Hub : Genes

LOC108350462

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression LOC108350462 0.16 0.08 3.0e-14 0.14 0.1 0.17 0.13 1.9e-11 8.1e-09 2.5e-13 1.1e-10
2 Brain gene expression LOC108350462 0.12 0.07 1.5e-11 0.1 0.11 0.11 0.11 4.9e-10 1.4e-10 1.4e-10 1.3e-10
3 BLA alternative polyA XR_005502459.2 0.05 0.04 9.6e-03 0 0.01 0 -0 3.2e-01 1.4e-01 1.6e-01 3.8e-01
4 PL gene expression LOC108350462 0.09 0.05 1.6e-12 0.12 0.12 0.12 0.12 2.2e-13 7.1e-13 3.9e-13 1.7e-13
5 NAcc gene expression LOC108350462 0.07 0.05 3.6e-13 0.08 0.09 0.08 0.08 6.1e-12 7.7e-13 3.0e-12 9.4e-12
6 IC gene expression LOC108350462 0.15 0.1 1.8e-05 0.06 0.04 0.09 -0 1.2e-03 7.7e-03 1.1e-04 3.9e-01
7 OFC isoform ratio XR_005502459.2 0.25 0.19 2.1e-03 0.15 0.11 0.17 0.14 2.3e-04 1.5e-03 8.2e-05 2.9e-04
8 Liver gene expression LOC108350462 0.09 0.06 1.1e-10 0.07 0.07 0.07 0.07 2.0e-08 5.5e-08 1.8e-08 1.5e-08
9 Liver alternative polyA XR_005502459.2 0.03 0.02 3.9e-04 0.02 0.01 0.01 0.01 2.7e-03 1.4e-02 8.6e-03 7.9e-03
10 PL isoform ratio XR_005502459.2 0.03 0.03 4.7e-03 0.03 0.02 0.02 0.02 5.9e-04 6.1e-03 1.2e-03 2.4e-03
11 BLA gene expression LOC108350462 0.15 0.1 7.3e-08 0.1 0.09 0.09 0.07 7.4e-06 2.7e-05 1.4e-05 1.7e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.81.42.81.31.1-1.30.91.11.2-1.60.7-0.7-1.71.0
Area under the delay curve0.50.60.9-1.0-0.70.8-0.7-0.9-0.60.5-0.60.50.9-1.0
BMI with tail0.10.30.60.50.5-0.50.50.70.5-0.10.6-0.60.20.8
BMI without tail1.85.67.62.22.2-2.22.32.52.4-2.82.7-2.7-0.82.7
Body weight3.012.915.63.53.6-3.53.63.83.7-3.93.9-3.8-2.23.7
Weight adjusted by age2.84.35.42.02.1-2.12.32.02.3-2.12.3-1.8-2.11.7
Bone surface1.12.04.81.41.4-1.41.21.31.4-2.21.0-1.0-1.91.1
Bone volume1.01.93.81.41.3-1.41.21.21.4-1.91.0-1.0-1.81.0
Breakpoint value in progressive ratio session1.92.22.71.51.4-1.51.61.61.5-1.21.6-1.5-1.21.7
Number of licking bursts0.30.50.9-0.9-0.90.8-0.9-0.7-0.50.0-0.30.71.0-0.5
Context. condit. distance diff. score0.20.31.80.50.5-0.50.40.40.3-0.1-0.00.0-1.30.2
Locomotion velocity, session 10.20.30.50.40.6-0.60.70.60.50.30.4-0.4-0.50.4
Locomotion distance, session 10.60.82.11.01.0-1.11.00.90.60.70.2-0.5-1.50.7
Locomotion velocity, session 20.00.00.2-0.1-0.10.1-0.1-0.1-0.20.2-0.40.2-0.1-0.1
Locomotion distance, session 22.23.05.21.91.8-2.11.81.81.6-1.11.2-1.4-2.31.8
Locomotion velocity, session 31.51.76.71.01.2-0.91.01.21.2-2.61.4-1.1-0.21.2
Locomotion distance, session 36.36.98.82.72.6-2.62.52.82.6-2.82.8-2.8-1.33.0
Stereotopy head waving bouts, day 30.60.71.9-0.6-0.40.7-0.5-0.9-0.7-0.1-1.21.2-0.6-1.4
Stereotopy head waving duration, day 30.60.81.7-0.9-0.70.9-0.6-1.0-0.80.1-1.11.20.0-1.3
Locomotion velocity, session 70.91.02.10.91.1-1.01.21.00.9-0.80.8-0.6-1.40.9
Locomotion distance, session 71.41.84.51.41.4-1.51.51.31.1-0.70.7-0.9-2.11.4
Stereotopy head waving bouts, day 70.30.30.90.30.5-0.20.50.50.4-0.90.8-0.80.40.3
Stereotopy head waving duration, day 70.10.10.40.10.20.10.20.10.1-0.60.5-0.40.4-0.0
