Hub : Genes

LOC108352416

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC108352416	0.04	0.02	9.5e-04	0.01	0.01	0.02	0.01	7.3e-02	2.7e-02	1.8e-02	8.5e-02
2	Liver	intron excision ratio	chr12_11296407_11297136	0.32	0.1	0.0e+00	0.25	0.24	0.23	0.24	4.8e-27	1.4e-26	1.3e-25	3.2e-26
3	Liver	intron excision ratio	chr12_11296407_11300825	0.3	0.11	0.0e+00	0.23	0.22	0.22	0.22	1.1e-24	3.7e-24	7.9e-24	5.7e-24
4	Liver	gene expression	LOC108352416	0.68	0.13	0.0e+00	0.32	0.3	0.31	0.31	4.7e-36	5.1e-33	1.7e-34	5.2e-35
5	Liver	intron excision ratio	chr12_11297183_11300825	0.11	0.06	1.6e-12	0.08	0.08	0.08	0.07	1.7e-09	2.8e-09	5.6e-09	2.8e-08
6	Liver	intron excision ratio	chr12_11275598_11296340	0.15	0.06	0.0e+00	0.13	0.12	0.12	0.12	1.9e-14	4.4e-13	8.6e-13	2.3e-13

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.0	1.9	2.8	1.3	-1.4	1.3	1.2	1.2	1.7
Area under the delay curve	0.2	0.3	0.6	-0.7	0.5	-0.7	-0.6	-0.5	-0.5
BMI with tail	1.2	4.4	5.5	2.2	-2.1	2.3	1.9	1.8	2.1
BMI without tail	0.4	2.4	3.6	-1.5	1.7	-1.4	-1.6	-1.9	-1.1
Body weight	0.2	0.8	3.9	-2.0	0.1	0.1	-0.6	-0.7	-0.4
Weight adjusted by age	0.1	0.3	0.6	-0.8	-0.4	0.5	0.5	0.6	0.3
Bone surface	0.3	0.5	0.9	0.5	-0.9	0.9	0.5	0.5	0.8
Bone volume	1.2	2.5	2.9	1.6	-1.6	1.6	1.4	1.4	1.7
Breakpoint value in progressive ratio session	1.6	2.9	5.0	-1.5	1.7	-1.6	-1.6	-1.6	-2.2
Number of licking bursts	0.2	0.6	1.8	-1.3	0.3	-0.3	-0.4	-0.4	-1.0
Context. condit. distance diff. score	0.1	0.1	0.3	-0.1	-0.3	0.5	0.5	0.5	0.1
Locomotion velocity, session 1	0.4	0.4	1.0	-1.0	0.8	-0.6	-0.4	-0.3	0.3
Locomotion distance, session 1	0.1	0.2	0.4	-0.5	0.6	-0.5	-0.3	-0.3	-0.1
Locomotion velocity, session 2	0.1	0.1	0.7	-0.8	-0.0	-0.2	-0.2	-0.3	0.0
Locomotion distance, session 2	1.8	2.5	3.6	-1.9	1.5	-1.6	-1.5	-1.7	-1.2
Locomotion velocity, session 3	0.3	0.4	0.6	-0.2	-0.7	0.6	0.8	0.7	0.5
Locomotion distance, session 3	1.4	1.6	2.3	-1.4	1.2	-1.2	-1.1	-1.2	-1.5
Stereotopy head waving bouts, day 3	0.2	0.3	0.9	-0.9	-0.7	0.4	0.3	0.3	-0.0
Stereotopy head waving duration, day 3	1.1	1.3	1.7	0.3	-1.3	1.3	1.3	1.3	1.1
Locomotion velocity, session 7	0.0	0.0	0.0	0.2	-0.0	0.0	0.0	-0.0	0.2
Locomotion distance, session 7	0.3	0.4	0.6	0.1	0.7	-0.7	-0.7	-0.8	-0.2
Stereotopy head waving bouts, day 7	3.7	4.2	4.9	-2.2	2.0	-2.1	-1.9	-1.9	-2.2
Stereotopy head waving duration, day 7	0.8	1.0	1.9	-1.4	1.0	-0.9	-0.8	-0.8	-1.1
Locomotion velocity, session 8	0.4	0.5	1.6	-1.3	0.4	-0.6	-0.6	-0.7	-0.2
Locomotion distance, session 8	0.4	0.5	1.5	-1.2	0.8	-0.6	-0.5	-0.6	-0.4
Degree of sensitization distance	0.3	0.3	1.1	1.1	-0.3	0.2	0.1	0.1	0.9
Degree of sensitization stereotypy	1.1	1.2	1.5	-1.0	1.2	-1.1	-1.0	-1.0	-1.2
