LOC108351548

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	gene expression	LOC108351548	0.02	0.02	4.2e-03	0.02	0.02	0.01	0.02	4.1e-03	4.2e-03	1.3e-02	4.3e-03
2	Adipose	isoform ratio	XR_010053083.1	0.04	0.04	1.8e-04	0.03	0.02	0.02	0.02	5.7e-04	1.0e-03	1.0e-03	1.4e-03
3	Adipose	mRNA stability	LOC108351548	0.07	0.05	1.6e-07	0.05	0.06	0.05	0.05	6.2e-06	7.8e-07	4.2e-06	2.0e-06
4	Adipose	alternative TSS	XR_010053082.1	0.05	0.05	1.2e-04	0.03	0.02	0.01	0.02	5.1e-04	1.4e-03	7.4e-03	1.9e-03
5	Adipose	alternative TSS	XR_010053083.1	0.04	0.04	2.4e-04	0.02	0.02	0.01	0.02	9.7e-04	2.5e-03	1.2e-02	3.4e-03
6	Adipose	intron excision ratio	chr7_130849476_130857905	0.05	0.04	1.4e-04	0.03	0.03	0.03	0.03	6.1e-04	3.8e-04	1.2e-04	8.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	7.3	12.6	16.2	4.0	-3.5	-3.4	3.4	-3.4	-3.5
Area under the delay curve	1.4	1.6	2.3	1.3	-1.2	-1.1	1.2	-1.2	-1.5
BMI with tail	6.6	22.6	25.6	5.1	-4.9	-4.7	4.9	-4.9	-4.1
BMI without tail	2.2	6.7	7.8	2.6	-2.7	-2.6	2.8	-2.8	-2.0
Body weight	6.7	29.1	33.3	5.8	-5.7	-5.5	5.4	-5.4	-4.4
Weight adjusted by age	1.8	2.8	5.2	2.3	-1.9	-2.2	1.2	-1.2	0.5
Bone surface	9.7	17.7	20.7	4.5	-4.1	-4.1	4.2	-4.2	-4.1
Bone volume	6.5	11.7	15.7	4.0	-3.4	-3.4	3.3	-3.3	-3.2
Breakpoint value in progressive ratio session	1.3	1.5	2.3	0.9	-1.0	-1.1	1.4	-1.4	-1.5
Number of licking bursts	0.4	0.6	2.4	-0.2	0.4	0.1	-0.7	0.7	1.5
Context. condit. distance diff. score	0.4	0.5	0.6	0.7	-0.7	-0.8	0.7	-0.7	-0.7
Locomotion velocity, session 1	0.6	0.7	1.2	-1.1	0.7	0.6	-0.9	0.9	0.6
Locomotion distance, session 1	2.5	3.1	4.3	-1.9	1.9	2.1	-1.9	1.9	0.1
Locomotion velocity, session 2	0.3	0.3	0.6	-0.8	0.5	0.6	-0.5	0.5	-0.6
Locomotion distance, session 2	1.8	2.6	3.9	-1.9	1.8	2.0	-1.5	1.5	-0.2
Locomotion velocity, session 3	3.0	3.4	4.2	-2.0	1.9	2.0	-1.9	1.9	1.2
Locomotion distance, session 3	4.2	4.6	5.9	-2.3	2.4	2.4	-2.1	2.1	1.2
Stereotopy head waving bouts, day 3	0.7	0.8	1.2	1.0	-1.0	-1.1	0.9	-0.9	-0.0
Stereotopy head waving duration, day 3	0.2	0.3	0.5	0.5	-0.6	-0.7	0.6	-0.6	0.0
Locomotion velocity, session 7	0.0	0.0	0.0	-0.1	0.2	0.1	-0.1	0.1	-0.2
Locomotion distance, session 7	1.1	1.4	1.9	-1.0	1.2	1.1	-1.4	1.4	0.9
Stereotopy head waving bouts, day 7	1.4	1.6	2.3	1.1	-1.3	-1.5	1.5	-1.5	-0.2
Stereotopy head waving duration, day 7	1.6	1.9	2.9	1.0	-1.4	-1.5	1.7	-1.7	-0.6
Locomotion velocity, session 8	0.5	0.7	2.8	0.0	-0.5	-0.3	0.6	-0.6	-1.7
Locomotion distance, session 8	0.8	1.2	1.9	-1.3	1.2	1.4	-0.8	0.8	-0.7
Degree of sensitization distance	0.5	0.6	1.0	0.9	-0.9	-1.0	0.6	-0.6	-0.3
Degree of sensitization stereotypy	0.6	0.7	1.2	0.4	-0.8	-0.9	1.1	-1.1	-0.1
