Hub : Genes

LOC108353253

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression LOC108353253 0.48 0.16 4.1e-06 0.11 0.26 0.25 0.25 1.2e-03 5.7e-07 1.5e-06 1.2e-06
2 Adipose mRNA stability LOC108353253 0.53 0.14 0.0e+00 0.51 0.56 0.58 0.59 6.2e-66 9.3e-76 1.2e-79 7.6e-81
3 Eye gene expression LOC108353253 0.76 0.11 1.4e-05 0.18 0.14 0.19 0.2 1.2e-03 3.4e-03 7.1e-04 4.4e-04
4 PL gene expression LOC108353253 0.59 0.11 0.0e+00 0.4 0.42 0.43 0.43 4.1e-47 3.7e-50 1.2e-51 6.2e-51
5 Liver mRNA stability LOC108353253 0.33 0.12 0.0e+00 0.22 0.19 0.3 0.28 7.8e-24 1.9e-20 1.4e-33 4.5e-31
6 pVTA gene expression LOC108353253 0.55 0.1 0.0e+00 0.37 0.43 0.43 0.43 1.4e-31 1.7e-37 7.0e-38 2.0e-37
7 NAcc gene expression LOC108353253 0.4 0.09 0.0e+00 0.37 0.37 0.37 0.37 2.4e-58 2.3e-59 1.5e-59 1.1e-59
8 IL gene expression LOC108353253 0.33 0.15 4.5e-04 0.14 0.14 0.14 0.17 3.2e-04 3.4e-04 3.0e-04 8.4e-05
9 RMTg gene expression LOC108353253 0.47 0.12 1.6e-08 0.33 0.3 0.34 0.39 1.6e-09 8.3e-09 5.6e-10 2.8e-11
10 IC gene expression LOC108353253 0.6 0.11 0.0e+00 0.32 0.44 0.4 0.43 6.3e-14 5.6e-20 8.5e-18 9.1e-20
11 Adipose gene expression LOC108353253 0.8 0.08 0.0e+00 0.62 0.67 0.68 0.67 1.0e-86 5.0e-100 7.0e-103 4.1e-101
12 Brain gene expression LOC108353253 0.52 0.12 0.0e+00 0.36 0.39 0.39 0.39 1.2e-34 3.4e-38 1.8e-38 1.6e-38
13 BLA gene expression LOC108353253 0.5 0.11 0.0e+00 0.25 0.29 0.21 0.26 1.5e-13 8.3e-16 3.0e-11 3.4e-14
14 Liver gene expression LOC108353253 0.67 0.1 0.0e+00 0.53 0.29 0.61 0.31 7.6e-69 8.1e-33 1.6e-85 2.0e-35
15 LHb gene expression LOC108353253 0.35 0.13 2.4e-04 0.2 0.04 0.14 0.2 1.5e-05 3.6e-02 2.9e-04 1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.34.26.7-2.0-2.2-2.12.22.22.1-2.1-1.7-1.7-2.62.1-2.1-2.02.11.1
Area under the delay curve0.20.41.10.60.61.1-0.7-0.7-0.50.50.30.50.7-0.70.4-0.1-0.4-0.5
BMI with tail0.30.92.6-1.60.7-0.81.3-0.50.3-0.6-1.3-1.2-0.5-0.9-0.6-1.3-0.71.0
BMI without tail0.31.68.1-0.52.20.10.6-1.6-0.20.3-1.0-1.00.6-2.8-0.1-0.6-2.20.8
Body weight1.25.018.41.54.32.4-1.2-3.4-2.32.10.30.31.3-3.41.50.5-3.2-0.2
Weight adjusted by age1.23.67.61.42.81.5-1.4-2.5-2.02.11.00.82.2-2.41.61.7-2.5-1.1
Bone surface0.10.31.10.50.30.6-0.3-0.4-0.40.60.60.7-0.00.10.50.2-0.2-1.0
Bone volume0.20.30.9-0.6-0.3-0.40.80.40.6-0.5-0.5-0.5-1.00.4-0.6-0.90.3-0.3
Breakpoint value in progressive ratio session0.00.00.20.3-0.40.0-0.20.20.2-0.00.20.20.10.20.00.20.20.1
Number of licking bursts0.72.35.21.50.01.4-1.7-0.7-1.31.52.32.31.60.21.81.5-0.3-1.9
Context. condit. distance diff. score1.41.76.71.2-1.30.6-1.00.4-0.90.11.51.50.02.10.91.41.0-2.6
Locomotion velocity, session 10.10.10.60.8-0.10.5-0.60.0-0.30.10.40.30.40.10.20.60.20.1
Locomotion distance, session 11.31.73.4-1.2-1.8-1.21.21.51.3-1.4-0.9-0.9-1.31.5-1.2-1.41.60.8
Locomotion velocity, session 20.10.10.30.6-0.50.4-0.40.3-0.1-0.10.50.20.10.60.20.10.5-0.3
Locomotion distance, session 20.91.23.4-0.7-1.8-0.70.61.40.7-1.2-0.4-0.6-1.11.8-0.7-0.91.70.8
Locomotion velocity, session 30.30.40.8-0.70.0-0.60.70.30.7-0.7-0.9-0.9-0.4-0.5-0.9-0.7-0.10.3
Locomotion distance, session 31.51.72.8-0.9-1.6-1.11.01.71.3-1.6-0.9-1.2-1.51.6-1.4-1.01.60.3
Stereotopy head waving bouts, day 32.63.14.61.91.92.1-1.8-1.8-1.91.81.61.71.8-1.41.71.6-1.5-1.8
Stereotopy head waving duration, day 32.43.04.51.62.11.8-1.6-1.9-1.61.81.31.52.0-2.01.61.6-1.9-1.5
Locomotion velocity, session 73.23.510.3-1.2-2.7-1.51.52.51.5-1.8-0.6-0.7-2.43.2-1.3-1.22.80.6
Locomotion distance, session 73.84.911.2-1.4-3.2-1.71.63.02.0-2.3-1.1-1.0-2.53.3-1.8-1.73.30.8
