Hub : Genes

LOC108351781

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	RMTg	gene expression	LOC108351781	0.18	0.16	2.4e-03	0.07	0.06	0.03	0.06	5.1e-03	8.5e-03	6.2e-02	9.9e-03
2	Brain	gene expression	LOC108351781	0.05	0.09	8.0e-03	0.02	0.01	0.01	0.01	1.1e-02	5.7e-02	3.9e-02	2.3e-02
3	Adipose	mRNA stability	LOC108351781	0.08	0.05	1.5e-10	0.07	0.09	0.09	0.08	1.0e-08	4.2e-10	7.1e-10	1.6e-09
4	Brain	mRNA stability	LOC108351781	0.07	0.09	9.1e-04	0.03	0.03	0.02	0.03	1.3e-03	1.7e-03	3.3e-03	1.9e-03
5	Adipose	gene expression	LOC108351781	0.13	0.08	1.1e-15	0.13	0.12	0.12	0.13	1.3e-14	9.7e-14	9.5e-14	2.4e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bone: apparent density	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	-0.2
Area under the delay curve	2.5	2.6	3.4	1.5	1.5	-1.6	1.9	1.5
BMI with tail	0.4	1.3	2.4	-1.6	-1.4	1.0	-0.8	-0.7
BMI without tail	1.7	3.4	4.3	-2.0	-2.1	1.9	-1.7	-1.6
Body weight	6.8	28.4	31.4	-5.6	-5.5	5.3	-5.1	-5.1
Weight adjusted by age	0.2	0.3	0.4	-0.5	-0.5	0.5	-0.6	-0.5
Bone surface	0.0	0.1	0.1	0.2	0.1	-0.3	0.3	0.3
Bone volume	0.0	0.0	0.0	-0.0	-0.0	-0.1	0.1	0.2
Breakpoint value in progressive ratio session	0.0	0.0	0.1	-0.3	-0.1	0.3	-0.3	-0.1
Number of licking bursts	0.1	0.1	0.2	0.4	0.4	-0.4	0.3	0.3
Context. condit. distance diff. score	0.0	0.0	0.0	-0.0	-0.1	0.0	-0.0	-0.0
Locomotion velocity, session 1	0.0	0.0	0.1	0.1	0.1	-0.3	0.2	0.2
Locomotion distance, session 1	1.0	1.2	1.7	-1.3	-1.3	1.0	-1.0	-1.0
Locomotion velocity, session 2	0.2	0.3	0.4	0.3	0.4	-0.6	0.6	0.6
Locomotion distance, session 2	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	0.1
Locomotion velocity, session 3	0.1	0.1	0.2	-0.4	-0.5	0.2	-0.2	-0.1
Locomotion distance, session 3	0.9	1.0	1.3	0.8	0.8	-1.1	1.1	1.2
Stereotopy head waving bouts, day 3	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.3	-0.2
Stereotopy head waving duration, day 3	0.3	0.4	0.5	-0.5	-0.5	0.6	-0.7	-0.7
Locomotion velocity, session 7	0.4	0.4	0.5	-0.6	-0.7	0.6	-0.6	-0.6
Locomotion distance, session 7	0.5	0.6	0.7	0.7	0.7	-0.8	0.8	0.8
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	0.4	0.3	-0.3	0.4	0.3
Stereotopy head waving duration, day 7	0.2	0.2	0.2	-0.4	-0.5	0.5	-0.4	-0.4
Locomotion velocity, session 8	0.3	0.3	0.7	-0.7	-0.8	0.4	-0.4	-0.4
Locomotion distance, session 8	0.3	0.4	0.8	-0.8	-0.9	0.5	-0.4	-0.4
Degree of sensitization distance	1.4	1.4	1.7	-1.1	-1.1	1.2	-1.2	-1.3
Degree of sensitization stereotypy	0.0	0.0	0.0	0.1	0.0	0.0	0.2	0.1