Conditioned locomotion	0.1	0.1	0.2	0.1	0.1	-0.3	-0.3	0.3	0.4
Cocaine response after cond. corrected	0.2	0.2	1.3	-0.1	-0.3	0.2	0.0	-0.0	-1.2
Cocaine response after cond. not corrected	0.8	0.9	1.5	-1.0	0.9	1.2	-1.1	1.1	0.1
Cocaine response before conditioning	6.1	7.3	9.2	-2.5	3.0	2.6	-2.5	2.5	3.0
Saline control response	0.1	0.1	0.3	-0.2	0.5	0.4	-0.3	0.3	-0.2
Bone: connectivity density	5.4	8.5	10.4	3.1	-2.9	-2.7	2.8	-2.8	-3.2
Bone: cortical apparent density	0.4	0.5	1.2	-0.7	0.7	0.6	-0.5	0.5	1.1
Bone: cortical area	9.7	14.9	18.1	4.3	-4.0	-4.1	3.8	-3.8	-2.9
Bone: cortical porosity	2.2	2.4	3.2	-1.3	1.6	1.4	-1.5	1.5	1.8
Bone: cortical porosity	2.1	2.3	3.2	-1.5	1.7	1.4	-1.3	1.3	1.8
Bone: cortical thickness	4.3	7.1	8.7	2.9	-2.7	-2.8	2.7	-2.7	-2.1
Bone: cortical thickness	0.2	0.2	0.5	0.7	-0.7	-0.6	0.3	-0.3	-0.2
Bone: cortical tissue density	0.5	0.6	1.4	-0.8	0.8	0.6	-0.6	0.6	1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.3	0.3	0.5	-0.1	0.1	-0.5
Condit. Reinf. active-inactive response ratio	0.2	0.3	1.0	0.2	-0.3	-0.1	0.4	-0.4	-1.0
Condit. Reinf. active responses	0.5	0.6	1.0	-0.7	0.8	1.0	-0.8	0.8	-0.3
Condit. Reinf. inactive responses	2.6	3.2	4.2	-1.6	1.8	1.8	-2.1	2.1	1.4
Incentive salience index mean	0.2	0.2	0.9	0.3	-0.1	-0.1	0.3	-0.3	-0.9
Condit. Reinf. lever presses	0.4	0.6	1.5	0.8	-0.5	-0.5	0.7	-0.7	-1.2
Condit. Reinf. active minus inactive responses	0.1	0.1	0.2	-0.2	0.1	0.1	-0.4	0.4	0.5
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.2	-0.6	0.5	0.5	-1.1	1.1	0.9
Condit. Reinf. active responses	0.3	0.4	0.5	-0.6	0.6	0.5	-0.7	0.7	0.5
Condit. Reinf. inactive responses	0.6	0.8	1.0	-0.9	1.0	0.9	-0.9	0.9	0.9
Condit. Reinf. lever presses	0.0	0.0	0.1	0.0	0.0	0.0	0.1	-0.1	-0.3
Condit. Reinf. lever reinforcers received	0.5	0.7	0.9	-0.9	0.8	0.8	-1.0	1.0	0.7
Conditioned reinforcement - actives	0.3	0.5	1.0	-1.0	0.8	0.8	-0.3	0.3	0.8
Conditioned reinforcement - inactives	2.6	3.8	4.2	-2.0	1.8	1.9	-2.0	2.0	2.0
Conditioned locomotion	0.1	0.2	0.2	-0.5	0.4	0.1	0.5	-0.5	0.4
Patch foraging indifference point 0 sec	1.1	2.0	2.8	-1.4	1.3	1.7	-1.5	1.5	0.9
Patch foraging indifference point AUC	0.5	0.8	1.0	-1.0	0.9	0.9	-0.8	0.8	0.9
Delay disc. indifference point, 0s delay	1.4	1.6	2.0	1.2	-1.3	-1.4	1.3	-1.3	-1.0
Delay disc. indifference point, 16s delay	1.5	1.7	2.0	1.4	-1.2	-1.2	1.3	-1.3	-1.2
Delay disc. indifference point, 2s delay	0.8	0.9	1.1	0.9	-1.0	-1.0	1.0	-1.0	-0.7
Delay disc. indifference point, 24s delay	1.1	1.3	1.8	1.3	-1.2	-1.1	1.1	-1.1	-0.8
Delay disc. indifference point, 4s delay	0.7	0.8	2.0	0.8	-0.8	-0.5	0.7	-0.7	-1.4
Delay disc. indifference point, 8s delay	3.3	3.9	5.6	1.9	-1.8	-1.7	2.0	-2.0	-2.4