Stereotopy head waving bouts, day 70.60.71.51.11.21.2-0.7-0.7-0.30.90.50.70.6-1.20.50.0-0.7-0.9
Stereotopy head waving duration, day 70.60.82.01.01.41.2-0.7-0.9-0.50.90.40.70.6-1.30.60.1-0.9-0.8
Locomotion velocity, session 84.04.98.42.90.82.6-2.7-1.3-2.32.02.92.71.90.12.42.4-0.6-2.9
Locomotion distance, session 81.21.79.60.5-2.20.2-0.31.2-0.4-0.70.90.7-0.93.10.20.42.1-1.6
Degree of sensitization distance0.80.92.50.9-0.00.9-1.0-0.5-0.91.01.31.60.90.41.21.1-0.1-1.0
Degree of sensitization stereotypy0.10.10.30.40.20.5-0.10.00.30.20.10.3-0.1-0.4-0.0-0.50.0-0.5
Conditioned locomotion0.70.91.40.71.01.0-0.8-1.1-1.21.00.80.90.8-0.51.10.8-0.9-1.0
Cocaine response after cond. corrected0.30.42.5-0.5-1.2-0.30.30.6-0.0-0.40.30.3-0.41.60.1-0.21.0-0.5
Cocaine response after cond. not corrected0.71.01.91.00.51.1-1.0-0.9-1.20.91.31.21.0-0.01.21.0-0.5-1.4
Cocaine response before conditioning4.65.510.92.53.32.5-2.2-2.8-2.12.31.21.22.5-3.31.81.9-3.0-1.2
Saline control response1.31.85.2-1.01.6-0.71.0-0.60.8-0.5-2.0-2.0-0.2-2.3-1.3-0.9-1.41.7
Bone: connectivity density1.22.03.9-1.4-1.7-1.61.41.61.3-1.2-0.8-0.8-1.92.0-1.1-0.91.60.8
Bone: cortical apparent density0.91.42.7-1.6-0.1-1.21.50.51.0-1.2-1.6-1.6-0.9-0.2-1.3-1.30.11.3
Bone: cortical area0.20.20.80.60.70.9-0.4-0.7-0.60.40.20.20.4-0.60.3-0.1-0.5-0.2
Bone: cortical porosity0.60.72.50.90.90.8-0.7-0.7-0.10.70.50.51.1-1.60.20.2-1.1-1.0
Bone: cortical porosity1.31.42.21.41.11.3-1.3-1.0-0.61.21.21.11.4-1.50.90.8-1.2-1.3
Bone: cortical thickness1.22.16.0-1.6-0.4-0.91.70.81.4-1.4-1.9-1.9-1.3-0.2-1.7-2.40.61.4
Bone: cortical thickness1.92.44.4-2.0-0.6-1.61.90.81.6-1.4-2.1-1.8-1.3-0.2-1.8-2.00.41.8
Bone: cortical tissue density0.71.12.3-1.5-0.0-1.11.30.40.9-1.1-1.5-1.4-0.8-0.2-1.2-1.10.01.2
Condit. Reinf. active minus inactive responses0.20.20.7-0.0-0.8-0.60.30.60.7-0.3-0.3-0.3-0.40.2-0.5-0.10.40.3
Condit. Reinf. active-inactive response ratio0.10.10.4-0.4-0.1-0.50.40.10.60.0-0.4-0.4-0.1-0.6-0.4-0.3-0.30.2
Condit. Reinf. active responses0.91.22.1-0.7-1.3-1.20.91.21.2-1.1-1.0-1.1-1.20.8-1.1-0.71.11.5
Condit. Reinf. inactive responses3.54.66.7-1.7-2.1-2.11.92.42.0-2.5-1.9-2.1-2.42.0-2.2-1.72.32.6
Incentive salience index mean0.30.41.70.6-1.20.0-0.40.80.00.00.50.4-0.41.30.10.41.10.0
Condit. Reinf. lever presses0.71.15.70.9-1.60.5-0.70.8-0.6-0.00.90.8-0.42.40.50.91.6-0.3
Condit. Reinf. active minus inactive responses1.21.83.31.11.61.2-1.0-1.6-1.01.71.01.21.4-1.81.31.0-1.7-0.9
Condit. Reinf. active-inactive response ratio2.64.15.41.82.12.0-1.7-2.2-1.82.32.02.22.1-2.02.11.5-2.1-2.2
Condit. Reinf. active responses0.20.31.10.40.80.2-0.3-0.7-0.30.80.20.30.6-1.00.40.6-0.9-0.1
Condit. Reinf. inactive responses0.71.02.6-0.9-0.5-1.40.90.71.0-0.9-1.5-1.4-1.00.2-1.2-0.30.31.6
Condit. Reinf. lever presses0.00.00.20.10.1-0.40.00.10.30.2-0.10.00.1-0.30.00.3-0.10.4
Condit. Reinf. lever reinforcers received0.30.41.00.50.80.2-0.5-0.6-0.30.90.30.40.7-1.00.50.7-0.9-0.1
Conditioned reinforcement - actives0.10.20.8-0.5-0.1-0.40.50.40.6-0.5-0.2-0.7-0.5-0.1-0.5-0.90.20.3
Conditioned reinforcement - inactives0.00.10.4-0.40.2-0.30.4-0.00.3-0.3-0.2-0.4-0.0-0.6-0.2-0.7-0.3-0.1
Conditioned locomotion0.10.10.50.20.30.2-0.3-0.1-0.2-0.00.70.10.1-0.20.30.1-0.3-0.7
Patch foraging indifference point 0 sec0.41.33.2-1.30.8-1.01.0-0.50.6-0.5-1.7-1.8-0.0-1.6-1.1-0.7-1.11.4
Patch foraging indifference point AUC0.20.41.20.80.81.1-0.6-0.7-0.30.60.60.60.6-0.80.50.0-0.6-0.7
Delay disc. indifference point, 0s delay0.50.61.10.90.31.1-0.9-0.6-0.90.80.91.10.50.20.90.5-0.0-1.0
