Hub : Genes

LOC108353253

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression LOC108353253 0.48 0.16 4.1e-06 0.11 0.26 0.25 0.25 1.2e-03 5.7e-07 1.5e-06 1.1e-06
2 Adipose mRNA stability LOC108353253 0.53 0.14 0.0e+00 0.51 0.56 0.58 0.59 6.2e-66 9.3e-76 1.2e-79 7.4e-81
3 Eye gene expression LOC108353253 0.76 0.11 1.4e-05 0.18 0.14 0.19 0.21 1.2e-03 3.4e-03 7.1e-04 4.4e-04
4 PL gene expression LOC108353253 0.59 0.11 0.0e+00 0.4 0.42 0.43 0.43 4.1e-47 3.7e-50 1.4e-51 5.9e-51
5 Liver mRNA stability LOC108353253 0.33 0.12 0.0e+00 0.22 0.19 0.3 0.28 7.8e-24 1.9e-20 1.3e-33 4.3e-31
6 pVTA gene expression LOC108353253 0.55 0.1 0.0e+00 0.37 0.43 0.43 0.43 1.4e-31 1.7e-37 7.0e-38 2.0e-37
7 NAcc gene expression LOC108353253 0.4 0.09 0.0e+00 0.37 0.37 0.37 0.37 2.4e-58 2.3e-59 1.5e-59 1.0e-59
8 IL gene expression LOC108353253 0.33 0.15 4.5e-04 0.14 0.14 0.14 0.17 3.2e-04 3.4e-04 3.1e-04 8.3e-05
9 RMTg gene expression LOC108353253 0.47 0.12 1.6e-08 0.33 0.3 0.34 0.39 1.6e-09 8.3e-09 5.6e-10 2.8e-11
10 IC gene expression LOC108353253 0.6 0.11 0.0e+00 0.32 0.44 0.4 0.43 6.3e-14 5.6e-20 8.8e-18 9.5e-20
11 Adipose gene expression LOC108353253 0.8 0.08 0.0e+00 0.62 0.67 0.68 0.67 1.0e-86 5.0e-100 7.0e-103 4.1e-101
12 BLA gene expression LOC108353253 0.5 0.11 0.0e+00 0.25 0.29 0.21 0.26 1.5e-13 8.3e-16 3.0e-11 3.3e-14
13 Brain gene expression LOC108353253 0.52 0.12 0.0e+00 0.36 0.39 0.39 0.39 1.2e-34 3.4e-38 1.8e-38 1.7e-38
14 Liver gene expression LOC108353253 0.67 0.1 0.0e+00 0.53 0.29 0.61 0.31 7.6e-69 8.1e-33 1.6e-85 1.9e-35
15 LHb gene expression LOC108353253 0.35 0.13 2.4e-04 0.2 0.04 0.14 0.2 1.5e-05 3.6e-02 2.9e-04 1.9e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density2.44.26.7-2.0-2.2-2.1-2.2-2.2-2.1-2.1-1.7-1.7-2.6-2.1-2.0-2.1-2.1-1.1
Area under the delay curve0.30.41.10.60.61.10.70.70.50.50.30.50.70.7-0.10.40.50.5
BMI with tail0.30.92.6-1.60.7-0.8-1.30.5-0.3-0.6-1.3-1.2-0.50.9-1.3-0.60.8-1.0
BMI without tail0.51.78.1-0.52.20.1-0.61.60.20.3-1.0-1.00.62.8-0.6-0.12.3-0.8
Body weight1.25.118.51.54.32.41.23.42.32.10.30.31.33.40.51.53.30.2
Weight adjusted by age2.43.67.61.42.81.51.42.52.02.11.00.82.22.41.71.62.51.1
Bone surface0.10.31.10.50.30.60.30.40.40.60.60.7-0.0-0.10.20.50.21.0
Bone volume0.20.30.9-0.6-0.3-0.4-0.8-0.4-0.6-0.5-0.5-0.5-1.0-0.4-0.9-0.6-0.30.3
Breakpoint value in progressive ratio session0.00.00.20.3-0.40.00.2-0.2-0.2-0.00.20.20.1-0.20.20.0-0.3-0.1
Number of licking bursts1.42.35.21.50.01.41.70.71.31.52.32.31.6-0.21.51.80.31.9
Context. condit. distance diff. score1.41.76.71.2-1.30.60.9-0.40.90.11.51.50.0-2.11.40.9-1.12.6
Locomotion velocity, session 10.10.10.60.8-0.10.50.6-0.00.30.10.40.30.4-0.10.60.2-0.2-0.1
Locomotion distance, session 11.41.73.4-1.2-1.8-1.2-1.2-1.5-1.3-1.4-0.9-0.9-1.3-1.5-1.4-1.2-1.6-0.8
Locomotion velocity, session 20.10.10.30.6-0.50.40.4-0.30.1-0.10.50.20.1-0.60.10.2-0.50.3
Locomotion distance, session 20.91.23.4-0.7-1.8-0.7-0.6-1.4-0.7-1.2-0.4-0.6-1.1-1.8-0.9-0.7-1.7-0.8
Locomotion velocity, session 30.30.40.8-0.70.0-0.6-0.7-0.3-0.7-0.7-0.9-0.9-0.40.5-0.7-0.90.1-0.3
Locomotion distance, session 31.51.72.8-0.9-1.6-1.1-1.0-1.7-1.3-1.6-0.9-1.2-1.5-1.6-1.0-1.4-1.6-0.3
Stereotopy head waving bouts, day 32.63.14.51.91.92.11.81.81.91.81.61.71.81.41.61.71.51.8
Stereotopy head waving duration, day 32.53.04.41.62.11.81.61.91.61.81.31.52.02.01.61.61.91.5
Locomotion velocity, session 73.23.510.3-1.2-2.7-1.5-1.5-2.5-1.5-1.8-0.6-0.7-2.4-3.2-1.2-1.3-2.8-0.6
