LOC108351012

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	mRNA stability	LOC108351012	0.13	0.08	1.1e-07	0.07	0.07	0.07	0.07	1.7e-08	2.0e-08	1.6e-08	2.3e-08
2	Adipose	isoform ratio	XR_010066579.1	0.04	0.03	3.3e-03	0.01	0.01	0.01	0.01	7.4e-03	7.8e-03	1.2e-02	1.0e-02
3	Adipose	isoform ratio	XR_010066578.1	0.17	0.1	3.8e-13	0.11	0.12	0.11	0.11	4.4e-12	1.2e-12	1.6e-12	3.1e-12
4	Adipose	isoform ratio	XR_010066580.1	0.13	0.08	6.9e-12	0.04	0.09	0.1	0.09	1.0e-05	1.2e-10	4.0e-11	1.6e-10
5	Adipose	alternative polyA	XR_010066580.1	0.11	0.07	1.3e-09	0.04	0.07	0.09	0.08	8.4e-05	6.1e-08	2.0e-10	3.4e-09
6	Adipose	alternative polyA	XR_010066579.1	0.11	0.07	1.3e-09	0.04	0.08	0.09	0.08	7.7e-05	7.5e-09	2.2e-10	3.9e-09

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.2	0.3	1.0	0.1	-1.0	-0.5	0.7	0.3	-0.4
Area under the delay curve	0.3	0.3	0.8	-0.9	-0.1	0.7	-0.5	-0.5	0.5
BMI with tail	0.4	1.4	6.6	1.1	2.6	-0.1	-0.8	-0.0	0.1
BMI without tail	0.2	0.7	3.0	0.5	1.7	0.2	-0.7	-0.3	0.3
Body weight	0.2	1.0	4.5	0.8	2.1	-0.0	-0.7	-0.2	0.2
Weight adjusted by age	0.4	0.5	1.4	1.2	0.6	-0.7	0.4	0.7	-0.7
Bone surface	0.1	0.2	0.5	-0.4	-0.7	0.1	-0.0	-0.4	0.4
Bone volume	0.0	0.0	0.0	-0.1	-0.2	-0.1	0.0	-0.1	0.1
Breakpoint value in progressive ratio session	0.0	0.0	0.1	0.2	-0.1	-0.2	0.2	0.1	-0.1
Number of licking bursts	0.1	0.2	0.5	0.7	0.5	-0.6	0.2	0.3	-0.3
Context. condit. distance diff. score	1.0	1.2	2.0	0.6	-0.7	-0.8	1.3	1.4	-1.4
Locomotion velocity, session 1	2.4	2.6	4.2	0.9	-1.8	-1.5	2.1	1.6	-1.6
Locomotion distance, session 1	0.3	0.3	0.4	0.6	-0.1	-0.6	0.6	0.6	-0.6
Locomotion velocity, session 2	2.5	2.9	4.4	1.0	-1.8	-1.7	2.1	1.7	-1.8
Locomotion distance, session 2	1.1	1.5	2.1	-1.0	0.8	1.2	-1.4	-1.4	1.4
Locomotion velocity, session 3	0.2	0.3	1.0	-0.0	-1.0	-0.4	0.7	0.1	-0.2
Locomotion distance, session 3	0.5	0.6	0.8	-0.8	0.1	0.9	-0.8	-0.8	0.8
Stereotopy head waving bouts, day 3	0.1	0.1	0.4	0.6	0.0	-0.6	0.3	0.0	-0.0
Stereotopy head waving duration, day 3	1.2	1.4	2.6	1.4	-0.3	-1.6	1.3	1.0	-1.0
Locomotion velocity, session 7	0.4	0.4	1.2	-1.1	-0.5	1.1	-0.2	-0.0	-0.0
Locomotion distance, session 7	1.9	2.5	5.1	-2.2	-0.4	2.2	-1.4	-1.2	1.2
Stereotopy head waving bouts, day 7	1.0	1.1	1.9	0.6	-1.3	-1.1	1.4	0.8	-0.9
Stereotopy head waving duration, day 7	1.2	1.4	2.4	0.8	-1.3	-1.3	1.5	1.0	-1.0
Locomotion velocity, session 8	1.3	1.6	2.8	0.2	-1.7	-0.6	1.5	1.5	-1.5
Locomotion distance, session 8	0.1	0.1	0.3	-0.1	-0.2	0.1	0.4	0.5	-0.5
Degree of sensitization distance	0.2	0.3	0.7	-0.7	0.1	0.9	-0.5	-0.2	0.2
Degree of sensitization stereotypy	0.4	0.5	0.9	0.3	-0.9	-0.7	0.9	0.5	-0.5
