Hub : Genes

LOC120093559

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC120093559	0.07	0.04	1.2e-03	0.04	0.04	0.03	0.03	3.9e-03	2.2e-03	6.5e-03	9.9e-03
2	LHb	gene expression	LOC120093559	0.27	0.14	3.9e-03	0.05	0.04	0.06	0.03	2.9e-02	3.5e-02	1.6e-02	6.4e-02
3	NAcc	intron excision ratio	chr7_29545175_29548381	0.04	0.02	4.5e-05	0.03	0.04	0.03	0.03	3.0e-04	2.9e-05	2.8e-04	5.2e-04
4	PL	gene expression	LOC120093559	0.08	0.03	2.0e-09	0.05	0.08	0.09	0.08	2.0e-06	2.7e-09	9.4e-10	5.6e-09
5	Brain	gene expression	LOC120093559	0.04	0.02	1.4e-03	0.03	0.02	0.02	0.02	5.1e-04	2.8e-03	8.4e-03	9.6e-03
6	NAcc	gene expression	LOC120093559	0.08	0.04	2.2e-07	0.06	0.06	0.06	0.06	7.0e-08	5.9e-07	4.2e-07	1.7e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	0.1	0.1	0.3	0.3	-0.0	0.0	0.0	-0.6	-0.4
Area under the delay curve	1.3	1.3	4.1	-1.1	0.8	0.4	0.1	1.4	2.0
BMI with tail	0.5	1.6	4.6	-0.3	-2.1	-1.3	-1.6	0.6	0.5
BMI without tail	2.0	4.1	8.1	2.1	-2.8	-2.3	-2.2	-1.0	-0.9
Body weight	6.3	26.4	40.0	5.7	-6.3	-5.8	-5.4	-3.5	-3.2
Weight adjusted by age	0.2	0.2	0.3	0.0	0.2	-0.5	-0.5	-0.6	-0.4
Bone surface	0.0	0.1	0.2	0.1	-0.3	-0.4	-0.3	-0.2	-0.0
Bone volume	0.1	0.1	0.2	0.2	-0.3	-0.4	-0.2	-0.3	-0.2
Breakpoint value in progressive ratio session	2.0	2.2	3.7	-1.9	1.2	1.3	1.0	1.7	1.6
Number of licking bursts	0.3	0.3	1.0	-0.3	-1.0	-0.5	-0.7	0.0	-0.1
Context. condit. distance diff. score	0.1	0.1	0.5	0.7	0.1	-0.2	0.3	-0.1	-0.0
Locomotion velocity, session 1	0.5	0.5	1.2	-1.1	1.0	0.4	0.4	0.5	0.4
Locomotion distance, session 1	0.2	0.2	0.6	-0.8	0.2	-0.1	-0.4	0.6	0.3
Locomotion velocity, session 2	0.2	0.2	0.4	0.7	0.3	0.7	0.6	0.1	-0.1
Locomotion distance, session 2	0.2	0.3	1.0	-0.2	-0.6	-0.5	-1.0	0.3	0.0
Locomotion velocity, session 3	0.4	0.4	1.3	0.4	1.1	0.6	0.9	0.1	0.0
Locomotion distance, session 3	0.1	0.1	0.2	-0.1	0.0	-0.1	-0.2	0.5	0.2
Stereotopy head waving bouts, day 3	0.1	0.2	0.5	0.2	0.4	0.7	0.5	-0.2	0.0
Stereotopy head waving duration, day 3	0.2	0.2	0.4	0.4	0.6	0.5	0.7	-0.4	0.1
Locomotion velocity, session 7	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.2	0.4	-0.2
Locomotion distance, session 7	0.1	0.2	0.3	-0.5	0.5	0.4	0.1	0.5	0.2
Stereotopy head waving bouts, day 7	0.2	0.3	0.7	0.7	0.1	-0.1	0.2	-0.6	-0.8
Stereotopy head waving duration, day 7	0.0	0.0	0.1	0.1	0.2	0.1	0.3	-0.2	-0.3
Locomotion velocity, session 8	0.3	0.3	1.1	1.1	-0.0	-0.2	0.1	-0.8	-0.5
Locomotion distance, session 8	0.6	0.8	1.7	0.9	-1.0	-1.3	-1.3	-0.1	-0.2
Degree of sensitization distance	0.2	0.2	0.3	-0.4	0.5	0.5	0.5	0.2	0.4
Degree of sensitization stereotypy	0.2	0.2	0.6	0.1	0.5	0.5	0.8	0.2	-0.2
Conditioned locomotion	0.1	0.1	0.3	0.1	0.3	0.5	0.6	0.2	0.1
