LOC120093199

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	mRNA stability	LOC120093199	0.15	0.07	0.0e+00	0.21	0.21	0.21	0.21	1.4e-31	7.0e-31	7.7e-31	8.1e-31
2	BLA	mRNA stability	LOC120093199	0.12	0.08	3.3e-06	0.11	0.11	0.12	0.12	1.9e-06	2.0e-06	5.8e-07	1.1e-06
3	IL	mRNA stability	LOC120093199	0.15	0.13	6.8e-03	0.06	0.08	0.05	0.06	1.2e-02	6.8e-03	2.7e-02	1.2e-02
4	PL	mRNA stability	LOC120093199	0.09	0.08	3.2e-08	0.07	0.07	0.07	0.07	7.7e-08	3.3e-08	6.6e-08	7.0e-08
5	Brain	mRNA stability	LOC120093199	0.23	0.11	0.0e+00	0.22	0.22	0.22	0.22	8.5e-20	8.9e-21	3.0e-20	1.7e-20
6	pVTA	mRNA stability	LOC120093199	0.31	0.12	7.8e-16	0.18	0.2	0.19	0.19	1.3e-14	1.5e-15	4.4e-15	4.4e-15

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	4.9	9.1	11.4	3.4	2.8	-3.0	-3.1	-2.8	-3.0
Area under the delay curve	1.5	2.3	3.2	1.8	1.6	-1.5	-1.5	-1.3	-1.4
BMI with tail	0.1	0.4	0.8	-0.9	-0.6	0.7	0.6	0.4	0.6
BMI without tail	0.1	0.7	1.1	-0.6	-0.8	0.9	0.9	1.0	0.7
Body weight	1.4	6.3	6.9	-2.4	-2.5	2.6	2.6	2.6	2.5
Weight adjusted by age	0.0	0.1	0.1	-0.3	-0.2	0.3	0.3	0.4	0.3
Bone surface	1.9	3.8	5.8	2.4	2.0	-1.9	-1.9	-1.7	-1.7
Bone volume	2.4	4.7	7.0	2.6	2.1	-2.1	-2.2	-1.9	-2.1
Breakpoint value in progressive ratio session	0.5	0.9	1.4	1.2	0.8	-0.9	-0.9	-0.7	-1.0
Number of licking bursts	0.1	0.4	1.1	1.0	0.6	-0.6	-0.6	-0.4	-0.6
Context. condit. distance diff. score	0.1	0.2	0.4	-0.4	-0.3	0.4	0.4	0.2	0.6
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	0.4	-0.0
Locomotion distance, session 1	2.1	2.7	2.9	1.7	1.6	-1.7	-1.7	-1.6	-1.6
Locomotion velocity, session 2	0.1	0.1	0.3	0.1	-0.3	0.3	0.4	0.6	0.4
Locomotion distance, session 2	0.0	0.0	0.2	0.4	0.1	-0.2	-0.1	0.1	-0.3
Locomotion velocity, session 3	0.4	0.5	0.9	0.9	0.5	-0.8	-0.7	-0.6	-0.6
Locomotion distance, session 3	1.1	1.2	1.5	1.2	1.0	-1.2	-1.1	-0.9	-1.2
Stereotopy head waving bouts, day 3	0.8	1.0	1.2	0.9	1.1	-1.0	-1.0	-1.0	-0.8
Stereotopy head waving duration, day 3	0.0	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.0	0.1
Locomotion velocity, session 7	0.8	0.9	1.1	1.1	1.0	-1.0	-0.9	-0.8	-0.9
Locomotion distance, session 7	0.0	0.1	0.1	-0.1	-0.2	0.2	0.3	0.3	0.3
Stereotopy head waving bouts, day 7	0.1	0.1	0.1	0.2	0.3	-0.3	-0.3	-0.2	-0.4
Stereotopy head waving duration, day 7	0.6	0.7	1.1	0.8	0.8	-0.9	-0.9	-0.7	-1.0
Locomotion velocity, session 8	0.0	0.0	0.1	0.3	-0.2	-0.0	0.0	0.2	-0.1
Locomotion distance, session 8	0.1	0.1	0.2	0.3	0.5	-0.4	-0.3	-0.4	-0.1
Degree of sensitization distance	1.5	1.6	1.9	-1.4	-1.2	1.3	1.3	1.1	1.4
Degree of sensitization stereotypy	0.0	0.0	0.1	0.0	-0.0	-0.1	-0.0	0.1	-0.2
Conditioned locomotion	1.9	2.2	3.4	1.2	1.6	-1.6	-1.5	-1.8	-1.1
