Hub : Genes

LOC108349981

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	pVTA	gene expression	LOC108349981	0.11	0.07	9.5e-07	0.06	0.07	0.04	0.07	5.7e-06	1.8e-06	5.5e-04	2.7e-06
2	Eye	gene expression	LOC108349981	0.61	0.14	4.4e-07	0.34	0.23	0.23	0.25	3.0e-06	2.1e-04	2.2e-04	8.8e-05
3	Liver	gene expression	LOC108349981	0.36	0.14	0.0e+00	0.21	0.22	0.27	0.27	4.1e-23	3.4e-24	1.4e-29	1.0e-29
4	IC	gene expression	LOC108349981	0.12	0.08	1.2e-03	0.06	0.04	0.04	0.05	2.2e-03	5.6e-03	8.8e-03	4.9e-03
5	Liver	alternative TSS	XR_001836634.3	0.04	0.03	9.7e-04	0	0.02	0.01	0.01	1.0e-01	6.1e-03	3.7e-02	2.6e-02
6	BLA	gene expression	LOC108349981	0.1	0.08	1.3e-03	0.01	0.01	0.01	-0	1.0e-01	9.3e-02	6.9e-02	3.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.5	2.6	3.3	-1.6	-1.7	1.6	-1.8	1.7	-1.3
Area under the delay curve	1.9	2.2	2.3	1.5	1.5	-1.3	1.5	-1.5	1.5
BMI with tail	1.9	6.5	10.5	3.2	2.8	-2.3	2.9	-2.0	1.6
BMI without tail	2.9	8.9	12.9	3.6	3.2	-2.9	3.4	-2.6	1.9
Body weight	1.0	4.4	8.9	3.0	2.3	-1.4	2.4	-1.3	1.6
Weight adjusted by age	0.3	0.4	1.7	0.2	0.3	0.6	0.2	-0.2	1.3
Bone surface	1.3	2.4	3.4	-1.2	-1.6	1.8	-1.7	1.8	-1.0
Bone volume	1.9	3.4	4.1	-1.7	-1.9	1.9	-2.0	2.0	-1.4
Breakpoint value in progressive ratio session	0.1	0.1	0.5	0.3	0.0	-0.4	0.3	0.3	-0.7
Number of licking bursts	0.2	0.3	0.5	0.5	0.6	-0.7	0.6	-0.5	0.2
Context. condit. distance diff. score	0.2	0.3	0.5	0.4	0.5	-0.4	0.6	-0.7	0.4
Locomotion velocity, session 1	0.1	0.1	0.3	0.4	0.2	-0.1	0.2	-0.3	0.5
Locomotion distance, session 1	0.2	0.2	0.6	0.5	-0.2	0.8	-0.1	0.7	0.2
Locomotion velocity, session 2	0.6	0.7	2.2	1.5	0.8	-0.5	0.8	-0.2	0.6
Locomotion distance, session 2	0.6	0.9	2.4	0.3	-0.7	1.6	-0.6	1.4	-0.1
Locomotion velocity, session 3	0.0	0.1	0.1	-0.3	-0.3	-0.0	-0.2	-0.2	0.1
Locomotion distance, session 3	0.8	0.8	1.4	-0.5	-1.0	1.0	-0.9	1.2	-0.4
Stereotopy head waving bouts, day 3	0.3	0.3	0.5	-0.7	-0.7	0.5	-0.7	0.3	-0.2
Stereotopy head waving duration, day 3	0.6	0.7	1.5	0.7	0.7	-0.7	0.8	-1.2	0.9
Locomotion velocity, session 7	16.4	17.9	21.1	-3.8	-4.6	4.3	-4.6	4.6	-3.3
Locomotion distance, session 7	6.5	8.2	9.8	-2.8	-3.1	2.6	-3.1	3.0	-2.5
Stereotopy head waving bouts, day 7	0.2	0.2	0.4	0.6	0.5	-0.2	0.4	-0.2	0.4
Stereotopy head waving duration, day 7	0.9	1.1	1.5	1.2	1.2	-0.8	1.1	-1.0	1.0
Locomotion velocity, session 8	1.1	1.3	3.1	1.8	1.2	-0.8	1.1	-0.6	0.8
Locomotion distance, session 8	0.1	0.2	0.5	0.7	0.1	0.4	0.2	0.2	0.4
Degree of sensitization distance	1.1	1.1	1.5	-1.2	-1.0	0.6	-1.2	0.9	-1.2
Degree of sensitization stereotypy	2.0	2.2	3.1	1.8	1.7	-1.3	1.6	-1.2	1.2
Conditioned locomotion	0.5	0.6	0.8	-0.6	-0.9	0.6	-0.8	0.8	-0.8