Locomotion distance, session 73.94.911.2-1.4-3.2-1.7-1.7-3.0-2.0-2.3-1.1-1.0-2.5-3.3-1.7-1.8-3.3-0.8
Stereotopy head waving bouts, day 70.60.71.51.11.21.20.80.70.30.90.50.70.61.20.00.50.70.9
Stereotopy head waving duration, day 70.60.82.01.01.41.20.70.90.50.90.40.70.61.30.10.61.00.8
Locomotion velocity, session 84.14.98.42.90.82.62.71.32.32.02.92.71.9-0.12.42.40.62.9
Locomotion distance, session 81.21.79.60.5-2.20.20.3-1.20.3-0.70.90.7-0.9-3.10.40.2-2.11.6
Degree of sensitization distance0.90.92.50.9-0.00.91.00.50.91.01.31.60.9-0.41.11.20.11.0
Degree of sensitization stereotypy0.10.10.30.40.20.50.1-0.0-0.30.20.10.3-0.10.4-0.5-0.00.00.5
Conditioned locomotion0.80.91.40.71.01.00.81.11.21.00.80.90.80.50.81.10.91.0
Cocaine response after cond. corrected0.40.42.6-0.5-1.2-0.3-0.3-0.60.0-0.40.30.3-0.4-1.6-0.20.1-1.00.5
Cocaine response after cond. not corrected0.91.01.91.00.51.11.00.91.20.91.31.21.00.01.01.20.51.4
Cocaine response before conditioning4.65.510.92.53.32.52.22.82.12.31.21.22.53.31.91.83.01.2
Saline control response1.31.85.1-1.01.6-0.8-1.00.6-0.8-0.5-2.0-2.0-0.22.3-0.9-1.31.4-1.7
Bone: connectivity density1.32.03.9-1.4-1.7-1.6-1.4-1.6-1.3-1.2-0.8-0.8-1.9-2.0-0.9-1.1-1.6-0.8
Bone: cortical apparent density1.01.42.7-1.6-0.1-1.2-1.5-0.5-1.0-1.2-1.6-1.6-0.90.2-1.3-1.3-0.1-1.3
Bone: cortical area0.20.20.70.60.70.90.40.70.60.40.20.20.40.6-0.10.30.50.2
Bone: cortical porosity0.60.72.50.90.90.80.70.70.10.70.50.51.11.60.20.21.11.0
Bone: cortical porosity1.31.42.21.41.11.31.31.00.61.21.21.11.41.50.80.91.21.3
Bone: cortical thickness1.22.16.0-1.6-0.4-0.9-1.7-0.8-1.4-1.4-1.9-1.9-1.30.2-2.4-1.7-0.5-1.4
Bone: cortical thickness2.02.44.4-2.0-0.6-1.6-1.9-0.8-1.6-1.4-2.1-1.8-1.30.2-2.0-1.8-0.4-1.8
Bone: cortical tissue density0.81.12.3-1.5-0.0-1.1-1.3-0.4-0.9-1.1-1.5-1.4-0.80.2-1.1-1.2-0.0-1.2
Condit. Reinf. active minus inactive responses0.20.20.7-0.0-0.8-0.6-0.3-0.6-0.7-0.3-0.3-0.3-0.4-0.2-0.1-0.5-0.4-0.3
Condit. Reinf. active-inactive response ratio0.10.10.4-0.4-0.1-0.5-0.4-0.1-0.60.0-0.4-0.4-0.10.6-0.3-0.40.3-0.2
Condit. Reinf. active responses0.91.22.1-0.7-1.3-1.2-0.9-1.2-1.2-1.1-1.0-1.1-1.2-0.8-0.7-1.1-1.1-1.5
Condit. Reinf. inactive responses3.74.66.7-1.7-2.1-2.1-1.9-2.4-2.0-2.5-1.9-2.1-2.4-2.0-1.7-2.2-2.3-2.6
Incentive salience index mean0.30.41.70.6-1.20.00.4-0.8-0.00.00.50.4-0.4-1.30.40.1-1.1-0.0
Condit. Reinf. lever presses0.81.15.70.9-1.60.50.7-0.80.6-0.00.90.8-0.4-2.40.90.5-1.70.3
Condit. Reinf. active minus inactive responses1.41.83.31.11.61.21.01.61.01.71.01.21.41.81.01.31.70.9
Condit. Reinf. active-inactive response ratio3.54.15.41.82.12.01.72.21.82.32.02.22.12.01.52.12.12.2
Condit. Reinf. active responses0.20.31.10.40.80.20.30.70.30.80.20.30.61.00.60.40.90.1
Condit. Reinf. inactive responses0.81.02.6-0.9-0.5-1.4-0.9-0.7-1.0-0.9-1.5-1.4-1.0-0.1-0.3-1.2-0.4-1.6
Condit. Reinf. lever presses0.00.00.20.10.1-0.4-0.0-0.1-0.30.2-0.10.00.10.30.30.00.1-0.4
Condit. Reinf. lever reinforcers received0.30.41.00.50.80.20.50.60.30.90.30.40.71.00.70.50.90.1
Conditioned reinforcement - actives0.10.20.8-0.5-0.1-0.4-0.5-0.4-0.6-0.5-0.2-0.7-0.50.1-0.9-0.5-0.2-0.3
Conditioned reinforcement - inactives0.10.10.4-0.40.2-0.3-0.40.0-0.3-0.3-0.2-0.4-0.00.6-0.7-0.20.30.1
Conditioned locomotion0.10.10.50.20.30.20.30.10.2-0.00.70.10.10.20.10.30.30.7
Patch foraging indifference point 0 sec0.71.33.2-1.30.8-1.0-1.00.5-0.6-0.5-1.7-1.8-0.01.6-0.7-1.11.1-1.4
Patch foraging indifference point AUC0.30.41.20.80.81.10.60.70.30.60.60.60.60.80.00.50.60.7
Delay disc. indifference point, 0s delay0.50.61.10.90.31.10.90.60.90.80.91.10.5-0.20.50.90.01.0
