Hub : Genes

LOC108351548

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC108351548	0.03	0.02	1.2e-03	0.02	0.02	0.01	0.02	1.0e-03	2.4e-03	1.1e-02	4.4e-03
2	Adipose	intron excision ratio	chr7_128970385_128978815	0.05	0.04	2.8e-04	0.02	0.02	0.02	0.02	1.1e-03	1.1e-03	2.0e-03	1.4e-03
3	Adipose	mRNA stability	LOC108351548	0.05	0.04	3.1e-07	0.05	0.05	0.05	0.05	3.2e-06	3.2e-06	4.6e-06	4.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bone: apparent density	7.9	13.3	14.5	3.5	-3.8	-3.6
Area under the delay curve	1.8	1.9	2.3	1.3	-1.5	-1.3
BMI with tail	5.2	16.7	18.1	4.0	-4.3	-4.0
BMI without tail	0.1	0.2	0.2	0.4	-0.4	-0.4
Body weight	7.7	32.1	32.6	5.7	-5.7	-5.6
Weight adjusted by age	2.4	2.7	3.1	1.7	-1.4	-1.8
Bone surface	10.5	18.5	19.4	4.3	-4.4	-4.3
Bone volume	7.0	11.8	12.4	3.4	-3.5	-3.4
Breakpoint value in progressive ratio session	0.1	0.1	0.2	0.2	-0.4	-0.4
Number of licking bursts	0.3	0.4	0.7	-0.5	0.9	0.4
Context. condit. distance diff. score	0.4	0.5	0.5	0.7	-0.6	-0.7
Locomotion velocity, session 1	0.5	0.6	0.7	-0.7	0.8	0.7
Locomotion distance, session 1	2.6	3.3	4.0	-1.9	1.6	2.0
Locomotion velocity, session 2	0.2	0.2	0.3	-0.5	0.3	0.5
Locomotion distance, session 2	2.1	2.9	3.4	-1.7	1.5	1.9
Locomotion velocity, session 3	2.9	3.4	3.9	-1.8	1.7	2.0
Locomotion distance, session 3	5.0	5.5	5.8	-2.4	2.2	2.4
Stereotopy head waving bouts, day 3	0.7	0.9	1.1	1.0	-0.8	-1.0
Stereotopy head waving duration, day 3	0.2	0.3	0.4	0.5	-0.4	-0.6
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	0.2	0.1
Locomotion distance, session 7	1.2	1.5	1.6	-1.2	1.3	1.2
Stereotopy head waving bouts, day 7	0.9	1.1	1.3	1.1	-0.8	-1.1
Stereotopy head waving duration, day 7	1.6	1.9	2.2	1.4	-1.2	-1.5
Locomotion velocity, session 8	0.2	0.2	0.2	0.5	-0.5	-0.4
Locomotion distance, session 8	0.8	1.2	1.5	-1.1	0.9	1.2
Degree of sensitization distance	0.8	0.8	0.9	1.0	-0.8	-0.9
Degree of sensitization stereotypy	0.5	0.6	0.7	0.8	-0.6	-0.8
Conditioned locomotion	0.1	0.1	0.2	-0.1	0.4	-0.0
Cocaine response after cond. corrected	0.2	0.2	0.5	0.2	-0.7	-0.1
Cocaine response after cond. not corrected	0.7	0.7	1.0	-1.0	0.5	1.0
Cocaine response before conditioning	7.2	8.7	9.6	-3.0	3.1	2.8
Saline control response	0.1	0.2	0.3	-0.5	0.4	0.3
Bone: connectivity density	6.1	9.5	10.8	3.0	-3.3	-3.0
Bone: cortical apparent density	0.6	0.8	0.9	-0.9	0.9	0.7
Bone: cortical area	10.1	15.2	15.5	3.9	-3.9	-3.9
Bone: cortical porosity	2.4	2.6	3.1	-1.6	1.8	1.5
Bone: cortical porosity	2.9	3.1	3.7	-1.7	1.9	1.6
Bone: cortical thickness	4.2	6.9	7.1	2.6	-2.7	-2.6
Bone: cortical thickness	0.3	0.3	0.4	0.6	-0.6	-0.5
Bone: cortical tissue density	0.7	1.0	1.1	-1.0	1.1	0.9
Condit. Reinf. active minus inactive responses	0.1	0.1	0.1	-0.3	0.1	0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.3	-0.6	-0.3