Cocaine response after cond. corrected	2.0	3.1	4.7	2.2	1.6	-1.7	-1.8	-1.4	-1.8
Cocaine response after cond. not corrected	2.6	3.8	4.8	2.2	1.9	-1.9	-2.0	-1.9	-1.8
Cocaine response before conditioning	0.5	0.6	1.2	0.4	0.9	-0.8	-0.7	-1.1	-0.5
Saline control response	1.2	1.7	3.0	1.7	1.0	-1.3	-1.3	-0.8	-1.6
Bone: connectivity density	5.1	8.1	10.5	3.2	2.7	-2.8	-2.9	-2.5	-2.8
Bone: cortical apparent density	0.7	1.1	1.4	1.2	1.0	-1.0	-1.1	-1.0	-1.0
Bone: cortical area	0.7	1.2	1.4	1.1	1.2	-1.1	-1.1	-1.1	-1.0
Bone: cortical porosity	0.9	0.9	1.0	1.0	1.0	-0.9	-1.0	-1.0	-0.9
Bone: cortical porosity	1.2	1.3	1.6	1.3	1.1	-1.1	-1.1	-1.0	-1.1
Bone: cortical thickness	0.0	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.3	-0.2
Bone: cortical thickness	1.2	1.5	2.2	0.8	1.5	-1.2	-1.2	-1.5	-1.0
Bone: cortical tissue density	0.5	0.8	1.1	1.1	0.8	-0.8	-1.0	-0.9	-0.9
Condit. Reinf. active minus inactive responses	0.2	0.2	0.5	0.2	-0.4	0.4	0.4	0.7	0.3
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.3	-0.3	0.3	0.3	0.6	0.1
Condit. Reinf. active responses	0.7	1.0	2.3	1.5	0.9	-0.8	-0.9	-0.6	-0.9
Condit. Reinf. inactive responses	1.6	2.1	2.6	1.6	1.5	-1.3	-1.5	-1.4	-1.4
Incentive salience index mean	0.5	0.6	1.7	1.3	0.6	-0.6	-0.6	-0.2	-0.8
Condit. Reinf. lever presses	1.7	2.5	4.6	2.1	1.5	-1.6	-1.5	-1.0	-1.6
Condit. Reinf. active minus inactive responses	2.1	3.2	4.6	1.7	1.9	-1.7	-1.8	-2.1	-1.4
Condit. Reinf. active-inactive response ratio	0.3	0.5	0.8	0.7	0.7	-0.7	-0.7	-0.9	-0.3
Condit. Reinf. active responses	1.9	2.7	4.4	1.3	1.8	-1.6	-1.7	-2.1	-1.2
Condit. Reinf. inactive responses	1.1	1.6	2.7	0.8	1.4	-1.2	-1.3	-1.6	-1.0
Condit. Reinf. lever presses	1.1	1.7	2.6	0.9	1.5	-1.3	-1.3	-1.6	-1.0
Condit. Reinf. lever reinforcers received	1.7	2.4	3.7	1.3	1.7	-1.5	-1.6	-1.9	-1.2
Conditioned reinforcement - actives	0.0	0.2	0.3	0.5	0.5	-0.4	-0.4	-0.4	-0.2
Conditioned reinforcement - inactives	1.0	2.8	3.0	1.7	1.7	-1.7	-1.7	-1.5	-1.7
Conditioned locomotion	0.2	0.4	0.8	-0.0	-0.6	0.6	0.6	0.9	0.5
Patch foraging indifference point 0 sec	0.1	0.3	0.6	-0.2	-0.6	0.4	0.5	0.8	0.3
Patch foraging indifference point AUC	0.8	1.8	2.7	1.3	1.4	-1.2	-1.3	-1.0	-1.7
Delay disc. indifference point, 0s delay	0.6	0.6	1.1	-1.0	-0.7	0.8	0.8	0.6	0.8
Delay disc. indifference point, 16s delay	1.2	1.7	2.2	1.5	1.3	-1.3	-1.3	-1.1	-1.4
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	0.2	0.0	0.0	-0.0	0.1	-0.1
Delay disc. indifference point, 24s delay	3.5	5.6	6.8	2.6	2.4	-2.4	-2.4	-2.3	-2.0
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.6	0.4	-0.4	-0.4	-0.3	-0.4
