LOC108349559

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	XR_005493975.1	0.06	0.05	3.8e-05	0.03	0.03	0.04	0.03	4.2e-04	3.0e-04	8.0e-05	8.4e-04
2	Adipose	alternative polyA	XR_005493969.1	0.06	0.05	2.8e-06	0.04	0.04	0.04	0.03	4.9e-05	8.7e-05	4.3e-05	1.0e-04
3	PL	gene expression	LOC108349559	0.03	0.02	5.5e-05	0.04	0.03	0.02	0.03	6.6e-05	3.5e-04	2.1e-03	4.3e-04
4	PL	alternative polyA	XR_005493969.1	0.03	0.02	1.8e-03	0.03	0.02	0.02	0.03	3.1e-04	2.1e-03	2.1e-03	6.7e-04
5	Adipose	gene expression	LOC108349559	0.13	0.11	8.8e-11	0.07	0.07	0.07	0.07	4.2e-08	2.1e-08	1.2e-08	2.2e-08

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5
Bone: apparent density	0.5	0.8	1.9	0.0	0.3	-1.4	1.1	-0.9
Area under the delay curve	0.8	0.8	1.6	-1.3	1.2	-0.7	0.6	-0.4
BMI with tail	0.2	0.6	1.0	1.0	-1.0	0.8	-0.2	0.7
BMI without tail	0.0	0.0	0.1	-0.1	0.2	-0.4	0.2	0.0
Body weight	2.3	9.5	14.9	-1.7	2.2	-3.5	3.9	-3.5
Weight adjusted by age	0.6	0.7	1.3	1.1	-1.0	-0.6	0.9	-0.5
Bone surface	1.7	2.9	3.7	-1.5	1.6	-1.9	1.7	-1.8
Bone volume	1.4	2.5	3.7	-1.0	1.2	-1.9	1.6	-1.8
Breakpoint value in progressive ratio session	2.9	3.2	6.9	-2.6	2.5	-0.9	1.2	-0.8
Number of licking bursts	1.9	2.2	3.1	1.1	-1.6	1.8	-1.7	1.1
Context. condit. distance diff. score	0.1	0.1	0.3	-0.2	0.1	0.2	0.5	-0.3
Locomotion velocity, session 1	0.6	0.7	0.9	0.9	-0.9	0.7	-0.9	0.5
Locomotion distance, session 1	0.8	1.0	1.6	-1.1	1.0	-0.7	0.7	-1.3
Locomotion velocity, session 2	0.8	1.0	3.0	-0.1	-0.1	1.1	-1.7	0.6
Locomotion distance, session 2	0.6	0.9	2.0	0.2	-0.5	1.4	-1.4	0.6
Locomotion velocity, session 3	0.2	0.2	0.5	0.3	-0.5	0.7	-0.7	0.0
Locomotion distance, session 3	3.9	4.2	6.7	-2.6	2.4	-1.3	1.5	-2.2
Stereotopy head waving bouts, day 3	1.3	1.6	2.4	1.5	-1.3	0.7	-1.0	1.6
Stereotopy head waving duration, day 3	2.3	2.8	4.6	1.9	-1.7	1.0	-1.4	2.1
Locomotion velocity, session 7	0.6	0.7	1.0	-1.0	0.9	-0.5	0.8	-1.0
Locomotion distance, session 7	0.2	0.3	0.9	-0.5	0.5	-0.2	0.3	-0.9
Stereotopy head waving bouts, day 7	0.5	0.5	1.2	0.2	-0.5	0.8	-1.1	0.7
Stereotopy head waving duration, day 7	1.8	2.2	2.7	1.3	-1.5	1.5	-1.4	1.6
Locomotion velocity, session 8	2.4	2.9	5.2	1.1	-1.5	2.3	-1.9	1.5
Locomotion distance, session 8	0.3	0.4	1.4	-0.3	-0.1	1.2	-0.7	0.0