Conditioned locomotion	0.1	0.1	0.2	0.3	-0.4	0.2	0.4	0.5	0.1
Cocaine response after cond. corrected	0.5	0.8	2.3	1.5	-0.6	0.6	0.6	0.6	1.0
Cocaine response after cond. not corrected	0.5	0.7	2.1	1.5	-0.6	0.5	0.5	0.6	0.8
Cocaine response before conditioning	0.3	0.4	0.8	-0.6	0.6	-0.5	-0.5	-0.5	-0.9
Saline control response	3.7	5.2	8.4	-2.9	2.9	-2.2	-1.8	-1.8	-1.7
Bone: connectivity density	0.0	0.0	0.2	-0.1	-0.4	0.2	0.0	-0.0	0.2
Bone: cortical apparent density	1.1	1.7	3.2	1.8	-0.7	1.0	1.2	1.1	1.7
Bone: cortical area	0.0	0.0	0.1	-0.2	0.1	0.2	0.2	0.2	0.2
Bone: cortical porosity	0.2	0.3	0.9	-0.9	0.3	-0.2	0.0	0.0	-0.8
Bone: cortical porosity	0.2	0.3	0.9	-1.0	0.4	-0.2	0.1	0.1	-0.6
Bone: cortical thickness	0.3	0.4	0.6	0.7	-0.0	0.5	0.8	0.7	0.8
Bone: cortical thickness	1.2	1.5	3.8	-0.5	2.0	-1.4	-1.1	-1.1	-0.7
Bone: cortical tissue density	1.2	1.9	3.4	1.8	-0.8	1.0	1.3	1.2	1.8
Condit. Reinf. active minus inactive responses	1.7	1.9	2.5	1.0	-1.3	1.4	1.5	1.4	1.6
Condit. Reinf. active-inactive response ratio	4.5	4.9	6.5	2.2	-2.1	2.1	2.2	2.0	2.6
Condit. Reinf. active responses	0.5	0.6	0.8	0.4	-0.8	0.8	0.9	0.7	0.9
Condit. Reinf. inactive responses	0.3	0.4	0.9	-0.9	0.4	-0.5	-0.5	-0.5	-0.7
Incentive salience index mean	0.1	0.1	0.1	0.2	-0.3	0.3	0.3	0.2	0.3
Condit. Reinf. lever presses	0.0	0.0	0.1	0.3	-0.1	0.0	0.1	-0.0	0.1
Condit. Reinf. active minus inactive responses	1.0	1.5	2.6	-1.6	1.3	-1.2	-1.2	-1.1	-0.8
Condit. Reinf. active-inactive response ratio	1.0	1.6	2.9	-1.7	1.4	-1.2	-1.1	-1.1	-0.9
Condit. Reinf. active responses	1.6	2.3	3.7	-1.9	1.5	-1.5	-1.5	-1.5	-1.0
Condit. Reinf. inactive responses	0.6	0.9	1.2	-0.9	0.9	-1.0	-1.1	-1.1	-0.4
Condit. Reinf. lever presses	0.6	0.8	1.2	-0.6	1.1	-0.9	-0.9	-0.9	-1.0
Condit. Reinf. lever reinforcers received	1.8	2.5	3.6	-1.9	1.5	-1.6	-1.6	-1.6	-1.2
Conditioned reinforcement - actives	0.2	0.9	2.4	-1.6	0.8	-0.7	-0.7	-0.7	-0.9
Conditioned reinforcement - inactives	0.1	0.2	0.3	-0.6	0.4	-0.2	-0.3	-0.3	-0.5
Conditioned locomotion	0.9	1.3	2.0	-1.4	1.1	-0.9	-1.0	-1.0	-1.3
Patch foraging indifference point 0 sec	0.1	0.3	0.6	-0.1	-0.6	0.8	0.5	0.5	0.3
Patch foraging indifference point AUC	0.0	0.0	0.1	0.0	-0.1	0.2	0.2	0.2	0.3
Delay disc. indifference point, 0s delay	0.1	0.1	0.5	-0.7	0.1	-0.4	-0.1	-0.1	0.3
Delay disc. indifference point, 16s delay	0.0	0.0	0.1	-0.3	-0.2	0.2	0.2	0.2	0.2
Delay disc. indifference point, 2s delay	1.7	1.9	2.7	-0.6	1.6	-1.7	-1.5	-1.4	-1.3
Delay disc. indifference point, 24s delay	0.1	0.1	0.5	-0.7	-0.3	0.1	0.2	0.1	-0.3
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	0.2	-0.4	0.2	0.3	0.3	0.1