Locomotion velocity, session 80.70.82.61.11.1-1.01.01.00.7-0.30.4-0.5-1.60.6
Locomotion distance, session 83.55.012.12.52.4-2.52.32.22.0-1.61.4-1.5-3.51.9
Degree of sensitization distance1.61.64.0-1.0-1.00.9-0.8-1.2-1.32.0-1.61.4-0.7-1.4
Degree of sensitization stereotypy1.61.73.11.11.3-1.01.31.31.3-1.41.8-1.70.11.3
Conditioned locomotion3.84.45.42.22.3-2.12.32.12.2-1.92.2-2.0-2.11.6
Cocaine response after cond. corrected0.00.00.1-0.2-0.20.2-0.2-0.2-0.2-0.0-0.40.3-0.1-0.4
Cocaine response after cond. not corrected0.10.10.3-0.4-0.40.3-0.3-0.3-0.40.6-0.50.30.2-0.4
Cocaine response before conditioning0.20.21.3-0.4-0.40.3-0.2-0.3-0.41.2-0.40.10.5-0.1
Saline control response6.48.610.43.03.2-3.03.23.13.2-2.83.0-2.7-2.32.7
Bone: connectivity density0.40.72.70.90.7-0.80.50.70.7-1.70.3-0.4-1.10.6
Bone: cortical apparent density0.50.71.90.60.6-0.80.70.90.80.51.0-1.40.31.2
Bone: cortical area3.45.26.32.32.2-2.42.12.32.5-2.42.5-2.3-1.72.2
Bone: cortical porosity0.40.53.1-0.7-0.50.7-0.5-0.4-0.2-0.30.1-0.11.8-0.1
Bone: cortical porosity0.30.31.2-0.10.10.10.00.20.3-1.10.6-0.61.10.4
Bone: cortical thickness1.42.44.31.41.3-1.51.31.51.7-2.11.8-1.7-0.61.6
Bone: cortical thickness0.30.41.10.40.3-0.50.30.50.6-1.10.7-0.60.20.8
Bone: cortical tissue density0.40.61.50.50.5-0.60.60.70.70.60.9-1.20.41.1
Condit. Reinf. active minus inactive responses0.70.81.80.80.7-0.90.70.91.0-0.90.6-1.3-0.41.1
Condit. Reinf. active-inactive response ratio1.01.11.81.10.9-1.10.91.01.2-1.40.7-1.1-1.01.1
Condit. Reinf. active responses0.30.41.10.60.5-0.70.60.70.8-0.40.6-1.1-0.10.8
Condit. Reinf. inactive responses0.00.00.4-0.10.0-0.00.10.0-0.00.70.0-0.10.0-0.0
Incentive salience index mean0.30.40.90.60.5-0.70.50.60.9-0.60.4-0.9-0.30.7
Condit. Reinf. lever presses0.00.00.10.10.1-0.10.10.10.4-0.3-0.0-0.30.00.0
Condit. Reinf. active minus inactive responses3.03.85.02.12.0-2.22.12.12.0-0.81.7-2.1-1.92.1
Condit. Reinf. active-inactive response ratio2.73.23.81.81.7-1.91.81.91.8-1.21.6-1.8-1.81.9
Condit. Reinf. active responses4.56.37.92.72.7-2.82.82.72.5-1.02.3-2.6-2.22.7
Condit. Reinf. inactive responses0.81.01.51.11.2-1.11.21.10.9-0.70.9-0.9-0.80.9
Condit. Reinf. lever presses1.11.62.41.11.3-1.31.41.41.3-0.51.6-1.5-0.41.4
Condit. Reinf. lever reinforcers received3.54.86.12.42.4-2.52.52.42.2-0.92.0-2.2-1.92.3
Conditioned reinforcement - actives0.10.21.1-0.4-0.10.3-0.1-0.3-0.3-0.20.10.31.1-0.2
Conditioned reinforcement - inactives0.40.51.20.90.9-0.80.70.50.7-0.90.3-0.2-1.10.2
Conditioned locomotion0.30.40.9-0.9-0.40.6-0.3-0.6-0.2-0.3-0.20.91.0-0.8
Patch foraging indifference point 0 sec0.30.61.40.91.1-0.70.80.50.7-1.00.1-0.0-1.20.1
Patch foraging indifference point AUC0.71.01.61.01.0-1.10.81.10.80.11.1-1.1-0.81.3
Delay disc. indifference point, 0s delay3.13.45.1-2.3-2.12.0-1.9-1.9-1.81.1-1.61.91.5-2.1
Delay disc. indifference point, 16s delay0.70.71.2-1.1-0.80.9-0.8-1.0-0.80.6-0.80.60.9-0.9
