LOC108352141

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	intron excision ratio	chr10_90344450_90356529	0.08	0.04	9.1e-09	0.06	0.06	0.06	0.06	3.8e-09	3.5e-10	6.7e-10	4.5e-10
2	NAcc	intron excision ratio	chr10_90403321_90403679	0.05	0.03	7.5e-06	0.04	0.04	0.04	0.03	3.5e-06	2.8e-06	1.9e-06	5.5e-06
3	PL	intron excision ratio	chr10_90356641_90410849	0.04	0.03	5.2e-03	0	0.01	0	0	2.6e-01	9.0e-03	7.5e-02	2.4e-01
4	NAcc	intron excision ratio	chr10_90356641_90410849	0.03	0.02	4.1e-03	0	0.01	0.01	0.01	5.7e-02	1.8e-03	3.2e-02	1.2e-02
5	NAcc	gene expression	LOC108352141	0.02	0.01	6.8e-03	0.01	0.01	0.01	0.01	2.4e-02	5.6e-03	2.4e-02	1.2e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	2.7	4.7	7.4	1.0	-2.4	2.7	2.7	1.4
Area under the delay curve	0.1	0.2	0.6	0.8	-0.1	0.3	0.3	-0.3
BMI with tail	3.9	13.5	19.2	1.9	4.4	-3.7	-3.8	-4.0
BMI without tail	2.6	7.8	10.5	2.7	3.2	-2.7	-2.7	-2.5
Body weight	3.1	13.4	21.4	4.6	4.0	-3.0	-3.0	-3.3
Weight adjusted by age	0.7	1.0	1.5	0.9	1.2	-0.9	-0.9	-1.1
Bone surface	1.8	3.2	10.5	3.2	-0.8	1.6	1.6	0.1
Bone volume	1.9	3.4	8.1	2.8	-1.3	1.9	1.9	0.5
Breakpoint value in progressive ratio session	0.0	0.1	0.2	0.2	-0.1	-0.2	-0.1	0.4
Number of licking bursts	0.2	0.4	0.6	0.7	0.8	-0.4	-0.5	-0.7
Context. condit. distance diff. score	1.4	1.7	2.4	-0.8	1.4	-1.5	-1.5	-1.1
Locomotion velocity, session 1	1.9	2.1	2.6	1.1	-1.6	1.4	1.6	1.4
Locomotion distance, session 1	1.1	1.4	1.9	0.5	-1.3	1.3	1.4	1.3
Locomotion velocity, session 2	1.5	1.7	3.2	0.2	-1.7	1.0	1.2	1.8
Locomotion distance, session 2	0.5	0.6	1.7	-0.3	-0.9	0.5	0.6	1.3
Locomotion velocity, session 3	0.9	1.0	1.7	-0.0	-1.3	1.2	1.2	0.7
Locomotion distance, session 3	0.3	0.4	0.6	0.3	-0.7	0.8	0.8	-0.0
Stereotopy head waving bouts, day 3	2.1	2.5	3.6	-0.6	-1.9	1.8	1.9	1.2
Stereotopy head waving duration, day 3	0.7	0.8	1.2	-0.6	-1.0	0.9	0.9	1.1
Locomotion velocity, session 7	0.5	0.5	0.9	-0.4	-0.8	0.9	0.9	0.5
Locomotion distance, session 7	0.0	0.0	0.1	-0.4	0.1	0.0	-0.0	-0.1
Stereotopy head waving bouts, day 7	1.5	1.7	2.3	-0.8	-1.5	1.5	1.4	1.1
Stereotopy head waving duration, day 7	2.5	3.0	3.9	-1.6	-2.0	1.6	1.6	1.8
Locomotion velocity, session 8	1.1	1.3	2.2	1.0	1.1	-1.5	-1.4	-0.3
Locomotion distance, session 8	0.3	0.4	0.6	-0.8	0.2	-0.8	-0.7	0.6
Degree of sensitization distance	0.8	0.9	1.6	0.0	1.3	-1.1	-1.2	-0.3
Degree of sensitization stereotypy	0.7	0.8	1.3	-1.2	-1.0	0.9	0.8	0.6
Conditioned locomotion	0.1	0.1	0.2	-0.5	0.0	-0.2	-0.2	0.4