Conditioned locomotion	3.3	3.9	4.3	2.1	2.1	-1.9	1.9	1.9
Cocaine response after cond. corrected	0.2	0.2	0.3	-0.6	-0.5	0.5	-0.5	-0.4
Cocaine response after cond. not corrected	1.8	2.0	2.3	-1.5	-1.5	1.4	-1.4	-1.3
Cocaine response before conditioning	1.2	1.5	1.7	-1.3	-1.3	1.1	-1.1	-1.1
Saline control response	1.3	1.7	2.0	-1.2	-1.2	1.4	-1.4	-1.4
Bone: connectivity density	0.2	0.3	0.4	0.7	0.6	-0.5	0.5	0.6
Bone: cortical apparent density	0.3	0.4	0.5	0.7	0.7	-0.6	0.6	0.6
Bone: cortical area	0.1	0.1	0.2	0.4	0.3	-0.4	0.3	0.3
Bone: cortical porosity	0.0	0.1	0.1	0.3	0.3	-0.1	0.1	0.1
Bone: cortical porosity	0.2	0.2	0.3	0.5	0.6	-0.3	0.3	0.3
Bone: cortical thickness	0.1	0.2	0.2	-0.4	-0.4	0.4	-0.4	-0.4
Bone: cortical thickness	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.1	-0.1
Bone: cortical tissue density	0.3	0.4	0.5	0.7	0.7	-0.6	0.7	0.7
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	-0.2	0.4	-0.4	-0.4
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.4	-0.4	-0.4	0.6	-0.6	-0.6
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	0.3	-0.1	0.2	0.2
Condit. Reinf. inactive responses	0.9	1.0	1.3	1.0	1.0	-0.9	1.0	1.1
Incentive salience index mean	0.0	0.1	0.1	0.3	0.3	-0.2	0.2	0.2
Condit. Reinf. lever presses	1.4	1.9	2.2	1.3	1.3	-1.5	1.4	1.4
Condit. Reinf. active minus inactive responses	2.4	3.0	3.6	-1.9	-1.8	1.6	-1.6	-1.7
Condit. Reinf. active-inactive response ratio	1.8	1.9	2.4	-1.6	-1.4	1.3	-1.2	-1.3
Condit. Reinf. active responses	1.9	2.6	3.0	-1.7	-1.6	1.6	-1.6	-1.6
Condit. Reinf. inactive responses	0.0	0.0	0.0	0.2	0.2	-0.1	-0.0	0.1
Condit. Reinf. lever presses	2.6	3.6	4.3	-2.1	-2.0	1.8	-1.8	-1.8
Condit. Reinf. lever reinforcers received	2.2	3.1	3.5	-1.9	-1.7	1.7	-1.7	-1.7
Conditioned reinforcement - actives	0.4	0.4	0.6	0.8	0.7	-0.5	0.3	0.7
Conditioned reinforcement - inactives	0.9	1.0	1.0	1.0	1.0	-1.0	1.0	1.0
Conditioned locomotion	0.5	0.6	0.8	0.9	0.8	-0.7	0.5	0.8
Patch foraging indifference point 0 sec	1.2	2.0	2.3	-1.5	-1.3	1.3	-1.4	-1.5
Patch foraging indifference point AUC	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.1	0.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	0.1	0.2	-0.2	0.4	0.2
Delay disc. indifference point, 16s delay	1.0	1.0	1.2	1.0	1.0	-1.1	1.1	1.0
Delay disc. indifference point, 2s delay	0.5	0.5	1.1	0.6	0.7	-0.6	1.0	0.7
Delay disc. indifference point, 24s delay	1.0	0.9	1.2	0.9	0.9	-0.9	1.1	0.9
Delay disc. indifference point, 4s delay	2.5	2.7	3.5	1.6	1.6	-1.6	1.9	1.6
Delay disc. indifference point, 8s delay	2.4	2.5	3.2	1.5	1.5	-1.5	1.8	1.5
