LOC108349559

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	XR_005493975.2	0.07	0.07	2.2e-05	0.03	0.03	0.04	0.03	2.2e-04	1.9e-04	2.1e-05	6.7e-04
2	Adipose	alternative polyA	XR_005493969.2	0.07	0.06	2.2e-06	0.04	0.04	0.04	0.04	2.6e-05	6.3e-05	2.1e-05	6.3e-05
3	PL	gene expression	LOC108349559	0.05	0.03	1.0e-06	0.07	0.05	0.06	0.06	6.0e-08	3.4e-06	1.9e-07	3.3e-07
4	Adipose	gene expression	LOC108349559	0.12	0.09	1.0e-11	0.08	0.08	0.07	0.08	6.0e-09	5.5e-09	4.6e-08	8.8e-09
5	PL	alternative polyA	XR_005493969.2	0.05	0.03	1.9e-06	0.06	0.06	0.06	0.06	1.0e-06	8.4e-07	9.8e-07	7.8e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.6	1.0	2.0	0.1	-0.5	1.4	0.9	-1.4
Area under the delay curve	0.8	0.9	1.9	1.4	-1.3	0.8	0.7	-0.2
BMI with tail	0.0	0.1	0.2	-0.2	0.3	-0.4	-0.4	0.4
BMI without tail	0.4	1.1	1.8	1.3	-1.4	0.8	0.9	-0.7
Body weight	2.5	11.1	16.1	2.0	-2.6	3.9	3.7	-4.0
Weight adjusted by age	0.3	0.4	1.0	-1.0	0.9	0.5	0.2	-0.5
Bone surface	1.6	2.9	3.6	1.5	-1.6	1.9	1.8	-1.7
Bone volume	1.5	2.8	3.9	1.1	-1.4	2.0	1.8	-1.9
Breakpoint value in progressive ratio session	1.8	2.1	4.1	2.0	-2.0	0.7	1.2	-0.8
Number of licking bursts	2.1	3.5	4.9	-1.2	1.7	-2.1	-1.9	2.2
Context. condit. distance diff. score	0.0	0.0	0.1	0.4	-0.2	-0.2	0.1	-0.1
Locomotion velocity, session 1	0.5	0.5	0.8	-0.9	0.8	-0.6	-0.8	0.3
Locomotion distance, session 1	0.7	0.9	1.2	1.1	-1.0	0.7	0.9	-0.9
Locomotion velocity, session 2	0.6	0.7	1.4	0.2	0.1	-1.2	-0.8	1.2
Locomotion distance, session 2	0.8	1.1	2.1	-0.1	0.6	-1.5	-1.2	1.3
Locomotion velocity, session 3	0.2	0.2	0.4	-0.2	0.4	-0.7	-0.4	0.5
Locomotion distance, session 3	3.9	4.2	7.4	2.7	-2.5	1.3	2.1	-1.2
Stereotopy head waving bouts, day 3	0.9	1.1	2.2	-1.5	1.2	-0.6	-1.1	0.5
Stereotopy head waving duration, day 3	1.9	2.2	3.8	-1.9	1.7	-0.9	-1.6	0.9
Locomotion velocity, session 7	0.6	0.6	1.0	1.0	-0.9	0.5	0.8	-0.6
Locomotion distance, session 7	0.3	0.3	0.5	0.6	-0.6	0.3	0.6	-0.7
Stereotopy head waving bouts, day 7	1.3	1.5	2.9	-0.6	1.0	-1.2	-1.3	1.7
Stereotopy head waving duration, day 7	2.0	2.4	3.1	-1.3	1.5	-1.5	-1.7	1.8
Locomotion velocity, session 8	2.7	3.3	5.2	-1.0	1.4	-2.3	-2.0	2.1
Locomotion distance, session 8	0.4	0.6	1.4	0.4	0.1	-1.2	-0.6	1.0
Degree of sensitization distance	0.7	0.7	1.6	-1.3	1.1	-0.5	-0.7	0.2
Degree of sensitization stereotypy	0.9	1.0	2.7	-0.1	0.6	-1.0	-1.0	1.6
Conditioned locomotion	0.4	0.4	0.9	-0.0	0.2	-0.7	-0.8	0.9
Cocaine response after cond. corrected	0.3	0.4	1.0	-1.0	0.7	-0.4	-0.4	-0.1