Cocaine response after cond. corrected	0.7	0.8	3.0	0.7	0.6	0.0	-0.1	-1.7
Cocaine response after cond. not corrected	0.6	0.8	1.7	0.8	-0.2	0.9	0.8	-1.3
Cocaine response before conditioning	1.7	2.0	2.7	0.1	-1.6	1.6	1.7	1.3
Saline control response	1.6	2.1	4.4	0.2	1.4	-2.1	-2.0	-0.3
Bone: connectivity density	2.4	3.8	5.8	1.1	-2.1	2.4	2.4	1.4
Bone: cortical apparent density	4.3	5.9	7.5	-2.5	-2.7	2.4	2.4	2.0
Bone: cortical area	1.0	1.6	4.2	2.0	-0.3	1.2	1.1	-1.1
Bone: cortical porosity	4.1	4.4	18.3	4.3	0.9	0.0	-0.0	-1.8
Bone: cortical porosity	4.1	4.5	16.0	4.0	1.3	-0.3	-0.4	-2.1
Bone: cortical thickness	2.7	4.4	8.6	-1.1	-2.1	2.9	2.7	-0.4
Bone: cortical thickness	2.9	3.4	5.6	-1.3	-2.1	2.4	2.3	0.4
Bone: cortical tissue density	4.3	5.8	7.5	-2.5	-2.7	2.4	2.4	2.1
Condit. Reinf. active minus inactive responses	0.3	0.4	1.6	1.3	-0.1	-0.2	-0.0	0.4
Condit. Reinf. active-inactive response ratio	0.0	0.0	0.1	0.3	0.0	-0.2	-0.2	-0.2
Condit. Reinf. active responses	0.5	0.6	1.8	1.4	-0.4	0.0	0.2	1.0
Condit. Reinf. inactive responses	0.7	0.9	2.0	0.9	-0.8	0.6	0.7	1.4
Incentive salience index mean	0.6	0.7	1.7	1.3	-0.7	0.6	0.7	0.8
Condit. Reinf. lever presses	1.0	1.4	1.8	0.5	-1.3	1.3	1.3	1.3
Condit. Reinf. active minus inactive responses	1.2	1.6	4.8	2.2	-0.8	0.9	1.0	0.7
Condit. Reinf. active-inactive response ratio	0.9	1.0	3.5	1.9	-0.5	0.8	0.8	0.3
Condit. Reinf. active responses	1.2	1.7	5.4	2.3	-0.7	0.6	0.8	1.2
Condit. Reinf. inactive responses	0.8	1.0	3.5	0.8	-0.8	0.3	0.5	1.9
Condit. Reinf. lever presses	0.4	0.5	1.1	1.1	-0.6	0.4	0.5	0.8
Condit. Reinf. lever reinforcers received	1.1	1.6	4.7	2.2	-0.8	0.7	0.9	1.1
Conditioned reinforcement - actives	0.5	0.8	1.3	0.7	1.0	-1.1	-1.0	-0.4
Conditioned reinforcement - inactives	0.6	0.9	1.5	1.2	1.1	-0.6	-0.7	-1.1
Conditioned locomotion	0.9	1.2	2.8	1.7	1.1	-0.9	-0.9	-0.7
Patch foraging indifference point 0 sec	0.4	0.7	1.7	1.3	-0.4	0.3	0.4	1.3
Patch foraging indifference point AUC	0.4	0.5	0.9	0.5	0.9	-0.9	-0.9	-0.2
Delay disc. indifference point, 0s delay	0.4	0.4	0.7	-0.3	-0.8	0.5	0.7	0.8
Delay disc. indifference point, 16s delay	1.1	1.2	2.0	1.4	1.1	-0.6	-0.6	-1.4
Delay disc. indifference point, 2s delay	2.0	2.2	2.9	1.0	-1.6	1.5	1.7	1.5
Delay disc. indifference point, 24s delay	0.5	0.5	1.6	1.3	0.6	-0.4	-0.3	-0.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.6	0.8	-0.0	0.4	0.4	-0.6
Delay disc. indifference point, 8s delay	0.9	1.1	1.8	-0.3	-1.3	1.3	1.3	0.5