Cocaine response after cond. corrected	0.4	0.5	0.7	-0.8	-0.8	0.8	-0.7	0.6	-0.4
Cocaine response after cond. not corrected	1.9	2.2	3.3	-1.8	-1.7	1.5	-1.5	1.3	-1.0
Cocaine response before conditioning	1.4	1.6	2.4	-1.5	-1.3	1.0	-1.4	1.2	-1.2
Saline control response	0.3	0.5	0.9	-0.5	-0.7	0.6	-0.7	1.0	-0.6
Bone: connectivity density	1.7	2.7	3.3	-1.5	-1.7	1.8	-1.8	1.8	-1.2
Bone: cortical apparent density	0.2	0.2	0.4	0.4	0.4	-0.2	0.5	-0.5	0.7
Bone: cortical area	1.1	1.7	2.9	1.7	1.4	-0.8	1.3	-1.0	1.3
Bone: cortical porosity	0.0	0.0	0.1	-0.2	-0.1	0.4	-0.2	-0.0	-0.0
Bone: cortical porosity	0.0	0.0	0.1	-0.3	-0.2	0.4	-0.2	-0.1	-0.0
Bone: cortical thickness	0.6	1.0	1.7	1.3	1.1	-0.5	1.0	-0.7	1.0
Bone: cortical thickness	4.4	5.2	6.2	2.5	2.5	-2.3	2.4	-2.3	1.7
Bone: cortical tissue density	0.2	0.2	0.4	0.5	0.4	-0.2	0.5	-0.5	0.7
Condit. Reinf. active minus inactive responses	0.9	1.0	2.1	-0.2	-0.8	1.2	-0.9	1.4	-0.8
Condit. Reinf. active-inactive response ratio	1.6	1.7	3.6	-0.4	-1.2	1.5	-1.2	1.9	-1.2
Condit. Reinf. active responses	0.8	1.0	2.1	-0.2	-0.9	1.4	-0.9	1.4	-0.8
Condit. Reinf. inactive responses	0.3	0.3	0.5	0.6	0.6	-0.2	0.6	-0.5	0.7
Incentive salience index mean	0.5	0.6	1.6	0.3	-0.5	1.1	-0.5	1.3	-0.5
Condit. Reinf. lever presses	0.3	0.4	1.4	1.2	0.4	0.3	0.6	0.3	0.3
Condit. Reinf. active minus inactive responses	2.6	3.4	4.7	-1.4	-1.9	2.2	-1.9	2.1	-1.4
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.5	-0.4	-1.1	1.5	-1.1	1.6	-0.8
Condit. Reinf. active responses	5.0	7.0	9.2	-2.2	-2.8	3.0	-2.8	2.9	-1.9
Condit. Reinf. inactive responses	1.3	1.7	2.1	-1.3	-1.4	1.3	-1.4	1.4	-1.0
Condit. Reinf. lever presses	1.4	2.0	4.0	-1.1	-1.4	2.0	-1.4	1.6	-0.5
Condit. Reinf. lever reinforcers received	4.5	6.3	8.9	-2.1	-2.6	3.0	-2.7	2.7	-1.6
Conditioned reinforcement - actives	1.0	1.7	3.0	-1.7	-1.4	1.3	-1.4	1.0	-0.8
Conditioned reinforcement - inactives	0.6	0.9	1.7	-0.8	-1.0	1.3	-1.0	1.1	-0.3
Conditioned locomotion	1.0	1.3	1.7	-1.2	-1.3	1.3	-1.3	0.9	-0.3
Patch foraging indifference point 0 sec	0.3	0.6	0.9	-1.0	-0.8	0.6	-0.9	0.6	-0.5
Patch foraging indifference point AUC	0.5	0.7	1.5	-0.7	-0.9	1.2	-0.9	0.8	-0.3
Delay disc. indifference point, 0s delay	0.4	0.5	0.5	0.5	0.7	-0.7	0.7	-0.7	0.7
Delay disc. indifference point, 16s delay	0.5	0.6	0.9	0.9	0.8	-0.8	0.8	-0.7	0.5
Delay disc. indifference point, 2s delay	0.5	0.6	1.8	1.0	0.4	0.5	0.4	0.0	1.3
Delay disc. indifference point, 24s delay	0.2	0.2	0.6	0.5	0.4	-0.8	0.3	-0.5	0.0
Delay disc. indifference point, 4s delay	4.2	4.4	5.1	2.1	2.2	-1.8	2.2	-2.0	2.3
Delay disc. indifference point, 8s delay	0.8	0.9	1.5	0.6	0.9	-0.8	0.9	-1.2	1.1