Conditioned locomotion	1.2	1.4	2.2	1.4	0.4	-1.1	1.0	1.5	-1.5
Cocaine response after cond. corrected	2.9	3.5	5.1	-1.2	1.5	1.6	-2.2	-2.3	2.3
Cocaine response after cond. not corrected	2.4	2.8	3.8	-0.7	1.8	1.2	-2.0	-1.9	2.0
Cocaine response before conditioning	0.4	0.5	0.7	0.8	0.3	-0.7	0.6	0.8	-0.8
Saline control response	1.5	1.9	3.6	-1.9	-0.1	1.9	-1.4	-1.1	1.1
Bone: connectivity density	0.3	0.5	2.0	-0.6	-1.4	-0.0	0.3	-0.4	0.4
Bone: cortical apparent density	1.5	2.0	3.1	0.7	-1.6	-1.2	1.8	1.5	-1.5
Bone: cortical area	0.5	0.7	1.9	-0.3	1.4	0.9	-1.1	-0.5	0.5
Bone: cortical porosity	2.7	2.9	3.9	2.0	0.0	-1.9	1.7	1.9	-1.9
Bone: cortical porosity	2.8	3.0	4.0	1.8	-0.4	-1.9	1.8	2.0	-2.0
Bone: cortical thickness	0.6	1.1	5.0	0.4	2.2	0.5	-1.0	0.0	0.0
Bone: cortical thickness	0.7	0.8	2.9	1.0	1.7	-0.2	-0.2	0.7	-0.7
Bone: cortical tissue density	1.8	2.4	3.7	0.8	-1.7	-1.4	1.9	1.6	-1.7
Condit. Reinf. active minus inactive responses	0.3	0.3	0.7	-0.1	0.8	0.3	-0.7	-0.6	0.6
Condit. Reinf. active-inactive response ratio	0.3	0.3	0.9	-0.0	0.9	0.4	-0.7	-0.5	0.5
Condit. Reinf. active responses	0.5	0.6	1.5	-0.1	1.2	0.5	-0.9	-0.7	0.7
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.4	0.2	0.5	-0.5	-0.3	0.3
Incentive salience index mean	0.7	0.9	2.5	0.1	1.6	0.4	-1.1	-0.9	0.9
Condit. Reinf. lever presses	0.7	1.0	2.8	0.1	1.7	0.5	-1.1	-0.9	0.9
Condit. Reinf. active minus inactive responses	0.7	0.9	2.3	-1.2	0.4	1.5	-1.1	-0.5	0.5
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.1	-0.9	0.0	1.1	-0.7	-0.3	0.3
Condit. Reinf. active responses	0.2	0.3	0.7	-0.5	0.5	0.8	-0.6	-0.1	0.1
Condit. Reinf. inactive responses	0.1	0.1	0.5	0.4	0.7	-0.1	-0.1	0.0	-0.0
Condit. Reinf. lever presses	1.6	2.1	3.2	-1.8	-0.6	1.5	-1.3	-1.7	1.6
Condit. Reinf. lever reinforcers received	0.4	0.5	1.1	-0.8	0.3	1.1	-0.8	-0.5	0.5
Conditioned reinforcement - actives	2.3	3.9	5.5	-1.7	1.7	2.1	-2.3	-2.0	2.0
Conditioned reinforcement - inactives	0.0	0.0	0.1	0.1	0.3	0.1	-0.2	-0.1	0.1
Conditioned locomotion	0.8	1.0	1.5	-0.8	1.0	1.1	-1.2	-1.0	1.0
Patch foraging indifference point 0 sec	0.2	0.3	0.5	-0.2	0.7	0.4	-0.7	-0.5	0.5
Patch foraging indifference point AUC	0.1	0.1	0.4	-0.1	-0.6	-0.1	0.3	0.1	-0.1
Delay disc. indifference point, 0s delay	0.6	0.6	1.8	-1.3	-0.6	0.9	-0.4	-0.5	0.5
Delay disc. indifference point, 16s delay	0.7	0.7	1.2	-0.3	1.1	0.7	-1.0	-0.9	0.9
Delay disc. indifference point, 2s delay	0.0	0.0	0.1	-0.4	-0.3	0.2	0.0	0.1	-0.1
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.4	-0.4	0.2	0.2	0.4	-0.4
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.4	0.1	0.4	-0.3	-0.2	0.2
Delay disc. indifference point, 8s delay	0.2	0.2	0.5	-0.7	-0.0	0.6	-0.4	-0.4	0.4