Delay disc. indifference point, 16s delay0.30.41.9-0.8-0.2-0.0-0.5-0.1-0.5-0.6-0.8-0.7-0.10.3-1.4-0.6-0.1-0.4
Delay disc. indifference point, 2s delay2.52.84.61.71.42.01.81.71.41.81.51.72.21.61.31.61.61.7
Delay disc. indifference point, 24s delay0.40.41.60.20.90.40.30.90.40.50.00.01.11.30.20.41.00.2
Delay disc. indifference point, 4s delay1.31.43.21.31.81.31.21.40.91.30.70.91.11.60.61.01.30.7
Delay disc. indifference point, 8s delay0.00.00.30.2-0.10.60.20.00.1-0.10.00.20.1-0.0-0.2-0.0-0.20.1
Indifference point function ln k0.30.51.00.9-0.20.81.00.20.60.60.90.80.8-0.20.90.50.01.0
Indifference point function log k0.30.51.00.9-0.20.81.00.20.60.60.90.80.8-0.20.90.50.01.0
Patch foraging total patch changes 0 sec0.71.43.4-1.40.8-1.0-1.00.4-0.7-0.5-1.8-1.8-0.01.6-0.9-1.11.1-1.5
Patch foraging total patch changes 12 sec0.50.71.8-1.00.9-0.6-0.70.3-0.5-0.4-1.3-1.20.11.3-0.8-0.70.8-1.0
Patch foraging total patch changes 18 sec2.64.08.1-2.6-0.7-2.3-2.3-1.1-2.0-1.8-2.5-2.5-1.8-0.0-2.2-2.0-0.6-2.9
Patch foraging total patch changes 24 sec2.44.16.7-2.6-1.3-2.3-2.4-1.6-2.1-2.2-2.6-2.4-1.8-0.6-2.2-2.3-1.1-2.0
Patch foraging total patch changes 6 sec1.21.85.0-1.70.4-1.3-1.2-0.1-0.9-1.0-2.1-2.0-0.21.2-1.2-1.30.5-2.2
Patch foraging time to switch 0 sec0.71.33.2-1.8-0.7-1.6-1.4-0.8-0.7-1.1-1.4-1.3-1.2-0.8-0.9-0.9-0.6-1.5
Patch foraging water rate 0 sec0.20.30.60.20.50.70.50.80.60.60.40.40.80.70.10.50.70.8
Patch foraging water rate 12 sec0.51.11.6-1.0-1.1-1.1-1.2-1.0-1.2-1.1-0.9-1.0-1.1-0.6-1.2-1.0-0.9-0.9
Patch foraging water rate 18 sec0.10.10.60.10.80.1-0.10.30.00.0-0.3-0.2-0.40.4-0.2-0.10.30.3
Patch foraging water rate 24 sec0.10.10.9-0.20.10.2-0.40.0-0.3-0.3-0.2-0.4-0.50.2-1.0-0.40.00.4
Patch foraging water rate 6 sec0.20.30.5-0.7-0.7-0.5-0.5-0.4-0.5-0.5-0.6-0.7-0.3-0.1-0.7-0.6-0.3-0.2
Seeking ratio, delayed vs. immediate footshock0.30.42.00.60.90.30.20.90.00.30.0-0.10.41.40.2-0.11.10.6
Distance traveled before self-admin0.20.20.50.50.60.60.40.10.70.30.70.5-0.2-0.20.60.70.10.4
Distance traveled after self-admin1.21.43.61.11.91.00.91.41.01.10.91.01.01.61.01.01.61.0
Extensor digitorum longus weight0.20.71.41.00.90.91.10.81.20.90.60.60.80.31.10.90.60.1
Bone: elastic displacement0.50.61.1-0.7-0.1-0.6-0.8-0.6-1.0-0.7-1.0-1.0-0.70.2-1.0-1.0-0.3-0.9
Bone: elastic work0.10.20.7-0.00.70.3-0.00.2-0.10.2-0.4-0.30.10.6-0.6-0.00.2-0.8
Bone: endosteal estimation6.614.518.54.14.03.94.04.04.14.33.53.53.82.94.14.13.52.8
Bone: endosteal perimeter3.67.711.93.32.02.83.22.53.22.93.13.22.71.13.43.21.92.1
Epididymis fat weight5.318.037.4-6.1-1.7-4.9-5.1-2.2-4.0-4.0-5.4-5.4-3.40.2-5.2-4.7-0.8-4.8
Delta time in closed arm before/after self-admin0.50.41.10.20.60.40.51.10.70.80.30.21.00.60.50.60.90.6
Delta time in open arm before/after self-admin0.30.30.9-0.20.5-0.3-0.5-0.6-0.6-0.8-0.6-0.5-0.90.3-0.5-0.6-0.1-0.7
Diff in mean of infusions in LGA sessions1.51.97.7-1.0-2.8-1.1-0.7-1.7-0.9-1.4-0.2-0.3-1.0-2.4-0.6-0.8-2.1-0.0
Delay discount exponential model param0.40.51.1-0.7-0.8-1.1-0.8-0.8-0.5-0.6-0.3-0.5-0.9-0.9-0.0-0.5-0.6-0.5
Extinction: sum of active levers before priming0.60.61.40.6-0.40.60.80.50.70.71.11.11.2-0.30.90.90.11.1
Active lever presses in extinction session 60.50.50.8-0.9-0.5-0.7-0.8-0.6-0.8-0.8-0.9-0.6-0.5-0.1-0.7-0.7-0.3-0.8
Bone: final force0.30.41.5-0.51.20.3-0.30.80.20.2-0.7-0.7-0.11.0-1.1-0.10.8-0.4
Bone: final moment0.30.51.7-0.41.30.3-0.30.80.20.1-0.7-0.7-0.11.1-1.0-0.10.9-0.3
Food consumed during 24 hour testing period0.40.61.50.91.01.10.80.91.20.60.30.30.40.20.80.70.60.5
