Hub : Genes

LOC108351782

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	NAcc	gene expression	LOC108351782	0.04	0.03	1.9e-06	0.04	0.04	0.04	0.04	1.3e-06	3.1e-07	7.8e-07	7.2e-07
2	PL	gene expression	LOC108351782	0.03	0.02	9.9e-03	0.01	0	0.01	0	1.7e-02	1.3e-01	6.3e-02	8.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	0.0	0.0	0.0	-0.1	0.2
Area under the delay curve	1.2	1.8	1.8	1.3	-1.4
BMI with tail	0.2	0.8	0.8	-0.9	0.9
BMI without tail	0.3	1.7	2.0	-1.4	1.2
Body weight	5.6	24.6	25.3	-5.0	4.9
Weight adjusted by age	0.0	0.0	0.0	-0.0	0.1
Bone surface	0.1	0.2	0.2	0.4	-0.4
Bone volume	0.0	0.0	0.0	0.2	-0.2
Breakpoint value in progressive ratio session	0.2	0.3	0.4	0.5	-0.6
Number of licking bursts	0.1	0.2	0.2	0.4	-0.4
Context. condit. distance diff. score	0.0	0.0	0.0	0.1	-0.1
Locomotion velocity, session 1	0.2	0.2	0.4	0.2	-0.6
Locomotion distance, session 1	0.5	0.7	1.0	-1.0	0.6
Locomotion velocity, session 2	0.4	0.5	0.6	0.7	-0.7
Locomotion distance, session 2	0.0	0.1	0.1	-0.0	-0.3
Locomotion velocity, session 3	0.0	0.0	0.1	-0.3	0.1
Locomotion distance, session 3	0.7	0.8	0.9	0.9	-0.8
Stereotopy head waving bouts, day 3	0.0	0.0	0.0	-0.2	0.1
Stereotopy head waving duration, day 3	0.3	0.3	0.4	-0.6	0.5
Locomotion velocity, session 7	0.4	0.5	0.5	-0.7	0.7
Locomotion distance, session 7	0.3	0.3	0.4	0.6	-0.6
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.3	-0.4
Stereotopy head waving duration, day 7	0.1	0.1	0.1	-0.4	0.3
Locomotion velocity, session 8	0.1	0.1	0.1	-0.4	0.2
Locomotion distance, session 8	0.1	0.1	0.3	-0.5	0.2
Degree of sensitization distance	1.4	1.5	1.7	-1.3	1.1
Degree of sensitization stereotypy	0.0	0.0	0.1	0.2	-0.2
Conditioned locomotion	3.2	3.8	3.9	2.0	-1.9
Cocaine response after cond. corrected	0.2	0.3	0.4	-0.6	0.5
Cocaine response after cond. not corrected	1.3	1.8	2.1	-1.4	1.3
Cocaine response before conditioning	0.9	1.1	1.1	-1.1	1.0
Saline control response	0.8	1.1	1.2	-1.1	1.1
Bone: connectivity density	0.3	0.4	0.4	0.7	-0.6
Bone: cortical apparent density	0.3	0.5	0.6	0.8	-0.7
Bone: cortical area	0.1	0.1	0.2	0.4	-0.2
Bone: cortical porosity	0.0	0.0	0.1	0.2	-0.2
Bone: cortical porosity	0.0	0.0	0.0	0.0	-0.1
Bone: cortical thickness	0.1	0.2	0.3	-0.3	0.5
Bone: cortical thickness	0.0	0.0	0.0	-0.0	0.1
Bone: cortical tissue density	0.3	0.5	0.6	0.8	-0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.5	0.7
Condit. Reinf. active responses	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. inactive responses	0.8	1.0	1.2	1.0	-1.1
Incentive salience index mean	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. lever presses	1.2	1.8	1.9	1.3	-1.4
Condit. Reinf. active minus inactive responses	1.3	1.9	2.1	-1.3	1.5
Condit. Reinf. active-inactive response ratio	1.1	1.7	1.8	-1.3	1.3
Condit. Reinf. active responses	1.1	1.5	1.6	-1.2	1.3
Condit. Reinf. inactive responses	0.1	0.2	0.2	0.4	-0.5
Condit. Reinf. lever presses	1.9	2.8	2.8	-1.6	1.7
Condit. Reinf. lever reinforcers received	1.5	2.1	2.2	-1.4	1.5
Conditioned reinforcement - actives	0.6	2.3	3.1	1.3	-1.8