Indifference point function ln k	2.6	4.5	5.4	2.3	-2.3	-2.3	2.0	-2.0	-1.9
Indifference point function log k	2.6	4.5	5.4	2.3	-2.3	-2.3	2.0	-2.0	-1.9
Patch foraging total patch changes 0 sec	1.0	1.9	2.7	-1.4	1.4	1.6	-1.5	1.5	0.8
Patch foraging total patch changes 12 sec	1.3	1.6	2.3	-1.5	1.3	1.4	-1.2	1.2	1.0
Patch foraging total patch changes 18 sec	2.7	4.1	4.7	-2.0	2.0	2.0	-2.2	2.2	1.9
Patch foraging total patch changes 24 sec	1.0	1.7	2.6	-1.1	1.2	1.1	-1.3	1.3	1.6
Patch foraging total patch changes 6 sec	2.4	3.6	4.4	-1.8	1.9	2.0	-2.1	2.1	1.4
Patch foraging time to switch 0 sec	2.2	4.4	5.5	-2.3	2.1	2.1	-2.0	2.0	2.0
Patch foraging water rate 0 sec	3.9	8.1	8.9	2.8	-2.7	-2.8	3.0	-3.0	-2.9
Patch foraging water rate 12 sec	2.6	5.3	6.1	2.3	-2.3	-2.4	2.5	-2.5	-1.8
Patch foraging water rate 18 sec	0.7	1.1	1.4	0.9	-1.1	-1.0	1.2	-1.2	-0.6
Patch foraging water rate 24 sec	3.9	5.4	8.1	2.0	-2.0	-2.3	2.8	-2.8	-1.8
Patch foraging water rate 6 sec	5.1	7.4	8.9	2.6	-2.7	-2.8	3.0	-3.0	-2.1
Seeking ratio, delayed vs. immediate footshock	0.3	0.3	1.6	0.1	-0.3	-0.1	0.4	-0.4	-1.3
Distance traveled before self-admin	0.3	0.4	0.7	-0.7	0.7	0.6	-0.5	0.5	0.8
Distance traveled after self-admin	0.3	0.3	0.7	-0.4	0.5	0.5	0.5	-0.5	-0.9
Extensor digitorum longus weight	5.5	21.4	26.8	4.6	-5.2	-4.9	4.7	-4.7	-3.5
Bone: elastic displacement	4.4	5.1	6.0	-2.5	2.5	2.3	-2.2	2.2	1.8
Bone: elastic work	0.1	0.1	0.5	-0.2	0.3	0.2	-0.3	0.3	0.7
Bone: endosteal estimation	6.9	15.2	16.9	4.0	-4.1	-4.1	4.0	-4.0	-3.0
Bone: endosteal perimeter	6.4	13.6	15.2	3.9	-3.9	-3.9	3.8	-3.8	-2.7
Epididymis fat weight	1.8	6.2	8.2	1.9	-2.3	-2.0	2.8	-2.8	-2.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.3	0.4	0.5	-0.0	0.0	-0.5
Delta time in open arm before/after self-admin	1.0	1.0	1.6	-0.8	0.6	0.7	-1.1	1.1	1.3
Diff in mean of infusions in LGA sessions	0.6	0.7	1.2	0.8	-0.9	-0.8	0.6	-0.6	-1.1
Delay discount exponential model param	1.3	1.4	2.2	-1.2	1.1	1.0	-1.1	1.1	1.5
Extinction: sum of active levers before priming	1.1	1.3	1.9	1.1	-1.4	-1.4	1.1	-1.1	-0.4
Active lever presses in extinction session 6	1.1	1.1	1.4	1.2	-1.1	-1.0	1.1	-1.1	-1.0
Bone: final force	9.7	15.5	17.1	4.1	-4.0	-4.0	3.8	-3.8	-3.9
Bone: final moment	10.1	16.3	17.8	4.2	-4.1	-4.0	3.9	-3.9	-4.1
Food consumed during 24 hour testing period	1.1	1.6	2.9	1.2	-1.2	-1.0	1.1	-1.1	-1.7
Glucose	0.2	0.4	0.7	0.7	-0.5	-0.7	0.3	-0.3	0.9
Heart weight	0.2	0.3	0.5	0.3	-0.6	-0.4	0.6	-0.6	-0.7
Delay discount hyperbolic model param	1.1	1.2	2.0	-1.1	1.1	0.9	-1.0	1.0	1.4
Intermittent access intake day 1-15 change	0.0	0.0	0.1	-0.1	-0.0	0.2	-0.2	0.2	-0.3