Delay disc. indifference point, 16s delay0.30.41.9-0.8-0.2-0.00.50.10.5-0.6-0.8-0.7-0.1-0.3-0.6-1.40.10.4
Delay disc. indifference point, 2s delay2.52.84.61.71.42.0-1.8-1.7-1.41.81.51.72.2-1.61.61.3-1.6-1.7
Delay disc. indifference point, 24s delay0.30.41.60.20.90.4-0.3-0.9-0.40.50.00.01.1-1.30.40.2-1.0-0.2
Delay disc. indifference point, 4s delay1.31.43.21.31.81.3-1.2-1.4-0.91.30.70.91.1-1.61.00.6-1.3-0.7
Delay disc. indifference point, 8s delay0.00.00.30.2-0.10.6-0.2-0.0-0.1-0.1-0.00.20.10.0-0.0-0.20.2-0.1
Indifference point function ln k0.20.51.00.9-0.20.8-1.0-0.2-0.60.60.90.80.80.20.50.9-0.0-1.0
Indifference point function log k0.20.51.00.9-0.20.8-1.0-0.2-0.60.60.90.80.80.20.50.9-0.0-1.0
Patch foraging total patch changes 0 sec0.51.43.4-1.40.8-1.01.0-0.40.7-0.5-1.8-1.8-0.0-1.6-1.1-0.9-1.01.5
Patch foraging total patch changes 12 sec0.50.71.8-1.00.9-0.60.7-0.30.5-0.4-1.3-1.20.1-1.3-0.7-0.8-0.71.0
Patch foraging total patch changes 18 sec1.74.08.1-2.6-0.7-2.32.31.12.0-1.8-2.5-2.5-1.80.0-2.0-2.20.72.9
Patch foraging total patch changes 24 sec1.24.16.7-2.6-1.3-2.32.41.62.1-2.2-2.6-2.4-1.80.6-2.3-2.21.12.0
Patch foraging total patch changes 6 sec1.01.85.0-1.70.4-1.31.20.10.9-1.0-2.1-2.0-0.2-1.2-1.3-1.2-0.52.2
Patch foraging time to switch 0 sec0.41.33.2-1.8-0.7-1.61.40.80.7-1.1-1.4-1.3-1.20.8-0.9-0.90.61.5
Patch foraging water rate 0 sec0.10.30.60.20.50.7-0.5-0.8-0.60.60.40.40.8-0.70.50.1-0.7-0.8
Patch foraging water rate 12 sec0.31.11.6-1.0-1.1-1.11.21.01.2-1.1-0.9-1.0-1.10.6-1.0-1.20.90.9
Patch foraging water rate 18 sec0.00.10.60.10.80.10.1-0.3-0.0-0.0-0.3-0.2-0.4-0.4-0.1-0.2-0.3-0.3
Patch foraging water rate 24 sec0.10.10.9-0.20.10.20.4-0.00.3-0.3-0.2-0.4-0.5-0.2-0.4-1.0-0.0-0.4
Patch foraging water rate 6 sec0.20.30.5-0.7-0.7-0.50.50.40.5-0.5-0.6-0.7-0.30.1-0.6-0.70.30.2
Seeking ratio, delayed vs. immediate footshock0.30.42.00.60.90.3-0.1-0.9-0.00.30.0-0.10.4-1.4-0.10.2-1.1-0.6
Distance traveled before self-admin0.10.20.50.50.60.6-0.4-0.1-0.70.30.70.5-0.20.20.70.6-0.1-0.4
Distance traveled after self-admin0.81.43.61.11.91.0-0.9-1.4-1.01.10.91.01.0-1.61.01.0-1.6-1.0
Extensor digitorum longus weight0.20.71.41.00.90.9-1.1-0.8-1.20.90.60.60.8-0.30.91.1-0.6-0.1
Bone: elastic displacement0.50.61.1-0.7-0.0-0.60.80.61.0-0.7-1.0-1.0-0.7-0.2-1.0-1.00.30.9
Bone: elastic work0.10.20.7-0.00.70.30.0-0.20.10.2-0.4-0.30.1-0.6-0.0-0.6-0.10.8
Bone: endosteal estimation5.914.518.54.14.03.9-4.0-4.0-4.14.33.53.53.8-2.94.14.1-3.5-2.8
Bone: endosteal perimeter3.17.711.93.32.02.8-3.2-2.5-3.22.93.13.22.7-1.13.23.4-1.9-2.1
Epididymis fat weight3.618.037.4-6.1-1.6-4.95.12.24.0-4.0-5.4-5.4-3.4-0.2-4.7-5.21.04.8
Delta time in closed arm before/after self-admin0.50.41.10.20.60.4-0.5-1.1-0.70.80.30.21.0-0.60.60.5-0.9-0.6
Delta time in open arm before/after self-admin0.30.30.9-0.20.5-0.30.50.60.6-0.8-0.6-0.5-0.9-0.3-0.6-0.50.10.7
Diff in mean of infusions in LGA sessions1.01.97.7-1.0-2.8-1.10.71.70.9-1.4-0.2-0.3-1.02.4-0.8-0.62.00.0
Delay discount exponential model param0.30.51.2-0.7-0.8-1.10.80.80.5-0.6-0.3-0.5-0.90.9-0.5-0.00.60.5
Extinction: sum of active levers before priming0.40.61.40.6-0.40.6-0.8-0.5-0.70.71.11.11.20.30.90.9-0.1-1.1
Active lever presses in extinction session 60.50.50.8-0.9-0.5-0.70.80.60.8-0.8-0.9-0.6-0.50.1-0.7-0.70.30.8
Bone: final force0.30.41.5-0.51.20.30.3-0.8-0.20.2-0.7-0.7-0.1-1.0-0.1-1.1-0.70.4
Bone: final moment0.30.41.7-0.41.30.40.3-0.8-0.20.1-0.7-0.7-0.1-1.1-0.1-1.0-0.80.3
