Hub : Genes

LOC108350383

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 IC intron excision ratio chr3_68231297_68231717 0.13 0.09 1.0e-04 0.08 0.06 0.07 0.07 2.6e-04 1.2e-03 4.6e-04 6.4e-04
2 pVTA intron excision ratio chr3_68231369_68231717 0.03 0.03 3.1e-03 0.01 0.02 0 0.01 5.0e-02 6.5e-03 1.3e-01 8.0e-02
3 Brain intron excision ratio chr3_68231297_68231717 0.08 0.06 1.5e-07 0.06 0.08 0.08 0.08 3.3e-06 6.6e-08 1.2e-07 8.0e-08
4 Brain intron excision ratio chr3_68231369_68231717 0.04 0.03 2.1e-04 0.02 0.03 0.03 0.02 5.6e-03 1.2e-03 1.9e-03 3.2e-03
5 BLA intron excision ratio chr3_68231369_68231717 0.06 0.05 2.7e-03 0.03 0.03 0.03 0.02 1.2e-02 1.3e-02 7.0e-03 3.3e-02
6 PL gene expression LOC108350383 0.03 0.02 4.8e-04 0.02 0.03 0.02 0.02 1.3e-03 8.5e-04 4.5e-03 3.4e-03
7 IC intron excision ratio chr3_68231369_68231717 0.13 0.12 7.5e-04 0.03 0.05 0.04 0.04 2.7e-02 3.8e-03 7.7e-03 6.7e-03
8 OFC intron excision ratio chr3_68231297_68231717 0.13 0.09 7.3e-03 0.09 0.07 0.06 0.08 3.7e-03 8.8e-03 1.5e-02 6.4e-03
9 LHb gene expression LOC108350383 0.27 0.15 4.0e-05 0.14 0.16 0.17 0.17 4.4e-04 1.3e-04 8.3e-05 6.8e-05
10 NAcc intron excision ratio chr3_68231297_68231717 0.02 0.02 2.7e-04 0.03 0.03 0.03 0.02 8.8e-05 8.5e-05 7.3e-05 1.1e-04
11 BLA intron excision ratio chr3_68231297_68231717 0.1 0.06 2.8e-05 0.08 0.07 0.07 0.07 7.3e-05 9.1e-05 9.1e-05 8.7e-05
12 PL intron excision ratio chr3_68231369_68231717 0.04 0.03 4.5e-05 0.03 0.04 0.02 0.03 2.4e-04 7.7e-05 1.5e-03 3.2e-04
13 Brain gene expression LOC108350383 0.04 0.03 6.5e-04 0.05 0.03 0.02 0.04 2.7e-05 4.2e-04 5.7e-03 1.3e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13
Bone: apparent density0.30.62.4-0.8-0.40.6-0.61.50.5-0.6-0.40.2-0.6-1.6-0.6-0.0
Area under the delay curve0.10.20.40.30.6-0.40.4-0.2-0.40.40.4-0.60.40.20.30.5
BMI with tail0.00.10.4-0.6-0.50.3-0.10.20.1-0.5-0.10.1-0.20.00.1-0.1
BMI without tail0.21.31.8-1.3-1.31.2-1.10.91.1-1.4-1.21.1-1.2-0.9-1.0-1.1
Body weight0.31.44.5-2.1-1.51.3-1.11.10.9-1.3-0.90.9-0.9-0.8-0.7-0.9
Weight adjusted by age0.41.32.11.11.5-1.31.2-1.4-1.11.21.0-1.11.00.90.90.9
Bone surface1.02.03.7-1.5-1.31.5-1.41.91.4-1.3-1.21.1-1.3-1.9-1.4-0.9
Bone volume0.61.32.9-1.5-1.01.2-1.11.70.9-1.0-0.80.6-1.0-1.6-0.9-0.5
Breakpoint value in progressive ratio session4.78.510.72.32.9-2.92.9-3.0-3.03.03.0-2.93.13.32.92.7
Number of licking bursts0.00.00.2-0.1-0.10.1-0.1-0.30.2-0.1-0.20.1-0.10.4-0.2-0.2
Context. condit. distance diff. score0.00.10.4-0.3-0.00.1-0.10.40.00.00.0-0.1-0.1-0.6-0.10.0
Locomotion velocity, session 10.30.40.70.3-0.50.5-0.60.10.7-0.6-0.90.8-0.7-0.2-0.8-0.7
Locomotion distance, session 10.10.10.30.2-0.10.2-0.30.50.3-0.2-0.30.3-0.3-0.6-0.4-0.3
Locomotion velocity, session 21.62.02.81.21.7-1.51.4-1.1-1.41.51.5-1.51.41.11.21.6
Locomotion distance, session 20.10.20.8-0.9-0.40.5-0.50.60.3-0.3-0.20.3-0.3-0.3-0.4-0.2
Locomotion velocity, session 30.70.81.20.71.1-0.90.9-1.1-0.90.91.0-0.81.00.90.80.8
Locomotion distance, session 30.30.30.4-0.3-0.40.5-0.50.40.6-0.6-0.60.6-0.5-0.5-0.6-0.7
Stereotopy head waving bouts, day 30.30.41.5-1.2-0.80.7-0.60.70.4-0.5-0.40.4-0.4-0.6-0.3-0.4
Stereotopy head waving duration, day 30.10.10.6-0.8-0.30.4-0.30.50.1-0.1-0.00.1-0.1-0.5-0.1-0.1
Locomotion velocity, session 70.00.00.10.30.1-0.0-0.00.30.0-0.0-0.0-0.1-0.1-0.4-0.1-0.1