Indifference point function ln k	0.1	0.1	0.2	0.1	0.2	-0.5	0.3	0.3
Indifference point function log k	0.1	0.1	0.2	0.1	0.2	-0.5	0.3	0.3
Patch foraging total patch changes 0 sec	1.5	2.3	2.7	-1.6	-1.4	1.4	-1.5	-1.7
Patch foraging total patch changes 12 sec	0.9	1.1	1.4	-1.1	-1.0	1.1	-0.9	-1.2
Patch foraging total patch changes 18 sec	2.5	3.3	4.0	-1.7	-1.6	1.9	-2.0	-1.8
Patch foraging total patch changes 24 sec	3.1	3.8	4.2	-2.0	-2.0	2.0	-1.8	-2.0
Patch foraging total patch changes 6 sec	0.1	0.2	0.3	-0.4	-0.3	0.4	-0.3	-0.5
Patch foraging time to switch 0 sec	0.1	0.2	0.2	0.4	0.5	-0.4	0.5	0.3
Patch foraging water rate 0 sec	0.2	0.3	0.4	-0.5	-0.5	0.5	-0.6	-0.5
Patch foraging water rate 12 sec	0.4	0.6	0.9	-0.8	-0.9	0.7	-0.7	-0.8
Patch foraging water rate 18 sec	0.0	0.1	0.2	-0.3	-0.5	0.1	-0.0	-0.1
Patch foraging water rate 24 sec	0.6	0.9	1.0	-0.9	-0.9	1.0	-1.0	-0.8
Patch foraging water rate 6 sec	0.4	0.6	0.9	-0.8	-0.9	0.6	-0.7	-0.8
Seeking ratio, delayed vs. immediate footshock	2.5	2.9	3.1	1.6	1.7	-1.7	1.8	1.7
Distance traveled before self-admin	0.0	0.0	0.1	-0.1	-0.3	0.1	-0.1	-0.3
Distance traveled after self-admin	0.1	0.1	0.2	0.4	0.1	-0.4	0.3	0.1
Extensor digitorum longus weight	0.1	0.6	0.7	0.7	0.8	-0.8	0.8	0.7
Bone: elastic displacement	0.1	0.1	0.1	-0.2	-0.2	0.2	-0.3	-0.3
Bone: elastic work	0.6	0.8	1.0	-1.0	-1.0	0.8	-0.8	-0.8
Bone: endosteal estimation	0.1	0.3	0.3	-0.5	-0.5	0.5	-0.5	-0.6
Bone: endosteal perimeter	1.0	2.2	2.4	1.5	1.4	-1.6	1.5	1.4
Epididymis fat weight	0.2	0.4	0.6	-0.7	-0.5	0.8	-0.6	-0.5
Delta time in closed arm before/after self-admin	0.1	0.1	0.1	0.3	0.4	-0.4	0.2	0.4
Delta time in open arm before/after self-admin	0.4	0.3	0.4	-0.5	-0.6	0.5	-0.6	-0.6
Diff in mean of infusions in LGA sessions	0.0	0.0	0.1	0.2	0.3	-0.1	0.0	0.3
Delay discount exponential model param	2.9	3.1	4.1	-1.7	-1.7	1.7	-2.0	-1.7
Extinction: sum of active levers before priming	0.0	0.0	0.0	-0.1	0.0	0.1	-0.2	-0.0
Active lever presses in extinction session 6	0.3	0.3	0.4	-0.5	-0.4	0.6	-0.6	-0.4
Bone: final force	0.9	1.4	1.6	-1.2	-1.3	1.1	-1.1	-1.2
Bone: final moment	1.2	1.9	2.1	-1.4	-1.5	1.3	-1.3	-1.4
Food consumed during 24 hour testing period	1.5	1.8	2.0	-1.4	-1.4	1.3	-1.3	-1.3
Glucose	0.3	0.4	0.5	-0.7	-0.7	0.6	-0.5	-0.5
Heart weight	2.7	3.9	4.4	-2.0	-2.1	1.9	-1.8	-2.0
Delay discount hyperbolic model param	2.9	3.1	4.2	-1.7	-1.7	1.7	-2.0	-1.7
Intermittent access intake day 1-15 change	0.6	0.6	0.7	0.8	0.8	-0.7	0.6	0.8