Condit. Reinf. active responses	0.5	0.6	0.8	-0.8	0.6	0.9
Condit. Reinf. inactive responses	2.9	3.5	3.7	-1.8	1.9	1.8
Incentive salience index mean	0.0	0.0	0.1	0.1	-0.3	-0.1
Condit. Reinf. lever presses	0.2	0.3	0.3	0.4	-0.6	-0.5
Condit. Reinf. active minus inactive responses	0.0	0.0	0.0	-0.1	0.2	0.1
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.2	-0.5	0.4	0.5
Condit. Reinf. active responses	0.3	0.4	0.5	-0.7	0.6	0.5
Condit. Reinf. inactive responses	1.1	1.4	1.7	-1.2	1.3	1.0
Condit. Reinf. lever presses	0.0	0.0	0.1	-0.2	0.1	0.1
Condit. Reinf. lever reinforcers received	0.6	0.8	0.9	-1.0	0.9	0.8
Conditioned reinforcement - actives	1.6	1.6	1.7	-1.3	1.2	1.2
Conditioned reinforcement - inactives	1.1	1.2	1.4	-1.2	0.9	1.2
Conditioned locomotion	0.3	0.4	0.6	-0.6	0.7	0.5
Patch foraging indifference point 0 sec	1.4	2.3	2.5	-1.4	1.5	1.6
Patch foraging indifference point AUC	0.2	0.2	0.3	-0.5	0.5	0.3
Delay disc. indifference point, 0s delay	1.6	1.8	1.9	1.4	-1.2	-1.4
Delay disc. indifference point, 16s delay	1.8	1.8	1.8	1.3	-1.3	-1.3
Delay disc. indifference point, 2s delay	1.0	1.1	1.1	1.1	-1.0	-1.1
Delay disc. indifference point, 24s delay	1.6	1.5	1.6	1.3	-1.2	-1.3
Delay disc. indifference point, 4s delay	0.6	0.6	1.0	0.7	-1.0	-0.6
Delay disc. indifference point, 8s delay	4.2	4.3	5.2	2.0	-2.3	-2.0
Indifference point function ln k	3.6	5.0	5.5	2.4	-2.1	-2.2
Indifference point function log k	3.6	5.0	5.5	2.4	-2.1	-2.2
Patch foraging total patch changes 0 sec	1.4	2.3	2.4	-1.4	1.6	1.6
Patch foraging total patch changes 12 sec	1.5	1.9	2.0	-1.4	1.4	1.3
Patch foraging total patch changes 18 sec	3.6	4.7	5.2	-2.2	2.3	2.0
Patch foraging total patch changes 24 sec	1.4	1.7	2.2	-1.2	1.5	1.1
Patch foraging total patch changes 6 sec	2.6	3.8	4.2	-2.1	1.9	1.9
Patch foraging time to switch 0 sec	3.3	5.1	5.3	-2.3	2.3	2.2
Patch foraging water rate 0 sec	4.6	7.4	7.8	2.8	-2.7	-2.7
Patch foraging water rate 12 sec	3.7	5.6	6.0	2.4	-2.3	-2.4
Patch foraging water rate 18 sec	0.8	1.1	1.1	1.0	-1.1	-1.0
Patch foraging water rate 24 sec	3.2	4.5	4.9	2.2	-2.0	-2.2
Patch foraging water rate 6 sec	4.8	7.0	7.2	2.7	-2.6	-2.6
Seeking ratio, delayed vs. immediate footshock	0.4	0.5	0.8	0.6	-0.9	-0.5
Distance traveled before self-admin	1.2	1.2	1.6	-1.0	1.3	1.0
Distance traveled after self-admin	0.1	0.1	0.1	-0.3	0.1	0.3
Extensor digitorum longus weight	6.3	24.6	25.1	5.0	-4.9	-5.0
Bone: elastic displacement	5.1	5.8	5.9	-2.4	2.4	2.4
Bone: elastic work	0.1	0.1	0.2	-0.4	0.4	0.3
Bone: endosteal estimation	7.4	16.0	16.8	4.1	-3.8	-4.1
Bone: endosteal perimeter	6.9	14.2	14.9	3.9	-3.6	-3.8
Epididymis fat weight	0.6	1.5	2.0	1.1	-1.4	-1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.4	0.3	-0.6	-0.2
Delta time in open arm before/after self-admin	3.9	3.8	4.1	-2.0	2.0	1.9
Diff in mean of infusions in LGA sessions	1.1	1.2	1.4	1.0	-1.2	-1.1
