Hub : Genes

LOC120093741

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose isoform ratio XR_005487425.2 0.03 0.03 1.6e-03 0.02 0.01 0.01 0.01 1.5e-03 8.6e-03 1.0e-02 1.1e-02
2 Adipose isoform ratio XR_010053115.1 0.03 0.03 1.6e-03 0.02 0.01 0.01 0.01 1.4e-03 8.4e-03 4.8e-02 1.0e-02
3 Adipose gene expression LOC120093741 0.02 0.01 7.5e-03 0.02 0.02 0.01 0.01 5.3e-03 6.1e-03 6.8e-03 6.9e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.00.00.0-0.20.2-0.2
Area under the delay curve0.30.30.40.6-0.60.4
BMI with tail0.82.62.71.6-1.61.6
BMI without tail0.41.31.61.0-1.01.3
Body weight0.31.21.31.1-1.11.2
Weight adjusted by age2.53.83.92.0-2.01.9
Bone surface0.00.00.0-0.10.10.2
Bone volume0.00.00.10.1-0.10.2
Breakpoint value in progressive ratio session0.20.20.3-0.50.5-0.6
Number of licking bursts0.00.00.00.2-0.20.2
Context. condit. distance diff. score0.10.10.1-0.30.30.0
Locomotion velocity, session 10.70.80.9-0.90.9-0.7
Locomotion distance, session 10.10.10.2-0.40.4-0.2
Locomotion velocity, session 20.40.50.6-0.80.8-0.6
Locomotion distance, session 20.81.11.3-1.11.1-0.9
Locomotion velocity, session 31.31.51.6-1.31.3-1.2
Locomotion distance, session 32.52.72.8-1.71.7-1.6
Stereotopy head waving bouts, day 31.41.61.91.2-1.21.4
Stereotopy head waving duration, day 30.00.00.10.0-0.00.3
Locomotion velocity, session 72.12.32.5-1.61.6-1.4
Locomotion distance, session 73.44.34.5-2.12.1-2.0
Stereotopy head waving bouts, day 75.66.36.72.6-2.62.3
Stereotopy head waving duration, day 73.64.34.62.1-2.11.9
Locomotion velocity, session 80.10.10.20.1-0.10.4
Locomotion distance, session 81.01.41.7-1.31.3-0.9
Degree of sensitization distance0.00.00.10.2-0.20.3
Degree of sensitization stereotypy4.85.25.72.4-2.42.0
Conditioned locomotion0.91.01.2-1.11.1-0.7
Cocaine response after cond. corrected0.50.60.60.8-0.80.7
Cocaine response after cond. not corrected0.20.20.20.4-0.40.5
Cocaine response before conditioning1.21.51.7-1.31.3-1.0
Saline control response0.40.60.7-0.80.8-0.5
Bone: connectivity density0.30.40.4-0.70.7-0.6
Bone: cortical apparent density1.52.02.41.3-1.31.5
Bone: cortical area0.10.10.20.3-0.30.4
Bone: cortical porosity1.31.41.6-1.21.2-1.1
Bone: cortical porosity1.81.92.1-1.41.4-1.3
Bone: cortical thickness0.00.10.10.2-0.20.2
Bone: cortical thickness0.30.40.5-0.70.7-0.6
Bone: cortical tissue density1.41.92.31.3-1.31.5
Condit. Reinf. active minus inactive responses0.10.10.10.3-0.30.2
Condit. Reinf. active-inactive response ratio0.00.00.0-0.10.1-0.2
Condit. Reinf. active responses0.00.00.00.0-0.0-0.0
Condit. Reinf. inactive responses0.10.10.1-0.30.3-0.1
Incentive salience index mean0.30.40.40.7-0.70.5
Condit. Reinf. lever presses0.60.90.91.0-1.00.9
Condit. Reinf. active minus inactive responses0.40.50.60.7-0.70.6
Condit. Reinf. active-inactive response ratio0.30.40.40.6-0.60.5
Condit. Reinf. active responses0.10.10.20.4-0.40.2
Condit. Reinf. inactive responses0.10.10.1-0.30.3-0.3
Condit. Reinf. lever presses0.91.31.3-1.11.1-1.1
Condit. Reinf. lever reinforcers received0.00.00.1-0.10.1-0.3