Delay disc. indifference point, 8s delay	0.1	0.2	0.2	-0.5	0.3	-0.5	-0.5	-0.4	-0.2
Indifference point function ln k	0.2	0.6	1.4	-1.2	0.6	-0.8	-0.5	-0.5	-1.0
Indifference point function log k	0.2	0.6	1.4	-1.2	0.6	-0.8	-0.5	-0.5	-1.0
Patch foraging total patch changes 0 sec	0.1	0.2	0.3	-0.2	-0.5	0.6	0.5	0.5	0.1
Patch foraging total patch changes 12 sec	0.8	1.0	2.1	0.4	-0.9	1.5	1.1	1.1	0.8
Patch foraging total patch changes 18 sec	1.3	3.1	4.0	1.3	-1.9	2.0	1.8	1.8	1.8
Patch foraging total patch changes 24 sec	0.0	0.1	0.2	-0.1	-0.3	0.5	0.3	0.3	0.2
Patch foraging total patch changes 6 sec	0.1	0.1	0.3	-0.5	0.3	-0.2	-0.3	-0.2	-0.4
Patch foraging time to switch 0 sec	0.2	0.8	1.7	1.3	-0.9	1.3	0.3	0.3	0.6
Patch foraging water rate 0 sec	0.0	0.1	0.4	-0.4	0.3	-0.7	0.0	0.1	0.2
Patch foraging water rate 12 sec	0.1	0.6	1.9	-1.4	0.3	-0.7	-0.5	-0.5	-0.6
Patch foraging water rate 18 sec	0.4	1.0	2.2	-1.2	0.9	-1.5	-0.6	-0.5	-0.9
Patch foraging water rate 24 sec	1.0	1.4	2.6	-1.0	1.4	-1.6	-1.1	-1.3	-0.2
Patch foraging water rate 6 sec	0.4	0.6	1.0	0.2	-0.7	0.5	0.9	1.0	1.0
Seeking ratio, delayed vs. immediate footshock	0.8	1.1	1.5	-0.7	1.0	-0.9	-1.2	-1.2	-1.2
Distance traveled before self-admin	1.5	3.2	3.8	1.9	-1.8	1.9	1.8	1.9	1.3
Distance traveled after self-admin	0.3	0.6	0.9	0.4	-0.8	0.9	0.9	0.9	0.5
Extensor digitorum longus weight	0.2	0.8	2.0	-0.3	-1.0	1.0	0.6	0.7	1.4
Bone: elastic displacement	0.0	0.0	0.1	0.1	0.3	-0.0	0.2	0.2	0.1
Bone: elastic work	1.1	1.4	2.0	-1.1	1.4	-1.2	-1.1	-1.1	-1.3
Bone: endosteal estimation	0.9	2.1	3.8	-1.9	0.8	-1.3	-1.6	-1.6	-1.2
Bone: endosteal perimeter	0.3	0.8	2.4	-1.5	0.2	-0.6	-1.0	-0.9	-0.7
Epididymis fat weight	0.9	4.5	5.2	1.8	-2.1	2.2	2.3	2.3	1.9
Delta time in closed arm before/after self-admin	0.3	0.3	0.6	-0.7	0.3	-0.4	-0.2	-0.2	-0.8
Delta time in open arm before/after self-admin	0.1	0.1	0.2	-0.3	0.5	-0.1	-0.4	-0.4	0.1
Diff in mean of infusions in LGA sessions	0.1	0.2	1.0	-0.3	-0.2	0.2	0.1	0.1	-1.0
Delay discount exponential model param	0.2	0.3	0.4	0.6	-0.4	0.6	0.5	0.5	0.6
Extinction: sum of active levers before priming	0.2	0.4	0.6	0.7	-0.5	0.7	0.8	0.6	-0.3
Active lever presses in extinction session 6	0.2	0.2	0.4	0.2	-0.4	0.4	0.7	0.6	-0.5
Bone: final force	0.5	0.8	1.2	-1.1	1.0	-0.8	-0.7	-0.8	-1.1
Bone: final moment	0.3	0.5	0.8	-0.8	0.9	-0.6	-0.5	-0.6	-0.8
Food consumed during 24 hour testing period	0.5	1.0	1.6	-1.3	1.0	-0.9	-0.9	-0.8	-1.0
Glucose	0.2	0.4	0.7	0.1	-0.8	0.9	0.6	0.7	0.1
Heart weight	0.8	1.2	2.4	-0.8	1.2	-1.6	-1.1	-1.1	-0.7
Delay discount hyperbolic model param	0.3	0.4	0.5	0.6	-0.5	0.7	0.6	0.6	0.7
Intermittent access intake day 1-15 change	0.0	0.2	0.3	0.4	-0.4	0.2	0.5	0.5	0.6