Indifference point function ln k	0.1	0.2	0.7	0.0	0.8	0.3	-0.5	-0.3	0.3
Indifference point function log k	0.1	0.2	0.7	0.0	0.8	0.3	-0.5	-0.3	0.3
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.0	0.6	0.3	-0.5	-0.4	0.4
Patch foraging total patch changes 12 sec	0.3	0.4	1.5	-0.1	-1.2	-0.3	0.8	0.4	-0.5
Patch foraging total patch changes 18 sec	0.1	0.1	0.2	-0.1	0.5	0.2	-0.4	-0.4	0.4
Patch foraging total patch changes 24 sec	0.2	0.3	1.2	0.4	1.1	0.0	-0.4	-0.1	0.2
Patch foraging total patch changes 6 sec	0.5	0.7	0.9	-0.9	0.2	0.9	-0.8	-0.9	0.9
Patch foraging time to switch 0 sec	0.5	1.0	1.8	0.4	-1.3	-0.9	1.3	0.8	-0.9
Patch foraging water rate 0 sec	0.4	0.7	3.1	0.5	1.8	0.3	-0.9	-0.4	0.4
Patch foraging water rate 12 sec	0.7	1.5	4.0	-0.2	2.0	0.9	-1.5	-1.0	1.1
Patch foraging water rate 18 sec	0.3	0.5	0.8	0.7	0.2	-0.6	0.6	0.9	-0.9
Patch foraging water rate 24 sec	0.2	0.3	0.5	0.7	0.2	-0.6	0.5	0.6	-0.6
Patch foraging water rate 6 sec	0.3	0.4	1.9	0.4	1.4	0.2	-0.6	-0.1	0.1
Seeking ratio, delayed vs. immediate footshock	1.1	1.4	3.4	-0.3	1.8	0.9	-1.4	-0.9	1.0
Distance traveled before self-admin	0.1	0.2	0.5	0.7	0.5	-0.5	-0.0	-0.1	0.2
Distance traveled after self-admin	0.3	0.4	1.4	0.5	1.2	-0.1	-0.5	-0.4	0.4
Extensor digitorum longus weight	0.3	1.4	5.5	1.4	2.4	-0.4	-0.3	0.5	-0.5
Bone: elastic displacement	0.6	0.7	1.5	1.2	0.3	-1.2	0.8	0.7	-0.7
Bone: elastic work	0.1	0.1	0.2	0.4	0.4	-0.2	0.1	0.2	-0.2
Bone: endosteal estimation	0.2	0.4	0.8	-0.4	-0.4	0.1	-0.4	-0.9	0.9
Bone: endosteal perimeter	0.7	1.6	2.6	-1.4	-0.8	0.9	-0.9	-1.6	1.6
Epididymis fat weight	0.1	0.3	0.9	-0.9	-0.4	0.7	-0.3	-0.4	0.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	-0.3	0.0	0.3	-0.1	-0.1	0.1
Delta time in open arm before/after self-admin	0.4	0.4	0.8	-0.4	0.4	0.3	-0.6	-0.9	0.9
Diff in mean of infusions in LGA sessions	0.4	0.5	1.2	-1.1	0.1	1.0	-0.7	-0.4	0.4
Delay discount exponential model param	0.3	0.3	0.8	0.9	0.1	-0.7	0.5	0.4	-0.4
Extinction: sum of active levers before priming	0.9	1.0	2.7	1.6	0.4	-1.3	0.7	0.7	-0.7
Active lever presses in extinction session 6	1.9	1.9	2.7	-1.0	1.4	1.3	-1.6	-1.4	1.4
Bone: final force	0.2	0.3	0.4	-0.6	-0.2	0.5	-0.5	-0.6	0.6
Bone: final moment	0.2	0.4	0.5	-0.7	-0.0	0.6	-0.6	-0.7	0.7
Food consumed during 24 hour testing period	2.9	4.0	5.7	-2.2	0.3	2.4	-2.1	-2.0	2.0
Glucose	0.4	0.7	0.9	-0.8	0.3	0.9	-0.9	-0.9	0.9
Heart weight	0.8	1.3	2.9	1.7	1.7	-0.9	0.3	0.8	-0.8
Delay discount hyperbolic model param	0.2	0.2	0.6	0.8	0.2	-0.6	0.3	0.3	-0.3
Intermittent access intake day 1-15 change	0.4	0.9	1.3	-0.8	0.8	1.0	-1.1	-1.0	1.0
