Hub : Genes

LOC108350383

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Brain intron excision ratio chr3_47822748_47823168 0.09 0.06 1.8e-07 0.05 0.07 0.07 0.07 1.7e-05 3.1e-07 2.1e-07 4.0e-07
2 BLA intron excision ratio chr3_47822748_47823168 0.08 0.05 2.7e-04 0.05 0.05 0.06 0.05 1.2e-03 1.3e-03 6.9e-04 1.3e-03
3 Brain intron excision ratio chr3_47822820_47823168 0.04 0.03 1.1e-04 0.02 0.04 0.03 0.03 1.1e-02 2.5e-04 2.0e-03 1.8e-03
4 Brain gene expression LOC108350383 0.12 0.06 9.3e-15 0.16 0.16 0.14 0.16 2.1e-14 7.5e-15 6.7e-13 1.4e-14
5 pVTA intron excision ratio chr3_47822820_47823168 0.06 0.04 3.5e-03 0.02 0.04 0.01 0.02 4.6e-02 1.2e-02 9.0e-02 5.1e-02
6 pVTA gene expression LOC108350383 0.06 0.04 3.3e-03 0.03 0.04 0.02 0.03 2.1e-02 7.5e-03 4.2e-02 2.2e-02
7 NAcc gene expression LOC108350383 0.04 0.03 7.0e-07 0.05 0.05 0.04 0.05 4.8e-06 1.1e-06 5.3e-06 2.7e-06
8 LHb gene expression LOC108350383 0.36 0.16 3.3e-07 0.15 0.22 0.17 0.24 1.7e-04 4.8e-06 6.8e-05 2.6e-06
9 IL gene expression LOC108350383 0.18 0.12 2.0e-03 0.12 0.05 0.07 0.09 7.8e-04 2.4e-02 1.0e-02 4.6e-03
10 OFC intron excision ratio chr3_47822748_47823168 0.12 0.08 8.5e-03 0.09 0.07 0.07 0.07 4.5e-03 1.1e-02 9.3e-03 8.5e-03
11 PL gene expression LOC108350383 0.1 0.06 3.9e-16 0.15 0.15 0.15 0.15 2.3e-16 2.9e-16 7.5e-16 9.9e-16
12 PL intron excision ratio chr3_47822820_47823168 0.04 0.03 3.6e-05 0.03 0.04 0.03 0.03 2.8e-04 4.4e-05 8.0e-04 2.9e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bone: apparent density0.10.20.7-0.8-0.8-0.50.4-0.40.30.40.3-0.4-0.3-0.2-0.5
Area under the delay curve0.30.40.60.70.60.5-0.60.6-0.6-0.6-0.70.30.80.70.4
BMI with tail0.10.41.21.10.10.8-0.40.4-0.5-0.7-0.70.40.40.71.0
BMI without tail0.10.20.40.1-0.4-0.30.3-0.30.30.40.3-0.6-0.6-0.4-0.5
Body weight0.41.53.7-1.0-1.9-1.11.5-1.41.31.11.0-1.1-1.2-1.1-0.6
Weight adjusted by age0.80.92.11.21.40.9-1.11.0-1.0-0.9-0.80.90.70.90.6
Bone surface0.91.62.2-1.5-1.4-1.31.2-1.21.21.21.1-1.2-1.1-1.1-1.3
Bone volume0.50.81.8-1.2-1.3-0.90.9-0.80.80.80.7-0.9-0.7-0.6-0.8
Breakpoint value in progressive ratio session4.75.26.81.62.42.2-2.32.3-2.3-2.3-2.42.62.52.12.1
Number of licking bursts0.00.00.10.20.2-0.10.1-0.10.10.10.3-0.2-0.2-0.2-0.2
Context. condit. distance diff. score0.00.00.1-0.1-0.0-0.0-0.10.1-0.1-0.1-0.00.30.10.10.0
Locomotion velocity, session 10.40.40.7-0.4-0.2-0.60.6-0.60.60.70.8-0.7-0.8-0.8-0.8
Locomotion distance, session 10.10.10.2-0.4-0.2-0.40.2-0.20.30.30.3-0.3-0.3-0.4-0.5
Locomotion velocity, session 21.92.23.01.31.71.4-1.61.6-1.6-1.5-1.41.61.51.41.2
Locomotion distance, session 20.20.20.9-1.0-0.6-0.60.5-0.40.40.40.2-0.2-0.2-0.3-0.5
Locomotion velocity, session 30.80.91.20.81.10.9-1.01.0-1.0-1.0-0.91.01.00.90.8
Locomotion distance, session 30.30.30.5-0.4-0.3-0.50.5-0.50.50.60.7-0.6-0.6-0.7-0.6
Stereotopy head waving bouts, day 30.30.31.0-0.8-1.0-0.60.7-0.60.60.40.3-0.4-0.4-0.3-0.2
Stereotopy head waving duration, day 30.10.10.3-0.5-0.5-0.40.4-0.30.30.30.1-0.2-0.2-0.1-0.1
Locomotion velocity, session 70.00.00.00.10.20.0-0.10.1-0.1-0.0-0.00.0-0.00.0-0.1
Locomotion distance, session 70.00.00.00.10.10.0-0.10.1-0.1-0.0-0.00.1-0.10.10.1