Indifference point function ln k	0.8	1.4	2.7	0.5	-1.2	1.6	1.5	0.7
Indifference point function log k	0.8	1.4	2.7	0.5	-1.2	1.6	1.5	0.7
Patch foraging total patch changes 0 sec	0.4	0.8	2.6	1.6	-0.2	0.2	0.3	1.0
Patch foraging total patch changes 12 sec	0.5	0.6	2.6	0.3	-0.2	-0.6	-0.3	1.6
Patch foraging total patch changes 18 sec	0.7	1.1	1.4	1.1	1.2	-1.2	-1.1	-0.6
Patch foraging total patch changes 24 sec	0.4	0.7	2.0	1.4	-0.4	0.4	0.5	1.0
Patch foraging total patch changes 6 sec	0.2	0.3	1.4	1.2	0.1	-0.1	-0.0	0.4
Patch foraging time to switch 0 sec	0.0	0.0	0.1	-0.2	0.0	0.0	-0.0	-0.3
Patch foraging water rate 0 sec	0.2	0.4	2.1	1.4	0.2	-0.0	-0.0	0.1
Patch foraging water rate 12 sec	0.2	0.5	1.1	0.4	-0.2	0.9	0.7	-1.0
Patch foraging water rate 18 sec	1.5	2.3	3.6	-0.0	-1.8	1.9	1.9	1.0
Patch foraging water rate 24 sec	0.1	0.2	0.3	-0.6	-0.4	0.4	0.5	-0.2
Patch foraging water rate 6 sec	0.6	0.8	1.5	0.9	-0.8	1.2	1.1	0.2
Seeking ratio, delayed vs. immediate footshock	2.0	2.4	3.5	0.3	1.8	-1.8	-1.9	-1.4
Distance traveled before self-admin	0.2	0.3	0.7	0.9	0.1	0.3	0.3	-0.7
Distance traveled after self-admin	0.3	0.4	0.6	-0.7	0.5	-0.7	-0.6	-0.8
Extensor digitorum longus weight	2.3	8.9	12.5	-2.0	3.2	-3.5	-3.5	-2.4
Bone: elastic displacement	1.2	1.3	2.4	-0.7	-1.3	1.5	1.5	-0.2
Bone: elastic work	0.9	1.2	2.2	0.6	-1.0	1.5	1.4	-0.3
Bone: endosteal estimation	3.3	7.1	24.8	5.0	2.1	-1.7	-1.6	-1.1
Bone: endosteal perimeter	5.9	12.6	33.5	5.8	3.3	-2.6	-2.5	-2.4
Epididymis fat weight	0.4	1.3	2.0	1.4	1.3	-1.1	-1.1	-0.7
Delta time in closed arm before/after self-admin	0.6	0.6	0.8	-0.8	-0.6	0.9	0.8	-0.5
Delta time in open arm before/after self-admin	0.6	0.5	2.1	-0.4	-0.1	-0.5	-0.4	1.4
Diff in mean of infusions in LGA sessions	0.1	0.1	0.3	-0.5	0.1	-0.1	-0.2	0.3
Delay discount exponential model param	0.2	0.2	0.8	-0.9	-0.0	-0.2	-0.2	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.4	-0.4	0.1	-0.6	-0.5	0.3
Active lever presses in extinction session 6	0.6	0.6	1.8	1.4	0.7	-0.5	-0.5	-0.4
Bone: final force	0.8	1.3	2.3	1.0	-0.9	1.5	1.5	-0.7
Bone: final moment	1.2	1.9	3.3	1.1	-1.2	1.8	1.8	-0.6
Food consumed during 24 hour testing period	2.2	3.0	3.9	1.8	2.0	-1.9	-1.9	-0.9
Glucose	0.4	0.6	1.5	-0.6	0.6	-0.7	-0.7	-1.2
Heart weight	1.1	1.7	5.1	0.4	1.4	-0.8	-0.9	-2.3
Delay discount hyperbolic model param	0.2	0.2	0.9	-1.0	0.1	-0.3	-0.3	0.1
Intermittent access intake day 1-15 change	0.7	1.4	2.0	-0.0	1.1	-1.4	-1.3	-1.4
Intermittent access intake escalation	1.0	2.0	3.0	0.2	1.3	-1.7	-1.5	-1.7