Conditioned reinforcement - actives0.30.50.7-0.70.7-0.9
Conditioned reinforcement - inactives0.81.21.3-1.11.1-1.1
Conditioned locomotion0.91.21.3-1.01.0-1.2
Patch foraging indifference point 0 sec0.20.40.4-0.70.7-0.5
Patch foraging indifference point AUC0.40.60.70.7-0.70.8
Delay disc. indifference point, 0s delay0.20.20.20.5-0.50.3
Delay disc. indifference point, 16s delay0.00.00.00.2-0.20.0
Delay disc. indifference point, 2s delay6.26.97.02.6-2.62.6
Delay disc. indifference point, 24s delay0.00.00.00.2-0.2-0.0
Delay disc. indifference point, 4s delay0.40.40.50.7-0.70.5
Delay disc. indifference point, 8s delay0.10.10.1-0.30.3-0.3
Indifference point function ln k0.00.00.0-0.10.1-0.1
Indifference point function log k0.00.00.0-0.10.1-0.1
Patch foraging total patch changes 0 sec0.50.80.9-1.01.0-0.8
Patch foraging total patch changes 12 sec0.20.20.3-0.50.5-0.4
Patch foraging total patch changes 18 sec0.10.20.2-0.50.5-0.4
Patch foraging total patch changes 24 sec0.10.10.1-0.30.3-0.2
Patch foraging total patch changes 6 sec0.00.10.1-0.30.3-0.2
Patch foraging time to switch 0 sec0.20.30.40.6-0.60.5
Patch foraging water rate 0 sec0.10.20.3-0.40.4-0.5
Patch foraging water rate 12 sec0.10.30.4-0.40.4-0.6
Patch foraging water rate 18 sec0.20.30.4-0.60.6-0.6
Patch foraging water rate 24 sec0.10.10.1-0.30.3-0.3
Patch foraging water rate 6 sec0.00.00.0-0.10.1-0.2
Seeking ratio, delayed vs. immediate footshock0.10.10.10.3-0.30.2
Distance traveled before self-admin0.20.30.3-0.50.5-0.5
Distance traveled after self-admin4.04.95.0-2.22.2-2.2
Extensor digitorum longus weight6.023.826.04.8-4.85.1
Bone: elastic displacement3.94.54.6-2.12.1-2.1
Bone: elastic work3.14.04.1-2.02.0-2.0
Bone: endosteal estimation0.00.00.00.0-0.00.2
Bone: endosteal perimeter0.30.70.80.8-0.80.9
Epididymis fat weight2.37.78.6-2.72.7-2.9
Delta time in closed arm before/after self-admin0.20.20.2-0.50.5-0.5
Delta time in open arm before/after self-admin3.13.13.1-1.81.8-1.7
Diff in mean of infusions in LGA sessions0.40.50.60.8-0.80.7
Delay discount exponential model param0.40.50.6-0.70.7-0.5
Extinction: sum of active levers before priming0.80.80.90.9-0.90.8
Active lever presses in extinction session 60.90.91.0-0.90.9-1.0
Bone: final force0.00.00.1-0.10.1-0.3
Bone: final moment0.10.10.2-0.30.3-0.5
Food consumed during 24 hour testing period0.71.01.1-0.90.9-1.1
Glucose0.10.20.2-0.40.4-0.5
Heart weight0.50.80.9-0.90.9-0.9
Delay discount hyperbolic model param0.60.70.8-0.90.9-0.7
Intermittent access intake day 1-15 change1.02.02.1-1.41.4-1.4
Intermittent access intake escalation0.40.70.8-0.90.9-0.9
Intermittent access intake escalation 20.40.50.5-0.70.7-0.7
Intermitt. access day 1 inactive lever presses0.00.00.00.1-0.10.1
Intermitt. access day 15 inactive lever presses0.00.10.1-0.30.3-0.2
Intermitt. access escalation Index2.43.43.61.9-1.91.8
Intermittent access day 1 total infusions0.30.50.6-0.80.8-0.5
Intermittent access day 15 total infusions0.50.80.9-1.01.0-0.7