Intermittent access intake escalation	0.4	0.4	0.5	0.7	0.7	-0.6	0.5	0.7
Intermittent access intake escalation 2	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.3	-0.1
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.0	-0.0	0.0	-0.1	0.1	0.0
Intermitt. access day 15 inactive lever presses	0.7	0.7	1.0	0.8	0.8	-0.9	1.0	0.8
Intermitt. access escalation Index	0.0	0.0	0.0	-0.1	-0.0	0.0	-0.1	-0.0
Intermittent access day 1 total infusions	0.0	0.0	0.0	0.2	0.2	-0.1	0.0	0.2
Intermittent access day 15 total infusions	0.3	0.3	0.4	0.7	0.7	-0.5	0.4	0.7
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	0.5	0.5	-0.3	0.1	0.5
Intermittent access total infusions	0.5	0.5	0.6	0.8	0.8	-0.7	0.4	0.8
Intermittent access day 1 locomotion	0.1	0.1	0.2	0.4	0.3	-0.3	0.2	0.3
Intermittent access day 15 total locomotion	0.5	0.6	0.7	0.9	0.8	-0.7	0.6	0.8
Intermittent access total locomotion	1.3	1.4	1.7	1.3	1.2	-1.1	1.0	1.2
Intermittent access standard deviation	0.2	0.2	0.4	-0.4	-0.4	0.5	-0.6	-0.4
Left kidney weight	0.7	1.9	2.9	-1.6	-1.7	1.3	-1.1	-1.2
Right kidney weight	0.1	0.3	0.6	-0.7	-0.8	0.6	-0.4	-0.4
Cocaine induced anxiety	0.6	0.7	0.8	0.8	0.8	-0.8	0.9	0.8
Post-drug Anxiety	0.2	0.3	0.4	0.4	0.4	-0.5	0.7	0.4
Baseline Anxiety	0.1	0.1	0.1	0.3	0.3	-0.4	0.4	0.3
Tail length	6.8	20.5	21.9	-4.3	-4.5	4.7	-4.6	-4.5
Length with tail	9.8	35.8	36.5	-5.9	-6.0	6.0	-6.0	-6.0
Length without tail	6.7	14.7	15.5	-3.9	-3.8	3.8	-3.8	-3.8
Times rat made contact with spout	0.3	0.3	0.5	-0.6	-0.4	0.7	-0.6	-0.5
Lifetime Intake	0.3	0.4	0.5	0.7	0.7	-0.6	0.4	0.7
Liver weight, left	0.0	0.0	0.1	0.0	0.0	0.3	-0.2	-0.2
Liver weight, right	1.0	1.7	2.0	-1.4	-1.3	1.4	-1.2	-1.2
Locomotor activity	6.4	10.1	11.8	-2.9	-3.2	3.1	-3.4	-3.1
Locomotor testing distance	6.3	10.4	11.9	-3.2	-3.2	3.2	-3.5	-3.1
Locomotor testing rearing	0.4	0.6	1.1	-0.7	-0.7	0.7	-1.1	-0.8
Locomotion in novel chamber	0.2	0.2	0.3	0.5	0.5	-0.5	0.5	0.5
Locomotion in novel chamber post-restriction	0.7	0.8	1.0	-0.9	-0.9	1.0	-0.9	-0.9
Fecal boli incidents, locomotor time 1	0.4	0.4	0.5	-0.7	-0.7	0.7	-0.5	-0.7
Change in fecal boli incidents, locomotor task	0.0	0.0	0.1	-0.2	-0.1	0.2	-0.3	-0.1
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.4	0.3	-0.3	0.3	0.3
Bouts of movement, locomotor time 1	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	-0.1
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.0	-0.1	0.1	-0.1	-0.1
Rest time, locomotor task time 1	0.7	0.7	0.9	1.0	0.8	-0.8	0.9	0.8
Distance moved, locomotor task time 1	1.8	2.0	2.2	-1.4	-1.4	1.4	-1.5	-1.4