Degree of sensitization distance	0.8	0.8	1.5	1.2	-1.1	0.5	-0.7	0.7
Degree of sensitization stereotypy	0.5	0.5	1.1	0.2	-0.5	0.9	-1.0	0.6
Conditioned locomotion	0.4	0.5	1.3	0.2	-0.3	0.8	-0.8	1.1
Cocaine response after cond. corrected	0.4	0.5	1.1	1.0	-0.8	0.4	-0.1	0.8
Cocaine response after cond. not corrected	0.4	0.4	0.9	1.0	-0.7	0.2	-0.2	0.7
Cocaine response before conditioning	1.4	1.7	2.4	-1.4	1.4	-1.4	0.4	-1.5
Saline control response	0.0	0.0	0.1	0.1	-0.0	0.2	-0.3	0.2
Bone: connectivity density	0.2	0.3	0.6	-0.4	0.5	-0.8	0.4	-0.5
Bone: cortical apparent density	1.4	1.8	2.8	1.3	-1.5	1.7	-1.0	1.2
Bone: cortical area	1.0	1.5	1.9	-1.0	1.1	-1.3	1.3	-1.4
Bone: cortical porosity	1.0	1.1	3.8	-0.1	-0.3	1.1	-1.9	0.7
Bone: cortical porosity	1.3	1.4	4.4	-0.1	-0.5	1.3	-2.1	0.7
Bone: cortical thickness	0.2	0.3	0.5	-0.2	0.4	-0.6	0.7	-0.6
Bone: cortical thickness	0.9	1.1	1.5	1.2	-1.2	0.8	-0.8	1.0
Bone: cortical tissue density	1.6	2.1	3.3	1.4	-1.6	1.8	-1.1	1.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	0.3	-0.4	0.4	-0.3	0.5
Condit. Reinf. active-inactive response ratio	0.6	0.7	1.4	1.1	-0.9	0.2	-0.2	1.2
Condit. Reinf. active responses	1.4	1.8	2.6	0.9	-1.1	1.6	-1.3	1.6
Condit. Reinf. inactive responses	1.2	1.5	3.4	0.2	-0.6	1.8	-1.5	1.1
Incentive salience index mean	0.1	0.2	0.3	0.0	-0.1	0.5	-0.5	0.5
Condit. Reinf. lever presses	0.2	0.2	0.6	-0.8	0.6	0.2	-0.4	-0.0
Condit. Reinf. active minus inactive responses	1.3	1.6	3.0	-1.7	1.7	-0.9	0.6	-1.1
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.2	0.3	-0.3	0.5	-0.2	0.0
Condit. Reinf. active responses	3.4	4.8	7.2	-2.7	2.7	-1.9	1.3	-2.1
Condit. Reinf. inactive responses	5.1	6.3	10.1	-3.2	3.1	-2.2	1.4	-2.3
Condit. Reinf. lever presses	6.3	8.5	10.7	-3.0	3.3	-3.1	2.5	-2.6
Condit. Reinf. lever reinforcers received	3.9	5.4	8.1	-2.8	2.8	-2.0	1.4	-2.3
Conditioned reinforcement - actives	0.2	0.2	0.8	-0.3	0.1	0.3	-0.9	-0.3
Conditioned reinforcement - inactives	1.7	1.9	4.6	-2.1	1.7	-0.8	0.4	-1.1
Conditioned locomotion	1.1	1.3	2.7	0.3	-0.7	1.6	-1.6	1.0
Patch foraging indifference point 0 sec	0.1	0.2	0.4	-0.7	0.6	-0.2	-0.3	-0.1
Patch foraging indifference point AUC	0.5	0.6	0.9	0.9	-0.9	0.6	-0.5	0.7
Delay disc. indifference point, 0s delay	0.9	1.0	1.8	-1.3	1.1	-0.3	1.1	-0.7