Locomotion distance, session 70.00.00.0-0.1-0.00.0-0.00.1-0.00.00.0-0.0-0.0-0.10.0-0.0
Stereotopy head waving bouts, day 70.10.20.4-0.6-0.40.4-0.40.50.4-0.4-0.40.3-0.3-0.4-0.3-0.4
Stereotopy head waving duration, day 70.30.30.5-0.7-0.60.6-0.60.70.5-0.5-0.50.5-0.5-0.7-0.6-0.5
Locomotion velocity, session 80.00.00.1-0.20.2-0.00.1-0.0-0.10.20.2-0.20.20.10.00.3
Locomotion distance, session 80.00.10.1-0.30.2-0.20.20.2-0.30.30.4-0.30.3-0.10.30.3
Degree of sensitization distance0.70.81.10.30.7-0.80.8-0.7-1.00.91.0-1.00.90.91.01.0
Degree of sensitization stereotypy0.00.00.0-0.10.1-0.10.1-0.0-0.10.00.1-0.10.10.10.10.0
Conditioned locomotion0.80.91.60.31.1-0.90.9-0.5-1.01.11.3-1.11.10.60.91.1
Cocaine response after cond. corrected5.98.811.71.82.8-2.93.0-3.0-3.13.03.1-3.13.23.43.12.9
Cocaine response after cond. not corrected3.75.37.60.82.1-2.02.2-2.3-2.42.42.5-2.52.62.82.52.4
Cocaine response before conditioning2.63.24.5-2.1-1.92.0-1.92.01.7-1.6-1.51.5-1.6-1.9-1.7-1.4
Saline control response0.20.30.50.30.5-0.50.5-0.7-0.50.50.5-0.50.60.70.50.5
Bone: connectivity density0.30.52.4-0.5-0.30.6-0.61.40.6-0.5-0.40.3-0.7-1.5-0.7-0.1
Bone: cortical apparent density0.30.51.4-0.6-0.50.6-0.61.10.5-0.6-0.50.5-0.6-1.2-0.6-0.6
Bone: cortical area4.37.09.7-3.1-2.92.8-2.72.72.5-2.6-2.52.4-2.5-2.6-2.3-2.4
Bone: cortical porosity2.32.53.7-1.9-1.71.7-1.61.81.5-1.6-1.51.4-1.5-1.6-1.5-1.3
Bone: cortical porosity4.75.25.9-2.3-2.42.4-2.32.42.3-2.4-2.32.1-2.3-2.2-2.2-2.0
Bone: cortical thickness3.35.56.9-2.6-2.62.4-2.32.62.2-2.4-2.32.1-2.3-2.5-2.0-2.1
Bone: cortical thickness6.17.48.8-2.8-3.02.8-2.72.92.6-2.8-2.62.6-2.7-3.0-2.4-2.6
Bone: cortical tissue density0.20.41.3-0.5-0.40.5-0.51.00.5-0.5-0.40.4-0.5-1.1-0.5-0.5
Condit. Reinf. active minus inactive responses6.77.69.1-2.9-2.82.9-2.73.02.7-2.9-2.62.6-2.7-3.0-2.6-2.6
Condit. Reinf. active-inactive response ratio2.72.94.2-1.5-1.71.7-1.61.91.6-1.8-1.61.6-1.7-2.0-1.6-1.6
Condit. Reinf. active responses5.16.68.1-2.6-2.52.6-2.62.82.5-2.6-2.42.4-2.5-2.9-2.6-2.4
Condit. Reinf. inactive responses1.41.82.1-1.4-1.31.4-1.41.31.4-1.2-1.41.3-1.3-1.3-1.4-1.3
Incentive salience index mean6.27.99.7-2.9-2.82.9-2.83.12.8-2.9-2.62.6-2.8-3.1-2.7-2.6
Condit. Reinf. lever presses0.91.32.3-1.1-1.01.0-1.11.41.1-1.1-1.11.0-1.2-1.5-1.1-1.0
Condit. Reinf. active minus inactive responses2.74.25.9-2.2-2.02.2-2.22.42.0-1.9-1.91.8-2.0-2.3-2.1-1.7
Condit. Reinf. active-inactive response ratio1.62.63.8-1.7-1.51.6-1.71.91.6-1.4-1.51.4-1.6-1.8-1.7-1.3
Condit. Reinf. active responses2.84.05.2-2.3-2.22.1-2.12.31.9-1.9-1.81.8-2.0-2.2-1.8-1.6
Condit. Reinf. inactive responses0.00.10.5-0.7-0.40.3-0.20.20.0-0.1-0.10.1-0.1-0.20.10.0
Condit. Reinf. lever presses2.94.38.3-2.9-2.12.3-2.22.31.9-1.8-1.81.6-1.9-2.1-2.0-1.6
Condit. Reinf. lever reinforcers received1.92.73.9-1.8-1.71.7-1.72.01.5-1.4-1.51.4-1.6-1.9-1.5-1.2
Conditioned reinforcement - actives0.52.03.1-1.8-1.71.5-1.41.21.4-1.5-1.11.6-1.4-0.9-1.2-1.5
Conditioned reinforcement - inactives0.10.10.90.0-0.30.0-0.1-0.50.1-0.0-0.20.4-0.10.90.0-0.6
Conditioned locomotion0.10.20.8-0.7-0.20.10.1-0.3-0.20.20.4-0.20.20.90.40.3
Patch foraging indifference point 0 sec0.00.10.4-0.6-0.30.10.0-0.4-0.0-0.2-0.10.2-0.10.40.20.1
Patch foraging indifference point AUC0.10.20.90.70.30.2-0.50.50.50.1-0.30.2-0.4-0.7-0.9-0.3