Stereotopy head waving bouts, day 70.20.20.4-0.6-0.6-0.50.5-0.50.50.50.4-0.5-0.3-0.5-0.5
Stereotopy head waving duration, day 70.50.61.0-1.0-1.0-0.80.8-0.70.70.70.6-0.9-0.5-0.7-0.7
Locomotion velocity, session 80.00.10.1-0.20.30.1-0.20.3-0.3-0.2-0.20.40.30.10.0
Locomotion distance, session 80.10.10.3-0.10.10.2-0.30.3-0.3-0.3-0.30.50.40.30.3
Degree of sensitization distance0.70.71.10.50.50.7-0.70.8-0.8-0.9-1.01.00.91.11.0
Degree of sensitization stereotypy0.00.00.0-0.1-0.00.1-0.00.0-0.0-0.1-0.00.00.2-0.10.0
Conditioned locomotion0.60.71.20.20.60.7-0.90.9-0.9-0.9-1.10.91.01.10.7
Cocaine response after cond. corrected8.39.311.12.72.93.1-3.03.0-3.0-3.1-3.13.33.13.13.2
Cocaine response after cond. not corrected5.35.97.41.82.12.3-2.32.4-2.4-2.5-2.62.72.62.62.6
Cocaine response before conditioning2.42.94.1-2.0-2.0-1.91.7-1.71.71.71.4-1.6-1.4-1.4-1.6
Saline control response0.20.30.40.30.40.6-0.50.5-0.6-0.6-0.60.60.50.60.6
Bone: connectivity density0.10.20.4-0.6-0.5-0.50.4-0.30.30.40.4-0.4-0.4-0.4-0.7
Bone: cortical apparent density0.20.20.3-0.4-0.5-0.50.4-0.40.40.50.5-0.4-0.4-0.4-0.5
Bone: cortical area3.55.38.0-2.5-2.8-2.32.4-2.42.32.22.1-2.3-2.1-2.2-2.0
Bone: cortical porosity2.62.83.9-1.8-2.0-1.71.8-1.71.71.61.6-1.7-1.6-1.5-1.5
Bone: cortical porosity5.05.46.5-2.4-2.5-2.32.4-2.42.42.32.3-2.2-2.3-2.2-2.2
Bone: cortical thickness2.33.76.3-2.1-2.5-1.92.1-2.01.91.81.8-1.8-1.7-1.7-1.5
Bone: cortical thickness5.96.89.2-2.6-3.0-2.62.8-2.72.72.52.5-2.5-2.5-2.5-2.3
Bone: cortical tissue density0.10.10.2-0.3-0.4-0.40.3-0.30.30.40.4-0.3-0.3-0.3-0.5
Condit. Reinf. active minus inactive responses6.67.410.4-3.2-3.0-2.72.8-2.72.72.62.5-2.4-2.6-2.6-2.6
Condit. Reinf. active-inactive response ratio2.62.84.0-1.8-2.0-1.61.7-1.71.71.61.6-1.5-1.6-1.7-1.5
Condit. Reinf. active responses5.06.17.6-2.8-2.5-2.52.4-2.42.42.52.3-2.3-2.5-2.5-2.5
Condit. Reinf. inactive responses1.41.61.9-1.2-1.1-1.31.2-1.21.31.31.3-1.3-1.4-1.3-1.3
Incentive salience index mean6.27.59.9-3.2-3.0-2.82.7-2.72.72.72.6-2.5-2.7-2.7-2.7
Condit. Reinf. lever presses0.91.21.3-1.1-1.2-1.11.1-1.11.11.11.1-1.1-1.1-1.1-1.1
Condit. Reinf. active minus inactive responses3.44.25.5-2.3-2.2-2.22.0-2.02.02.01.8-2.0-1.9-1.8-2.1
Condit. Reinf. active-inactive response ratio2.22.32.8-1.7-1.5-1.61.5-1.41.51.51.4-1.4-1.4-1.4-1.7
Condit. Reinf. active responses2.94.15.4-2.3-2.3-2.12.1-2.02.02.01.8-2.0-1.9-1.8-1.8
Condit. Reinf. inactive responses0.10.10.3-0.4-0.5-0.20.3-0.30.20.10.1-0.3-0.1-0.10.1
Condit. Reinf. lever presses2.33.15.3-2.3-2.0-2.01.8-1.71.71.71.4-1.7-1.6-1.4-1.7
Condit. Reinf. lever reinforcers received1.82.53.4-1.9-1.8-1.71.6-1.61.51.61.4-1.6-1.4-1.4-1.5
Conditioned reinforcement - actives0.70.71.9-0.8-1.1-0.90.8-0.80.80.80.7-1.4-0.6-0.4-0.8
Conditioned reinforcement - inactives0.10.10.30.50.2-0.20.2-0.20.20.20.4-0.1-0.2-0.2-0.1
Conditioned locomotion0.00.10.2-0.3-0.30.00.00.0-0.1-0.1-0.3-0.40.10.40.3
Patch foraging indifference point 0 sec0.10.10.5-0.4-0.7-0.10.3-0.30.30.20.2-0.3-0.3-0.20.1
Patch foraging indifference point AUC0.10.10.70.20.8-0.2-0.40.4-0.20.1-0.0-0.20.1-0.1-0.7
Delay disc. indifference point, 0s delay0.00.00.0-0.2-0.2-0.00.0-0.00.00.00.0-0.1-0.0-0.00.1