Delay disc. indifference point, 8s delay	1.0	1.8	2.7	1.7	1.4	-1.3	-1.3	-1.0	-1.2
Indifference point function ln k	0.0	0.1	0.3	-0.5	-0.3	0.2	0.3	-0.1	0.6
Indifference point function log k	0.0	0.1	0.3	-0.5	-0.3	0.2	0.3	-0.1	0.6
Patch foraging total patch changes 0 sec	0.1	0.2	0.5	-0.2	-0.5	0.4	0.5	0.7	0.3
Patch foraging total patch changes 12 sec	0.6	0.9	1.4	-0.9	-0.9	0.9	1.0	1.2	0.6
Patch foraging total patch changes 18 sec	0.0	0.1	0.2	0.2	-0.1	0.0	0.1	0.5	-0.4
Patch foraging total patch changes 24 sec	0.6	2.1	2.9	-1.1	-1.5	1.5	1.5	1.7	1.4
Patch foraging total patch changes 6 sec	0.0	0.0	0.2	0.1	0.0	0.0	0.1	0.4	-0.3
Patch foraging time to switch 0 sec	0.0	0.2	0.3	0.3	0.4	-0.4	-0.4	-0.5	-0.4
Patch foraging water rate 0 sec	0.0	0.1	0.2	-0.1	-0.3	0.4	0.3	0.4	0.3
Patch foraging water rate 12 sec	0.9	3.5	5.1	-2.1	-1.7	1.9	1.9	1.3	2.3
Patch foraging water rate 18 sec	0.5	1.1	1.9	-1.2	-0.9	1.0	1.0	0.6	1.4
Patch foraging water rate 24 sec	2.1	3.1	3.6	-1.9	-1.7	1.8	1.8	1.6	1.7
Patch foraging water rate 6 sec	1.6	2.4	3.1	-1.5	-1.6	1.5	1.6	1.3	1.8
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	0.6	-0.7	-0.7	0.7	0.7	0.8	0.5
Distance traveled before self-admin	0.0	0.0	0.1	0.1	0.0	0.1	0.0	-0.1	0.3
Distance traveled after self-admin	0.7	1.2	1.7	-0.9	-1.2	1.1	1.0	1.3	0.9
Extensor digitorum longus weight	5.1	20.4	21.3	4.6	4.5	-4.6	-4.6	-4.4	-4.5
Bone: elastic displacement	0.6	0.7	1.2	0.5	1.0	-0.7	-0.9	-1.1	-0.7
Bone: elastic work	0.9	1.2	1.6	0.8	1.2	-1.0	-1.1	-1.3	-0.9
Bone: endosteal estimation	0.3	0.7	1.0	1.0	0.9	-0.9	-0.7	-0.7	-0.5
Bone: endosteal perimeter	0.1	0.4	0.8	0.9	0.6	-0.6	-0.5	-0.4	-0.4
Epididymis fat weight	10.4	52.7	55.4	-7.1	-7.4	7.4	7.4	7.3	7.0
Delta time in closed arm before/after self-admin	0.0	0.0	0.0	0.0	0.0	0.1	0.1	-0.0	0.1
Delta time in open arm before/after self-admin	0.9	1.0	2.2	0.9	0.8	-1.0	-1.0	-0.7	-1.5
Diff in mean of infusions in LGA sessions	0.0	0.1	0.3	0.4	0.0	-0.2	-0.2	0.1	-0.5
Delay discount exponential model param	2.4	3.2	4.6	-2.1	-1.9	1.8	1.8	1.6	1.7
Extinction: sum of active levers before priming	0.8	1.2	1.6	1.3	1.1	-1.1	-1.1	-1.0	-1.1
Active lever presses in extinction session 6	0.0	0.0	0.0	0.1	-0.0	0.0	-0.0	0.1	-0.1
Bone: final force	0.2	0.3	0.5	0.7	0.6	-0.6	-0.5	-0.4	-0.6
Bone: final moment	0.2	0.3	0.5	0.7	0.6	-0.6	-0.5	-0.4	-0.6
Food consumed during 24 hour testing period	0.1	0.1	0.3	0.1	0.6	-0.3	-0.3	-0.4	-0.3
Glucose	0.5	0.7	1.1	-0.4	-1.1	0.9	0.8	1.0	0.7
Heart weight	2.8	4.6	4.9	-2.2	-2.1	2.1	2.2	2.0	2.1
Delay discount hyperbolic model param	1.8	2.3	3.4	-1.8	-1.6	1.5	1.5	1.3	1.4
Intermittent access intake day 1-15 change	0.1	0.7	1.4	-1.2	-0.6	0.7	0.8	0.3	1.2