Intermittent access terminal intake (last 3 days)0.40.50.6-0.80.8-0.5
Intermittent access total infusions0.50.50.7-0.80.8-0.4
Intermittent access day 1 locomotion1.11.41.6-1.31.3-1.0
Intermittent access day 15 total locomotion2.74.95.0-2.22.2-2.1
Intermittent access total locomotion2.63.13.4-1.81.8-1.6
Intermittent access standard deviation1.43.03.1-1.81.8-1.7
Left kidney weight0.10.60.60.8-0.80.7
Right kidney weight0.42.02.11.5-1.51.4
Cocaine induced anxiety0.00.10.1-0.30.3-0.1
Post-drug Anxiety0.40.40.4-0.70.7-0.7
Baseline Anxiety0.00.10.10.3-0.30.1
Tail length0.00.10.1-0.40.40.0
Length with tail0.00.00.10.1-0.10.3
Length without tail0.00.00.00.1-0.10.0
Times rat made contact with spout0.30.40.5-0.60.6-0.7
Lifetime Intake1.31.51.9-1.41.4-0.9
Liver weight, left0.00.00.10.1-0.10.2
Liver weight, right0.00.10.1-0.30.3-0.1
Locomotor activity0.10.10.1-0.40.4-0.2
Locomotor testing distance0.10.30.4-0.60.6-0.3
Locomotor testing rearing0.30.60.8-0.90.9-0.4
Locomotion in novel chamber0.81.11.21.0-1.01.1
Locomotion in novel chamber post-restriction0.81.21.3-1.11.1-1.1
Fecal boli incidents, locomotor time 12.03.03.0-1.71.7-1.7
Change in fecal boli incidents, locomotor task0.90.91.10.8-0.81.1
Time >=10cm from walls, locomotor time 10.40.50.5-0.70.7-0.6
Bouts of movement, locomotor time 10.00.00.10.3-0.30.0
Total resting periods, locomotor time 10.00.00.1-0.00.0-0.2
Rest time, locomotor task time 10.10.20.2-0.40.4-0.4
Distance moved, locomotor task time 10.10.20.20.5-0.50.4
Vertical activity count, locomotor time 10.30.70.90.8-0.81.0
Time >=10cm from walls, locomotor time 20.20.20.2-0.50.5-0.4
Bouts of movement, locomotor time 20.81.31.41.1-1.11.2
Total resting periods, locomotor time 21.32.22.41.4-1.41.6
Rest time, locomotor task time 20.00.00.00.1-0.10.2
Distance moved, locomotor task time 20.00.10.10.3-0.30.2
Vertical activity count, locomotor time 20.00.00.10.2-0.20.3
Light reinforcement 10.00.00.1-0.00.0-0.2
Light reinforcement 20.20.20.20.5-0.50.5
Bone: marrow area0.00.00.0-0.10.10.1
Bone: maximum diameter0.10.10.10.3-0.30.4
Bone: maximum force0.00.10.10.3-0.30.3
Bone: maximum moment0.00.00.00.0-0.00.1
Mean time between licks in bursts0.30.60.6-0.80.8-0.7
Mean num. licks in bursts0.50.80.9-0.90.9-0.9
Cd content in liver0.20.20.3-0.60.60.2
Co content in liver0.50.61.00.6-0.61.0
Cu content in liver0.00.00.00.2-0.2-0.1
Fe content in liver0.00.10.10.1-0.10.4
K content in liver0.20.20.30.5-0.50.2
Mg content in liver0.20.20.3-0.40.4-0.5
Mn content in liver0.00.00.00.1-0.10.1
Na content in liver0.20.20.30.5-0.50.4
Rb content in liver0.50.60.8-0.70.7-0.9
Se content in liver0.50.60.6-0.80.8-0.6
Sr content in liver0.10.10.1-0.40.4-0.0
Zn content in liver0.70.81.0-0.80.8-1.0
Bone: minimum diameter0.10.20.20.4-0.40.5
Time in familiar zone, hab. session 10.40.40.6-0.50.5-0.8
Time in novel zone, hab. session 11.61.61.91.2-1.21.4
Total zone transitions, hab. session 10.91.21.31.1-1.11.1
Total locomotion distance, hab. session 10.00.00.0-0.00.0-0.1
Locomotion velocity, hab. session 10.00.00.0-0.10.1-0.1
