.2-0.2
Context. condit. distance diff. score0.10.10.10.3-0.3-0.0
Locomotion velocity, session 10.70.80.90.9-0.90.7
Locomotion distance, session 10.10.10.20.4-0.40.2
Locomotion velocity, session 20.40.50.60.8-0.80.6
Locomotion distance, session 20.81.11.31.1-1.10.9
Locomotion velocity, session 31.31.51.61.3-1.31.2
Locomotion distance, session 32.42.72.81.7-1.71.6
Stereotopy head waving bouts, day 31.31.61.9-1.21.2-1.4
Stereotopy head waving duration, day 30.00.00.1-0.00.0-0.3
Locomotion velocity, session 72.12.32.51.6-1.61.4
Locomotion distance, session 73.44.34.52.1-2.12.0
Stereotopy head waving bouts, day 75.46.36.7-2.62.6-2.3
Stereotopy head waving duration, day 73.54.34.6-2.12.1-1.9
Locomotion velocity, session 80.10.10.2-0.10.1-0.4
Locomotion distance, session 81.01.41.71.3-1.30.9
Degree of sensitization distance0.00.00.1-0.20.2-0.3
Degree of sensitization stereotypy4.75.25.7-2.42.4-2.0
Conditioned locomotion0.81.01.21.1-1.10.7
Cocaine response after cond. corrected0.40.60.6-0.80.8-0.7
Cocaine response after cond. not corrected0.10.20.2-0.40.4-0.5
Cocaine response before conditioning1.21.51.71.3-1.31.0
Saline control response0.40.60.70.8-0.80.5
Bone: connectivity density0.30.40.40.7-0.70.6
Bone: cortical apparent density1.32.02.4-1.31.3-1.5
Bone: cortical area0.10.10.2-0.30.3-0.4
Bone: cortical porosity1.31.41.61.2-1.21.1
Bone: cortical porosity1.81.92.11.4-1.41.3
Bone: cortical thickness0.00.10.1-0.20.2-0.2
Bone: cortical thickness0.30.40.50.7-0.70.6
Bone: cortical tissue density1.21.92.3-1.31.3-1.5
Condit. Reinf. active minus inactive responses0.10.10.1-0.30.3-0.2
Condit. Reinf. active-inactive response ratio0.00.00.00.1-0.10.2
Condit. Reinf. active responses0.00.00.0-0.00.00.0
Condit. Reinf. inactive responses0.10.10.10.3-0.30.1
Incentive salience index mean0.30.40.4-0.70.7-0.5
Condit. Reinf. lever presses0.60.90.9-1.01.0-0.9
Condit. Reinf. active minus inactive responses0.30.50.6-0.70.7-0.6
Condit. Reinf. active-inactive response ratio0.20.40.4-0.60.6-0.5
Condit. Reinf. active responses0.10.10.2-0.40.4-0.2
Condit. Reinf. inactive responses0.10.10.10.3-0.30.3
Condit. Reinf. lever presses0.91.31.31.1-1.11.1
Condit. Reinf. lever reinforcers received0.00.00.10.1-0.10.3
Conditioned reinforcement - actives0.10.50.70.7-0.70.9
Conditioned reinforcement - inactives0.41.21.31.1-1.11.1
Conditioned locomotion0.81.21.31.0-1.01.2
Patch foraging indifference point 0 sec0.10.40.40.7-0.70.5
Patch foraging indifference point AUC0.20.60.7-0.70.7-0.8
Delay disc. indifference point, 0s delay0.20.20.2-0.50.5-0.3
Delay disc. indifference point, 16s delay0.00.00.0-0.20.2-0.0
Delay disc. indifference point, 2s delay6.26.97.0-2.62.6-2.6
Delay disc. indifference point, 24s delay0.00.00.0-0.20.20.0
Delay disc. indifference point, 4s delay0.40.40.5-0.70.7-0.5
Delay disc. indifference point, 8s delay0.10.10.10.3-0.30.3