Vertical activity count, locomotor time 1	0.9	1.0	1.4	-1.0	-0.9	0.9	-1.2	-0.9
Time >=10cm from walls, locomotor time 2	1.5	1.6	1.7	-1.3	-1.3	1.3	-1.2	-1.3
Bouts of movement, locomotor time 2	0.0	0.0	0.0	-0.2	-0.1	0.1	0.1	-0.1
Total resting periods, locomotor time 2	0.0	0.0	0.1	0.1	0.2	-0.2	0.3	0.2
Rest time, locomotor task time 2	0.0	0.0	0.1	0.3	0.1	-0.2	0.2	0.1
Distance moved, locomotor task time 2	0.8	1.0	1.1	-1.0	-1.1	1.0	-0.8	-1.1
Vertical activity count, locomotor time 2	0.1	0.1	0.1	-0.3	-0.2	0.2	-0.2	-0.2
Light reinforcement 1	0.6	1.2	1.5	-1.2	-1.2	1.1	-0.9	-1.0
Light reinforcement 2	0.1	0.1	0.2	0.1	0.0	-0.4	0.5	0.3
Bone: marrow area	0.1	0.3	0.4	-0.5	-0.5	0.5	-0.6	-0.6
Bone: maximum diameter	0.4	0.7	0.8	0.8	0.8	-0.9	0.8	0.8
Bone: maximum force	0.8	1.3	1.4	-1.1	-1.2	1.1	-1.1	-1.2
Bone: maximum moment	0.9	1.5	1.6	-1.2	-1.3	1.2	-1.2	-1.3
Mean time between licks in bursts	0.8	1.2	1.6	1.0	1.0	-1.3	1.1	1.1
Mean num. licks in bursts	0.4	0.5	0.7	-0.7	-0.7	0.8	-0.7	-0.6
Cd content in liver	2.5	2.8	3.4	-1.5	-1.4	1.7	-1.8	-1.8
Co content in liver	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.3	-0.3
Cu content in liver	4.2	5.1	5.2	-2.2	-2.2	2.3	-2.3	-2.3
Fe content in liver	1.7	2.0	2.7	-1.1	-1.1	1.5	-1.6	-1.6
K content in liver	0.7	0.6	0.9	-0.9	-0.9	0.8	-0.7	-0.7
Mg content in liver	0.0	0.0	0.0	-0.2	-0.2	-0.1	0.1	0.1
Mn content in liver	0.7	0.8	1.1	-1.0	-1.0	0.8	-0.8	-0.8
Na content in liver	0.3	0.3	0.4	-0.4	-0.4	0.7	-0.6	-0.6
Rb content in liver	1.3	1.6	2.5	-0.8	-0.8	1.3	-1.6	-1.6
Se content in liver	0.0	0.0	0.0	-0.2	-0.1	0.1	0.2	0.2
Sr content in liver	0.1	0.0	0.1	-0.3	-0.3	-0.0	0.1	0.1
Zn content in liver	4.8	5.3	5.7	-2.4	-2.4	2.2	-2.3	-2.3
Bone: minimum diameter	0.3	0.5	0.6	0.7	0.6	-0.8	0.7	0.7
Time in familiar zone, hab. session 1	1.2	1.2	1.6	1.2	1.3	-1.0	0.9	0.9
Time in novel zone, hab. session 1	0.5	0.5	0.6	-0.7	-0.8	0.7	-0.5	-0.6
Total zone transitions, hab. session 1	0.6	0.9	1.3	-1.1	-1.1	0.8	-0.7	-0.8
Total locomotion distance, hab. session 1	0.2	0.3	0.4	-0.6	-0.6	0.5	-0.4	-0.4
Locomotion velocity, hab. session 1	0.2	0.3	0.4	-0.6	-0.6	0.5	-0.5	-0.4
Time in familiar zone, hab. session 2	0.4	0.4	0.5	0.7	0.7	-0.7	0.5	0.6
Time in novel zone, hab. session 2	0.0	0.0	0.1	-0.2	-0.2	0.2	-0.2	-0.2
Total zone transitions, hab. session 2	0.1	0.2	0.3	-0.6	-0.6	0.2	-0.1	-0.2
Total locomotion distance, hab. session 2	0.2	0.3	0.5	-0.7	-0.7	0.5	-0.4	-0.4
Locomotion velocity, hab. session 2	0.1	0.2	0.3	-0.5	-0.5	0.4	-0.3	-0.3