Cocaine response after cond. not corrected	0.2	0.3	0.9	-0.9	0.6	-0.3	-0.3	-0.2
Cocaine response before conditioning	1.3	1.6	1.9	1.3	-1.3	1.3	1.4	-0.9
Saline control response	0.1	0.2	0.3	-0.4	0.3	-0.5	-0.4	0.3
Bone: connectivity density	0.3	0.4	0.6	0.6	-0.6	0.8	0.6	-0.5
Bone: cortical apparent density	1.3	1.8	2.2	-1.3	1.4	-1.5	-1.4	1.0
Bone: cortical area	1.3	2.0	2.9	0.9	-1.3	1.5	1.6	-1.7
Bone: cortical porosity	1.0	1.0	3.7	0.5	0.1	-0.8	-0.8	1.9
Bone: cortical porosity	1.3	1.4	4.8	0.4	0.3	-1.1	-1.0	2.2
Bone: cortical thickness	0.5	0.8	1.6	0.4	-0.7	0.9	0.9	-1.3
Bone: cortical thickness	0.7	0.8	1.1	-1.0	1.0	-0.8	-0.9	0.5
Bone: cortical tissue density	1.5	2.0	2.5	-1.3	1.5	-1.6	-1.5	1.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.3	0.4	-0.4	-0.5	0.4
Condit. Reinf. active-inactive response ratio	0.4	0.4	1.0	-1.0	0.8	-0.2	-0.7	0.2
Condit. Reinf. active responses	1.5	1.9	2.7	-0.9	1.1	-1.6	-1.6	1.5
Condit. Reinf. inactive responses	1.6	1.9	3.4	-0.2	0.7	-1.9	-1.4	1.8
Incentive salience index mean	0.1	0.1	0.2	0.0	0.1	-0.5	-0.5	0.5
Condit. Reinf. lever presses	0.2	0.2	0.6	0.8	-0.6	-0.3	-0.0	0.4
Condit. Reinf. active minus inactive responses	1.3	1.7	2.9	1.6	-1.7	0.9	1.2	-0.8
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	-0.2	0.2	-0.5	-0.3	0.2
Condit. Reinf. active responses	3.7	5.1	7.2	2.6	-2.7	2.0	2.3	-1.6
Condit. Reinf. inactive responses	4.9	6.4	9.7	3.1	-3.0	2.2	2.5	-1.4
Condit. Reinf. lever presses	7.3	10.0	11.7	3.1	-3.4	3.2	3.3	-2.8
Condit. Reinf. lever reinforcers received	4.2	5.9	8.2	2.9	-2.9	2.1	2.4	-1.6
Conditioned reinforcement - actives	0.4	0.7	1.1	-0.5	0.7	-1.0	-0.9	1.0
Conditioned reinforcement - inactives	0.8	1.2	3.3	1.8	-1.4	0.2	0.5	0.6
Conditioned locomotion	1.8	2.3	3.5	-0.8	1.1	-1.8	-1.7	1.9
Patch foraging indifference point 0 sec	0.1	0.2	0.5	0.7	-0.6	0.0	0.4	0.1
Patch foraging indifference point AUC	0.6	0.9	1.0	-0.9	1.0	-0.8	-1.0	0.9
Delay disc. indifference point, 0s delay	0.8	0.9	2.1	1.5	-1.3	0.3	0.6	-0.5
Delay disc. indifference point, 16s delay	1.7	1.9	4.1	2.0	-1.9	0.9	0.9	-0.1
Delay disc. indifference point, 2s delay	1.2	1.3	1.8	1.4	-1.3	1.1	1.1	-0.9
Delay disc. indifference point, 24s delay	1.9	2.1	2.8	1.6	-1.7	1.3	1.5	-1.1
Delay disc. indifference point, 4s delay	0.3	0.4	0.8	0.9	-0.6	0.1	0.0	0.7
Delay disc. indifference point, 8s delay	0.2	0.3	0.5	0.6	-0.6	0.7	0.4	-0.2
Indifference point function ln k	0.3	0.6	1.0	0.9	-1.0	0.4	0.7	-0.7