Delay disc. indifference point, 16s delay	1.8	1.8	4.0	-2.0	1.9	-1.0	0.6	-0.5
Delay disc. indifference point, 2s delay	1.5	1.7	2.3	-1.3	1.3	-1.1	1.5	-1.3
Delay disc. indifference point, 24s delay	2.4	2.3	2.7	-1.6	1.6	-1.4	1.5	-1.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.6	-0.8	0.6	-0.0	-0.5	-0.1
Delay disc. indifference point, 8s delay	0.3	0.3	0.4	-0.6	0.6	-0.7	0.5	-0.6
Indifference point function ln k	0.5	0.7	1.2	-1.1	1.1	-0.6	0.4	-0.6
Indifference point function log k	0.5	0.7	1.2	-1.1	1.1	-0.6	0.4	-0.6
Patch foraging total patch changes 0 sec	0.2	0.3	0.8	-0.9	0.8	-0.4	-0.2	-0.4
Patch foraging total patch changes 12 sec	0.2	0.2	0.4	-0.5	0.4	0.0	-0.6	0.4
Patch foraging total patch changes 18 sec	0.1	0.1	0.3	-0.0	-0.1	0.0	-0.2	-0.5
Patch foraging total patch changes 24 sec	1.0	1.2	2.0	-0.9	0.8	-1.1	1.2	-1.4
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	0.1	-0.1	-0.0	-0.5	0.0
Patch foraging time to switch 0 sec	0.6	0.9	1.7	0.5	-0.5	1.0	-1.1	1.3
Patch foraging water rate 0 sec	0.6	1.0	1.2	0.9	-1.1	1.0	-1.0	0.8
Patch foraging water rate 12 sec	0.7	1.1	2.8	-0.8	0.6	-1.3	0.1	-1.7
Patch foraging water rate 18 sec	0.2	0.3	1.0	0.3	-0.4	-0.0	-1.0	0.4
Patch foraging water rate 24 sec	0.4	0.5	1.3	-1.1	0.8	-0.2	0.1	-0.8
Patch foraging water rate 6 sec	1.2	1.7	2.7	-1.4	1.2	-1.4	0.8	-1.7
Seeking ratio, delayed vs. immediate footshock	2.0	2.3	3.0	-1.7	1.6	-1.3	1.1	-1.6
Distance traveled before self-admin	0.6	0.6	1.5	-1.2	1.1	0.1	-0.4	-0.3
Distance traveled after self-admin	5.1	5.6	7.5	-2.7	2.7	-2.3	1.5	-2.3
Extensor digitorum longus weight	0.6	2.3	5.7	2.4	-2.0	0.5	0.6	1.1
Bone: elastic displacement	0.0	0.0	0.0	0.1	-0.1	-0.1	-0.1	-0.1
Bone: elastic work	1.7	2.2	3.1	-1.1	1.3	-1.8	1.6	-1.5
Bone: endosteal estimation	1.5	3.3	3.8	-1.8	1.9	-1.9	1.6	-1.8
Bone: endosteal perimeter	1.6	3.2	4.4	-2.1	2.1	-1.6	1.3	-1.8
Epididymis fat weight	0.2	0.4	0.7	-0.2	0.2	-0.6	0.8	-0.8
Delta time in closed arm before/after self-admin	2.4	2.3	4.3	-0.7	1.0	-1.9	2.1	-1.5
Delta time in open arm before/after self-admin	1.4	1.4	1.9	1.3	-1.4	1.1	-1.2	0.8
Diff in mean of infusions in LGA sessions	0.6	0.7	0.9	-1.0	0.8	1.0	-0.5	0.9
Delay discount exponential model param	0.8	0.8	1.4	1.2	-1.1	0.8	-0.7	0.5
Extinction: sum of active levers before priming	2.7	2.6	4.5	-1.2	1.5	-1.7	2.1	-1.5
