Hub : Genes

LOC108349981

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC108349981 0.37 0.14 0.0e+00 0.22 0.22 0.22 0.22 6.9e-24 7.2e-24 1.9e-23 1.0e-23
2 pVTA gene expression LOC108349981 0.09 0.07 4.8e-03 0.04 0.04 0.04 0.04 1.0e-02 1.2e-02 1.0e-02 1.2e-02
3 Eye gene expression LOC108349981 0.76 0.11 1.8e-09 0.38 0.3 0.25 0.32 5.8e-07 1.9e-05 1.0e-04 8.4e-06
4 BLA gene expression LOC108349981 0.14 0.08 2.8e-05 0.04 0.05 0.05 0.05 2.0e-03 9.0e-04 1.1e-03 1.1e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density1.42.33.0-1.71.31.3-1.7
Area under the delay curve1.92.02.21.4-1.4-1.41.5
BMI with tail1.34.34.92.2-2.2-2.01.9
BMI without tail6.112.513.23.6-3.6-3.53.5
Body weight0.41.62.21.5-1.3-1.11.2
Weight adjusted by age0.30.30.3-0.50.60.60.5
Bone surface1.52.73.4-1.71.61.4-1.8
Bone volume2.13.64.4-2.11.71.6-2.1
Breakpoint value in progressive ratio session0.10.10.20.4-0.4-0.3-0.0
Number of licking bursts0.20.30.30.5-0.5-0.50.5
Context. condit. distance diff. score0.40.50.80.5-0.9-0.60.7
Locomotion velocity, session 10.20.20.40.4-0.6-0.50.3
Locomotion distance, session 10.10.10.4-0.1-0.1-0.0-0.6
Locomotion velocity, session 20.60.71.10.8-1.0-1.00.3
Locomotion distance, session 20.50.61.7-0.60.60.4-1.3
Locomotion velocity, session 30.00.00.0-0.2-0.2-0.10.0
Locomotion distance, session 30.80.91.3-1.00.70.9-1.2
Stereotopy head waving bouts, day 30.10.10.2-0.40.40.2-0.3
Stereotopy head waving duration, day 30.80.91.10.9-0.8-1.01.1
Locomotion velocity, session 717.719.421.9-4.54.14.2-4.7
Locomotion distance, session 77.08.99.3-3.02.92.9-3.0
Stereotopy head waving bouts, day 70.30.30.50.7-0.6-0.70.3
Stereotopy head waving duration, day 71.31.51.71.3-1.3-1.31.1
Locomotion velocity, session 81.21.42.21.1-1.5-1.30.7
Locomotion distance, session 80.10.10.30.1-0.5-0.3-0.2
Degree of sensitization distance1.21.21.3-1.11.11.1-1.0
Degree of sensitization stereotypy2.22.42.71.6-1.6-1.61.3
Conditioned locomotion0.50.60.8-0.80.80.6-0.9
Cocaine response after cond. corrected0.40.50.6-0.70.60.8-0.6
Cocaine response after cond. not corrected2.02.22.6-1.61.41.6-1.3
Cocaine response before conditioning1.51.82.3-1.51.31.4-1.2
Saline control response1.82.32.5-1.61.51.4-1.6
Bone: connectivity density1.72.63.1-1.81.61.5-1.7
Bone: cortical apparent density0.10.10.20.3-0.2-0.10.4
Bone: cortical area0.71.01.31.0-1.0-1.10.9
Bone: cortical porosity0.00.00.10.10.0-0.10.3
Bone: cortical porosity0.00.00.0-0.10.20.10.1
Bone: cortical thickness0.40.70.80.9-0.8-0.90.8
Bone: cortical thickness4.55.25.82.3-2.3-2.42.2
Bone: cortical tissue density0.10.10.20.4-0.2-0.10.4
Condit. Reinf. active minus inactive responses0.91.12.0-0.80.90.9-1.4