Intermittent access intake escalation	0.2	0.5	0.8	-0.3	0.9	0.6	-0.9	-0.7	0.7
Intermittent access intake escalation 2	0.1	0.2	0.2	-0.2	0.4	0.4	-0.5	-0.4	0.4
Intermitt. access day 1 inactive lever presses	0.2	0.8	1.9	-0.3	1.4	0.9	-1.1	-0.7	0.7
Intermitt. access day 15 inactive lever presses	0.1	0.3	0.9	0.8	1.0	-0.2	-0.1	0.3	-0.3
Intermitt. access escalation Index	0.5	0.6	0.9	1.0	-0.1	-0.8	0.8	0.9	-0.9
Intermittent access day 1 total infusions	0.3	0.5	0.8	0.9	-0.1	-0.8	0.7	0.7	-0.7
Intermittent access day 15 total infusions	0.1	0.2	0.4	0.6	0.7	-0.2	-0.0	0.2	-0.2
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	0.4	0.2	-0.2	0.1	0.2	-0.2
Intermittent access total infusions	0.2	0.3	0.6	0.8	0.1	-0.6	0.5	0.5	-0.5
Intermittent access day 1 locomotion	0.2	0.2	0.4	0.6	0.0	-0.5	0.4	0.5	-0.5
Intermittent access day 15 total locomotion	0.3	0.6	0.7	-0.8	0.5	0.8	-0.8	-0.8	0.8
Intermittent access total locomotion	0.2	0.2	0.5	0.7	0.2	-0.5	0.4	0.4	-0.4
Intermittent access standard deviation	0.6	1.2	3.1	-0.2	1.8	0.9	-1.3	-0.9	0.9
Left kidney weight	1.7	8.1	28.0	0.3	5.3	1.8	-3.3	-1.7	1.8
Right kidney weight	0.9	4.3	16.9	0.7	4.1	0.9	-2.2	-1.1	1.1
Cocaine induced anxiety	0.9	1.3	3.6	1.9	0.8	-1.0	0.5	1.1	-1.1
Post-drug Anxiety	2.3	2.4	6.5	2.5	1.0	-1.3	0.8	1.5	-1.5
Baseline Anxiety	0.0	0.0	0.2	0.1	0.4	0.1	-0.2	-0.1	0.1
Tail length	0.0	0.0	0.0	0.1	-0.0	-0.2	0.1	-0.0	0.0
Length with tail	0.1	0.4	0.7	-0.3	0.9	0.5	-0.7	-0.6	0.6
Length without tail	0.8	2.6	4.6	-0.7	2.2	1.5	-2.0	-1.5	1.5
Times rat made contact with spout	3.4	4.0	6.0	-1.9	0.5	1.9	-2.1	-2.5	2.5
Lifetime Intake	0.0	0.0	0.0	0.1	0.0	-0.1	0.1	0.1	-0.1
Liver weight, left	0.2	0.4	0.8	-0.9	-0.5	0.7	-0.4	-0.5	0.5
Liver weight, right	0.2	0.4	0.8	-0.9	-0.6	0.7	-0.4	-0.5	0.5
Locomotor activity	1.7	2.6	3.5	-1.9	-0.1	1.7	-1.7	-1.8	1.8
Locomotor testing distance	1.9	3.5	4.5	-2.0	0.2	2.0	-2.0	-2.1	2.1
Locomotor testing rearing	2.3	4.5	6.2	-2.5	0.1	2.4	-2.2	-2.3	2.3
Locomotion in novel chamber	3.5	4.4	6.1	-1.4	2.0	1.8	-2.5	-2.3	2.3
Locomotion in novel chamber post-restriction	0.5	0.8	2.7	1.6	0.6	-1.2	0.5	0.4	-0.4
Fecal boli incidents, locomotor time 1	0.4	0.5	1.3	-1.1	0.1	1.0	-0.7	-0.4	0.4
Change in fecal boli incidents, locomotor task	0.1	0.1	0.4	-0.3	-0.6	0.0	0.2	0.1	-0.1
Time >=10cm from walls, locomotor time 1	1.4	1.5	2.5	1.3	-1.0	-1.6	1.4	0.9	-0.9
Bouts of movement, locomotor time 1	0.4	0.5	1.0	-0.8	-1.0	0.2	-0.0	-0.7	0.7
Total resting periods, locomotor time 1	0.2	0.2	0.6	-0.5	-0.8	-0.0	0.1	-0.6	0.5
Rest time, locomotor task time 1	0.2	0.2	0.7	-0.8	-0.3	0.6	-0.3	-0.3	0.3
Distance moved, locomotor task time 1	1.0	1.4	2.2	1.5	-0.3	-1.3	1.2	1.3	-1.2