Indifference point function ln k	1.5	2.5	4.5	1.5	1.6	-2.1	1.6	-1.7	0.7
Indifference point function log k	1.5	2.5	4.5	1.5	1.6	-2.1	1.6	-1.7	0.7
Patch foraging total patch changes 0 sec	0.1	0.3	0.6	-0.8	-0.5	0.3	-0.7	0.3	-0.3
Patch foraging total patch changes 12 sec	0.2	0.3	0.6	-0.6	-0.4	0.7	-0.6	0.2	0.2
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.3	-0.1	0.2	-0.5	0.3	-0.2
Patch foraging total patch changes 24 sec	0.1	0.2	0.6	-0.3	-0.3	0.7	-0.4	0.3	0.3
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	-0.4	-0.1	0.2	-0.4	0.2	0.1
Patch foraging time to switch 0 sec	0.1	0.2	0.5	0.7	0.2	0.3	-0.1	0.6	-0.3
Patch foraging water rate 0 sec	0.1	0.2	0.7	-0.3	0.2	-0.4	0.3	-0.8	0.6
Patch foraging water rate 12 sec	0.0	0.1	0.1	-0.4	-0.3	0.2	-0.2	0.1	0.1
Patch foraging water rate 18 sec	0.1	0.2	0.3	-0.6	-0.5	-0.0	-0.4	0.3	-0.5
Patch foraging water rate 24 sec	0.5	0.7	1.9	0.2	0.7	-1.4	0.7	-1.0	-0.0
Patch foraging water rate 6 sec	0.1	0.1	0.4	-0.7	-0.3	-0.3	-0.1	-0.3	-0.1
Seeking ratio, delayed vs. immediate footshock	4.2	5.1	6.8	-2.6	-2.6	1.4	-2.5	1.8	-2.5
Distance traveled before self-admin	3.3	4.3	6.6	2.6	2.4	-1.9	2.1	-1.7	1.5
Distance traveled after self-admin	1.4	1.7	2.6	1.6	1.6	-1.0	1.4	-1.1	0.9
Extensor digitorum longus weight	6.0	23.8	42.6	6.5	5.3	-4.0	5.2	-3.7	3.9
Bone: elastic displacement	0.5	0.6	0.7	-0.8	-0.8	0.6	-0.8	0.7	-0.9
Bone: elastic work	0.1	0.1	0.3	-0.1	-0.3	0.5	-0.4	0.5	-0.1
Bone: endosteal estimation	0.1	0.2	0.4	0.5	-0.2	0.6	-0.2	0.6	-0.1
Bone: endosteal perimeter	0.0	0.1	0.3	0.3	-0.1	0.5	-0.3	0.4	0.1
Epididymis fat weight	0.1	0.2	0.4	0.6	0.4	-0.6	0.4	-0.3	-0.1
Delta time in closed arm before/after self-admin	1.0	0.9	1.4	1.2	0.9	-1.2	0.9	-0.9	0.4
Delta time in open arm before/after self-admin	0.4	0.4	0.9	-0.6	-0.5	0.3	-0.6	0.7	-1.0
Diff in mean of infusions in LGA sessions	0.4	0.5	1.0	1.0	0.9	-0.5	1.0	-0.2	0.1
Delay discount exponential model param	1.6	1.8	2.2	-1.3	-1.4	1.2	-1.3	1.4	-1.5
Extinction: sum of active levers before priming	0.6	0.7	1.0	-1.0	-0.9	0.7	-0.9	0.8	-0.7
Active lever presses in extinction session 6	0.0	0.0	0.1	0.2	0.0	-0.3	0.1	-0.2	-0.2
Bone: final force	0.4	0.7	2.1	1.5	0.9	-0.3	0.7	-0.2	0.8
Bone: final moment	0.4	0.6	1.9	1.4	0.9	-0.3	0.7	-0.2	0.8
Food consumed during 24 hour testing period	1.4	2.0	2.3	1.4	1.5	-1.5	1.5	-1.5	1.1
Glucose	1.0	1.6	2.2	1.3	1.3	-1.5	1.2	-1.3	0.9
Heart weight	0.1	0.2	0.3	0.2	0.4	-0.4	0.4	-0.6	0.5
Delay discount hyperbolic model param	1.8	2.0	2.7	-1.5	-1.4	1.0	-1.4	1.4	-1.7
Intermittent access intake day 1-15 change	0.7	1.5	2.4	-1.0	-1.4	1.6	-1.3	1.2	-0.4
