Hub : Genes

LOC108352599

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc gene expression LOC108352599 0.04 0.03 4.5e-04 0.02 0.01 0.01 0.01 9.7e-04 2.9e-03 8.9e-03 8.9e-03
2 Brain mRNA stability LOC108352599 0.03 0.02 5.9e-03 0.01 0.01 0 0 6.1e-02 2.5e-02 3.5e-01 1.5e-01
3 Adipose gene expression LOC108352599 0.04 0.03 4.1e-05 0.04 0.04 0.03 0.03 5.3e-05 8.3e-05 1.1e-04 1.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density0.61.01.21.1-0.9-1.0
Area under the delay curve0.10.10.10.3-0.2-0.3
BMI with tail0.10.40.50.7-0.7-0.3
BMI without tail1.23.75.32.3-2.3-0.8
Body weight3.414.921.64.6-4.6-1.5
Weight adjusted by age2.23.44.42.1-2.0-1.4
Bone surface0.61.11.31.1-1.0-1.1
Bone volume0.61.11.61.2-1.1-0.8
Breakpoint value in progressive ratio session0.70.81.70.9-1.3-0.1
Number of licking bursts0.71.12.40.8-0.5-1.6
Context. condit. distance diff. score1.62.02.21.5-1.3-1.5
Locomotion velocity, session 10.30.30.9-0.0-0.1-0.9
Locomotion distance, session 12.12.62.91.7-1.5-1.7
Locomotion velocity, session 20.30.30.30.6-0.5-0.6
Locomotion distance, session 20.10.10.10.3-0.3-0.1
Locomotion velocity, session 31.51.72.51.6-1.60.1
Locomotion distance, session 30.60.61.60.5-0.31.3
Stereotopy head waving bouts, day 30.70.82.3-0.30.0-1.5
Stereotopy head waving duration, day 31.11.34.0-0.1-0.1-2.0
Locomotion velocity, session 71.31.43.9-0.30.32.0
Locomotion distance, session 71.72.15.0-0.70.92.2
Stereotopy head waving bouts, day 71.61.83.50.9-1.1-1.9
Stereotopy head waving duration, day 72.12.55.80.8-1.0-2.4
Locomotion velocity, session 80.91.13.00.3-0.3-1.7
Locomotion distance, session 81.42.12.31.5-1.3-1.5
Degree of sensitization distance0.50.60.9-1.00.90.2
Degree of sensitization stereotypy0.50.50.80.5-0.6-0.9
Conditioned locomotion0.80.91.3-1.11.1-0.2
Cocaine response after cond. corrected0.30.30.4-0.60.6-0.5
Cocaine response after cond. not corrected0.60.71.9-0.20.3-1.4
Cocaine response before conditioning1.01.21.61.1-0.9-1.2
Saline control response0.50.71.41.2-0.7-0.4
Bone: connectivity density1.52.44.11.3-1.1-2.0
Bone: cortical apparent density0.30.40.8-0.60.40.9
Bone: cortical area1.72.63.71.9-1.8-0.9
Bone: cortical porosity0.50.61.7-0.10.2-1.3
Bone: cortical porosity0.40.51.3-0.10.2-1.1
Bone: cortical thickness0.61.01.31.0-0.9-1.1
Bone: cortical thickness2.32.72.81.7-1.6-1.7
Bone: cortical tissue density0.40.60.9-0.70.51.0
Condit. Reinf. active minus inactive responses0.30.30.40.6-0.40.7
Condit. Reinf. active-inactive response ratio0.10.10.2-0.20.50.3
Condit. Reinf. active responses1.31.62.31.5-1.40.7
Condit. Reinf. inactive responses1.92.33.51.9-1.8-0.2
Incentive salience index mean0.91.11.31.2-1.00.9
Condit. Reinf. lever presses1.72.43.31.8-1.80.7
Condit. Reinf. active minus inactive responses0.10.10.3-0.20.40.5
Condit. Reinf. active-inactive response ratio0.91.11.5-1.21.20.6
Condit. Reinf. active responses0.20.30.70.2-0.10.8
Condit. Reinf. inactive responses1.82.33.71.9-1.80.3
Condit. Reinf. lever presses0.30.50.60.8-0.80.4