Cocaine response after cond. corrected	0.2	0.2	0.5	0.7	-0.4	-0.4	-0.1	-0.6	0.1
Cocaine response after cond. not corrected	0.3	0.3	0.5	0.7	-0.5	-0.7	-0.4	-0.7	0.1
Cocaine response before conditioning	0.1	0.1	0.2	-0.3	0.1	-0.4	-0.4	-0.1	-0.2
Saline control response	0.8	1.1	1.9	1.4	-0.8	-0.8	-0.8	-1.0	-1.3
Bone: connectivity density	0.1	0.2	0.6	0.4	0.2	0.3	0.4	-0.7	-0.5
Bone: cortical apparent density	0.1	0.2	0.3	0.5	-0.4	-0.5	-0.4	-0.2	-0.3
Bone: cortical area	0.7	1.0	2.6	0.5	-1.1	-1.3	-1.6	-0.6	-0.1
Bone: cortical porosity	0.2	0.3	1.0	1.0	0.2	0.1	0.2	-0.6	-0.2
Bone: cortical porosity	0.1	0.1	0.5	0.7	0.1	-0.1	-0.1	-0.5	-0.1
Bone: cortical thickness	0.7	1.2	2.1	1.0	-0.8	-1.1	-1.5	-1.2	-0.6
Bone: cortical thickness	0.1	0.2	0.3	-0.4	0.5	0.5	0.3	-0.0	0.4
Bone: cortical tissue density	0.1	0.1	0.2	0.5	-0.4	-0.5	-0.3	-0.2	-0.3
Condit. Reinf. active minus inactive responses	0.8	0.9	3.7	-1.9	1.0	0.5	0.4	0.5	0.3
Condit. Reinf. active-inactive response ratio	1.0	1.0	3.8	-2.0	0.9	0.7	0.5	0.7	0.6
Condit. Reinf. active responses	0.9	1.1	4.0	-2.0	1.1	0.8	0.6	0.5	0.3
Condit. Reinf. inactive responses	0.4	0.5	0.8	-0.9	0.8	0.9	0.7	0.4	0.3
Incentive salience index mean	0.4	0.5	1.9	-1.4	0.3	-0.4	-0.7	-0.3	-0.5
Condit. Reinf. lever presses	0.4	0.5	1.1	-0.4	-0.2	-0.8	-1.1	-0.7	-0.8
Condit. Reinf. active minus inactive responses	0.4	0.5	1.6	-1.3	0.6	0.7	0.2	0.6	0.2
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.0	-0.2	0.2	0.2	-0.0	-0.1	-0.1
Condit. Reinf. active responses	0.5	0.7	2.3	-1.5	0.6	0.7	0.4	0.9	0.2
Condit. Reinf. inactive responses	1.1	1.3	2.7	-1.7	1.1	1.0	1.0	1.2	0.8
Condit. Reinf. lever presses	0.1	0.2	0.4	-0.5	0.1	0.6	0.2	0.4	-0.5
Condit. Reinf. lever reinforcers received	0.7	0.9	3.0	-1.7	0.6	0.8	0.4	1.1	0.4
Conditioned reinforcement - actives	1.6	1.6	2.3	1.3	-0.8	-1.5	-1.1	-1.5	-1.3
Conditioned reinforcement - inactives	1.2	1.4	2.5	1.6	-0.6	-1.3	-0.8	-1.4	-1.0
Conditioned locomotion	1.9	2.2	3.0	1.7	-1.1	-1.5	-1.4	-1.6	-1.5
Patch foraging indifference point 0 sec	0.1	0.2	0.7	0.8	-0.2	-0.0	0.2	-0.3	-0.4
Patch foraging indifference point AUC	0.9	1.0	1.6	1.2	-0.8	-0.7	-0.9	-1.2	-1.2
Delay disc. indifference point, 0s delay	0.3	0.3	0.9	-0.5	0.2	0.3	0.1	0.7	0.9
Delay disc. indifference point, 16s delay	1.8	1.8	5.9	-1.2	0.5	0.4	0.1	1.8	2.4
Delay disc. indifference point, 2s delay	0.1	0.1	0.3	-0.1	-0.1	-0.5	-0.6	0.3	0.4
Delay disc. indifference point, 24s delay	0.5	0.5	2.3	-0.0	0.3	-0.1	-0.0	0.7	1.5
Delay disc. indifference point, 4s delay	0.1	0.1	0.3	-0.1	0.3	-0.1	-0.1	-0.1	0.5
Delay disc. indifference point, 8s delay	1.8	1.8	4.5	-1.0	1.5	0.9	0.9	1.3	2.1