Intermittent access intake escalation 2	1.5	1.8	2.5	0.4	1.3	-1.6	-1.4	-1.6
Intermitt. access day 1 inactive lever presses	0.2	0.7	2.8	1.7	-0.2	0.4	0.4	0.4
Intermitt. access day 15 inactive lever presses	0.5	1.0	3.1	1.8	-0.2	0.9	0.8	0.6
Intermitt. access escalation Index	0.6	0.8	1.5	-1.2	0.7	-0.5	-0.6	-1.2
Intermittent access day 1 total infusions	0.1	0.1	0.3	0.5	-0.2	0.2	0.2	0.4
Intermittent access day 15 total infusions	1.7	2.5	4.0	0.8	1.6	-2.0	-1.8	-1.5
Intermittent access terminal intake (last 3 days)	1.7	2.2	3.2	1.3	1.6	-1.8	-1.6	-1.0
Intermittent access total infusions	0.8	0.9	1.6	0.9	0.9	-1.3	-1.1	-0.3
Intermittent access day 1 locomotion	0.7	0.9	3.2	1.8	0.9	-0.5	-0.5	-0.5
Intermittent access day 15 total locomotion	1.2	2.1	3.1	1.3	1.5	-1.8	-1.6	-0.9
Intermittent access total locomotion	1.2	1.4	3.9	2.0	1.0	-1.0	-0.9	-0.3
Intermittent access standard deviation	0.0	0.0	0.1	0.0	-0.2	-0.1	0.0	0.4
Left kidney weight	0.1	0.4	0.7	0.5	-0.1	0.8	0.6	-0.8
Right kidney weight	0.1	0.6	1.5	0.8	0.3	0.6	0.4	-1.2
Cocaine induced anxiety	0.5	0.8	1.2	-1.0	-0.8	1.1	0.9	-0.2
Post-drug Anxiety	0.2	0.2	0.7	-0.2	0.0	0.6	0.4	-0.8
Baseline Anxiety	0.8	1.0	1.5	1.2	1.2	-0.8	-0.8	-0.8
Tail length	0.8	2.9	10.6	3.3	-0.6	1.0	1.1	1.2
Length with tail	0.5	2.2	10.7	3.3	0.7	-0.2	-0.1	-0.0
Length without tail	0.4	1.4	1.8	1.2	1.3	-1.0	-1.0	-1.3
Times rat made contact with spout	0.4	0.4	0.5	0.7	0.7	-0.5	-0.6	-0.6
Lifetime Intake	0.5	0.7	1.1	1.1	0.7	-0.9	-0.8	-0.2
Liver weight, left	0.6	1.0	5.0	2.2	0.1	-0.0	-0.0	-0.2
Liver weight, right	1.4	2.4	5.1	-0.1	-1.6	2.3	2.1	0.0
Locomotor activity	0.1	0.1	0.4	-0.1	-0.2	-0.2	-0.2	0.6
Locomotor testing distance	0.1	0.1	0.3	0.2	0.2	-0.6	-0.5	0.3
Locomotor testing rearing	0.6	1.3	2.9	-0.5	0.9	-1.7	-1.5	-0.3
Locomotion in novel chamber	0.7	1.0	1.9	1.4	1.0	-0.1	-0.3	-1.4
Locomotion in novel chamber post-restriction	0.2	0.3	1.3	1.1	0.2	0.0	0.0	0.2
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.5	0.1	-0.1	-0.1	-0.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.2	0.4	-0.2	-0.2	-0.5
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.1	-1.5	0.7	-0.4	-0.6	-0.9
Bouts of movement, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	0.5	0.4	0.2
Total resting periods, locomotor time 1	0.1	0.1	0.4	-0.1	-0.2	0.6	0.5	0.0
Rest time, locomotor task time 1	1.1	1.4	2.1	-0.5	-1.3	1.4	1.4	1.0
Distance moved, locomotor task time 1	1.0	1.5	2.1	1.0	1.4	-1.2	-1.2	-1.2