Condit. Reinf. lever reinforcers received0.20.20.60.2-0.20.8
Conditioned reinforcement - actives0.61.01.31.0-0.9-1.1
Conditioned reinforcement - inactives1.62.42.81.5-1.7-1.4
Conditioned locomotion2.83.74.21.9-1.8-2.0
Patch foraging indifference point 0 sec1.62.93.91.7-1.3-2.0
Patch foraging indifference point AUC1.11.61.6-1.21.31.3
Delay disc. indifference point, 0s delay0.10.10.20.1-0.4-0.4
Delay disc. indifference point, 16s delay0.20.20.30.5-0.2-0.5
Delay disc. indifference point, 2s delay0.30.30.40.6-0.3-0.6
Delay disc. indifference point, 24s delay0.10.10.30.5-0.1-0.0
Delay disc. indifference point, 4s delay0.50.50.70.8-0.90.2
Delay disc. indifference point, 8s delay0.40.40.7-0.90.80.1
Indifference point function ln k1.01.73.90.8-0.8-2.0
Indifference point function log k1.01.73.90.8-0.8-2.0
Patch foraging total patch changes 0 sec1.63.03.91.8-1.4-2.0
Patch foraging total patch changes 12 sec0.81.01.51.2-1.0-0.7
Patch foraging total patch changes 18 sec0.20.20.40.7-0.50.1
Patch foraging total patch changes 24 sec0.30.40.80.9-0.70.3
Patch foraging total patch changes 6 sec0.40.61.31.1-0.7-0.1
Patch foraging time to switch 0 sec0.40.81.50.9-1.20.1
Patch foraging water rate 0 sec0.51.02.1-0.50.8-1.4
Patch foraging water rate 12 sec0.71.52.3-1.51.40.2
Patch foraging water rate 18 sec0.10.10.2-0.50.3-0.2
Patch foraging water rate 24 sec0.10.20.2-0.40.4-0.5
Patch foraging water rate 6 sec0.20.30.80.00.2-0.9
Seeking ratio, delayed vs. immediate footshock0.10.20.40.3-0.00.6
Distance traveled before self-admin3.54.67.71.9-1.6-2.8
Distance traveled after self-admin1.82.23.71.1-1.3-1.9
Extensor digitorum longus weight0.31.13.10.1-0.51.8
Bone: elastic displacement0.91.02.9-0.20.2-1.7
Bone: elastic work0.70.92.60.2-0.2-1.6
Bone: endosteal estimation0.10.10.20.4-0.30.3
Bone: endosteal perimeter0.40.91.41.2-1.00.6
Epididymis fat weight0.82.84.51.3-1.4-2.1
Delta time in closed arm before/after self-admin0.40.40.7-0.80.50.6
Delta time in open arm before/after self-admin1.41.42.21.5-1.20.7
Diff in mean of infusions in LGA sessions0.60.80.90.9-0.9-0.8
Delay discount exponential model param0.10.10.2-0.50.30.3
Extinction: sum of active levers before priming3.23.55.72.2-2.4-0.3
Active lever presses in extinction session 64.44.47.02.2-2.6-1.1
Bone: final force0.71.11.21.0-1.1-1.1
Bone: final moment0.71.11.51.1-1.2-0.8
Food consumed during 24 hour testing period0.30.40.80.5-0.4-0.9
Glucose0.30.50.7-0.50.8-0.6
Heart weight0.71.11.81.3-1.3-0.1
Delay discount hyperbolic model param0.20.20.4-0.70.40.3
Intermittent access intake day 1-15 change1.12.34.1-2.01.6-0.1
Intermittent access intake escalation1.22.44.2-2.01.7-0.3
Intermittent access intake escalation 21.41.52.6-1.61.4-0.3
Intermitt. access day 1 inactive lever presses0.00.10.30.0-0.20.5
Intermitt. access day 15 inactive lever presses0.10.30.40.4-0.60.6
Intermitt. access escalation Index0.30.41.0-0.50.31.0
Intermittent access day 1 total infusions1.52.43.41.8-1.8-0.8
Intermittent access day 15 total infusions0.40.71.7-0.50.3-1.3