Indifference point function ln k0.00.00.00.1-0.10.1
Indifference point function log k0.00.00.00.1-0.10.1
Patch foraging total patch changes 0 sec0.30.80.91.0-1.00.8
Patch foraging total patch changes 12 sec0.20.20.30.5-0.50.4
Patch foraging total patch changes 18 sec0.10.20.20.5-0.50.4
Patch foraging total patch changes 24 sec0.00.10.10.3-0.30.2
Patch foraging total patch changes 6 sec0.00.10.10.3-0.30.2
Patch foraging time to switch 0 sec0.10.30.4-0.60.6-0.5
Patch foraging water rate 0 sec0.10.20.30.4-0.40.5
Patch foraging water rate 12 sec0.10.30.40.4-0.40.6
Patch foraging water rate 18 sec0.20.30.40.6-0.60.6
Patch foraging water rate 24 sec0.10.10.10.3-0.30.3
Patch foraging water rate 6 sec0.00.00.00.1-0.10.2
Seeking ratio, delayed vs. immediate footshock0.00.10.1-0.30.3-0.2
Distance traveled before self-admin0.10.30.30.5-0.50.5
Distance traveled after self-admin2.84.95.02.2-2.22.2
Extensor digitorum longus weight6.023.826.0-4.84.8-5.1
Bone: elastic displacement3.54.54.62.1-2.12.1
Bone: elastic work3.14.04.12.0-2.02.0
Bone: endosteal estimation0.00.00.0-0.00.0-0.2
Bone: endosteal perimeter0.30.70.8-0.80.8-0.9
Epididymis fat weight1.57.78.62.7-2.72.9
Delta time in closed arm before/after self-admin0.20.20.20.5-0.50.5
Delta time in open arm before/after self-admin2.63.13.11.8-1.81.7
Diff in mean of infusions in LGA sessions0.30.50.6-0.80.8-0.7
Delay discount exponential model param0.30.50.60.7-0.70.5
Extinction: sum of active levers before priming0.50.80.9-0.90.9-0.8
Active lever presses in extinction session 60.90.91.00.9-0.91.0
Bone: final force0.00.00.10.1-0.10.3
Bone: final moment0.10.10.20.3-0.30.5
Food consumed during 24 hour testing period0.51.01.10.9-0.91.1
Glucose0.10.20.20.4-0.40.5
Heart weight0.50.80.90.9-0.90.9
Delay discount hyperbolic model param0.50.70.80.9-0.90.7
Intermittent access intake day 1-15 change0.42.02.11.4-1.41.4
Intermittent access intake escalation0.10.70.80.9-0.90.9
Intermittent access intake escalation 20.30.50.50.7-0.70.7
Intermitt. access day 1 inactive lever presses0.00.00.0-0.10.1-0.1
Intermitt. access day 15 inactive lever presses0.00.10.10.3-0.30.2
Intermitt. access escalation Index1.13.43.6-1.91.9-1.8
Intermittent access day 1 total infusions0.20.50.60.8-0.80.5
Intermittent access day 15 total infusions0.30.80.91.0-1.00.7
Intermittent access terminal intake (last 3 days)0.30.50.60.8-0.80.5
Intermittent access total infusions0.50.50.70.8-0.80.4
Intermittent access day 1 locomotion0.81.41.61.3-1.31.0
Intermittent access day 15 total locomotion1.34.95.02.2-2.22.1
Intermittent access total locomotion2.63.13.41.8-1.81.6
Intermittent access standard deviation0.63.03.11.8-1.81.7
Left kidney weight0.10.60.6-0.80.8-0.7
Right kidney weight0.32.02.1-1.51.5-1.4
Cocaine induced anxiety0.00.10.10.3-0.30.1
Post-drug Anxiety0.40.40.40.7-0.70.7