Delay disc. indifference point, 2s delay0.10.10.5-0.3-0.30.4-0.4-0.4-0.20.5-0.30.20.2-0.7
Delay disc. indifference point, 24s delay2.22.53.3-1.7-1.71.5-1.8-1.7-1.51.5-1.61.21.5-1.5
Delay disc. indifference point, 4s delay0.00.00.2-0.20.10.10.3-0.10.10.00.1-0.10.4-0.2
Delay disc. indifference point, 8s delay0.80.92.1-1.2-0.81.0-0.8-1.0-0.70.7-0.70.71.4-1.0
Indifference point function ln k0.20.41.70.50.5-0.50.60.40.6-1.30.2-0.2-0.70.1
Indifference point function log k0.20.41.70.50.5-0.50.60.40.6-1.30.2-0.2-0.70.1
Patch foraging total patch changes 0 sec0.40.71.60.91.1-0.80.90.60.8-1.10.2-0.0-1.20.1
Patch foraging total patch changes 12 sec0.40.51.10.70.9-0.70.60.80.7-1.00.7-0.4-0.50.7
Patch foraging total patch changes 18 sec0.30.40.9-0.4-0.40.5-0.5-0.7-0.71.0-0.70.8-0.1-1.0
Patch foraging total patch changes 24 sec0.61.02.1-0.9-0.80.9-1.0-1.1-1.00.7-1.21.50.0-1.5
Patch foraging total patch changes 6 sec1.01.52.31.41.5-1.31.21.21.2-1.40.8-0.6-1.51.0
Patch foraging time to switch 0 sec2.24.57.7-2.5-2.52.4-2.2-2.1-2.11.1-1.81.82.8-1.6
Patch foraging water rate 0 sec4.28.914.03.43.4-3.23.23.12.9-1.82.5-2.6-3.72.4
Patch foraging water rate 12 sec0.40.82.71.10.9-0.90.80.70.41.6-0.0-0.7-1.40.6
Patch foraging water rate 18 sec0.40.61.00.80.9-0.80.70.80.7-0.90.5-0.6-0.81.0
Patch foraging water rate 24 sec0.50.70.90.70.9-0.81.00.80.9-0.50.9-0.9-0.60.8
Patch foraging water rate 6 sec2.02.93.41.81.8-1.81.81.81.8-0.81.8-1.8-1.81.4
Seeking ratio, delayed vs. immediate footshock0.10.20.6-0.6-0.40.3-0.2-0.3-0.40.7-0.30.40.5-0.3
Distance traveled before self-admin4.45.87.02.52.6-2.52.62.42.5-2.22.4-2.2-2.51.9
Distance traveled after self-admin2.02.43.61.41.7-1.41.81.51.5-1.91.7-1.2-1.61.1
Extensor digitorum longus weight0.00.20.50.30.2-0.30.40.50.1-0.10.7-0.6-0.50.4
Bone: elastic displacement0.10.21.0-0.5-0.50.3-0.4-0.2-0.1-0.10.1-0.21.00.2
Bone: elastic work0.10.10.6-0.2-0.30.1-0.3-0.00.0-0.10.3-0.30.80.2
Bone: endosteal estimation0.71.53.01.41.4-1.21.31.21.1-1.01.2-1.1-1.70.8
Bone: endosteal perimeter2.75.77.02.62.6-2.52.52.52.4-2.02.4-2.1-2.72.1
Epididymis fat weight0.10.20.5-0.4-0.60.5-0.4-0.3-0.40.0-0.50.30.7-0.4
Delta time in closed arm before/after self-admin0.70.71.0-0.7-0.90.9-0.9-0.9-0.80.8-0.70.61.0-0.8
Delta time in open arm before/after self-admin1.61.64.61.51.4-1.31.31.30.9-0.40.8-0.9-2.11.0
Diff in mean of infusions in LGA sessions0.30.31.80.50.3-0.40.50.50.21.30.2-0.4-0.30.8
Delay discount exponential model param0.40.50.80.90.6-0.80.60.80.5-0.50.5-0.5-0.90.9
Extinction: sum of active levers before priming1.01.11.90.91.0-1.01.01.21.1-0.61.4-1.0-0.71.3
Active lever presses in extinction session 60.00.00.3-0.3-0.10.0-0.0-0.00.10.0-0.30.5-0.3-0.2
Bone: final force3.15.06.32.22.2-2.32.12.32.5-2.42.3-2.3-1.72.2
Bone: final moment2.43.94.82.01.9-2.01.82.02.2-2.22.1-2.1-1.51.9
Food consumed during 24 hour testing period0.71.01.9-0.9-0.81.0-1.0-1.1-0.90.8-1.11.40.4-1.2
Glucose0.10.20.60.50.4-0.40.40.40.40.00.2-0.2-0.80.2