Conditioned reinforcement - inactives	1.1	2.9	3.2	1.6	-1.8
Conditioned locomotion	0.3	0.5	0.7	0.4	-0.9
Patch foraging indifference point 0 sec	0.8	2.3	2.4	-1.5	1.6
Patch foraging indifference point AUC	0.0	0.1	0.1	-0.1	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.1	-0.3	0.4
Delay disc. indifference point, 16s delay	0.7	1.0	1.1	1.0	-1.0
Delay disc. indifference point, 2s delay	0.3	0.3	0.4	0.5	-0.6
Delay disc. indifference point, 24s delay	0.9	1.4	1.7	1.0	-1.3
Delay disc. indifference point, 4s delay	1.8	1.9	2.0	1.4	-1.4
Delay disc. indifference point, 8s delay	1.0	1.7	1.8	1.3	-1.3
Indifference point function ln k	0.1	0.4	0.6	0.4	-0.8
Indifference point function log k	0.1	0.4	0.6	0.4	-0.8
Patch foraging total patch changes 0 sec	0.9	2.6	2.8	-1.6	1.7
Patch foraging total patch changes 12 sec	0.7	0.9	1.0	-0.9	1.0
Patch foraging total patch changes 18 sec	1.7	3.9	4.0	-2.0	2.0
Patch foraging total patch changes 24 sec	1.0	3.5	3.6	-1.9	1.9
Patch foraging total patch changes 6 sec	0.1	0.3	0.4	-0.4	0.6
Patch foraging time to switch 0 sec	0.2	0.6	0.8	0.7	-0.9
Patch foraging water rate 0 sec	0.1	0.5	0.6	-0.6	0.8
Patch foraging water rate 12 sec	0.1	0.4	0.4	-0.7	0.6
Patch foraging water rate 18 sec	0.2	0.4	0.5	-0.5	0.7
Patch foraging water rate 24 sec	0.9	1.3	1.6	-1.0	1.3
Patch foraging water rate 6 sec	0.3	0.5	0.5	-0.7	0.7
Seeking ratio, delayed vs. immediate footshock	0.5	0.8	1.1	1.0	-0.7
Distance traveled before self-admin	0.0	0.1	0.1	0.3	-0.1
Distance traveled after self-admin	0.4	0.8	1.1	0.7	-1.0
Extensor digitorum longus weight	0.1	0.4	0.5	0.7	-0.6
Bone: elastic displacement	0.0	0.1	0.1	-0.2	0.3
Bone: elastic work	0.3	0.4	0.4	-0.6	0.7
Bone: endosteal estimation	0.1	0.3	0.3	-0.6	0.4
Bone: endosteal perimeter	0.9	2.2	2.4	1.4	-1.6
Epididymis fat weight	0.4	1.9	2.1	-1.3	1.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	0.4	0.1
Delta time in open arm before/after self-admin	0.0	0.1	0.1	-0.3	-0.2
Diff in mean of infusions in LGA sessions	0.0	0.0	0.0	0.1	0.0
Delay discount exponential model param	1.5	2.0	2.1	-1.4	1.4
Extinction: sum of active levers before priming	0.2	0.3	0.4	-0.4	0.6
Active lever presses in extinction session 6	0.6	0.6	0.7	-0.7	0.8
Bone: final force	1.0	1.6	1.6	-1.2	1.3
Bone: final moment	1.2	1.9	2.0	-1.4	1.4
Food consumed during 24 hour testing period	1.0	2.0	2.2	-1.5	1.4
Glucose	0.8	1.3	1.5	-1.2	1.1
Heart weight	2.2	3.6	3.9	-1.8	2.0
Delay discount hyperbolic model param	1.9	2.4	2.5	-1.5	1.6
Intermittent access intake day 1-15 change	0.2	1.0	1.2	1.0	-1.1
Intermittent access intake escalation	0.3	1.6	1.8	1.2	-1.3
Intermittent access intake escalation 2	0.2	0.3	0.4	0.4	-0.7
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.1	0.4	-0.0
Intermitt. access day 15 inactive lever presses	0.5	2.6	2.9	1.7	-1.5
Intermitt. access escalation Index	0.1	0.2	0.4	-0.2	0.6
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.4	-0.2
Intermittent access day 15 total infusions	0.6	1.4	1.5	1.2	-1.2
Intermittent access terminal intake (last 3 days)	0.5	0.9	1.0	0.9	-1.0
Intermittent access total infusions	0.9	1.1	1.2	1.1	-1.0