Intermittent access intake escalation	0.0	0.1	0.1	0.2	-0.4	-0.1	0.0	-0.0	-0.3
Intermittent access intake escalation 2	0.0	0.0	0.0	-0.2	-0.2	0.2	-0.2	0.2	-0.2
Intermitt. access day 1 inactive lever presses	0.8	2.9	7.6	-1.4	1.4	1.0	-1.6	1.6	2.8
Intermitt. access day 15 inactive lever presses	0.7	1.5	1.9	-1.1	1.0	1.1	-1.3	1.3	1.4
Intermitt. access escalation Index	0.2	0.3	0.9	0.9	-0.6	-0.8	0.3	-0.3	0.1
Intermittent access day 1 total infusions	0.9	1.5	2.6	-1.0	1.1	1.1	-1.2	1.2	1.6
Intermittent access day 15 total infusions	0.6	0.9	2.2	-0.6	0.5	0.7	-1.1	1.1	1.5
Intermittent access terminal intake (last 3 days)	1.0	1.4	2.4	-1.0	0.9	1.0	-1.2	1.2	1.5
Intermittent access total infusions	1.2	1.4	2.5	-1.0	1.0	1.1	-1.2	1.2	1.6
Intermittent access day 1 locomotion	0.3	0.4	2.4	-0.1	0.2	-0.0	-0.2	0.2	1.6
Intermittent access day 15 total locomotion	0.3	0.6	3.1	-0.2	-0.0	-0.1	-0.4	0.4	1.8
Intermittent access total locomotion	0.8	1.0	4.2	-0.7	0.5	0.5	-0.6	0.6	2.0
Intermittent access standard deviation	0.2	0.4	0.5	-0.6	0.4	0.6	-0.7	0.7	0.7
Left kidney weight	1.2	5.6	10.6	2.4	-2.3	-1.9	2.0	-2.0	-3.3
Right kidney weight	4.2	18.9	23.5	4.8	-4.9	-4.6	4.0	-4.0	-3.7
Cocaine induced anxiety	3.4	4.8	6.2	2.0	-2.1	-2.1	2.5	-2.5	-1.9
Post-drug Anxiety	5.0	5.3	7.0	1.9	-2.0	-1.9	2.6	-2.6	-2.6
Baseline Anxiety	0.1	0.2	0.7	0.4	-0.3	-0.2	0.2	-0.2	-0.8
Tail length	0.0	0.2	0.2	0.4	-0.4	-0.4	0.4	-0.4	-0.4
Length with tail	1.6	7.1	8.4	2.8	-2.9	-2.8	2.6	-2.6	-2.2
Length without tail	6.2	19.9	22.4	4.5	-4.7	-4.3	4.4	-4.4	-4.4
Times rat made contact with spout	0.2	0.2	1.1	0.1	-0.4	-0.1	0.3	-0.3	-1.1
Lifetime Intake	1.2	1.5	2.6	-1.1	1.1	1.1	-1.1	1.1	1.6
Liver weight, left	7.9	13.1	16.5	4.1	-3.5	-3.7	3.5	-3.5	-3.3
Liver weight, right	2.4	4.1	5.3	2.3	-2.3	-2.2	1.9	-1.9	-1.5
Locomotor activity	0.9	1.5	1.9	-1.1	1.2	1.1	-1.2	1.2	1.4
Locomotor testing distance	2.3	4.1	5.3	-1.8	2.0	1.9	-2.1	2.1	2.3
Locomotor testing rearing	2.5	5.0	9.3	-1.7	1.9	1.8	-2.3	2.3	3.1
Locomotion in novel chamber	1.5	1.9	2.5	1.6	-1.5	-1.5	1.4	-1.4	-0.8
Locomotion in novel chamber post-restriction	0.2	0.4	0.7	0.2	-0.3	-0.4	0.9	-0.9	-0.6
Fecal boli incidents, locomotor time 1	0.5	0.8	1.6	-1.1	0.9	1.3	-0.1	0.1	-1.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.6	0.7	-0.7	-0.7	-0.2	0.2	0.3
Time >=10cm from walls, locomotor time 1	0.8	0.8	2.1	0.5	-0.7	-0.5	1.0	-1.0	-1.4
Bouts of movement, locomotor time 1	0.2	0.2	0.5	0.2	-0.4	-0.3	0.4	-0.4	-0.7
Total resting periods, locomotor time 1	0.1	0.1	0.2	-0.4	0.2	0.3	-0.1	0.1	-0.5
Rest time, locomotor task time 1	0.1	0.2	0.3	-0.5	0.2	0.4	-0.4	0.4	-0.3
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.4	0.4	0.2	0.0	-0.0	0.4