Intermittent access intake escalation	1.1	2.2	3.5	-1.2	-1.7	1.9	-1.7	1.5	-0.6
Intermittent access intake escalation 2	3.3	3.7	5.8	-1.8	-2.3	2.4	-2.2	1.7	-0.7
Intermitt. access day 1 inactive lever presses	0.5	1.8	2.3	1.3	1.5	-1.4	1.5	-1.4	1.0
Intermitt. access day 15 inactive lever presses	0.1	0.2	0.8	-0.9	-0.2	0.4	-0.2	-0.4	0.4
Intermitt. access escalation Index	0.0	0.0	0.1	-0.1	0.1	-0.1	0.1	-0.3	0.1
Intermittent access day 1 total infusions	3.2	5.1	6.2	-1.9	-2.4	2.5	-2.4	2.5	-1.8
Intermittent access day 15 total infusions	4.8	7.2	10.4	-2.2	-2.9	3.2	-2.9	2.8	-1.7
Intermittent access terminal intake (last 3 days)	5.0	6.6	8.9	-2.4	-2.8	3.0	-2.8	2.6	-1.7
Intermittent access total infusions	3.4	4.0	5.2	-1.7	-2.2	2.3	-2.1	2.1	-1.4
Intermittent access day 1 locomotion	0.9	1.1	1.9	-0.6	-1.1	1.4	-1.1	1.2	-0.6
Intermittent access day 15 total locomotion	0.4	0.8	2.0	-0.3	-1.0	1.4	-0.8	1.0	0.2
Intermittent access total locomotion	2.0	2.4	4.8	-1.2	-1.7	2.2	-1.6	1.6	-0.4
Intermittent access standard deviation	0.3	0.6	1.1	-0.6	-0.9	1.0	-1.0	0.8	-0.3
Left kidney weight	0.4	1.7	2.6	0.7	1.4	-1.4	1.3	-1.6	1.2
Right kidney weight	0.3	1.4	1.6	1.1	1.1	-1.2	1.2	-1.2	1.1
Cocaine induced anxiety	0.2	0.2	0.9	0.4	0.2	0.5	0.2	-0.3	0.9
Post-drug Anxiety	0.2	0.2	0.3	0.6	0.4	0.1	0.4	-0.2	0.6
Baseline Anxiety	0.2	0.2	0.4	0.3	0.4	-0.6	0.4	-0.0	-0.5
Tail length	0.2	0.8	1.2	1.1	1.0	-0.7	1.0	-0.6	0.8
Length with tail	0.0	0.1	0.2	0.5	0.1	0.4	0.1	0.5	0.4
Length without tail	0.2	0.8	1.4	-0.6	-0.9	1.1	-0.9	1.2	-0.4
Times rat made contact with spout	0.5	0.6	1.3	0.7	0.7	-1.1	0.8	-0.7	0.2
Lifetime Intake	3.0	3.7	4.5	-1.7	-2.1	2.1	-2.1	1.9	-1.4
Liver weight, left	0.1	0.2	0.5	0.7	0.4	-0.2	0.6	-0.0	0.4
Liver weight, right	0.8	1.5	2.4	0.7	1.2	-0.8	1.3	-1.5	1.5
Locomotor activity	1.9	2.9	4.4	2.1	1.9	-1.1	1.9	-1.4	1.7
Locomotor testing distance	0.8	1.5	2.3	1.5	1.3	-0.5	1.3	-0.8	1.5
Locomotor testing rearing	0.1	0.2	0.5	-0.0	0.4	-0.3	0.4	-0.6	0.7
Locomotion in novel chamber	0.5	0.7	2.2	1.5	0.8	-0.4	0.8	-0.1	0.5
Locomotion in novel chamber post-restriction	0.4	0.6	1.4	0.6	0.7	-1.2	0.7	-0.9	0.3
Fecal boli incidents, locomotor time 1	0.3	0.5	0.9	-0.5	-0.7	0.9	-0.8	0.7	-0.4
Change in fecal boli incidents, locomotor task	0.2	0.2	0.3	-0.6	-0.6	-0.3	-0.2	0.1	-0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.2	0.1	0.3
Bouts of movement, locomotor time 1	1.1	1.3	2.9	0.0	1.1	-1.7	0.9	-1.7	0.5
Total resting periods, locomotor time 1	0.2	0.3	0.7	-0.5	0.3	-0.7	0.1	-0.8	-0.0
Rest time, locomotor task time 1	0.1	0.1	0.2	-0.2	0.0	-0.4	-0.0	-0.2	-0.5
Distance moved, locomotor task time 1	0.2	0.3	0.7	0.8	0.5	-0.0	0.5	-0.1	0.7