Food consumed during 24 hour testing period0.30.61.50.91.01.1-0.8-0.9-1.20.60.30.30.4-0.20.70.8-0.6-0.5
Glucose4.26.711.63.31.12.9-3.3-1.8-3.02.03.02.92.5-0.22.73.4-1.1-3.0
Heart weight2.43.88.01.32.11.7-1.7-2.4-1.82.01.21.22.8-2.81.51.5-2.6-1.5
Delay discount hyperbolic model param0.50.71.4-0.8-0.9-1.20.91.00.6-0.8-0.4-0.6-1.11.1-0.6-0.20.80.6
Intermittent access intake day 1-15 change0.00.20.5-0.1-0.1-0.30.40.40.5-0.4-0.5-0.4-0.70.1-0.4-0.40.30.5
Intermittent access intake escalation0.20.91.9-0.6-0.0-0.81.00.81.2-0.9-1.2-1.1-1.4-0.2-1.2-1.10.41.1
Intermittent access intake escalation 20.00.10.50.60.30.10.10.10.20.2-0.0-0.1-0.70.1-0.2-0.10.2-0.0
Intermitt. access day 1 inactive lever presses0.23.15.21.70.81.7-1.7-1.5-1.82.02.32.31.9-0.22.21.6-0.8-2.2
Intermitt. access day 15 inactive lever presses0.10.51.20.61.10.6-0.5-0.9-0.60.90.40.40.7-0.80.80.4-0.8-0.1
Intermitt. access escalation Index0.30.83.3-0.1-1.6-0.50.11.40.4-0.7-0.00.2-0.51.8-0.30.21.60.5
Intermittent access day 1 total infusions0.41.22.6-1.0-1.3-0.80.91.61.2-1.3-0.8-1.1-1.00.9-1.1-1.01.20.9
Intermittent access day 15 total infusions0.71.62.6-1.0-0.7-1.01.31.51.6-1.5-1.3-1.5-1.60.3-1.5-1.40.91.1
Intermittent access terminal intake (last 3 days)0.30.51.3-0.7-0.2-0.40.70.81.0-0.9-0.9-1.1-0.6-0.4-0.9-0.90.20.8
Intermittent access total infusions0.60.71.4-0.7-0.3-0.60.81.01.1-1.2-0.9-1.2-0.9-0.1-1.1-0.90.40.6
Intermittent access day 1 locomotion0.40.71.7-0.7-0.4-0.90.81.10.8-1.1-0.6-0.9-1.30.5-0.8-0.50.70.7
Intermittent access day 15 total locomotion0.00.10.80.10.9-0.00.20.20.1-0.2-0.0-0.5-0.8-0.4-0.1-0.3-0.20.1
Intermittent access total locomotion0.30.41.6-0.20.5-0.40.60.50.6-0.7-0.4-0.9-1.3-0.2-0.6-0.80.10.3
Intermittent access standard deviation0.10.62.5-0.61.10.00.5-0.60.1-0.2-0.8-0.90.0-1.6-0.3-0.6-1.10.5
Left kidney weight0.43.314.30.53.81.5-0.3-2.7-1.31.4-0.5-0.40.8-3.40.6-0.1-2.90.6
Right kidney weight0.43.114.40.73.81.6-0.4-2.6-1.41.5-0.6-0.80.4-2.90.6-0.2-2.51.2
Cocaine induced anxiety0.10.41.00.70.00.3-0.6-0.2-0.60.30.80.90.30.40.80.90.0-1.0
Post-drug Anxiety0.50.51.20.50.40.3-0.7-0.7-0.70.60.70.71.0-0.40.81.1-0.8-1.0
Baseline Anxiety0.10.21.6-0.5-0.3-0.2-0.2-0.4-0.20.40.0-0.11.3-0.70.00.3-0.70.3
Tail length2.312.524.64.15.04.1-3.4-4.2-3.43.82.32.23.1-4.13.12.9-3.9-1.9
Length with tail3.415.233.44.45.84.7-3.7-4.8-4.14.22.62.33.0-4.23.53.0-4.2-1.9
Length without tail1.47.216.22.54.03.2-2.5-3.6-3.43.01.81.52.0-2.42.61.9-2.9-1.4
Times rat made contact with spout3.43.95.9-1.9-1.3-2.12.02.02.4-2.2-2.2-2.3-1.90.6-2.4-1.91.42.3
Lifetime Intake0.40.51.1-0.6-0.1-0.40.60.80.9-1.0-0.7-1.0-0.7-0.2-0.9-0.80.30.5
Liver weight, left2.74.77.12.62.32.3-2.4-2.3-2.72.21.81.71.9-1.32.32.6-1.9-1.9
Liver weight, right3.35.89.33.02.73.0-2.8-2.4-2.82.72.22.12.1-1.42.62.3-1.7-1.5
Locomotor activity2.23.57.22.32.71.9-1.9-2.0-1.51.81.51.51.2-2.01.61.9-2.1-1.6
Locomotor testing distance0.81.92.51.41.61.3-1.4-1.5-1.31.31.21.31.3-1.31.21.6-1.5-1.3
Locomotor testing rearing0.31.22.91.11.71.1-1.1-1.3-1.21.20.80.80.8-1.11.01.3-1.3-0.5
Locomotion in novel chamber0.00.10.30.10.40.00.1-0.00.1-0.1-0.3-0.1-0.4-0.1-0.1-0.50.10.2
Locomotion in novel chamber post-restriction0.10.31.3-0.30.90.30.2-0.7-0.30.4-0.5-0.40.4-1.2-0.1-0.0-1.00.5
Fecal boli incidents, locomotor time 10.10.10.7-0.5-0.3-0.80.40.00.2-0.4-0.4-0.3-0.20.0-0.40.1-0.20.2
Change in fecal boli incidents, locomotor task2.42.64.81.30.72.0-1.7-1.4-1.81.71.81.82.2-0.61.71.3-0.9-2.1
Time >=10cm from walls, locomotor time 12.12.63.71.31.81.4-1.5-1.9-1.91.71.51.21.7-1.11.81.8-1.6-1.3