Delay disc. indifference point, 16s delay0.00.00.10.2-0.20.00.1-0.10.0-0.0-0.1-0.20.00.10.0
Delay disc. indifference point, 2s delay0.20.20.7-0.2-0.0-0.40.4-0.40.50.50.5-0.8-0.5-0.5-0.7
Delay disc. indifference point, 24s delay0.60.50.70.70.70.6-0.90.9-0.8-0.7-0.80.40.80.80.5
Delay disc. indifference point, 4s delay0.80.81.61.21.10.9-1.00.9-0.9-0.8-0.80.51.00.80.6
Delay disc. indifference point, 8s delay0.40.40.60.60.50.6-0.60.6-0.6-0.6-0.70.50.80.70.5
Indifference point function ln k0.20.30.5-0.5-0.7-0.30.7-0.70.60.40.6-0.3-0.6-0.6-0.0
Indifference point function log k0.20.30.5-0.5-0.7-0.30.7-0.70.60.40.6-0.3-0.6-0.6-0.0
Patch foraging total patch changes 0 sec0.00.00.20.0-0.20.3-0.00.0-0.1-0.2-0.10.10.10.20.4
Patch foraging total patch changes 12 sec0.81.01.3-1.1-0.9-1.11.0-1.01.01.01.0-0.9-0.8-1.1-1.1
Patch foraging total patch changes 18 sec0.91.21.6-1.3-1.0-1.21.1-1.01.01.11.0-1.1-1.1-1.0-1.1
Patch foraging total patch changes 24 sec1.11.42.7-1.6-1.3-1.31.2-1.21.11.11.0-1.0-1.0-1.0-1.1
Patch foraging total patch changes 6 sec0.20.30.40.50.50.6-0.60.6-0.6-0.5-0.60.50.40.50.5
Patch foraging time to switch 0 sec0.10.20.80.5-0.30.5-0.10.2-0.3-0.5-0.50.40.40.50.9
Patch foraging water rate 0 sec2.23.54.2-2.1-1.8-2.01.9-1.91.91.91.9-1.7-1.8-1.9-1.9
Patch foraging water rate 12 sec2.33.54.3-1.8-1.6-1.92.0-2.02.01.92.0-1.4-1.9-2.1-1.8
Patch foraging water rate 18 sec4.45.96.4-2.5-2.5-2.52.5-2.52.52.42.4-2.2-2.4-2.4-2.4
Patch foraging water rate 24 sec2.12.93.7-1.4-1.4-1.71.7-1.71.71.81.8-1.8-1.6-1.9-1.8
Patch foraging water rate 6 sec3.55.16.4-1.9-1.8-2.32.3-2.42.42.42.5-2.0-2.4-2.5-2.2
Seeking ratio, delayed vs. immediate footshock0.20.20.6-0.8-0.5-0.50.5-0.50.50.40.7-0.5-0.3-0.3-0.3
Distance traveled before self-admin6.06.48.0-2.5-2.8-2.62.8-2.82.72.62.4-1.5-2.6-2.6-2.1
Distance traveled after self-admin3.94.35.1-2.0-2.2-2.12.2-2.12.12.11.9-2.0-2.3-2.0-1.9
Extensor digitorum longus weight0.31.11.4-0.9-1.2-1.01.1-1.11.11.01.1-0.9-1.0-1.1-0.8
Bone: elastic displacement0.10.10.50.70.30.5-0.30.3-0.3-0.4-0.20.10.20.20.5
Bone: elastic work0.00.00.20.5-0.10.10.0-0.10.10.00.2-0.3-0.2-0.20.1
Bone: endosteal estimation0.41.01.3-1.1-0.8-1.10.9-0.90.91.00.9-1.1-0.9-1.0-1.1
Bone: endosteal perimeter0.91.92.8-1.7-1.2-1.61.3-1.31.31.41.3-1.5-1.3-1.3-1.5
Epididymis fat weight8.219.024.75.04.54.6-4.44.3-4.3-4.3-4.14.24.34.04.3
Delta time in closed arm before/after self-admin0.40.40.70.60.30.7-0.60.7-0.7-0.7-0.80.30.60.70.8
Delta time in open arm before/after self-admin1.41.31.6-1.0-1.2-1.11.2-1.21.21.21.3-1.1-1.2-1.1-1.1
Diff in mean of infusions in LGA sessions10.111.113.22.83.13.5-3.53.5-3.5-3.5-3.62.73.53.53.2
Delay discount exponential model param0.40.40.7-0.9-0.7-0.60.7-0.70.70.60.7-0.4-0.8-0.7-0.4
Extinction: sum of active levers before priming0.20.21.2-0.70.1-0.10.1-0.0-0.0-0.1-0.11.10.3-0.20.3
Active lever presses in extinction session 60.10.10.6-0.8-0.8-0.00.3-0.20.1-0.1-0.10.00.20.20.5
Bone: final force3.35.35.6-2.4-2.4-2.42.3-2.32.32.32.3-2.3-2.2-2.3-2.3
Bone: final moment3.25.15.5-2.3-2.3-2.32.3-2.32.32.32.2-2.3-2.2-2.3-2.3