Condit. Reinf. active-inactive response ratio1.71.93.4-1.11.11.2-1.8
Condit. Reinf. active responses0.81.01.9-0.80.80.9-1.4
Condit. Reinf. inactive responses0.20.30.40.4-0.6-0.50.4
Incentive salience index mean0.50.61.3-0.50.60.7-1.1
Condit. Reinf. lever presses0.00.00.10.3-0.1-0.1-0.3
Condit. Reinf. active minus inactive responses3.44.24.5-1.92.12.1-2.1
Condit. Reinf. active-inactive response ratio1.51.62.2-1.11.21.2-1.5
Condit. Reinf. active responses6.18.59.0-2.82.93.0-2.9
Condit. Reinf. inactive responses1.92.42.6-1.51.61.6-1.5
Condit. Reinf. lever presses1.41.82.1-1.31.41.3-1.4
Condit. Reinf. lever reinforcers received5.57.78.0-2.72.82.8-2.8
Conditioned reinforcement - actives3.93.94.9-2.12.22.1-1.4
Conditioned reinforcement - inactives1.92.22.7-1.61.61.5-1.0
Conditioned locomotion0.60.71.0-0.91.00.8-0.6
Patch foraging indifference point 0 sec0.20.30.4-0.60.70.5-0.5
Patch foraging indifference point AUC0.20.20.4-0.70.20.5-0.2
Delay disc. indifference point, 0s delay0.30.30.70.5-0.3-0.40.9
Delay disc. indifference point, 16s delay0.90.91.01.0-1.0-1.00.9
Delay disc. indifference point, 2s delay0.00.00.0-0.0-0.10.10.0
Delay disc. indifference point, 24s delay0.30.30.60.6-0.7-0.50.4
Delay disc. indifference point, 4s delay4.24.55.22.0-2.1-2.02.3
Delay disc. indifference point, 8s delay1.01.11.51.0-0.9-0.91.2
Indifference point function ln k1.92.73.21.8-1.5-1.71.6
Indifference point function log k1.92.73.21.8-1.5-1.71.6
Patch foraging total patch changes 0 sec0.00.00.1-0.20.20.1-0.1
Patch foraging total patch changes 12 sec0.10.10.3-0.50.30.40.0
Patch foraging total patch changes 18 sec0.10.10.20.1-0.4-0.40.1
Patch foraging total patch changes 24 sec0.00.00.0-0.1-0.2-0.10.0
Patch foraging total patch changes 6 sec0.00.00.0-0.1-0.2-0.00.1
Patch foraging time to switch 0 sec0.10.10.30.1-0.00.0-0.6
Patch foraging water rate 0 sec0.10.20.60.2-0.1-0.20.8
Patch foraging water rate 12 sec0.00.00.1-0.00.30.1-0.0
Patch foraging water rate 18 sec0.10.20.4-0.20.60.3-0.4
Patch foraging water rate 24 sec0.40.50.80.9-0.4-0.70.9
Patch foraging water rate 6 sec0.00.00.10.10.1-0.20.2
Seeking ratio, delayed vs. immediate footshock3.13.54.0-1.91.72.0-2.0
Distance traveled before self-admin2.93.13.71.9-1.7-1.71.7
Distance traveled after self-admin2.02.22.71.5-1.3-1.41.6
Extensor digitorum longus weight6.224.327.55.1-5.2-5.24.0
Bone: elastic displacement0.70.80.9-0.91.00.9-0.8
Bone: elastic work0.10.10.2-0.40.40.2-0.5
Bone: endosteal estimation0.10.30.7-0.40.20.2-0.9
Bone: endosteal perimeter0.10.10.3-0.30.10.1-0.6
Epididymis fat weight0.00.10.20.4-0.2-0.10.3
Delta time in closed arm before/after self-admin2.12.13.31.4-1.8-1.60.8
Delta time in open arm before/after self-admin0.40.40.6-0.60.80.6-0.4