Delay discount exponential model param	1.5	1.6	1.9	-1.2	1.4	1.1
Extinction: sum of active levers before priming	0.4	0.4	0.5	0.6	-0.6	-0.7
Active lever presses in extinction session 6	0.5	0.4	0.6	0.6	-0.8	-0.6
Bone: final force	10.3	16.7	17.3	4.1	-4.2	-4.0
Bone: final moment	10.4	16.9	17.8	4.1	-4.2	-4.0
Food consumed during 24 hour testing period	1.4	1.7	2.3	1.2	-1.5	-1.1
Glucose	0.1	0.1	0.2	0.3	-0.2	-0.4
Heart weight	0.0	0.0	0.1	0.0	-0.3	-0.0
Delay discount hyperbolic model param	1.4	1.5	1.8	-1.2	1.3	1.1
Intermittent access intake day 1-15 change	0.9	0.9	1.1	-1.0	0.7	1.0
Intermittent access intake escalation	0.5	0.5	0.7	-0.8	0.5	0.8
Intermittent access intake escalation 2	0.9	0.8	1.1	-1.1	0.7	1.0
Intermitt. access day 1 inactive lever presses	3.7	4.0	5.1	-1.9	2.2	1.8
Intermitt. access day 15 inactive lever presses	1.0	1.1	1.2	-1.0	1.1	1.0
Intermitt. access escalation Index	0.4	0.4	0.5	-0.6	0.7	0.5
Intermittent access day 1 total infusions	1.3	1.5	1.6	-1.2	1.2	1.3
Intermittent access day 15 total infusions	2.3	2.6	2.8	-1.7	1.5	1.6
Intermittent access terminal intake (last 3 days)	2.4	2.6	2.8	-1.7	1.5	1.7
Intermittent access total infusions	2.4	2.6	2.8	-1.7	1.6	1.6
Intermittent access day 1 locomotion	1.1	1.2	1.7	-1.0	1.3	0.9
Intermittent access day 15 total locomotion	1.1	1.1	1.7	-1.0	1.3	0.9
Intermittent access total locomotion	2.8	3.2	4.1	-1.7	2.0	1.6
Intermittent access standard deviation	0.5	0.6	0.7	-0.7	0.7	0.8
Left kidney weight	0.6	1.6	2.7	1.0	-1.6	-1.0
Right kidney weight	3.1	8.6	8.7	3.0	-2.9	-2.9
Cocaine induced anxiety	1.0	1.1	1.4	1.0	-1.0	-1.2
Post-drug Anxiety	4.1	4.5	4.9	2.1	-2.1	-2.2
Baseline Anxiety	1.2	1.3	1.5	1.2	-1.1	-1.1
Tail length	0.0	0.1	0.2	-0.3	0.4	0.3
Length with tail	2.2	8.2	8.4	2.9	-2.8	-2.9
Length without tail	8.5	18.6	19.9	4.3	-4.5	-4.2
Times rat made contact with spout	0.1	0.2	0.3	0.3	-0.6	-0.2
Lifetime Intake	1.8	2.0	2.2	-1.5	1.3	1.4
Liver weight, left	1.9	3.0	3.1	1.7	-1.7	-1.8
Liver weight, right	1.9	3.2	3.3	1.8	-1.8	-1.8
Locomotor activity	0.9	1.5	1.8	-1.2	1.3	1.1
Locomotor testing distance	2.7	4.5	5.1	-2.0	2.3	2.1
Locomotor testing rearing	2.8	4.3	5.2	-2.0	2.3	1.9
Locomotion in novel chamber	0.8	1.0	1.1	1.0	-0.9	-1.0
Locomotion in novel chamber post-restriction	0.6	0.7	0.7	0.9	-0.8	-0.8
Fecal boli incidents, locomotor time 1	0.6	0.6	1.1	-0.9	0.2	1.0
Change in fecal boli incidents, locomotor task	0.7	0.7	0.8	0.9	-0.7	-0.9
Time >=10cm from walls, locomotor time 1	0.8	0.8	1.1	0.8	-1.1	-0.8
Bouts of movement, locomotor time 1	0.3	0.3	0.4	0.5	-0.6	-0.4
Total resting periods, locomotor time 1	0.0	0.0	0.0	-0.1	-0.1	0.1
Rest time, locomotor task time 1	0.0	0.0	0.1	-0.2	0.1	0.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	0.5	0.3
Vertical activity count, locomotor time 1	1.3	1.3	1.7	1.1	-1.3	-1.0