Food consumed during 24 hour testing period0.40.51.6-1.3-1.0-0.80.7-0.60.60.60.5-0.4-0.4-0.5-0.6
Glucose0.71.11.7-1.2-1.3-1.01.1-1.11.01.00.9-1.1-0.9-0.9-0.9
Heart weight0.10.10.6-0.10.10.2-0.00.0-0.1-0.2-0.10.80.10.10.5
Delay discount hyperbolic model param0.30.40.7-0.8-0.7-0.50.6-0.60.60.50.6-0.3-0.7-0.6-0.3
Intermittent access intake day 1-15 change4.14.14.6-1.6-1.9-2.12.1-2.12.12.12.1-1.9-1.8-2.2-2.0
Intermittent access intake escalation3.73.74.2-1.5-1.8-2.02.0-2.02.12.02.0-1.8-1.7-2.1-1.9
Intermittent access intake escalation 23.63.54.4-1.4-1.6-1.81.9-2.02.02.02.1-1.9-1.7-2.1-1.9
Intermitt. access day 1 inactive lever presses0.60.61.11.10.80.8-0.70.7-0.7-0.8-0.60.90.80.61.0
Intermitt. access day 15 inactive lever presses0.00.00.1-0.0-0.1-0.00.0-0.00.00.10.2-0.3-0.10.0-0.0
Intermitt. access escalation Index1.21.02.0-0.9-1.0-0.91.0-1.01.01.00.9-1.0-1.4-0.8-1.0
Intermittent access day 1 total infusions0.20.20.6-0.00.10.4-0.40.4-0.5-0.5-0.5-0.10.50.80.6
Intermittent access day 15 total infusions1.11.22.0-1.4-1.3-1.21.2-1.11.11.01.0-1.2-0.8-0.8-0.9
Intermittent access terminal intake (last 3 days)2.22.53.5-1.9-1.6-1.61.6-1.61.51.51.5-1.9-1.3-1.3-1.4
Intermittent access total infusions0.60.61.5-1.2-0.9-0.80.8-0.70.70.60.6-1.1-0.5-0.4-0.6
Intermittent access day 1 locomotion1.11.22.30.50.71.1-1.01.0-1.1-1.2-1.30.81.11.31.5
Intermittent access day 15 total locomotion0.20.31.1-1.0-0.8-0.50.5-0.50.40.40.3-0.4-0.2-0.2-0.1
Intermittent access total locomotion0.10.10.3-0.40.00.3-0.20.3-0.3-0.4-0.5-0.00.40.50.6
Intermittent access standard deviation1.92.02.4-1.5-1.5-1.51.5-1.51.51.41.4-1.3-1.4-1.4-1.1
Left kidney weight0.61.72.5-1.5-1.5-1.41.6-1.51.51.31.3-0.7-1.2-1.2-0.9
Right kidney weight0.61.72.3-1.1-1.4-1.31.5-1.51.41.31.4-0.8-1.3-1.4-0.9
Cocaine induced anxiety0.30.30.50.70.50.7-0.60.5-0.6-0.6-0.5-0.10.50.40.5
Post-drug Anxiety0.40.40.70.50.50.8-0.70.7-0.7-0.7-0.70.50.60.60.8
Baseline Anxiety0.10.10.3-0.2-0.2-0.10.2-0.20.20.10.20.5-0.2-0.20.2
Tail length2.36.98.1-2.8-2.5-2.82.5-2.52.62.72.6-2.5-2.6-2.6-2.9
Length with tail1.34.75.8-2.4-2.4-2.22.3-2.32.22.12.2-1.8-1.9-2.1-1.9
Length without tail0.71.62.9-1.3-1.7-1.21.5-1.51.41.11.3-0.8-1.0-1.2-0.6
Times rat made contact with spout4.65.36.21.82.22.2-2.32.3-2.3-2.4-2.52.52.52.42.3
Lifetime Intake1.01.12.5-1.6-1.3-1.11.1-1.01.00.90.9-1.3-0.8-0.6-0.8
Liver weight, left0.10.10.20.40.20.3-0.30.3-0.3-0.3-0.30.30.30.20.4
Liver weight, right0.10.10.40.30.00.3-0.10.2-0.2-0.3-0.20.70.30.20.6
Locomotor activity2.64.15.0-2.2-2.2-2.22.1-2.12.12.11.9-1.6-2.0-1.9-2.0
Locomotor testing distance5.59.210.4-3.2-3.2-3.13.1-3.13.13.02.9-2.7-3.0-3.0-2.9
Locomotor testing rearing6.29.511.1-3.3-3.3-3.23.2-3.13.13.13.0-2.7-3.0-3.1-2.9
Locomotion in novel chamber0.91.12.20.50.40.9-0.80.9-1.0-1.1-1.51.31.11.31.1
Locomotion in novel chamber post-restriction0.81.02.8-0.3-1.4-0.81.0-1.01.00.90.9-1.7-0.7-0.9-0.7
Fecal boli incidents, locomotor time 10.20.20.50.60.2-0.10.2-0.30.40.50.7-0.4-0.1-0.7-0.5
Change in fecal boli incidents, locomotor task0.10.10.7-0.8-0.7-0.40.3-0.20.20.2-0.0-0.1-0.1-0.1-0.1
Time >=10cm from walls, locomotor time 10.50.50.9-0.7-0.9-0.60.7-0.70.70.60.7-0.7-0.5-0.6-0.5