Time in familiar zone, hab. session 21.41.51.9-1.21.2-1.4
Time in novel zone, hab. session 21.31.31.71.0-1.01.3
Total zone transitions, hab. session 20.20.30.3-0.60.6-0.6
Total locomotion distance, hab. session 20.40.50.6-0.70.7-0.8
Locomotion velocity, hab. session 20.50.70.8-0.80.8-0.9
Novel to familiar place preference ratio2.73.03.31.7-1.71.8
Novelty place preference2.32.42.81.5-1.51.7
Time in novel zone, NPP test2.22.42.61.5-1.51.6
Total zone transitions, NPP test0.30.50.6-0.60.6-0.7
Total locomotion distance, NPP test1.41.92.2-1.31.3-1.5
Locomotion velocity, NPP test1.42.02.1-1.41.4-1.4
Intraocular pressure2.73.84.3-2.12.1-1.7
Delta distance traveled before/after self-admin5.55.95.9-2.42.4-2.4
Delta ambulatory time before/after self-admin4.25.15.2-2.32.3-2.3
Parametrial fat weight1.53.53.7-1.91.9-1.8
Pavlov. Cond. lever latency0.81.01.1-1.01.0-0.9
Pavlov. Cond. magazine entry latency2.02.52.81.7-1.71.4
Pavlov. Cond. change in total contacts2.72.83.11.8-1.81.5
Pavlov. Cond. index score3.34.24.52.1-2.11.8
Pavlov. Cond. latency score3.03.74.12.0-2.01.8
Pavlov. Cond. lever contacts0.91.11.21.1-1.10.9
Pavlov. Cond. magazine entry number1.51.92.1-1.51.5-1.2
Pavlov. Cond. intertrial magazine entries2.53.03.2-1.81.8-1.5
Pavlov. Cond. lever-magazine prob. diff.3.03.74.12.0-2.01.7
Pavlov. Cond. response bias0.50.70.80.9-0.90.7
Pavlov. Cond. lever latency1.21.61.91.2-1.21.4
Pavlov. Cond. magazine entry latency1.51.82.2-1.31.3-1.5
Pavlov. Cond. change in total contacts0.71.11.31.2-1.20.8
Pavlov. Cond. index score0.81.11.4-1.01.0-1.2
Pavlov. Cond. latency score0.60.91.1-0.80.8-1.1
Pavlov. Cond. lever contacts1.31.82.1-1.31.3-1.4
Pavlov. Cond. magazine entry number0.80.91.30.9-0.91.1
Pavlov. Cond. intertrial magazine entries1.11.72.0-1.41.4-1.1
Pavlov. Cond. lever-magazine prob. diff.0.50.71.0-0.80.8-1.0
Pavlov. Cond. response bias1.62.12.6-1.41.4-1.6
Time in closed arm before self-admin2.93.73.81.9-1.91.9
Time in closed arm after self-admin1.92.02.11.4-1.41.4
Time in open arm before self-admin0.60.70.70.8-0.80.8
Time in open arm after self-admin0.10.10.1-0.40.4-0.4
Bone: periosteal estimation0.00.10.10.3-0.30.3
Bone: periosteal perimeter0.71.21.51.0-1.01.2
Bone: post-yield work0.00.10.1-0.20.2-0.3
Progressive ratio test 1 active lever presses3.24.04.3-2.12.1-1.8
Progressive ratio test 1 breakpoint3.74.54.8-2.22.2-2.0
Progressive ratio test 1 inactive lever presses0.00.10.1-0.30.3-0.1
Progressive ratio test 2 active lever presses0.40.50.7-0.80.8-0.4
Progressive ratio test 2 breakpoint0.20.20.3-0.60.6-0.2
Progressive ratio test 2 inactive lever presses0.91.51.8-1.31.3-1.0
Incentive Sensitization - Responses0.50.71.00.7-0.71.0
Incentive Sensitization - Breakpoint0.70.91.20.9-0.91.1
Sum of active levers in priming session hrs 5-60.00.00.00.2-0.20.2
Progressive ratio0.10.10.1-0.30.3-0.3
Food seeking constrained by brief footshock0.40.50.7-0.70.7-0.8
Seeking ratio, punishment vs. effort0.00.00.00.0-0.0-0.1
Retroperitoneal fat weight2.611.211.4-3.43.4-3.3