Heart weight4.67.110.32.92.7-3.02.52.72.8-2.52.1-2.2-3.22.4
Delay discount hyperbolic model param0.40.50.90.90.6-0.80.60.80.5-0.50.6-0.5-0.81.0
Intermittent access intake day 1-15 change0.10.21.30.10.3-0.20.30.20.6-1.20.4-0.30.1-0.0
Intermittent access intake escalation0.10.21.20.10.2-0.10.30.20.5-1.10.5-0.30.3-0.1
Intermittent access intake escalation 20.10.10.30.10.1-0.10.10.10.3-0.50.5-0.30.20.1
Intermitt. access day 1 inactive lever presses0.20.91.91.01.2-0.91.00.70.9-1.40.5-0.5-1.00.5
Intermitt. access day 15 inactive lever presses0.10.20.60.30.4-0.20.1-0.10.2-0.6-0.40.3-0.8-0.7
Intermitt. access escalation Index0.30.40.90.60.4-0.60.40.70.4-1.00.3-0.5-0.61.0
Intermittent access day 1 total infusions0.10.10.8-0.2-0.20.2-0.3-0.2-0.1-0.20.10.10.9-0.2
Intermittent access day 15 total infusions0.00.10.40.10.2-0.10.20.10.2-0.70.2-0.20.3-0.0
Intermittent access terminal intake (last 3 days)0.10.10.40.20.3-0.30.30.20.3-0.60.2-0.20.0-0.1
Intermittent access total infusions0.10.10.40.10.2-0.20.20.10.3-0.70.2-0.10.2-0.1
Intermittent access day 1 locomotion0.10.10.2-0.2-0.20.1-0.2-0.3-0.1-0.4-0.20.40.5-0.2
Intermittent access day 15 total locomotion0.20.41.60.50.7-0.50.70.30.5-1.30.40.2-0.6-0.3
Intermittent access total locomotion0.30.31.90.30.6-0.50.60.30.7-1.40.6-0.0-0.1-0.1
Intermittent access standard deviation0.10.20.40.40.4-0.40.60.40.6-0.20.6-0.4-0.30.3
Left kidney weight0.10.53.00.70.7-0.80.50.50.6-0.50.10.1-1.7-0.0
Right kidney weight0.10.73.60.90.7-0.80.60.60.7-0.60.2-0.1-1.90.2
Cocaine induced anxiety3.65.26.7-2.2-2.32.2-2.4-2.3-2.22.4-2.62.51.5-2.4
Post-drug Anxiety2.93.14.6-1.7-1.91.7-1.9-1.7-1.82.0-2.11.81.0-1.6
Baseline Anxiety0.10.20.40.30.2-0.40.40.40.3-0.20.3-0.6-0.30.6
Tail length3.915.122.03.83.7-3.73.83.94.0-4.74.2-4.1-2.83.7
Length with tail5.825.434.85.04.9-5.05.05.05.3-5.95.2-5.1-4.14.7
Length without tail2.58.110.32.92.9-2.92.92.83.0-3.22.9-2.5-2.72.5
Times rat made contact with spout0.10.10.40.20.20.00.00.00.0-0.5-0.30.3-0.6-0.1
Lifetime Intake0.20.21.20.30.3-0.40.40.30.5-1.10.4-0.2-0.00.1
Liver weight, left0.81.31.61.31.2-1.21.21.21.2-0.81.0-1.1-1.11.0
Liver weight, right0.10.20.40.20.4-0.50.50.50.7-0.50.6-0.5-0.20.5
Locomotor activity0.20.40.90.50.5-0.70.50.60.8-0.60.4-0.7-0.30.9
Locomotor testing distance0.00.00.1-0.1-0.1-0.0-0.2-0.1-0.1-0.2-0.30.1-0.10.0
Locomotor testing rearing0.51.02.01.00.9-1.10.90.91.0-1.40.6-0.8-1.20.7
Locomotion in novel chamber0.00.00.2-0.1-0.2-0.1-0.10.00.0-0.40.0-0.4-0.10.3
Locomotion in novel chamber post-restriction0.60.91.51.11.0-1.00.91.10.8-0.40.7-1.2-0.91.2
Fecal boli incidents, locomotor time 10.00.00.3-0.1-0.00.1-0.10.0-0.10.5-0.10.20.40.1
Change in fecal boli incidents, locomotor task0.10.10.2-0.2-0.00.20.0-0.3-0.30.3-0.50.2-0.1-0.3
Time >=10cm from walls, locomotor time 10.00.00.2-0.0-0.1-0.00.10.10.1-0.20.40.00.50.2
Bouts of movement, locomotor time 12.52.84.6-1.9-1.81.7-1.8-1.6-1.61.5-1.41.52.1-1.5
Total resting periods, locomotor time 12.12.34.3-1.7-1.61.5-1.6-1.5-1.51.6-1.21.22.1-1.2
