Hub : Genes

LOC108350462

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 PL gene expression LOC108350462 0.07 0.05 3.2e-07 0.05 0.06 0.06 0.06 3.9e-06 1.9e-07 1.8e-07 3.8e-07
2 NAcc gene expression LOC108350462 0.13 0.07 0.0e+00 0.15 0.15 0.14 0.15 5.1e-17 4.4e-17 2.7e-16 4.0e-17
3 Brain gene expression LOC108350462 0.11 0.08 1.8e-09 0.08 0.1 0.09 0.09 6.1e-08 2.8e-09 4.3e-09 6.1e-09
4 PL alternative polyA XR_005502458.1 0.04 0.03 3.8e-04 0.03 0.03 0.02 0.02 4.7e-04 4.1e-04 1.3e-03 1.0e-03
5 pVTA gene expression LOC108350462 0.17 0.1 1.6e-06 0.08 0.14 0.12 0.12 3.5e-04 1.0e-06 7.4e-06 6.9e-06
6 BLA alternative polyA XR_005502458.1 0.06 0.04 2.8e-03 0.01 0.01 0 0.01 9.9e-02 7.1e-02 2.1e-01 9.0e-02
7 Liver gene expression LOC108350462 0.02 0.02 7.0e-03 0.01 0.01 0.01 0.01 9.6e-03 1.5e-02 4.8e-02 2.3e-02
8 PL alternative polyA XR_005502459.1 0.03 0.03 2.4e-03 0.02 0.02 0.02 0.02 1.6e-03 2.7e-03 2.6e-03 2.0e-03
9 pVTA alternative polyA XR_005502460.1 0.06 0.05 4.0e-03 0.01 0.04 0.02 0.03 8.9e-02 7.4e-03 6.3e-02 3.0e-02
10 NAcc alternative polyA XR_005502458.1 0.04 0.03 1.6e-05 0.05 0.04 0.05 0.05 7.4e-07 7.4e-06 1.8e-06 2.4e-06
11 Liver alternative polyA XR_005502459.1 0.02 0.02 9.4e-04 0.02 0.02 0.02 0.02 1.8e-03 4.6e-03 3.7e-03 2.9e-03
12 PL alternative polyA XR_005502460.1 0.06 0.04 2.6e-08 0.07 0.07 0.06 0.06 6.3e-08 8.5e-08 1.2e-07 1.1e-07
13 BLA gene expression LOC108350462 0.13 0.09 3.7e-06 0.07 0.03 0.06 0.04 7.5e-05 6.5e-03 4.9e-04 4.9e-03
14 NAcc alternative polyA XR_005502460.1 0.04 0.03 1.6e-06 0.04 0.05 0.05 0.04 7.0e-06 2.1e-06 3.4e-06 1.2e-05
15 BLA alternative polyA XR_005502460.1 0.08 0.06 3.3e-04 0.07 0.03 0.05 0.05 1.2e-04 1.3e-02 1.0e-03 1.2e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Bone: apparent density0.71.22.7-1.41.21.4-1.61.4-1.1-0.70.71.10.70.8-0.9-0.70.9-1.1
Area under the delay curve0.60.61.41.2-1.0-0.80.8-0.70.70.8-0.8-0.7-0.7-0.60.50.2-0.60.8
BMI with tail1.03.34.9-1.01.81.7-1.51.7-1.8-2.22.21.81.91.9-1.9-1.91.9-1.9
BMI without tail3.36.98.8-2.12.62.6-2.32.4-2.7-2.62.62.73.02.7-2.6-2.62.8-3.0
Body weight5.824.529.0-4.04.94.9-4.64.8-5.0-5.45.45.05.15.0-5.1-5.05.0-5.0
Weight adjusted by age3.64.15.4-1.82.32.2-2.32.3-2.1-1.71.72.12.21.8-1.8-2.22.0-1.4
Bone surface0.91.53.0-1.71.51.5-1.61.4-1.3-0.90.91.21.11.0-1.0-0.91.1-1.1
Bone volume0.91.52.5-1.51.41.4-1.61.4-1.2-1.01.01.21.01.0-1.0-0.91.0-1.0
Breakpoint value in progressive ratio session2.83.04.0-1.51.41.6-1.31.5-1.7-2.02.01.71.81.9-1.9-1.91.8-1.9
Number of licking bursts0.50.62.11.4-0.8-0.91.0-0.80.70.3-0.3-0.7-0.4-0.80.80.6-0.50.6
Context. condit. distance diff. score0.20.20.7-0.80.60.6-0.80.6-0.3-0.40.40.30.10.2-0.2-0.10.1-0.2
Locomotion velocity, session 10.30.31.4-1.20.60.7-0.70.7-0.6-0.00.00.60.50.3-0.3-0.60.5-0.4
Locomotion distance, session 10.71.04.9-2.21.11.2-1.41.1-0.8-0.10.10.80.40.6-0.6-0.50.5-0.8
Locomotion velocity, session 20.10.10.5-0.6-0.2-0.0-0.0-0.10.20.7-0.7-0.1-0.4-0.00.00.2-0.20.0
Locomotion distance, session 22.13.05.9-2.41.82.1-2.32.0-1.7-1.01.01.71.31.6-1.6-1.41.4-1.8
Locomotion velocity, session 31.11.31.6-1.31.11.0-0.80.9-1.1-1.11.11.11.31.2-1.2-1.11.2-1.2
Locomotion distance, session 36.87.48.9-2.32.62.6-2.42.5-2.7-2.92.92.72.83.0-3.0-2.72.7-3.0
Stereotopy head waving bouts, day 31.01.12.2-0.4-0.6-0.60.4-0.60.91.4-1.4-1.0-1.2-1.41.41.0-1.21.5
Stereotopy head waving duration, day 30.80.91.6-0.1-0.7-0.70.7-0.70.91.1-1.1-0.9-1.0-1.31.30.8-1.01.3
Locomotion velocity, session 71.11.21.6-1.11.11.1-1.11.1-1.1-1.31.31.10.81.1-1.1-1.31.0-1.0