Delay disc. indifference point, 0s delay0.00.00.1-0.3-0.10.0-0.0-0.1-0.00.0-0.2-0.00.00.00.1-0.1
Delay disc. indifference point, 16s delay0.10.10.2-0.5-0.30.3-0.20.40.2-0.4-0.30.2-0.3-0.5-0.2-0.3
Delay disc. indifference point, 2s delay0.10.20.30.2-0.20.2-0.30.30.5-0.5-0.40.4-0.5-0.4-0.5-0.6
Delay disc. indifference point, 24s delay0.30.51.11.10.9-0.70.6-0.3-0.70.90.8-0.80.60.00.50.8
Delay disc. indifference point, 4s delay0.60.61.11.11.0-0.90.8-0.5-0.70.70.6-0.80.80.60.60.8
Delay disc. indifference point, 8s delay0.10.20.40.00.6-0.40.5-0.1-0.50.50.6-0.60.50.30.40.5
Indifference point function ln k0.10.30.5-0.7-0.70.3-0.2-0.20.3-0.7-0.70.7-0.40.4-0.1-0.6
Indifference point function log k0.10.30.5-0.7-0.70.3-0.2-0.20.3-0.7-0.70.7-0.40.4-0.1-0.6
Patch foraging total patch changes 0 sec0.10.20.7-0.30.1-0.30.4-0.8-0.30.10.1-0.10.20.80.50.4
Patch foraging total patch changes 12 sec1.21.62.6-1.6-1.21.5-1.40.91.3-1.2-1.31.1-1.2-0.8-1.4-1.1
Patch foraging total patch changes 18 sec0.61.52.3-1.5-1.21.4-1.41.11.3-1.1-1.21.1-1.2-0.9-1.4-0.9
Patch foraging total patch changes 24 sec0.41.22.4-1.5-1.21.3-1.21.01.1-1.0-1.10.9-1.0-0.9-1.1-0.7
Patch foraging total patch changes 6 sec0.10.20.30.50.5-0.40.4-0.5-0.40.50.6-0.50.40.40.40.4
Patch foraging time to switch 0 sec0.10.30.90.00.1-0.40.6-0.3-0.70.30.8-0.50.50.31.00.8
Patch foraging water rate 0 sec0.93.34.6-2.1-1.82.0-1.91.41.9-1.8-1.91.8-1.7-1.2-1.9-2.0
Patch foraging water rate 12 sec0.93.54.9-2.0-2.02.0-1.91.31.9-1.9-2.12.0-1.7-1.0-1.8-2.2
Patch foraging water rate 18 sec2.35.26.3-2.0-2.32.3-2.32.32.3-2.3-2.32.3-2.3-2.0-2.3-2.5
Patch foraging water rate 24 sec2.53.55.0-1.3-1.71.8-1.91.71.9-1.9-2.12.0-1.9-1.7-2.0-2.2
Patch foraging water rate 6 sec3.65.47.2-1.7-2.52.3-2.41.82.5-2.5-2.72.6-2.4-1.4-2.4-2.6
Seeking ratio, delayed vs. immediate footshock0.20.30.9-1.0-0.70.6-0.50.50.4-0.4-0.80.4-0.3-0.3-0.3-0.4
Distance traveled before self-admin1.63.55.6-2.1-2.42.0-1.91.21.8-1.9-2.21.9-1.8-1.2-1.5-1.9
Distance traveled after self-admin1.52.73.6-1.9-1.91.7-1.61.61.5-1.6-1.81.4-1.7-1.7-1.4-1.5
Extensor digitorum longus weight0.20.71.1-1.0-1.10.9-0.90.60.8-0.8-0.90.9-0.8-0.4-0.7-1.0
Bone: elastic displacement0.10.10.40.50.2-0.40.4-0.6-0.30.10.1-0.10.20.40.40.0
Bone: elastic work0.00.00.00.2-0.2-0.00.00.00.1-0.2-0.20.2-0.2-0.10.0-0.2
Bone: endosteal estimation0.41.01.3-1.1-0.91.1-1.11.11.0-0.9-0.80.9-0.8-0.9-1.1-0.9
Bone: endosteal perimeter0.61.52.0-1.0-1.21.3-1.41.21.3-1.1-1.11.2-1.1-1.1-1.4-1.1
Epididymis fat weight5.427.330.95.55.5-5.65.5-5.2-5.25.05.1-5.05.05.05.15.2
Delta time in closed arm before/after self-admin1.51.41.70.71.2-1.11.2-1.1-1.31.21.2-1.31.31.01.21.3
Delta time in open arm before/after self-admin1.61.92.8-0.8-1.41.3-1.31.21.4-1.4-1.51.4-1.7-1.6-1.4-1.2
Diff in mean of infusions in LGA sessions7.713.916.83.03.9-3.83.9-3.3-3.93.74.1-4.03.93.13.83.9
Delay discount exponential model param0.20.30.5-0.6-0.70.6-0.50.30.5-0.5-0.50.6-0.5-0.3-0.4-0.6
Extinction: sum of active levers before priming0.30.41.9-0.70.1-0.20.4-1.1-0.50.40.5-0.40.81.40.6-0.0
Active lever presses in extinction session 60.20.21.8-1.3-0.50.3-0.1-0.3-0.1-0.20.10.10.10.30.3-0.2
Bone: final force4.37.09.5-2.1-2.72.6-2.73.02.6-2.6-2.62.5-2.8-3.1-2.6-2.4