Intermittent access intake escalation	0.1	0.4	0.7	0.6	-0.6	0.5	0.7	0.7	0.8
Intermittent access intake escalation 2	1.0	1.7	2.4	1.3	-1.2	1.0	1.3	1.3	1.5
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.2	0.4	-0.2	0.2	0.2	0.1	0.3
Intermitt. access day 15 inactive lever presses	0.0	0.1	0.5	0.7	-0.2	0.2	0.2	0.2	0.3
Intermitt. access escalation Index	0.1	0.4	1.5	1.2	-0.1	0.2	0.1	0.1	0.8
Intermittent access day 1 total infusions	0.9	2.7	4.2	-1.2	2.1	-1.7	-1.7	-1.7	-1.2
Intermittent access day 15 total infusions	0.4	1.1	1.8	-0.8	1.3	-1.2	-1.0	-1.1	-0.7
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.7	-0.4	0.9	-0.7	-0.6	-0.6	-0.3
Intermittent access total infusions	1.3	1.5	2.7	-0.5	1.6	-1.3	-1.3	-1.3	-0.8
Intermittent access day 1 locomotion	0.5	1.0	1.6	-0.6	1.3	-1.1	-1.1	-1.0	-0.6
Intermittent access day 15 total locomotion	0.9	3.4	4.6	-1.1	2.2	-2.0	-2.0	-2.0	-1.6
Intermittent access total locomotion	2.5	3.0	4.6	-0.7	2.1	-2.0	-1.9	-1.9	-1.3
Intermittent access standard deviation	0.1	0.3	0.5	0.4	-0.5	0.4	0.7	0.7	0.7
Left kidney weight	0.2	1.4	3.4	-1.8	1.0	-0.9	-1.0	-1.1	-0.8
Right kidney weight	0.1	0.9	3.1	-1.8	0.7	-0.3	-0.7	-0.7	-1.0
Cocaine induced anxiety	0.1	0.2	0.5	-0.1	0.3	-0.5	-0.4	-0.4	-0.7
Post-drug Anxiety	0.2	0.2	0.3	0.4	0.3	-0.5	-0.5	-0.5	-0.5
Baseline Anxiety	0.1	0.1	0.2	0.5	0.3	-0.3	-0.3	-0.3	-0.0
Tail length	4.0	21.6	34.1	-5.8	4.3	-4.0	-4.4	-4.5	-4.6
Length with tail	3.1	13.6	32.0	-5.7	3.0	-2.8	-3.2	-3.2	-3.5
Length without tail	0.1	0.4	1.0	-1.0	-0.8	0.8	0.3	0.5	0.1
Times rat made contact with spout	0.6	0.7	2.0	-1.4	0.6	-0.6	-0.5	-0.5	-1.1
Lifetime Intake	1.0	1.3	2.5	-0.5	1.6	-1.3	-1.2	-1.2	-0.5
Liver weight, left	0.3	0.6	2.6	-1.6	0.5	-0.2	-0.5	-0.4	-0.4
Liver weight, right	1.3	2.3	4.5	-2.1	1.0	-0.8	-1.5	-1.4	-1.9
Locomotor activity	0.2	0.2	0.8	-0.9	-0.5	0.4	-0.3	-0.2	-0.2
Locomotor testing distance	0.4	1.1	1.7	0.6	-1.3	1.2	0.8	0.9	1.3
Locomotor testing rearing	0.2	0.9	2.0	0.8	-1.0	0.7	0.7	0.7	1.4
Locomotion in novel chamber	6.0	8.0	10.6	-3.3	2.7	-2.7	-2.8	-2.8	-2.6
Locomotion in novel chamber post-restriction	1.6	4.7	5.8	-2.1	2.4	-2.2	-2.2	-2.3	-1.8
Fecal boli incidents, locomotor time 1	0.1	0.3	1.0	-1.0	-0.5	0.5	0.3	0.2	0.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.4	0.2	0.7	-0.6	-0.5	-0.5	-0.6
Time >=10cm from walls, locomotor time 1	0.7	0.9	1.6	0.3	1.2	-0.7	-1.2	-1.3	-0.6
Bouts of movement, locomotor time 1	0.2	0.2	0.5	-0.2	-0.5	0.2	0.7	0.7	0.5
Total resting periods, locomotor time 1	0.2	0.3	0.5	0.1	-0.5	0.3	0.7	0.7	0.5
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.3	0.5	-0.5	-0.2	-0.2	-0.3
Distance moved, locomotor task time 1	0.2	0.5	0.9	-0.2	-0.9	0.9	0.6	0.6	0.5