Bouts of movement, locomotor time 10.30.31.00.2-0.5-0.40.20.90.5-0.6-0.2-0.1-0.91.0-0.4-0.11.00.5
Total resting periods, locomotor time 10.20.20.70.3-0.2-0.1-0.10.70.2-0.30.00.1-0.70.8-0.2-0.00.80.4
Rest time, locomotor task time 10.40.61.31.11.10.7-0.8-0.8-0.60.70.60.70.5-0.70.60.8-0.8-0.6
Distance moved, locomotor task time 10.00.00.1-0.4-0.00.10.2-0.10.00.1-0.0-0.10.3-0.20.1-0.3-0.10.1
Vertical activity count, locomotor time 10.00.10.4-0.6-0.2-0.40.50.00.4-0.2-0.4-0.5-0.2-0.2-0.3-0.5-0.10.4
Time >=10cm from walls, locomotor time 21.02.95.61.21.51.5-1.5-2.0-1.91.81.51.22.4-1.41.72.2-1.9-1.2
Bouts of movement, locomotor time 20.10.41.71.31.30.8-0.5-0.4-0.20.50.20.1-0.1-0.70.20.5-0.4-0.1
Total resting periods, locomotor time 20.20.72.91.71.41.1-0.9-0.6-0.50.80.60.50.2-0.70.50.9-0.5-0.4
Rest time, locomotor task time 20.71.13.01.70.71.2-1.2-0.3-1.21.01.21.30.40.61.31.50.1-0.6
Distance moved, locomotor task time 20.30.41.7-1.3-0.2-0.50.8-0.20.5-0.4-0.7-0.7-0.1-0.3-0.5-0.9-0.30.2
Vertical activity count, locomotor time 20.10.20.6-0.8-0.0-0.40.4-0.50.1-0.0-0.2-0.30.4-0.60.0-0.1-0.7-0.1
Light reinforcement 10.00.20.8-0.9-0.5-0.40.40.0-0.1-0.4-0.4-0.4-0.30.5-0.2-0.60.30.2
Light reinforcement 20.10.20.60.30.60.5-0.4-0.5-0.70.30.30.3-0.30.20.50.1-0.1-0.4
Bone: marrow area5.814.318.24.04.13.8-4.0-4.1-4.14.33.33.43.8-3.14.04.1-3.6-2.7
Bone: maximum diameter1.83.76.32.51.02.3-2.2-1.5-2.12.02.42.41.7-0.42.31.9-0.9-1.7
Bone: maximum force0.20.41.7-0.01.30.60.0-0.9-0.50.3-0.5-0.40.1-1.00.2-0.7-0.70.2
Bone: maximum moment0.20.42.00.21.40.7-0.1-1.0-0.50.4-0.4-0.40.1-1.10.2-0.5-0.90.0
Mean time between licks in bursts0.42.55.12.30.52.0-1.8-0.9-1.61.61.92.01.00.31.61.8-0.3-2.1
Mean num. licks in bursts2.05.410.6-2.3-0.5-2.42.51.62.4-2.5-3.2-3.3-2.3-0.1-2.8-2.30.83.0
Cd content in liver1.11.21.9-1.4-0.7-1.21.20.80.8-1.1-1.2-1.2-1.30.9-1.0-1.00.81.2
Co content in liver0.30.41.2-1.10.2-0.70.6-0.30.2-0.2-0.8-0.90.2-0.7-0.3-0.6-0.60.9
Cu content in liver3.13.75.6-2.0-1.8-2.32.12.12.4-2.2-1.9-1.7-1.90.9-2.2-1.91.41.7
Fe content in liver0.50.61.3-1.10.1-0.81.00.10.7-0.7-1.1-1.1-0.7-0.3-0.9-1.1-0.10.9
K content in liver0.60.51.8-0.6-1.4-0.30.40.90.4-0.8-0.4-0.1-0.61.2-0.5-0.81.1-0.1
Mg content in liver0.91.02.11.0-0.90.9-1.10.0-1.00.61.31.30.81.20.90.90.5-1.4
Mn content in liver2.32.65.31.9-0.01.4-2.1-0.8-2.01.42.11.91.40.71.92.3-0.2-1.7
Na content in liver0.50.61.6-0.7-1.1-0.50.60.91.0-0.8-0.6-0.3-0.50.4-0.8-1.30.80.5
Rb content in liver0.20.31.1-0.5-0.8-0.50.20.60.0-0.7-0.4-0.3-0.41.0-0.3-0.00.80.2
Se content in liver2.42.95.92.40.71.9-2.3-0.9-1.61.62.32.01.5-0.11.71.9-0.5-2.0
Sr content in liver0.70.61.10.70.90.7-0.9-0.9-0.91.10.80.80.6-0.61.00.7-0.8-0.5
Zn content in liver0.10.10.40.40.10.4-0.6-0.3-0.60.10.30.30.30.10.30.5-0.1-0.4
Bone: minimum diameter2.44.66.82.61.82.4-2.5-2.1-2.62.22.22.22.0-1.02.42.5-1.5-1.5
Time in familiar zone, hab. session 15.35.99.9-2.3-1.8-2.72.42.52.7-2.5-2.7-2.5-2.41.2-2.6-2.12.03.2
Time in novel zone, hab. session 14.44.98.02.02.02.3-2.1-2.5-2.42.12.12.02.3-1.62.32.1-2.2-2.8
Total zone transitions, hab. session 10.30.51.4-0.3-1.2-0.60.30.80.3-0.8-0.5-0.4-0.30.9-0.4-0.21.01.1
Total locomotion distance, hab. session 10.50.72.0-0.5-1.4-0.60.51.00.4-0.9-0.5-0.3-0.51.1-0.5-0.41.21.2
Locomotion velocity, hab. session 10.30.41.5-0.4-1.2-0.50.30.70.3-0.7-0.5-0.3-0.10.8-0.4-0.40.90.9
Time in familiar zone, hab. session 21.21.42.7-1.1-0.6-1.41.11.01.3-1.3-1.4-1.6-1.20.3-1.3-1.00.71.7
Time in novel zone, hab. session 20.60.61.80.60.80.8-0.5-0.9-0.70.80.60.80.8-0.80.70.6-1.0-1.3