Bone: final moment4.26.78.9-2.0-2.62.6-2.62.92.6-2.6-2.62.5-2.7-3.0-2.5-2.4
Food consumed during 24 hour testing period0.30.63.3-1.8-0.81.0-0.80.50.6-0.6-0.50.4-0.4-0.2-0.6-0.5
Glucose0.40.61.8-1.3-0.90.8-0.70.60.7-0.7-0.80.8-0.7-0.4-0.6-0.7
Heart weight0.30.50.7-0.2-0.70.6-0.60.50.8-0.8-0.80.8-0.8-0.5-0.7-0.8
Delay discount hyperbolic model param0.20.20.5-0.6-0.70.5-0.50.20.5-0.5-0.50.6-0.4-0.3-0.3-0.5
Intermittent access intake day 1-15 change1.15.88.4-1.9-2.62.4-2.41.82.5-2.6-2.72.9-2.5-1.8-2.3-2.5
Intermittent access intake escalation1.05.37.7-1.8-2.52.3-2.31.72.4-2.4-2.62.8-2.4-1.8-2.3-2.4
Intermittent access intake escalation 22.33.96.2-1.3-2.01.9-1.91.52.1-2.1-2.32.5-2.1-1.6-2.0-2.1
Intermitt. access day 1 inactive lever presses0.22.23.51.91.4-1.61.5-1.7-1.41.51.4-1.31.41.61.41.2
Intermitt. access day 15 inactive lever presses0.00.20.80.90.3-0.40.3-0.4-0.30.40.0-0.10.20.50.30.3
Intermitt. access escalation Index0.10.41.30.1-0.30.4-0.51.00.6-0.7-0.60.5-0.8-1.1-0.7-0.4
Intermittent access day 1 total infusions0.10.30.5-0.20.4-0.40.5-0.3-0.60.50.7-0.70.70.60.70.4
Intermittent access day 15 total infusions0.71.82.6-1.6-1.51.5-1.41.01.3-1.3-1.31.5-1.2-0.9-1.2-1.4
Intermittent access terminal intake (last 3 days)1.52.63.2-1.8-1.81.7-1.61.31.6-1.6-1.61.8-1.5-1.2-1.5-1.7
Intermittent access total infusions0.50.61.7-1.3-0.90.9-0.80.60.7-0.7-0.60.8-0.5-0.4-0.6-0.8
Intermittent access day 1 locomotion1.62.94.00.91.4-1.61.7-1.7-1.81.81.9-1.81.82.01.91.7
Intermittent access day 15 total locomotion0.00.20.7-0.9-0.70.6-0.50.10.3-0.2-0.10.4-0.30.2-0.2-0.3
Intermittent access total locomotion0.10.10.4-0.6-0.20.10.0-0.2-0.10.10.2-0.10.10.40.30.0
Intermittent access standard deviation0.42.23.6-1.8-1.91.6-1.50.91.5-1.4-1.71.7-1.4-0.8-1.2-1.4
Left kidney weight0.21.72.9-1.7-1.41.5-1.51.01.4-1.2-1.41.2-1.2-0.6-1.4-1.2
Right kidney weight0.74.65.5-2.2-2.32.3-2.31.92.2-2.2-2.32.1-2.1-1.7-2.1-2.2
Cocaine induced anxiety0.10.41.21.10.9-0.90.8-0.2-0.60.50.6-0.50.50.20.50.4
Post-drug Anxiety0.40.51.0-0.2-0.70.6-0.60.80.7-0.8-1.00.9-0.8-0.5-0.7-0.7
Baseline Anxiety1.32.23.8-1.7-1.91.7-1.61.01.5-1.4-1.71.4-1.5-0.8-1.2-1.3
Tail length0.84.35.9-2.4-2.12.4-2.32.02.1-1.9-2.01.9-1.9-1.8-2.2-1.9
Length with tail0.73.05.9-2.4-1.92.0-1.91.71.7-1.6-1.51.6-1.5-1.5-1.6-1.5
Length without tail0.52.83.6-1.9-1.91.7-1.71.91.6-1.7-1.41.6-1.6-1.7-1.4-1.5
Times rat made contact with spout4.65.36.61.12.3-2.12.3-2.3-2.42.32.4-2.42.42.62.32.5
Lifetime Intake0.50.62.6-1.6-0.90.9-0.70.60.6-0.7-0.50.6-0.4-0.4-0.5-0.7
Liver weight, left0.50.81.3-1.1-1.11.0-0.90.80.8-0.9-0.70.9-0.9-0.8-0.7-0.9
Liver weight, right0.10.10.4-0.4-0.1-0.10.2-0.6-0.40.30.2-0.30.40.70.50.3
Locomotor activity2.64.15.1-2.1-2.22.3-2.22.12.0-1.9-1.81.9-1.9-1.9-2.0-1.7
Locomotor testing distance3.89.210.5-2.9-3.23.2-3.23.03.1-3.0-2.93.1-3.0-2.9-3.0-2.9
Locomotor testing rearing2.79.711.0-2.7-3.33.3-3.23.13.1-3.0-3.13.2-3.1-3.1-3.0-3.1
Locomotion in novel chamber1.21.62.8-0.41.0-0.91.1-0.8-1.41.31.4-1.61.31.21.41.7
Locomotion in novel chamber post-restriction0.41.32.5-0.9-1.20.9-0.91.40.9-1.2-1.21.1-1.2-1.6-0.8-1.1
Fecal boli incidents, locomotor time 10.10.31.91.40.0-0.30.0-0.10.3-0.3-0.50.5-0.5-0.5-0.3-0.5
Change in fecal boli incidents, locomotor task0.10.10.9-0.9-0.30.3-0.20.20.00.10.10.00.1-0.00.00.1