Intermittent access terminal intake (last 3 days)0.20.20.4-0.60.3-0.4
Intermittent access total infusions0.40.51.20.3-0.4-1.1
Intermittent access day 1 locomotion2.63.34.32.0-2.1-1.3
Intermittent access day 15 total locomotion1.22.23.31.2-1.3-1.8
Intermittent access total locomotion2.53.03.21.8-1.7-1.7
Intermittent access standard deviation0.30.61.1-1.00.70.5
Left kidney weight1.78.010.43.2-3.2-1.8
Right kidney weight1.88.411.33.2-3.4-2.0
Cocaine induced anxiety0.71.01.90.6-0.91.4
Post-drug Anxiety0.30.30.9-0.30.11.0
Baseline Anxiety2.63.04.2-1.92.0-1.1
Tail length3.011.617.24.1-4.1-0.8
Length with tail4.519.628.95.3-5.4-1.4
Length without tail2.16.89.42.9-3.1-1.6
Times rat made contact with spout0.10.10.30.2-0.4-0.5
Lifetime Intake0.60.71.40.6-0.7-1.2
Liver weight, left0.50.81.01.0-1.0-0.8
Liver weight, right0.71.12.80.6-0.5-1.7
Locomotor activity0.10.20.4-0.2-0.1-0.6
Locomotor testing distance0.00.00.1-0.1-0.3-0.2
Locomotor testing rearing0.10.10.2-0.40.30.3
Locomotion in novel chamber0.30.40.5-0.60.50.7
Locomotion in novel chamber post-restriction0.00.00.00.00.2-0.2
Fecal boli incidents, locomotor time 10.10.10.2-0.40.30.2
Change in fecal boli incidents, locomotor task0.10.10.2-0.40.3-0.2
Time >=10cm from walls, locomotor time 10.00.00.1-0.1-0.0-0.4
Bouts of movement, locomotor time 10.50.60.7-0.90.7-0.6
Total resting periods, locomotor time 10.40.40.6-0.80.7-0.3
Rest time, locomotor task time 10.91.11.8-1.31.2-0.2
Distance moved, locomotor task time 10.60.91.51.0-1.2-0.4
Vertical activity count, locomotor time 10.20.50.80.6-0.5-0.9
Time >=10cm from walls, locomotor time 20.50.71.11.0-1.00.5
Bouts of movement, locomotor time 20.00.10.1-0.20.4-0.0
Total resting periods, locomotor time 20.00.00.0-0.00.2-0.0
Rest time, locomotor task time 21.51.92.9-1.71.50.6
Distance moved, locomotor task time 22.22.73.91.7-2.0-1.2
Vertical activity count, locomotor time 20.50.70.80.8-0.7-0.9
Light reinforcement 10.30.71.2-0.60.6-1.1
Light reinforcement 20.71.12.4-0.70.5-1.6
Bone: marrow area0.00.10.10.4-0.20.3
Bone: maximum diameter0.61.11.91.4-1.2-0.2
Bone: maximum force1.32.33.21.4-1.3-1.8
Bone: maximum moment1.32.32.51.5-1.5-1.6
Mean time between licks in bursts0.30.61.8-0.20.11.4
Mean num. licks in bursts0.50.81.9-0.70.31.4
Cd content in liver8.39.213.93.7-3.6-0.9
Co content in liver0.91.13.10.3-0.3-1.7
Cu content in liver4.45.27.2-2.72.51.5
Fe content in liver3.34.04.8-2.22.21.5
K content in liver1.21.21.6-1.31.20.8
Mg content in liver0.50.51.20.4-0.4-1.1
Mn content in liver0.20.20.30.6-0.5-0.2
Na content in liver2.93.14.1-2.01.91.2
Rb content in liver1.82.02.7-1.61.41.2
Se content in liver0.40.50.90.6-0.5-1.0
Sr content in liver0.70.61.80.2-0.11.3
Zn content in liver6.57.29.42.5-2.4-3.1
Bone: minimum diameter0.71.21.41.2-1.01.1
Time in familiar zone, hab. session 11.01.02.5-0.40.41.6
Time in novel zone, hab. session 11.21.21.71.0-1.3-0.8
Total zone transitions, hab. session 11.31.82.31.5-1.5-0.9
Total locomotion distance, hab. session 10.71.01.40.8-0.9-1.2
Locomotion velocity, hab. session 10.81.12.30.7-0.7-1.5