Vertical activity count, locomotor time 1	0.4	0.9	2.0	1.3	0.8	-0.0	1.0	-0.3	1.4
Time >=10cm from walls, locomotor time 2	0.0	0.0	0.1	-0.2	-0.2	0.1	-0.2	0.3	-0.3
Bouts of movement, locomotor time 2	1.9	3.0	5.5	0.9	1.8	-2.3	1.6	-2.2	1.0
Total resting periods, locomotor time 2	2.2	3.8	6.9	0.9	2.1	-2.6	1.8	-2.6	1.1
Rest time, locomotor task time 2	1.2	1.5	3.1	0.6	1.3	-1.8	1.1	-1.6	0.5
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.6	0.2	0.2	0.2	0.3	0.1
Vertical activity count, locomotor time 2	0.7	1.0	3.5	1.9	1.0	-0.1	1.1	0.1	0.7
Light reinforcement 1	0.2	0.5	0.7	0.7	0.8	-0.4	0.7	-0.8	0.9
Light reinforcement 2	0.7	1.1	2.2	1.5	1.1	-1.5	1.0	-0.5	0.0
Bone: marrow area	0.1	0.2	0.3	0.6	-0.1	0.5	-0.1	0.6	0.0
Bone: maximum diameter	1.4	2.6	4.3	2.1	1.8	-1.1	1.7	-1.4	1.5
Bone: maximum force	0.6	1.1	2.1	1.4	1.2	-0.7	1.0	-0.8	1.1
Bone: maximum moment	0.6	1.0	1.8	1.3	1.1	-0.7	1.0	-0.8	1.0
Mean time between licks in bursts	0.8	1.9	4.3	-0.9	-1.4	2.1	-1.3	1.6	-0.4
Mean num. licks in bursts	0.0	0.0	0.0	-0.1	-0.2	-0.0	-0.1	0.1	-0.1
Cd content in liver	1.4	1.6	2.8	0.9	1.2	-1.7	1.3	-1.5	0.6
Co content in liver	2.4	2.8	4.7	1.0	1.8	-2.0	1.7	-2.2	1.2
Cu content in liver	0.2	0.2	0.5	-0.7	-0.5	0.4	-0.4	0.4	-0.3
Fe content in liver	0.3	0.4	0.7	-0.5	-0.6	0.9	-0.6	0.7	-0.2
K content in liver	0.4	0.4	1.2	-0.4	-0.3	1.1	-0.6	0.8	-0.1
Mg content in liver	0.7	0.7	1.2	-0.6	-0.5	1.1	-0.8	1.0	-0.6
Mn content in liver	0.3	0.3	0.6	-0.8	-0.4	0.5	-0.7	0.4	-0.6
Na content in liver	0.2	0.2	0.3	0.5	0.5	-0.5	0.4	-0.2	0.2
Rb content in liver	0.1	0.1	0.2	-0.5	-0.1	0.2	-0.1	-0.3	-0.1
Se content in liver	0.0	0.0	0.1	-0.1	0.1	-0.3	0.1	-0.1	-0.1
Sr content in liver	0.4	0.3	0.9	-0.3	-0.5	0.5	-0.5	1.0	-0.5
Zn content in liver	0.8	0.9	2.3	-1.5	-0.8	0.3	-1.0	0.6	-1.0
Bone: minimum diameter	0.2	0.4	1.0	1.0	0.0	0.9	-0.0	0.7	0.2
Time in familiar zone, hab. session 1	1.2	1.1	1.9	0.6	1.1	-1.4	1.0	-1.2	0.7
Time in novel zone, hab. session 1	1.2	1.2	1.6	-1.1	-1.2	1.3	-1.2	1.0	-0.6
Total zone transitions, hab. session 1	0.3	0.5	1.1	-0.1	-0.6	0.8	-0.7	1.1	-0.4
Total locomotion distance, hab. session 1	0.8	1.2	2.1	-0.6	-1.1	1.5	-1.1	1.4	-0.5
Locomotion velocity, hab. session 1	0.4	0.6	1.3	-0.1	-0.7	1.1	-0.7	1.1	-0.4
Time in familiar zone, hab. session 2	0.2	0.2	0.6	-0.8	-0.1	-0.2	-0.1	-0.6	-0.0
Time in novel zone, hab. session 2	0.1	0.1	0.4	0.3	-0.1	0.1	-0.1	0.6	-0.3
Total zone transitions, hab. session 2	0.1	0.1	0.3	0.2	-0.2	0.6	-0.1	0.2	0.4
Total locomotion distance, hab. session 2	0.4	0.6	2.1	-0.2	-0.7	1.5	-0.5	0.7	0.4
Locomotion velocity, hab. session 2	0.5	0.6	2.4	-0.1	-0.7	1.6	-0.5	0.7	0.4