Vertical activity count, locomotor time 1	0.6	1.5	2.1	1.3	-1.2	-1.0	1.2	-1.2	-1.4
Time >=10cm from walls, locomotor time 2	0.2	0.3	0.4	-0.7	0.6	0.6	-0.6	0.6	0.2
Bouts of movement, locomotor time 2	2.3	3.7	4.6	2.0	-2.0	-2.1	1.9	-1.9	-1.4
Total resting periods, locomotor time 2	2.2	3.8	4.9	2.1	-2.1	-2.2	1.9	-1.9	-1.3
Rest time, locomotor task time 2	0.1	0.1	0.2	0.4	-0.4	-0.3	0.1	-0.1	-0.4
Distance moved, locomotor task time 2	0.4	0.4	0.6	-0.8	0.7	0.6	-0.6	0.6	0.8
Vertical activity count, locomotor time 2	0.2	0.2	0.3	0.5	-0.6	-0.5	0.5	-0.5	-0.4
Light reinforcement 1	1.8	4.5	6.7	-2.1	2.2	2.0	-1.9	1.9	2.6
Light reinforcement 2	0.7	1.1	1.5	-1.0	1.0	1.0	-1.2	1.2	0.9
Bone: marrow area	6.9	15.2	16.9	3.9	-4.1	-4.1	4.1	-4.1	-3.0
Bone: maximum diameter	4.2	7.8	9.8	3.0	-3.1	-3.1	2.8	-2.8	-1.6
Bone: maximum force	11.9	21.2	25.7	5.1	-4.8	-4.9	4.5	-4.5	-3.7
Bone: maximum moment	12.3	21.6	25.9	5.1	-4.8	-4.9	4.5	-4.5	-3.9
Mean time between licks in bursts	0.2	0.6	1.2	-0.8	1.1	0.8	-0.6	0.6	0.2
Mean num. licks in bursts	0.5	0.7	3.9	-0.2	-0.2	0.3	0.4	-0.4	-2.0
Cd content in liver	0.9	1.0	1.6	-0.7	0.8	1.0	-1.3	1.3	0.7
Co content in liver	0.1	0.1	0.2	0.4	0.3	0.1	-0.1	0.1	-0.3
Cu content in liver	2.4	2.9	4.2	1.6	-1.7	-1.5	1.7	-1.7	-2.0
Fe content in liver	1.3	1.5	1.9	-1.4	1.3	1.3	-1.2	1.2	1.0
K content in liver	0.8	0.7	1.2	0.7	-1.1	-0.8	0.8	-0.8	-0.8
Mg content in liver	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	0.1	-0.3
Mn content in liver	0.1	0.1	0.2	0.0	-0.3	-0.3	-0.1	0.1	0.5
Na content in liver	0.1	0.1	0.2	0.0	-0.5	-0.4	0.4	-0.4	0.2
Rb content in liver	0.1	0.1	0.3	0.5	-0.4	-0.4	0.1	-0.1	-0.2
Se content in liver	0.6	0.7	1.0	-1.0	0.8	1.0	-0.8	0.8	0.5
Sr content in liver	2.2	1.9	2.2	1.4	-1.4	-1.4	1.5	-1.5	-1.1
Zn content in liver	0.2	0.3	0.5	-0.7	0.2	0.4	-0.4	0.4	0.7
Bone: minimum diameter	7.5	13.7	17.5	4.2	-3.8	-4.1	3.6	-3.6	-2.7
Time in familiar zone, hab. session 1	0.3	0.3	0.5	-0.7	0.3	0.6	-0.6	0.6	-0.3
Time in novel zone, hab. session 1	0.2	0.2	0.3	0.6	-0.2	-0.6	0.4	-0.4	0.5
Total zone transitions, hab. session 1	0.2	0.2	0.4	-0.6	0.6	0.6	-0.4	0.4	-0.1
Total locomotion distance, hab. session 1	0.1	0.2	0.8	-0.0	0.2	0.2	0.2	-0.2	-0.9
Locomotion velocity, hab. session 1	0.1	0.1	0.5	0.1	0.1	0.1	0.2	-0.2	-0.7
Time in familiar zone, hab. session 2	0.1	0.1	0.5	0.3	-0.2	-0.1	-0.0	0.0	-0.7
Time in novel zone, hab. session 2	0.2	0.2	1.2	-0.3	0.1	-0.1	0.1	-0.1	1.1
Total zone transitions, hab. session 2	0.2	0.3	1.4	-0.4	0.2	0.4	-0.1	0.1	-1.2
Total locomotion distance, hab. session 2	0.2	0.3	0.8	-0.4	0.4	0.5	-0.3	0.3	-0.9
Locomotion velocity, hab. session 2	0.2	0.3	1.3	-0.2	0.2	0.3	-0.1	0.1	-1.2