Vertical activity count, locomotor time 1	0.3	0.7	1.2	1.1	0.8	-0.5	-0.5	-1.0
Time >=10cm from walls, locomotor time 2	0.4	0.6	1.7	0.6	0.9	-0.3	-0.5	-1.3
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.3	0.2	-0.0	-0.1	-0.2
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.1	0.1	0.1	0.1	-0.3
Rest time, locomotor task time 2	0.2	0.3	1.4	-1.2	0.0	0.1	0.1	-0.2
Distance moved, locomotor task time 2	0.1	0.1	0.4	0.6	0.1	-0.1	-0.1	-0.4
Vertical activity count, locomotor time 2	0.3	0.5	0.5	0.7	-0.7	0.6	0.7	0.7
Light reinforcement 1	0.8	2.0	5.3	0.3	-1.4	1.1	1.3	2.3
Light reinforcement 2	2.2	3.4	5.2	0.4	-2.0	1.9	2.0	2.3
Bone: marrow area	3.2	6.9	24.1	4.9	2.1	-1.6	-1.5	-1.2
Bone: maximum diameter	1.5	2.8	11.8	3.4	0.7	0.1	0.1	-1.2
Bone: maximum force	0.8	1.3	3.7	1.9	0.1	0.8	0.7	-1.4
Bone: maximum moment	0.9	1.5	4.0	2.0	-0.3	1.1	1.1	-1.1
Mean time between licks in bursts	1.2	3.0	4.6	0.9	2.0	-1.6	-1.7	-2.1
Mean num. licks in bursts	0.0	0.0	0.1	-0.1	-0.2	-0.0	0.0	0.2
Cd content in liver	1.3	1.4	6.6	-2.6	-0.2	-0.4	-0.4	0.4
Co content in liver	0.4	0.5	1.8	-1.4	-0.2	-0.2	-0.2	0.7
Cu content in liver	0.3	0.4	0.6	0.7	-0.4	0.6	0.6	0.8
Fe content in liver	0.9	1.1	1.6	-0.6	-1.3	1.0	1.0	1.2
K content in liver	1.5	1.4	2.5	-0.0	-1.3	1.2	1.2	1.6
Mg content in liver	4.2	4.3	6.4	-1.9	-2.2	1.8	1.8	2.5
Mn content in liver	7.2	8.0	10.7	-1.0	-3.3	3.0	3.1	3.1
Na content in liver	0.4	0.5	1.8	0.1	-0.6	0.2	0.3	1.3
Rb content in liver	2.2	2.5	4.5	-2.1	-1.6	1.2	1.2	1.7
Se content in liver	0.5	0.5	2.6	-1.6	-0.3	0.1	0.0	0.2
Sr content in liver	0.7	0.6	1.3	1.2	0.6	-0.2	-0.2	-1.0
Zn content in liver	0.2	0.2	0.6	-0.8	-0.3	0.5	0.4	-0.4
Bone: minimum diameter	4.4	8.0	28.8	5.4	2.3	-1.2	-1.2	-1.8
Time in familiar zone, hab. session 1	1.4	1.3	2.3	0.3	1.3	-1.5	-1.5	-0.5
Time in novel zone, hab. session 1	0.8	0.8	1.5	-0.4	-0.9	1.2	1.2	-0.1
Total zone transitions, hab. session 1	0.1	0.2	0.3	0.1	0.5	-0.5	-0.5	-0.4
Total locomotion distance, hab. session 1	0.7	1.0	1.5	1.1	-0.9	1.2	1.2	0.5
Locomotion velocity, hab. session 1	0.7	1.0	1.6	1.3	-0.8	1.0	1.1	0.7
Time in familiar zone, hab. session 2	1.9	2.0	3.7	-0.1	1.5	-1.9	-1.8	-0.7
Time in novel zone, hab. session 2	3.1	3.1	5.8	0.1	-1.9	2.4	2.3	0.7
Total zone transitions, hab. session 2	0.2	0.3	0.5	-0.4	0.5	-0.7	-0.7	0.2
Total locomotion distance, hab. session 2	0.3	0.4	1.3	-0.1	-0.6	0.4	0.5	1.1
Locomotion velocity, hab. session 2	0.3	0.4	1.1	-0.1	-0.5	0.5	0.5	1.1
Novel to familiar place preference ratio	0.5	0.6	1.1	1.1	0.9	-0.3	-0.4	-0.9