Locomotion distance, session 71.11.42.9-1.51.01.4-1.71.4-1.2-0.70.71.20.81.1-1.1-1.11.0-1.3
Stereotopy head waving bouts, day 70.40.40.7-0.80.70.4-0.20.4-0.6-0.80.80.60.70.7-0.7-0.80.7-0.4
Stereotopy head waving duration, day 70.10.10.4-0.30.30.00.2-0.0-0.2-0.60.60.20.40.3-0.3-0.40.3-0.1
Locomotion velocity, session 80.80.93.0-1.71.21.1-1.21.0-0.8-1.11.10.80.60.6-0.6-0.50.5-0.6
Locomotion distance, session 83.34.810.3-3.22.52.6-3.02.5-2.1-1.81.82.11.61.9-1.9-1.61.6-1.9
Degree of sensitization distance1.71.82.70.8-1.4-1.00.6-0.91.31.6-1.6-1.3-1.6-1.51.51.2-1.41.5
Degree of sensitization stereotypy1.82.02.9-0.91.31.1-0.71.0-1.4-1.71.71.41.71.6-1.6-1.71.5-1.4
Conditioned locomotion4.04.78.6-2.92.62.4-2.42.4-2.2-1.61.62.22.22.0-2.0-2.02.0-1.6
Cocaine response after cond. corrected0.10.10.2-0.2-0.2-0.1-0.0-0.10.30.3-0.3-0.3-0.5-0.30.30.4-0.40.3
Cocaine response after cond. not corrected0.10.10.40.0-0.4-0.30.1-0.30.40.5-0.5-0.4-0.6-0.40.30.4-0.40.3
Cocaine response before conditioning0.10.10.30.5-0.5-0.40.3-0.30.30.4-0.4-0.3-0.3-0.10.10.1-0.20.1
Saline control response6.18.010.7-2.63.22.9-2.72.9-2.9-2.92.92.93.32.5-2.5-2.82.8-2.5
Bone: connectivity density0.40.61.6-1.30.91.0-1.21.0-0.8-0.30.30.80.40.5-0.5-0.40.6-0.8
Bone: cortical apparent density0.50.71.5-0.10.50.5-0.40.6-0.8-0.60.60.81.01.2-1.2-1.21.0-1.1
Bone: cortical area3.34.95.4-1.62.32.3-2.22.3-2.3-2.32.32.32.32.3-2.3-2.02.2-2.2
Bone: cortical porosity0.20.21.01.0-0.2-0.50.9-0.50.1-0.50.5-0.10.40.1-0.1-0.20.20.1
Bone: cortical porosity0.30.30.90.70.2-0.10.5-0.1-0.3-0.90.90.30.80.6-0.6-0.60.6-0.4
Bone: cortical thickness1.42.32.9-0.81.51.5-1.51.5-1.5-1.51.51.61.61.7-1.7-1.41.6-1.5
Bone: cortical thickness0.30.30.5-0.10.50.5-0.40.5-0.6-0.60.60.60.60.7-0.7-0.60.6-0.7
Bone: cortical tissue density0.40.51.2-0.00.40.4-0.30.5-0.7-0.50.50.70.81.1-1.1-1.10.9-0.9
Condit. Reinf. active minus inactive responses0.91.01.8-0.20.60.8-0.80.9-1.0-1.21.21.00.81.3-1.3-1.11.1-1.2
Condit. Reinf. active-inactive response ratio1.11.11.7-0.60.91.1-1.11.1-1.1-1.31.31.10.81.1-1.1-1.01.0-1.2
Condit. Reinf. active responses0.50.61.3-0.30.50.6-0.50.6-0.7-0.90.90.70.81.1-1.1-1.00.8-0.8
Condit. Reinf. inactive responses0.00.00.1-0.2-0.00.0-0.00.00.00.3-0.3-0.00.10.0-0.0-0.1-0.00.1
Incentive salience index mean0.40.50.9-0.20.60.6-0.60.7-0.7-0.80.80.70.70.9-0.9-0.90.7-0.7
Condit. Reinf. lever presses0.00.00.1-0.10.20.1-0.10.2-0.2-0.20.20.10.30.3-0.3-0.40.2-0.0
Condit. Reinf. active minus inactive responses3.13.95.6-2.12.02.2-2.42.2-2.1-1.41.42.11.52.0-2.0-1.91.9-2.0
Condit. Reinf. active-inactive response ratio2.83.03.8-1.71.71.9-1.91.9-1.8-1.51.51.81.41.7-1.8-1.71.7-1.7
Condit. Reinf. active responses4.96.88.9-2.92.72.9-3.02.8-2.7-1.91.92.72.22.6-2.6-2.62.5-2.7
Condit. Reinf. inactive responses1.11.33.1-1.71.31.3-1.41.2-1.2-0.70.71.11.01.0-1.0-1.11.0-1.1
Condit. Reinf. lever presses1.52.12.6-1.31.41.4-1.31.4-1.5-1.21.21.51.51.6-1.6-1.61.5-1.5
Condit. Reinf. lever reinforcers received3.85.37.4-2.72.52.6-2.72.6-2.4-1.61.62.41.92.3-2.3-2.32.2-2.3
Conditioned reinforcement - actives0.00.00.10.10.10.1-0.20.2-0.10.1-0.10.10.2-0.10.1-0.10.1-0.1
Conditioned reinforcement - inactives0.91.02.9-1.21.31.3-1.71.4-1.0-0.30.31.00.30.8-0.8-0.70.7-0.7
Conditioned locomotion0.10.20.50.7-0.2-0.30.2-0.20.3-0.00.0-0.30.1-0.70.70.4-0.40.6
Patch foraging indifference point 0 sec0.30.52.9-1.71.20.9-1.00.8-0.5-0.10.10.50.20.1-0.1-0.40.3-0.1
Patch foraging indifference point AUC0.50.61.0-0.60.70.8-0.70.8-0.8-0.80.80.80.80.8-0.8-0.70.8-1.0