Indifference point function log k	0.3	0.6	1.0	0.9	-1.0	0.4	0.7	-0.7
Patch foraging total patch changes 0 sec	0.2	0.3	0.8	0.9	-0.8	0.1	0.5	0.0
Patch foraging total patch changes 12 sec	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.1	0.5
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.0	0.3	-0.2	-0.2	0.6
Patch foraging total patch changes 24 sec	0.4	0.7	1.0	0.8	-0.7	1.0	1.0	-0.7
Patch foraging total patch changes 6 sec	0.0	0.0	0.1	-0.1	0.1	-0.3	0.0	0.3
Patch foraging time to switch 0 sec	0.4	0.8	1.1	-0.6	0.6	-1.0	-1.0	1.0
Patch foraging water rate 0 sec	0.4	0.8	1.0	-0.7	1.0	-0.9	-0.9	1.0
Patch foraging water rate 12 sec	0.4	0.9	1.9	0.9	-0.6	1.4	1.1	-0.5
Patch foraging water rate 18 sec	0.1	0.1	0.3	-0.2	0.4	0.1	-0.3	0.5
Patch foraging water rate 24 sec	0.3	0.4	1.5	1.2	-0.7	0.2	0.3	0.4
Patch foraging water rate 6 sec	1.0	1.5	2.0	1.4	-1.1	1.4	1.4	-0.7
Seeking ratio, delayed vs. immediate footshock	1.8	2.2	3.5	1.9	-1.7	1.3	1.5	-0.9
Distance traveled before self-admin	0.9	1.2	3.2	1.8	-1.6	0.0	0.4	0.1
Distance traveled after self-admin	2.5	3.1	3.7	1.8	-1.9	1.9	1.7	-1.3
Extensor digitorum longus weight	0.6	2.5	6.6	-2.6	2.0	-0.5	-1.1	-0.6
Bone: elastic displacement	0.0	0.0	0.0	-0.2	0.1	0.2	-0.0	-0.0
Bone: elastic work	1.7	2.3	3.3	1.2	-1.4	1.8	1.5	-1.6
Bone: endosteal estimation	1.4	3.1	3.7	1.6	-1.8	1.9	1.9	-1.6
Bone: endosteal perimeter	1.3	2.9	3.9	1.9	-2.0	1.5	1.8	-1.2
Epididymis fat weight	0.1	0.3	0.5	-0.6	0.5	0.5	0.0	-0.7
Delta time in closed arm before/after self-admin	1.0	0.9	1.8	0.2	-0.5	1.3	1.0	-1.3
Delta time in open arm before/after self-admin	0.9	0.9	1.2	-0.9	1.0	-1.1	-0.7	0.9
Diff in mean of infusions in LGA sessions	0.5	0.6	1.2	0.5	-0.3	-1.1	-0.7	0.9
Delay discount exponential model param	0.8	0.9	1.6	-1.3	1.2	-0.9	-0.8	0.2
Extinction: sum of active levers before priming	3.1	3.5	6.2	1.0	-1.6	2.0	1.9	-2.5
Active lever presses in extinction session 6	1.0	1.0	1.8	0.5	-1.0	1.0	1.0	-1.3
Bone: final force	1.6	2.6	3.5	1.1	-1.4	1.9	1.7	-1.8
Bone: final moment	2.1	3.4	4.8	1.2	-1.6	2.1	2.0	-2.2
Food consumed during 24 hour testing period	1.2	1.6	3.2	1.8	-1.6	1.0	1.1	-0.3
Glucose	0.3	0.5	1.0	-1.0	0.9	-0.2	-0.6	0.4
Heart weight	0.1	0.2	0.3	0.5	-0.4	0.5	0.3	0.3
Delay discount hyperbolic model param	0.6	0.7	1.3	-1.1	1.1	-0.8	-0.7	0.2
Intermittent access intake day 1-15 change	0.9	1.9	4.3	0.2	-0.5	1.5	1.6	-2.1
Intermittent access intake escalation	0.7	1.4	3.8	-0.2	-0.2	1.2	1.3	-2.0