Novel to familiar place preference ratio	1.0	1.1	2.3	1.5	-1.0	-1.3	0.8	-0.8	0.6
Novelty place preference	0.7	0.8	1.6	1.2	-0.7	-1.1	0.5	-0.5	1.0
Time in novel zone, NPP test	0.7	0.7	1.7	1.1	-0.5	-1.0	0.4	-0.4	1.3
Total zone transitions, NPP test	0.8	1.2	1.7	-1.2	1.2	1.3	-0.9	0.9	-0.9
Total locomotion distance, NPP test	1.8	2.4	3.4	-1.5	1.9	1.9	-1.6	1.6	0.3
Locomotion velocity, NPP test	0.9	1.3	2.0	-1.1	1.4	1.4	-1.2	1.2	-0.2
Intraocular pressure	7.5	10.9	16.2	-3.4	4.0	3.5	-2.9	2.9	2.8
Delta distance traveled before/after self-admin	0.3	0.3	1.3	-0.2	-0.0	0.2	0.4	-0.4	-1.1
Delta ambulatory time before/after self-admin	0.2	0.3	0.8	-0.2	0.1	0.2	0.6	-0.6	-0.9
Parametrial fat weight	0.2	0.5	1.2	-1.1	1.0	0.9	0.0	-0.0	-0.3
Pavlov. Cond. lever latency	0.1	0.2	0.8	-0.3	-0.2	-0.2	-0.1	0.1	0.9
Pavlov. Cond. magazine entry latency	0.1	0.2	0.6	0.2	0.3	0.4	-0.2	0.2	-0.8
Pavlov. Cond. change in total contacts	0.1	0.1	0.2	0.4	-0.0	-0.1	0.1	-0.1	-0.5
Pavlov. Cond. index score	0.3	0.4	1.1	0.7	-0.3	-0.3	0.6	-0.6	-1.1
Pavlov. Cond. latency score	0.3	0.4	1.1	0.7	-0.2	-0.2	0.5	-0.5	-1.1
Pavlov. Cond. lever contacts	0.1	0.2	0.4	-0.2	0.6	0.5	-0.3	0.3	-0.3
Pavlov. Cond. magazine entry number	0.1	0.2	0.7	-0.4	-0.0	-0.1	-0.2	0.2	0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.7	-0.8	0.7	0.8	-0.7	0.7	-0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.8	1.0	-0.6	-0.6	0.8	-0.8	-1.4
Pavlov. Cond. response bias	0.1	0.2	0.7	-0.1	0.4	0.5	-0.1	0.1	-0.8
Pavlov. Cond. lever latency	0.1	0.2	0.3	0.4	-0.5	-0.5	0.4	-0.4	-0.0
Pavlov. Cond. magazine entry latency	0.2	0.2	0.6	0.7	-0.5	-0.6	0.0	-0.0	0.4
Pavlov. Cond. change in total contacts	0.8	1.3	2.3	1.5	-1.1	-1.2	0.9	-0.9	-1.2
Pavlov. Cond. index score	0.2	0.2	0.5	0.7	-0.5	-0.6	0.3	-0.3	-0.3
Pavlov. Cond. latency score	0.2	0.2	0.5	0.7	-0.5	-0.6	0.3	-0.3	-0.3
Pavlov. Cond. lever contacts	0.1	0.1	0.1	-0.2	0.4	0.3	-0.4	0.4	0.1
Pavlov. Cond. magazine entry number	1.0	1.2	2.4	-1.5	1.3	1.4	-0.7	0.7	-0.1
Pavlov. Cond. intertrial magazine entries	2.3	3.5	7.2	-2.7	2.2	2.4	-1.2	1.2	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.7	0.8	-0.6	-0.7	0.4	-0.4	-0.2
Pavlov. Cond. response bias	0.0	0.0	0.0	0.1	0.1	0.0	-0.2	0.2	0.2
Time in closed arm before self-admin	1.4	1.8	2.7	1.6	-1.6	-1.6	0.9	-0.9	-1.1
Time in closed arm after self-admin	0.1	0.1	0.3	0.1	-0.1	-0.1	-0.2	0.2	-0.5
Time in open arm before self-admin	0.1	0.1	0.5	0.1	0.2	-0.0	0.0	-0.0	0.7
Time in open arm after self-admin	0.3	0.3	1.4	-0.0	0.1	0.0	-0.4	0.4	1.2
Bone: periosteal estimation	11.6	24.4	27.4	5.2	-5.2	-5.2	5.0	-5.0	-3.8
Bone: periosteal perimeter	10.1	17.4	20.5	4.3	-4.5	-4.3	4.1	-4.1	-3.6