Novel to familiar place preference ratio	1.0	1.0	1.2	-1.0	-1.1	0.9	-1.0	-1.0
Novelty place preference	1.0	1.0	1.1	-1.0	-1.1	0.9	-0.9	-1.0
Time in novel zone, NPP test	1.3	1.3	1.4	-1.1	-1.2	1.1	-1.1	-1.2
Total zone transitions, NPP test	2.4	3.4	4.7	-2.2	-2.1	1.7	-1.6	-1.5
Total locomotion distance, NPP test	0.9	1.2	1.6	-1.3	-1.2	1.1	-1.0	-0.9
Locomotion velocity, NPP test	0.9	1.3	1.8	-1.3	-1.3	1.1	-1.0	-1.0
Intraocular pressure	1.0	1.5	2.1	-1.0	-1.0	1.3	-1.4	-1.3
Delta distance traveled before/after self-admin	0.1	0.1	0.2	0.3	0.2	-0.5	0.4	0.2
Delta ambulatory time before/after self-admin	0.4	0.4	0.5	-0.6	-0.7	0.5	-0.7	-0.7
Parametrial fat weight	1.0	2.0	2.2	-1.4	-1.5	1.4	-1.3	-1.4
Pavlov. Cond. lever latency	5.4	6.8	7.4	-2.5	-2.5	2.7	-2.6	-2.7
Pavlov. Cond. magazine entry latency	6.5	8.3	8.9	2.8	2.8	-3.0	2.9	2.9
Pavlov. Cond. change in total contacts	1.6	1.8	2.0	1.4	1.3	-1.4	1.2	1.3
Pavlov. Cond. index score	6.4	8.2	8.8	2.8	2.8	-3.0	2.8	2.9
Pavlov. Cond. latency score	6.3	8.0	8.6	2.8	2.8	-2.9	2.8	2.9
Pavlov. Cond. lever contacts	3.1	3.7	4.0	1.8	1.8	-2.0	1.9	2.0
Pavlov. Cond. magazine entry number	7.4	9.2	9.8	-3.0	-3.0	3.1	-3.0	-3.0
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.7	-0.7	0.7	-0.8	-0.7
Pavlov. Cond. lever-magazine prob. diff.	5.7	7.1	7.6	2.6	2.6	-2.8	2.6	2.7
Pavlov. Cond. response bias	7.1	8.6	9.2	2.9	2.9	-3.0	2.9	3.0
Pavlov. Cond. lever latency	0.6	0.8	1.2	1.1	1.0	-0.7	0.8	0.8
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.0	0.0	-0.4	0.3	0.4
Pavlov. Cond. change in total contacts	2.9	4.0	4.9	-2.2	-2.1	1.9	-1.9	-1.9
Pavlov. Cond. index score	0.2	0.2	0.5	-0.7	-0.6	0.3	-0.3	-0.3
Pavlov. Cond. latency score	0.1	0.1	0.4	-0.6	-0.5	0.2	-0.2	-0.2
Pavlov. Cond. lever contacts	1.2	1.6	2.2	-1.5	-1.4	1.1	-1.1	-1.2
Pavlov. Cond. magazine entry number	0.2	0.3	0.4	-0.2	-0.4	0.7	-0.6	-0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.0	1.0	0.8	-0.6	0.5	0.5
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.2	0.5	-0.7	-0.6	0.2	-0.2	-0.2
Pavlov. Cond. response bias	0.2	0.2	0.5	-0.7	-0.5	0.2	-0.3	-0.3
Time in closed arm before self-admin	1.6	1.8	2.0	-1.3	-1.3	1.4	-1.4	-1.3
Time in closed arm after self-admin	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.2	-0.1
Time in open arm before self-admin	1.3	1.4	1.6	1.1	1.3	-1.2	1.2	1.3
Time in open arm after self-admin	0.2	0.2	0.2	0.4	0.4	-0.4	0.4	0.4
Bone: periosteal estimation	0.0	0.1	0.1	-0.2	-0.3	0.2	-0.2	-0.3
Bone: periosteal perimeter	1.1	1.8	2.0	1.3	1.3	-1.4	1.3	1.3