Intermittent access day 1 locomotion	0.0	0.0	0.1	-0.3	-0.0
Intermittent access day 15 total locomotion	0.1	0.5	0.8	0.5	-0.9
Intermittent access total locomotion	0.7	0.9	1.1	0.8	-1.1
Intermittent access standard deviation	0.0	0.2	0.4	0.3	-0.6
Left kidney weight	0.4	3.5	3.9	-2.0	1.8
Right kidney weight	0.3	2.3	2.6	-1.6	1.5
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	-0.2
Post-drug Anxiety	0.1	0.2	0.3	0.2	-0.5
Baseline Anxiety	0.0	0.0	0.1	0.2	-0.1
Tail length	3.1	16.9	17.7	-4.2	4.0
Length with tail	8.7	38.7	39.1	-6.3	6.2
Length without tail	5.4	28.4	29.2	-5.3	5.4
Times rat made contact with spout	0.3	0.4	0.4	-0.6	0.6
Lifetime Intake	1.2	1.5	1.5	1.2	-1.2
Liver weight, left	0.5	0.9	1.0	-0.9	1.0
Liver weight, right	1.8	3.2	3.4	-1.7	1.8
Locomotor activity	5.7	8.8	9.6	-3.1	2.8
Locomotor testing distance	3.0	7.4	8.8	-3.0	2.4
Locomotor testing rearing	0.1	0.4	0.5	-0.7	0.5
Locomotion in novel chamber	0.1	0.1	0.1	0.4	-0.2
Locomotion in novel chamber post-restriction	0.3	0.8	0.9	-0.9	0.9
Fecal boli incidents, locomotor time 1	0.3	0.7	1.0	-0.7	1.0
Change in fecal boli incidents, locomotor task	0.0	0.0	0.0	0.0	-0.0
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.2	0.4	-0.5
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.0	-0.0
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	0.0
Rest time, locomotor task time 1	0.1	0.2	0.3	0.5	-0.3
Distance moved, locomotor task time 1	0.4	1.0	1.1	-1.0	1.0
Vertical activity count, locomotor time 1	0.1	0.4	0.4	-0.6	0.6
Time >=10cm from walls, locomotor time 2	0.6	1.8	2.2	-1.2	1.5
Bouts of movement, locomotor time 2	0.0	0.1	0.2	-0.2	0.4
Total resting periods, locomotor time 2	0.0	0.0	0.1	-0.0	0.3
Rest time, locomotor task time 2	0.0	0.0	0.0	0.0	0.0
Distance moved, locomotor task time 2	0.5	0.6	0.6	-0.8	0.8
Vertical activity count, locomotor time 2	0.0	0.0	0.0	-0.0	-0.1
Light reinforcement 1	0.2	0.7	0.8	-0.9	0.7
Light reinforcement 2	0.0	0.1	0.1	0.3	-0.1
Bone: marrow area	0.1	0.3	0.3	-0.6	0.5
Bone: maximum diameter	0.4	0.7	0.8	0.8	-0.9
Bone: maximum force	0.7	1.3	1.4	-1.1	1.2
Bone: maximum moment	0.8	1.5	1.5	-1.2	1.2
Mean time between licks in bursts	0.2	1.5	1.6	1.2	-1.3
Mean num. licks in bursts	0.3	0.7	0.7	-0.8	0.8
Cd content in liver	0.1	0.1	0.1	0.2	-0.3
Co content in liver	0.9	1.1	1.3	1.1	-0.9
Cu content in liver	3.8	4.5	4.6	-2.2	2.1
Fe content in liver	1.1	1.3	1.6	-1.0	1.3
K content in liver	0.0	0.0	0.0	-0.1	0.2
Mg content in liver	1.1	1.2	1.2	1.1	-1.1
Mn content in liver	0.0	0.0	0.0	0.1	-0.1
Na content in liver	0.3	0.3	0.4	-0.4	0.6
Rb content in liver	0.9	1.1	1.4	-0.9	1.2
Se content in liver	0.0	0.0	0.0	0.2	-0.1
Sr content in liver	0.1	0.1	0.2	0.1	-0.4
Zn content in liver	2.2	2.6	2.7	-1.6	1.6
Bone: minimum diameter	0.3	0.5	0.5	0.7	-0.7
Time in familiar zone, hab. session 1	0.8	0.9	1.0	1.0	-0.9
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	0.2
Total zone transitions, hab. session 1	0.4	0.6	0.9	-1.0	0.5
Total locomotion distance, hab. session 1	0.2	0.3	0.3	-0.6	0.5
Locomotion velocity, hab. session 1	0.2	0.3	0.3	-0.6	0.5