Intermittent access intake escalation 2	1.0	1.1	1.8	0.5	-0.8	1.2	1.1	-1.3
Intermitt. access day 1 inactive lever presses	1.9	7.0	10.7	3.3	-3.3	2.3	2.5	-1.6
Intermitt. access day 15 inactive lever presses	0.9	1.8	3.6	1.9	-1.7	1.1	1.2	-0.4
Intermitt. access escalation Index	0.1	0.2	0.4	0.6	-0.3	-0.4	-0.2	0.6
Intermittent access day 1 total infusions	1.2	2.0	4.6	0.6	0.1	-1.8	-1.3	2.1
Intermittent access day 15 total infusions	0.1	0.2	0.6	0.8	-0.4	-0.4	0.1	0.2
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.3	1.1	-0.6	-0.7	-0.2	1.0
Intermittent access total infusions	0.5	0.6	1.3	0.8	-0.3	-0.9	-0.5	1.1
Intermittent access day 1 locomotion	1.5	1.8	3.5	1.7	-0.9	-1.3	-0.7	1.9
Intermittent access day 15 total locomotion	0.3	0.5	1.4	1.2	-0.7	-0.4	0.2	0.4
Intermittent access total locomotion	0.9	1.1	2.5	0.6	-0.1	-1.4	-0.9	1.6
Intermittent access standard deviation	2.6	5.3	6.8	2.5	-2.6	2.1	2.3	-1.9
Left kidney weight	1.7	7.8	13.8	0.9	-1.5	3.5	3.1	-3.7
Right kidney weight	2.1	9.8	17.2	1.2	-2.0	3.8	3.4	-4.1
Cocaine induced anxiety	0.1	0.1	0.2	-0.4	0.3	0.1	-0.1	-0.3
Post-drug Anxiety	0.0	0.0	0.1	0.1	-0.2	-0.0	-0.3	0.2
Baseline Anxiety	0.3	0.4	1.0	1.0	-0.7	0.2	0.2	0.5
Tail length	4.4	17.3	21.2	3.2	-3.8	4.6	4.5	-4.6
Length with tail	6.0	26.1	34.1	3.8	-4.5	5.8	5.6	-5.5
Length without tail	2.5	8.1	12.5	1.4	-1.9	3.5	3.2	-3.5
Times rat made contact with spout	1.0	1.2	2.6	-1.6	1.5	-0.7	-0.8	-0.0
Lifetime Intake	0.5	0.6	1.4	0.4	0.1	-1.1	-0.7	1.2
Liver weight, left	0.6	0.9	1.2	-1.1	1.1	-0.8	-1.0	0.8
Liver weight, right	0.3	0.5	0.8	-0.7	0.7	-0.8	-0.9	0.7
Locomotor activity	0.6	0.9	1.3	-1.2	1.0	-0.7	-1.0	0.8
Locomotor testing distance	0.6	1.1	1.3	-1.1	1.1	-0.8	-1.1	1.0
Locomotor testing rearing	1.6	3.2	4.5	-1.9	2.1	-1.6	-1.7	1.5
Locomotion in novel chamber	0.2	0.2	0.5	0.1	-0.3	-0.7	-0.6	0.4
Locomotion in novel chamber post-restriction	0.5	0.8	1.9	1.4	-1.4	-0.1	-0.1	0.3
Fecal boli incidents, locomotor time 1	2.0	3.0	5.0	-0.8	0.9	-2.2	-2.0	2.1
Change in fecal boli incidents, locomotor task	0.4	0.4	1.2	-1.1	0.7	0.4	-0.2	-0.4
Time >=10cm from walls, locomotor time 1	0.0	0.0	0.1	-0.3	0.2	0.1	-0.2	0.1
Bouts of movement, locomotor time 1	1.7	2.0	4.8	2.2	-1.9	0.6	1.0	-0.3
Total resting periods, locomotor time 1	1.8	2.0	5.0	2.2	-2.0	0.5	0.9	-0.1
Rest time, locomotor task time 1	1.2	1.5	2.4	-0.3	0.4	-1.5	-1.6	1.6
Distance moved, locomotor task time 1	0.1	0.1	0.2	-0.3	0.4	0.2	0.3	-0.5