Vertical activity count, locomotor time 1	0.1	0.9	1.7	0.2	-1.3	1.0	1.0	0.9	1.0
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.6	-0.3	0.8	-0.5	-0.8	-0.8	-0.2
Bouts of movement, locomotor time 2	0.0	0.2	0.8	-0.9	0.2	-0.1	0.1	0.1	-0.4
Total resting periods, locomotor time 2	0.0	0.1	0.4	-0.6	0.1	-0.0	0.2	0.2	-0.4
Rest time, locomotor task time 2	0.6	1.1	2.3	-0.8	1.0	-1.2	-0.8	-0.7	-1.5
Distance moved, locomotor task time 2	1.1	1.5	2.6	0.4	-1.2	1.5	1.0	1.0	1.6
Vertical activity count, locomotor time 2	1.2	2.7	4.4	0.7	-1.8	1.9	1.5	1.5	2.1
Light reinforcement 1	0.1	0.3	0.5	0.7	-0.5	0.4	0.6	0.5	0.2
Light reinforcement 2	1.6	3.7	5.7	1.1	-2.2	2.4	2.2	2.0	1.3
Bone: marrow area	0.9	2.2	3.6	-1.9	0.8	-1.3	-1.7	-1.6	-1.2
Bone: maximum diameter	0.1	0.1	0.8	-0.9	-0.2	0.1	-0.1	-0.1	-0.3
Bone: maximum force	0.6	1.1	1.4	-1.2	1.0	-1.0	-1.0	-1.0	-1.1
Bone: maximum moment	0.4	0.7	0.9	-1.0	0.9	-0.8	-0.8	-0.8	-0.8
Mean time between licks in bursts	0.0	0.2	0.7	0.8	-0.1	0.1	0.2	0.2	0.4
Mean num. licks in bursts	0.1	0.1	0.3	0.4	-0.2	0.1	0.4	0.4	0.5
Cd content in liver	0.1	0.1	0.4	-0.5	0.6	-0.3	-0.3	-0.3	-0.0
Co content in liver	0.1	0.1	0.1	-0.2	-0.3	0.4	0.3	0.3	-0.4
Cu content in liver	2.8	3.3	3.8	1.2	-1.8	1.9	2.0	2.0	2.0
Fe content in liver	6.6	8.1	11.4	2.1	-2.9	3.2	2.6	2.6	3.4
K content in liver	0.4	0.4	1.0	-0.8	0.4	-0.4	-0.4	-0.4	-1.0
Mg content in liver	0.3	0.3	0.7	-0.7	0.5	-0.9	-0.1	-0.1	-0.7
Mn content in liver	0.3	0.3	1.0	-1.0	0.2	-0.8	0.0	0.0	-0.5
Na content in liver	1.6	1.8	2.9	-1.1	1.4	-0.9	-1.4	-1.4	-1.7
Rb content in liver	1.5	1.8	4.8	2.2	-0.8	0.4	1.2	1.2	1.6
Se content in liver	3.3	3.9	5.2	2.3	-2.2	2.1	1.7	1.7	1.8
Sr content in liver	0.4	0.3	1.1	-1.0	-0.2	0.2	-0.2	-0.2	-0.8
Zn content in liver	0.3	0.3	0.5	-0.5	-0.7	0.7	0.5	0.5	0.1
Bone: minimum diameter	0.0	0.1	0.2	-0.4	0.2	-0.2	-0.3	-0.3	0.0
Time in familiar zone, hab. session 1	0.5	0.5	0.9	0.7	-0.9	0.7	0.6	0.6	0.7
Time in novel zone, hab. session 1	0.0	0.0	0.1	-0.3	0.3	-0.2	-0.1	-0.2	0.1
Total zone transitions, hab. session 1	7.8	11.0	12.2	-2.9	3.3	-3.5	-3.5	-3.5	-3.3
Total locomotion distance, hab. session 1	1.9	2.7	3.4	-1.0	1.8	-1.8	-1.8	-1.7	-1.5
Locomotion velocity, hab. session 1	1.7	2.4	3.0	-1.0	1.7	-1.7	-1.6	-1.6	-1.5
Time in familiar zone, hab. session 2	1.9	2.2	2.6	1.5	-1.5	1.6	1.5	1.5	1.4
Time in novel zone, hab. session 2	0.5	0.5	0.7	-0.8	0.7	-0.8	-0.7	-0.7	-0.5
Total zone transitions, hab. session 2	2.0	2.5	2.9	-1.7	1.5	-1.7	-1.7	-1.6	-1.3
Total locomotion distance, hab. session 2	1.0	1.3	1.6	-1.0	1.1	-1.3	-1.2	-1.2	-1.0
Locomotion velocity, hab. session 2	1.2	1.6	1.9	-1.1	1.2	-1.4	-1.4	-1.3	-1.2