Indifference point function ln k	0.3	0.5	0.8	-0.7	0.4	0.5	0.5	0.9	0.9
Indifference point function log k	0.3	0.5	0.8	-0.7	0.4	0.5	0.5	0.9	0.9
Patch foraging total patch changes 0 sec	0.1	0.1	0.6	0.8	-0.1	-0.0	0.2	-0.3	-0.3
Patch foraging total patch changes 12 sec	2.3	2.9	3.8	1.3	-1.7	-1.5	-1.9	-1.9	-1.8
Patch foraging total patch changes 18 sec	2.3	2.9	4.2	2.0	-1.7	-1.3	-1.4	-1.6	-2.0
Patch foraging total patch changes 24 sec	2.3	2.8	3.7	1.9	-1.7	-1.5	-1.8	-1.5	-1.6
Patch foraging total patch changes 6 sec	0.2	0.2	0.5	0.5	-0.7	-0.2	-0.1	-0.6	-0.5
Patch foraging time to switch 0 sec	0.0	0.0	0.0	0.2	-0.2	-0.0	-0.1	-0.1	-0.1
Patch foraging water rate 0 sec	0.8	1.3	2.7	0.2	-1.4	-1.6	-1.6	-0.2	-0.3
Patch foraging water rate 12 sec	2.0	3.1	5.2	1.7	-2.3	-1.7	-1.9	-1.3	-1.5
Patch foraging water rate 18 sec	0.2	0.2	0.5	-0.5	-0.1	0.2	0.2	0.7	0.6
Patch foraging water rate 24 sec	1.2	1.7	3.2	0.8	-1.8	-1.8	-1.7	-0.2	-0.3
Patch foraging water rate 6 sec	2.5	3.7	7.5	1.4	-2.7	-2.3	-2.5	-0.6	-0.8
Seeking ratio, delayed vs. immediate footshock	0.0	0.0	0.1	0.1	-0.1	0.0	-0.3	0.0	0.2
Distance traveled before self-admin	0.0	0.0	0.2	-0.2	-0.1	-0.4	-0.2	-0.1	0.0
Distance traveled after self-admin	0.4	0.4	0.8	-0.7	-0.3	-0.1	-0.6	0.9	0.9
Extensor digitorum longus weight	0.0	0.1	0.3	0.5	0.0	-0.2	0.3	-0.2	0.4
Bone: elastic displacement	2.6	3.0	5.9	-1.7	2.4	1.9	1.9	0.6	1.3
Bone: elastic work	1.4	1.8	4.3	-0.9	2.1	1.4	1.7	0.3	0.9
Bone: endosteal estimation	1.2	2.5	5.5	-1.6	0.4	1.0	1.2	2.3	2.1
Bone: endosteal perimeter	0.4	0.9	1.7	-0.4	-1.3	-1.0	-1.0	0.8	0.9
Epididymis fat weight	0.8	1.9	4.4	0.6	-2.1	-1.6	-1.7	-0.2	-0.8
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	-0.6	-0.6	-0.4	-0.4	-0.1	0.0
Delta time in open arm before/after self-admin	1.2	1.1	2.2	-0.5	1.4	1.5	1.3	0.7	0.6
Diff in mean of infusions in LGA sessions	1.0	1.1	2.0	-1.4	1.4	0.9	0.9	0.8	0.6
Delay discount exponential model param	0.9	1.0	3.3	0.8	-0.7	-0.3	-0.0	-1.2	-1.8
Extinction: sum of active levers before priming	0.6	0.6	1.0	-1.0	0.9	0.6	0.6	0.7	0.7
Active lever presses in extinction session 6	0.8	0.8	1.8	-1.3	0.0	0.4	-0.3	1.3	1.1
Bone: final force	0.2	0.3	1.0	-0.4	-0.4	-0.1	-0.5	0.6	1.0
Bone: final moment	0.2	0.3	0.8	-0.4	-0.4	-0.2	-0.6	0.4	0.9
Food consumed during 24 hour testing period	0.7	0.9	1.8	1.1	-1.4	-0.6	-0.5	-0.8	-1.1
Glucose	0.1	0.1	0.2	0.1	-0.4	-0.3	-0.3	-0.3	-0.4
Heart weight	0.9	1.3	2.5	-1.3	1.2	0.6	0.7	1.1	1.6
Delay discount hyperbolic model param	0.7	0.7	2.6	0.6	-0.6	-0.1	0.1	-1.0	-1.6
Intermittent access intake day 1-15 change	3.0	3.0	4.2	1.3	-1.6	-1.9	-1.6	-2.0	-1.9
Intermittent access intake escalation	3.7	3.6	5.3	1.3	-1.7	-2.0	-1.8	-2.3	-2.1