Glucose4.36.711.63.31.12.93.31.83.02.03.03.02.50.23.42.71.03.0
Heart weight2.53.88.01.32.11.71.72.41.82.01.21.22.82.81.51.52.71.5
Delay discount hyperbolic model param0.60.71.4-0.8-0.9-1.2-0.9-1.0-0.6-0.8-0.4-0.6-1.1-1.1-0.2-0.6-0.8-0.6
Intermittent access intake day 1-15 change0.10.20.5-0.1-0.1-0.3-0.4-0.4-0.5-0.4-0.5-0.4-0.7-0.1-0.4-0.4-0.3-0.5
Intermittent access intake escalation0.40.91.9-0.6-0.0-0.8-1.0-0.8-1.2-0.9-1.2-1.1-1.40.2-1.1-1.2-0.3-1.1
Intermittent access intake escalation 20.10.10.50.60.30.1-0.1-0.1-0.20.2-0.0-0.1-0.7-0.0-0.1-0.2-0.20.0
Intermitt. access day 1 inactive lever presses0.83.15.21.70.81.71.71.51.82.02.32.31.90.21.62.20.82.2
Intermitt. access day 15 inactive lever presses0.20.51.20.61.10.60.50.90.60.90.40.40.70.80.40.80.80.1
Intermitt. access escalation Index0.60.83.3-0.1-1.6-0.5-0.1-1.4-0.4-0.7-0.00.2-0.5-1.80.2-0.3-1.7-0.5
Intermittent access day 1 total infusions0.71.22.6-1.0-1.3-0.8-0.9-1.6-1.2-1.3-0.8-1.1-1.0-0.9-1.0-1.1-1.2-0.9
Intermittent access day 15 total infusions1.11.62.6-1.0-0.7-1.0-1.3-1.5-1.6-1.5-1.3-1.5-1.6-0.3-1.4-1.5-0.9-1.1
Intermittent access terminal intake (last 3 days)0.40.51.3-0.7-0.2-0.4-0.7-0.8-1.0-0.9-0.9-1.1-0.60.4-0.9-0.9-0.2-0.8
Intermittent access total infusions0.60.71.4-0.7-0.3-0.6-0.8-1.0-1.1-1.2-0.9-1.2-0.90.1-0.9-1.1-0.4-0.6
Intermittent access day 1 locomotion0.50.71.7-0.7-0.4-0.9-0.8-1.1-0.8-1.1-0.6-0.9-1.3-0.5-0.5-0.8-0.7-0.7
Intermittent access day 15 total locomotion0.10.10.80.10.9-0.0-0.2-0.2-0.1-0.2-0.0-0.5-0.80.4-0.3-0.10.2-0.1
Intermittent access total locomotion0.30.41.6-0.20.5-0.4-0.6-0.5-0.6-0.7-0.4-0.9-1.30.2-0.8-0.6-0.1-0.3
Intermittent access standard deviation0.30.62.5-0.61.10.0-0.50.6-0.1-0.2-0.8-0.90.01.6-0.6-0.31.2-0.5
Left kidney weight0.73.314.30.53.81.50.32.71.31.4-0.5-0.40.83.4-0.10.63.0-0.6
Right kidney weight0.73.114.40.73.81.50.42.61.41.5-0.6-0.80.42.9-0.20.62.5-1.2
Cocaine induced anxiety0.30.41.00.70.00.30.60.20.60.30.80.90.3-0.40.90.8-0.01.0
Post-drug Anxiety0.50.51.20.50.40.30.70.70.70.60.70.71.00.41.10.80.81.0
Baseline Anxiety0.20.21.6-0.5-0.3-0.20.20.40.20.40.0-0.11.30.70.30.00.7-0.3
Tail length3.212.524.64.15.04.13.44.23.43.82.32.23.14.12.93.13.91.9
Length with tail3.515.233.44.45.84.73.74.84.14.22.62.33.04.23.03.54.31.9
Length without tail2.37.316.22.54.03.22.53.63.43.01.81.52.02.41.92.62.91.4
Times rat made contact with spout3.43.95.9-1.9-1.3-2.2-2.0-2.0-2.4-2.2-2.2-2.3-1.9-0.6-1.9-2.4-1.4-2.3
Lifetime Intake0.40.51.1-0.6-0.1-0.4-0.6-0.8-0.9-1.0-0.7-1.0-0.70.2-0.8-0.9-0.3-0.5
Liver weight, left2.94.77.12.62.32.32.42.32.72.21.91.71.91.32.62.31.91.9
Liver weight, right3.35.89.33.02.73.02.82.42.82.72.22.12.11.42.32.61.71.5
Locomotor activity2.23.57.22.32.71.91.92.01.51.81.51.51.22.01.91.62.11.6
Locomotor testing distance1.01.92.61.41.61.31.41.51.31.31.21.31.31.31.61.21.51.3
Locomotor testing rearing0.61.22.91.11.71.11.11.31.21.20.80.80.81.11.31.01.30.5
Locomotion in novel chamber0.00.10.30.10.40.0-0.10.0-0.1-0.1-0.3-0.1-0.40.1-0.5-0.1-0.1-0.2
Locomotion in novel chamber post-restriction0.20.31.3-0.30.90.3-0.20.70.30.4-0.5-0.40.41.2-0.0-0.11.0-0.5
Fecal boli incidents, locomotor time 10.10.10.7-0.5-0.3-0.8-0.4-0.0-0.2-0.4-0.4-0.3-0.2-0.00.1-0.40.2-0.2
Change in fecal boli incidents, locomotor task2.62.64.81.30.72.01.71.41.81.71.81.82.20.61.31.70.92.1
Time >=10cm from walls, locomotor time 12.42.63.71.31.81.41.51.91.91.71.51.21.71.11.81.81.61.3
Bouts of movement, locomotor time 10.30.41.10.2-0.5-0.4-0.2-0.9-0.5-0.6-0.2-0.1-0.9-1.0-0.1-0.4-1.0-0.5