Total zone transitions, hab. session 20.30.31.0-0.5-1.0-0.40.30.60.3-0.30.00.1-0.41.00.0-0.51.00.7
Total locomotion distance, hab. session 21.11.44.2-1.0-2.1-1.00.71.40.7-1.0-0.4-0.2-1.02.0-0.5-0.71.80.9
Locomotion velocity, hab. session 21.11.55.0-0.8-2.2-0.90.61.50.7-0.9-0.2-0.0-0.92.2-0.4-0.72.01.1
Novel to familiar place preference ratio0.00.10.3-0.1-0.5-0.00.00.30.2-0.10.00.20.10.2-0.1-0.30.30.0
Novelty place preference0.00.00.10.2-0.20.3-0.20.10.00.20.20.40.4-0.10.2-0.10.1-0.1
Time in novel zone, NPP test0.10.10.30.30.00.4-0.3-0.1-0.10.40.40.50.5-0.30.30.0-0.2-0.3
Total zone transitions, NPP test0.71.03.5-0.6-1.7-0.80.51.30.6-1.0-0.3-0.2-1.01.9-0.5-0.51.60.6
Total locomotion distance, NPP test1.31.84.8-1.3-2.2-1.21.01.50.8-1.5-0.7-0.7-1.32.2-0.9-0.91.90.7
Locomotion velocity, NPP test1.92.77.2-1.5-2.6-1.41.21.91.0-1.8-0.9-0.8-1.52.7-1.1-1.12.31.0
Intraocular pressure1.01.63.7-1.3-0.9-1.41.51.21.3-1.3-1.2-1.2-1.91.0-1.2-1.01.11.2
Delta distance traveled before/after self-admin1.31.55.30.81.70.8-0.6-1.6-0.51.10.40.71.5-2.30.60.5-1.9-0.9
Delta ambulatory time before/after self-admin0.91.53.91.01.60.9-0.9-1.6-0.71.20.60.91.5-2.00.80.7-1.8-1.1
Parametrial fat weight0.41.03.7-1.20.7-0.81.4-0.00.7-0.9-1.1-1.2-1.9-0.0-0.8-1.4-0.10.7
Pavlov. Cond. lever latency1.31.64.2-2.10.6-1.61.6-0.21.0-0.8-1.8-1.6-0.5-1.4-1.1-1.2-0.91.2
Pavlov. Cond. magazine entry latency0.81.13.51.9-0.21.1-1.3-0.0-0.60.71.51.50.60.40.91.30.2-1.0
Pavlov. Cond. change in total contacts0.90.93.01.70.51.5-1.3-0.3-0.70.91.41.30.6-0.11.00.80.0-0.5
Pavlov. Cond. index score1.31.74.82.2-0.51.5-1.70.1-0.90.81.91.70.61.11.11.50.6-1.4
Pavlov. Cond. latency score1.51.95.32.3-0.51.7-1.80.1-1.00.92.01.80.61.11.31.40.7-1.3
Pavlov. Cond. lever contacts1.51.84.02.0-0.51.7-1.7-0.0-1.20.91.91.80.61.41.31.30.8-1.2
Pavlov. Cond. magazine entry number0.50.72.0-1.40.2-0.71.1-0.00.4-0.6-1.1-1.1-0.5-0.3-0.7-1.3-0.10.5
Pavlov. Cond. intertrial magazine entries2.53.05.2-2.3-0.9-2.12.11.21.6-1.9-2.1-2.3-1.70.5-2.0-1.70.71.6
Pavlov. Cond. lever-magazine prob. diff.1.11.44.12.0-0.61.4-1.50.2-0.80.61.71.60.41.11.01.40.7-1.3
Pavlov. Cond. response bias0.91.13.31.8-0.41.1-1.30.0-0.80.61.51.50.50.80.91.40.4-1.2
Pavlov. Cond. lever latency0.30.51.20.70.21.1-0.8-0.6-1.00.60.70.60.70.20.70.6-0.1-0.9
Pavlov. Cond. magazine entry latency0.10.20.60.60.30.6-0.4-0.1-0.30.60.70.80.10.20.70.10.2-0.4
Pavlov. Cond. change in total contacts0.10.10.60.00.5-0.00.1-0.20.30.60.30.50.2-0.80.3-0.1-0.5-0.2
Pavlov. Cond. index score0.00.00.20.20.4-0.0-0.00.00.20.30.20.2-0.0-0.30.20.0-0.10.1
Pavlov. Cond. latency score0.00.00.20.10.4-0.10.0-0.00.20.30.10.10.0-0.40.2-0.1-0.10.3
Pavlov. Cond. lever contacts0.20.30.8-0.6-0.1-0.90.70.40.9-0.4-0.6-0.4-0.6-0.2-0.5-0.50.00.7
Pavlov. Cond. magazine entry number0.00.10.1-0.1-0.2-0.1-0.0-0.2-0.1-0.2-0.4-0.30.3-0.3-0.30.3-0.3-0.1
Pavlov. Cond. intertrial magazine entries0.20.41.21.1-0.20.5-0.9-0.0-0.50.40.60.50.40.40.41.10.1-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.10.3-0.10.00.10.20.20.10.2-0.1-0.20.2-0.0-0.00.3
Pavlov. Cond. response bias0.10.10.3-0.0-0.1-0.30.30.40.5-0.00.10.2-0.50.2-0.0-0.20.30.1
Time in closed arm before self-admin0.30.41.00.40.30.6-0.6-0.7-0.60.70.60.91.0-0.40.70.8-0.6-0.7
Time in closed arm after self-admin0.10.10.5-0.2-0.00.2-0.2-0.5-0.20.5-0.10.10.7-0.30.2-0.2-0.2-0.1
Time in open arm before self-admin0.00.00.30.5-0.2-0.0-0.00.20.2-0.10.1-0.2-0.20.1-0.20.10.30.1
Time in open arm after self-admin0.10.10.50.50.7-0.00.00.20.1-0.4-0.0-0.0-0.2-0.6-0.10.5-0.4-0.1