Intermittent access intake escalation 2	0.8	0.8	1.3	0.6	-0.8	-1.0	-0.8	-1.1	-1.0
Intermitt. access day 1 inactive lever presses	0.9	1.0	2.0	-0.7	1.4	1.3	1.4	-0.1	0.1
Intermitt. access day 15 inactive lever presses	1.1	1.2	3.1	-0.6	1.8	1.0	1.5	0.6	0.7
Intermitt. access escalation Index	0.9	0.8	1.6	-1.3	1.1	0.9	0.9	0.4	0.4
Intermittent access day 1 total infusions	1.4	1.6	3.7	1.9	-1.0	-1.5	-0.9	-1.1	-0.9
Intermittent access day 15 total infusions	4.2	4.7	6.9	2.6	-2.0	-2.4	-1.8	-2.2	-1.9
Intermittent access terminal intake (last 3 days)	3.0	3.3	5.0	2.2	-1.6	-2.2	-1.6	-1.7	-1.4
Intermittent access total infusions	2.7	3.0	5.0	2.2	-1.6	-2.2	-1.4	-1.5	-1.3
Intermittent access day 1 locomotion	1.1	1.1	3.8	2.0	-0.8	-0.8	-0.6	-0.8	-0.7
Intermittent access day 15 total locomotion	6.0	6.4	12.6	3.6	-1.9	-2.2	-1.6	-2.9	-2.5
Intermittent access total locomotion	2.6	3.0	7.8	2.8	-1.5	-1.6	-1.2	-1.6	-1.3
Intermittent access standard deviation	4.9	5.2	6.7	2.2	-2.3	-2.6	-2.3	-2.2	-2.0
Left kidney weight	2.1	5.9	7.9	2.5	-2.3	-2.8	-2.3	-2.4	-2.1
Right kidney weight	0.9	2.4	3.9	2.0	-1.6	-1.8	-1.4	-1.3	-1.1
Cocaine induced anxiety	2.6	3.0	3.9	-1.4	1.9	1.8	2.0	1.6	1.6
Post-drug Anxiety	2.0	2.2	4.3	-1.3	2.1	1.5	1.7	1.1	1.0
Baseline Anxiety	0.8	0.9	1.4	0.9	-0.6	-0.9	-0.8	-1.2	-1.1
Tail length	7.7	23.3	44.1	6.6	-4.6	-4.8	-4.1	-4.3	-4.0
Length with tail	10.0	36.5	61.6	7.8	-5.9	-6.3	-5.5	-5.3	-4.9
Length without tail	4.1	9.0	11.9	3.5	-2.8	-3.4	-3.1	-2.7	-2.5
Times rat made contact with spout	6.1	7.0	10.3	1.7	-3.2	-2.8	-3.2	-2.4	-2.3
Lifetime Intake	1.5	1.7	3.3	1.7	-1.2	-1.8	-1.2	-1.0	-0.7
Liver weight, left	0.1	0.1	0.2	-0.5	-0.4	-0.4	-0.4	0.1	-0.1
Liver weight, right	0.3	0.4	0.7	0.7	-0.8	-0.5	-0.8	-0.5	-0.5
Locomotor activity	2.1	3.4	6.0	1.1	-2.3	-2.4	-2.5	-1.0	-0.9
Locomotor testing distance	0.8	1.4	3.2	-0.2	-1.5	-1.6	-1.8	0.1	0.0
Locomotor testing rearing	0.4	0.6	1.4	0.2	-0.7	-1.2	-1.1	-0.4	-0.5
Locomotion in novel chamber	0.0	0.0	0.1	-0.0	0.2	-0.2	-0.0	0.2	0.1
Locomotion in novel chamber post-restriction	0.3	0.4	1.2	1.1	-0.4	-0.5	-0.1	-0.6	-0.5
Fecal boli incidents, locomotor time 1	0.1	0.1	0.5	0.7	-0.2	0.2	0.3	-0.2	-0.3
Change in fecal boli incidents, locomotor task	2.1	2.0	3.6	-1.8	1.2	1.1	0.8	1.9	1.3
Time >=10cm from walls, locomotor time 1	1.6	1.6	2.2	-1.5	1.3	1.1	1.1	1.2	1.4
Bouts of movement, locomotor time 1	0.5	0.5	0.9	-0.6	0.5	0.6	1.0	0.7	0.9
Total resting periods, locomotor time 1	0.5	0.6	1.2	-0.5	0.9	0.6	1.1	0.4	0.7
Rest time, locomotor task time 1	1.5	1.6	4.1	-0.6	2.0	1.1	2.0	-0.0	0.6
Distance moved, locomotor task time 1	2.1	2.3	5.7	0.3	-2.0	-1.4	-2.4	-0.6	-1.2