Delay disc. indifference point, 0s delay3.74.06.92.6-2.4-2.12.2-2.12.01.3-1.3-2.0-1.7-2.12.11.7-1.92.1
Delay disc. indifference point, 16s delay0.90.91.71.1-1.1-1.01.0-0.90.91.3-1.3-0.9-1.0-0.80.70.6-0.80.8
Delay disc. indifference point, 2s delay0.10.10.80.9-0.3-0.30.4-0.30.30.1-0.1-0.3-0.3-0.30.20.0-0.20.5
Delay disc. indifference point, 24s delay2.62.64.21.6-1.8-1.61.4-1.41.62.0-2.0-1.6-1.7-1.31.11.4-1.51.6
Delay disc. indifference point, 4s delay0.10.10.30.5-0.3-0.30.4-0.20.1-0.20.2-0.10.0-0.1-0.0-0.40.10.2
Delay disc. indifference point, 8s delay0.70.72.01.4-1.0-1.01.0-0.80.70.9-0.9-0.7-0.6-0.60.50.3-0.50.8
Indifference point function ln k0.10.10.5-0.40.40.6-0.70.6-0.4-0.10.10.40.10.2-0.2-0.20.2-0.1
Indifference point function log k0.10.10.5-0.40.40.6-0.70.6-0.4-0.10.10.40.10.2-0.2-0.20.2-0.1
Patch foraging total patch changes 0 sec0.30.53.0-1.71.20.9-1.10.9-0.6-0.20.20.50.2-0.00.0-0.40.3-0.1
Patch foraging total patch changes 12 sec0.30.41.1-1.01.00.7-0.60.6-0.7-0.60.60.60.70.3-0.3-0.60.6-0.6
Patch foraging total patch changes 18 sec0.50.61.2-0.0-0.5-0.60.4-0.60.80.8-0.8-0.9-0.9-1.01.00.8-1.01.1
Patch foraging total patch changes 24 sec1.21.52.90.5-0.8-0.90.6-0.81.21.2-1.2-1.2-1.3-1.71.71.3-1.41.5
Patch foraging total patch changes 6 sec0.91.34.2-2.11.71.4-1.51.2-1.0-1.01.01.00.90.5-0.5-0.70.8-0.9
Patch foraging time to switch 0 sec2.53.96.52.4-2.2-2.32.5-2.42.11.6-1.6-2.0-1.6-1.71.71.7-1.81.6
Patch foraging water rate 0 sec5.18.215.5-3.93.43.3-3.43.2-2.9-2.52.52.92.32.4-2.4-2.52.5-2.3
Patch foraging water rate 12 sec0.30.41.2-1.10.60.8-1.00.8-0.6-0.40.40.6-0.10.7-0.7-0.50.4-0.5
Patch foraging water rate 18 sec0.50.71.1-0.80.90.9-0.90.8-0.8-1.01.00.80.70.6-0.6-0.50.8-0.9
Patch foraging water rate 24 sec0.40.60.9-0.60.70.7-0.70.8-0.8-0.80.80.80.80.9-0.9-0.90.9-0.7
Patch foraging water rate 6 sec2.13.03.6-1.61.71.8-1.81.8-1.8-1.91.91.81.71.8-1.8-1.81.7-1.4
Seeking ratio, delayed vs. immediate footshock0.10.20.40.3-0.5-0.40.3-0.40.40.5-0.5-0.4-0.6-0.40.50.3-0.40.1
Distance traveled before self-admin5.15.57.4-2.52.72.5-2.52.5-2.3-2.72.72.32.41.9-1.9-2.12.1-1.8
Distance traveled after self-admin3.23.65.7-2.32.01.9-1.71.8-1.8-2.42.41.82.21.4-1.4-1.71.7-1.6
Extensor digitorum longus weight0.10.41.1-0.50.30.5-0.30.3-0.5-1.01.00.50.50.8-0.8-0.40.5-0.5
Bone: elastic displacement0.10.10.60.8-0.5-0.30.5-0.40.10.0-0.0-0.1-0.00.3-0.3-0.10.1-0.3
Bone: elastic work0.10.10.40.6-0.2-0.10.2-0.1-0.1-0.50.50.10.20.4-0.4-0.20.2-0.3
Bone: endosteal estimation0.51.11.8-1.31.11.0-0.91.0-1.0-1.31.30.91.10.9-0.9-0.90.9-0.7
Bone: endosteal perimeter2.24.65.5-2.12.32.2-2.22.2-2.2-2.32.32.22.22.0-2.0-2.02.0-2.0
Epididymis fat weight1.22.83.5-1.81.81.6-1.41.6-1.7-1.91.91.71.81.7-1.7-1.51.7-1.6
Delta time in closed arm before/after self-admin0.20.20.30.3-0.5-0.50.5-0.50.50.5-0.5-0.5-0.6-0.30.30.4-0.40.4
Delta time in open arm before/after self-admin1.81.84.6-2.11.41.5-1.61.3-1.1-1.61.61.10.91.0-1.0-0.90.8-1.0
Diff in mean of infusions in LGA sessions0.10.10.40.6-0.5-0.30.5-0.50.20.1-0.1-0.1-0.20.0-0.00.2-0.1-0.4
Delay discount exponential model param0.50.51.3-1.20.90.8-0.80.7-0.6-0.80.80.70.60.6-0.4-0.20.5-0.8
Extinction: sum of active levers before priming0.80.81.2-0.80.70.7-0.60.7-0.8-1.11.10.81.00.8-0.8-1.00.9-1.0
Active lever presses in extinction session 60.30.30.70.6-0.4-0.30.3-0.30.40.3-0.3-0.4-0.4-0.80.80.7-0.50.5
Bone: final force3.25.26.3-1.92.42.3-2.32.4-2.4-2.12.12.42.52.4-2.4-2.22.3-2.2
Bone: final moment2.54.14.9-1.72.12.0-2.02.1-2.1-2.02.02.12.22.1-2.1-1.92.0-1.9