Time in familiar zone, hab. session 20.20.20.40.6-0.50.1
Time in novel zone, hab. session 20.10.10.30.4-0.50.1
Total zone transitions, hab. session 21.82.43.41.9-1.7-0.9
Total locomotion distance, hab. session 21.11.52.01.4-1.3-0.9
Locomotion velocity, hab. session 20.91.21.51.2-1.0-1.0
Novel to familiar place preference ratio0.00.10.10.1-0.2-0.3
Novelty place preference0.10.10.20.3-0.4-0.4
Time in novel zone, NPP test0.10.10.20.3-0.5-0.3
Total zone transitions, NPP test2.63.84.42.1-2.0-1.7
Total locomotion distance, NPP test1.42.02.51.6-1.4-1.2
Locomotion velocity, NPP test1.41.92.51.6-1.4-1.2
Intraocular pressure0.10.20.4-0.10.3-0.6
Delta distance traveled before/after self-admin0.40.40.9-0.50.10.9
Delta ambulatory time before/after self-admin0.20.30.4-0.60.40.6
Parametrial fat weight0.20.51.30.2-0.61.1
Pavlov. Cond. lever latency2.53.25.1-2.32.1-0.2
Pavlov. Cond. magazine entry latency2.53.24.22.0-2.11.2
Pavlov. Cond. change in total contacts2.72.94.72.2-2.00.4
Pavlov. Cond. index score1.82.32.91.7-1.71.1
Pavlov. Cond. latency score2.22.73.81.9-1.81.0
Pavlov. Cond. lever contacts1.41.72.51.6-1.50.4
Pavlov. Cond. magazine entry number2.02.63.1-1.61.8-1.4
Pavlov. Cond. intertrial magazine entries0.40.51.50.10.2-1.2
Pavlov. Cond. lever-magazine prob. diff.1.92.43.31.8-1.80.9
Pavlov. Cond. response bias2.22.73.81.8-1.91.0
Pavlov. Cond. lever latency0.91.21.8-1.31.40.2
Pavlov. Cond. magazine entry latency1.21.52.01.3-1.4-0.8
Pavlov. Cond. change in total contacts0.20.40.5-0.70.40.6
Pavlov. Cond. index score1.11.52.31.4-1.5-0.5
Pavlov. Cond. latency score1.01.32.11.3-1.5-0.4
Pavlov. Cond. lever contacts0.71.01.41.2-1.2-0.2
Pavlov. Cond. magazine entry number0.40.50.8-0.70.90.6
Pavlov. Cond. intertrial magazine entries0.10.10.30.30.00.5
Pavlov. Cond. lever-magazine prob. diff.0.91.21.81.2-1.3-0.6
Pavlov. Cond. response bias1.21.62.51.5-1.6-0.4
Time in closed arm before self-admin0.10.10.30.10.2-0.5
Time in closed arm after self-admin0.80.81.4-1.20.9-0.5
Time in open arm before self-admin0.30.30.60.6-0.8-0.2
Time in open arm after self-admin1.41.51.91.4-1.31.0
Bone: periosteal estimation0.71.42.31.5-1.4-0.3
Bone: periosteal perimeter1.01.82.91.7-1.5-0.3
Bone: post-yield work0.10.10.2-0.00.2-0.4
Progressive ratio test 1 active lever presses0.60.81.31.0-1.10.1
Progressive ratio test 1 breakpoint0.60.71.21.0-1.10.0
Progressive ratio test 1 inactive lever presses0.71.01.70.9-1.30.6
Progressive ratio test 2 active lever presses0.10.10.30.3-0.50.0
Progressive ratio test 2 breakpoint0.10.10.20.2-0.4-0.0
Progressive ratio test 2 inactive lever presses1.42.33.21.4-1.8-1.3
Incentive Sensitization - Responses0.00.10.20.1-0.4-0.2
Incentive Sensitization - Breakpoint0.00.00.10.0-0.3-0.0
Sum of active levers in priming session hrs 5-64.64.36.32.4-2.5-0.8
Progressive ratio3.96.013.01.9-1.3-3.6
Food seeking constrained by brief footshock0.50.60.9-0.60.70.9
Seeking ratio, punishment vs. effort3.34.810.4-1.61.23.2
Retroperitoneal fat weight1.66.88.92.9-3.0-1.8