Bouts of movement, locomotor time 12.93.15.12.32.11.9-1.81.7-1.7-1.7-1.51.41.71.61.6
Total resting periods, locomotor time 12.42.74.82.21.91.8-1.61.6-1.6-1.6-1.41.21.61.41.5
Rest time, locomotor task time 12.62.94.52.12.11.8-1.81.7-1.7-1.6-1.51.41.61.51.5
Distance moved, locomotor task time 13.63.95.9-2.0-2.4-2.02.1-2.02.01.91.8-1.9-2.2-1.8-1.7
Vertical activity count, locomotor time 10.70.70.9-0.8-0.9-0.80.8-0.90.80.80.9-0.8-1.0-0.8-0.7
Time >=10cm from walls, locomotor time 20.10.10.5-0.7-0.4-0.30.2-0.10.10.10.00.40.10.20.0
Bouts of movement, locomotor time 21.51.63.51.91.41.5-1.11.1-1.1-1.2-0.91.50.91.01.3
Total resting periods, locomotor time 21.71.84.52.11.51.6-1.21.2-1.2-1.3-1.01.40.91.01.4
Rest time, locomotor task time 20.70.82.41.61.01.0-0.90.8-0.8-0.8-0.60.50.60.50.8
Distance moved, locomotor task time 21.11.32.2-1.4-1.5-1.21.2-1.21.11.00.9-0.9-1.2-0.9-0.9
Vertical activity count, locomotor time 20.00.00.10.00.20.1-0.00.0-0.1-0.0-0.00.0-0.30.10.0
Light reinforcement 10.20.40.5-0.7-0.6-0.60.6-0.60.60.60.7-0.7-0.7-0.6-0.7
Light reinforcement 20.40.51.4-0.8-0.1-0.70.4-0.50.50.70.8-0.8-0.9-0.7-1.2
Bone: marrow area0.51.11.4-1.1-0.8-1.20.9-0.91.01.01.0-1.1-1.0-1.1-1.2
Bone: maximum diameter1.62.94.4-2.0-2.1-1.81.7-1.71.71.61.5-1.7-1.5-1.6-1.5
Bone: maximum force3.66.27.0-2.3-2.6-2.52.5-2.52.52.52.5-2.5-2.4-2.6-2.4
Bone: maximum moment3.56.06.9-2.2-2.5-2.42.5-2.52.52.52.5-2.5-2.4-2.6-2.4
Mean time between licks in bursts0.00.00.1-0.2-0.0-0.10.0-0.00.00.0-0.00.00.00.1-0.0
Mean num. licks in bursts1.72.02.80.81.01.3-1.31.4-1.4-1.5-1.71.61.61.61.5
Cd content in liver2.02.22.71.51.71.5-1.61.6-1.5-1.5-1.41.31.51.41.3
Co content in liver0.00.10.3-0.5-0.4-0.20.1-0.1-0.0-0.0-0.20.20.20.10.1
Cu content in liver0.40.50.9-0.7-0.4-0.80.6-0.70.70.80.8-0.6-0.7-0.6-1.0
Fe content in liver1.11.31.91.41.41.2-1.21.1-1.1-1.1-0.91.11.00.81.0
K content in liver1.21.21.7-1.2-0.9-1.21.0-1.01.11.21.1-1.1-1.1-0.9-1.3
Mg content in liver1.31.31.8-1.3-1.1-1.31.1-1.11.11.21.1-1.1-1.2-0.9-1.2
Mn content in liver8.79.811.1-3.3-2.9-3.23.1-3.13.13.23.1-3.2-3.2-3.0-3.3
Na content in liver4.75.05.6-2.1-2.0-2.32.3-2.32.32.32.4-2.0-2.3-2.2-2.3
Rb content in liver0.30.40.5-0.7-0.7-0.70.7-0.60.60.60.5-0.6-0.5-0.5-0.5
Se content in liver0.70.81.30.50.80.9-0.90.9-0.9-1.0-0.91.11.00.90.9
Sr content in liver1.21.11.6-1.2-1.2-1.11.1-1.11.01.01.0-1.0-1.0-0.9-1.0
Zn content in liver0.60.71.10.40.40.7-0.70.8-0.8-0.9-1.01.10.91.10.9
Bone: minimum diameter0.91.72.0-1.2-1.4-1.31.3-1.31.31.31.2-1.4-1.3-1.3-1.2
Time in familiar zone, hab. session 10.20.20.3-0.00.40.2-0.40.5-0.4-0.3-0.50.50.50.50.1
Time in novel zone, hab. session 10.40.40.80.90.60.8-0.50.5-0.5-0.6-0.50.40.50.50.8
Total zone transitions, hab. session 11.41.93.5-1.9-1.6-1.51.4-1.31.31.31.1-1.2-1.2-1.2-1.4
Total locomotion distance, hab. session 11.42.02.9-1.7-1.3-1.61.3-1.31.31.41.3-1.4-1.3-1.4-1.6
Locomotion velocity, hab. session 11.31.82.4-1.6-1.3-1.41.3-1.31.31.41.2-1.3-1.2-1.3-1.5
Time in familiar zone, hab. session 22.62.72.91.61.71.6-1.71.7-1.7-1.6-1.61.71.71.61.6
Time in novel zone, hab. session 21.71.72.3-1.4-1.5-1.31.4-1.41.31.31.2-1.2-1.2-1.2-1.1