Vertical activity count, locomotor time 1	2.6	2.7	7.3	0.1	-2.3	-1.7	-2.7	-0.2	-0.7
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.6	-0.3	0.4	-0.1	0.1	-0.8	-0.6
Bouts of movement, locomotor time 2	0.1	0.1	0.4	-0.2	0.3	0.1	0.4	0.2	0.6
Total resting periods, locomotor time 2	0.4	0.4	1.0	-0.6	0.7	0.4	0.6	0.5	1.0
Rest time, locomotor task time 2	2.5	2.9	3.8	-1.8	1.9	1.4	1.7	1.5	1.9
Distance moved, locomotor task time 2	2.2	2.6	3.9	1.2	-1.8	-1.3	-1.6	-1.6	-2.0
Vertical activity count, locomotor time 2	5.4	5.9	9.6	1.9	-3.1	-2.3	-2.9	-2.0	-2.2
Light reinforcement 1	0.1	0.1	0.3	0.0	-0.6	-0.4	-0.2	0.1	-0.4
Light reinforcement 2	0.6	0.8	1.5	-0.4	0.2	1.2	1.1	1.0	0.9
Bone: marrow area	1.1	2.5	5.3	-1.5	0.4	1.0	1.2	2.3	2.1
Bone: maximum diameter	0.5	1.0	2.3	-0.1	-1.5	-1.2	-1.4	0.4	0.4
Bone: maximum force	0.3	0.5	1.9	-0.7	0.1	0.3	0.0	0.9	1.4
Bone: maximum moment	0.3	0.5	1.7	-0.8	0.2	0.2	-0.1	0.7	1.3
Mean time between licks in bursts	0.1	0.1	0.4	-0.4	-0.2	-0.6	-0.5	-0.0	0.2
Mean num. licks in bursts	0.6	0.7	0.9	0.8	-0.6	-0.9	-0.9	-1.0	-0.9
Cd content in liver	0.2	0.3	0.7	-0.3	-0.8	-0.1	-0.2	0.5	0.7
Co content in liver	2.9	3.4	4.8	1.8	-2.2	-1.8	-1.9	-1.6	-1.7
Cu content in liver	1.0	1.2	2.7	1.4	-1.6	-0.5	-0.6	-0.8	-1.1
Fe content in liver	0.2	0.2	0.8	0.1	0.0	0.2	0.2	0.7	0.9
K content in liver	2.5	2.5	5.1	2.2	-1.1	-0.4	-0.4	-1.9	-2.2
Mg content in liver	0.4	0.5	1.2	0.9	-0.5	-0.1	0.0	-0.7	-1.1
Mn content in liver	0.3	0.3	1.0	0.4	-1.0	-0.4	-0.6	-0.2	-0.5
Na content in liver	0.4	0.4	0.7	0.8	-0.8	-0.1	-0.3	-0.6	-0.8
Rb content in liver	0.6	0.7	2.2	1.5	0.1	0.7	0.9	-0.8	-0.5
Se content in liver	0.2	0.3	1.1	-0.4	-0.0	0.6	0.3	1.0	0.2
Sr content in liver	0.1	0.1	0.3	0.2	-0.1	-0.4	-0.5	-0.6	-0.1
Zn content in liver	0.5	0.5	1.3	1.1	-0.3	-0.5	0.1	-0.9	-0.9
Bone: minimum diameter	1.1	2.1	4.7	0.3	-2.0	-1.9	-2.2	0.0	0.2
Time in familiar zone, hab. session 1	0.4	0.4	0.7	-0.7	0.5	0.6	0.5	0.8	0.4
Time in novel zone, hab. session 1	0.3	0.3	0.8	-0.4	0.2	0.5	0.6	0.5	0.9
Total zone transitions, hab. session 1	1.2	1.7	5.1	-0.1	-1.2	-1.7	-2.3	-0.5	-0.9
Total locomotion distance, hab. session 1	1.2	1.7	4.0	-0.1	-1.0	-1.8	-2.0	-0.8	-1.3
Locomotion velocity, hab. session 1	2.2	3.2	7.0	0.1	-1.3	-2.4	-2.6	-1.3	-1.8
Time in familiar zone, hab. session 2	0.0	0.0	0.1	-0.4	0.1	0.1	0.1	0.0	0.2
Time in novel zone, hab. session 2	0.8	0.8	1.2	-0.7	0.8	0.8	0.8	1.1	1.1
Total zone transitions, hab. session 2	0.5	0.6	1.4	-1.2	0.3	-0.6	-1.0	0.7	0.5
Total locomotion distance, hab. session 2	0.5	0.7	2.0	-1.4	0.1	-0.9	-1.1	0.3	-0.1
Locomotion velocity, hab. session 2	0.5	0.7	2.0	-1.4	0.1	-0.9	-1.1	0.2	-0.1