Bone: post-yield work	8.2	12.1	13.5	3.4	-3.7	-3.7	3.6	-3.6	-2.8
Progressive ratio test 1 active lever presses	3.2	4.0	7.2	-2.1	2.1	1.8	-1.6	1.6	2.7
Progressive ratio test 1 breakpoint	2.8	3.5	6.5	-1.9	2.0	1.7	-1.4	1.4	2.5
Progressive ratio test 1 inactive lever presses	1.7	2.4	6.1	-1.2	0.9	1.0	-1.6	1.6	2.5
Progressive ratio test 2 active lever presses	1.6	1.8	6.1	-1.0	1.0	0.8	-1.1	1.1	2.5
Progressive ratio test 2 breakpoint	1.6	1.8	6.2	-1.0	0.9	0.7	-1.1	1.1	2.5
Progressive ratio test 2 inactive lever presses	1.3	2.1	5.7	-1.2	1.1	1.0	-1.3	1.3	2.4
Incentive Sensitization - Responses	0.2	0.3	0.6	0.7	-0.8	-0.7	-0.0	0.0	0.6
Incentive Sensitization - Breakpoint	0.2	0.3	0.6	0.6	-0.6	-0.6	-0.2	0.2	0.8
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.1	-0.2	0.3	0.2	-0.4	0.4	0.3
Progressive ratio	0.1	0.2	0.3	-0.6	0.4	0.5	-0.5	0.5	0.1
Food seeking constrained by brief footshock	0.3	0.4	1.3	-0.4	0.2	0.3	0.5	-0.5	-1.1
Seeking ratio, punishment vs. effort	0.1	0.2	0.6	0.1	-0.1	-0.1	0.5	-0.5	-0.8
Retroperitoneal fat weight	0.1	0.3	0.9	-0.9	0.4	0.6	0.1	-0.1	-0.5
Reaction time number correct	0.8	1.5	2.2	1.0	-0.7	-0.9	1.5	-1.5	-1.5
Reaction time mean minus median	5.0	12.3	14.3	-3.5	3.4	3.8	-3.6	3.6	3.2
Reaction time mean minus median AUC	3.5	8.8	10.2	-2.9	2.8	3.2	-2.9	2.9	3.1
Reaction time num false alarms	1.8	2.5	3.2	-1.8	1.4	1.6	-1.4	1.4	1.8
Reaction time num false alarms AUC	2.6	4.1	4.6	-2.1	1.9	2.1	-1.9	1.9	2.1
Reaction time trials correct on left	0.8	1.5	2.2	1.0	-0.7	-0.9	1.5	-1.5	-1.5
Reaction time trials on left	0.6	1.1	1.8	0.9	-0.6	-0.7	1.3	-1.3	-1.4
Reaction time mean	0.8	1.3	2.1	-1.0	1.0	1.1	-1.2	1.2	1.4
Reaction time mean AUC	0.5	0.8	1.4	-0.8	0.7	0.9	-0.9	0.9	1.2
Median of all reaction times	0.0	0.0	0.1	0.0	-0.1	-0.1	-0.1	0.1	0.4
Reaction time omissions	9.3	13.6	15.3	-3.9	3.6	3.9	-3.8	3.8	3.0
Reaction time false alarm rate	2.9	3.9	5.6	-2.0	1.6	1.9	-2.0	2.0	2.4
Reaction time premature initiation rate	3.5	4.8	6.7	-2.5	2.1	2.1	-1.9	1.9	2.6
Reaction time premature initiations	1.4	2.5	3.5	-1.9	1.7	1.6	-1.1	1.1	1.8
Std. dev. reaction times	5.4	9.9	10.8	-3.0	3.0	3.3	-3.2	3.2	3.1
Reaction time trials completed	0.6	1.1	1.8	0.9	-0.6	-0.7	1.3	-1.3	-1.4
Reaction time trials AUC	1.0	1.9	2.9	1.2	-0.9	-1.0	1.6	-1.6	-1.7
Run reversals in cocaine runway, females	0.7	0.7	1.8	-0.3	0.5	0.4	-1.0	1.0	1.4
Run reversals in cocaine runway, males	0.8	0.8	1.1	-1.0	0.9	0.9	-0.9	0.9	0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.2	-0.4	0.1	0.1	-0.0	0.0	0.2
Latency to leave start box in cocaine runway, F	1.3	1.5	2.4	-1.3	1.1	1.0	-1.2	1.2	1.6