Baseline Anxiety0.00.10.1-0.30.3-0.1
Tail length0.00.10.10.4-0.4-0.0
Length with tail0.00.00.1-0.10.1-0.3
Length without tail0.00.00.0-0.10.1-0.0
Times rat made contact with spout0.30.40.50.6-0.60.7
Lifetime Intake1.21.51.91.4-1.40.9
Liver weight, left0.00.00.1-0.10.1-0.2
Liver weight, right0.00.10.10.3-0.30.1
Locomotor activity0.10.10.10.4-0.40.2
Locomotor testing distance0.10.30.40.6-0.60.3
Locomotor testing rearing0.20.60.80.9-0.90.4
Locomotion in novel chamber0.81.11.2-1.01.0-1.1
Locomotion in novel chamber post-restriction0.41.21.31.1-1.11.1
Fecal boli incidents, locomotor time 11.13.03.01.7-1.71.7
Change in fecal boli incidents, locomotor task0.80.91.1-0.80.8-1.1
Time >=10cm from walls, locomotor time 10.40.50.50.7-0.70.6
Bouts of movement, locomotor time 10.00.00.1-0.30.3-0.0
Total resting periods, locomotor time 10.00.00.10.0-0.00.2
Rest time, locomotor task time 10.10.20.20.4-0.40.4
Distance moved, locomotor task time 10.10.20.2-0.50.5-0.4
Vertical activity count, locomotor time 10.10.70.9-0.80.8-1.0
Time >=10cm from walls, locomotor time 20.10.20.20.5-0.50.4
Bouts of movement, locomotor time 20.41.31.4-1.11.1-1.2
Total resting periods, locomotor time 20.52.22.4-1.41.4-1.6
Rest time, locomotor task time 20.00.00.0-0.10.1-0.2
Distance moved, locomotor task time 20.00.10.1-0.30.3-0.2
Vertical activity count, locomotor time 20.00.00.1-0.20.2-0.3
Light reinforcement 10.00.00.10.0-0.00.2
Light reinforcement 20.10.20.2-0.50.5-0.5
Bone: marrow area0.00.00.00.1-0.1-0.1
Bone: maximum diameter0.10.10.1-0.30.3-0.4
Bone: maximum force0.00.10.1-0.30.3-0.3
Bone: maximum moment0.00.00.0-0.00.0-0.1
Mean time between licks in bursts0.10.60.60.8-0.80.7
Mean num. licks in bursts0.30.80.90.9-0.90.9
Cd content in liver0.20.20.30.6-0.6-0.2
Co content in liver0.50.61.0-0.60.6-1.0
Cu content in liver0.00.00.0-0.20.20.1
Fe content in liver0.00.10.1-0.10.1-0.4
K content in liver0.20.20.3-0.50.5-0.2
Mg content in liver0.20.20.30.4-0.40.5
Mn content in liver0.00.00.0-0.10.1-0.1
Na content in liver0.20.20.3-0.50.5-0.4
Rb content in liver0.50.60.80.7-0.70.9
Se content in liver0.50.60.60.8-0.80.6
Sr content in liver0.10.10.10.4-0.40.0
Zn content in liver0.70.81.00.8-0.81.0
Bone: minimum diameter0.10.20.2-0.40.4-0.5
Time in familiar zone, hab. session 10.30.40.60.5-0.50.8
Time in novel zone, hab. session 11.41.61.9-1.21.2-1.4
Total zone transitions, hab. session 10.91.21.3-1.11.1-1.1
Total locomotion distance, hab. session 10.00.00.00.0-0.00.1
Locomotion velocity, hab. session 10.00.00.00.1-0.10.1
Time in familiar zone, hab. session 21.31.51.91.2-1.21.4
Time in novel zone, hab. session 21.21.31.7-1.01.0-1.3
Total zone transitions, hab. session 20.20.30.30.6-0.60.6
Total locomotion distance, hab. session 20.40.50.60.7-0.70.8
Locomotion velocity, hab. session 20.50.70.80.8-0.80.9
Novel to familiar place preference ratio2.33.03.3-1.71.7-1.8