Time >=10cm from walls, locomotor time 10.40.50.7-0.6-0.80.7-0.70.80.6-0.7-0.70.7-0.7-0.8-0.6-0.6
Bouts of movement, locomotor time 12.12.85.72.41.8-1.91.8-1.8-1.61.51.0-1.51.51.41.61.6
Total resting periods, locomotor time 11.92.25.32.31.6-1.71.7-1.6-1.41.30.9-1.31.31.21.41.4
Rest time, locomotor task time 11.42.34.22.01.7-1.71.6-1.5-1.41.41.2-1.51.31.31.41.4
Distance moved, locomotor task time 11.23.45.8-2.4-2.02.0-1.81.81.7-1.9-1.51.8-1.6-1.9-1.6-1.7
Vertical activity count, locomotor time 10.10.61.1-1.1-0.80.8-0.70.70.7-0.9-0.50.9-0.6-0.7-0.7-0.8
Time >=10cm from walls, locomotor time 20.00.10.4-0.7-0.30.4-0.30.10.10.00.10.10.10.2-0.10.1
Bouts of movement, locomotor time 20.51.52.91.71.1-1.41.5-1.5-1.30.90.6-1.01.01.41.41.0
Total resting periods, locomotor time 20.41.63.61.91.2-1.51.5-1.5-1.30.90.6-1.01.01.31.41.1
Rest time, locomotor task time 20.30.62.01.40.8-0.90.9-0.9-0.70.50.4-0.60.50.60.70.5
Distance moved, locomotor task time 20.81.03.0-1.7-1.11.2-1.10.90.9-0.9-0.70.9-0.7-1.0-0.8-0.8
Vertical activity count, locomotor time 20.00.00.3-0.10.2-0.10.2-0.2-0.10.10.5-0.10.20.00.10.1
Light reinforcement 10.10.40.8-0.1-0.60.6-0.70.20.8-0.7-0.90.7-0.8-0.3-0.8-0.7
Light reinforcement 20.20.51.20.5-0.20.5-0.60.70.8-0.7-0.80.6-0.8-0.9-1.1-0.6
Bone: marrow area0.41.11.4-1.2-1.01.2-1.21.21.1-0.9-0.80.9-0.8-1.0-1.2-1.0
Bone: maximum diameter1.42.85.8-2.4-1.91.9-1.81.61.6-1.6-1.41.5-1.4-1.3-1.5-1.6
Bone: maximum force3.87.49.4-2.4-2.82.7-2.73.02.7-2.7-2.72.6-2.8-3.1-2.6-2.5
Bone: maximum moment3.87.28.8-2.4-2.82.7-2.72.92.7-2.7-2.72.7-2.7-3.0-2.6-2.5
Mean time between licks in bursts0.00.10.4-0.6-0.20.3-0.3-0.10.2-0.0-0.2-0.1-0.10.3-0.2-0.1
Mean num. licks in bursts0.71.92.60.61.4-1.31.4-1.0-1.51.41.6-1.51.51.11.51.6
Cd content in liver0.10.10.20.30.3-0.30.3-0.2-0.30.20.3-0.20.30.40.30.2
Co content in liver0.10.10.8-0.9-0.20.3-0.20.40.00.10.1-0.10.1-0.20.00.1
Cu content in liver0.50.61.20.3-0.40.6-0.81.00.9-0.7-0.80.8-0.9-0.9-1.1-0.8
Fe content in liver0.10.11.41.20.3-0.40.2-0.1-0.00.0-0.10.2-0.1-0.0-0.0-0.2
K content in liver0.50.51.1-0.4-0.60.8-0.90.50.9-0.6-0.80.7-0.7-0.5-1.0-0.7
Mg content in liver1.21.31.9-0.8-1.11.2-1.30.71.3-1.1-1.31.2-1.2-0.7-1.4-1.2
Mn content in liver10.011.212.7-2.8-3.23.5-3.53.53.5-3.4-3.33.3-3.4-3.3-3.6-3.3
Na content in liver4.04.55.4-1.6-2.22.2-2.31.82.3-2.1-2.32.3-2.2-1.7-2.3-2.3
Rb content in liver1.11.31.5-1.0-1.21.2-1.21.11.2-1.1-1.11.1-1.2-1.1-1.2-1.1
Se content in liver0.70.91.11.01.0-1.01.0-1.0-0.90.90.9-0.80.90.90.90.8
Sr content in liver0.50.40.7-0.8-0.60.7-0.60.70.6-0.6-0.60.6-0.6-0.6-0.5-0.6
Zn content in liver0.40.41.3-0.00.4-0.50.6-0.9-0.70.70.6-0.60.71.10.80.6
Bone: minimum diameter0.81.52.0-1.4-1.41.3-1.31.41.2-1.2-1.11.1-1.1-1.2-1.1-1.0
Time in familiar zone, hab. session 10.10.10.30.20.5-0.20.2-0.3-0.20.60.5-0.50.40.30.10.5
Time in novel zone, hab. session 10.30.40.60.70.4-0.70.7-0.7-0.60.40.5-0.50.50.60.80.5
Total zone transitions, hab. session 11.52.02.7-1.5-1.41.5-1.51.61.4-1.3-1.31.3-1.4-1.6-1.4-1.3
Total locomotion distance, hab. session 11.42.02.6-1.0-1.31.5-1.61.51.5-1.2-1.41.4-1.4-1.5-1.6-1.5
Locomotion velocity, hab. session 11.31.82.2-0.9-1.21.4-1.51.41.4-1.2-1.31.4-1.3-1.4-1.5-1.4
Time in familiar zone, hab. session 22.22.53.01.51.7-1.61.6-1.4-1.61.71.7-1.61.61.31.61.6