Total zone transitions, hab. session 21.01.42.3-1.5-1.4-1.21.2-1.21.11.11.0-1.1-0.9-1.1-1.0
Total locomotion distance, hab. session 20.70.91.1-1.0-0.9-0.90.9-1.00.90.90.9-0.9-0.8-1.0-0.9
Locomotion velocity, hab. session 20.50.70.9-0.8-0.7-0.80.8-0.80.80.80.8-0.9-0.7-0.9-0.8
Novel to familiar place preference ratio0.70.71.30.80.40.9-0.70.7-0.8-0.9-0.90.80.90.91.2
Novelty place preference0.80.81.50.80.51.0-0.80.8-0.8-1.0-1.00.80.90.91.2
Time in novel zone, NPP test0.80.81.60.80.51.0-0.70.8-0.8-1.0-1.00.80.90.91.3
Total zone transitions, NPP test0.00.10.3-0.5-0.4-0.30.2-0.20.10.20.1-0.1-0.0-0.2-0.3
Total locomotion distance, NPP test0.70.91.3-1.0-0.8-1.00.9-0.90.91.00.9-0.8-0.9-1.1-1.1
Locomotion velocity, NPP test0.71.01.5-1.0-0.9-1.10.9-1.01.01.11.0-0.9-1.0-1.1-1.2
Intraocular pressure1.72.32.7-1.4-1.6-1.61.6-1.61.61.51.6-1.3-1.4-1.6-1.4
Delta distance traveled before/after self-admin0.80.91.21.01.11.0-1.11.1-1.1-1.0-0.90.40.81.10.7
Delta ambulatory time before/after self-admin0.00.00.3-0.00.0-0.1-0.00.0-0.00.10.1-0.5-0.30.1-0.2
Parametrial fat weight4.79.211.33.43.33.1-3.13.1-3.0-3.0-2.83.02.82.92.8
Pavlov. Cond. lever latency0.30.41.00.91.00.6-0.70.7-0.6-0.6-0.50.50.50.50.5
Pavlov. Cond. magazine entry latency0.00.00.10.1-0.40.00.1-0.10.1-0.0-0.0-0.1-0.00.00.2
Pavlov. Cond. change in total contacts1.31.31.8-1.0-1.2-1.11.2-1.21.21.21.2-1.4-1.2-1.1-1.1
Pavlov. Cond. index score0.50.61.1-0.7-1.1-0.80.8-0.80.80.70.7-0.8-0.8-0.7-0.6
Pavlov. Cond. latency score0.40.51.1-0.7-1.0-0.70.8-0.70.70.70.6-0.6-0.7-0.6-0.5
Pavlov. Cond. lever contacts0.91.11.8-1.2-1.4-1.01.1-1.11.01.00.9-0.9-0.9-0.8-0.9
Pavlov. Cond. magazine entry number0.30.40.60.30.60.6-0.60.6-0.6-0.6-0.70.80.70.70.6
Pavlov. Cond. intertrial magazine entries0.81.01.9-1.4-1.2-1.11.0-1.00.91.00.8-0.7-0.8-0.9-0.9
Pavlov. Cond. lever-magazine prob. diff.0.60.71.4-0.8-1.2-0.80.9-0.90.90.80.8-0.9-0.8-0.7-0.6
Pavlov. Cond. response bias0.50.60.9-0.5-0.9-0.70.8-0.80.80.80.8-0.9-0.8-0.8-0.7
Pavlov. Cond. lever latency2.02.65.62.42.11.8-1.71.6-1.5-1.5-1.21.31.31.21.4
Pavlov. Cond. magazine entry latency1.11.32.30.10.40.8-0.91.0-1.1-1.2-1.51.41.51.41.3
Pavlov. Cond. change in total contacts0.40.61.5-1.2-0.8-1.00.8-0.70.70.80.6-0.5-0.6-0.6-0.8
Pavlov. Cond. index score0.10.20.7-0.8-0.4-0.20.10.1-0.2-0.2-0.50.40.50.50.3
Pavlov. Cond. latency score0.20.20.5-0.7-0.2-0.0-0.10.2-0.3-0.4-0.70.50.70.70.5
Pavlov. Cond. lever contacts1.21.74.4-2.1-1.8-1.51.4-1.21.21.10.8-1.0-0.9-0.8-1.0
Pavlov. Cond. magazine entry number1.01.22.0-0.3-0.6-0.80.9-1.01.11.11.4-1.4-1.4-1.4-1.2
Pavlov. Cond. intertrial magazine entries2.12.73.5-1.1-1.5-1.51.6-1.71.71.71.8-1.7-1.9-1.8-1.7
Pavlov. Cond. lever-magazine prob. diff.0.10.20.5-0.7-0.2-0.1-0.00.2-0.2-0.3-0.60.50.60.50.4
Pavlov. Cond. response bias0.40.52.2-1.5-1.2-0.80.7-0.60.50.50.1-0.2-0.2-0.2-0.3
Time in closed arm before self-admin0.30.40.60.60.60.6-0.70.7-0.6-0.6-0.60.60.80.70.4
Time in closed arm after self-admin0.10.10.2-0.0-0.10.2-0.30.3-0.3-0.3-0.50.00.30.40.3
Time in open arm before self-admin1.82.02.71.21.41.3-1.51.5-1.5-1.4-1.71.21.31.51.3
Time in open arm after self-admin0.00.00.1-0.1-0.10.1-0.10.1-0.1-0.2-0.20.00.20.30.3