Rest time, locomotor task time 10.40.51.7-0.6-0.50.6-0.5-0.5-0.71.3-0.70.31.1-0.3
Distance moved, locomotor task time 10.00.10.30.20.2-0.00.10.10.1-0.60.20.1-0.4-0.0
Vertical activity count, locomotor time 10.10.30.90.60.6-0.30.40.30.4-0.90.3-0.1-0.70.0
Time >=10cm from walls, locomotor time 20.00.10.4-0.3-0.10.20.1-0.2-0.3-0.40.00.10.60.0
Bouts of movement, locomotor time 20.61.02.8-1.1-1.11.2-1.0-1.0-1.0-0.1-0.80.61.7-0.8
Total resting periods, locomotor time 20.61.03.1-1.1-1.01.1-1.0-1.0-1.00.0-0.70.51.8-0.7
Rest time, locomotor task time 20.40.51.7-0.7-0.70.6-0.7-0.6-0.50.8-0.60.31.3-0.2
Distance moved, locomotor task time 20.10.20.90.40.4-0.20.30.20.1-0.50.10.3-0.9-0.1
Vertical activity count, locomotor time 20.40.51.51.11.0-0.60.70.60.5-0.70.3-0.2-1.20.2
Light reinforcement 10.51.31.71.11.2-1.11.21.11.2-1.11.2-1.3-0.51.2
Light reinforcement 20.50.81.51.01.0-0.81.00.90.9-0.80.9-1.2-0.50.9
Bone: marrow area0.71.53.01.41.3-1.21.31.21.1-1.01.2-1.0-1.70.8
Bone: maximum diameter4.78.89.73.13.1-3.12.93.03.1-3.03.0-2.8-2.72.7
Bone: maximum force0.91.62.51.21.2-1.31.21.31.5-1.61.3-1.2-1.01.1
Bone: maximum moment0.50.81.70.90.8-0.90.80.91.0-1.31.0-0.8-0.70.7
Mean time between licks in bursts0.00.10.6-0.3-0.30.4-0.2-0.2-0.1-0.8-0.10.20.4-0.2
Mean num. licks in bursts0.40.61.81.01.0-0.80.80.70.5-0.20.1-0.3-1.40.3
Cd content in liver2.52.76.91.61.5-1.61.61.61.7-2.61.5-1.6-0.71.7
Co content in liver2.42.84.11.61.7-1.61.71.71.7-1.41.8-2.0-1.31.9
Cu content in liver3.34.05.02.22.2-2.12.22.21.8-0.41.9-2.1-1.72.2
Fe content in liver0.10.10.20.30.3-0.30.20.30.2-0.20.3-0.3-0.00.5
K content in liver0.60.61.00.80.7-0.90.70.80.8-0.10.6-0.7-1.00.9
Mg content in liver3.43.54.22.01.9-2.01.92.11.9-1.01.8-2.0-1.72.1
Mn content in liver3.13.54.02.01.9-2.02.02.01.9-1.61.8-1.8-1.71.9
Na content in liver0.30.30.4-0.5-0.60.5-0.5-0.5-0.60.6-0.50.7-0.2-0.4
Rb content in liver5.15.98.32.92.7-2.62.62.62.2-1.52.0-2.1-2.82.4
Se content in liver1.21.42.21.31.2-1.41.21.31.2-0.11.3-1.2-0.91.5
Sr content in liver0.70.63.10.50.7-0.40.70.50.6-1.80.9-0.7-0.50.5
Zn content in liver1.21.31.91.21.3-1.21.21.31.3-0.11.2-1.4-0.61.3
Bone: minimum diameter1.83.35.21.91.8-1.81.81.81.8-2.32.0-1.6-1.51.5
Time in familiar zone, hab. session 11.11.01.5-1.0-1.11.0-1.0-1.0-1.21.0-1.11.20.7-0.9
Time in novel zone, hab. session 10.60.61.00.80.9-0.90.90.70.9-0.40.6-0.9-1.00.6
Total zone transitions, hab. session 10.50.61.60.90.8-1.00.80.80.50.50.3-0.7-1.30.9
Total locomotion distance, hab. session 10.40.62.70.70.7-0.90.70.50.40.8-0.1-0.4-1.70.5
Locomotion velocity, hab. session 10.40.62.60.80.7-0.90.70.60.60.3-0.0-0.5-1.60.6
Time in familiar zone, hab. session 21.21.31.8-1.0-1.11.1-1.1-1.1-1.21.4-1.31.30.7-1.1
Time in novel zone, hab. session 21.41.42.61.01.1-1.11.11.21.2-1.61.3-1.4-0.61.2
Total zone transitions, hab. session 22.22.84.21.71.8-1.91.81.91.6-0.21.7-1.8-1.12.1