Latency to leave start box in cocaine runway, M	2.3	2.2	2.9	1.2	-1.4	-1.2	1.6	-1.6	-1.7
Std. dev. time between licks in bursts	0.7	0.9	1.7	-1.0	1.3	0.9	-0.6	0.6	1.1
Total sessions with >9 infusions	0.7	0.9	1.9	-0.8	0.7	0.8	-0.9	0.9	1.4
Short access day 1 total inactive lever presses	1.2	1.6	2.3	-1.3	1.1	1.2	-1.2	1.2	1.5
Short access day 10 total inactive lever presses	0.1	0.2	0.4	-0.6	0.4	0.4	-0.5	0.5	0.6
Short access day 1 total infusions	0.2	0.3	0.7	-0.2	0.2	0.4	-0.5	0.5	0.9
Short access day 10 total infusions	0.5	0.6	0.8	-0.9	0.8	0.9	-0.8	0.8	0.8
Short access total infusions	1.0	1.3	2.4	-1.1	1.0	1.1	-1.0	1.0	1.6
Short access day 1 locomotion	0.1	0.1	0.4	0.3	-0.3	-0.3	0.1	-0.1	0.6
Short access day 10 total locomotion	0.2	0.4	2.1	-0.4	0.3	0.0	-0.0	0.0	1.5
Short access total locomotion	0.4	0.5	2.6	-0.6	0.4	0.2	-0.2	0.2	1.6
One hour access (0.3 mA shock)	0.3	0.4	1.3	-0.2	-0.0	0.2	-0.7	0.7	1.1
Compulsive drug intake	0.1	0.1	0.2	-0.2	0.4	0.4	-0.4	0.4	0.0
One hour access (shock baseline)	0.1	0.1	0.3	0.4	-0.6	-0.4	0.0	-0.0	0.4
Social response proportion	1.0	1.1	1.8	-0.6	0.7	0.7	-1.3	1.3	1.3
Social responses	10.0	12.9	18.3	-3.3	3.2	3.2	-3.7	3.7	4.3
Social time	0.9	1.3	2.2	-0.4	0.6	0.9	-1.5	1.5	1.3
Soleus weight	0.9	2.8	3.5	1.4	-1.9	-1.7	1.8	-1.8	-1.2
Bone: stiffness	14.5	23.5	30.0	5.5	-5.1	-5.2	4.6	-4.6	-3.9
Tibialis anterior weight	2.2	7.3	9.8	2.8	-3.1	-3.0	2.9	-2.9	-0.9
Time to tail flick, vehicle, before self-admin	1.8	1.9	3.5	-1.5	1.9	1.7	-1.0	1.0	0.8
Time to tail flick, vehicle, after self-admin	0.4	0.6	1.8	0.0	0.2	-0.1	-0.9	0.9	1.3
Time to tail flick, test, before self-admin	0.7	0.7	1.6	-0.6	0.5	0.7	-1.3	1.3	0.2
Time to tail flick, test, after self-admin	0.2	0.2	0.7	0.4	-0.9	-0.5	0.1	-0.1	-0.4
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.5	0.7	-0.6	-0.7	0.1	-0.1	-0.0
Delta time to tail flick, test, before/after SA	0.3	0.3	0.6	0.5	-0.7	-0.6	0.6	-0.6	0.3
Tibia length	5.9	16.2	19.9	4.5	-4.1	-4.3	4.1	-4.1	-3.0
Ambulatory time before self-admin	1.2	1.8	2.3	-1.4	1.4	1.3	-1.2	1.2	1.5
Ambulatory time after self-admin	0.5	0.6	1.3	-1.1	1.0	0.9	-0.1	0.1	0.3
Bone: tissue strength	0.4	0.4	0.5	0.7	-0.6	-0.7	0.6	-0.6	-0.4
Total heroin consumption	1.1	1.3	1.9	1.1	-1.1	-1.4	1.3	-1.3	-0.3
Bone: trabecular number	4.8	7.9	12.0	3.0	-2.7	-2.4	2.6	-2.6	-3.5
Bone: trabecular spacing	1.8	2.4	5.9	-1.6	1.2	1.1	-1.3	1.3	2.4
Bone: trabecular thickness	0.3	0.4	0.6	-0.2	0.5	0.6	-0.8	0.8	0.6
Bone: trabecular tissue density	0.1	0.2	0.7	-0.3	0.3	0.0	-0.2	0.2	0.8
Water consumed over 24 hours	0.3	0.4	0.8	0.3	-0.8	-0.4	0.5	-0.5	-0.9
Number of responses in last shaping day	0.3	0.3	0.9	0.3	-0.5	-0.5	0.3	-0.3	1.0