Bone: periosteal estimation2.34.85.7-2.3-2.4-2.32.2-2.22.22.12.1-2.3-2.1-2.1-2.0
Bone: periosteal perimeter2.64.35.3-2.3-2.2-2.22.1-2.12.02.02.0-2.1-2.0-2.0-2.0
Bone: post-yield work1.31.82.3-1.2-1.3-1.41.3-1.41.41.41.4-1.2-1.3-1.5-1.4
Progressive ratio test 1 active lever presses1.01.11.8-1.2-1.3-1.01.2-1.11.00.90.9-1.3-0.9-0.6-0.7
Progressive ratio test 1 breakpoint2.02.13.0-1.6-1.7-1.41.6-1.51.51.31.4-1.7-1.3-1.1-1.0
Progressive ratio test 1 inactive lever presses0.10.10.30.1-0.10.2-0.10.1-0.1-0.3-0.2-0.10.20.50.5
Progressive ratio test 2 active lever presses0.30.31.5-1.2-0.6-0.60.3-0.30.20.30.1-1.1-0.20.1-0.4
Progressive ratio test 2 breakpoint0.50.51.9-1.4-0.8-0.70.5-0.50.50.50.3-1.3-0.5-0.1-0.6
Progressive ratio test 2 inactive lever presses0.50.61.4-0.9-0.6-0.80.6-0.60.60.70.7-1.2-0.8-0.3-0.7
Incentive Sensitization - Responses0.40.51.5-1.2-0.7-0.70.4-0.40.40.50.2-1.2-0.4-0.1-0.7
Incentive Sensitization - Breakpoint0.50.51.5-1.2-0.7-0.80.5-0.40.40.60.2-1.2-0.5-0.2-0.8
Sum of active levers in priming session hrs 5-61.91.83.71.21.51.4-1.21.2-1.2-1.3-1.31.91.21.11.5
Progressive ratio0.80.91.9-0.8-1.4-0.81.1-1.11.00.80.8-0.9-1.0-0.8-0.4
Food seeking constrained by brief footshock0.10.10.2-0.20.0-0.20.3-0.30.30.30.40.1-0.3-0.2-0.4
Seeking ratio, punishment vs. effort0.30.30.70.50.90.5-0.60.6-0.6-0.5-0.40.90.60.50.2
Retroperitoneal fat weight5.518.219.64.44.24.4-4.34.3-4.2-4.3-4.14.34.24.04.3
Reaction time number correct0.10.10.3-0.3-0.6-0.20.4-0.50.40.30.4-0.2-0.4-0.4-0.1
Reaction time mean minus median1.72.22.91.31.61.4-1.71.7-1.7-1.5-1.71.11.41.61.1
Reaction time mean minus median AUC3.04.04.91.62.21.9-2.22.2-2.2-2.0-2.21.81.92.11.5
Reaction time num false alarms1.72.33.5-1.9-1.4-1.71.4-1.41.51.61.4-1.3-1.5-1.5-1.7
Reaction time num false alarms AUC2.23.04.4-2.1-1.7-1.91.7-1.71.71.71.6-1.6-1.7-1.7-1.8
Reaction time trials correct on left0.10.10.3-0.3-0.6-0.20.4-0.50.40.30.4-0.2-0.4-0.4-0.1
Reaction time trials on left0.10.10.3-0.3-0.6-0.20.4-0.50.40.30.4-0.2-0.4-0.4-0.1
Reaction time mean1.82.64.21.62.11.5-1.91.8-1.8-1.5-1.71.21.61.60.9
Reaction time mean AUC2.63.45.21.82.31.8-2.12.1-2.0-1.8-1.91.41.81.81.2
Median of all reaction times1.11.52.71.31.71.1-1.41.4-1.4-1.1-1.20.81.21.20.6
Reaction time omissions1.72.43.21.61.81.4-1.61.6-1.6-1.5-1.51.51.61.61.2
Reaction time false alarm rate1.11.52.5-1.6-1.1-1.51.1-1.11.11.31.1-1.2-1.2-1.1-1.4
Reaction time premature initiation rate0.40.50.80.80.90.6-0.80.8-0.8-0.7-0.80.60.60.80.5
Reaction time premature initiations0.20.20.30.60.60.4-0.50.5-0.5-0.4-0.50.40.30.50.4
Std. dev. reaction times1.72.43.71.31.91.4-1.81.8-1.7-1.5-1.71.21.51.61.0
Reaction time trials completed0.10.10.3-0.3-0.6-0.20.4-0.50.40.30.4-0.2-0.4-0.4-0.1
Reaction time trials AUC0.40.60.9-0.7-0.9-0.60.8-0.80.80.70.8-0.6-0.8-0.8-0.5
Run reversals in cocaine runway, females0.30.30.80.90.60.5-0.40.4-0.4-0.4-0.40.80.20.20.5
Run reversals in cocaine runway, males0.50.50.80.80.90.7-0.80.8-0.8-0.7-0.60.30.80.70.4
Latency to leave start box in cocaine runway0.70.71.00.31.00.7-0.91.0-0.9-0.8-1.00.90.90.90.6
Latency to leave start box in cocaine runway, F0.20.30.5-0.20.40.3-0.60.6-0.6-0.5-0.70.60.70.60.4