Vertical activity count, locomotor time 1	0.7	1.6	2.8	0.9	-0.9	1.6	1.7	-1.3
Time >=10cm from walls, locomotor time 2	0.9	1.4	2.4	-0.3	0.5	-1.5	-1.3	1.6
Bouts of movement, locomotor time 2	0.1	0.2	0.5	0.7	-0.5	0.3	0.1	0.2
Total resting periods, locomotor time 2	0.1	0.1	0.4	0.6	-0.4	0.1	-0.1	0.5
Rest time, locomotor task time 2	0.4	0.5	1.1	-0.1	0.2	-0.8	-0.8	1.1
Distance moved, locomotor task time 2	0.1	0.1	0.4	-0.5	0.6	-0.1	-0.1	-0.1
Vertical activity count, locomotor time 2	0.6	0.8	1.2	0.7	-0.6	1.0	1.1	-0.9
Light reinforcement 1	0.1	0.2	0.4	-0.1	0.4	-0.5	-0.3	0.7
Light reinforcement 2	2.1	3.3	3.9	-1.8	1.9	-1.9	-2.0	1.5
Bone: marrow area	1.4	3.2	3.7	1.6	-1.8	1.9	1.9	-1.6
Bone: maximum diameter	1.1	2.1	2.6	1.1	-1.3	1.6	1.6	-1.6
Bone: maximum force	2.7	4.7	6.1	1.6	-2.0	2.5	2.3	-2.4
Bone: maximum moment	3.1	5.5	7.0	1.7	-2.1	2.6	2.5	-2.6
Mean time between licks in bursts	0.1	0.1	0.4	0.6	-0.4	0.2	0.2	0.2
Mean num. licks in bursts	0.9	1.5	3.9	0.1	-0.6	1.3	1.1	-2.0
Cd content in liver	0.3	0.3	0.7	-0.9	0.8	-0.1	-0.4	0.1
Co content in liver	0.7	0.8	1.4	-1.2	1.1	-0.8	-0.8	0.4
Cu content in liver	0.9	1.1	2.0	0.6	-0.8	1.1	1.1	-1.4
Fe content in liver	0.3	0.4	0.5	-0.4	0.4	-0.7	-0.7	0.6
K content in liver	0.0	0.0	0.1	0.3	-0.3	0.1	0.1	0.2
Mg content in liver	0.7	0.7	0.9	-0.9	0.9	-0.8	-0.9	0.7
Mn content in liver	0.8	0.9	1.1	-1.1	0.9	-0.9	-1.0	0.9
Na content in liver	0.9	0.9	1.3	1.1	-1.1	0.9	1.0	-0.5
Rb content in liver	0.1	0.1	0.1	-0.3	0.3	-0.3	-0.4	0.3
Se content in liver	5.9	7.0	8.1	-2.8	2.8	-2.7	-2.9	2.1
Sr content in liver	0.3	0.3	0.5	-0.4	0.4	-0.4	-0.5	0.7
Zn content in liver	3.1	3.5	5.2	-2.3	2.2	-1.5	-1.8	1.2
Bone: minimum diameter	3.7	6.7	9.0	2.9	-3.0	2.3	2.7	-1.8
Time in familiar zone, hab. session 1	0.8	0.8	2.2	-1.0	0.4	0.6	0.4	-1.5
Time in novel zone, hab. session 1	1.2	1.2	3.8	0.3	0.3	-1.0	-1.0	1.9
Total zone transitions, hab. session 1	0.1	0.1	0.4	0.6	-0.4	-0.1	0.0	0.2
Total locomotion distance, hab. session 1	1.8	2.6	5.4	2.3	-2.1	1.2	1.3	-0.2
Locomotion velocity, hab. session 1	1.2	1.7	3.5	1.9	-1.7	0.9	1.0	-0.1
Time in familiar zone, hab. session 2	1.1	1.2	1.4	0.8	-1.2	1.1	1.2	-1.1
Time in novel zone, hab. session 2	0.8	0.8	1.0	-0.8	1.0	-0.9	-1.0	0.9
Total zone transitions, hab. session 2	2.4	3.1	4.9	-0.9	1.3	-2.0	-2.0	2.2
Total locomotion distance, hab. session 2	0.4	0.5	1.3	1.0	-0.5	-0.2	-0.3	1.2
Locomotion velocity, hab. session 2	0.3	0.4	1.3	0.7	-0.3	-0.4	-0.4	1.2
Novel to familiar place preference ratio	0.1	0.1	0.2	0.3	-0.3	0.5	0.4	-0.3