Intermittent access intake escalation	0.2	1.0	1.8	-1.3	-0.8	0.9	0.9	0.5	1.4
Intermittent access intake escalation 2	0.6	1.1	1.9	-1.3	-0.8	1.0	1.0	0.5	1.4
Intermitt. access day 1 inactive lever presses	0.1	0.9	1.8	1.3	0.8	-0.9	-0.9	-0.4	-1.1
Intermitt. access day 15 inactive lever presses	0.7	3.7	4.5	2.1	2.1	-1.9	-1.9	-1.6	-2.0
Intermitt. access escalation Index	0.2	0.5	0.8	-0.9	-0.7	0.7	0.7	0.9	0.2
Intermittent access day 1 total infusions	1.6	4.6	6.0	2.4	2.1	-2.1	-2.1	-1.7	-2.4
Intermittent access day 15 total infusions	0.3	0.8	1.0	0.9	1.0	-0.9	-0.9	-0.9	-0.8
Intermittent access terminal intake (last 3 days)	1.0	1.7	2.2	1.5	1.3	-1.3	-1.3	-1.2	-1.2
Intermittent access total infusions	1.4	1.6	2.2	1.5	1.3	-1.2	-1.3	-1.1	-1.2
Intermittent access day 1 locomotion	1.4	2.7	3.4	1.8	1.6	-1.6	-1.6	-1.3	-1.9
Intermittent access day 15 total locomotion	0.0	0.0	0.1	0.3	0.1	-0.0	-0.1	0.1	0.0
Intermittent access total locomotion	0.1	0.1	0.3	0.6	0.3	-0.2	-0.3	-0.1	-0.4
Intermittent access standard deviation	0.1	0.4	0.7	0.6	0.8	-0.6	-0.6	-0.6	-0.6
Left kidney weight	0.0	0.1	0.2	0.4	0.3	-0.1	-0.2	-0.2	0.1
Right kidney weight	0.0	0.2	0.5	-0.3	-0.3	0.5	0.5	0.5	0.7
Cocaine induced anxiety	0.1	0.2	0.4	0.5	0.2	-0.4	-0.4	-0.2	-0.6
Post-drug Anxiety	1.0	1.2	1.8	-0.7	-1.3	1.1	1.1	1.3	0.8
Baseline Anxiety	1.3	2.1	2.8	-1.1	-1.6	1.5	1.5	1.7	1.4
Tail length	0.4	2.0	2.7	-0.9	-1.4	1.4	1.5	1.6	1.5
Length with tail	1.8	8.1	9.0	-2.5	-2.8	2.9	2.9	3.0	3.0
Length without tail	0.6	3.0	3.5	-1.9	-1.7	1.7	1.7	1.5	1.9
Times rat made contact with spout	3.1	3.6	5.1	2.3	1.8	-2.0	-1.9	-1.5	-1.9
Lifetime Intake	1.1	1.4	2.0	1.4	1.2	-1.1	-1.2	-0.9	-1.3
Liver weight, left	3.1	5.3	7.3	-2.1	-2.4	2.3	2.4	2.7	2.0
Liver weight, right	8.5	14.8	17.4	-3.5	-4.0	4.0	3.9	4.2	3.5
Locomotor activity	0.2	0.3	0.7	0.8	0.5	-0.4	-0.4	-0.1	-0.6
Locomotor testing distance	0.9	2.3	3.6	1.9	1.5	-1.4	-1.5	-1.1	-1.6
Locomotor testing rearing	0.4	1.3	1.8	1.3	1.1	-1.0	-1.2	-0.9	-1.3
Locomotion in novel chamber	0.8	1.0	1.1	-1.1	-1.0	1.1	1.0	1.0	0.9
Locomotion in novel chamber post-restriction	1.0	3.0	3.6	-1.5	-1.9	1.8	1.7	1.8	1.6
Fecal boli incidents, locomotor time 1	0.3	0.7	0.8	0.9	0.6	-0.9	-0.8	-0.8	-0.8
Change in fecal boli incidents, locomotor task	3.6	3.8	4.2	-2.0	-2.0	2.0	1.9	2.0	1.7
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	0.0	0.2	-0.1	-0.3	-0.3	-0.1
Bouts of movement, locomotor time 1	2.7	3.5	4.4	1.7	2.0	-2.0	-1.9	-2.1	-1.6
Total resting periods, locomotor time 1	2.9	3.3	4.4	1.6	1.9	-2.0	-1.8	-2.1	-1.5
Rest time, locomotor task time 1	0.1	0.2	0.2	-0.2	-0.5	0.3	0.4	0.4	0.5
Distance moved, locomotor task time 1	0.2	0.4	0.6	-0.6	-0.7	0.7	0.7	0.8	0.4