Active lever presses in extinction session 6	1.7	1.6	2.3	-1.1	1.5	-1.4	1.2	-1.1
Bone: final force	1.6	2.5	4.1	-1.2	1.4	-1.7	2.0	-1.5
Bone: final moment	2.0	3.2	5.2	-1.3	1.5	-1.9	2.3	-1.8
Food consumed during 24 hour testing period	1.4	1.7	3.3	-1.8	1.6	-1.0	0.6	-1.2
Glucose	0.2	0.3	0.8	0.9	-0.8	0.1	-0.4	0.1
Heart weight	0.3	0.4	0.6	-0.6	0.6	-0.5	0.8	-0.7
Delay discount hyperbolic model param	0.6	0.7	1.1	1.1	-1.0	0.8	-0.7	0.5
Intermittent access intake day 1-15 change	1.8	1.8	3.3	-0.5	0.7	-1.4	1.8	-1.7
Intermittent access intake escalation	1.9	1.9	3.7	-0.6	0.8	-1.4	1.9	-1.7
Intermittent access intake escalation 2	1.3	1.2	1.6	-0.9	1.0	-1.2	1.2	-1.2
Intermitt. access day 1 inactive lever presses	2.9	3.2	4.0	-1.8	2.0	-2.0	1.8	-1.2
Intermitt. access day 15 inactive lever presses	0.6	0.6	1.2	-1.1	1.0	-0.6	0.6	-0.4
Intermitt. access escalation Index	0.0	0.0	0.1	-0.2	0.0	0.4	-0.0	-0.0
Intermittent access day 1 total infusions	1.0	1.1	2.9	-0.2	-0.4	1.5	-1.7	0.6
Intermittent access day 15 total infusions	0.5	0.6	1.6	-1.3	0.8	0.1	-0.1	-0.8
Intermittent access terminal intake (last 3 days)	0.5	0.6	1.6	-1.3	0.8	0.5	-0.7	-0.3
Intermittent access total infusions	0.6	0.6	1.3	-1.2	0.6	0.6	-1.0	-0.2
Intermittent access day 1 locomotion	0.7	0.7	1.3	-1.0	0.4	1.0	-1.2	0.3
Intermittent access day 15 total locomotion	0.4	0.5	1.1	-1.1	0.7	0.3	-0.0	-0.8
Intermittent access total locomotion	0.6	0.7	1.8	-0.5	0.0	1.1	-1.4	0.4
Intermittent access standard deviation	6.2	6.6	7.9	-2.8	2.8	-2.4	2.1	-2.7
Left kidney weight	1.9	5.4	11.9	-0.3	1.0	-2.8	3.4	-2.6
Right kidney weight	3.7	10.3	17.4	-1.5	2.2	-3.9	4.2	-3.4
Cocaine induced anxiety	0.4	0.4	0.7	-0.4	0.6	-0.8	0.9	-0.3
Post-drug Anxiety	0.2	0.2	0.9	0.2	-0.0	0.0	-0.2	1.0
Baseline Anxiety	1.0	1.0	1.7	0.6	-0.8	1.1	-1.3	1.1
Tail length	3.7	11.1	17.0	-2.6	3.0	-4.1	3.2	-3.5
Length with tail	6.8	24.9	31.8	-3.9	4.5	-5.6	5.2	-5.5
Length without tail	4.7	10.3	14.2	-2.2	2.5	-3.5	3.7	-3.8
Times rat made contact with spout	0.9	1.1	2.5	1.6	-1.5	0.5	-0.4	0.5
Lifetime Intake	0.4	0.4	1.1	-0.6	0.2	0.7	-1.1	-0.1
Liver weight, left	0.8	1.3	2.8	1.7	-1.5	0.6	-0.3	0.9
Liver weight, right	0.2	0.4	0.5	0.6	-0.6	0.3	-0.7	0.7
Locomotor activity	0.7	1.0	1.8	0.9	-0.8	0.8	-1.3	1.1