Novel to familiar place preference ratio	0.0	0.0	0.1	-0.1	0.2	-0.1	-0.1	-0.1	-0.3
Novelty place preference	0.0	0.0	0.0	-0.0	0.2	-0.0	-0.0	-0.0	-0.2
Time in novel zone, NPP test	0.0	0.0	0.0	-0.1	0.1	0.0	0.0	0.0	-0.2
Total zone transitions, NPP test	1.5	2.2	4.1	-2.0	1.5	-1.4	-1.3	-1.3	-1.2
Total locomotion distance, NPP test	1.6	2.2	2.4	-1.3	1.5	-1.5	-1.5	-1.5	-1.6
Locomotion velocity, NPP test	2.2	3.1	3.3	-1.6	1.8	-1.8	-1.8	-1.8	-1.8
Intraocular pressure	0.0	0.1	0.2	0.4	-0.0	0.3	0.1	0.1	0.1
Delta distance traveled before/after self-admin	1.1	1.3	2.7	-1.7	1.0	-1.2	-1.0	-1.0	-0.7
Delta ambulatory time before/after self-admin	0.1	0.2	1.2	-1.1	0.2	-0.4	-0.2	-0.2	-0.1
Parametrial fat weight	0.0	0.1	0.2	0.0	-0.0	0.1	-0.4	-0.3	-0.4
Pavlov. Cond. lever latency	0.7	0.8	1.6	0.7	-0.9	0.9	0.8	0.9	1.3
Pavlov. Cond. magazine entry latency	4.3	5.5	5.9	-2.4	2.2	-2.3	-2.4	-2.4	-2.3
Pavlov. Cond. change in total contacts	0.4	0.4	0.6	-0.8	0.4	-0.6	-0.6	-0.7	-0.7
Pavlov. Cond. index score	2.4	3.1	3.7	-1.7	1.6	-1.7	-1.8	-1.8	-1.9
Pavlov. Cond. latency score	2.5	3.1	3.9	-1.7	1.7	-1.8	-1.7	-1.8	-2.0
Pavlov. Cond. lever contacts	1.3	1.6	2.6	-0.9	1.2	-1.3	-1.2	-1.3	-1.6
Pavlov. Cond. magazine entry number	4.5	5.7	6.1	2.3	-2.2	2.4	2.4	2.5	2.5
Pavlov. Cond. intertrial magazine entries	0.6	0.7	0.8	0.9	-0.8	0.9	0.9	0.9	0.5
Pavlov. Cond. lever-magazine prob. diff.	1.8	2.2	3.0	-1.4	1.2	-1.4	-1.5	-1.6	-1.7
Pavlov. Cond. response bias	3.0	3.7	4.3	-1.9	1.8	-1.9	-1.9	-2.0	-2.1
Pavlov. Cond. lever latency	0.1	0.2	0.4	0.0	-0.4	0.4	0.6	0.6	0.4
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	0.3	-0.1	0.0	-0.2	-0.2	-0.3
Pavlov. Cond. change in total contacts	0.2	0.4	0.8	-0.5	0.9	-0.7	-0.5	-0.6	-0.3
Pavlov. Cond. index score	0.4	0.7	1.0	-0.4	0.9	-0.8	-0.9	-1.0	-0.9
Pavlov. Cond. latency score	0.3	0.5	0.7	-0.4	0.8	-0.7	-0.8	-0.9	-0.8
Pavlov. Cond. lever contacts	0.1	0.1	0.3	0.2	0.3	-0.3	-0.5	-0.5	-0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.2	-0.2	-0.0	0.2	0.4	0.5	0.4
Pavlov. Cond. intertrial magazine entries	0.7	1.5	1.8	-1.4	1.3	-1.3	-1.2	-1.2	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.8	-0.4	0.8	-0.7	-0.9	-0.9	-0.8
Pavlov. Cond. response bias	0.2	0.3	0.6	0.2	0.4	-0.5	-0.7	-0.8	-0.5
Time in closed arm before self-admin	0.2	0.3	0.5	-0.2	-0.5	0.6	0.5	0.5	0.7
Time in closed arm after self-admin	0.4	0.4	1.6	-1.3	0.4	-0.5	-0.3	-0.4	-0.4
Time in open arm before self-admin	0.2	0.3	0.5	-0.0	0.5	-0.7	-0.5	-0.4	-0.6
Time in open arm after self-admin	0.0	0.0	0.1	0.0	0.3	-0.1	-0.1	-0.1	-0.3
Bone: periosteal estimation	0.3	0.7	1.6	-1.3	0.6	-0.7	-0.9	-0.9	-0.5
Bone: periosteal perimeter	0.1	0.1	0.5	-0.7	0.0	-0.1	-0.2	-0.2	0.1