Novelty place preference1.92.42.8-1.51.5-1.7
Time in novel zone, NPP test2.02.42.6-1.51.5-1.6
Total zone transitions, NPP test0.30.50.60.6-0.60.7
Total locomotion distance, NPP test1.31.92.21.3-1.31.5
Locomotion velocity, NPP test1.42.02.11.4-1.41.4
Intraocular pressure2.33.84.32.1-2.11.7
Delta distance traveled before/after self-admin5.35.95.92.4-2.42.4
Delta ambulatory time before/after self-admin3.05.15.22.3-2.32.3
Parametrial fat weight1.53.53.71.9-1.91.8
Pavlov. Cond. lever latency0.81.01.11.0-1.00.9
Pavlov. Cond. magazine entry latency2.02.52.8-1.71.7-1.4
Pavlov. Cond. change in total contacts2.62.83.1-1.81.8-1.5
Pavlov. Cond. index score3.34.24.5-2.12.1-1.8
Pavlov. Cond. latency score2.93.74.1-2.02.0-1.8
Pavlov. Cond. lever contacts0.91.11.2-1.11.1-0.9
Pavlov. Cond. magazine entry number1.51.92.11.5-1.51.2
Pavlov. Cond. intertrial magazine entries2.53.03.21.8-1.81.5
Pavlov. Cond. lever-magazine prob. diff.3.03.74.1-2.02.0-1.7
Pavlov. Cond. response bias0.50.70.8-0.90.9-0.7
Pavlov. Cond. lever latency1.11.61.9-1.21.2-1.4
Pavlov. Cond. magazine entry latency1.31.82.21.3-1.31.5
Pavlov. Cond. change in total contacts0.51.11.3-1.21.2-0.8
Pavlov. Cond. index score0.71.11.41.0-1.01.2
Pavlov. Cond. latency score0.50.91.10.8-0.81.1
Pavlov. Cond. lever contacts1.31.82.11.3-1.31.4
Pavlov. Cond. magazine entry number0.70.91.3-0.90.9-1.1
Pavlov. Cond. intertrial magazine entries0.81.72.01.4-1.41.1
Pavlov. Cond. lever-magazine prob. diff.0.50.71.00.8-0.81.0
Pavlov. Cond. response bias1.52.12.61.4-1.41.6
Time in closed arm before self-admin2.13.73.8-1.91.9-1.9
Time in closed arm after self-admin1.82.02.1-1.41.4-1.4
Time in open arm before self-admin0.60.70.7-0.80.8-0.8
Time in open arm after self-admin0.10.10.10.4-0.40.4
Bone: periosteal estimation0.00.10.1-0.30.3-0.3
Bone: periosteal perimeter0.61.21.5-1.01.0-1.2
Bone: post-yield work0.00.10.10.2-0.20.3
Progressive ratio test 1 active lever presses2.34.04.32.1-2.11.8
Progressive ratio test 1 breakpoint2.64.54.82.2-2.22.0
Progressive ratio test 1 inactive lever presses0.00.10.10.3-0.30.1
Progressive ratio test 2 active lever presses0.40.50.70.8-0.80.4
Progressive ratio test 2 breakpoint0.20.20.30.6-0.60.2
Progressive ratio test 2 inactive lever presses0.51.51.81.3-1.31.0
Incentive Sensitization - Responses0.30.71.0-0.70.7-1.0
Incentive Sensitization - Breakpoint0.40.91.2-0.90.9-1.1
Sum of active levers in priming session hrs 5-60.00.00.0-0.20.2-0.2
Progressive ratio0.00.10.10.3-0.30.3
Food seeking constrained by brief footshock0.40.50.70.7-0.70.8
Seeking ratio, punishment vs. effort0.00.00.0-0.00.00.1
Retroperitoneal fat weight2.511.211.43.4-3.43.3
Reaction time number correct0.31.21.31.1-1.11.1
Reaction time mean minus median0.00.30.50.5-0.50.7
Reaction time mean minus median AUC0.00.30.50.4-0.40.7