Reaction time number correct0.00.10.10.30.10.3
Reaction time mean minus median0.51.21.6-1.01.0-1.3
Reaction time mean minus median AUC0.51.31.9-1.41.4-0.5
Reaction time num false alarms2.94.15.5-2.22.31.5
Reaction time num false alarms AUC2.43.75.0-2.12.21.2
Reaction time trials correct on left0.00.10.10.30.10.3
Reaction time trials on left0.00.00.10.30.10.2
Reaction time mean0.50.80.9-1.00.9-0.9
Reaction time mean AUC0.71.11.4-1.21.1-0.9
Median of all reaction times0.40.50.8-0.90.8-0.4
Reaction time omissions1.11.64.70.10.2-2.2
Reaction time false alarm rate1.62.23.0-1.71.60.9
Reaction time premature initiation rate0.30.40.8-0.50.10.9
Reaction time premature initiations0.20.40.8-0.50.30.9
Std. dev. reaction times0.91.63.8-0.80.7-2.0
Reaction time trials completed0.00.00.10.30.10.2
Reaction time trials AUC0.00.10.10.30.10.3
Run reversals in cocaine runway, females0.60.61.0-0.80.51.0
Run reversals in cocaine runway, males0.50.51.1-1.00.70.0
Latency to leave start box in cocaine runway1.11.22.0-1.21.40.6
Latency to leave start box in cocaine runway, F0.50.50.9-0.81.0-0.2
Latency to leave start box in cocaine runway, M0.90.91.1-0.80.91.1
Std. dev. time between licks in bursts0.30.40.60.6-0.50.8
Total sessions with >9 infusions1.31.62.31.5-1.5-0.6
Short access day 1 total inactive lever presses0.40.50.80.6-0.9-0.4
Short access day 10 total inactive lever presses0.30.71.90.1-0.41.4
Short access day 1 total infusions0.70.91.41.0-1.2-0.4
Short access day 10 total infusions1.01.31.81.3-1.2-0.9
Short access total infusions1.41.82.01.4-1.4-1.3
Short access day 1 locomotion2.53.14.32.1-1.9-1.2
Short access day 10 total locomotion0.00.00.00.1-0.0-0.1
Short access total locomotion1.11.31.61.3-1.2-1.0
One hour access (0.3 mA shock)0.30.30.60.6-0.8-0.2
Compulsive drug intake1.01.23.4-0.40.01.8
One hour access (shock baseline)0.50.72.00.3-0.2-1.4
Social response proportion0.00.00.10.10.20.2
Social responses0.20.20.50.7-0.00.3
Social time0.00.00.00.10.20.0
Soleus weight0.72.13.0-1.11.5-1.7
Bone: stiffness0.91.51.91.3-1.4-0.9
Tibialis anterior weight0.31.11.90.7-0.91.4
Time to tail flick, vehicle, before self-admin0.50.51.0-1.00.80.1
Time to tail flick, vehicle, after self-admin0.81.11.31.1-1.2-0.9
Time to tail flick, test, before self-admin1.31.43.90.3-0.4-2.0
Time to tail flick, test, after self-admin1.01.11.70.8-0.9-1.3
Delta time to tail flick, vehicle, before/after SA1.41.31.81.3-1.3-0.7
Delta time to tail flick, test, before/after SA0.30.30.60.8-0.60.1
Tibia length0.82.33.91.8-2.00.2
Ambulatory time before self-admin2.43.77.11.6-1.2-2.7
Ambulatory time after self-admin0.70.92.50.3-0.2-1.6
Bone: tissue strength0.20.20.5-0.70.20.1
Total heroin consumption4.24.96.82.5-2.6-1.2
Bone: trabecular number0.30.51.30.5-0.2-1.1
Bone: trabecular spacing0.40.51.00.5-1.00.4
Bone: trabecular thickness0.00.00.0-0.00.1-0.1
Bone: trabecular tissue density1.11.63.1-1.10.81.8
Water consumed over 24 hours0.20.20.60.3-0.3-0.8
Number of responses in last shaping day0.10.10.2-0.20.4-0.5