Bone: post-yield work	0.9	1.5	3.0	0.6	-1.7	1.5	1.0	1.1	1.1
Progressive ratio test 1 active lever presses	1.0	1.7	2.7	-1.0	1.7	-1.5	-1.3	-1.3	-0.7
Progressive ratio test 1 breakpoint	1.0	1.7	2.8	-1.0	1.7	-1.6	-1.4	-1.4	-0.7
Progressive ratio test 1 inactive lever presses	0.2	0.5	1.0	-0.3	1.0	-0.9	-0.8	-0.8	-0.1
Progressive ratio test 2 active lever presses	3.1	4.4	6.5	-1.1	2.5	-2.4	-2.3	-2.3	-1.6
Progressive ratio test 2 breakpoint	3.3	4.2	6.2	-1.0	2.5	-2.3	-2.2	-2.2	-1.6
Progressive ratio test 2 inactive lever presses	1.2	3.9	6.0	-0.7	2.5	-2.4	-2.2	-2.3	-1.1
Incentive Sensitization - Responses	1.2	3.4	4.7	-0.6	2.2	-1.9	-2.1	-2.1	-1.7
Incentive Sensitization - Breakpoint	1.5	3.4	4.7	-0.6	2.2	-1.9	-2.1	-2.1	-1.8
Sum of active levers in priming session hrs 5-6	0.5	0.4	0.9	-0.3	0.9	-0.7	-0.5	-0.6	-0.8
Progressive ratio	0.8	2.4	3.4	-1.2	1.6	-1.5	-1.5	-1.5	-1.8
Food seeking constrained by brief footshock	2.2	2.8	3.7	1.1	-1.9	1.8	1.9	1.9	1.2
Seeking ratio, punishment vs. effort	1.2	2.6	3.1	1.1	-1.8	1.7	1.7	1.7	1.6
Retroperitoneal fat weight	0.3	1.4	2.6	0.9	-1.4	1.6	1.1	1.2	0.5
Reaction time number correct	0.3	1.1	2.0	-1.1	0.9	-0.5	-1.0	-1.0	-1.4
Reaction time mean minus median	0.7	4.7	6.8	-1.4	2.5	-2.6	-2.3	-2.2	-1.7
Reaction time mean minus median AUC	0.9	5.9	8.0	-1.7	2.8	-2.7	-2.5	-2.4	-2.1
Reaction time num false alarms	0.2	0.4	1.2	-0.9	0.3	-0.2	-0.4	-0.4	-1.1
Reaction time num false alarms AUC	0.1	0.2	0.6	-0.5	0.1	0.2	-0.0	-0.0	-0.8
Reaction time trials correct on left	0.3	1.1	2.0	-1.1	0.9	-0.5	-1.0	-1.0	-1.4
Reaction time trials on left	0.3	1.1	2.0	-1.1	1.0	-0.5	-1.0	-1.0	-1.4
Reaction time mean	0.2	0.4	1.8	1.4	-0.0	-0.2	0.0	0.2	0.7
Reaction time mean AUC	0.2	0.5	2.1	1.5	-0.1	-0.1	0.2	0.4	0.8
Median of all reaction times	1.4	2.2	5.2	2.3	-1.2	1.0	1.1	1.3	1.6
Reaction time omissions	0.1	0.1	0.5	0.1	0.4	-0.7	-0.3	-0.3	-0.2
Reaction time false alarm rate	0.1	0.2	0.3	0.0	-0.5	0.5	0.5	0.5	0.0
Reaction time premature initiation rate	4.3	6.7	9.9	-2.1	3.0	-3.2	-2.5	-2.6	-2.1
Reaction time premature initiations	2.7	8.2	10.6	-2.5	3.3	-3.2	-2.8	-2.8	-2.5
Std. dev. reaction times	0.9	2.9	5.1	-0.6	2.0	-2.2	-1.9	-1.8	-1.1
Reaction time trials completed	0.3	1.1	2.0	-1.1	1.0	-0.5	-1.0	-1.0	-1.4
Reaction time trials AUC	0.2	0.8	1.5	-1.0	0.8	-0.4	-0.9	-0.9	-1.2
Run reversals in cocaine runway, females	0.4	0.4	0.6	0.7	-0.7	0.4	0.7	0.8	0.6
Run reversals in cocaine runway, males	1.4	1.6	3.2	0.5	-1.7	1.8	1.3	1.0	0.6
Latency to leave start box in cocaine runway	0.5	0.7	0.9	0.9	-0.7	0.9	1.0	0.8	0.6
Latency to leave start box in cocaine runway, F	0.8	1.0	1.4	1.2	-0.8	1.0	1.2	1.1	0.6