Novelty place preference	0.1	0.1	0.1	0.3	-0.2	0.3	0.4	-0.1
Time in novel zone, NPP test	0.0	0.0	0.0	0.2	-0.0	0.1	0.1	0.0
Total zone transitions, NPP test	0.0	0.0	0.1	-0.0	0.1	-0.3	-0.2	-0.0
Total locomotion distance, NPP test	2.7	3.7	4.7	2.1	-2.2	1.9	1.9	-1.5
Locomotion velocity, NPP test	2.8	3.9	5.1	2.1	-2.3	2.0	1.9	-1.5
Intraocular pressure	0.1	0.1	0.1	0.4	-0.3	-0.3	-0.1	0.2
Delta distance traveled before/after self-admin	1.7	1.8	3.7	0.2	-0.5	1.9	1.6	-1.6
Delta ambulatory time before/after self-admin	1.5	1.8	3.7	0.3	-0.4	1.9	1.6	-1.6
Parametrial fat weight	1.0	2.3	6.8	-2.6	2.0	-0.2	-0.9	-0.3
Pavlov. Cond. lever latency	0.3	0.4	0.7	-0.9	0.5	0.6	0.2	-0.8
Pavlov. Cond. magazine entry latency	0.6	0.8	2.3	0.2	0.2	-0.9	-0.9	1.5
Pavlov. Cond. change in total contacts	0.7	0.8	1.8	1.0	-0.4	-0.8	-0.4	1.3
Pavlov. Cond. index score	0.5	0.7	1.9	0.4	-0.0	-0.9	-0.7	1.4
Pavlov. Cond. latency score	0.4	0.6	1.4	0.8	-0.3	-0.8	-0.5	1.2
Pavlov. Cond. lever contacts	0.5	0.6	1.5	1.2	-0.9	-0.4	0.2	0.6
Pavlov. Cond. magazine entry number	0.5	0.6	1.7	-0.4	-0.1	0.7	0.7	-1.3
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.5	-1.1	1.1	-1.2	-1.0	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	2.5	0.3	0.2	-1.0	-0.9	1.6
Pavlov. Cond. response bias	0.3	0.4	1.0	0.3	0.0	-0.6	-0.6	1.0
Pavlov. Cond. lever latency	5.2	7.1	8.4	-2.6	2.8	-2.9	-2.8	2.2
Pavlov. Cond. magazine entry latency	3.7	4.5	5.9	2.4	-2.4	2.1	2.1	-1.4
Pavlov. Cond. change in total contacts	7.4	11.9	13.3	3.4	-3.6	3.6	3.6	-2.9
Pavlov. Cond. index score	6.1	8.1	9.5	2.9	-3.0	3.1	3.0	-2.3
Pavlov. Cond. latency score	5.5	7.3	8.7	2.9	-3.0	2.9	2.8	-1.9
Pavlov. Cond. lever contacts	5.6	7.7	8.9	2.7	-2.8	3.0	2.9	-2.4
Pavlov. Cond. magazine entry number	4.3	5.3	7.0	-2.1	2.2	-2.6	-2.4	2.1
Pavlov. Cond. intertrial magazine entries	1.2	1.7	2.2	-1.5	1.5	-1.4	-1.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	5.6	7.5	9.1	2.7	-2.9	3.0	2.8	-2.2
Pavlov. Cond. response bias	6.6	9.0	10.7	2.9	-3.0	3.3	3.2	-2.6
Time in closed arm before self-admin	0.8	1.1	2.1	-0.2	0.6	-1.2	-1.2	1.4
Time in closed arm after self-admin	0.8	0.9	2.1	1.5	-1.4	0.5	0.3	-0.1
Time in open arm before self-admin	3.5	3.8	5.4	1.4	-1.8	2.3	2.1	-2.1
Time in open arm after self-admin	0.3	0.4	0.8	-0.3	0.1	0.7	0.9	-0.7
Bone: periosteal estimation	2.0	4.2	5.0	1.6	-2.0	2.2	2.2	-2.1
Bone: periosteal perimeter	1.3	2.2	3.0	1.5	-1.7	1.3	1.5	-1.3