Novel to familiar place preference ratio	0.5	0.5	0.9	0.6	0.8	-0.9	0.7	-0.8	0.5
Novelty place preference	0.7	0.7	1.2	0.6	0.9	-1.1	0.8	-1.0	0.6
Time in novel zone, NPP test	1.2	1.3	2.1	0.8	1.2	-1.5	1.1	-1.3	0.8
Total zone transitions, NPP test	0.1	0.1	0.4	0.2	-0.2	0.7	-0.1	0.4	0.3
Total locomotion distance, NPP test	0.2	0.3	0.9	-0.1	-0.5	1.0	-0.4	0.6	0.3
Locomotion velocity, NPP test	0.6	0.8	2.1	-0.5	-0.9	1.4	-0.7	1.0	-0.0
Intraocular pressure	0.6	0.9	1.9	1.4	0.9	-1.0	1.0	-0.5	0.5
Delta distance traveled before/after self-admin	1.1	1.2	2.3	-1.3	-1.1	1.5	-1.0	0.9	-0.5
Delta ambulatory time before/after self-admin	1.6	2.0	3.6	-1.7	-1.4	1.9	-1.3	1.1	-0.5
Parametrial fat weight	0.1	0.3	0.6	-0.4	-0.5	0.8	-0.6	0.6	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.9	-0.9	-0.2	-0.8	-0.1	-0.7	-0.1
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	0.3	0.1	-0.1	-0.0	0.3	-0.5
Pavlov. Cond. change in total contacts	0.9	0.9	2.9	1.7	1.0	-0.7	1.0	-0.2	0.2
Pavlov. Cond. index score	0.2	0.3	1.1	1.1	0.6	-0.0	0.5	0.1	0.2
Pavlov. Cond. latency score	0.2	0.3	1.2	1.1	0.6	0.1	0.5	0.1	0.2
Pavlov. Cond. lever contacts	0.4	0.5	1.2	0.8	-0.1	1.1	-0.1	1.0	-0.0
Pavlov. Cond. magazine entry number	0.3	0.3	0.6	-0.8	-0.6	0.8	-0.6	0.3	0.1
Pavlov. Cond. intertrial magazine entries	1.8	2.1	4.2	-2.0	-1.6	1.3	-1.5	1.1	-1.0
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.3	1.1	0.7	-0.2	0.7	-0.1	0.3
Pavlov. Cond. response bias	0.2	0.2	0.9	0.9	0.4	-0.0	0.3	0.3	-0.2
Pavlov. Cond. lever latency	0.9	1.2	1.4	1.1	1.2	-1.2	1.2	-1.1	0.7
Pavlov. Cond. magazine entry latency	0.1	0.1	0.4	0.2	-0.1	0.2	-0.1	0.6	-0.4
Pavlov. Cond. change in total contacts	0.6	0.9	2.0	-0.2	-0.9	1.4	-0.8	1.4	-0.4
Pavlov. Cond. index score	0.5	0.7	1.4	-0.4	-0.8	1.0	-0.8	1.2	-0.5
Pavlov. Cond. latency score	0.5	0.7	1.3	-0.5	-0.8	1.0	-0.8	1.1	-0.6
Pavlov. Cond. lever contacts	1.0	1.4	1.7	-1.1	-1.3	1.3	-1.3	1.3	-0.8
Pavlov. Cond. magazine entry number	0.1	0.1	0.4	-0.4	0.1	-0.3	0.1	-0.6	0.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.2	-0.0	0.3	0.0	-0.0	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.6	0.8	1.4	-0.5	-0.8	1.1	-0.8	1.2	-0.6
Pavlov. Cond. response bias	0.8	1.0	1.8	-0.5	-1.0	1.2	-1.0	1.3	-0.7
Time in closed arm before self-admin	0.5	0.6	1.9	-1.4	-0.8	0.6	-0.6	0.3	-0.7
Time in closed arm after self-admin	1.6	1.7	3.0	0.9	1.3	-1.7	1.5	-1.5	0.3
Time in open arm before self-admin	0.2	0.3	0.9	1.0	0.4	-0.3	0.4	-0.1	0.5
Time in open arm after self-admin	0.3	0.3	1.1	1.1	0.6	-0.5	0.4	-0.0	0.2
Bone: periosteal estimation	0.2	0.5	1.9	1.4	0.6	0.1	0.5	0.0	0.7
Bone: periosteal perimeter	0.3	0.6	1.2	1.1	0.9	-0.2	0.7	-0.7	0.9