Novel to familiar place preference ratio	0.5	0.6	1.2	1.1	-0.4	-0.2	-0.1	-0.9	-1.1
Novelty place preference	0.4	0.4	1.0	0.9	-0.1	-0.0	0.1	-0.8	-1.0
Time in novel zone, NPP test	0.3	0.3	0.7	0.8	-0.2	-0.0	0.1	-0.6	-0.8
Total zone transitions, NPP test	0.3	0.4	1.3	-0.5	-0.1	-0.6	-1.2	0.5	0.4
Total locomotion distance, NPP test	0.5	0.6	1.9	-0.4	-0.5	-1.1	-1.4	-0.1	-0.5
Locomotion velocity, NPP test	0.3	0.4	1.3	-0.4	-0.3	-1.0	-1.1	-0.1	-0.5
Intraocular pressure	0.2	0.3	0.6	-0.8	0.4	0.6	0.2	0.7	0.6
Delta distance traveled before/after self-admin	0.2	0.2	0.5	-0.1	-0.5	-0.0	-0.7	0.4	0.4
Delta ambulatory time before/after self-admin	0.5	0.5	1.1	-0.7	0.1	0.8	-0.0	1.0	0.9
Parametrial fat weight	1.5	3.0	4.6	-2.0	1.2	1.4	1.2	2.1	2.1
Pavlov. Cond. lever latency	0.4	0.5	1.3	0.0	-0.1	0.3	0.6	1.0	1.1
Pavlov. Cond. magazine entry latency	0.3	0.4	1.8	-1.3	0.1	0.1	-0.3	0.6	0.3
Pavlov. Cond. change in total contacts	0.3	0.3	0.6	-0.7	-0.5	-0.4	-0.8	0.1	-0.4
Pavlov. Cond. index score	0.2	0.2	1.0	-1.0	0.1	-0.2	-0.6	-0.2	-0.3
Pavlov. Cond. latency score	0.2	0.2	0.6	-0.7	0.1	-0.2	-0.6	-0.4	-0.6
Pavlov. Cond. lever contacts	0.8	0.9	1.9	0.2	-0.4	-0.8	-1.1	-1.3	-1.4
Pavlov. Cond. magazine entry number	0.2	0.3	1.3	1.2	-0.3	0.0	0.2	-0.5	-0.3
Pavlov. Cond. intertrial magazine entries	0.8	0.9	1.8	-1.0	0.4	0.5	0.7	1.3	1.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.1	-1.0	0.0	-0.2	-0.6	-0.0	-0.1
Pavlov. Cond. response bias	0.3	0.4	0.9	-0.6	-0.4	-0.6	-0.9	-0.4	-0.7
Pavlov. Cond. lever latency	0.4	0.5	1.4	1.2	-0.5	-0.6	-0.1	-0.9	-0.1
Pavlov. Cond. magazine entry latency	0.5	0.6	1.1	0.1	-0.7	-0.9	-1.1	-0.5	-0.9
Pavlov. Cond. change in total contacts	0.4	0.6	1.8	-0.2	-0.9	-0.9	-1.3	0.3	-0.2
Pavlov. Cond. index score	0.3	0.4	0.9	-0.3	-0.6	-0.6	-0.9	-0.0	-0.7
Pavlov. Cond. latency score	0.2	0.2	0.6	-0.3	-0.5	-0.4	-0.8	0.1	-0.6
Pavlov. Cond. lever contacts	0.4	0.6	2.1	-1.4	0.0	0.4	-0.2	1.1	0.3
Pavlov. Cond. magazine entry number	0.6	0.7	1.7	0.4	1.1	0.9	1.3	-0.1	0.5
Pavlov. Cond. intertrial magazine entries	0.1	0.2	0.4	-0.2	0.6	0.4	0.6	-0.1	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.7	1.4	0.0	-0.8	-0.9	-1.2	-0.3	-0.9
Pavlov. Cond. response bias	0.3	0.4	1.1	-1.0	-0.5	-0.3	-0.8	0.6	-0.1
Time in closed arm before self-admin	0.3	0.3	0.6	0.6	-0.2	-0.7	-0.7	-0.4	-0.5
Time in closed arm after self-admin	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.1	0.2	0.3
Time in open arm before self-admin	0.0	0.0	0.1	-0.3	-0.4	0.1	-0.1	0.0	0.1
Time in open arm after self-admin	0.4	0.4	0.9	-0.4	0.8	1.0	0.7	0.4	0.2
Bone: periosteal estimation	0.3	0.7	2.0	-0.7	-0.2	-0.1	-0.1	1.3	1.4
Bone: periosteal perimeter	0.3	0.4	0.7	-0.4	-0.7	-0.7	-0.8	0.5	0.8