Food consumed during 24 hour testing period0.91.01.60.6-0.7-0.90.8-0.91.01.0-1.0-1.0-0.9-1.31.31.2-1.11.3
Glucose0.40.61.4-0.90.90.8-0.70.7-0.7-1.21.20.70.70.4-0.4-0.30.5-0.4
Heart weight4.05.78.9-3.02.72.7-2.92.7-2.4-1.91.92.41.92.3-2.2-2.22.1-2.2
Delay discount hyperbolic model param0.40.51.3-1.10.80.8-0.80.6-0.6-0.70.70.60.60.6-0.4-0.20.5-0.8
Intermittent access intake day 1-15 change0.60.61.2-0.50.80.9-1.00.9-0.8-1.11.10.80.70.6-0.6-0.50.7-0.7
Intermittent access intake escalation0.20.20.6-0.10.50.6-0.80.6-0.5-0.50.50.50.30.3-0.3-0.20.4-0.5
Intermittent access intake escalation 20.10.10.30.5-0.3-0.1-0.1-0.10.20.0-0.0-0.2-0.3-0.30.30.5-0.30.0
Intermitt. access day 1 inactive lever presses0.10.10.70.30.10.3-0.70.30.00.4-0.4-0.0-0.9-0.40.40.3-0.20.0
Intermitt. access day 15 inactive lever presses0.10.10.3-0.40.40.3-0.60.4-0.00.0-0.0-0.0-0.0-0.20.20.2-0.20.5
Intermitt. access escalation Index0.10.10.80.9-0.4-0.40.6-0.50.2-0.10.1-0.2-0.2-0.20.20.2-0.10.1
Intermittent access day 1 total infusions0.20.30.90.9-0.7-0.60.7-0.60.50.2-0.2-0.5-0.0-0.50.50.4-0.40.6
Intermittent access day 15 total infusions0.00.00.20.20.10.3-0.40.3-0.2-0.30.30.20.2-0.00.00.00.1-0.2
Intermittent access terminal intake (last 3 days)0.00.00.2-0.10.10.3-0.50.3-0.1-0.20.20.10.2-0.10.10.1-0.0-0.0
Intermittent access total infusions0.00.00.10.3-0.2-0.0-0.1-0.00.20.0-0.0-0.20.1-0.30.30.3-0.20.3
Intermittent access day 1 locomotion0.10.10.30.6-0.3-0.30.2-0.20.30.6-0.6-0.3-0.2-0.50.50.3-0.30.4
Intermittent access day 15 total locomotion0.10.10.7-0.20.30.4-0.80.5-0.10.2-0.20.1-0.1-0.40.40.2-0.20.1
Intermittent access total locomotion0.10.10.30.4-0.2-0.0-0.20.00.20.2-0.2-0.2-0.1-0.60.60.4-0.30.4
Intermittent access standard deviation0.10.10.3-0.10.10.2-0.20.3-0.2-0.30.30.20.50.3-0.3-0.20.3-0.2
Left kidney weight0.92.63.8-1.81.81.8-1.91.9-1.6-1.81.81.61.71.1-1.2-1.41.4-1.1
Right kidney weight1.02.74.6-2.21.91.9-2.01.9-1.7-1.51.51.61.71.2-1.2-1.31.4-1.3
Cocaine induced anxiety5.15.98.11.6-2.0-2.11.9-2.12.42.6-2.6-2.4-2.8-2.72.72.6-2.62.9
Post-drug Anxiety1.51.72.80.7-1.0-1.11.1-1.21.31.6-1.6-1.3-1.7-1.31.31.3-1.41.5
Baseline Anxiety0.80.81.4-0.80.70.8-0.70.8-0.9-0.90.90.91.01.2-1.2-1.00.9-1.0
Tail length4.513.817.9-3.13.53.5-3.13.4-3.8-3.83.83.84.24.0-3.9-3.73.9-4.0
Length with tail4.717.118.5-4.04.24.1-3.94.1-4.2-4.34.34.14.34.1-4.2-4.14.1-3.9
Length without tail1.53.34.6-1.81.91.8-1.81.9-1.7-2.12.11.71.51.8-1.8-1.91.6-1.3
Times rat made contact with spout0.10.10.3-0.60.30.1-0.0-0.00.10.1-0.1-0.1-0.1-0.30.30.3-0.20.3
Lifetime Intake0.10.10.30.00.10.3-0.30.3-0.2-0.60.60.20.60.1-0.1-0.10.20.0
Liver weight, left0.10.10.3-0.40.00.2-0.30.20.2-0.10.1-0.2-0.1-0.50.50.4-0.40.6
Liver weight, right0.10.10.91.0-0.3-0.20.3-0.10.1-0.30.3-0.10.3-0.20.20.00.00.2
Locomotor activity0.20.30.7-0.30.50.6-0.70.7-0.7-0.00.00.70.30.5-0.5-0.60.7-0.8
Locomotor testing distance0.00.10.4-0.00.0-0.0-0.10.00.10.6-0.6-0.1-0.4-0.30.30.3-0.20.0
Locomotor testing rearing0.50.82.2-1.51.11.0-1.31.1-0.90.0-0.00.80.50.7-0.7-0.80.7-0.7
Locomotion in novel chamber0.10.10.20.2-0.4-0.20.1-0.10.20.5-0.5-0.2-0.5-0.00.10.2-0.20.2
Locomotion in novel chamber post-restriction1.31.52.6-1.21.11.3-1.21.2-1.3-1.01.01.31.11.4-1.3-1.21.3-1.6
Fecal boli incidents, locomotor time 10.00.00.2-0.10.10.10.10.0-0.2-0.40.40.20.2-0.00.1-0.20.3-0.3
Change in fecal boli incidents, locomotor task0.10.10.3-0.5-0.1-0.20.1-0.10.20.4-0.4-0.2-0.4-0.10.1-0.1-0.30.3
Time >=10cm from walls, locomotor time 10.10.10.10.20.30.1-0.10.1-0.2-0.30.30.20.20.0-0.0-0.20.3-0.3