Total resting periods, locomotor time 10.20.20.70.3-0.2-0.10.1-0.7-0.2-0.30.00.1-0.7-0.8-0.0-0.2-0.8-0.4
Rest time, locomotor task time 10.50.61.31.11.10.70.80.80.60.70.60.70.50.70.80.60.80.6
Distance moved, locomotor task time 10.00.00.1-0.4-0.00.1-0.20.1-0.00.1-0.0-0.10.30.2-0.30.10.1-0.1
Vertical activity count, locomotor time 10.10.10.4-0.6-0.2-0.4-0.5-0.0-0.4-0.2-0.4-0.5-0.20.2-0.5-0.30.1-0.4
Time >=10cm from walls, locomotor time 22.02.95.61.21.51.51.52.01.91.81.51.22.41.42.21.71.81.2
Bouts of movement, locomotor time 20.20.41.71.31.30.70.50.40.20.50.20.1-0.10.70.50.20.40.1
Total resting periods, locomotor time 20.40.72.91.71.41.10.90.60.50.80.60.50.20.70.90.50.50.4
Rest time, locomotor task time 20.91.13.01.70.71.21.20.31.21.01.21.30.4-0.61.51.3-0.10.6
Distance moved, locomotor task time 20.30.41.7-1.3-0.2-0.5-0.80.2-0.4-0.4-0.7-0.7-0.10.3-0.9-0.50.3-0.2
Vertical activity count, locomotor time 20.10.20.6-0.8-0.0-0.4-0.40.5-0.1-0.0-0.2-0.30.40.6-0.10.00.70.1
Light reinforcement 10.10.20.8-0.9-0.5-0.4-0.4-0.00.1-0.4-0.4-0.4-0.3-0.5-0.6-0.2-0.3-0.2
Light reinforcement 20.10.20.60.30.60.50.40.50.70.30.30.3-0.3-0.20.10.50.10.4
Bone: marrow area6.514.318.24.04.13.84.04.14.14.33.33.43.83.14.14.03.62.7
Bone: maximum diameter2.03.76.32.51.02.32.21.52.12.02.42.41.70.41.92.30.91.7
Bone: maximum force0.20.41.7-0.01.30.6-0.00.90.50.3-0.5-0.40.11.0-0.70.20.8-0.2
Bone: maximum moment0.30.42.00.21.40.70.11.00.50.4-0.4-0.40.11.1-0.50.20.9-0.0
Mean time between licks in bursts1.02.55.12.30.52.01.80.91.61.61.92.01.0-0.31.81.60.32.1
Mean num. licks in bursts3.55.410.6-2.3-0.5-2.4-2.5-1.6-2.4-2.5-3.2-3.3-2.30.1-2.3-2.8-0.8-3.0
Cd content in liver1.11.21.9-1.4-0.7-1.2-1.3-0.8-0.8-1.1-1.2-1.2-1.3-0.9-1.0-1.0-0.8-1.2
Co content in liver0.30.41.2-1.10.2-0.7-0.60.3-0.2-0.2-0.8-0.90.20.7-0.6-0.30.6-0.9
Cu content in liver3.13.75.6-2.0-1.8-2.3-2.1-2.1-2.4-2.2-1.9-1.7-1.9-0.9-1.9-2.2-1.4-1.7
Fe content in liver0.50.61.3-1.10.1-0.8-1.0-0.1-0.7-0.7-1.1-1.1-0.70.3-1.1-0.90.2-0.9
K content in liver0.60.51.8-0.6-1.4-0.3-0.4-0.9-0.4-0.8-0.4-0.1-0.6-1.2-0.8-0.5-1.10.1
Mg content in liver1.01.02.11.0-0.90.91.1-0.01.00.61.31.30.8-1.20.90.9-0.61.4
Mn content in liver2.32.65.31.9-0.01.42.00.82.01.42.11.91.4-0.72.31.90.11.7
Na content in liver0.50.61.6-0.7-1.1-0.5-0.6-0.9-1.0-0.8-0.6-0.3-0.5-0.4-1.3-0.8-0.8-0.5
Rb content in liver0.20.31.1-0.5-0.8-0.5-0.2-0.6-0.0-0.7-0.4-0.3-0.4-1.0-0.0-0.3-0.8-0.2
Se content in liver2.42.95.92.40.71.92.30.91.61.62.32.01.50.11.91.70.42.0
Sr content in liver0.70.61.10.70.90.70.90.90.91.10.80.80.60.60.71.00.80.5
Zn content in liver0.10.10.40.40.10.40.60.30.60.10.30.30.3-0.10.50.30.10.4
Bone: minimum diameter2.54.66.82.61.82.42.52.12.62.22.22.22.01.02.52.41.41.5
Time in familiar zone, hab. session 16.15.99.9-2.3-1.8-2.7-2.4-2.5-2.7-2.5-2.7-2.5-2.4-1.2-2.1-2.6-2.0-3.2
Time in novel zone, hab. session 14.94.98.02.02.02.32.12.52.42.12.12.02.31.62.12.32.22.8
Total zone transitions, hab. session 10.30.51.4-0.3-1.2-0.6-0.3-0.8-0.3-0.8-0.5-0.4-0.3-0.9-0.2-0.4-1.0-1.1
Total locomotion distance, hab. session 10.50.72.0-0.5-1.4-0.6-0.5-1.0-0.4-0.9-0.6-0.3-0.5-1.1-0.4-0.5-1.2-1.2
Locomotion velocity, hab. session 10.30.41.5-0.4-1.2-0.5-0.3-0.7-0.3-0.7-0.5-0.3-0.1-0.8-0.4-0.4-0.9-0.9
Time in familiar zone, hab. session 21.31.42.7-1.1-0.6-1.4-1.1-1.0-1.3-1.3-1.4-1.6-1.2-0.3-1.0-1.3-0.7-1.7
Time in novel zone, hab. session 20.60.61.80.60.80.80.50.90.70.80.60.80.80.80.60.71.01.3