Bone: post-yield work	0.0	0.0	0.1	0.0	-0.0	0.1	0.1	0.4	0.3
Progressive ratio test 1 active lever presses	6.3	6.6	10.1	3.2	-2.9	-2.8	-2.4	-2.0	-1.8
Progressive ratio test 1 breakpoint	5.5	5.7	8.0	2.8	-2.7	-2.7	-2.4	-1.9	-1.7
Progressive ratio test 1 inactive lever presses	0.3	0.3	0.9	1.0	-0.3	-0.5	-0.2	-0.7	-0.4
Progressive ratio test 2 active lever presses	3.9	4.2	5.8	2.4	-1.6	-2.3	-1.7	-2.2	-1.8
Progressive ratio test 2 breakpoint	4.6	5.2	7.3	2.6	-1.9	-2.7	-2.0	-2.4	-2.0
Progressive ratio test 2 inactive lever presses	0.6	0.7	1.5	1.2	-0.1	-0.7	-0.3	-1.2	-0.8
Incentive Sensitization - Responses	4.5	4.5	6.1	2.4	-1.5	-2.3	-1.7	-2.5	-2.3
Incentive Sensitization - Breakpoint	4.1	4.2	5.9	2.3	-1.4	-2.2	-1.6	-2.4	-2.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.3	-0.7	-0.8	-0.7	-1.2	-0.1	-0.3
Progressive ratio	1.3	1.5	2.9	-0.9	1.7	1.0	1.1	1.3	1.2
Food seeking constrained by brief footshock	2.1	2.6	3.9	2.0	-1.6	-1.6	-1.9	-1.4	-1.2
Seeking ratio, punishment vs. effort	1.8	2.2	3.2	1.4	-1.8	-1.3	-1.5	-1.5	-1.3
Retroperitoneal fat weight	0.8	2.5	4.7	1.0	-2.1	-2.2	-2.1	-0.3	-0.8
Reaction time number correct	0.2	0.2	0.7	-0.4	-0.0	0.0	0.1	0.7	0.8
Reaction time mean minus median	0.5	0.6	1.4	-0.5	1.2	0.8	1.0	0.3	0.5
Reaction time mean minus median AUC	0.2	0.3	0.8	-0.4	0.9	0.5	0.6	0.1	0.1
Reaction time num false alarms	0.3	0.5	1.0	-0.1	0.8	1.0	1.0	-0.2	0.1
Reaction time num false alarms AUC	0.7	1.0	1.9	-0.6	1.3	1.3	1.4	0.2	0.5
Reaction time trials correct on left	0.2	0.2	0.7	-0.4	-0.0	0.0	0.1	0.7	0.8
Reaction time trials on left	0.2	0.3	0.8	-0.5	0.1	0.1	0.2	0.8	0.9
Reaction time mean	0.1	0.2	0.5	-0.7	0.1	-0.0	0.1	0.5	0.6
Reaction time mean AUC	0.0	0.1	0.1	-0.3	-0.2	-0.2	-0.1	0.2	0.4
Median of all reaction times	0.1	0.2	0.2	-0.4	-0.4	-0.4	-0.3	0.5	0.4
Reaction time omissions	3.1	4.3	5.8	-2.4	1.7	2.1	2.0	2.0	2.1
Reaction time false alarm rate	0.5	0.8	1.6	-0.4	1.2	1.3	1.2	0.0	0.1
Reaction time premature initiation rate	0.2	0.3	1.1	-1.0	-0.0	-0.0	-0.2	0.6	0.6
Reaction time premature initiations	0.2	0.2	0.4	-0.7	-0.4	-0.3	-0.5	0.4	0.5
Std. dev. reaction times	0.6	0.9	1.7	-0.9	1.3	0.9	1.1	0.5	0.7
Reaction time trials completed	0.2	0.3	0.8	-0.5	0.1	0.1	0.2	0.8	0.9
Reaction time trials AUC	0.2	0.3	0.8	-0.4	-0.1	0.0	0.1	0.8	0.9
Run reversals in cocaine runway, females	0.1	0.1	0.3	0.4	0.0	-0.5	-0.3	-0.1	0.3
Run reversals in cocaine runway, males	0.0	0.0	0.1	-0.1	-0.2	0.0	-0.1	-0.1	-0.1
Latency to leave start box in cocaine runway	0.1	0.1	0.3	-0.4	-0.3	-0.5	-0.3	-0.0	-0.0
Latency to leave start box in cocaine runway, F	0.4	0.5	1.9	-1.4	0.2	0.3	0.1	0.7	0.5