Total locomotion distance, hab. session 21.11.43.41.31.3-1.51.31.21.10.40.7-0.9-1.81.1
Locomotion velocity, hab. session 20.70.93.21.01.0-1.21.00.90.80.50.3-0.5-1.80.7
Novel to familiar place preference ratio0.10.10.2-0.2-0.20.2-0.3-0.3-0.3-0.0-0.30.5-0.3-0.5
Novelty place preference0.20.20.5-0.4-0.40.5-0.5-0.5-0.60.1-0.50.7-0.1-0.7
Time in novel zone, NPP test0.10.10.3-0.2-0.20.3-0.3-0.3-0.4-0.0-0.30.5-0.2-0.5
Total zone transitions, NPP test0.20.20.50.30.4-0.50.40.50.40.60.3-0.7-0.10.7
Total locomotion distance, NPP test0.60.83.00.90.8-1.10.90.70.70.50.2-0.7-1.70.5
Locomotion velocity, NPP test0.30.41.90.50.5-0.70.50.40.40.8-0.1-0.4-1.40.2
Intraocular pressure0.00.00.1-0.00.20.00.20.1-0.10.20.2-0.20.20.2
Delta distance traveled before/after self-admin0.10.10.30.20.2-0.00.60.3-0.0-0.30.4-0.4-0.30.3
Delta ambulatory time before/after self-admin0.70.91.4-1.0-1.01.2-0.8-0.9-1.21.1-0.70.71.0-0.8
Parametrial fat weight0.30.82.0-0.9-0.81.0-0.9-0.8-0.70.6-0.80.81.4-0.7
Pavlov. Cond. lever latency0.20.20.80.30.4-0.20.50.40.3-0.90.6-0.5-0.00.5
Pavlov. Cond. magazine entry latency0.30.30.50.60.4-0.70.50.60.50.70.4-0.7-0.50.7
Pavlov. Cond. change in total contacts0.10.10.20.40.3-0.40.20.30.20.50.3-0.4-0.50.3
Pavlov. Cond. index score0.10.11.10.1-0.1-0.1-0.1-0.00.01.0-0.2-0.0-0.20.1
Pavlov. Cond. latency score0.20.21.7-0.1-0.30.0-0.3-0.2-0.21.3-0.40.2-0.1-0.2
Pavlov. Cond. lever contacts0.10.10.50.20.0-0.1-0.0-0.00.10.7-0.20.0-0.2-0.0
Pavlov. Cond. magazine entry number0.30.40.8-0.5-0.40.6-0.5-0.7-0.6-0.7-0.70.90.1-0.9
Pavlov. Cond. intertrial magazine entries0.30.41.50.60.6-0.60.50.60.6-1.20.3-0.4-0.50.6
Pavlov. Cond. lever-magazine prob. diff.0.10.10.80.0-0.1-0.1-0.1-0.00.00.9-0.1-0.1-0.00.1
Pavlov. Cond. response bias0.30.30.50.60.5-0.60.50.60.60.30.6-0.7-0.40.7
Pavlov. Cond. lever latency3.44.66.3-2.0-2.22.2-2.3-2.3-2.41.4-2.52.51.0-2.2
Pavlov. Cond. magazine entry latency0.00.00.10.40.4-0.10.20.10.0-0.10.1-0.1-0.2-0.2
Pavlov. Cond. change in total contacts2.33.75.41.92.0-1.92.12.02.1-1.72.2-2.3-0.81.9
Pavlov. Cond. index score2.23.04.21.81.9-1.71.91.81.8-1.22.0-2.1-0.81.6
Pavlov. Cond. latency score1.82.33.11.61.7-1.51.71.61.6-1.11.7-1.8-0.71.4
Pavlov. Cond. lever contacts3.04.15.52.02.1-2.12.22.12.2-1.42.4-2.3-1.12.0
Pavlov. Cond. magazine entry number0.50.61.1-0.9-0.90.7-0.9-0.8-0.80.4-0.81.00.2-0.7
Pavlov. Cond. intertrial magazine entries0.50.82.0-0.7-0.80.7-0.9-0.9-0.91.4-1.20.80.2-0.7
Pavlov. Cond. lever-magazine prob. diff.1.92.53.61.71.7-1.61.81.71.7-1.01.8-1.9-0.61.5
Pavlov. Cond. response bias3.34.46.02.12.2-2.12.32.22.2-1.42.4-2.4-1.22.0
Time in closed arm before self-admin0.60.81.4-1.1-0.90.9-0.8-0.7-1.01.2-0.40.71.2-0.5
Time in closed arm after self-admin2.02.14.2-1.4-1.41.5-1.5-1.3-1.61.9-0.91.02.0-1.0
Time in open arm before self-admin0.30.30.6-0.7-0.60.5-0.6-0.5-0.2-0.6-0.50.60.8-0.4
Time in open arm after self-admin1.01.12.70.91.1-1.11.11.01.2-1.20.5-0.3-1.70.6
Bone: periosteal estimation2.24.75.62.32.2-2.22.22.22.2-2.22.4-2.1-2.01.9