Vertical activity count, locomotor time 1	0.1	0.4	0.5	-0.7	-0.5	0.7	0.6	0.5	0.7
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.0	0.1	0.0	0.1	-0.1	-0.1	0.0
Bouts of movement, locomotor time 2	0.1	0.2	0.6	-0.3	-0.3	0.4	0.4	0.2	0.8
Total resting periods, locomotor time 2	0.0	0.1	0.3	-0.1	-0.1	0.2	0.2	-0.0	0.6
Rest time, locomotor task time 2	1.0	1.8	1.9	1.4	1.2	-1.4	-1.4	-1.3	-1.2
Distance moved, locomotor task time 2	0.8	1.1	1.2	-1.0	-1.0	1.1	1.1	1.1	0.8
Vertical activity count, locomotor time 2	0.8	1.8	2.3	-1.4	-1.2	1.4	1.4	1.2	1.5
Light reinforcement 1	1.9	8.5	9.9	2.7	2.9	-3.0	-3.0	-2.8	-3.2
Light reinforcement 2	1.8	4.0	4.4	1.8	2.0	-2.1	-2.0	-2.0	-2.0
Bone: marrow area	0.3	0.7	1.0	1.0	0.9	-0.9	-0.7	-0.8	-0.5
Bone: maximum diameter	1.3	2.5	3.1	1.8	1.7	-1.6	-1.6	-1.5	-1.4
Bone: maximum force	0.1	0.3	0.3	0.5	0.6	-0.5	-0.5	-0.5	-0.6
Bone: maximum moment	0.2	0.3	0.4	0.6	0.6	-0.6	-0.6	-0.5	-0.6
Mean time between licks in bursts	0.7	4.3	4.9	-2.1	-2.1	2.1	2.1	1.9	2.2
Mean num. licks in bursts	0.1	0.1	0.2	0.2	0.4	-0.4	-0.4	-0.3	-0.4
Cd content in liver	0.1	0.1	0.2	0.2	0.4	-0.3	-0.3	-0.3	-0.4
Co content in liver	8.5	9.9	10.3	3.1	3.2	-3.2	-3.2	-3.1	-3.2
Cu content in liver	0.6	0.7	1.7	1.3	0.6	-0.8	-0.8	-0.3	-1.0
Fe content in liver	0.7	0.9	2.0	1.4	1.0	-0.8	-0.9	-0.5	-0.9
K content in liver	0.1	0.1	0.1	0.4	0.2	-0.3	-0.1	-0.1	0.2
Mg content in liver	0.6	0.6	1.5	1.2	0.6	-0.9	-0.6	-0.3	-0.7
Mn content in liver	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.0	-0.1	0.1
Na content in liver	0.2	0.2	0.9	0.9	0.4	-0.4	-0.3	-0.2	-0.1
Rb content in liver	0.1	0.2	0.3	0.6	0.4	-0.5	-0.3	-0.1	-0.4
Se content in liver	0.2	0.2	0.5	-0.2	-0.5	0.5	0.5	0.7	0.3
Sr content in liver	0.3	0.3	0.6	-0.5	-0.5	0.5	0.6	0.4	0.8
Zn content in liver	0.2	0.2	0.7	0.1	-0.6	0.5	0.4	0.8	0.1
Bone: minimum diameter	0.0	0.0	0.1	0.1	-0.0	-0.0	0.1	0.3	-0.0
Time in familiar zone, hab. session 1	0.5	0.5	0.8	-0.8	-0.9	0.6	0.7	0.9	0.5
Time in novel zone, hab. session 1	0.5	0.6	0.7	-0.7	-0.8	0.8	0.8	0.7	0.7
Total zone transitions, hab. session 1	0.1	0.2	0.2	0.5	0.4	-0.4	-0.4	-0.5	-0.4
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	-0.3	0.0
Locomotion velocity, hab. session 1	0.6	0.9	1.4	0.8	1.1	-0.9	-0.9	-1.2	-0.7
Time in familiar zone, hab. session 2	0.0	0.0	0.1	0.1	0.1	-0.2	-0.1	0.2	-0.3
Time in novel zone, hab. session 2	0.5	0.5	0.7	-0.7	-0.8	0.8	0.6	0.4	0.8
Total zone transitions, hab. session 2	0.1	0.2	0.2	0.4	0.5	-0.5	-0.4	-0.4	-0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.0	0.4	-0.4	-0.3	-0.5	-0.1
Locomotion velocity, hab. session 2	0.3	0.3	0.5	0.3	0.7	-0.7	-0.6	-0.7	-0.4