Bone: post-yield work	0.1	0.1	0.4	-0.6	-0.1	-0.2	-0.1	-0.5	0.3
Progressive ratio test 1 active lever presses	1.2	1.5	2.0	-1.2	-1.4	1.2	-1.3	1.1	-1.2
Progressive ratio test 1 breakpoint	1.4	1.7	2.2	-1.3	-1.5	1.3	-1.3	1.2	-1.2
Progressive ratio test 1 inactive lever presses	0.6	0.8	1.3	-0.7	-0.9	0.8	-0.8	1.0	-1.1
Progressive ratio test 2 active lever presses	2.1	2.5	3.2	-1.2	-1.8	1.8	-1.6	1.8	-1.1
Progressive ratio test 2 breakpoint	2.3	2.7	3.4	-1.3	-1.8	1.8	-1.7	1.8	-1.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	-0.1	-0.0	0.2	0.0	-0.0	0.2
Incentive Sensitization - Responses	1.8	2.5	3.7	-1.2	-1.8	1.7	-1.7	1.9	-1.1
Incentive Sensitization - Breakpoint	1.8	2.3	3.3	-1.2	-1.7	1.6	-1.6	1.8	-1.0
Sum of active levers in priming session hrs 5-6	1.6	1.5	1.6	-1.3	-1.3	1.3	-1.3	1.3	-1.0
Progressive ratio	2.3	3.6	5.6	1.8	1.8	-2.4	2.1	-2.0	1.0
Food seeking constrained by brief footshock	0.5	0.6	2.8	1.7	0.5	0.0	0.5	0.5	0.0
Seeking ratio, punishment vs. effort	1.8	2.7	4.5	-0.9	-1.5	2.1	-1.7	2.1	-1.2
Retroperitoneal fat weight	0.0	0.1	0.3	0.2	-0.2	0.5	-0.2	0.6	-0.3
Reaction time number correct	0.3	0.6	1.0	-0.9	-0.8	1.0	-0.7	0.8	0.0
Reaction time mean minus median	0.8	2.1	2.7	1.3	1.5	-1.3	1.5	-1.6	1.4
Reaction time mean minus median AUC	0.9	2.2	2.5	1.5	1.6	-1.2	1.6	-1.5	1.6
Reaction time num false alarms	2.1	3.0	3.9	-1.2	-1.8	1.8	-1.9	2.0	-1.5
Reaction time num false alarms AUC	2.1	3.3	4.3	-1.5	-2.0	1.8	-2.1	2.0	-1.6
Reaction time trials correct on left	0.3	0.6	1.0	-0.9	-0.8	1.0	-0.7	0.8	0.0
Reaction time trials on left	0.3	0.6	1.2	-0.9	-0.8	1.1	-0.7	0.8	0.0
Reaction time mean	0.2	0.4	1.1	1.0	0.6	-0.7	0.4	-0.4	-0.0
Reaction time mean AUC	0.2	0.4	1.0	1.0	0.6	-0.7	0.5	-0.4	0.1
Median of all reaction times	0.1	0.2	0.5	0.7	0.1	-0.3	-0.1	0.3	-0.6
Reaction time omissions	0.1	0.1	0.4	0.2	0.1	0.6	-0.1	-0.0	0.5
Reaction time false alarm rate	0.6	0.8	1.3	-0.6	-0.9	0.6	-1.1	0.9	-1.1
Reaction time premature initiation rate	0.3	0.4	1.1	0.1	0.6	-0.5	0.5	-1.1	0.7
Reaction time premature initiations	0.1	0.2	0.7	-0.4	0.2	0.0	0.2	-0.6	0.8
Std. dev. reaction times	1.0	1.8	2.3	1.4	1.4	-1.4	1.4	-1.5	1.0
Reaction time trials completed	0.3	0.6	1.2	-0.9	-0.8	1.1	-0.7	0.8	0.0
Reaction time trials AUC	0.4	0.8	1.6	-1.0	-0.9	1.2	-0.8	1.0	-0.0
Run reversals in cocaine runway, females	2.1	2.1	5.2	2.3	1.6	-1.0	1.3	-1.0	1.2
Run reversals in cocaine runway, males	1.0	1.0	2.0	1.4	1.0	-0.1	1.0	-0.4	1.4
Latency to leave start box in cocaine runway	0.1	0.1	0.4	-0.6	-0.5	0.1	-0.4	0.2	-0.2
Latency to leave start box in cocaine runway, F	0.8	0.9	2.5	-1.6	-1.0	0.9	-0.9	0.4	-0.2