Time in familiar zone, hab. session 2	0.4	0.5	0.6	0.8	-0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	-0.3	0.2
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.3	0.0
Total locomotion distance, hab. session 2	0.2	0.2	0.2	-0.5	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.1	-0.3	0.3
Novel to familiar place preference ratio	1.0	1.4	1.4	-1.2	1.2
Novelty place preference	1.0	1.3	1.4	-1.2	1.1
Time in novel zone, NPP test	1.4	1.7	1.7	-1.3	1.3
Total zone transitions, NPP test	2.0	3.0	3.8	-1.9	1.5
Total locomotion distance, NPP test	0.9	1.3	1.3	-1.1	1.1
Locomotion velocity, NPP test	0.9	1.3	1.3	-1.2	1.2
Intraocular pressure	1.0	1.6	1.7	-1.3	1.3
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.1	-0.4
Delta ambulatory time before/after self-admin	0.1	0.3	0.5	-0.7	0.2
Parametrial fat weight	0.3	0.8	0.9	-0.9	0.8
Pavlov. Cond. lever latency	4.1	5.2	5.7	-2.4	2.2
Pavlov. Cond. magazine entry latency	8.0	10.2	10.3	3.2	-3.2
Pavlov. Cond. change in total contacts	1.3	1.4	1.8	1.3	-1.0
Pavlov. Cond. index score	6.5	8.3	8.7	3.0	-2.8
Pavlov. Cond. latency score	6.3	8.0	8.4	2.9	-2.7
Pavlov. Cond. lever contacts	2.6	3.1	3.4	1.8	-1.7
Pavlov. Cond. magazine entry number	7.7	9.8	10.0	-3.2	3.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.8	0.7
Pavlov. Cond. lever-magazine prob. diff.	5.9	7.4	7.8	2.8	-2.6
Pavlov. Cond. response bias	6.9	8.5	8.8	3.0	-2.9
Pavlov. Cond. lever latency	0.7	1.0	1.0	1.0	-1.0
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	0.3	-0.4
Pavlov. Cond. change in total contacts	1.5	3.6	3.7	-1.9	1.9
Pavlov. Cond. index score	0.2	0.3	0.3	-0.5	0.5
Pavlov. Cond. latency score	0.1	0.1	0.1	-0.4	0.3
Pavlov. Cond. lever contacts	0.9	1.4	1.4	-1.2	1.2
Pavlov. Cond. magazine entry number	0.1	0.1	0.1	-0.3	0.4
Pavlov. Cond. intertrial magazine entries	0.3	0.7	0.8	0.9	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.2	-0.4	0.4
Pavlov. Cond. response bias	0.1	0.2	0.2	-0.4	0.4
Time in closed arm before self-admin	0.7	1.3	1.8	-1.3	0.9
Time in closed arm after self-admin	0.0	0.0	0.0	0.0	0.0
Time in open arm before self-admin	0.6	0.7	1.0	1.0	-0.6
Time in open arm after self-admin	0.5	0.6	0.9	0.6	-0.9
Bone: periosteal estimation	0.0	0.1	0.1	-0.2	0.2
Bone: periosteal perimeter	0.7	1.4	1.5	1.2	-1.2
Bone: post-yield work	0.0	0.0	0.1	-0.3	0.1
Progressive ratio test 1 active lever presses	0.0	0.0	0.1	-0.2	0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.0	-0.2	0.2
Progressive ratio test 1 inactive lever presses	0.2	0.6	0.8	0.6	-0.9
Progressive ratio test 2 active lever presses	1.5	2.1	2.1	1.5	-1.5
Progressive ratio test 2 breakpoint	1.7	2.2	2.2	1.5	-1.5
Progressive ratio test 2 inactive lever presses	1.0	3.1	3.2	1.7	-1.8
Incentive Sensitization - Responses	1.0	2.8	3.1	1.8	-1.6
Incentive Sensitization - Breakpoint	1.3	2.9	3.1	1.8	-1.6
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	0.1	-0.3
Progressive ratio	1.6	4.6	4.6	-2.1	2.1
Food seeking constrained by brief footshock	0.6	0.7	0.9	1.0	-0.7
Seeking ratio, punishment vs. effort	2.7	5.9	6.5	2.5	-2.3