Latency to leave start box in cocaine runway, M	2.4	2.3	4.2	2.1	-1.1	-1.5	-1.0	-1.7	-1.6
Std. dev. time between licks in bursts	1.5	1.8	3.8	-1.9	1.5	0.8	0.8	1.4	1.3
Total sessions with >9 infusions	0.6	0.6	1.2	1.1	-1.0	-1.0	-0.7	-0.3	-0.1
Short access day 1 total inactive lever presses	0.1	0.2	0.4	0.1	0.7	0.1	0.6	-0.2	0.2
Short access day 10 total inactive lever presses	3.1	3.4	7.6	-1.9	2.8	1.9	2.3	0.5	0.5
Short access day 1 total infusions	0.5	0.5	1.3	0.5	-0.9	-1.1	-0.9	-0.3	-0.0
Short access day 10 total infusions	2.2	2.5	3.8	1.9	-1.7	-1.9	-1.5	-1.2	-0.9
Short access total infusions	1.3	1.5	3.2	1.1	-1.3	-1.8	-1.4	-0.8	-0.5
Short access day 1 locomotion	1.7	1.8	2.5	1.4	-1.6	-1.4	-1.4	-1.1	-1.0
Short access day 10 total locomotion	0.1	0.1	0.2	0.4	-0.1	-0.1	-0.4	-0.1	-0.1
Short access total locomotion	2.4	2.5	3.2	1.8	-1.5	-1.6	-1.7	-1.5	-1.3
One hour access (0.3 mA shock)	3.9	4.5	6.9	2.3	-1.7	-2.6	-2.4	-2.0	-1.7
Compulsive drug intake	0.9	0.9	1.9	-1.1	1.4	1.0	0.6	0.5	0.7
One hour access (shock baseline)	4.7	5.4	7.7	2.7	-2.1	-2.8	-2.1	-2.1	-2.1
Social response proportion	0.1	0.1	0.2	0.0	-0.4	-0.4	-0.2	0.2	0.3
Social responses	0.3	0.3	1.1	-0.3	-0.5	-1.0	-0.7	-0.3	-0.0
Social time	0.7	1.0	1.2	0.8	-1.0	-1.1	-1.1	-1.1	-0.9
Soleus weight	0.1	0.4	1.6	-0.6	-0.0	0.2	0.1	0.7	1.3
Bone: stiffness	0.5	0.8	1.9	0.0	-1.4	-0.4	-1.1	0.9	0.9
Tibialis anterior weight	0.4	1.5	3.7	-1.2	0.9	0.8	0.9	1.2	1.9
Time to tail flick, vehicle, before self-admin	6.5	6.7	8.7	2.1	-2.9	-2.8	-2.7	-2.4	-2.6
Time to tail flick, vehicle, after self-admin	1.5	1.6	2.3	-1.5	1.2	1.3	1.2	1.1	1.2
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.3	-0.5	0.1	-0.3	0.4	0.4
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.1	-0.1	-0.2	-0.3	0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	6.3	6.2	7.3	-2.6	2.7	2.6	2.3	2.2	2.4
Delta time to tail flick, test, before/after SA	0.2	0.2	0.4	-0.1	0.5	-0.2	0.2	-0.4	-0.6
Tibia length	5.7	16.1	22.9	3.8	-4.7	-4.8	-4.6	-2.9	-2.8
Ambulatory time before self-admin	0.1	0.1	0.2	0.4	-0.2	-0.4	0.0	-0.5	-0.4
Ambulatory time after self-admin	0.2	0.3	0.6	-0.4	-0.4	-0.1	-0.4	0.7	0.8
Bone: tissue strength	0.1	0.1	0.3	0.2	-0.5	-0.3	-0.5	0.1	0.1
Total heroin consumption	1.3	1.5	3.6	-1.9	0.7	0.9	0.2	1.5	1.3
Bone: trabecular number	0.1	0.1	0.2	0.1	0.1	0.3	0.4	-0.5	-0.2
Bone: trabecular spacing	0.1	0.1	0.5	-0.2	0.7	-0.1	0.1	0.0	-0.1
Bone: trabecular thickness	0.2	0.2	0.5	0.6	-0.3	-0.3	0.0	-0.7	-0.6
Bone: trabecular tissue density	0.0	0.0	0.2	0.1	-0.2	0.0	-0.1	0.4	-0.1
Water consumed over 24 hours	1.4	1.7	3.7	1.5	-1.9	-0.9	-0.8	-1.2	-1.0
Number of responses in last shaping day	1.1	1.1	2.1	1.1	-0.9	-1.3	-1.4	-0.8	-0.6