Diff in mean of infusions in LGA sessions0.60.61.01.0-0.7-0.90.5
Delay discount exponential model param1.51.51.7-1.21.21.2-1.3
Extinction: sum of active levers before priming0.10.10.20.3-0.3-0.20.4
Active lever presses in extinction session 60.10.10.1-0.20.10.2-0.4
Bone: final force0.30.40.70.7-0.7-0.80.2
Bone: final moment0.20.40.60.6-0.7-0.80.2
Food consumed during 24 hour testing period2.02.42.51.6-1.6-1.51.6
Glucose1.21.82.11.3-1.5-1.41.3
Heart weight0.10.20.3-0.50.30.50.0
Delay discount hyperbolic model param1.71.82.0-1.31.41.3-1.4
Intermittent access intake day 1-15 change0.50.50.6-0.80.70.8-0.7
Intermittent access intake escalation0.40.40.6-0.60.70.8-0.5
Intermittent access intake escalation 21.91.92.5-1.41.61.5-1.0
Intermitt. access day 1 inactive lever presses1.11.11.81.1-0.9-0.81.4
Intermitt. access day 15 inactive lever presses0.20.20.3-0.60.50.50.5
Intermitt. access escalation Index0.60.60.70.7-0.7-0.80.7
Intermittent access day 1 total infusions5.16.06.9-2.52.62.4-2.1
Intermittent access day 15 total infusions6.27.07.9-2.72.82.8-2.2
Intermittent access terminal intake (last 3 days)5.66.17.2-2.62.72.6-2.0
Intermittent access total infusions4.95.56.0-2.42.42.4-2.0
Intermittent access day 1 locomotion0.80.81.2-0.91.10.9-0.6
Intermittent access day 15 total locomotion0.91.01.5-1.01.20.9-0.8
Intermittent access total locomotion1.31.41.8-1.21.31.2-1.0
Intermittent access standard deviation0.50.50.6-0.70.80.8-0.5
Left kidney weight0.20.61.20.9-0.6-0.51.1
Right kidney weight0.41.21.91.1-1.0-0.81.4
Cocaine induced anxiety0.10.20.30.2-0.4-0.40.6
Post-drug Anxiety0.50.60.80.7-0.9-0.80.5
Baseline Anxiety0.20.30.6-0.30.40.5-0.8
Tail length0.61.71.91.3-1.3-1.31.4
Length with tail0.00.10.2-0.20.30.4-0.4
Length without tail2.75.96.3-2.32.42.5-2.4
Times rat made contact with spout0.50.60.60.8-0.7-0.80.7
Lifetime Intake5.36.06.8-2.62.52.6-2.1
Liver weight, left0.40.70.90.9-0.8-0.80.8
Liver weight, right0.10.20.60.2-0.2-0.10.7
Locomotor activity1.62.52.91.7-1.5-1.41.7
Locomotor testing distance0.71.11.61.1-0.9-1.01.3
Locomotor testing rearing0.10.10.50.2-0.0-0.20.7
Locomotion in novel chamber0.50.61.11.0-0.7-0.80.5
Locomotion in novel chamber post-restriction0.30.40.50.6-0.7-0.60.6
Fecal boli incidents, locomotor time 10.30.40.7-0.60.50.5-0.8
Change in fecal boli incidents, locomotor task0.10.10.1-0.20.30.3-0.1
Time >=10cm from walls, locomotor time 10.10.10.2-0.40.40.4-0.1
Bouts of movement, locomotor time 11.61.72.61.2-1.3-1.21.6
Total resting periods, locomotor time 10.30.30.50.4-0.6-0.40.7
Rest time, locomotor task time 10.30.30.50.5-0.7-0.50.5
Distance moved, locomotor task time 10.00.00.00.2-0.1-0.20.1