Novelty place preference	0.3	0.4	0.8	0.9	0.7	-0.1	-0.2	-0.7
Time in novel zone, NPP test	0.3	0.3	0.6	0.8	0.6	-0.0	-0.1	-0.7
Total zone transitions, NPP test	0.4	0.6	1.3	-0.2	-0.9	0.6	0.7	1.1
Total locomotion distance, NPP test	1.2	1.6	2.0	0.5	-1.3	1.4	1.4	1.4
Locomotion velocity, NPP test	0.6	0.8	1.3	0.5	-0.9	0.9	0.9	1.2
Intraocular pressure	2.1	3.0	4.0	1.7	2.0	-1.7	-1.7	-1.6
Delta distance traveled before/after self-admin	0.5	0.5	1.8	-1.3	0.1	-0.6	-0.5	0.0
Delta ambulatory time before/after self-admin	0.3	0.4	1.1	-1.1	0.1	-0.6	-0.5	0.1
Parametrial fat weight	0.9	2.0	3.0	1.5	-1.3	1.7	1.7	0.6
Pavlov. Cond. lever latency	0.7	0.8	3.3	-1.8	0.2	-0.7	-0.7	-0.0
Pavlov. Cond. magazine entry latency	1.6	2.1	3.3	1.8	-1.3	1.3	1.4	1.3
Pavlov. Cond. change in total contacts	1.5	1.6	3.3	1.8	-1.0	1.0	1.1	1.3
Pavlov. Cond. index score	1.0	1.3	3.2	1.8	-0.8	1.0	1.1	0.7
Pavlov. Cond. latency score	0.7	0.9	2.8	1.7	-0.5	0.7	0.7	0.5
Pavlov. Cond. lever contacts	0.7	0.8	3.2	1.8	-0.3	0.6	0.6	0.2
Pavlov. Cond. magazine entry number	2.0	2.5	3.2	-1.3	1.7	-1.5	-1.7	-1.8
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.8	0.5	0.8	-1.3	-1.2	0.3
Pavlov. Cond. lever-magazine prob. diff.	1.3	1.7	4.2	2.1	-0.9	1.1	1.2	0.7
Pavlov. Cond. response bias	3.5	4.3	5.2	2.2	-2.0	2.2	2.3	1.7
Pavlov. Cond. lever latency	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.2	-0.5
Pavlov. Cond. magazine entry latency	0.2	0.3	1.0	-1.0	0.2	-0.4	-0.5	-0.1
Pavlov. Cond. change in total contacts	0.2	0.4	1.1	-0.1	0.0	-0.7	-0.6	1.0
Pavlov. Cond. index score	0.0	0.0	0.1	0.1	0.1	-0.3	-0.2	0.2
Pavlov. Cond. latency score	0.0	0.0	0.0	0.2	0.0	-0.2	-0.1	0.1
Pavlov. Cond. lever contacts	0.1	0.1	0.4	0.3	-0.4	0.2	0.3	0.6
Pavlov. Cond. magazine entry number	0.4	0.5	2.6	1.6	0.3	-0.1	-0.0	0.0
Pavlov. Cond. intertrial magazine entries	2.2	3.3	16.0	4.0	0.8	-0.2	-0.1	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.1	0.0	0.0	-0.2	-0.2	0.2
Pavlov. Cond. response bias	0.1	0.1	0.3	-0.2	-0.4	0.1	0.1	0.5
Time in closed arm before self-admin	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2	0.3
Time in closed arm after self-admin	0.2	0.2	0.7	-0.8	0.2	-0.1	-0.2	-0.6
Time in open arm before self-admin	1.2	1.4	5.6	-0.2	0.9	-0.3	-0.4	-2.4
Time in open arm after self-admin	1.1	1.2	1.8	0.7	1.3	-1.2	-1.2	-0.8
Bone: periosteal estimation	2.2	4.6	20.8	4.6	0.9	-0.1	-0.1	-1.2
Bone: periosteal perimeter	2.4	4.1	13.8	3.7	1.4	-0.4	-0.4	-2.1