Reaction time num false alarms0.00.00.0-0.10.1-0.2
Reaction time num false alarms AUC0.10.30.3-0.50.5-0.5
Reaction time trials correct on left0.31.21.31.1-1.11.1
Reaction time trials on left0.41.21.41.1-1.11.2
Reaction time mean0.10.30.30.6-0.60.4
Reaction time mean AUC0.10.20.30.5-0.50.4
Median of all reaction times0.10.20.30.6-0.60.3
Reaction time omissions0.20.40.70.5-0.50.8
Reaction time false alarm rate1.11.51.5-1.21.2-1.2
Reaction time premature initiation rate1.11.71.81.3-1.31.3
Reaction time premature initiations1.03.13.41.7-1.71.8
Std. dev. reaction times0.10.20.30.4-0.40.5
Reaction time trials completed0.41.21.41.1-1.11.2
Reaction time trials AUC0.20.80.90.8-0.80.9
Run reversals in cocaine runway, females0.20.30.40.6-0.60.3
Run reversals in cocaine runway, males1.41.61.7-1.21.2-1.3
Latency to leave start box in cocaine runway0.71.01.0-1.01.0-1.0
Latency to leave start box in cocaine runway, F0.40.50.5-0.70.7-0.7
Latency to leave start box in cocaine runway, M1.00.91.0-1.01.0-0.9
Std. dev. time between licks in bursts0.20.50.60.6-0.60.8
Total sessions with >9 infusions0.50.60.70.9-0.90.5
Short access day 1 total inactive lever presses0.40.70.90.9-0.90.7
Short access day 10 total inactive lever presses0.00.20.2-0.40.4-0.5
Short access day 1 total infusions1.02.02.21.5-1.51.2
Short access day 10 total infusions0.10.20.30.5-0.50.2
Short access total infusions2.02.83.21.8-1.81.4
Short access day 1 locomotion0.20.30.40.6-0.60.3
Short access day 10 total locomotion0.10.40.50.7-0.70.4
Short access total locomotion0.71.01.31.1-1.10.8
One hour access (0.3 mA shock)0.00.00.0-0.10.1-0.1
Compulsive drug intake0.30.50.6-0.70.7-0.8
One hour access (shock baseline)0.00.00.00.0-0.00.0
Social response proportion0.70.91.11.0-1.00.8
Social responses0.00.00.00.0-0.0-0.0
Social time0.30.50.70.8-0.80.5
Soleus weight0.00.10.1-0.30.3-0.2
Bone: stiffness0.61.21.2-1.11.1-1.1
Tibialis anterior weight7.626.229.7-5.05.0-5.5
Time to tail flick, vehicle, before self-admin0.00.00.0-0.00.0-0.2
Time to tail flick, vehicle, after self-admin0.40.80.9-0.90.9-0.9
Time to tail flick, test, before self-admin0.20.20.2-0.40.4-0.4
Time to tail flick, test, after self-admin0.30.30.3-0.50.5-0.6
Delta time to tail flick, vehicle, before/after SA0.00.00.00.1-0.10.2
Delta time to tail flick, test, before/after SA0.00.00.1-0.20.2-0.3
Tibia length0.20.70.70.8-0.80.9
Ambulatory time before self-admin0.20.80.80.9-0.90.9
Ambulatory time after self-admin3.55.55.72.3-2.32.4
Bone: tissue strength0.00.00.0-0.20.2-0.2
Total heroin consumption0.70.91.00.9-0.91.0
Bone: trabecular number0.40.70.90.8-0.81.0
Bone: trabecular spacing0.40.70.7-0.80.8-0.8
Bone: trabecular thickness0.20.20.2-0.50.5-0.5
Bone: trabecular tissue density2.34.04.1-2.02.0-1.9
Water consumed over 24 hours0.81.51.61.2-1.21.2
Number of responses in last shaping day0.10.20.2-0.50.5-0.3