Latency to leave start box in cocaine runway, M0.40.41.20.81.10.7-0.70.7-0.6-0.6-0.50.40.40.50.4
Std. dev. time between licks in bursts2.22.73.0-1.5-1.6-1.61.7-1.71.71.71.7-1.7-1.7-1.6-1.6
Total sessions with >9 infusions0.10.10.4-0.6-0.5-0.10.2-0.1-0.0-0.2-0.20.10.40.50.5
Short access day 1 total inactive lever presses0.10.10.20.30.20.1-0.10.1-0.1-0.2-0.10.50.30.40.3
Short access day 10 total inactive lever presses0.10.10.40.30.5-0.10.1-0.20.20.20.30.3-0.1-0.6-0.1
Short access day 1 total infusions1.51.62.8-1.7-1.4-1.31.3-1.21.21.11.1-1.5-1.0-0.9-1.0
Short access day 10 total infusions1.01.12.4-1.5-1.5-1.01.2-1.11.00.80.8-1.1-0.9-0.5-0.4
Short access total infusions1.11.22.3-1.5-1.4-1.01.2-1.11.00.91.0-1.4-0.9-0.6-0.7
Short access day 1 locomotion0.20.20.5-0.5-0.20.3-0.20.3-0.3-0.4-0.50.20.60.60.7
Short access day 10 total locomotion0.80.91.50.30.81.0-0.91.0-1.0-1.1-1.20.70.91.11.1
Short access total locomotion0.60.61.3-0.10.20.7-0.60.6-0.7-0.9-1.00.50.91.01.2
One hour access (0.3 mA shock)0.10.10.3-0.5-0.4-0.30.1-0.10.10.10.1-0.50.20.0-0.1
Compulsive drug intake9.29.311.73.42.73.1-3.13.1-3.0-3.0-3.13.12.92.93.1
One hour access (shock baseline)2.73.15.1-2.3-1.8-1.81.7-1.71.71.71.7-2.2-1.4-1.5-1.8
Social response proportion1.11.21.90.91.01.1-1.21.2-1.2-1.1-1.20.81.01.40.9
Social responses1.82.33.6-1.9-1.6-1.71.5-1.41.41.51.3-1.4-1.4-1.2-1.6
Social time0.40.60.80.60.80.6-0.90.9-0.9-0.7-0.80.80.70.90.5
Soleus weight0.00.10.20.2-0.2-0.10.2-0.30.30.20.5-0.1-0.2-0.4-0.0
Bone: stiffness5.28.29.1-3.0-3.0-2.92.9-2.92.92.92.7-2.8-2.7-2.8-2.8
Tibialis anterior weight0.30.91.30.90.70.9-0.80.8-0.9-1.0-0.91.11.01.01.1
Time to tail flick, vehicle, before self-admin4.14.25.42.12.12.1-2.02.0-2.0-2.0-1.92.32.21.82.1
Time to tail flick, vehicle, after self-admin2.62.83.61.91.81.8-1.81.8-1.7-1.7-1.60.91.71.61.5
Time to tail flick, test, before self-admin0.30.30.80.70.90.6-0.70.6-0.6-0.5-0.50.40.40.40.3
Time to tail flick, test, after self-admin0.10.10.80.90.70.2-0.10.1-0.0-0.10.00.3-0.2-0.20.1
Delta time to tail flick, vehicle, before/after SA1.01.02.7-0.6-0.8-0.80.8-0.80.80.91.0-1.6-1.0-0.9-1.2
Delta time to tail flick, test, before/after SA0.10.10.30.50.50.3-0.30.4-0.3-0.3-0.40.40.30.30.4
Tibia length7.120.127.4-5.2-5.2-4.74.6-4.54.44.33.9-4.4-4.0-4.1-4.2
Ambulatory time before self-admin5.75.97.4-2.5-2.6-2.62.7-2.72.62.52.3-1.4-2.6-2.5-2.1
Ambulatory time after self-admin2.12.33.0-1.7-1.5-1.61.6-1.51.51.51.3-1.2-1.7-1.4-1.4
Bone: tissue strength0.80.71.0-0.7-0.8-0.80.8-0.80.80.90.9-1.0-0.8-1.0-0.9
Total heroin consumption0.91.11.80.71.01.1-0.91.0-1.0-1.1-1.11.21.11.01.3
Bone: trabecular number0.10.10.3-0.4-0.5-0.30.3-0.30.30.30.3-0.5-0.3-0.2-0.5
Bone: trabecular spacing0.30.40.70.50.50.6-0.50.5-0.5-0.6-0.60.80.60.60.8
Bone: trabecular thickness1.31.61.9-1.3-1.4-1.21.2-1.21.21.21.2-1.4-1.2-1.2-1.3
Bone: trabecular tissue density0.60.81.1-0.9-1.0-1.00.9-0.90.90.90.8-0.8-0.7-0.8-0.9
Water consumed over 24 hours0.50.61.6-1.3-1.2-0.70.9-0.80.70.60.5-0.5-0.4-0.5-0.3
Number of responses in last shaping day1.71.82.7-1.7-1.2-1.41.3-1.31.31.31.3-1.6-1.3-1.0-1.3