Bone: periosteal estimation2.97.09.42.83.12.8-2.7-3.0-2.92.92.22.22.7-2.42.72.5-2.6-1.7
Bone: periosteal perimeter1.63.25.12.31.52.1-2.0-1.7-2.01.81.92.01.7-1.12.01.8-1.3-1.4
Bone: post-yield work1.22.04.21.71.21.4-1.6-1.4-1.91.31.31.31.1-0.41.62.1-1.0-1.1
Progressive ratio test 1 active lever presses0.00.10.2-0.4-0.30.00.20.30.2-0.4-0.3-0.50.2-0.1-0.3-0.20.10.3
Progressive ratio test 1 breakpoint0.00.10.2-0.4-0.30.10.10.20.2-0.3-0.2-0.40.3-0.1-0.2-0.10.00.2
Progressive ratio test 1 inactive lever presses0.30.92.0-1.4-1.0-1.21.00.71.0-0.8-0.7-0.9-0.70.6-0.6-1.20.70.8
Progressive ratio test 2 active lever presses0.81.21.9-1.0-1.3-1.01.01.41.2-1.2-0.7-1.2-1.10.9-1.1-1.11.10.8
Progressive ratio test 2 breakpoint1.11.42.1-1.1-1.3-1.01.11.51.4-1.3-0.8-1.3-1.30.9-1.3-1.21.20.8
Progressive ratio test 2 inactive lever presses0.00.10.30.4-0.00.5-0.30.0-0.20.10.60.20.30.10.40.10.1-0.5
Incentive Sensitization - Responses0.20.71.4-0.4-1.1-0.80.61.21.1-0.7-0.3-0.6-0.90.8-0.8-0.61.00.6
Incentive Sensitization - Breakpoint0.41.02.0-0.6-1.2-1.00.91.41.3-0.9-0.5-0.8-1.21.0-1.0-0.91.20.8
Sum of active levers in priming session hrs 5-60.30.30.60.50.30.3-0.5-0.5-0.40.60.30.60.8-0.40.40.7-0.5-0.6
Progressive ratio0.41.15.3-0.12.10.3-0.1-1.2-0.30.6-0.6-0.70.4-2.3-0.1-0.3-1.70.9
Food seeking constrained by brief footshock0.10.20.3-0.30.2-0.50.30.30.5-0.4-0.5-0.6-0.3-0.3-0.5-0.1-0.10.4
Seeking ratio, punishment vs. effort0.30.62.50.2-1.6-0.2-0.20.70.2-0.40.80.70.21.50.20.60.9-1.1
Retroperitoneal fat weight0.20.82.8-0.8-0.0-0.50.90.50.6-1.0-0.9-0.9-1.70.6-0.8-1.40.60.9
Reaction time number correct0.20.72.0-1.40.2-1.01.1-0.30.5-0.6-1.3-1.2-0.1-1.0-0.8-0.7-0.80.5
Reaction time mean minus median0.10.72.81.70.30.8-0.60.7-0.0-0.10.50.3-1.41.30.00.51.20.1
Reaction time mean minus median AUC0.10.62.31.2-0.00.5-0.30.90.1-0.20.40.3-1.31.5-0.10.21.30.2
Reaction time num false alarms0.30.61.40.90.11.1-0.9-0.3-0.60.80.91.20.80.10.70.30.0-1.0
Reaction time num false alarms AUC0.51.22.51.30.41.5-1.3-0.7-0.91.21.31.61.3-0.31.10.6-0.4-1.6
Reaction time trials correct on left0.20.72.0-1.40.2-1.01.1-0.30.5-0.6-1.3-1.2-0.1-1.0-0.8-0.7-0.80.5
Reaction time trials on left0.20.71.8-1.30.3-0.91.0-0.30.5-0.5-1.2-1.1-0.1-1.0-0.7-0.7-0.80.4
Reaction time mean0.61.32.91.7-0.01.1-1.20.2-0.90.91.71.4-0.51.71.11.10.9-1.3
Reaction time mean AUC0.51.22.81.6-0.01.0-1.10.2-0.80.81.61.3-0.61.71.01.00.9-1.2
Median of all reaction times0.81.33.21.3-0.10.9-1.1-0.1-1.01.11.81.5-0.01.41.31.10.6-1.4
Reaction time omissions0.61.02.41.50.21.1-1.10.0-0.80.61.51.4-0.31.11.01.00.5-1.3
Reaction time false alarm rate1.62.24.72.00.31.9-1.9-0.6-1.21.52.02.21.40.21.51.1-0.0-1.7
Reaction time premature initiation rate0.30.51.10.21.10.8-0.5-1.0-0.80.90.50.50.9-0.80.80.2-0.9-0.2
Reaction time premature initiations0.20.62.1-0.51.20.20.1-1.2-0.60.7-0.1-0.10.9-1.40.4-0.1-1.40.1
Std. dev. reaction times0.41.45.32.30.71.6-1.4-0.0-0.80.91.51.4-0.30.91.01.20.6-1.0
Reaction time trials completed0.20.71.8-1.30.3-0.91.0-0.30.5-0.5-1.2-1.1-0.1-1.0-0.7-0.7-0.80.4
Reaction time trials AUC0.20.71.9-1.40.1-1.01.1-0.30.5-0.5-1.2-1.1-0.2-0.9-0.8-0.7-0.70.5
Run reversals in cocaine runway, females0.50.61.6-1.1-0.3-0.60.80.70.6-0.7-0.9-0.9-0.70.1-0.8-0.80.41.3
Run reversals in cocaine runway, males0.40.42.11.40.80.9-0.7-0.1-0.50.50.70.6-0.40.30.60.50.2-0.4
Latency to leave start box in cocaine runway0.40.51.10.5-0.80.5-0.7-0.1-0.50.50.90.91.00.90.70.50.5-1.1
Latency to leave start box in cocaine runway, F0.20.30.90.3-0.90.1-0.40.1-0.20.20.70.50.60.90.40.40.6-0.6