Bouts of movement, locomotor time 12.62.94.12.0-2.0-1.91.9-1.81.71.5-1.5-1.7-1.3-1.61.61.6-1.61.6
Total resting periods, locomotor time 12.02.23.31.8-1.8-1.71.7-1.61.51.4-1.4-1.5-1.2-1.31.31.3-1.31.3
Rest time, locomotor task time 10.20.20.40.4-0.6-0.60.6-0.60.50.6-0.6-0.5-0.4-0.40.40.3-0.40.3
Distance moved, locomotor task time 10.10.10.3-0.50.40.3-0.20.2-0.2-0.40.40.20.10.1-0.2-0.10.1-0.1
Vertical activity count, locomotor time 10.20.21.3-1.10.80.5-0.40.4-0.3-0.50.50.30.30.2-0.2-0.20.2-0.1
Time >=10cm from walls, locomotor time 20.00.00.10.2-0.1-0.20.2-0.20.1-0.20.2-0.10.1-0.20.2-0.1-0.10.1
Bouts of movement, locomotor time 20.91.02.61.6-1.1-1.31.4-1.21.00.3-0.3-1.0-0.4-0.70.70.8-0.80.9
Total resting periods, locomotor time 20.90.93.31.8-1.2-1.21.4-1.21.00.3-0.3-0.9-0.4-0.50.60.7-0.70.7
Rest time, locomotor task time 20.40.51.91.4-0.8-0.70.7-0.60.50.8-0.8-0.5-0.6-0.40.50.5-0.30.2
Distance moved, locomotor task time 20.10.10.9-1.00.30.3-0.30.10.00.0-0.0-0.0-0.1-0.20.20.2-0.30.3
Vertical activity count, locomotor time 20.40.42.9-1.71.00.8-0.70.6-0.4-0.30.30.40.40.2-0.2-0.10.1-0.1
Light reinforcement 10.91.72.9-1.31.21.2-1.11.2-1.3-0.80.81.31.31.5-1.5-1.71.4-1.4
Light reinforcement 20.60.91.5-0.80.80.9-0.80.9-0.9-0.70.70.90.91.2-1.2-1.21.0-0.9
Bone: marrow area0.51.01.7-1.31.11.0-0.90.9-0.9-1.31.30.91.00.9-0.9-0.80.8-0.7
Bone: maximum diameter4.48.19.2-2.43.03.0-2.93.0-2.9-2.92.92.93.02.8-2.8-2.62.8-2.7
Bone: maximum force0.50.91.4-0.91.21.0-1.01.1-1.0-0.80.81.01.20.9-0.9-0.70.9-0.8
Bone: maximum moment0.20.40.6-0.60.80.6-0.70.7-0.6-0.60.60.60.80.6-0.6-0.30.5-0.4
Mean time between licks in bursts0.10.20.80.4-0.1-0.30.4-0.30.2-0.90.9-0.2-0.0-0.20.20.2-0.20.4
Mean num. licks in bursts0.50.63.3-1.81.00.9-1.10.8-0.6-0.10.10.60.30.5-0.5-0.40.3-0.3
Cd content in liver0.10.10.20.3-0.20.0-0.30.10.00.4-0.4-0.0-0.40.2-0.20.1-0.0-0.4
Co content in liver0.91.11.4-0.91.11.1-1.21.2-1.1-0.90.91.10.91.0-1.0-1.11.0-1.0
Cu content in liver2.32.84.5-2.11.71.7-1.61.6-1.7-1.41.41.71.61.7-1.7-1.71.6-1.6
Fe content in liver0.00.00.2-0.50.30.2-0.30.2-0.1-0.20.20.10.0-0.10.10.1-0.0-0.0
K content in liver0.30.30.4-0.40.40.6-0.60.6-0.6-0.30.30.60.50.6-0.6-0.50.5-0.6
Mg content in liver1.81.82.2-1.31.41.5-1.51.4-1.4-1.21.21.41.31.4-1.4-1.31.3-1.3
Mn content in liver1.92.12.8-1.41.41.5-1.51.5-1.5-0.90.91.51.51.5-1.5-1.61.5-1.7
Na content in liver0.10.10.20.2-0.3-0.20.2-0.20.30.4-0.4-0.3-0.2-0.30.30.4-0.30.3
Rb content in liver5.06.28.9-3.02.82.8-2.72.5-2.4-2.72.72.42.12.3-2.3-2.02.1-2.2
Se content in liver1.11.42.3-1.21.21.4-1.51.4-1.2-0.60.61.21.01.1-1.1-1.01.1-1.5
Sr content in liver0.40.30.6-0.20.60.5-0.40.5-0.6-0.80.80.60.70.5-0.5-0.70.6-0.5
Zn content in liver0.20.30.6-0.40.60.7-0.80.7-0.6-0.20.20.60.40.4-0.4-0.40.5-0.4
Bone: minimum diameter1.62.94.3-1.51.81.7-1.61.7-1.7-2.12.11.71.81.7-1.7-1.51.6-1.5
Time in familiar zone, hab. session 11.11.01.70.8-1.1-1.01.0-1.11.10.8-0.8-1.1-1.3-1.01.01.1-1.10.9
Time in novel zone, hab. session 10.50.50.9-0.90.80.8-1.00.9-0.8-0.30.30.70.70.7-0.7-0.80.7-0.6
Total zone transitions, hab. session 10.30.51.3-0.90.60.9-1.10.9-0.60.1-0.10.60.30.6-0.6-0.50.5-0.8
Total locomotion distance, hab. session 10.30.41.5-1.20.50.8-1.20.9-0.50.4-0.40.50.00.4-0.4-0.50.3-0.5
Locomotion velocity, hab. session 10.30.51.6-1.20.60.9-1.31.0-0.60.4-0.40.60.20.5-0.5-0.50.4-0.6
Time in familiar zone, hab. session 21.31.41.81.0-1.2-1.11.0-1.11.21.2-1.2-1.2-1.3-1.21.21.2-1.31.1
Time in novel zone, hab. session 21.41.41.8-1.01.21.1-1.01.1-1.2-1.21.21.21.31.2-1.2-1.21.3-1.2