Novel to familiar place preference ratio	0.5	0.7	1.1	-0.9	-0.7	0.9	0.8	0.4	1.0
Novelty place preference	0.9	1.2	1.7	-1.2	-1.0	1.2	1.1	0.7	1.3
Time in novel zone, NPP test	1.2	1.4	1.9	-1.2	-1.2	1.3	1.2	0.9	1.4
Total zone transitions, NPP test	1.4	2.1	2.4	1.4	1.5	-1.5	-1.5	-1.4	-1.4
Total locomotion distance, NPP test	1.2	1.7	2.4	1.0	1.4	-1.3	-1.3	-1.5	-1.0
Locomotion velocity, NPP test	2.6	3.8	4.7	1.6	2.1	-2.0	-2.0	-2.2	-1.7
Intraocular pressure	2.4	3.9	4.7	-1.7	-2.0	2.0	2.0	2.2	1.9
Delta distance traveled before/after self-admin	1.7	1.9	2.6	-1.3	-1.5	1.4	1.4	1.6	1.0
Delta ambulatory time before/after self-admin	0.1	0.2	0.4	-0.5	-0.5	0.5	0.4	0.6	0.1
Parametrial fat weight	8.3	19.6	22.6	-4.5	-4.6	4.5	4.5	4.8	3.7
Pavlov. Cond. lever latency	2.2	2.8	4.7	-2.2	-1.7	1.7	1.6	1.2	1.6
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	0.7	0.3	-0.4	-0.3	-0.1	-0.3
Pavlov. Cond. change in total contacts	0.2	0.2	1.0	1.0	0.4	-0.3	-0.3	0.1	-0.3
Pavlov. Cond. index score	0.9	1.1	2.2	1.5	1.0	-1.0	-0.9	-0.7	-0.9
Pavlov. Cond. latency score	0.8	1.0	2.1	1.5	1.0	-1.0	-0.9	-0.6	-0.8
Pavlov. Cond. lever contacts	1.5	1.8	3.5	1.9	1.3	-1.3	-1.2	-0.9	-1.2
Pavlov. Cond. magazine entry number	0.3	0.4	0.8	-0.9	-0.6	0.6	0.5	0.5	0.5
Pavlov. Cond. intertrial magazine entries	1.7	2.1	2.3	1.4	1.4	-1.4	-1.5	-1.4	-1.5
Pavlov. Cond. lever-magazine prob. diff.	1.7	2.1	3.6	1.9	1.5	-1.4	-1.4	-1.1	-1.3
Pavlov. Cond. response bias	1.2	1.5	2.7	1.6	1.2	-1.2	-1.1	-0.9	-1.0
Pavlov. Cond. lever latency	1.0	1.4	1.7	-1.1	-1.2	1.2	1.2	1.3	1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	0.2	-0.3	-0.3	-0.3	-0.3
Pavlov. Cond. change in total contacts	0.2	0.5	0.8	0.6	0.9	-0.7	-0.7	-0.9	-0.4
Pavlov. Cond. index score	0.4	0.6	0.9	0.7	0.8	-0.8	-0.8	-1.0	-0.5
Pavlov. Cond. latency score	0.3	0.6	0.8	0.7	0.8	-0.7	-0.8	-0.9	-0.5
Pavlov. Cond. lever contacts	0.6	0.8	1.2	0.8	1.0	-0.9	-0.9	-1.1	-0.7
Pavlov. Cond. magazine entry number	0.0	0.1	0.1	-0.2	-0.3	0.2	0.2	0.3	0.2
Pavlov. Cond. intertrial magazine entries	1.6	3.6	4.7	-2.2	-1.9	1.9	1.9	1.7	1.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.3	0.6	-0.5	-0.5	-0.7	-0.2
Pavlov. Cond. response bias	1.1	1.5	2.2	1.0	1.3	-1.3	-1.2	-1.5	-1.0
Time in closed arm before self-admin	0.8	1.5	2.1	-1.5	-1.2	1.3	1.2	1.0	1.1
Time in closed arm after self-admin	1.6	1.8	2.0	-1.4	-1.4	1.4	1.3	1.3	1.2
Time in open arm before self-admin	0.1	0.2	0.3	0.6	0.4	-0.5	-0.4	-0.4	-0.2
Time in open arm after self-admin	2.6	2.9	3.7	1.8	1.6	-1.7	-1.7	-1.4	-1.9
Bone: periosteal estimation	0.7	1.7	2.2	1.5	1.5	-1.4	-1.3	-1.3	-1.1
Bone: periosteal perimeter	0.3	0.7	0.8	0.9	0.9	-0.9	-0.8	-0.8	-0.6