Latency to leave start box in cocaine runway, M	0.1	0.1	0.3	-0.5	-0.1	0.0	-0.1	-0.2	-0.1
Std. dev. time between licks in bursts	0.3	0.6	0.8	-0.3	0.9	-0.9	-0.9	-0.9	-0.6
Total sessions with >9 infusions	0.2	0.3	1.2	0.1	-0.1	0.4	0.4	0.4	1.1
Short access day 1 total inactive lever presses	0.7	1.4	1.9	-1.1	1.2	-1.0	-1.2	-1.2	-1.4
Short access day 10 total inactive lever presses	0.0	0.0	0.1	0.4	-0.0	-0.2	-0.1	-0.1	-0.3
Short access day 1 total infusions	0.1	0.2	0.7	0.3	0.0	0.2	0.2	0.3	0.8
Short access day 10 total infusions	0.3	0.4	0.9	-0.7	1.0	-0.6	-0.7	-0.6	-0.2
Short access total infusions	0.2	0.3	0.7	-0.1	0.9	-0.6	-0.6	-0.6	0.2
Short access day 1 locomotion	0.1	0.2	0.8	0.3	-0.1	0.3	0.4	0.4	0.9
Short access day 10 total locomotion	0.0	0.0	0.0	-0.1	-0.0	-0.1	0.1	0.1	-0.0
Short access total locomotion	0.1	0.2	0.3	0.1	0.5	-0.4	-0.3	-0.3	0.6
One hour access (0.3 mA shock)	2.0	2.3	3.0	-1.3	1.7	-1.7	-1.6	-1.6	-1.1
Compulsive drug intake	0.2	0.3	0.6	0.5	-0.5	0.2	0.5	0.5	0.8
One hour access (shock baseline)	0.9	2.2	2.9	-1.1	1.7	-1.4	-1.6	-1.7	-1.3
Social response proportion	1.1	1.4	2.6	-0.9	1.4	-1.6	-1.2	-1.2	0.0
Social responses	3.9	5.1	5.9	-2.4	2.3	-2.4	-2.3	-2.3	-1.7
Social time	0.1	0.2	0.6	0.7	-0.1	0.2	0.3	0.2	0.8
Soleus weight	0.1	0.2	0.3	-0.1	-0.5	0.2	0.4	0.4	0.6
Bone: stiffness	1.4	2.6	3.0	-1.7	1.3	-1.5	-1.7	-1.7	-1.7
Tibialis anterior weight	0.1	0.3	1.3	-1.2	-0.0	0.1	-0.5	-0.4	0.1
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.8	0.9	-0.5	0.4	0.6	0.6	0.5
Time to tail flick, vehicle, after self-admin	0.2	0.4	1.0	-1.0	0.6	-0.5	-0.4	-0.5	-0.5
Time to tail flick, test, before self-admin	0.8	0.9	1.3	-1.2	0.8	-0.9	-1.0	-0.9	-0.9
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.4	-0.2	0.4	0.6	0.5	0.2
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.1	-0.2	0.3	0.2	0.2	0.1
Delta time to tail flick, test, before/after SA	0.3	0.4	0.7	0.9	-0.5	0.7	0.8	0.7	0.3
Tibia length	0.7	1.9	2.7	-1.6	1.1	-0.9	-1.6	-1.6	-1.2
Ambulatory time before self-admin	0.8	2.3	3.0	1.5	-1.6	1.7	1.6	1.6	1.1
Ambulatory time after self-admin	0.8	1.2	1.8	0.3	-1.2	1.3	1.3	1.2	0.8
Bone: tissue strength	0.6	0.6	0.9	0.6	-0.8	0.8	0.7	0.8	1.0
Total heroin consumption	0.3	0.4	1.4	-0.8	0.3	-0.1	-0.0	-0.1	-1.2
Bone: trabecular number	0.3	0.6	0.9	0.7	-1.0	0.8	0.6	0.6	0.9
Bone: trabecular spacing	0.0	0.0	0.2	0.4	0.2	-0.1	-0.2	-0.2	0.0
Bone: trabecular thickness	0.7	1.0	1.5	0.9	-1.0	0.9	1.0	1.0	1.2
Bone: trabecular tissue density	0.5	0.9	1.2	-0.5	0.9	-1.0	-1.1	-1.1	-0.9
Water consumed over 24 hours	1.2	2.3	2.6	-1.6	1.5	-1.5	-1.4	-1.4	-1.6
Number of responses in last shaping day	0.9	1.2	1.4	0.7	-1.1	1.1	1.1	1.2	1.2