Latency to leave start box in cocaine runway, M0.30.30.70.40.00.7-0.5-0.5-0.60.60.40.60.60.10.50.0-0.0-0.9
Std. dev. time between licks in bursts3.46.49.82.81.32.8-2.8-2.0-2.62.93.03.12.6-0.62.72.7-1.4-3.1
Total sessions with >9 infusions0.20.20.4-0.30.20.10.30.50.6-0.7-0.4-0.5-0.2-0.5-0.6-0.5-0.00.6
Short access day 1 total inactive lever presses0.61.22.21.41.21.4-1.0-1.0-0.91.01.41.10.7-0.51.10.7-0.7-1.5
Short access day 10 total inactive lever presses0.00.31.6-0.0-1.0-0.40.20.60.3-0.40.20.5-0.51.20.1-0.31.0-0.3
Short access day 1 total infusions0.00.10.2-0.0-0.0-0.0-0.30.40.2-0.4-0.0-0.30.3-0.2-0.10.10.10.4
Short access day 10 total infusions0.50.81.4-0.8-0.5-0.40.91.01.0-1.1-0.9-1.1-1.10.4-0.9-1.20.80.7
Short access total infusions0.20.30.6-0.5-0.1-0.10.40.60.6-0.8-0.4-0.7-0.4-0.1-0.6-0.70.30.4
Short access day 1 locomotion0.40.61.8-0.4-1.3-0.40.21.30.5-1.00.0-0.4-0.51.3-0.5-0.21.30.3
Short access day 10 total locomotion0.83.25.01.51.81.8-1.7-1.8-1.81.81.71.42.2-1.71.82.0-1.9-1.7
Short access total locomotion0.40.71.40.60.50.9-0.9-0.5-0.90.51.10.81.0-0.40.91.0-0.6-1.2
One hour access (0.3 mA shock)1.51.84.5-0.6-2.1-0.90.81.91.3-1.2-0.5-0.8-1.52.0-1.0-1.02.00.6
Compulsive drug intake0.91.33.80.8-1.50.5-1.10.6-0.90.51.51.60.72.01.01.31.2-1.1
One hour access (shock baseline)0.92.44.9-1.2-0.4-1.21.71.41.9-1.5-1.7-2.1-2.20.3-1.8-1.90.91.7
Social response proportion2.02.54.41.31.41.2-1.6-1.8-1.71.71.31.22.1-1.61.51.8-1.9-1.0
Social responses1.52.04.21.11.31.2-1.4-1.6-1.41.41.11.22.0-1.71.21.3-1.7-1.1
Social time1.62.55.12.30.52.0-2.0-0.5-1.51.62.22.10.90.71.71.60.1-1.6
Soleus weight4.513.320.73.92.03.9-4.2-3.0-4.33.84.34.53.8-0.74.44.0-1.9-3.4
Bone: stiffness0.30.51.1-0.80.1-0.50.90.10.4-0.7-1.1-1.0-0.7-0.1-0.7-1.00.11.0
Tibialis anterior weight0.41.32.5-1.5-0.3-1.11.40.71.2-1.0-1.6-1.4-0.9-0.1-1.3-1.40.31.3
Time to tail flick, vehicle, before self-admin0.91.13.6-0.5-1.3-0.60.71.30.8-0.9-0.4-0.4-1.61.9-0.8-0.71.60.6
Time to tail flick, vehicle, after self-admin0.10.20.50.7-0.20.4-0.60.3-0.30.20.60.60.00.60.40.70.4-0.4
Time to tail flick, test, before self-admin0.60.61.2-0.3-0.4-0.50.70.91.0-0.9-0.8-1.0-1.10.4-1.0-0.70.80.9
Time to tail flick, test, after self-admin1.61.74.8-0.3-0.9-1.11.01.61.5-0.9-1.0-1.1-2.21.4-1.5-1.21.61.1
Delta time to tail flick, vehicle, before/after SA0.10.10.3-0.3-0.4-0.50.30.50.5-0.4-0.4-0.3-0.30.1-0.4-0.30.40.2
Delta time to tail flick, test, before/after SA0.60.81.2-1.0-1.0-1.00.90.90.8-0.6-0.7-0.6-1.11.1-0.7-0.91.00.7
Tibia length3.08.213.02.83.63.1-3.0-3.5-3.42.92.12.02.8-2.62.72.7-3.1-2.2
Ambulatory time before self-admin0.00.10.30.20.20.2-0.00.4-0.0-0.10.10.1-0.60.30.1-0.00.30.3
Ambulatory time after self-admin0.91.43.51.11.91.0-0.9-1.3-0.81.20.71.01.0-1.70.90.9-1.6-0.7
Bone: tissue strength0.20.20.6-0.10.70.50.1-0.3-0.20.1-0.3-0.4-0.2-0.30.0-0.8-0.10.7
Total heroin consumption0.10.10.30.60.30.4-0.4-0.1-0.30.40.20.40.2-0.20.20.4-0.10.2
Bone: trabecular number3.15.99.8-2.4-2.7-2.32.62.72.5-2.5-2.0-1.8-3.12.6-2.4-2.52.61.2
Bone: trabecular spacing3.45.07.62.22.72.4-2.2-2.6-2.42.21.81.52.8-2.52.21.9-2.5-1.3
Bone: trabecular thickness2.53.46.1-1.9-1.9-1.92.11.91.9-1.8-1.7-1.6-2.51.9-1.9-1.81.70.8
Bone: trabecular tissue density0.20.41.00.70.60.9-0.6-0.6-0.20.70.40.50.8-1.00.40.0-0.6-0.5
Water consumed over 24 hours0.20.30.70.60.30.7-0.6-0.4-0.70.60.60.60.8-0.10.60.6-0.3-0.5
Number of responses in last shaping day3.24.111.01.91.42.3-2.3-1.8-2.02.01.91.73.3-1.82.02.1-1.7-1.6