Bone: post-yield work	0.6	0.9	1.3	1.1	1.0	-1.0	-1.0	-0.9	-0.9
Progressive ratio test 1 active lever presses	0.6	1.1	1.7	1.3	1.0	-1.0	-1.0	-0.8	-1.1
Progressive ratio test 1 breakpoint	0.7	1.2	1.7	1.3	1.0	-1.1	-1.1	-0.9	-1.1
Progressive ratio test 1 inactive lever presses	0.8	2.1	2.9	1.7	1.4	-1.3	-1.4	-1.0	-1.7
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	0.4	-0.1	-0.0	-0.0	0.0	0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.1	0.3	-0.1	0.0	0.0	0.1	0.3
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.4	0.7	0.4	-0.4	-0.4	-0.3	-0.3
Incentive Sensitization - Responses	0.0	0.1	0.3	-0.2	-0.2	0.1	0.1	-0.2	0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.4	-0.3	-0.3	0.2	0.2	-0.0	0.7
Sum of active levers in priming session hrs 5-6	1.2	1.2	1.4	1.2	1.1	-1.1	-1.1	-1.1	-0.9
Progressive ratio	0.5	1.5	1.7	-1.2	-1.2	1.3	1.3	1.3	1.2
Food seeking constrained by brief footshock	1.7	2.2	2.4	1.5	1.5	-1.4	-1.5	-1.4	-1.5
Seeking ratio, punishment vs. effort	0.9	1.9	2.1	1.3	1.4	-1.4	-1.4	-1.4	-1.4
Retroperitoneal fat weight	19.0	85.2	92.5	-9.1	-9.6	9.4	9.3	9.5	8.4
Reaction time number correct	0.2	0.8	1.1	1.1	1.0	-0.8	-0.9	-1.1	-0.5
Reaction time mean minus median	0.0	0.1	0.2	0.4	0.2	-0.3	-0.4	-0.2	-0.5
Reaction time mean minus median AUC	0.0	0.0	0.1	0.2	-0.1	-0.0	-0.1	-0.0	-0.2
Reaction time num false alarms	0.2	0.4	0.5	0.3	0.7	-0.7	-0.6	-0.6	-0.7
Reaction time num false alarms AUC	0.3	0.8	1.0	0.6	1.0	-1.0	-0.9	-0.9	-0.9
Reaction time trials correct on left	0.2	0.8	1.1	1.1	1.0	-0.8	-0.9	-1.1	-0.5
Reaction time trials on left	0.3	0.9	1.2	1.1	1.0	-0.9	-0.9	-1.1	-0.5
Reaction time mean	0.2	0.4	1.1	-0.2	-0.8	0.7	0.6	1.1	0.2
Reaction time mean AUC	0.1	0.3	0.9	-0.0	-0.7	0.5	0.4	0.9	0.0
Median of all reaction times	0.3	0.5	1.4	-0.2	-0.9	0.7	0.6	1.2	0.2
Reaction time omissions	0.1	0.1	0.3	0.2	0.2	-0.4	-0.4	-0.3	-0.6
Reaction time false alarm rate	0.1	0.1	0.2	-0.1	0.3	-0.4	-0.3	-0.2	-0.5
Reaction time premature initiation rate	0.1	0.2	0.2	-0.4	-0.5	0.4	0.4	0.5	0.4
Reaction time premature initiations	0.0	0.0	0.0	0.2	0.1	-0.1	-0.1	-0.2	0.1
Std. dev. reaction times	0.0	0.1	0.3	-0.2	-0.5	0.4	0.3	0.5	0.1
Reaction time trials completed	0.3	0.9	1.2	1.1	1.0	-0.9	-0.9	-1.1	-0.5
Reaction time trials AUC	0.3	1.2	1.7	1.3	1.1	-1.0	-1.1	-1.2	-0.7
Run reversals in cocaine runway, females	0.1	0.1	0.2	-0.5	-0.1	0.2	0.2	-0.2	0.5
Run reversals in cocaine runway, males	0.4	0.4	0.7	0.4	0.8	-0.6	-0.6	-0.8	-0.4
Latency to leave start box in cocaine runway	0.3	0.4	0.5	0.6	0.5	-0.6	-0.6	-0.6	-0.7
Latency to leave start box in cocaine runway, F	0.3	0.4	0.6	0.7	0.5	-0.7	-0.6	-0.6	-0.7