Bone: post-yield work	0.1	0.1	0.1	-0.3	-0.3	0.2	-0.2	-0.3
Progressive ratio test 1 active lever presses	0.0	0.0	0.0	0.2	0.2	-0.0	-0.1	0.2
Progressive ratio test 1 breakpoint	0.0	0.0	0.1	0.3	0.2	-0.1	0.0	0.2
Progressive ratio test 1 inactive lever presses	0.4	0.4	0.5	0.7	0.7	-0.6	0.6	0.7
Progressive ratio test 2 active lever presses	1.0	1.1	1.2	1.1	1.1	-1.0	0.9	1.1
Progressive ratio test 2 breakpoint	0.8	0.9	1.1	1.0	1.0	-0.9	0.8	1.0
Progressive ratio test 2 inactive lever presses	2.1	2.4	2.6	1.6	1.6	-1.6	1.4	1.6
Incentive Sensitization - Responses	1.8	1.8	1.9	1.3	1.4	-1.4	1.3	1.4
Incentive Sensitization - Breakpoint	1.7	1.8	1.8	1.3	1.4	-1.3	1.3	1.4
Sum of active levers in priming session hrs 5-6	0.4	0.4	0.5	-0.6	-0.5	0.7	-0.7	-0.5
Progressive ratio	3.7	4.3	4.6	-2.0	-2.1	2.0	-2.0	-2.1
Food seeking constrained by brief footshock	0.7	0.9	1.0	1.0	0.9	-1.0	0.9	0.9
Seeking ratio, punishment vs. effort	5.6	6.8	7.0	2.6	2.7	-2.6	2.5	2.7
Retroperitoneal fat weight	0.6	1.9	2.1	-1.4	-1.4	1.4	-1.2	-1.4
Reaction time number correct	0.3	0.4	0.7	0.8	0.6	-0.6	0.5	0.5
Reaction time mean minus median	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.2	0.0
Reaction time mean minus median AUC	0.2	0.2	0.3	-0.4	-0.5	0.5	-0.5	-0.4
Reaction time num false alarms	0.2	0.3	0.5	0.7	0.6	-0.6	0.3	0.5
Reaction time num false alarms AUC	0.1	0.1	0.2	0.5	0.3	-0.2	0.0	0.1
Reaction time trials correct on left	0.3	0.4	0.7	0.8	0.6	-0.6	0.5	0.5
Reaction time trials on left	0.3	0.4	0.7	0.9	0.7	-0.7	0.5	0.5
Reaction time mean	0.0	0.0	0.1	-0.0	0.1	0.1	-0.3	0.1
Reaction time mean AUC	0.0	0.0	0.0	0.1	0.2	0.0	-0.2	0.2
Median of all reaction times	0.0	0.0	0.1	0.1	0.1	0.1	-0.3	0.0
Reaction time omissions	0.4	0.5	0.9	0.9	1.0	-0.5	0.5	0.6
Reaction time false alarm rate	0.0	0.0	0.0	0.2	0.2	-0.1	0.0	0.1
Reaction time premature initiation rate	1.9	2.6	3.0	-1.6	-1.6	1.7	-1.7	-1.5
Reaction time premature initiations	0.9	1.3	1.6	-1.1	-1.1	1.2	-1.3	-1.1
Std. dev. reaction times	0.1	0.1	0.3	-0.2	-0.1	0.4	-0.6	-0.1
Reaction time trials completed	0.3	0.4	0.7	0.9	0.7	-0.7	0.5	0.5
Reaction time trials AUC	0.4	0.6	0.9	1.0	0.7	-0.7	0.6	0.6
Run reversals in cocaine runway, females	2.2	2.1	2.3	1.5	1.5	-1.3	1.4	1.5
Run reversals in cocaine runway, males	0.7	0.7	0.8	-0.8	-0.9	0.7	-0.8	-0.9
Latency to leave start box in cocaine runway	0.4	0.4	0.5	-0.7	-0.7	0.6	-0.6	-0.7
Latency to leave start box in cocaine runway, F	1.6	1.7	1.9	-1.4	-1.4	1.2	-1.3	-1.4
Latency to leave start box in cocaine runway, M	0.5	0.5	0.6	0.7	0.8	-0.6	0.7	0.8