Total zone transitions, hab. session 20.30.31.0-0.5-1.0-0.4-0.3-0.6-0.3-0.30.00.1-0.4-1.0-0.50.0-1.0-0.7
Total locomotion distance, hab. session 21.11.44.2-1.0-2.1-1.0-0.7-1.4-0.7-1.0-0.4-0.3-1.0-2.0-0.7-0.5-1.8-0.9
Locomotion velocity, hab. session 21.11.55.0-0.8-2.2-0.9-0.6-1.5-0.7-0.9-0.2-0.0-0.9-2.2-0.7-0.4-2.0-1.1
Novel to familiar place preference ratio0.00.10.3-0.1-0.5-0.0-0.0-0.3-0.2-0.10.00.20.1-0.2-0.3-0.1-0.3-0.0
Novelty place preference0.00.00.10.2-0.20.20.2-0.1-0.00.20.20.40.40.1-0.10.2-0.10.1
Time in novel zone, NPP test0.10.10.30.30.00.40.40.10.10.40.40.50.50.30.00.30.20.3
Total zone transitions, NPP test0.71.03.5-0.6-1.7-0.7-0.5-1.3-0.6-1.0-0.3-0.2-1.0-1.9-0.5-0.5-1.7-0.6
Total locomotion distance, NPP test1.31.84.8-1.3-2.1-1.2-1.0-1.5-0.8-1.5-0.7-0.7-1.3-2.2-0.9-0.9-1.9-0.7
Locomotion velocity, NPP test1.92.77.2-1.5-2.6-1.4-1.2-1.9-1.0-1.8-0.9-0.8-1.5-2.7-1.1-1.1-2.3-1.0
Intraocular pressure1.11.63.7-1.3-0.9-1.4-1.5-1.2-1.3-1.3-1.2-1.2-1.9-1.0-1.0-1.2-1.1-1.2
Delta distance traveled before/after self-admin1.41.55.30.81.70.80.71.60.51.10.40.71.52.30.50.61.90.9
Delta ambulatory time before/after self-admin1.31.53.91.01.60.90.91.60.71.20.60.91.52.00.70.81.81.1
Parametrial fat weight0.41.03.7-1.20.7-0.8-1.40.0-0.7-0.9-1.1-1.2-1.90.0-1.4-0.80.1-0.7
Pavlov. Cond. lever latency1.31.64.2-2.10.6-1.6-1.60.2-1.0-0.8-1.8-1.6-0.51.4-1.2-1.11.0-1.2
Pavlov. Cond. magazine entry latency0.81.13.51.9-0.21.11.30.00.60.71.51.50.6-0.41.30.9-0.21.0
Pavlov. Cond. change in total contacts0.90.93.01.70.51.41.30.30.70.91.41.30.60.10.81.0-0.00.5
Pavlov. Cond. index score1.31.74.82.2-0.51.51.7-0.10.90.81.91.70.6-1.01.51.1-0.71.4
Pavlov. Cond. latency score1.51.95.32.3-0.51.71.8-0.11.00.92.01.80.6-1.11.41.3-0.81.3
Pavlov. Cond. lever contacts1.51.84.02.0-0.51.71.70.01.20.91.91.70.6-1.41.31.3-0.81.2
Pavlov. Cond. magazine entry number0.50.72.0-1.40.2-0.7-1.10.0-0.4-0.6-1.1-1.1-0.50.3-1.3-0.70.2-0.5
Pavlov. Cond. intertrial magazine entries2.53.05.2-2.3-0.9-2.1-2.1-1.2-1.6-1.9-2.1-2.3-1.7-0.5-1.7-2.0-0.7-1.6
Pavlov. Cond. lever-magazine prob. diff.1.21.44.12.0-0.61.41.5-0.20.80.61.71.60.4-1.11.41.0-0.81.3
Pavlov. Cond. response bias0.91.23.31.8-0.41.21.3-0.00.80.61.51.50.5-0.81.40.9-0.41.2
Pavlov. Cond. lever latency0.30.51.20.70.21.10.80.61.00.60.70.60.7-0.20.60.70.20.9
Pavlov. Cond. magazine entry latency0.20.20.60.60.30.60.40.10.30.60.70.70.1-0.20.10.7-0.20.4
Pavlov. Cond. change in total contacts0.10.10.60.00.5-0.0-0.00.2-0.30.60.30.50.20.8-0.10.30.50.2
Pavlov. Cond. index score0.00.00.10.20.4-0.00.0-0.0-0.20.30.20.2-0.00.30.00.20.1-0.1
Pavlov. Cond. latency score0.00.00.20.10.4-0.1-0.00.0-0.20.30.10.10.00.4-0.10.20.1-0.3
Pavlov. Cond. lever contacts0.20.30.8-0.6-0.1-0.9-0.7-0.4-0.9-0.4-0.6-0.5-0.60.2-0.5-0.5-0.0-0.7
Pavlov. Cond. magazine entry number0.00.10.1-0.1-0.2-0.10.00.20.1-0.2-0.4-0.30.30.30.3-0.30.30.1
Pavlov. Cond. intertrial magazine entries0.20.41.21.1-0.20.50.90.00.50.40.60.50.4-0.41.10.4-0.10.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.10.10.3-0.1-0.0-0.1-0.20.20.10.2-0.10.2-0.00.20.0-0.3
Pavlov. Cond. response bias0.10.10.3-0.0-0.1-0.3-0.3-0.4-0.5-0.00.10.2-0.5-0.2-0.2-0.0-0.3-0.1
Time in closed arm before self-admin0.30.41.00.40.30.60.60.70.60.70.60.91.00.40.80.70.50.7
Time in closed arm after self-admin0.10.10.5-0.2-0.00.20.20.50.20.5-0.10.10.70.3-0.20.20.20.1
Time in open arm before self-admin0.00.00.30.5-0.2-0.00.0-0.2-0.2-0.10.1-0.2-0.2-0.10.1-0.2-0.3-0.1
Time in open arm after self-admin0.10.10.50.50.7-0.1-0.0-0.2-0.1-0.4-0.0-0.0-0.20.60.5-0.10.40.1