Retroperitoneal fat weight	1.3	5.7	5.7	-2.4	2.4
Reaction time number correct	0.1	0.4	0.6	0.5	-0.8
Reaction time mean minus median	0.0	0.0	0.0	-0.1	-0.1
Reaction time mean minus median AUC	0.0	0.2	0.3	-0.6	0.4
Reaction time num false alarms	0.1	0.2	0.3	0.3	-0.5
Reaction time num false alarms AUC	0.0	0.0	0.1	0.1	-0.3
Reaction time trials correct on left	0.1	0.4	0.6	0.5	-0.8
Reaction time trials on left	0.1	0.5	0.7	0.5	-0.8
Reaction time mean	0.0	0.0	0.0	-0.1	-0.0
Reaction time mean AUC	0.0	0.0	0.0	-0.1	-0.0
Median of all reaction times	0.0	0.0	0.0	0.0	0.0
Reaction time omissions	0.1	0.2	0.3	0.4	-0.5
Reaction time false alarm rate	0.0	0.0	0.0	-0.0	-0.0
Reaction time premature initiation rate	0.8	1.2	1.4	-1.2	1.0
Reaction time premature initiations	0.1	0.4	0.6	-0.8	0.5
Std. dev. reaction times	0.0	0.1	0.2	-0.4	0.2
Reaction time trials completed	0.1	0.5	0.7	0.5	-0.8
Reaction time trials AUC	0.2	0.5	0.7	0.6	-0.9
Run reversals in cocaine runway, females	1.0	1.1	1.4	1.2	-0.9
Run reversals in cocaine runway, males	0.1	0.1	0.1	-0.2	-0.3
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	-0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.5	0.1
Latency to leave start box in cocaine runway, M	0.7	0.7	0.9	1.0	-0.7
Std. dev. time between licks in bursts	2.0	3.8	3.8	2.0	-1.9
Total sessions with >9 infusions	0.4	0.5	0.5	0.7	-0.7
Short access day 1 total inactive lever presses	1.2	2.4	2.9	1.7	-1.4
Short access day 10 total inactive lever presses	0.0	0.0	0.0	-0.1	0.2
Short access day 1 total infusions	1.6	3.1	3.5	1.9	-1.7
Short access day 10 total infusions	0.8	1.3	1.7	1.3	-0.9
Short access total infusions	2.0	2.9	3.0	1.7	-1.7
Short access day 1 locomotion	0.4	0.6	0.7	0.7	-0.9
Short access day 10 total locomotion	0.0	0.2	0.2	-0.4	0.4
Short access total locomotion	0.0	0.0	0.1	0.1	-0.3
One hour access (0.3 mA shock)	0.2	0.2	0.3	0.3	-0.6
Compulsive drug intake	0.5	0.7	0.8	0.8	-0.9
One hour access (shock baseline)	0.1	0.3	0.4	0.4	-0.6
Social response proportion	0.0	0.1	0.1	-0.3	0.1
Social responses	0.2	0.3	0.4	-0.6	0.5
Social time	1.2	1.9	2.6	1.1	-1.6
Soleus weight	4.3	12.8	13.1	-3.6	3.5
Bone: stiffness	0.1	0.3	0.3	-0.5	0.5
Tibialis anterior weight	0.0	0.1	0.2	-0.3	0.4
Time to tail flick, vehicle, before self-admin	2.2	2.7	3.0	-1.6	1.7
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.0	-0.0	-0.2
Time to tail flick, test, before self-admin	0.0	0.0	0.0	0.2	-0.1
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	1.2	1.3	1.5	1.0	-1.2
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.0	0.0
Tibia length	6.5	18.0	18.8	-4.3	4.1
Ambulatory time before self-admin	0.1	0.2	0.4	0.6	-0.2
Ambulatory time after self-admin	0.1	0.1	0.2	0.3	-0.4
Bone: tissue strength	3.2	3.4	3.7	-1.7	1.9
Total heroin consumption	1.2	1.4	1.6	-1.2	1.1
Bone: trabecular number	0.4	0.8	0.9	0.9	-0.9
Bone: trabecular spacing	1.2	1.7	1.7	-1.3	1.3
Bone: trabecular thickness	0.0	0.0	0.0	-0.1	0.2
Bone: trabecular tissue density	0.1	0.2	0.4	-0.6	0.3
Water consumed over 24 hours	0.0	0.0	0.0	-0.1	0.1
Number of responses in last shaping day	0.1	0.1	0.1	0.3	0.3