Total zone transitions, hab. session 22.43.14.0-1.71.71.9-1.91.8-1.8-1.31.31.91.81.8-1.8-1.81.8-2.0
Total locomotion distance, hab. session 21.21.63.9-1.91.31.6-2.01.7-1.3-0.20.21.20.91.0-1.0-1.01.0-1.1
Locomotion velocity, hab. session 20.71.03.0-1.71.01.3-1.71.4-0.90.2-0.20.90.50.7-0.7-0.70.6-0.8
Novel to familiar place preference ratio0.20.20.60.2-0.2-0.20.2-0.30.40.1-0.1-0.4-0.4-0.80.80.7-0.50.6
Novelty place preference0.40.40.90.3-0.4-0.50.4-0.50.60.3-0.3-0.6-0.6-1.01.00.9-0.70.8
Time in novel zone, NPP test0.20.20.60.2-0.3-0.30.3-0.40.40.1-0.1-0.5-0.4-0.80.80.7-0.50.6
Total zone transitions, NPP test0.20.30.5-0.50.20.5-0.60.5-0.50.3-0.30.50.40.6-0.6-0.60.5-0.7
Total locomotion distance, NPP test0.60.82.8-1.70.81.2-1.61.2-0.80.3-0.30.80.40.6-0.6-0.70.5-0.7
Locomotion velocity, NPP test0.30.51.9-1.40.50.8-1.20.9-0.50.7-0.70.4-0.00.3-0.3-0.40.2-0.4
Intraocular pressure0.00.00.10.20.0-0.00.1-0.0-0.1-0.10.10.10.10.2-0.1-0.30.2-0.3
Delta distance traveled before/after self-admin0.20.30.9-0.90.30.30.00.1-0.4-0.50.50.40.70.6-0.6-0.60.5-0.6
Delta ambulatory time before/after self-admin0.70.82.00.4-1.1-1.11.4-1.31.00.7-0.7-0.9-0.4-0.70.70.7-0.80.6
Parametrial fat weight0.10.30.50.4-0.5-0.60.7-0.70.60.5-0.5-0.6-0.6-0.50.50.6-0.50.4
Pavlov. Cond. lever latency0.20.20.6-0.20.40.3-0.10.3-0.5-0.30.30.50.40.6-0.6-0.70.6-0.7
Pavlov. Cond. magazine entry latency0.10.20.5-0.10.20.5-0.70.6-0.4-0.20.20.40.30.6-0.6-0.30.4-0.5
Pavlov. Cond. change in total contacts0.10.10.1-0.20.10.3-0.40.3-0.2-0.20.20.20.20.3-0.3-0.10.2-0.2
Pavlov. Cond. index score0.00.00.10.1-0.10.1-0.20.1-0.0-0.10.1-0.00.00.1-0.10.1-0.00.0
Pavlov. Cond. latency score0.00.10.20.3-0.3-0.1-0.20.00.20.2-0.2-0.2-0.2-0.20.20.4-0.30.3
Pavlov. Cond. lever contacts0.00.00.2-0.30.20.3-0.40.3-0.2-0.20.20.20.30.1-0.1-0.00.10.0
Pavlov. Cond. magazine entry number0.50.60.90.1-0.5-0.60.5-0.60.80.9-0.9-0.8-0.9-1.01.00.8-0.90.9
Pavlov. Cond. intertrial magazine entries0.30.30.7-0.80.50.6-0.60.5-0.5-0.60.60.50.30.6-0.6-0.50.4-0.6
Pavlov. Cond. lever-magazine prob. diff.0.00.00.00.2-0.20.0-0.10.10.0-0.10.1-0.0-0.00.1-0.10.1-0.10.1
Pavlov. Cond. response bias0.40.50.7-0.40.50.6-0.60.7-0.7-0.80.80.70.80.7-0.7-0.60.7-0.6
Pavlov. Cond. lever latency3.75.06.31.8-2.2-2.12.0-2.22.32.1-2.1-2.3-2.5-2.42.42.5-2.42.1
Pavlov. Cond. magazine entry latency0.20.21.0-1.00.70.4-0.40.4-0.3-0.40.40.30.30.3-0.3-0.20.2-0.0
Pavlov. Cond. change in total contacts3.64.96.3-2.02.32.0-1.82.1-2.2-2.22.22.22.32.5-2.5-2.52.3-1.9
Pavlov. Cond. index score3.24.04.8-1.92.11.9-1.71.9-2.0-2.12.12.02.12.2-2.2-2.12.0-1.7
Pavlov. Cond. latency score2.43.03.6-1.71.91.7-1.51.7-1.7-1.81.81.71.81.8-1.8-1.81.7-1.4
Pavlov. Cond. lever contacts3.85.26.5-2.02.32.2-2.12.3-2.3-2.32.32.32.62.4-2.4-2.42.3-2.0
Pavlov. Cond. magazine entry number0.70.81.11.0-1.0-0.80.7-0.80.81.0-1.0-0.8-0.9-1.11.10.9-0.80.7
Pavlov. Cond. intertrial magazine entries0.91.22.10.9-1.1-0.90.8-0.91.01.5-1.5-1.1-1.2-1.01.01.1-1.11.0
Pavlov. Cond. lever-magazine prob. diff.2.83.64.2-1.82.01.8-1.61.8-1.9-2.02.01.92.02.0-2.0-2.01.9-1.5
Pavlov. Cond. response bias4.35.86.6-2.32.52.3-2.22.4-2.4-2.52.52.42.62.6-2.6-2.52.4-2.1
Time in closed arm before self-admin0.30.30.60.3-0.6-0.60.7-0.70.60.2-0.2-0.6-0.5-0.80.80.5-0.60.5
Time in closed arm after self-admin0.80.81.70.8-1.0-1.11.3-1.21.00.5-0.5-0.9-0.9-0.80.80.7-0.80.7
Time in open arm before self-admin0.60.71.71.1-0.6-0.70.7-0.60.61.3-1.3-0.6-0.5-0.80.80.8-0.50.5
Time in open arm after self-admin0.30.31.2-1.10.80.8-1.00.8-0.5-0.30.30.50.50.1-0.1-0.20.3-0.2