Bone: post-yield work	2.5	3.7	5.5	2.1	2.2	-1.4	-1.5	-2.3
Progressive ratio test 1 active lever presses	0.5	0.6	2.7	1.7	0.5	-0.3	-0.2	-0.2
Progressive ratio test 1 breakpoint	0.5	0.7	3.0	1.7	0.5	-0.3	-0.2	-0.0
Progressive ratio test 1 inactive lever presses	0.4	0.6	2.9	1.7	0.5	-0.1	-0.1	0.1
Progressive ratio test 2 active lever presses	1.3	1.6	5.6	2.4	1.0	-0.6	-0.6	-0.6
Progressive ratio test 2 breakpoint	1.6	1.8	5.8	2.4	1.1	-0.8	-0.8	-0.8
Progressive ratio test 2 inactive lever presses	0.3	0.4	1.8	1.3	0.6	-0.1	-0.1	0.1
Incentive Sensitization - Responses	1.1	1.5	3.5	1.9	1.2	-0.9	-0.9	-1.1
Incentive Sensitization - Breakpoint	1.2	1.6	3.2	1.8	1.2	-1.0	-1.0	-1.1
Sum of active levers in priming session hrs 5-6	0.9	0.8	3.1	-1.8	-0.2	-0.6	-0.5	0.4
Progressive ratio	0.1	0.2	0.5	0.2	0.4	-0.7	-0.5	0.0
Food seeking constrained by brief footshock	1.8	2.3	4.8	0.4	1.5	-2.2	-2.0	-0.4
Seeking ratio, punishment vs. effort	0.2	0.3	0.5	0.5	0.5	-0.7	-0.7	-0.2
Retroperitoneal fat weight	0.1	0.5	1.6	1.3	-0.3	0.4	0.5	0.7
Reaction time number correct	0.0	0.1	0.3	0.2	-0.1	0.3	0.2	-0.5
Reaction time mean minus median	0.1	0.2	0.4	-0.2	-0.3	0.7	0.6	0.2
Reaction time mean minus median AUC	0.6	1.5	2.2	-1.2	-1.2	1.5	1.4	0.9
Reaction time num false alarms	1.5	2.1	5.5	2.4	1.4	-0.9	-1.0	-1.0
Reaction time num false alarms AUC	0.9	1.4	5.3	2.3	0.9	-0.5	-0.6	-0.5
Reaction time trials correct on left	0.0	0.1	0.3	0.2	-0.1	0.3	0.2	-0.5
Reaction time trials on left	0.1	0.1	0.3	0.3	-0.1	0.4	0.3	-0.5
Reaction time mean	1.5	2.4	3.0	-1.1	-1.7	1.7	1.7	1.4
Reaction time mean AUC	1.7	2.8	3.5	-1.4	-1.9	1.7	1.7	1.5
Median of all reaction times	1.9	2.7	3.5	-1.2	-1.9	1.8	1.8	1.6
Reaction time omissions	1.8	2.6	4.2	0.9	-1.6	2.0	2.0	1.2
Reaction time false alarm rate	0.7	1.0	3.6	1.9	0.9	-0.6	-0.6	-0.3
Reaction time premature initiation rate	0.2	0.3	0.9	1.0	0.4	-0.3	-0.3	0.2
Reaction time premature initiations	0.1	0.3	1.0	1.0	0.4	-0.3	-0.3	-0.0
Std. dev. reaction times	1.0	1.9	2.7	-0.7	-1.5	1.6	1.6	1.2
Reaction time trials completed	0.1	0.1	0.3	0.3	-0.1	0.4	0.3	-0.5
Reaction time trials AUC	0.0	0.1	0.2	0.2	-0.1	0.3	0.2	-0.5
Run reversals in cocaine runway, females	1.8	1.8	5.1	1.5	1.1	-0.2	-0.5	-2.3
Run reversals in cocaine runway, males	0.6	0.6	1.6	1.0	0.6	-0.2	-0.3	-1.3
Latency to leave start box in cocaine runway	0.1	0.1	0.2	0.1	0.3	-0.1	-0.1	-0.5
Latency to leave start box in cocaine runway, F	0.7	0.8	3.2	0.4	0.8	-0.2	-0.3	-1.8