Bone: periosteal estimation3.37.09.42.83.12.82.73.02.92.92.22.22.72.42.52.72.61.7
Bone: periosteal perimeter1.93.25.12.31.52.12.01.72.01.81.92.01.71.11.82.01.31.4
Bone: post-yield work1.42.04.21.71.21.41.61.41.91.31.31.31.10.42.11.60.91.1
Progressive ratio test 1 active lever presses0.10.10.2-0.4-0.30.1-0.2-0.3-0.2-0.4-0.3-0.50.20.1-0.2-0.3-0.1-0.3
Progressive ratio test 1 breakpoint0.00.10.2-0.4-0.30.1-0.1-0.2-0.2-0.3-0.2-0.40.30.1-0.1-0.2-0.0-0.2
Progressive ratio test 1 inactive lever presses0.60.92.0-1.4-1.0-1.2-1.0-0.7-1.0-0.8-0.7-0.9-0.7-0.6-1.2-0.6-0.7-0.8
Progressive ratio test 2 active lever presses1.01.21.9-1.0-1.3-1.0-1.0-1.4-1.2-1.2-0.7-1.2-1.1-0.8-1.1-1.1-1.1-0.8
Progressive ratio test 2 breakpoint1.21.42.1-1.1-1.3-1.0-1.1-1.5-1.4-1.3-0.8-1.3-1.3-0.8-1.2-1.3-1.1-0.8
Progressive ratio test 2 inactive lever presses0.10.10.30.4-0.00.50.3-0.00.20.10.60.20.3-0.10.10.4-0.10.5
Incentive Sensitization - Responses0.50.71.4-0.4-1.1-0.8-0.6-1.2-1.1-0.7-0.3-0.6-0.9-0.8-0.6-0.8-1.0-0.6
Incentive Sensitization - Breakpoint0.81.02.0-0.6-1.2-1.0-0.9-1.4-1.3-0.9-0.5-0.8-1.2-1.0-0.9-1.0-1.2-0.8
Sum of active levers in priming session hrs 5-60.30.30.60.50.30.30.50.50.40.60.30.60.80.40.70.40.50.6
Progressive ratio0.71.15.3-0.12.10.30.11.20.30.6-0.6-0.70.42.3-0.3-0.11.7-0.9
Food seeking constrained by brief footshock0.10.20.3-0.30.2-0.5-0.3-0.3-0.5-0.4-0.5-0.6-0.30.3-0.1-0.50.1-0.4
Seeking ratio, punishment vs. effort0.40.62.50.2-1.6-0.20.2-0.7-0.2-0.40.80.70.2-1.50.60.2-1.01.1
Retroperitoneal fat weight0.20.82.8-0.8-0.0-0.5-0.9-0.5-0.6-1.0-0.9-0.9-1.7-0.6-1.4-0.8-0.6-0.9
Reaction time number correct0.40.72.0-1.40.2-1.0-1.10.3-0.5-0.6-1.3-1.2-0.11.0-0.7-0.80.8-0.5
Reaction time mean minus median0.30.72.81.70.30.80.6-0.70.0-0.10.50.3-1.4-1.30.50.0-1.2-0.1
Reaction time mean minus median AUC0.20.62.31.2-0.00.50.3-0.9-0.1-0.20.50.3-1.3-1.50.2-0.1-1.3-0.2
Reaction time num false alarms0.40.61.40.90.11.10.90.30.60.80.91.20.8-0.10.30.7-0.01.0
Reaction time num false alarms AUC0.81.22.51.30.41.51.30.70.91.21.31.61.30.30.61.10.41.6
Reaction time trials correct on left0.40.72.0-1.40.2-1.0-1.10.3-0.5-0.6-1.3-1.2-0.11.0-0.7-0.80.8-0.5
Reaction time trials on left0.30.71.8-1.30.3-0.9-1.00.3-0.5-0.5-1.2-1.1-0.11.0-0.7-0.80.8-0.4
Reaction time mean0.81.32.91.7-0.01.11.2-0.20.90.91.71.4-0.5-1.71.11.1-0.91.3
Reaction time mean AUC0.71.22.81.60.01.01.1-0.20.80.81.61.3-0.6-1.71.01.0-0.91.2
Median of all reaction times0.91.33.21.3-0.11.01.10.11.01.11.81.5-0.0-1.41.11.3-0.61.4
Reaction time omissions0.71.02.41.50.21.11.0-0.00.80.61.51.4-0.3-1.21.01.0-0.61.3
Reaction time false alarm rate1.62.24.72.00.31.91.90.61.21.52.02.21.4-0.21.11.5-0.01.7
Reaction time premature initiation rate0.40.51.10.21.10.80.51.00.80.90.50.50.90.80.20.80.90.2
Reaction time premature initiations0.30.62.1-0.51.20.2-0.11.20.60.6-0.1-0.10.91.4-0.10.41.4-0.1
Std. dev. reaction times0.71.45.32.30.71.61.40.00.80.91.51.4-0.3-0.91.21.0-0.61.0
Reaction time trials completed0.30.71.8-1.30.3-0.9-1.00.3-0.5-0.5-1.2-1.1-0.11.0-0.7-0.80.8-0.4
Reaction time trials AUC0.30.71.9-1.40.1-1.0-1.10.3-0.5-0.5-1.2-1.1-0.20.9-0.7-0.80.7-0.5
Run reversals in cocaine runway, females0.60.61.6-1.1-0.3-0.6-0.8-0.7-0.6-0.7-0.9-0.9-0.7-0.1-0.8-0.8-0.4-1.3
Run reversals in cocaine runway, males0.40.42.11.40.80.90.70.10.50.50.70.6-0.4-0.30.50.6-0.20.4
Latency to leave start box in cocaine runway0.40.51.10.5-0.80.50.70.10.50.50.90.91.0-0.90.50.7-0.51.1
Latency to leave start box in cocaine runway, F0.20.30.90.3-0.90.10.4-0.10.20.20.70.50.6-0.90.40.4-0.60.6