Locomotor testing distance	0.4	0.7	1.9	0.8	-0.7	0.6	-1.4	0.7
Locomotor testing rearing	1.9	2.9	3.9	1.8	-2.0	1.6	-1.8	1.1
Locomotion in novel chamber	0.4	0.5	1.3	-0.2	0.2	0.8	-0.7	1.1
Locomotion in novel chamber post-restriction	0.7	0.8	1.7	-1.3	1.3	0.1	-0.4	0.8
Fecal boli incidents, locomotor time 1	1.8	2.0	3.6	0.5	-0.6	1.9	-1.7	1.7
Change in fecal boli incidents, locomotor task	0.2	0.2	0.5	0.7	-0.4	-0.6	0.0	0.5
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.4	-0.3	-0.1	-0.1	0.4
Bouts of movement, locomotor time 1	1.8	2.0	4.3	-2.1	1.8	-0.5	0.6	-1.3
Total resting periods, locomotor time 1	1.8	2.0	4.6	-2.1	1.9	-0.4	0.4	-1.0
Rest time, locomotor task time 1	0.9	1.0	2.1	0.3	-0.3	1.2	-1.1	1.5
Distance moved, locomotor task time 1	0.2	0.2	0.4	0.4	-0.4	-0.2	0.6	-0.6
Vertical activity count, locomotor time 1	1.5	1.6	2.8	-0.7	0.8	-1.5	1.3	-1.7
Time >=10cm from walls, locomotor time 2	1.3	1.4	2.6	0.5	-0.7	1.6	-1.3	1.4
Bouts of movement, locomotor time 2	0.2	0.2	0.5	-0.7	0.5	-0.3	-0.3	-0.5
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.6	0.4	-0.1	-0.6	-0.2
Rest time, locomotor task time 2	0.6	0.7	1.7	0.1	-0.2	0.9	-1.3	1.1
Distance moved, locomotor task time 2	0.2	0.2	0.5	0.6	-0.7	0.0	0.4	-0.5
Vertical activity count, locomotor time 2	1.0	1.1	2.0	-0.5	0.6	-1.1	1.3	-1.4
Light reinforcement 1	0.1	0.3	1.0	-0.2	-0.1	0.5	-1.0	-0.1
Light reinforcement 2	2.4	3.3	5.0	1.5	-1.7	1.9	-1.7	2.2
Bone: marrow area	1.5	3.3	4.0	-1.8	2.0	-2.0	1.6	-1.8
Bone: maximum diameter	1.0	1.9	2.7	-1.1	1.3	-1.6	1.4	-1.4
Bone: maximum force	2.6	4.5	6.9	-1.6	1.8	-2.3	2.6	-2.0
Bone: maximum moment	3.0	5.2	8.0	-1.7	2.0	-2.4	2.8	-2.3
Mean time between licks in bursts	0.1	0.1	0.2	-0.4	0.3	-0.1	-0.3	0.3
Mean num. licks in bursts	0.6	0.8	1.7	0.0	0.4	-1.2	1.3	-0.7
Cd content in liver	0.2	0.2	0.5	0.1	-0.1	-0.5	0.3	-0.7
Co content in liver	0.6	0.7	1.0	1.0	-0.9	0.7	-0.2	1.0
Cu content in liver	0.4	0.5	0.8	-0.3	0.4	-0.9	0.9	-0.7
Fe content in liver	0.0	0.0	0.2	-0.2	0.1	0.1	-0.4	0.1
K content in liver	0.1	0.1	0.3	-0.3	0.2	-0.1	-0.5	0.3
Mg content in liver	1.0	1.0	2.0	0.8	-0.8	0.8	-1.1	1.4
Mn content in liver	1.4	1.6	2.5	1.1	-1.1	1.0	-1.6	1.5
Na content in liver	1.8	1.9	2.8	-1.7	1.6	-1.2	0.6	-1.5
Rb content in liver	0.1	0.1	0.4	0.1	-0.2	0.4	0.3	0.7