Latency to leave start box in cocaine runway, M	0.5	0.5	1.3	1.1	0.6	-0.9	0.6	-0.2	-0.1
Std. dev. time between licks in bursts	1.0	1.4	1.7	-1.2	-1.3	1.3	-1.2	1.1	-0.9
Total sessions with >9 infusions	1.4	1.8	2.2	-1.4	-1.5	1.0	-1.4	1.2	-1.5
Short access day 1 total inactive lever presses	0.1	0.2	0.6	-0.8	-0.4	-0.0	-0.4	-0.1	-0.4
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.3	0.4	-0.2	0.2	-0.4	0.4
Short access day 1 total infusions	0.9	1.2	1.5	-1.2	-1.2	0.7	-1.2	0.9	-1.2
Short access day 10 total infusions	2.7	3.5	4.1	-1.9	-2.0	1.8	-2.0	1.7	-1.7
Short access total infusions	3.2	4.1	4.8	-1.9	-2.2	1.8	-2.2	2.0	-2.1
Short access day 1 locomotion	0.3	0.3	0.5	0.7	0.6	-0.5	0.6	-0.5	0.5
Short access day 10 total locomotion	0.0	0.0	0.1	0.2	-0.1	0.2	-0.0	0.2	0.0
Short access total locomotion	0.0	0.0	0.0	0.2	0.1	-0.0	0.1	-0.0	-0.1
One hour access (0.3 mA shock)	1.5	1.8	3.1	-1.1	-1.4	1.8	-1.4	1.4	-0.6
Compulsive drug intake	2.0	2.4	3.7	1.9	1.8	-1.8	1.7	-1.0	0.3
One hour access (shock baseline)	2.6	4.0	6.9	-2.0	-2.3	2.6	-2.1	1.8	-0.6
Social response proportion	0.5	0.5	1.1	0.2	0.7	-1.0	0.7	-1.1	0.1
Social responses	1.2	1.5	3.0	0.3	1.2	-1.6	1.2	-1.7	0.9
Social time	0.9	1.3	2.8	-1.7	-1.1	1.5	-0.9	0.5	0.3
Soleus weight	1.1	3.3	4.7	2.2	1.9	-1.8	1.9	-1.6	1.4
Bone: stiffness	0.5	0.7	1.0	0.9	0.9	-1.0	0.8	-0.8	0.6
Tibialis anterior weight	4.3	14.4	32.9	5.7	4.1	-2.6	4.0	-2.2	3.0
Time to tail flick, vehicle, before self-admin	0.7	0.8	1.1	-0.9	-1.0	0.9	-0.7	1.0	-0.7
Time to tail flick, vehicle, after self-admin	1.6	2.1	3.5	-1.3	-1.4	1.0	-1.6	1.5	-1.9
Time to tail flick, test, before self-admin	0.2	0.2	0.2	0.5	0.5	-0.4	0.5	-0.5	0.1
Time to tail flick, test, after self-admin	0.6	0.6	1.2	-1.0	-0.7	1.1	-0.8	0.2	0.4
Delta time to tail flick, vehicle, before/after SA	1.7	1.6	2.5	-1.3	-1.2	1.2	-1.6	1.1	-1.1
Delta time to tail flick, test, before/after SA	0.1	0.1	0.6	-0.1	0.1	0.1	-0.0	-0.3	0.8
Tibia length	0.1	0.2	0.5	-0.7	-0.5	0.4	-0.4	0.3	-0.1
Ambulatory time before self-admin	2.0	3.0	5.2	2.3	1.9	-1.6	1.8	-1.3	1.1
Ambulatory time after self-admin	0.1	0.1	0.3	0.5	0.4	0.2	0.4	-0.0	0.3
Bone: tissue strength	1.3	1.3	2.1	-1.4	-1.2	1.1	-1.3	0.9	-0.8
Total heroin consumption	0.6	0.7	0.9	-0.8	-1.0	0.7	-0.7	0.9	-0.9
Bone: trabecular number	0.3	0.5	0.7	-0.6	-0.7	0.8	-0.9	0.7	-0.4
Bone: trabecular spacing	0.1	0.1	0.2	0.3	0.2	-0.5	0.4	-0.2	-0.0
Bone: trabecular thickness	1.1	1.4	1.7	-1.3	-1.3	1.0	-1.3	1.2	-1.0
Bone: trabecular tissue density	0.2	0.4	1.0	-0.0	0.4	-1.0	0.4	-0.9	0.3
Water consumed over 24 hours	0.4	0.6	1.1	0.7	0.8	-1.0	0.8	-0.7	0.4
Number of responses in last shaping day	0.0	0.0	0.1	-0.0	-0.1	0.3	-0.1	0.1	0.2