Time in novel zone, hab. session 21.51.62.3-1.5-1.41.3-1.31.11.2-1.4-1.41.3-1.2-0.9-1.1-1.3
Total zone transitions, hab. session 21.01.31.6-1.1-1.31.2-1.21.21.1-1.1-1.11.1-1.1-1.0-1.0-1.0
Total locomotion distance, hab. session 20.60.81.0-0.4-0.90.9-0.90.80.9-1.0-1.01.0-0.9-0.8-0.9-1.0
Locomotion velocity, hab. session 20.40.60.8-0.2-0.80.7-0.80.60.8-0.8-0.90.9-0.8-0.7-0.8-0.9
Novel to familiar place preference ratio0.60.71.20.10.6-0.80.9-0.8-1.00.81.0-0.90.91.01.10.9
Novelty place preference0.70.91.30.10.6-0.80.9-0.9-1.00.91.0-1.01.01.11.20.9
Time in novel zone, NPP test0.70.81.40.10.6-0.80.9-0.9-1.00.91.0-0.91.01.11.20.9
Total zone transitions, NPP test0.10.20.5-0.3-0.30.4-0.40.70.4-0.2-0.30.3-0.4-0.7-0.4-0.3
Total locomotion distance, NPP test0.81.11.6-0.6-0.91.0-1.11.21.1-1.0-1.01.0-1.1-1.3-1.2-1.0
Locomotion velocity, NPP test0.91.21.7-0.6-0.91.1-1.21.21.2-1.0-1.11.1-1.1-1.3-1.3-1.1
Intraocular pressure1.22.02.5-1.6-1.51.5-1.41.41.4-1.5-1.21.3-1.4-1.3-1.4-1.4
Delta distance traveled before/after self-admin0.50.50.90.70.9-0.80.8-0.3-0.70.70.7-0.90.60.20.60.8
Delta ambulatory time before/after self-admin0.10.20.7-0.3-0.30.4-0.40.80.4-0.4-0.40.2-0.5-0.8-0.5-0.3
Parametrial fat weight2.86.67.82.72.7-2.82.7-2.7-2.62.72.4-2.32.52.62.52.1
Pavlov. Cond. lever latency0.40.51.31.10.8-0.70.6-0.8-0.60.60.6-0.50.60.60.50.5
Pavlov. Cond. magazine entry latency0.00.00.1-0.3-0.30.3-0.20.30.1-0.2-0.20.1-0.2-0.1-0.0-0.1
Pavlov. Cond. change in total contacts1.41.62.3-1.2-1.21.2-1.31.51.2-1.2-1.31.1-1.3-1.3-1.2-1.1
Pavlov. Cond. index score0.50.71.2-1.1-0.90.8-0.81.00.7-0.8-0.80.7-0.8-0.7-0.6-0.6
Pavlov. Cond. latency score0.40.61.3-1.1-0.90.8-0.70.90.6-0.7-0.70.5-0.7-0.7-0.6-0.5
Pavlov. Cond. lever contacts0.81.02.2-1.5-1.11.0-1.01.10.9-0.9-0.90.8-0.9-0.8-0.8-0.8
Pavlov. Cond. magazine entry number0.40.50.70.60.7-0.70.7-0.8-0.70.70.8-0.60.70.70.60.6
Pavlov. Cond. intertrial magazine entries0.91.12.3-1.5-1.11.2-1.11.01.0-1.0-0.80.9-0.8-0.9-1.0-0.9
Pavlov. Cond. lever-magazine prob. diff.0.60.71.2-1.1-1.00.9-0.81.00.8-0.8-0.80.7-0.8-0.8-0.7-0.7
Pavlov. Cond. response bias0.40.60.8-0.7-0.80.7-0.70.90.7-0.7-0.80.7-0.8-0.7-0.7-0.7
Pavlov. Cond. lever latency1.62.37.82.81.6-1.81.6-1.8-1.21.21.0-1.01.11.41.20.9
Pavlov. Cond. magazine entry latency1.11.62.7-0.90.9-0.71.0-0.9-1.31.31.6-1.41.51.41.31.6
Pavlov. Cond. change in total contacts0.30.82.9-1.7-0.81.1-1.01.00.8-0.5-0.50.6-0.6-0.7-0.9-0.3
Pavlov. Cond. index score0.20.43.2-1.8-0.10.3-0.10.1-0.30.40.6-0.50.50.40.30.7
Pavlov. Cond. latency score0.30.52.3-1.50.20.00.2-0.2-0.50.70.9-0.70.70.60.51.0
Pavlov. Cond. lever contacts1.42.17.8-2.8-1.51.7-1.51.81.2-1.1-0.90.9-1.1-1.4-1.2-0.8
Pavlov. Cond. magazine entry number1.31.72.80.5-1.10.9-1.11.01.4-1.5-1.61.5-1.6-1.4-1.3-1.7
Pavlov. Cond. intertrial magazine entries1.43.23.9-0.8-1.81.6-1.71.71.8-1.9-2.01.9-1.9-1.9-1.7-1.9
Pavlov. Cond. lever-magazine prob. diff.0.30.42.5-1.60.10.20.0-0.1-0.40.50.7-0.60.60.50.40.8
Pavlov. Cond. response bias0.71.05.8-2.4-1.01.2-1.01.10.6-0.5-0.30.4-0.4-0.7-0.5-0.2
Time in closed arm before self-admin0.00.00.00.20.1-0.0-0.00.1-0.00.1-0.2-0.2-0.1-0.1-0.00.0
Time in closed arm after self-admin0.30.30.70.30.6-0.50.5-0.4-0.60.70.5-0.80.60.50.60.6
Time in open arm before self-admin3.54.35.31.62.1-2.12.0-1.8-2.12.32.3-2.12.32.02.02.2