Latency to leave start box in cocaine runway, M	0.6	0.5	2.1	-0.5	-0.5	-0.0	0.0	1.4
Std. dev. time between licks in bursts	0.1	0.1	0.2	-0.2	0.4	-0.4	-0.4	-0.4
Total sessions with >9 infusions	0.4	0.5	0.7	0.2	0.8	-0.7	-0.7	-0.7
Short access day 1 total inactive lever presses	0.6	0.7	2.2	1.5	0.6	0.2	0.0	-1.0
Short access day 10 total inactive lever presses	0.2	0.4	1.1	1.1	0.1	0.7	0.5	0.1
Short access day 1 total infusions	0.0	0.1	0.2	0.4	0.0	0.2	0.2	0.1
Short access day 10 total infusions	0.2	0.2	0.8	0.9	0.3	-0.3	-0.2	0.1
Short access total infusions	0.1	0.1	0.7	0.8	0.2	-0.0	0.0	0.1
Short access day 1 locomotion	0.5	0.6	1.3	1.1	0.8	-0.4	-0.4	-0.9
Short access day 10 total locomotion	0.8	1.4	4.0	2.0	1.1	-1.0	-1.0	-0.2
Short access total locomotion	0.8	1.0	2.2	1.5	1.1	-0.7	-0.8	-0.8
One hour access (0.3 mA shock)	0.8	0.9	1.1	1.0	1.0	-0.9	-0.8	-1.1
Compulsive drug intake	0.2	0.2	0.4	-0.1	-0.3	0.6	0.5	-0.6
One hour access (shock baseline)	0.6	1.0	1.3	1.0	1.1	-1.1	-1.1	-0.5
Social response proportion	1.2	1.4	2.8	0.1	1.5	-0.9	-1.1	-1.7
Social responses	0.2	0.2	0.5	0.1	0.7	-0.5	-0.5	-0.3
Social time	1.4	1.9	3.8	0.5	1.7	-1.0	-1.2	-1.9
Soleus weight	0.7	2.0	3.5	1.0	1.5	-1.2	-1.2	-1.9
Bone: stiffness	0.1	0.2	0.4	0.5	0.4	-0.3	-0.2	-0.7
Tibialis anterior weight	1.5	4.9	8.0	0.4	2.6	-2.8	-2.8	-1.4
Time to tail flick, vehicle, before self-admin	1.1	1.1	2.3	0.4	-1.0	1.5	1.5	-0.1
Time to tail flick, vehicle, after self-admin	0.3	0.4	0.9	1.0	-0.3	0.6	0.6	0.6
Time to tail flick, test, before self-admin	0.6	0.6	1.0	-0.5	1.0	-0.8	-0.9	-0.7
Time to tail flick, test, after self-admin	0.1	0.1	0.5	0.4	-0.1	0.1	0.1	0.7
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.9	0.9	0.3	-0.5	-0.4	0.8
Delta time to tail flick, test, before/after SA	0.7	0.8	2.0	0.4	-0.9	0.6	0.7	1.4
Tibia length	0.1	0.3	0.9	0.6	0.0	0.4	0.3	-0.9
Ambulatory time before self-admin	0.2	0.3	0.6	0.7	0.1	0.3	0.3	-0.8
Ambulatory time after self-admin	0.1	0.1	0.2	-0.2	-0.0	-0.0	0.0	-0.5
Bone: tissue strength	0.5	0.5	1.6	-1.2	-0.5	0.5	0.5	-0.2
Total heroin consumption	0.1	0.2	0.3	-0.0	-0.6	0.3	0.4	0.5
Bone: trabecular number	2.6	4.3	6.2	1.5	-2.1	2.4	2.5	1.6
Bone: trabecular spacing	2.5	3.3	4.9	-1.2	1.9	-2.2	-2.2	-1.3
Bone: trabecular thickness	2.6	3.2	6.8	2.6	-1.2	2.0	1.9	0.4
Bone: trabecular tissue density	1.6	2.3	4.1	-0.1	-1.7	2.0	2.0	0.8
Water consumed over 24 hours	0.1	0.1	0.3	0.5	0.1	0.2	0.1	-0.2
Number of responses in last shaping day	0.7	0.7	2.6	1.6	0.3	0.4	0.4	-0.7