Bone: post-yield work	2.5	3.6	4.8	2.2	-2.2	1.7	2.0	-1.3
Progressive ratio test 1 active lever presses	0.5	0.6	1.9	1.4	-1.0	-0.1	0.3	0.4
Progressive ratio test 1 breakpoint	0.7	0.8	2.5	1.6	-1.1	-0.0	0.4	0.4
Progressive ratio test 1 inactive lever presses	1.4	2.0	5.8	2.4	-1.8	-0.0	0.7	0.5
Progressive ratio test 2 active lever presses	0.2	0.2	0.5	0.3	-0.1	-0.7	-0.3	0.4
Progressive ratio test 2 breakpoint	0.2	0.3	0.7	0.3	-0.0	-0.8	-0.5	0.6
Progressive ratio test 2 inactive lever presses	1.4	2.2	5.9	2.4	-2.1	0.1	0.8	-0.1
Incentive Sensitization - Responses	0.3	0.5	1.2	-0.4	0.5	-1.1	-0.7	0.5
Incentive Sensitization - Breakpoint	0.3	0.5	1.1	-0.5	0.5	-1.0	-0.7	0.4
Sum of active levers in priming session hrs 5-6	0.0	0.0	0.1	-0.1	0.0	-0.3	-0.2	-0.0
Progressive ratio	0.4	0.7	1.5	1.2	-1.0	-0.2	-0.0	0.9
Food seeking constrained by brief footshock	3.3	4.1	6.7	2.6	-2.6	1.6	1.9	-1.0
Seeking ratio, punishment vs. effort	0.4	0.6	0.8	0.6	-0.6	0.9	0.8	-0.8
Retroperitoneal fat weight	1.2	5.1	12.0	-3.5	2.9	-1.0	-1.9	0.6
Reaction time number correct	0.2	0.3	0.7	-0.9	0.8	0.1	-0.1	-0.3
Reaction time mean minus median	0.2	0.4	0.8	-0.1	-0.0	0.9	0.7	-0.9
Reaction time mean minus median AUC	0.4	1.0	1.9	-0.4	0.1	1.4	1.0	-1.4
Reaction time num false alarms	0.9	1.3	1.8	-1.2	1.4	-1.0	-1.0	0.9
Reaction time num false alarms AUC	1.0	1.6	1.9	-1.2	1.4	-1.2	-1.2	1.2
Reaction time trials correct on left	0.2	0.3	0.7	-0.9	0.8	0.1	-0.1	-0.3
Reaction time trials on left	0.2	0.4	0.9	-0.9	0.9	0.1	-0.1	-0.4
Reaction time mean	0.2	0.2	0.5	-0.3	0.3	0.7	0.5	-0.6
Reaction time mean AUC	0.1	0.2	0.4	-0.4	0.3	0.6	0.4	-0.4
Median of all reaction times	0.1	0.1	0.2	-0.4	0.4	0.2	0.1	-0.0
Reaction time omissions	0.4	0.6	1.6	-1.3	1.1	0.0	-0.2	-0.2
Reaction time false alarm rate	0.5	0.7	1.1	-0.5	0.6	-1.0	-0.9	1.1
Reaction time premature initiation rate	0.4	0.6	1.4	1.2	-0.8	0.2	0.2	0.9
Reaction time premature initiations	0.1	0.2	0.5	0.6	-0.3	0.2	0.1	0.7
Std. dev. reaction times	0.4	0.8	1.6	-0.1	-0.0	1.3	1.0	-1.1
Reaction time trials completed	0.2	0.4	0.9	-0.9	0.9	0.1	-0.1	-0.4
Reaction time trials AUC	0.3	0.6	1.5	-1.2	1.1	-0.0	-0.3	-0.4
Run reversals in cocaine runway, females	0.5	0.5	1.1	0.1	-0.1	0.8	0.9	-1.0
Run reversals in cocaine runway, males	1.3	1.3	3.8	-2.0	1.5	0.1	-0.6	-0.2
Latency to leave start box in cocaine runway	0.2	0.2	0.6	-0.0	0.1	0.4	0.5	-0.7
Latency to leave start box in cocaine runway, F	0.1	0.1	0.3	-0.4	0.5	0.0	0.2	-0.2