Time >=10cm from walls, locomotor time 2	0.2	0.2	0.3	-0.5	0.4	0.5
Bouts of movement, locomotor time 2	3.2	3.5	3.8	1.9	-1.7	-2.0
Total resting periods, locomotor time 2	3.4	3.6	4.1	2.0	-1.7	-2.0
Rest time, locomotor task time 2	0.2	0.2	0.3	0.5	-0.5	-0.4
Distance moved, locomotor task time 2	0.4	0.4	0.5	-0.7	0.7	0.6
Vertical activity count, locomotor time 2	0.2	0.2	0.2	0.5	-0.4	-0.4
Light reinforcement 1	3.2	5.8	7.2	-2.4	2.7	2.2
Light reinforcement 2	0.9	1.2	1.4	-1.2	1.1	1.0
Bone: marrow area	7.4	16.1	17.0	4.1	-3.8	-4.1
Bone: maximum diameter	4.8	8.9	9.6	3.1	-2.8	-3.0
Bone: maximum force	12.8	22.1	22.2	4.7	-4.7	-4.7
Bone: maximum moment	12.8	22.1	22.1	4.7	-4.7	-4.7
Mean time between licks in bursts	0.5	0.7	0.7	-0.9	0.8	0.8
Mean num. licks in bursts	0.2	0.2	0.6	0.2	-0.8	0.0
Cd content in liver	0.2	0.3	0.3	-0.5	0.5	0.5
Co content in liver	0.2	0.2	0.3	-0.5	0.5	0.4
Cu content in liver	1.5	1.8	1.9	1.3	-1.4	-1.3
Fe content in liver	0.1	0.1	0.1	-0.4	0.3	0.3
K content in liver	1.6	1.6	2.0	1.2	-1.4	-1.1
Mg content in liver	0.0	0.0	0.1	0.2	-0.3	-0.1
Mn content in liver	0.2	0.2	0.3	0.5	-0.3	-0.4
Na content in liver	0.2	0.2	0.3	0.5	-0.4	-0.4
Rb content in liver	0.0	0.0	0.0	-0.1	0.2	0.1
Se content in liver	0.3	0.3	0.4	-0.6	0.4	0.6
Sr content in liver	0.9	0.8	0.9	0.9	-0.9	-0.9
Zn content in liver	0.4	0.5	0.6	-0.6	0.8	0.7
Bone: minimum diameter	7.7	14.4	15.4	3.9	-3.6	-3.9
Time in familiar zone, hab. session 1	0.1	0.1	0.2	-0.4	0.2	0.5
Time in novel zone, hab. session 1	0.1	0.1	0.2	0.2	0.1	-0.4
Total zone transitions, hab. session 1	0.3	0.4	0.4	-0.6	0.7	0.6
Total locomotion distance, hab. session 1	0.0	0.0	0.1	-0.3	0.1	0.2
Locomotion velocity, hab. session 1	0.0	0.0	0.0	-0.2	0.0	0.1
Time in familiar zone, hab. session 2	0.1	0.1	0.1	0.1	-0.4	-0.2
Time in novel zone, hab. session 2	0.1	0.1	0.3	-0.1	0.5	0.1
Total zone transitions, hab. session 2	0.0	0.1	0.1	-0.2	0.0	0.4
Total locomotion distance, hab. session 2	0.1	0.1	0.2	-0.4	0.2	0.5
Locomotion velocity, hab. session 2	0.0	0.0	0.1	-0.2	-0.1	0.2
Novel to familiar place preference ratio	0.9	1.0	1.3	1.0	-0.7	-1.2
Novelty place preference	0.5	0.5	0.8	0.7	-0.4	-0.9
Time in novel zone, NPP test	0.3	0.3	0.6	0.6	-0.2	-0.8
Total zone transitions, NPP test	0.8	1.2	1.5	-1.2	0.9	1.2
Total locomotion distance, NPP test	2.3	3.2	3.5	-1.9	1.6	1.8
Locomotion velocity, NPP test	1.2	1.7	1.9	-1.4	1.1	1.4
Intraocular pressure	11.1	15.5	16.1	-4.0	4.0	3.8
Delta distance traveled before/after self-admin	0.2	0.3	0.5	0.4	-0.7	-0.3
Delta ambulatory time before/after self-admin	0.1	0.1	0.3	0.2	-0.5	-0.2
Parametrial fat weight	0.9	1.8	2.2	-1.4	1.1	1.5
Pavlov. Cond. lever latency	0.0	0.0	0.1	0.2	-0.1	-0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.0	-0.1	-0.1	0.2
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	-0.0	-0.1	-0.1