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	-0.2	0.3	0.2	0.3	0.1
Std. dev. time between licks in bursts	0.0	0.0	0.1	0.1	-0.1	0.2	0.1	0.2	-0.0
Total sessions with >9 infusions	0.1	0.2	0.5	0.6	0.3	-0.2	-0.3	0.1	-0.7
Short access day 1 total inactive lever presses	3.5	6.9	8.3	2.9	2.6	-2.5	-2.7	-2.3	-2.8
Short access day 10 total inactive lever presses	0.4	2.6	3.1	1.5	1.7	-1.6	-1.6	-1.6	-1.6
Short access day 1 total infusions	0.8	1.5	2.7	1.4	1.2	-1.1	-1.2	-0.7	-1.6
Short access day 10 total infusions	1.3	2.2	3.2	1.8	1.4	-1.4	-1.5	-1.2	-1.6
Short access total infusions	0.2	0.3	0.5	0.7	0.4	-0.4	-0.4	-0.0	-0.7
Short access day 1 locomotion	1.1	1.8	2.4	1.5	1.3	-1.3	-1.3	-1.0	-1.5
Short access day 10 total locomotion	0.7	2.7	3.6	1.9	1.6	-1.6	-1.6	-1.4	-1.7
Short access total locomotion	0.0	0.0	0.1	0.3	0.2	-0.1	-0.1	0.1	-0.3
One hour access (0.3 mA shock)	0.2	0.3	0.5	0.7	0.4	-0.5	-0.5	-0.3	-0.4
Compulsive drug intake	0.3	0.5	0.9	-1.0	-0.7	0.7	0.6	0.6	0.6
One hour access (shock baseline)	0.5	1.3	2.1	1.4	1.1	-1.2	-1.2	-1.0	-1.0
Social response proportion	0.4	0.5	0.7	-0.9	-0.6	0.7	0.7	0.8	0.4
Social responses	0.0	0.0	0.1	-0.2	0.0	0.1	0.0	0.3	-0.2
Social time	0.4	0.7	1.0	-0.9	-0.7	0.9	0.8	1.0	0.5
Soleus weight	6.3	18.6	19.2	4.3	4.3	-4.4	-4.4	-4.3	-4.3
Bone: stiffness	0.0	0.0	0.0	0.1	0.2	-0.1	-0.1	-0.0	-0.1
Tibialis anterior weight	4.8	16.5	17.1	3.9	4.1	-4.1	-4.1	-4.1	-4.1
Time to tail flick, vehicle, before self-admin	0.8	0.9	1.0	-1.0	-1.0	1.0	1.0	0.8	0.9
Time to tail flick, vehicle, after self-admin	1.2	2.4	2.9	-1.4	-1.6	1.6	1.6	1.7	1.5
Time to tail flick, test, before self-admin	0.1	0.1	0.2	0.1	0.3	-0.3	-0.3	-0.3	-0.5
Time to tail flick, test, after self-admin	0.1	0.1	0.2	0.2	0.2	-0.3	-0.3	-0.4	-0.0
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.0	-0.0	0.1	0.2	0.2	0.3
Delta time to tail flick, test, before/after SA	0.8	1.0	1.5	1.0	1.1	-1.1	-1.0	-1.2	-0.6
Tibia length	2.6	7.3	10.2	-2.1	-2.7	2.8	2.7	3.2	2.5
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	0.2	-0.2	-0.1	-0.2	0.2
Ambulatory time after self-admin	0.4	0.7	1.0	-0.7	-0.9	0.9	0.8	1.0	0.7
Bone: tissue strength	0.3	0.3	0.5	-0.6	-0.7	0.6	0.6	0.6	0.4
Total heroin consumption	3.4	4.0	4.3	1.9	2.0	-2.1	-2.1	-2.0	-2.0
Bone: trabecular number	3.9	7.4	9.5	3.1	2.5	-2.7	-2.7	-2.4	-2.8
Bone: trabecular spacing	1.5	2.2	2.7	-1.7	-1.4	1.4	1.5	1.5	1.3
Bone: trabecular thickness	0.6	0.8	0.9	0.9	0.7	-1.0	-0.9	-0.9	-1.0
Bone: trabecular tissue density	0.1	0.2	0.2	0.5	0.5	-0.4	-0.4	-0.5	-0.2
Water consumed over 24 hours	0.3	0.6	0.9	1.0	0.8	-0.8	-0.7	-0.6	-0.6
Number of responses in last shaping day	0.2	0.2	0.4	-0.0	-0.3	0.5	0.5	0.6	0.5