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	0.2	-0.2	0.2	0.3	-0.4
Std. dev. time between licks in bursts	1.3	1.8	4.7	2.2	-1.7	0.4	0.6	1.0
Total sessions with >9 infusions	0.9	1.1	1.4	-0.8	1.1	-1.2	-1.1	1.1
Short access day 1 total inactive lever presses	1.5	1.9	5.1	2.3	-1.8	0.4	1.0	-0.2
Short access day 10 total inactive lever presses	2.1	5.1	9.4	3.1	-3.0	1.2	2.0	-1.3
Short access day 1 total infusions	0.1	0.1	0.2	0.4	-0.2	-0.3	-0.0	0.4
Short access day 10 total infusions	0.2	0.3	0.6	0.2	0.1	-0.7	-0.5	0.8
Short access total infusions	0.5	0.7	1.2	-0.2	0.5	-1.0	-0.9	1.1
Short access day 1 locomotion	1.0	1.2	1.8	-1.1	1.3	-0.9	-1.0	1.0
Short access day 10 total locomotion	1.5	2.9	7.9	2.8	-2.3	0.3	0.9	0.5
Short access total locomotion	0.9	1.1	3.0	0.3	0.2	-1.2	-1.0	1.7
One hour access (0.3 mA shock)	1.9	2.1	5.7	2.4	-1.9	0.5	1.0	0.0
Compulsive drug intake	0.2	0.2	0.7	0.8	-0.5	0.0	0.2	0.4
One hour access (shock baseline)	0.4	0.6	1.7	1.3	-1.0	-0.1	0.2	0.3
Social response proportion	2.0	2.3	3.7	1.7	-1.9	1.1	1.4	-1.4
Social responses	0.5	0.7	1.5	1.1	-1.2	0.1	0.7	-0.4
Social time	2.6	3.6	4.4	2.0	-2.1	1.5	2.0	-1.7
Soleus weight	0.1	0.3	0.9	-0.9	0.7	-0.2	-0.4	-0.1
Bone: stiffness	1.4	2.3	3.3	1.1	-1.4	1.7	1.5	-1.8
Tibialis anterior weight	0.5	1.8	4.9	-2.2	1.7	-0.2	-0.6	-0.9
Time to tail flick, vehicle, before self-admin	0.2	0.2	0.4	-0.2	0.5	-0.5	-0.4	0.6
Time to tail flick, vehicle, after self-admin	1.1	1.5	3.6	1.9	-1.8	0.4	0.5	0.2
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.0	0.3	0.3	0.1	-0.2
Time to tail flick, test, after self-admin	0.1	0.1	0.1	0.0	0.0	-0.3	-0.3	0.4
Delta time to tail flick, vehicle, before/after SA	1.1	1.0	1.6	1.3	-1.3	1.0	0.9	-0.3
Delta time to tail flick, test, before/after SA	0.5	0.5	0.8	-0.5	0.4	-0.9	-0.8	0.8
Tibia length	2.5	6.8	10.2	1.7	-2.1	3.2	2.7	-3.0
Ambulatory time before self-admin	1.0	1.4	3.8	1.9	-1.8	0.1	0.4	0.1
Ambulatory time after self-admin	4.6	5.4	6.4	2.4	-2.5	2.4	2.4	-1.9
Bone: tissue strength	3.2	3.3	3.7	1.7	-1.8	1.9	1.9	-1.6
Total heroin consumption	0.8	0.9	2.1	1.5	-1.3	0.3	0.7	-0.3
Bone: trabecular number	1.3	2.2	3.7	1.0	-1.2	1.9	1.5	-1.6
Bone: trabecular spacing	0.1	0.2	0.3	0.4	-0.5	0.4	0.5	-0.0
Bone: trabecular thickness	0.2	0.3	0.6	-0.8	0.7	0.1	-0.2	-0.5
Bone: trabecular tissue density	2.4	3.5	6.5	-2.5	2.3	-1.4	-1.8	0.8
Water consumed over 24 hours	0.4	0.5	0.9	0.4	-0.5	0.9	0.7	-1.0
Number of responses in last shaping day	0.5	0.5	1.4	1.2	-0.9	0.2	0.5	0.0