Std. dev. time between licks in bursts	3.2	3.8	4.6	1.9	1.9	-2.1	1.9	1.9
Total sessions with >9 infusions	0.1	0.1	0.1	0.3	0.3	-0.2	-0.1	0.3
Short access day 1 total inactive lever presses	3.4	3.8	4.1	2.0	2.0	-2.0	1.8	2.0
Short access day 10 total inactive lever presses	0.0	0.0	0.1	-0.1	-0.0	-0.1	0.2	-0.0
Short access day 1 total infusions	0.9	0.9	1.0	1.0	1.0	-1.0	0.9	1.0
Short access day 10 total infusions	0.1	0.1	0.1	0.3	0.3	-0.2	-0.0	0.3
Short access total infusions	0.5	0.6	0.6	0.8	0.8	-0.7	0.6	0.8
Short access day 1 locomotion	0.1	0.1	0.1	0.3	0.3	-0.2	0.1	0.3
Short access day 10 total locomotion	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.3	-0.1
Short access total locomotion	0.0	0.0	0.0	0.2	0.2	-0.1	-0.1	0.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	0.5	0.5	-0.3	0.1	0.5
Compulsive drug intake	0.0	0.0	0.0	0.0	-0.0	-0.1	0.2	-0.0
One hour access (shock baseline)	0.1	0.1	0.1	0.4	0.4	-0.2	-0.0	0.4
Social response proportion	0.4	0.4	0.6	-0.5	-0.6	0.7	-0.4	-0.8
Social responses	0.3	0.4	0.5	-0.6	-0.7	0.7	-0.5	-0.7
Social time	0.5	0.7	1.0	0.8	0.6	-0.8	1.0	0.8
Soleus weight	4.1	12.0	12.9	-3.6	-3.6	3.4	-3.3	-3.4
Bone: stiffness	0.1	0.2	0.3	-0.4	-0.4	0.5	-0.5	-0.5
Tibialis anterior weight	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.2	-0.2
Time to tail flick, vehicle, before self-admin	1.9	1.9	2.2	-1.5	-1.4	1.4	-1.3	-1.3
Time to tail flick, vehicle, after self-admin	0.6	0.6	0.9	-1.0	-0.8	0.7	-0.7	-0.8
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.4	-0.2	0.1	0.1	-0.1
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.5	0.5	-0.4	0.5	0.5
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	0.5	0.6	0.6	-0.7	0.7	0.5
Delta time to tail flick, test, before/after SA	0.4	0.4	0.6	0.8	0.6	-0.5	0.5	0.6
Tibia length	7.1	19.9	22.9	-4.7	-4.8	4.3	-4.2	-4.2
Ambulatory time before self-admin	0.0	0.0	0.1	0.2	0.1	-0.2	0.3	0.1
Ambulatory time after self-admin	0.0	0.0	0.0	0.0	-0.1	-0.1	0.1	-0.2
Bone: tissue strength	3.3	3.2	3.3	-1.8	-1.8	1.8	-1.8	-1.8
Total heroin consumption	1.3	1.5	1.8	-1.2	-1.1	1.2	-1.3	-1.2
Bone: trabecular number	0.5	0.8	0.9	0.9	0.9	-1.0	0.9	1.0
Bone: trabecular spacing	1.3	1.6	1.8	-1.2	-1.3	1.4	-1.2	-1.3
Bone: trabecular thickness	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.0	-0.0
Bone: trabecular tissue density	0.2	0.3	0.4	-0.6	-0.6	0.6	-0.5	-0.5
Water consumed over 24 hours	0.0	0.0	0.0	0.1	0.2	-0.1	0.1	0.1
Number of responses in last shaping day	0.7	0.8	0.8	0.9	0.9	-0.9	0.9	0.9