Bone: periosteal perimeter3.45.87.32.62.6-2.52.52.42.4-2.22.4-2.1-2.72.0
Bone: post-yield work0.71.01.9-1.0-0.91.1-1.0-1.1-0.90.1-1.01.20.6-1.4
Progressive ratio test 1 active lever presses1.51.94.61.21.2-1.41.31.31.4-2.11.5-1.2-0.71.3
Progressive ratio test 1 breakpoint1.62.04.81.31.2-1.41.31.31.5-2.21.5-1.3-0.81.4
Progressive ratio test 1 inactive lever presses0.20.41.30.50.6-0.70.60.50.6-1.10.3-0.3-0.50.4
Progressive ratio test 2 active lever presses0.40.51.70.70.7-0.70.70.60.6-1.30.7-0.3-0.40.3
Progressive ratio test 2 breakpoint0.50.61.90.80.7-0.70.70.70.7-1.40.8-0.4-0.50.4
Progressive ratio test 2 inactive lever presses0.81.22.01.31.4-1.21.31.01.1-1.30.8-0.6-1.40.5
Incentive Sensitization - Responses0.10.20.40.70.5-0.40.50.50.2-0.30.6-0.3-0.30.2
Incentive Sensitization - Breakpoint0.10.10.20.50.4-0.20.30.30.0-0.20.4-0.1-0.2-0.0
Sum of active levers in priming session hrs 5-61.11.02.01.01.1-1.01.21.01.1-0.90.7-0.9-1.40.7
Progressive ratio3.96.110.5-2.6-2.32.8-2.1-2.7-2.42.4-2.22.12.1-3.2
Food seeking constrained by brief footshock0.50.62.00.81.0-0.70.90.50.6-0.8-0.0-0.0-1.4-0.3
Seeking ratio, punishment vs. effort3.85.58.32.62.4-2.62.12.42.3-2.91.9-1.6-2.32.5
Retroperitoneal fat weight0.73.14.2-1.8-1.91.8-2.0-1.8-1.40.0-1.92.01.7-1.9
Reaction time number correct0.20.41.10.80.8-0.60.80.60.6-0.40.5-0.4-1.10.1
Reaction time mean minus median0.20.60.9-0.7-0.90.9-0.9-0.9-0.90.4-0.70.80.3-0.9
Reaction time mean minus median AUC0.10.20.5-0.4-0.50.5-0.4-0.6-0.5-0.4-0.40.50.0-0.7
Reaction time num false alarms2.02.83.81.91.9-1.91.91.71.7-1.11.3-1.5-1.81.4
Reaction time num false alarms AUC1.72.63.61.81.9-1.81.91.71.7-0.91.2-1.6-1.61.4
Reaction time trials correct on left0.20.41.10.80.8-0.60.80.60.6-0.40.5-0.4-1.10.1
Reaction time trials on left0.30.51.30.90.9-0.70.90.70.7-0.40.6-0.5-1.10.2
Reaction time mean0.00.00.1-0.1-0.30.1-0.3-0.10.0-0.20.20.00.2-0.0
Reaction time mean AUC0.00.00.1-0.1-0.30.1-0.2-0.2-0.0-0.30.20.00.2-0.1
Median of all reaction times0.00.00.10.1-0.1-0.2-0.10.10.2-0.10.3-0.20.10.2
Reaction time omissions1.21.82.31.41.3-1.41.31.21.4-1.50.7-1.3-1.41.4
Reaction time false alarm rate1.01.41.91.21.3-1.41.31.21.2-0.60.9-1.2-1.01.2
Reaction time premature initiation rate0.20.20.8-0.6-0.50.4-0.4-0.4-0.40.9-0.40.20.6-0.1
Reaction time premature initiations0.10.10.5-0.4-0.30.2-0.2-0.3-0.20.7-0.30.20.2-0.2
Std. dev. reaction times0.10.21.10.20.1-0.30.20.20.5-1.00.5-0.5-0.00.4
Reaction time trials completed0.30.51.30.90.9-0.70.90.70.7-0.40.6-0.5-1.10.2
Reaction time trials AUC0.30.61.30.90.9-0.70.90.70.8-0.40.6-0.5-1.10.2
Run reversals in cocaine runway, females0.10.10.30.40.2-0.2-0.00.10.0-0.3-0.30.1-0.50.1
Run reversals in cocaine runway, males1.31.32.11.21.1-1.41.11.31.2-0.50.8-1.0-1.41.3
Latency to leave start box in cocaine runway0.50.60.9-0.8-0.70.8-0.9-0.7-0.80.8-0.60.80.8-0.3
Latency to leave start box in cocaine runway, F1.51.72.7-1.4-1.31.3-1.5-1.1-1.41.6-1.11.31.4-0.6