Vertical activity count, locomotor time 1	0.0	0.1	0.4	0.4	0.6	-0.0	-0.2	0.2	-0.2
Time >=10cm from walls, locomotor time 2	0.3	0.5	0.8	0.9	0.1	-0.7	0.6	0.7	-0.7
Bouts of movement, locomotor time 2	0.5	0.8	1.2	1.0	-0.7	-1.1	1.1	0.6	-0.6
Total resting periods, locomotor time 2	0.3	0.5	0.9	0.8	-0.7	-0.9	0.9	0.3	-0.4
Rest time, locomotor task time 2	0.2	0.3	0.7	-0.8	-0.4	0.6	-0.2	-0.5	0.4
Distance moved, locomotor task time 2	0.4	0.4	1.1	1.0	0.9	-0.5	0.0	0.5	-0.5
Vertical activity count, locomotor time 2	0.5	0.6	2.0	-0.1	1.4	0.6	-1.0	-0.4	0.4
Light reinforcement 1	0.2	0.4	1.0	1.0	0.6	-0.7	0.4	0.6	-0.6
Light reinforcement 2	0.4	0.6	2.5	0.8	1.6	-0.2	-0.3	0.3	-0.3
Bone: marrow area	0.2	0.4	1.0	-0.4	-0.3	0.1	-0.5	-1.0	1.0
Bone: maximum diameter	0.0	0.1	0.3	0.3	0.5	-0.2	-0.2	-0.1	0.1
Bone: maximum force	0.1	0.2	0.3	-0.6	-0.1	0.5	-0.5	-0.6	0.6
Bone: maximum moment	0.2	0.3	0.4	-0.6	0.1	0.6	-0.7	-0.6	0.6
Mean time between licks in bursts	0.3	0.7	2.7	-1.1	-1.6	0.6	0.3	0.1	-0.1
Mean num. licks in bursts	1.3	2.1	2.8	-1.4	0.4	1.5	-1.6	-1.7	1.7
Cd content in liver	0.2	0.3	0.8	-0.3	-0.9	0.0	0.5	0.5	-0.5
Co content in liver	0.1	0.2	0.3	-0.6	-0.2	0.5	-0.4	-0.4	0.4
Cu content in liver	2.3	2.8	4.5	-2.1	-0.7	1.8	-1.4	-1.8	1.8
Fe content in liver	0.3	0.3	0.9	0.8	0.9	-0.6	-0.1	-0.2	0.2
K content in liver	3.1	3.0	4.8	-2.2	-0.7	1.8	-1.5	-1.9	1.8
Mg content in liver	4.4	4.5	5.9	-2.2	0.6	2.4	-2.3	-2.3	2.3
Mn content in liver	0.1	0.2	0.3	0.1	-0.5	-0.2	0.5	0.4	-0.4
Na content in liver	0.3	0.3	0.7	-0.8	-0.8	0.4	-0.2	-0.5	0.5
Rb content in liver	0.5	0.6	1.0	-1.0	-0.2	0.9	-0.7	-0.8	0.8
Se content in liver	0.4	0.4	1.0	-1.0	-0.4	0.9	-0.5	-0.5	0.4
Sr content in liver	0.0	0.0	0.0	0.2	0.0	-0.2	0.1	0.0	-0.0
Zn content in liver	1.3	1.4	3.0	-1.7	-1.1	1.4	-0.7	-0.9	0.9
Bone: minimum diameter	1.7	3.1	4.2	-1.7	0.6	1.8	-2.0	-2.0	2.0
Time in familiar zone, hab. session 1	0.7	0.7	1.0	0.5	-0.7	-0.7	1.0	1.0	-1.0
Time in novel zone, hab. session 1	0.8	0.8	1.3	-0.9	-0.2	0.7	-0.8	-1.1	1.1
Total zone transitions, hab. session 1	0.4	0.5	1.0	0.9	-0.1	-1.0	0.7	0.6	-0.6
Total locomotion distance, hab. session 1	0.6	0.8	1.8	1.3	0.7	-1.2	0.6	0.7	-0.7
Locomotion velocity, hab. session 1	0.4	0.6	1.2	1.1	0.5	-1.0	0.6	0.6	-0.6
Time in familiar zone, hab. session 2	0.9	0.9	2.1	-1.4	-0.8	1.3	-0.6	-0.7	0.7
Time in novel zone, hab. session 2	0.4	0.4	0.9	1.0	0.4	-1.0	0.5	0.3	-0.3
Total zone transitions, hab. session 2	0.4	0.5	0.6	-0.8	-0.0	0.7	-0.6	-0.8	0.8
Total locomotion distance, hab. session 2	0.1	0.2	0.4	-0.1	0.6	0.3	-0.5	-0.4	0.4
Locomotion velocity, hab. session 2	0.1	0.2	0.5	-0.1	0.7	0.3	-0.5	-0.4	0.4