Time in open arm after self-admin0.10.10.20.10.2-0.30.3-0.4-0.30.30.4-0.20.30.20.40.5
Bone: periosteal estimation2.25.37.2-2.7-2.52.5-2.42.42.3-2.3-2.12.1-2.1-2.1-2.2-2.2
Bone: periosteal perimeter1.93.84.7-2.2-2.22.1-2.11.92.0-1.9-1.91.9-1.9-1.8-1.9-1.8
Bone: post-yield work0.71.21.7-0.7-1.11.0-1.11.11.2-1.1-1.11.3-1.1-1.1-1.1-1.2
Progressive ratio test 1 active lever presses0.91.63.3-1.8-1.61.4-1.20.91.1-1.3-1.21.3-1.1-0.7-0.9-1.4
Progressive ratio test 1 breakpoint0.91.53.1-1.7-1.61.4-1.20.91.1-1.3-1.21.3-1.0-0.6-0.9-1.4
Progressive ratio test 1 inactive lever presses0.00.00.2-0.5-0.30.2-0.1-0.10.0-0.1-0.00.0-0.10.40.1-0.2
Progressive ratio test 2 active lever presses0.60.81.3-1.1-0.91.0-1.00.90.9-0.7-0.90.7-0.9-0.6-0.9-0.9
Progressive ratio test 2 breakpoint0.70.91.3-1.1-1.01.1-1.10.90.9-0.7-0.90.8-0.9-0.6-1.0-0.9
Progressive ratio test 2 inactive lever presses0.20.71.0-0.7-0.90.9-1.00.80.9-0.7-1.00.8-0.9-0.4-1.0-0.9
Incentive Sensitization - Responses0.10.40.7-0.6-0.50.7-0.70.80.7-0.4-0.50.5-0.6-0.7-0.8-0.5
Incentive Sensitization - Breakpoint0.20.40.7-0.5-0.50.7-0.80.80.7-0.4-0.50.5-0.7-0.7-0.8-0.5
Sum of active levers in priming session hrs 5-63.53.35.71.21.7-1.71.9-2.0-1.81.61.8-1.81.92.41.91.6
Progressive ratio0.30.92.3-1.5-1.31.0-0.80.70.7-1.1-0.70.9-0.8-0.7-0.4-0.9
Food seeking constrained by brief footshock0.20.30.5-0.7-0.40.5-0.40.70.5-0.7-0.40.3-0.5-0.5-0.6-0.5
Seeking ratio, punishment vs. effort0.10.30.70.60.8-0.60.5-0.5-0.50.60.4-0.70.50.60.30.6
Retroperitoneal fat weight4.017.920.64.44.5-4.54.4-4.3-4.24.34.2-4.14.14.04.13.9
Reaction time number correct0.10.20.5-0.7-0.60.5-0.40.10.3-0.5-0.60.5-0.4-0.0-0.2-0.5
Reaction time mean minus median0.32.13.31.21.8-1.41.4-1.1-1.41.61.7-1.71.50.91.11.7
Reaction time mean minus median AUC0.64.05.71.62.4-2.01.9-1.9-1.92.22.3-2.22.11.51.62.2
Reaction time num false alarms1.42.43.3-1.6-1.51.8-1.81.51.7-1.3-1.71.5-1.4-1.3-1.8-1.2
Reaction time num false alarms AUC1.43.14.3-2.1-1.82.1-2.01.71.9-1.6-1.71.7-1.5-1.5-1.9-1.3
Reaction time trials correct on left0.10.20.5-0.7-0.60.5-0.40.10.3-0.5-0.60.5-0.4-0.0-0.2-0.5
Reaction time trials on left0.10.20.5-0.7-0.60.5-0.40.10.3-0.5-0.60.5-0.4-0.1-0.2-0.5
Reaction time mean1.22.64.82.22.2-1.81.6-1.1-1.51.71.7-1.71.40.61.11.8
Reaction time mean AUC1.53.56.02.32.5-2.11.9-1.3-1.81.92.0-1.91.70.81.42.1
Median of all reaction times1.11.74.02.01.8-1.51.3-0.8-1.11.31.2-1.31.00.30.81.4
Reaction time omissions0.91.52.21.21.5-1.21.2-1.2-1.11.31.2-1.31.10.80.91.5
Reaction time false alarm rate1.11.52.2-1.4-1.11.4-1.51.31.3-1.0-1.21.1-1.0-1.1-1.5-0.7
Reaction time premature initiation rate0.30.51.01.00.8-0.70.6-0.5-0.60.80.6-0.90.60.80.51.0
Reaction time premature initiations0.10.20.40.50.4-0.30.3-0.3-0.30.50.2-0.50.30.50.30.6
Std. dev. reaction times0.72.33.81.41.9-1.51.4-1.2-1.41.71.7-1.71.50.91.11.9
Reaction time trials completed0.10.20.5-0.7-0.60.5-0.40.10.3-0.5-0.60.5-0.4-0.1-0.2-0.5
Reaction time trials AUC0.20.71.0-1.0-1.00.9-0.70.50.7-0.9-1.00.9-0.8-0.5-0.6-0.9
Run reversals in cocaine runway, females0.10.20.50.60.2-0.40.3-0.7-0.20.3-0.4-0.00.10.60.30.3
Run reversals in cocaine runway, males0.20.20.50.40.7-0.50.40.1-0.40.40.5-0.60.5-0.10.20.6
Latency to leave start box in cocaine runway0.50.71.30.70.9-0.80.7-0.4-0.81.01.0-0.71.11.10.70.9