Vertical activity count, locomotor time 10.10.20.20.4-0.2-0.50.4
Time >=10cm from walls, locomotor time 20.00.00.1-0.20.20.2-0.2
Bouts of movement, locomotor time 23.94.24.72.1-1.9-2.02.2
Total resting periods, locomotor time 25.05.36.12.3-2.1-2.22.5
Rest time, locomotor task time 21.82.12.41.4-1.5-1.31.6
Distance moved, locomotor task time 20.00.00.1-0.10.1-0.0-0.3
Vertical activity count, locomotor time 20.20.30.50.6-0.5-0.70.1
Light reinforcement 10.30.50.60.6-0.6-0.80.7
Light reinforcement 21.21.62.41.3-1.5-1.50.5
Bone: marrow area0.10.20.6-0.30.20.2-0.8
Bone: maximum diameter1.12.02.41.4-1.5-1.51.2
Bone: maximum force0.50.91.40.9-1.0-1.20.7
Bone: maximum moment0.50.81.20.9-0.9-1.10.7
Mean time between licks in bursts1.52.12.6-1.41.41.4-1.6
Mean num. licks in bursts0.00.00.0-0.0-0.00.1-0.0
Cd content in liver2.32.52.81.7-1.5-1.61.6
Co content in liver4.14.86.52.3-1.9-2.02.6
Cu content in liver0.50.50.8-0.60.80.9-0.7
Fe content in liver1.51.72.2-1.41.11.3-1.5
K content in liver0.50.50.7-0.70.60.7-0.8
Mg content in liver1.11.11.6-0.91.01.0-1.3
Mn content in liver0.30.30.4-0.60.60.6-0.5
Na content in liver0.10.10.10.2-0.2-0.20.3
Rb content in liver0.10.10.20.2-0.2-0.20.4
Se content in liver0.00.00.00.10.1-0.0-0.1
Sr content in liver0.10.10.2-0.10.40.2-0.4
Zn content in liver0.20.30.4-0.60.60.5-0.3
Bone: minimum diameter0.10.10.5-0.00.0-0.1-0.7
Time in familiar zone, hab. session 11.31.21.71.1-1.0-1.11.3
Time in novel zone, hab. session 11.21.21.4-1.21.01.1-1.1
Total zone transitions, hab. session 10.50.61.2-0.70.70.7-1.1
Total locomotion distance, hab. session 10.91.31.8-1.11.11.1-1.3
Locomotion velocity, hab. session 10.50.71.1-0.70.80.8-1.1
Time in familiar zone, hab. session 20.10.10.1-0.2-0.00.20.4
Time in novel zone, hab. session 20.10.10.2-0.00.2-0.0-0.5
Total zone transitions, hab. session 20.00.00.1-0.1-0.3-0.2-0.3
Total locomotion distance, hab. session 20.20.20.4-0.50.20.3-0.7
Locomotion velocity, hab. session 20.20.20.5-0.50.30.3-0.7
Novel to familiar place preference ratio0.50.50.70.7-0.6-0.70.8
Novelty place preference0.60.61.00.8-0.6-0.71.0
Time in novel zone, NPP test1.21.31.81.1-1.0-1.11.3
Total zone transitions, NPP test0.00.10.2-0.10.00.1-0.5
Total locomotion distance, NPP test0.10.10.3-0.40.20.3-0.5
Locomotion velocity, NPP test0.50.70.9-0.80.70.7-1.0
Intraocular pressure1.01.42.71.0-1.6-1.20.7
Delta distance traveled before/after self-admin0.40.40.9-0.70.90.6-0.2
Delta ambulatory time before/after self-admin1.01.11.8-1.11.31.1-0.5
Parametrial fat weight0.10.10.20.1-0.4-0.20.4
Pavlov. Cond. lever latency0.10.10.2-0.2-0.10.00.5
Pavlov. Cond. magazine entry latency0.00.00.10.10.0-0.1-0.3
Pavlov. Cond. change in total contacts0.80.81.21.1-0.9-1.00.3