Latency to leave start box in cocaine runway, M0.30.30.70.40.00.70.50.50.60.60.40.60.6-0.10.00.50.00.9
Std. dev. time between licks in bursts4.76.49.82.81.32.82.82.02.62.93.03.12.60.62.72.71.43.1
Total sessions with >9 infusions0.20.20.4-0.30.20.1-0.3-0.5-0.6-0.7-0.4-0.5-0.20.5-0.5-0.60.0-0.6
Short access day 1 total inactive lever presses0.91.22.21.41.21.41.01.00.91.01.41.10.70.50.71.10.71.5
Short access day 10 total inactive lever presses0.10.31.6-0.0-1.0-0.4-0.2-0.6-0.3-0.40.20.5-0.5-1.2-0.30.1-1.00.3
Short access day 1 total infusions0.00.10.2-0.0-0.0-0.00.3-0.4-0.2-0.4-0.0-0.30.30.20.1-0.1-0.1-0.4
Short access day 10 total infusions0.60.81.4-0.8-0.5-0.4-0.9-1.0-1.0-1.1-0.9-1.1-1.1-0.4-1.2-0.9-0.7-0.7
Short access total infusions0.20.20.6-0.5-0.1-0.1-0.4-0.6-0.6-0.8-0.4-0.7-0.40.1-0.7-0.6-0.2-0.4
Short access day 1 locomotion0.50.61.8-0.4-1.3-0.4-0.2-1.3-0.5-1.00.0-0.4-0.5-1.3-0.2-0.5-1.3-0.3
Short access day 10 total locomotion1.73.25.01.51.81.81.71.81.81.81.71.42.21.72.01.81.91.7
Short access total locomotion0.60.71.40.60.50.90.90.50.90.51.10.81.00.41.00.90.61.2
One hour access (0.3 mA shock)1.51.84.5-0.6-2.1-0.9-0.8-1.9-1.3-1.2-0.5-0.8-1.5-2.0-1.0-1.0-2.0-0.6
Compulsive drug intake1.11.33.80.8-1.50.51.1-0.60.90.51.51.60.7-2.01.31.0-1.21.1
One hour access (shock baseline)1.62.44.9-1.2-0.4-1.2-1.7-1.4-1.9-1.5-1.7-2.1-2.2-0.3-1.9-1.8-0.9-1.7
Social response proportion2.22.54.41.31.41.21.61.81.71.71.31.22.11.61.81.51.81.0
Social responses1.62.04.21.11.31.21.41.61.41.41.11.22.01.71.31.21.71.1
Social time1.82.55.12.30.52.02.00.51.51.62.22.10.9-0.71.61.7-0.21.6
Soleus weight4.513.320.73.92.04.04.23.04.33.84.34.53.80.74.04.41.93.4
Bone: stiffness0.30.51.1-0.80.1-0.5-0.9-0.1-0.4-0.7-1.1-1.0-0.70.1-1.0-0.7-0.1-1.0
Tibialis anterior weight0.41.32.5-1.5-0.3-1.1-1.4-0.7-1.2-1.1-1.6-1.4-0.90.1-1.4-1.3-0.3-1.3
Time to tail flick, vehicle, before self-admin1.11.13.6-0.5-1.3-0.6-0.7-1.3-0.8-0.9-0.4-0.4-1.6-1.9-0.7-0.8-1.6-0.6
Time to tail flick, vehicle, after self-admin0.20.20.50.7-0.20.40.6-0.30.30.20.60.60.0-0.60.70.4-0.40.4
Time to tail flick, test, before self-admin0.60.61.2-0.3-0.4-0.5-0.7-0.9-1.0-0.9-0.8-1.0-1.1-0.4-0.7-1.0-0.8-0.9
Time to tail flick, test, after self-admin1.61.74.8-0.3-0.9-1.1-1.0-1.6-1.5-0.9-1.0-1.1-2.2-1.4-1.2-1.5-1.6-1.1
Delta time to tail flick, vehicle, before/after SA0.20.10.3-0.3-0.4-0.5-0.3-0.5-0.5-0.4-0.4-0.3-0.3-0.1-0.3-0.4-0.4-0.2
Delta time to tail flick, test, before/after SA0.80.81.2-1.0-1.0-1.0-0.9-0.9-0.8-0.6-0.7-0.6-1.1-1.1-0.9-0.7-1.0-0.7
Tibia length3.08.213.02.83.63.13.03.53.42.92.12.02.82.62.72.73.12.2
Ambulatory time before self-admin0.00.10.30.20.20.20.0-0.40.0-0.10.10.1-0.6-0.3-0.00.1-0.3-0.3
Ambulatory time after self-admin1.21.43.51.11.91.00.91.30.81.20.71.01.01.70.90.91.60.7
Bone: tissue strength0.20.20.6-0.10.70.5-0.10.30.20.1-0.3-0.4-0.20.3-0.80.00.2-0.7
Total heroin consumption0.10.10.30.60.30.40.40.10.30.40.20.40.20.20.40.20.1-0.2
Bone: trabecular number3.55.99.8-2.4-2.7-2.3-2.6-2.7-2.5-2.5-2.0-1.8-3.1-2.6-2.5-2.4-2.5-1.2
Bone: trabecular spacing3.85.07.62.22.72.42.22.62.42.21.81.52.82.51.92.22.51.3
Bone: trabecular thickness2.73.46.1-1.9-1.9-1.9-2.1-1.9-1.9-1.8-1.7-1.6-2.5-1.9-1.8-1.9-1.7-0.8
Bone: trabecular tissue density0.30.41.00.70.60.90.60.60.20.70.40.50.81.00.00.40.60.5
Water consumed over 24 hours0.20.30.70.60.30.70.60.40.70.60.60.60.80.10.60.60.20.5
Number of responses in last shaping day3.84.111.01.91.42.32.31.82.02.01.91.73.31.82.12.01.71.6