Pavlov. Cond. index score	0.1	0.1	0.1	0.2	-0.4	-0.3
Pavlov. Cond. latency score	0.0	0.0	0.1	0.1	-0.3	-0.2
Pavlov. Cond. lever contacts	0.3	0.4	0.5	-0.7	0.5	0.6
Pavlov. Cond. magazine entry number	0.0	0.0	0.0	0.1	0.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.6	-0.7	0.6	0.8
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	0.6	0.6	-0.8	-0.7
Pavlov. Cond. response bias	0.1	0.1	0.1	-0.3	0.1	0.3
Pavlov. Cond. lever latency	0.1	0.1	0.2	0.4	-0.2	-0.2
Pavlov. Cond. magazine entry latency	0.2	0.3	0.4	0.5	-0.5	-0.6
Pavlov. Cond. change in total contacts	0.7	1.0	1.3	0.8	-1.1	-1.1
Pavlov. Cond. index score	0.1	0.1	0.2	0.2	-0.4	-0.5
Pavlov. Cond. latency score	0.2	0.2	0.3	0.3	-0.5	-0.5
Pavlov. Cond. lever contacts	0.3	0.4	0.6	-0.8	0.5	0.5
Pavlov. Cond. magazine entry number	1.1	1.3	1.7	-1.1	1.1	1.3
Pavlov. Cond. intertrial magazine entries	2.4	3.1	3.8	-1.7	1.6	2.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.3	0.5	0.4	-0.6	-0.7
Pavlov. Cond. response bias	0.2	0.2	0.4	-0.6	0.4	0.3
Time in closed arm before self-admin	0.9	1.0	1.3	1.1	-0.7	-1.1
Time in closed arm after self-admin	0.3	0.3	0.4	0.6	-0.5	-0.6
Time in open arm before self-admin	1.0	1.1	1.2	1.1	-1.0	-1.1
Time in open arm after self-admin	0.2	0.3	0.4	-0.5	0.6	0.5
Bone: periosteal estimation	11.9	24.6	25.3	5.0	-4.8	-5.0
Bone: periosteal perimeter	11.2	18.6	18.8	4.3	-4.3	-4.3
Bone: post-yield work	8.2	11.1	12.0	3.5	-3.1	-3.4
Progressive ratio test 1 active lever presses	3.6	3.8	4.0	-2.0	2.0	1.9
Progressive ratio test 1 breakpoint	3.3	3.4	3.6	-1.9	1.9	1.8
Progressive ratio test 1 inactive lever presses	2.4	2.6	2.8	-1.6	1.7	1.6
Progressive ratio test 2 active lever presses	1.8	1.9	2.2	-1.4	1.5	1.3
Progressive ratio test 2 breakpoint	2.4	2.7	3.1	-1.7	1.8	1.5
Progressive ratio test 2 inactive lever presses	2.9	3.3	3.7	-1.8	1.9	1.8
Incentive Sensitization - Responses	0.1	0.1	0.1	0.3	-0.1	-0.3
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	0.0	-0.1
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.3	-0.5	0.4	0.4
Progressive ratio	0.0	0.0	0.0	-0.1	-0.2	0.0
Food seeking constrained by brief footshock	0.0	0.0	0.0	-0.0	-0.2	-0.0
Seeking ratio, punishment vs. effort	0.0	0.0	0.0	0.1	0.0	-0.1
Retroperitoneal fat weight	0.0	0.1	0.3	-0.4	-0.1	0.5
Reaction time number correct	0.5	0.7	0.7	0.8	-0.8	-0.9
Reaction time mean minus median	8.8	11.6	12.7	-3.5	3.1	3.6
Reaction time mean minus median AUC	6.6	8.5	9.3	-3.0	2.7	3.0
Reaction time num false alarms	1.7	2.4	2.7	-1.4	1.5	1.7
Reaction time num false alarms AUC	2.9	4.0	4.7	-1.9	1.9	2.2
Reaction time trials correct on left	0.5	0.7	0.7	0.8	-0.8	-0.9
Reaction time trials on left	0.3	0.4	0.5	0.6	-0.6	-0.7
Reaction time mean	0.7	1.0	1.3	-1.2	0.8	1.0
Reaction time mean AUC	0.4	0.6	0.8	-0.9	0.5	0.8
Median of all reaction times	0.0	0.0	0.0	-0.2	-0.1	-0.0