Pavlov. Cond. index score0.20.20.40.6-0.5-0.60.1
Pavlov. Cond. latency score0.20.20.40.7-0.4-0.60.1
Pavlov. Cond. lever contacts0.20.20.7-0.10.30.2-0.8
Pavlov. Cond. magazine entry number0.30.40.6-0.70.70.7-0.4
Pavlov. Cond. intertrial magazine entries1.92.32.8-1.51.71.7-1.2
Pavlov. Cond. lever-magazine prob. diff.0.40.50.70.8-0.7-0.80.3
Pavlov. Cond. response bias0.10.10.10.3-0.3-0.3-0.3
Pavlov. Cond. lever latency0.71.01.21.0-1.1-1.00.9
Pavlov. Cond. magazine entry latency0.00.10.2-0.0-0.1-0.1-0.5
Pavlov. Cond. change in total contacts0.81.11.8-0.91.10.9-1.3
Pavlov. Cond. index score0.50.71.1-0.70.80.7-1.1
Pavlov. Cond. latency score0.40.60.9-0.60.70.6-0.9
Pavlov. Cond. lever contacts1.01.31.5-1.11.21.1-1.2
Pavlov. Cond. magazine entry number0.10.10.2-0.0-0.1-0.00.5
Pavlov. Cond. intertrial magazine entries0.00.00.00.1-0.1-0.10.2
Pavlov. Cond. lever-magazine prob. diff.0.60.71.1-0.80.80.7-1.0
Pavlov. Cond. response bias0.91.21.8-1.01.11.0-1.3
Time in closed arm before self-admin1.82.12.7-1.61.61.5-0.9
Time in closed arm after self-admin0.70.70.80.8-0.9-0.90.7
Time in open arm before self-admin0.20.20.40.5-0.6-0.4-0.2
Time in open arm after self-admin0.10.10.20.5-0.4-0.30.1
Bone: periosteal estimation0.10.20.30.3-0.4-0.5-0.1
Bone: periosteal perimeter0.20.30.50.6-0.6-0.70.4
Bone: post-yield work0.00.10.10.1-0.2-0.20.4
Progressive ratio test 1 active lever presses0.90.91.3-1.20.91.1-0.5
Progressive ratio test 1 breakpoint1.01.01.3-1.21.01.1-0.6
Progressive ratio test 1 inactive lever presses0.10.10.2-0.40.10.4-0.1
Progressive ratio test 2 active lever presses2.42.63.0-1.71.61.7-1.4
Progressive ratio test 2 breakpoint2.42.73.1-1.71.61.8-1.5
Progressive ratio test 2 inactive lever presses0.80.91.4-1.20.91.1-0.3
Incentive Sensitization - Responses3.43.43.7-1.91.81.9-1.9
Incentive Sensitization - Breakpoint2.92.93.1-1.71.71.7-1.8
Sum of active levers in priming session hrs 5-60.80.81.1-0.70.90.9-1.0
Progressive ratio2.42.73.51.6-1.9-1.61.5
Food seeking constrained by brief footshock0.30.30.50.5-0.7-0.5-0.5
Seeking ratio, punishment vs. effort2.32.84.1-1.61.61.5-2.0
Retroperitoneal fat weight0.20.60.7-0.80.70.8-0.8
Reaction time number correct0.71.02.0-0.81.41.0-0.6
Reaction time mean minus median1.62.23.01.5-1.3-1.31.7
Reaction time mean minus median AUC1.82.42.81.7-1.4-1.41.7
Reaction time num false alarms2.23.13.9-1.81.41.7-2.0
Reaction time num false alarms AUC2.53.53.8-1.91.71.9-1.9
Reaction time trials correct on left0.71.02.0-0.81.41.0-0.6
Reaction time trials on left0.81.12.2-0.81.51.1-0.6
Reaction time mean0.50.71.00.8-1.0-0.80.5
Reaction time mean AUC0.50.71.00.9-1.0-0.90.5
Median of all reaction times0.20.20.40.5-0.6-0.5-0.1