Novel to familiar place preference ratio	2.5	2.7	3.8	-1.2	1.1	1.5	-1.9	-1.9	2.0
Novelty place preference	1.5	1.7	2.5	-0.9	0.8	1.1	-1.5	-1.6	1.6
Time in novel zone, NPP test	1.4	1.5	2.4	-0.9	0.7	1.0	-1.4	-1.5	1.5
Total zone transitions, NPP test	0.2	0.3	1.2	0.7	1.1	-0.3	-0.2	0.1	-0.1
Total locomotion distance, NPP test	0.2	0.3	1.5	0.5	1.2	-0.1	-0.4	-0.2	0.2
Locomotion velocity, NPP test	0.4	0.5	2.4	0.6	1.5	-0.0	-0.5	-0.2	0.2
Intraocular pressure	0.3	0.4	0.6	-0.5	0.5	0.7	-0.8	-0.6	0.6
Delta distance traveled before/after self-admin	0.6	0.6	1.3	-0.3	1.2	0.7	-1.0	-0.6	0.6
Delta ambulatory time before/after self-admin	0.5	0.6	1.0	-0.4	1.0	0.7	-0.9	-0.7	0.7
Parametrial fat weight	0.0	0.1	0.2	0.4	-0.1	-0.5	0.3	0.3	-0.3
Pavlov. Cond. lever latency	0.5	0.7	2.9	-0.7	-1.7	0.2	0.6	0.4	-0.5
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.3	-0.6	0.0	-0.0	-0.5	0.5
Pavlov. Cond. change in total contacts	0.0	0.0	0.0	0.0	0.2	-0.0	-0.1	-0.1	0.1
Pavlov. Cond. index score	0.2	0.2	0.5	0.1	0.7	0.0	-0.5	-0.6	0.6
Pavlov. Cond. latency score	0.3	0.3	0.7	0.1	0.8	0.1	-0.6	-0.7	0.7
Pavlov. Cond. lever contacts	0.4	0.5	2.1	0.6	1.4	-0.2	-0.5	-0.4	0.4
Pavlov. Cond. magazine entry number	0.1	0.1	0.3	0.1	0.5	0.2	-0.1	0.4	-0.4
Pavlov. Cond. intertrial magazine entries	1.2	1.4	2.0	-1.1	0.8	1.4	-1.4	-1.2	1.2
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	0.7	0.1	0.9	0.1	-0.6	-0.7	0.7
Pavlov. Cond. response bias	0.1	0.1	0.1	0.4	0.4	-0.4	-0.1	-0.3	0.3
Pavlov. Cond. lever latency	3.3	4.5	5.9	2.4	0.2	-2.3	2.1	2.4	-2.4
Pavlov. Cond. magazine entry latency	4.1	5.0	8.2	-2.9	-1.3	2.3	-1.7	-2.4	2.4
Pavlov. Cond. change in total contacts	2.6	4.2	6.7	-2.6	-0.5	2.4	-1.9	-2.1	2.1
Pavlov. Cond. index score	5.0	6.7	10.2	-3.2	-1.0	2.8	-2.3	-2.9	2.9
Pavlov. Cond. latency score	4.9	6.5	9.6	-3.1	-0.9	2.7	-2.2	-2.9	2.8
Pavlov. Cond. lever contacts	2.7	3.7	4.9	-2.2	-0.3	2.0	-1.8	-2.2	2.2
Pavlov. Cond. magazine entry number	3.7	4.5	8.2	2.9	1.8	-2.1	1.4	2.2	-2.1
Pavlov. Cond. intertrial magazine entries	1.9	2.8	4.3	1.8	0.1	-1.6	1.6	2.1	-2.1
Pavlov. Cond. lever-magazine prob. diff.	5.6	7.5	11.4	-3.4	-1.0	2.9	-2.4	-3.0	3.0
Pavlov. Cond. response bias	3.1	4.2	6.7	-2.6	-0.9	2.2	-1.7	-2.2	2.2
Time in closed arm before self-admin	0.7	0.9	1.3	0.7	-0.7	-0.7	1.0	1.2	-1.2
Time in closed arm after self-admin	0.8	0.9	1.5	0.8	-0.4	-0.7	1.0	1.2	-1.2
Time in open arm before self-admin	1.0	1.1	1.7	-1.3	0.0	1.1	-1.0	-1.1	1.1
Time in open arm after self-admin	1.8	2.0	3.5	-0.9	0.9	1.0	-1.5	-1.9	1.9
Bone: periosteal estimation	0.2	0.5	0.7	-0.2	0.8	0.3	-0.8	-0.8	0.8
Bone: periosteal perimeter	0.3	0.6	0.9	-0.7	0.2	0.6	-0.8	-1.0	1.0