Reaction time omissions	9.9	13.5	14.5	-3.8	3.5	3.7
Reaction time false alarm rate	2.2	3.0	3.6	-1.7	1.7	1.9
Reaction time premature initiation rate	4.4	5.9	6.6	-2.6	2.4	2.3
Reaction time premature initiations	2.7	3.7	4.2	-2.0	1.9	1.8
Std. dev. reaction times	6.5	9.2	10.1	-3.2	2.8	3.1
Reaction time trials completed	0.3	0.4	0.5	0.6	-0.6	-0.7
Reaction time trials AUC	0.7	1.0	1.1	1.0	-1.0	-1.1
Run reversals in cocaine runway, females	0.3	0.3	0.5	-0.5	0.7	0.5
Run reversals in cocaine runway, males	1.3	1.3	1.5	-1.2	1.1	1.1
Latency to leave start box in cocaine runway	0.0	0.0	0.0	-0.1	0.1	0.1
Latency to leave start box in cocaine runway, F	2.0	2.2	2.6	-1.5	1.6	1.4
Latency to leave start box in cocaine runway, M	2.7	2.6	2.9	1.7	-1.7	-1.5
Std. dev. time between licks in bursts	1.2	1.4	1.6	-1.2	1.3	1.1
Total sessions with >9 infusions	0.3	0.4	0.4	-0.6	0.6	0.6
Short access day 1 total inactive lever presses	0.8	0.9	1.1	-1.1	0.9	0.9
Short access day 10 total inactive lever presses	0.5	0.5	0.7	-0.7	0.9	0.5
Short access day 1 total infusions	0.0	0.0	0.1	0.2	-0.3	-0.2
Short access day 10 total infusions	0.5	0.5	0.6	-0.8	0.6	0.8
Short access total infusions	0.1	0.1	0.2	-0.4	0.3	0.4
Short access day 1 locomotion	0.0	0.0	0.0	0.2	0.1	-0.1
Short access day 10 total locomotion	0.2	0.2	0.6	-0.3	0.8	0.2
Short access total locomotion	0.2	0.2	0.4	-0.3	0.7	0.3
One hour access (0.3 mA shock)	0.2	0.2	0.2	-0.5	0.3	0.4
Compulsive drug intake	0.6	0.6	0.7	0.8	-0.9	-0.7
One hour access (shock baseline)	0.0	0.0	0.0	-0.1	0.1	0.1
Social response proportion	0.6	0.7	0.9	-1.0	0.7	0.7
Social responses	9.1	11.7	12.2	-3.4	3.5	3.3
Social time	0.6	0.8	1.0	-1.0	0.8	0.9
Soleus weight	1.1	3.1	3.5	1.9	-1.7	-1.8
Bone: stiffness	15.8	24.9	25.4	5.0	-4.9	-5.0
Tibialis anterior weight	2.5	8.6	9.4	3.1	-2.7	-3.0
Time to tail flick, vehicle, before self-admin	1.3	1.3	1.5	-1.2	1.0	1.2
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.1	0.2	0.3	-0.2
Time to tail flick, test, before self-admin	0.7	0.7	0.7	-0.8	0.8	0.8
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.3	-0.3	-0.3
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.4	0.7	-0.3	-0.6
Delta time to tail flick, test, before/after SA	0.4	0.4	0.4	0.7	-0.6	-0.6
Tibia length	5.9	16.7	18.1	4.0	-3.9	-4.3
Ambulatory time before self-admin	4.1	4.2	4.9	-2.0	2.2	1.9
Ambulatory time after self-admin	1.4	1.5	1.6	-1.3	1.3	1.2
Bone: tissue strength	0.3	0.3	0.4	0.4	-0.5	-0.6
Total heroin consumption	2.3	2.6	3.3	1.6	-1.4	-1.8
Bone: trabecular number	4.5	7.1	8.8	2.5	-3.0	-2.5
Bone: trabecular spacing	1.3	1.7	2.5	-1.2	1.6	1.2
Bone: trabecular thickness	0.3	0.3	0.4	-0.6	0.4	0.6
Bone: trabecular tissue density	0.1	0.2	0.3	-0.5	0.6	0.3
Water consumed over 24 hours	0.2	0.2	0.3	0.4	-0.6	-0.3
Number of responses in last shaping day	0.4	0.4	0.5	0.6	-0.5	-0.7