Reaction time omissions0.10.10.20.4-0.2-0.10.5
Reaction time false alarm rate0.40.61.0-0.90.30.7-1.0
Reaction time premature initiation rate0.20.30.70.5-0.2-0.50.8
Reaction time premature initiations0.10.10.30.10.50.10.5
Std. dev. reaction times1.42.02.51.4-1.4-1.21.6
Reaction time trials completed0.81.12.2-0.81.51.1-0.6
Reaction time trials AUC0.91.42.5-0.91.61.2-0.8
Run reversals in cocaine runway, females3.73.64.22.0-2.0-2.01.4
Run reversals in cocaine runway, males1.01.01.11.1-1.0-1.10.7
Latency to leave start box in cocaine runway0.20.20.3-0.50.30.4-0.5
Latency to leave start box in cocaine runway, F1.31.41.8-1.31.31.2-0.8
Latency to leave start box in cocaine runway, M0.30.30.50.5-0.7-0.5-0.1
Std. dev. time between licks in bursts1.41.71.8-1.31.41.3-1.2
Total sessions with >9 infusions1.51.72.3-1.31.51.4-0.8
Short access day 1 total inactive lever presses0.70.71.1-1.01.00.8-0.5
Short access day 10 total inactive lever presses1.11.21.61.0-1.3-1.01.2
Short access day 1 total infusions1.01.01.3-1.11.11.1-0.7
Short access day 10 total infusions3.13.44.3-2.01.82.1-1.5
Short access total infusions4.85.46.2-2.52.32.5-2.1
Short access day 1 locomotion0.50.51.00.7-0.4-0.61.0
Short access day 10 total locomotion0.10.10.10.3-0.2-0.30.3
Short access total locomotion0.10.10.2-0.10.40.20.2
One hour access (0.3 mA shock)2.53.03.6-1.81.91.8-1.2
Compulsive drug intake2.32.43.41.8-1.6-1.60.8
One hour access (shock baseline)4.75.46.6-2.62.62.5-1.4
Social response proportion0.40.40.90.6-0.5-0.51.0
Social responses1.21.52.81.2-0.9-1.01.7
Social time0.91.21.7-1.21.31.3-0.5
Soleus weight1.34.04.91.9-2.2-2.11.8
Bone: stiffness0.40.70.70.8-0.8-0.90.9
Tibialis anterior weight3.712.814.93.8-3.8-3.92.6
Time to tail flick, vehicle, before self-admin1.21.31.4-1.21.11.1-1.1
Time to tail flick, vehicle, after self-admin2.32.53.6-1.51.41.4-1.9
Time to tail flick, test, before self-admin0.10.10.20.4-0.2-0.30.4
Time to tail flick, test, after self-admin0.50.60.9-0.71.00.9-0.1
Delta time to tail flick, vehicle, before/after SA1.81.72.3-1.31.31.2-1.5
Delta time to tail flick, test, before/after SA0.20.10.50.1-0.2-0.20.7
Tibia length0.10.30.5-0.70.50.6-0.4
Ambulatory time before self-admin1.71.72.01.4-1.3-1.31.2
Ambulatory time after self-admin0.10.10.40.3-0.2-0.30.6
Bone: tissue strength0.60.60.7-0.80.70.7-0.7
Total heroin consumption0.20.30.4-0.60.40.5-0.6
Bone: trabecular number0.40.71.1-1.10.60.6-1.0
Bone: trabecular spacing0.10.10.10.3-0.3-0.20.2
Bone: trabecular thickness1.31.52.0-1.41.11.0-1.3
Bone: trabecular tissue density0.30.40.70.5-0.7-0.50.8
Water consumed over 24 hours0.50.60.80.9-0.7-0.80.8
Number of responses in last shaping day0.70.71.50.7-0.5-0.81.2