Bone: periosteal estimation2.24.65.9-1.92.32.1-2.02.1-2.2-2.42.42.12.32.1-2.1-2.02.1-1.9
Bone: periosteal perimeter3.55.88.2-2.22.62.5-2.42.4-2.4-2.92.92.42.42.2-2.2-2.12.2-2.1
Bone: post-yield work0.81.12.10.8-0.7-1.11.1-1.01.10.9-0.9-1.1-0.8-1.21.21.1-1.11.5
Progressive ratio test 1 active lever presses2.12.22.9-0.81.31.5-1.51.5-1.6-1.71.71.61.71.4-1.4-1.51.6-1.5
Progressive ratio test 1 breakpoint2.83.03.8-1.11.61.7-1.71.7-1.8-2.02.01.81.91.6-1.6-1.71.8-1.8
Progressive ratio test 1 inactive lever presses0.50.51.4-0.50.80.9-1.21.0-0.7-0.50.50.70.40.5-0.5-0.50.6-0.7
Progressive ratio test 2 active lever presses0.20.20.5-0.50.50.6-0.70.6-0.4-0.60.60.40.60.1-0.1-0.20.3-0.3
Progressive ratio test 2 breakpoint0.10.20.3-0.30.40.5-0.50.4-0.4-0.50.50.40.50.1-0.1-0.10.3-0.4
Progressive ratio test 2 inactive lever presses0.30.41.4-0.80.80.9-1.20.9-0.6-0.20.20.60.20.3-0.3-0.30.3-0.4
Incentive Sensitization - Responses0.20.20.7-0.20.30.3-0.20.2-0.3-0.80.80.30.60.2-0.2-0.20.3-0.4
Incentive Sensitization - Breakpoint0.10.10.4-0.10.20.1-0.10.0-0.1-0.70.70.10.4-0.10.10.10.0-0.2
Sum of active levers in priming session hrs 5-61.31.32.4-1.51.21.3-1.21.2-1.2-0.80.81.20.81.1-1.1-1.21.1-1.1
Progressive ratio3.64.27.21.0-2.0-2.32.4-2.22.22.1-2.1-2.2-1.7-1.91.81.6-2.02.7
Food seeking constrained by brief footshock0.60.73.0-1.71.11.1-1.31.1-0.7-0.40.40.70.30.3-0.2-0.50.4-0.2
Seeking ratio, punishment vs. effort3.84.67.9-1.62.32.6-2.82.5-2.3-2.12.12.31.71.8-1.6-1.62.0-2.5
Retroperitoneal fat weight0.10.21.01.0-0.4-0.40.3-0.30.30.1-0.1-0.4-0.2-0.40.40.5-0.40.4
Reaction time number correct0.40.52.6-1.61.00.8-0.80.8-0.7-0.40.40.60.40.5-0.5-0.60.5-0.1
Reaction time mean minus median0.70.91.40.5-0.8-0.90.9-0.91.01.2-1.2-1.0-1.1-0.90.91.0-1.00.9
Reaction time mean minus median AUC0.30.40.90.1-0.5-0.60.5-0.60.71.0-1.0-0.7-0.9-0.50.50.6-0.70.6
Reaction time num false alarms2.12.94.3-1.71.91.9-2.12.0-1.8-1.41.41.71.61.5-1.5-1.71.6-1.5
Reaction time num false alarms AUC2.12.93.7-1.51.91.8-1.91.9-1.8-1.51.51.71.71.6-1.6-1.81.7-1.5
Reaction time trials correct on left0.40.52.6-1.61.00.8-0.80.8-0.7-0.40.40.60.40.5-0.5-0.60.5-0.1
Reaction time trials on left0.40.62.8-1.71.10.9-0.80.9-0.7-0.40.40.70.50.6-0.6-0.70.6-0.2
Reaction time mean0.00.00.40.6-0.3-0.20.1-0.10.1-0.00.0-0.1-0.0-0.20.20.1-0.0-0.1
Reaction time mean AUC0.00.00.30.6-0.3-0.20.1-0.10.10.0-0.0-0.1-0.1-0.20.20.1-0.1-0.1
Median of all reaction times0.00.10.20.40.00.1-0.20.2-0.2-0.40.40.20.30.0-0.1-0.10.3-0.3
Reaction time omissions0.81.11.9-1.21.11.2-1.41.2-1.1-0.40.41.10.71.1-1.1-1.00.9-1.3
Reaction time false alarm rate1.01.42.0-0.61.21.3-1.41.3-1.2-1.11.11.21.31.1-1.1-1.31.2-1.3
Reaction time premature initiation rate0.20.20.91.0-0.7-0.40.3-0.30.30.6-0.6-0.3-0.7-0.20.20.2-0.2-0.0
Reaction time premature initiations0.10.10.40.2-0.2-0.10.0-0.00.10.6-0.6-0.1-0.6-0.10.10.1-0.10.1
Std. dev. reaction times0.10.10.20.00.10.2-0.20.3-0.3-0.10.10.30.30.5-0.5-0.40.4-0.5
Reaction time trials completed0.40.62.8-1.71.10.9-0.80.9-0.7-0.40.40.70.50.6-0.6-0.70.6-0.2
Reaction time trials AUC0.50.73.1-1.81.20.9-0.80.9-0.8-0.50.50.70.50.6-0.6-0.70.6-0.2
Run reversals in cocaine runway, females0.10.10.4-0.40.40.5-0.60.4-0.20.1-0.10.2-0.20.4-0.2-0.00.1-0.0
Run reversals in cocaine runway, males1.61.62.8-1.01.21.5-1.71.4-1.3-1.11.11.30.81.1-1.1-1.11.2-1.6
Latency to leave start box in cocaine runway0.70.81.31.1-0.9-0.90.9-1.00.80.9-0.9-0.8-0.6-1.01.01.0-0.80.5
Latency to leave start box in cocaine runway, F1.51.72.51.3-1.3-1.31.3-1.41.31.2-1.2-1.2-0.9-1.61.61.5-1.20.8