Se content in liver	7.8	9.6	11.4	3.0	-3.1	3.2	-2.7	3.4
Sr content in liver	0.9	0.8	1.6	0.7	-0.8	0.8	-1.3	0.9
Zn content in liver	0.2	0.2	0.4	0.6	-0.6	0.4	-0.1	0.6
Bone: minimum diameter	3.4	6.3	8.2	-2.9	2.9	-2.3	1.8	-2.5
Time in familiar zone, hab. session 1	0.5	0.5	1.4	0.8	-0.4	-0.5	1.2	-0.2
Time in novel zone, hab. session 1	1.1	1.0	3.3	-0.3	-0.2	1.0	-1.8	0.9
Total zone transitions, hab. session 1	0.1	0.2	0.4	-0.6	0.5	0.1	-0.1	-0.4
Total locomotion distance, hab. session 1	1.8	2.5	5.2	-2.3	2.1	-1.2	-0.1	-1.2
Locomotion velocity, hab. session 1	1.1	1.6	3.4	-1.8	1.7	-0.9	-0.3	-0.9
Time in familiar zone, hab. session 2	0.9	0.9	1.4	-0.9	1.2	-1.2	0.9	-0.3
Time in novel zone, hab. session 2	0.7	0.7	1.0	0.8	-1.0	0.9	-0.9	0.4
Total zone transitions, hab. session 2	2.3	2.9	5.0	1.0	-1.3	2.0	-2.2	1.7
Total locomotion distance, hab. session 2	0.3	0.5	1.1	-0.9	0.5	0.2	-1.0	0.3
Locomotion velocity, hab. session 2	0.3	0.4	1.2	-0.6	0.3	0.4	-1.1	0.5
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.3	0.3	-0.4	0.6	-0.4
Novelty place preference	0.1	0.1	0.2	-0.2	0.2	-0.3	0.5	-0.5
Time in novel zone, NPP test	0.1	0.1	0.1	-0.1	0.0	-0.1	0.4	-0.3
Total zone transitions, NPP test	0.0	0.0	0.1	0.0	-0.1	0.3	-0.2	-0.2
Total locomotion distance, NPP test	2.4	3.3	4.4	-2.0	2.1	-1.8	1.0	-1.9
Locomotion velocity, NPP test	2.4	3.4	4.8	-2.1	2.2	-2.0	0.8	-1.8
Intraocular pressure	0.0	0.1	0.1	-0.3	0.3	0.2	0.1	0.1
Delta distance traveled before/after self-admin	4.0	4.3	6.0	-1.5	1.7	-2.5	2.3	-2.2
Delta ambulatory time before/after self-admin	4.4	4.8	7.0	-1.6	1.7	-2.6	2.4	-2.5
Parametrial fat weight	1.2	2.4	6.0	2.5	-2.0	-0.1	0.2	1.4
Pavlov. Cond. lever latency	0.5	0.6	2.2	0.5	-0.2	-0.8	1.5	-0.3
Pavlov. Cond. magazine entry latency	0.8	1.0	4.4	-0.3	-0.1	0.7	-2.1	0.4
Pavlov. Cond. change in total contacts	0.8	0.8	2.5	-0.9	0.5	0.8	-1.6	-0.0
Pavlov. Cond. index score	1.0	1.2	4.9	-0.3	-0.0	0.9	-2.2	0.6
Pavlov. Cond. latency score	0.7	0.9	3.5	-0.6	0.3	0.8	-1.9	0.4
Pavlov. Cond. lever contacts	0.6	0.7	1.2	-1.1	0.9	0.4	-1.1	0.0
Pavlov. Cond. magazine entry number	0.9	1.1	4.5	0.3	0.1	-0.7	2.1	-0.5
Pavlov. Cond. intertrial magazine entries	0.7	0.9	1.4	1.0	-1.0	1.2	-0.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.2	1.4	5.7	-0.3	-0.1	1.0	-2.4	0.6