Bone: post-yield work	0.2	0.3	0.6	-0.4	-0.2	0.2	-0.4	-0.8	0.8
Progressive ratio test 1 active lever presses	0.2	0.2	0.9	0.6	1.0	-0.1	-0.3	-0.0	0.0
Progressive ratio test 1 breakpoint	0.2	0.2	1.0	0.6	1.0	-0.2	-0.3	0.0	0.0
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.5	0.6	0.7	-0.2	-0.1	0.2	-0.2
Progressive ratio test 2 active lever presses	0.1	0.2	0.7	0.5	0.8	-0.1	-0.2	0.0	0.0
Progressive ratio test 2 breakpoint	0.2	0.3	0.7	0.8	0.8	-0.4	-0.0	0.2	-0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.0	0.3	0.1	-0.2	-0.1	0.1
Incentive Sensitization - Responses	0.0	0.0	0.0	0.1	0.1	-0.1	-0.0	-0.0	0.0
Incentive Sensitization - Breakpoint	0.0	0.0	0.0	0.1	0.1	-0.0	-0.0	-0.0	0.0
Sum of active levers in priming session hrs 5-6	0.4	0.3	1.1	1.0	0.5	-0.8	0.2	0.0	-0.0
Progressive ratio	0.2	0.3	0.4	-0.3	0.6	0.4	-0.7	-0.6	0.6
Food seeking constrained by brief footshock	1.4	1.7	3.7	0.2	-1.9	-0.9	1.6	1.2	-1.3
Seeking ratio, punishment vs. effort	1.3	1.9	4.3	0.3	-2.1	-1.1	1.7	1.2	-1.2
Retroperitoneal fat weight	0.0	0.1	0.2	0.2	-0.5	-0.4	0.5	0.4	-0.4
Reaction time number correct	0.7	1.3	1.7	1.3	0.1	-1.2	1.1	1.2	-1.2
Reaction time mean minus median	1.6	3.9	7.0	-2.6	-0.5	2.3	-1.7	-2.0	2.0
Reaction time mean minus median AUC	1.0	2.4	4.6	-2.1	-0.5	1.9	-1.2	-1.5	1.5
Reaction time num false alarms	1.8	2.6	3.5	-1.5	0.9	1.8	-1.9	-1.7	1.7
Reaction time num false alarms AUC	2.3	3.6	5.0	-1.6	1.4	2.1	-2.2	-2.0	2.0
Reaction time trials correct on left	0.7	1.3	1.7	1.3	0.1	-1.2	1.1	1.2	-1.2
Reaction time trials on left	0.5	1.0	1.4	1.2	0.1	-1.1	1.0	1.1	-1.1
Reaction time mean	1.5	2.4	4.5	-2.1	-0.7	1.7	-1.2	-1.6	1.6
Reaction time mean AUC	1.1	1.7	3.4	-1.8	-0.9	1.4	-0.9	-1.3	1.3
Median of all reaction times	0.8	1.2	2.3	-1.5	-0.8	1.1	-0.7	-1.1	1.1
Reaction time omissions	2.7	3.9	6.0	-2.4	0.2	2.4	-1.9	-2.0	2.0
Reaction time false alarm rate	3.6	5.0	6.8	-2.0	1.3	2.4	-2.6	-2.4	2.4
Reaction time premature initiation rate	0.4	0.5	1.1	-1.0	-0.3	0.9	-0.6	-0.6	0.6
Reaction time premature initiations	0.0	0.0	0.2	-0.3	-0.4	0.1	0.1	0.1	-0.1
Std. dev. reaction times	2.4	4.5	7.6	-2.8	-0.3	2.5	-1.9	-2.2	2.2
Reaction time trials completed	0.5	1.0	1.4	1.2	0.1	-1.1	1.0	1.1	-1.1
Reaction time trials AUC	0.4	0.8	1.2	1.1	0.2	-0.9	0.8	1.0	-1.0
Run reversals in cocaine runway, females	0.6	0.6	1.0	-1.0	-0.4	0.7	-0.5	-0.9	0.9
Run reversals in cocaine runway, males	3.5	3.5	4.8	-1.5	1.4	1.7	-2.1	-2.2	2.2
Latency to leave start box in cocaine runway	0.4	0.4	1.2	1.1	1.1	-0.5	-0.2	-0.2	0.2
Latency to leave start box in cocaine runway, F	0.7	0.8	2.2	1.5	1.4	-0.8	-0.1	0.0	0.0