Latency to leave start box in cocaine runway, M0.10.10.1-0.00.30.3-0.40.4-0.3-0.10.10.30.30.4-0.4-0.20.2-0.3
Std. dev. time between licks in bursts0.40.51.3-0.50.80.7-0.70.7-0.7-1.11.10.70.80.4-0.4-0.60.6-0.5
Total sessions with >9 infusions0.30.31.10.00.20.20.00.2-0.3-1.11.10.41.10.5-0.5-0.50.5-0.1
Short access day 1 total inactive lever presses0.70.81.91.4-1.0-0.80.6-0.60.81.1-1.1-0.8-1.1-0.70.70.7-0.70.7
Short access day 10 total inactive lever presses2.73.05.21.1-1.3-1.30.8-1.21.71.8-1.8-1.7-2.3-2.12.12.2-2.01.9
Short access day 1 total infusions0.10.10.30.3-0.2-0.10.2-0.10.1-0.50.5-0.10.2-0.10.10.1-0.10.3
Short access day 10 total infusions0.10.10.70.8-0.4-0.30.4-0.20.2-0.20.2-0.20.3-0.20.20.1-0.10.3
Short access total infusions0.20.21.10.10.10.2-0.10.2-0.3-1.01.00.30.90.2-0.2-0.30.3-0.1
Short access day 1 locomotion0.70.81.61.0-0.7-0.60.4-0.70.90.3-0.3-0.9-0.9-1.31.31.1-1.11.0
Short access day 10 total locomotion0.00.00.10.10.10.2-0.30.2-0.2-0.30.30.20.40.1-0.1-0.10.2-0.3
Short access total locomotion0.00.00.2-0.10.20.3-0.40.3-0.2-0.30.30.20.3-0.10.1-0.00.1-0.0
One hour access (0.3 mA shock)0.00.10.30.20.00.3-0.50.3-0.10.1-0.10.1-0.2-0.20.20.3-0.1-0.1
Compulsive drug intake4.24.27.42.7-2.1-2.01.8-1.91.92.4-2.4-1.9-2.2-1.91.91.9-1.81.7
One hour access (shock baseline)0.50.61.1-1.00.80.8-0.80.7-0.7-1.01.00.70.80.5-0.5-0.40.6-0.6
Social response proportion2.12.36.5-2.51.91.6-1.61.5-1.5-1.01.01.41.41.4-1.4-1.41.3-1.1
Social responses5.06.48.0-2.82.82.6-2.42.5-2.6-2.02.02.62.62.5-2.6-2.72.6-2.5
Social time0.40.51.0-0.50.60.7-0.70.7-0.8-0.50.50.80.90.8-0.8-1.00.8-0.7
Soleus weight0.10.20.7-0.90.40.5-0.60.5-0.4-0.40.40.30.20.4-0.4-0.30.2-0.3
Bone: stiffness1.62.53.2-1.41.71.7-1.71.8-1.7-1.41.41.61.81.5-1.6-1.41.6-1.4
Tibialis anterior weight1.03.44.4-1.41.61.9-1.81.8-1.9-1.91.91.91.72.1-2.1-1.81.9-2.1
Time to tail flick, vehicle, before self-admin1.51.62.40.7-1.2-1.10.8-1.01.31.2-1.2-1.3-1.3-1.51.51.4-1.51.6
Time to tail flick, vehicle, after self-admin0.00.00.10.0-0.4-0.30.4-0.30.2-0.10.1-0.2-0.1-0.20.20.1-0.10.3
Time to tail flick, test, before self-admin0.80.81.7-0.40.70.8-0.60.8-1.0-0.60.61.00.61.3-1.3-1.11.1-0.9
Time to tail flick, test, after self-admin1.81.93.20.9-1.3-1.21.0-1.11.41.4-1.4-1.4-1.8-1.41.41.5-1.51.7
Delta time to tail flick, vehicle, before/after SA2.72.73.5-1.91.81.6-1.31.5-1.7-1.51.51.71.61.7-1.7-1.61.8-1.6
Delta time to tail flick, test, before/after SA1.91.72.70.6-1.0-1.00.8-1.11.41.3-1.3-1.4-1.5-1.51.51.5-1.61.6
Tibia length4.412.318.1-2.73.23.1-2.62.9-3.4-4.34.33.43.83.8-3.8-3.73.6-3.7
Ambulatory time before self-admin3.83.95.5-2.32.31.9-1.82.0-1.9-2.42.41.92.11.7-1.7-1.91.8-1.5
Ambulatory time after self-admin3.84.27.7-2.82.11.9-1.51.6-1.8-2.62.61.92.41.6-1.6-1.91.8-1.8
Bone: tissue strength0.10.10.3-0.40.40.4-0.50.5-0.4-0.00.00.40.40.2-0.2-0.30.4-0.2
Total heroin consumption3.74.35.5-1.92.02.2-2.22.2-2.2-1.81.82.22.12.0-2.0-2.02.2-2.3
Bone: trabecular number0.91.52.6-1.21.21.4-1.61.5-1.3-0.80.81.31.01.2-1.2-1.11.1-1.3
Bone: trabecular spacing0.20.20.60.7-0.6-0.50.5-0.50.40.6-0.6-0.4-0.3-0.20.20.1-0.30.3
Bone: trabecular thickness0.60.71.1-0.80.90.9-1.00.9-0.8-1.01.00.80.60.7-0.8-0.40.7-0.8
Bone: trabecular tissue density1.42.02.8-1.51.51.6-1.71.6-1.5-1.01.01.51.41.5-1.5-1.31.4-1.3
Water consumed over 24 hours0.10.10.20.4-0.3-0.40.5-0.40.30.4-0.4-0.3-0.2-0.40.40.3-0.30.4
Number of responses in last shaping day0.10.10.30.1-0.4-0.30.3-0.30.30.2-0.2-0.4-0.5-0.30.30.1-0.40.4