Reaction time number correct0.61.21.3-1.11.1-1.1
Reaction time mean minus median0.10.30.5-0.50.5-0.7
Reaction time mean minus median AUC0.10.30.5-0.40.4-0.7
Reaction time num false alarms0.00.00.00.1-0.10.2
Reaction time num false alarms AUC0.20.30.30.5-0.50.5
Reaction time trials correct on left0.61.21.3-1.11.1-1.1
Reaction time trials on left0.61.21.4-1.11.1-1.2
Reaction time mean0.20.30.3-0.60.6-0.4
Reaction time mean AUC0.10.20.3-0.50.5-0.4
Median of all reaction times0.20.20.3-0.60.6-0.3
Reaction time omissions0.30.40.7-0.50.5-0.8
Reaction time false alarm rate1.11.51.51.2-1.21.2
Reaction time premature initiation rate1.21.71.8-1.31.3-1.3
Reaction time premature initiations1.83.13.4-1.71.7-1.8
Std. dev. reaction times0.10.20.3-0.40.4-0.5
Reaction time trials completed0.61.21.4-1.11.1-1.2
Reaction time trials AUC0.40.80.9-0.80.8-0.9
Run reversals in cocaine runway, females0.30.30.4-0.60.6-0.3
Run reversals in cocaine runway, males1.51.61.71.2-1.21.3
Latency to leave start box in cocaine runway0.91.01.01.0-1.01.0
Latency to leave start box in cocaine runway, F0.40.50.50.7-0.70.7
Latency to leave start box in cocaine runway, M1.00.91.01.0-1.00.9
Std. dev. time between licks in bursts0.30.50.6-0.60.6-0.8
Total sessions with >9 infusions0.50.60.7-0.90.9-0.5
Short access day 1 total inactive lever presses0.60.70.9-0.90.9-0.7
Short access day 10 total inactive lever presses0.10.20.20.4-0.40.5
Short access day 1 total infusions1.52.02.2-1.51.5-1.2
Short access day 10 total infusions0.20.20.3-0.50.5-0.2
Short access total infusions2.22.83.2-1.81.8-1.4
Short access day 1 locomotion0.20.30.4-0.60.6-0.3
Short access day 10 total locomotion0.20.40.5-0.70.7-0.4
Short access total locomotion0.91.01.3-1.11.1-0.8
One hour access (0.3 mA shock)0.00.00.00.1-0.10.1
Compulsive drug intake0.40.50.60.7-0.70.8
One hour access (shock baseline)0.00.00.0-0.00.0-0.0
Social response proportion0.80.91.1-1.01.0-0.8
Social responses0.00.00.0-0.00.00.0
Social time0.40.50.7-0.80.8-0.5
Soleus weight0.00.10.10.3-0.30.2
Bone: stiffness0.71.21.21.1-1.11.1
Tibialis anterior weight7.726.229.75.0-5.05.5
Time to tail flick, vehicle, before self-admin0.00.00.00.0-0.00.2
Time to tail flick, vehicle, after self-admin0.60.80.90.9-0.90.9
Time to tail flick, test, before self-admin0.20.20.20.4-0.40.4
Time to tail flick, test, after self-admin0.30.30.30.5-0.50.6
Delta time to tail flick, vehicle, before/after SA0.00.00.0-0.10.1-0.2
Delta time to tail flick, test, before/after SA0.00.00.10.2-0.20.3
Tibia length0.20.70.7-0.80.8-0.9
Ambulatory time before self-admin0.50.80.8-0.90.9-0.9
Ambulatory time after self-admin4.75.55.7-2.32.3-2.4
Bone: tissue strength0.00.00.00.2-0.20.2
Total heroin consumption0.70.91.0-0.90.9-1.0
Bone: trabecular number0.40.70.9-0.80.8-1.0
Bone: trabecular spacing0.50.70.70.8-0.80.8
Bone: trabecular thickness0.20.20.20.5-0.50.5
Bone: trabecular tissue density2.74.04.12.0-2.01.9
Water consumed over 24 hours1.11.51.6-1.21.2-1.2
Number of responses in last shaping day0.20.20.20.5-0.50.3