Latency to leave start box in cocaine runway, M	0.4	0.4	1.1	-1.0	-0.2	0.7	-0.4	-0.4	0.4
Std. dev. time between licks in bursts	0.7	0.9	3.7	-0.7	-1.9	0.1	0.8	0.6	-0.6
Total sessions with >9 infusions	0.2	0.2	0.4	-0.6	-0.1	0.5	-0.4	-0.5	0.5
Short access day 1 total inactive lever presses	0.4	0.5	2.1	0.6	1.4	0.1	-0.6	-0.0	0.0
Short access day 10 total inactive lever presses	0.0	0.1	0.2	-0.1	0.5	0.3	-0.3	-0.1	0.1
Short access day 1 total infusions	0.0	0.0	0.1	0.2	0.1	-0.1	0.1	0.1	-0.1
Short access day 10 total infusions	0.6	0.7	1.7	1.3	0.4	-0.9	0.6	0.8	-0.8
Short access total infusions	0.0	0.0	0.0	-0.1	-0.2	-0.0	0.1	-0.0	0.0
Short access day 1 locomotion	0.9	1.2	1.7	-0.8	1.1	1.1	-1.3	-1.1	1.1
Short access day 10 total locomotion	0.1	0.2	0.8	0.3	0.9	0.1	-0.5	-0.2	0.2
Short access total locomotion	0.0	0.0	0.0	0.2	-0.2	-0.2	0.2	0.2	-0.2
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.4	-0.3	0.2	-0.1	-0.3	0.3
Compulsive drug intake	0.7	0.8	1.2	0.7	-0.9	-0.9	1.1	0.9	-0.9
One hour access (shock baseline)	0.5	0.8	1.4	-0.4	1.2	0.7	-1.1	-0.8	0.9
Social response proportion	0.2	0.3	0.5	-0.7	-0.5	0.5	-0.4	-0.5	0.5
Social responses	0.3	0.4	1.7	-0.8	-1.3	0.2	0.1	-0.3	0.2
Social time	0.2	0.2	0.3	-0.5	0.2	0.5	-0.6	-0.5	0.5
Soleus weight	0.8	2.3	9.7	0.4	3.1	0.8	-1.6	-0.6	0.6
Bone: stiffness	0.0	0.1	0.2	-0.4	-0.1	0.4	-0.2	-0.1	0.1
Tibialis anterior weight	1.3	4.5	15.7	2.7	4.0	-1.1	-0.1	1.2	-1.2
Time to tail flick, vehicle, before self-admin	0.6	0.7	2.3	1.1	1.5	-0.4	-0.4	-0.2	0.2
Time to tail flick, vehicle, after self-admin	0.4	0.5	1.5	1.2	0.9	-0.7	0.2	0.3	-0.3
Time to tail flick, test, before self-admin	2.7	2.7	8.4	2.9	1.8	-1.8	0.5	0.9	-0.8
Time to tail flick, test, after self-admin	0.8	0.9	1.9	1.4	1.1	-0.6	0.2	0.9	-0.9
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.3	0.1	-0.3	0.1	-0.0	0.0
Delta time to tail flick, test, before/after SA	0.8	0.8	2.3	-1.5	-0.4	1.2	-0.6	-0.6	0.6
Tibia length	0.1	0.1	0.3	-0.0	0.6	0.2	-0.5	-0.4	0.4
Ambulatory time before self-admin	0.0	0.1	0.1	0.4	0.3	-0.3	-0.0	-0.2	0.2
Ambulatory time after self-admin	0.2	0.3	0.9	0.4	0.9	-0.1	-0.5	-0.5	0.5
Bone: tissue strength	0.6	0.6	1.2	-1.1	-1.0	0.7	-0.3	-0.7	0.7
Total heroin consumption	0.1	0.1	0.3	-0.2	-0.5	-0.1	0.2	-0.0	0.0
Bone: trabecular number	0.2	0.3	1.4	-0.2	-1.2	-0.2	0.6	0.3	-0.3
Bone: trabecular spacing	0.4	0.5	1.9	0.8	1.4	-0.2	-0.2	0.4	-0.4
Bone: trabecular thickness	0.3	0.4	0.9	-0.9	-0.9	0.5	-0.2	-0.6	0.6
Bone: trabecular tissue density	0.8	1.1	1.5	1.0	-0.4	-1.1	1.2	1.2	-1.2
Water consumed over 24 hours	1.9	2.6	3.5	-1.5	0.9	1.8	-1.9	-1.7	1.7
Number of responses in last shaping day	1.0	1.1	2.8	-0.3	1.7	1.0	-1.3	-0.8	0.8