Latency to leave start box in cocaine runway, M0.50.41.30.70.6-0.50.60.50.6-1.10.7-0.7-0.30.5
Std. dev. time between licks in bursts0.40.50.90.60.7-0.70.70.70.7-0.90.8-0.5-0.90.5
Total sessions with >9 infusions0.20.31.30.20.2-0.30.30.40.4-1.10.8-0.30.20.4
Short access day 1 total inactive lever presses2.02.63.4-1.9-1.71.5-1.8-1.9-1.40.5-1.81.81.4-1.8
Short access day 10 total inactive lever presses0.81.82.7-1.2-1.21.3-1.5-1.5-1.41.2-1.61.50.8-1.5
Short access day 1 total infusions0.10.10.2-0.3-0.30.1-0.4-0.2-0.1-0.4-0.20.40.0-0.4
Short access day 10 total infusions0.30.41.3-0.8-0.70.5-0.6-0.6-0.3-0.5-0.30.41.1-0.5
Short access total infusions0.10.10.8-0.0-0.1-0.1-0.00.10.2-0.90.3-0.10.20.1
Short access day 1 locomotion0.40.51.6-0.8-0.60.6-0.7-0.7-0.60.3-0.81.20.2-0.9
Short access day 10 total locomotion0.00.00.1-0.10.1-0.00.1-0.20.2-0.4-0.00.20.1-0.3
Short access total locomotion0.00.00.2-0.1-0.1-0.10.0-0.10.2-0.4-0.00.3-0.1-0.2
One hour access (0.3 mA shock)0.00.00.10.10.1-0.2-0.00.00.1-0.3-0.10.10.2-0.0
Compulsive drug intake1.41.72.3-1.3-1.31.2-1.5-1.4-1.20.8-1.51.31.3-1.3
One hour access (shock baseline)0.40.60.80.80.8-0.70.90.80.7-0.70.8-0.7-0.50.6
Social response proportion1.82.13.71.81.7-1.41.71.51.3-0.90.9-1.2-1.91.1
Social responses4.76.07.22.72.6-2.52.62.62.5-2.02.2-2.4-2.22.5
Social time0.50.72.30.80.7-0.80.90.80.51.50.6-0.8-0.50.7
Soleus weight0.10.31.40.50.4-0.50.50.30.10.90.2-0.2-1.20.1
Bone: stiffness2.13.44.11.91.9-1.91.91.92.0-1.71.9-1.8-1.61.7
Tibialis anterior weight1.13.85.02.01.9-2.12.02.11.8-0.82.0-2.2-1.82.2
Time to tail flick, vehicle, before self-admin1.31.42.3-1.1-1.21.1-1.0-1.2-1.31.5-1.31.30.5-1.3
Time to tail flick, vehicle, after self-admin0.91.21.8-1.4-1.31.3-1.3-1.1-1.10.7-0.61.00.8-1.1
Time to tail flick, test, before self-admin0.90.91.91.10.9-0.80.81.01.0-1.00.9-1.40.11.2
Time to tail flick, test, after self-admin0.20.20.6-0.2-0.30.4-0.4-0.5-0.60.1-0.80.4-0.1-0.6
Delta time to tail flick, vehicle, before/after SA2.12.02.71.31.4-1.31.31.51.5-1.61.6-1.5-1.11.4
Delta time to tail flick, test, before/after SA0.60.61.4-0.6-0.60.7-0.7-0.8-0.90.4-1.01.1-0.3-1.2
Tibia length4.011.014.93.23.3-3.13.33.63.2-3.53.9-3.7-1.83.6
Ambulatory time before self-admin2.53.84.71.92.1-1.92.01.92.1-2.22.2-1.9-1.71.5
Ambulatory time after self-admin2.63.04.11.71.8-1.62.01.91.6-1.32.0-1.7-1.71.5
Bone: tissue strength0.20.20.60.30.4-0.40.40.30.5-0.80.4-0.2-0.30.1
Total heroin consumption3.13.64.41.81.9-2.12.02.02.1-1.21.6-1.7-2.02.1
Bone: trabecular number1.22.02.71.41.4-1.61.31.41.5-1.61.1-1.3-1.71.3
Bone: trabecular spacing0.30.43.1-0.5-0.50.4-0.3-0.4-0.51.8-0.20.10.6-0.1
Bone: trabecular thickness1.11.34.91.21.0-1.10.81.01.2-2.20.7-0.8-1.10.9
Bone: trabecular tissue density1.82.73.31.81.8-1.81.71.71.7-1.01.5-1.7-1.71.5
Water consumed over 24 hours0.10.10.2-0.5-0.30.4-0.3-0.3-0.2-0.2-0.30.50.3-0.3
Number of responses in last shaping day0.10.10.20.20.2-0.20.40.20.10.30.2-0.3-0.40.2