Latency to leave start box in cocaine runway, F0.40.50.90.40.7-0.60.5-0.4-0.70.90.9-0.60.90.90.60.9
Latency to leave start box in cocaine runway, M0.70.71.01.01.0-0.90.9-0.6-0.70.70.9-0.60.90.90.60.6
Std. dev. time between licks in bursts1.22.32.7-1.4-1.61.6-1.61.31.6-1.6-1.61.4-1.6-1.2-1.6-1.6
Total sessions with >9 infusions0.20.21.4-1.2-0.70.5-0.30.10.1-0.2-0.20.20.00.20.1-0.2
Short access day 1 total inactive lever presses0.61.22.70.70.9-0.91.0-1.4-1.01.10.8-1.01.11.61.11.0
Short access day 10 total inactive lever presses0.21.23.01.31.1-1.11.0-1.7-0.91.00.5-0.70.81.70.80.7
Short access day 1 total infusions0.20.41.5-1.2-0.70.8-0.60.40.5-0.6-0.50.3-0.4-0.3-0.4-0.4
Short access day 10 total infusions0.40.73.2-1.8-1.11.0-0.70.60.5-0.7-0.70.5-0.4-0.3-0.3-0.7
Short access total infusions0.10.21.8-1.3-0.50.4-0.20.10.0-0.1-0.2-0.10.10.10.2-0.1
Short access day 1 locomotion0.20.30.7-0.30.1-0.20.4-0.7-0.60.50.4-0.50.60.80.70.5
Short access day 10 total locomotion0.10.20.5-0.20.3-0.40.5-0.3-0.60.40.7-0.50.50.50.70.6
Short access total locomotion0.20.40.8-0.50.1-0.30.5-0.4-0.70.50.6-0.60.70.80.90.7
One hour access (0.3 mA shock)1.31.62.6-1.6-1.31.4-1.31.41.2-1.1-0.81.4-1.1-1.0-1.1-1.5
Compulsive drug intake6.79.911.33.23.2-3.33.3-2.8-3.33.43.3-3.23.02.53.23.1
One hour access (shock baseline)2.77.19.1-3.0-2.72.8-2.72.62.7-2.7-2.42.7-2.5-2.2-2.6-2.7
Social response proportion0.81.12.40.61.3-1.01.1-0.6-1.01.01.0-1.50.90.60.91.4
Social responses1.62.13.3-1.5-1.31.6-1.61.81.5-1.3-1.21.1-1.5-1.6-1.6-1.3
Social time0.40.71.11.01.0-0.80.7-0.7-0.81.00.9-0.90.80.60.60.7
Soleus weight0.00.00.1-0.1-0.2-0.00.0-0.40.0-0.0-0.20.2-0.00.40.1-0.2
Bone: stiffness5.09.111.2-2.9-3.13.1-3.13.33.0-3.0-2.92.9-3.0-3.3-2.9-2.8
Tibialis anterior weight0.20.81.10.40.7-0.90.9-1.0-1.00.90.8-0.90.91.01.00.9
Time to tail flick, vehicle, before self-admin2.02.53.21.21.5-1.61.6-1.5-1.61.71.2-1.71.61.81.71.5
Time to tail flick, vehicle, after self-admin2.14.25.62.42.3-2.32.2-2.1-2.12.01.7-2.11.91.32.02.0
Time to tail flick, test, before self-admin0.10.10.80.90.4-0.30.2-0.1-0.10.00.40.0-0.00.1-0.10.0
Time to tail flick, test, after self-admin0.30.31.50.80.3-0.50.5-1.2-0.40.40.5-0.20.40.90.40.1
Delta time to tail flick, vehicle, before/after SA0.70.72.3-0.1-0.50.6-0.70.70.8-1.0-0.90.9-0.9-1.5-0.9-0.8
Delta time to tail flick, test, before/after SA0.70.91.60.50.7-0.80.8-1.3-0.91.00.9-0.91.11.20.90.8
Tibia length6.919.124.8-5.0-4.54.7-4.64.94.2-4.3-3.84.0-4.0-4.4-4.1-4.0
Ambulatory time before self-admin1.03.15.1-2.1-2.22.0-1.81.21.7-1.8-1.91.8-1.6-1.0-1.5-1.8
Ambulatory time after self-admin0.81.32.1-1.4-1.41.3-1.21.11.1-1.1-1.20.9-1.1-0.9-1.0-1.0
Bone: tissue strength0.50.60.8-0.5-0.70.8-0.80.80.8-0.7-0.80.8-0.8-0.7-0.9-0.7
Total heroin consumption2.02.43.70.71.2-1.41.6-1.8-1.61.41.5-1.51.61.91.81.5
Bone: trabecular number0.30.52.7-0.2-0.30.4-0.41.40.4-0.5-0.40.2-0.7-1.6-0.5-0.1
Bone: trabecular spacing0.40.61.90.20.5-0.50.6-1.2-0.70.60.6-0.70.81.40.70.5
Bone: trabecular thickness1.21.72.8-1.1-1.21.3-1.31.61.2-1.3-1.21.2-1.2-1.7-1.3-1.1
Bone: trabecular tissue density0.50.81.4-1.1-0.91.0-1.01.20.8-0.7-0.70.8-0.8-1.1-0.9-0.8
Water consumed over 24 hours0.30.63.1-1.7-1.00.9-0.70.60.5-0.7-0.50.5-0.5-0.2-0.3-0.4
Number of responses in last shaping day1.01.31.6-1.2-1.21.2-1.10.91.2-1.2-1.21.2-1.2-1.0-1.1-1.0