Pavlov. Cond. response bias	0.6	0.8	3.2	-0.4	0.1	0.5	-1.8	0.3
Pavlov. Cond. lever latency	4.7	6.4	7.1	2.5	-2.7	2.6	-2.3	2.5
Pavlov. Cond. magazine entry latency	2.7	3.2	4.8	-2.2	2.2	-1.8	1.0	-1.5
Pavlov. Cond. change in total contacts	8.1	11.2	12.3	-3.4	3.5	-3.4	3.0	-3.4
Pavlov. Cond. index score	5.0	6.4	7.7	-2.7	2.8	-2.7	2.0	-2.5
Pavlov. Cond. latency score	4.8	6.0	7.5	-2.7	2.7	-2.5	1.8	-2.4
Pavlov. Cond. lever contacts	4.4	6.0	6.9	-2.4	2.5	-2.6	2.2	-2.5
Pavlov. Cond. magazine entry number	3.7	4.6	5.9	2.0	-2.1	2.4	-1.8	2.3
Pavlov. Cond. intertrial magazine entries	1.1	1.4	2.0	1.4	-1.4	1.3	-0.7	1.1
Pavlov. Cond. lever-magazine prob. diff.	4.7	6.0	7.2	-2.5	2.6	-2.7	1.9	-2.4
Pavlov. Cond. response bias	5.1	7.0	7.9	-2.6	2.7	-2.8	2.3	-2.8
Time in closed arm before self-admin	1.3	1.4	2.4	0.7	-1.0	1.5	-1.6	1.1
Time in closed arm after self-admin	0.4	0.4	0.8	-0.8	0.9	-0.6	0.6	-0.1
Time in open arm before self-admin	3.4	3.7	5.3	-1.8	2.0	-2.3	1.6	-1.7
Time in open arm after self-admin	0.4	0.4	1.2	-0.3	0.2	-0.8	0.3	-1.1
Bone: periosteal estimation	1.8	3.7	4.5	-1.7	1.9	-2.1	1.9	-2.0
Bone: periosteal perimeter	1.1	1.8	2.7	-1.5	1.6	-1.3	0.9	-1.3
Bone: post-yield work	2.3	3.1	3.8	-2.0	1.9	-1.5	1.7	-1.7
Progressive ratio test 1 active lever presses	1.7	1.8	3.7	-1.9	1.6	-0.6	0.4	-1.4
Progressive ratio test 1 breakpoint	2.1	2.2	4.2	-2.0	1.8	-0.9	0.6	-1.5
Progressive ratio test 1 inactive lever presses	1.3	1.4	3.4	-1.8	1.5	-0.5	0.6	-0.9
Progressive ratio test 2 active lever presses	0.9	0.9	2.3	-1.5	1.2	0.0	-0.3	-1.0
Progressive ratio test 2 breakpoint	0.8	0.8	2.1	-1.4	1.1	0.1	-0.4	-0.9
Progressive ratio test 2 inactive lever presses	3.1	3.6	9.3	-3.0	2.7	-0.4	0.8	-1.0
Incentive Sensitization - Responses	0.2	0.2	0.4	-0.6	0.4	0.5	-0.3	-0.4
Incentive Sensitization - Breakpoint	0.1	0.1	0.2	-0.4	0.3	0.4	-0.2	-0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.4	-0.6	0.6	-0.3	0.6	-0.3
Progressive ratio	0.4	0.4	1.0	-1.0	0.8	0.1	-0.7	-0.1
Food seeking constrained by brief footshock	3.4	4.2	6.9	-2.6	2.6	-1.8	1.0	-1.9
Seeking ratio, punishment vs. effort	0.5	0.7	0.8	-0.7	0.8	-0.9	0.8	-0.8
Retroperitoneal fat weight	1.7	5.6	10.2	3.2	-3.1	1.8	-1.2	2.0
Reaction time number correct	0.2	0.3	0.7	0.9	-0.8	-0.2	0.2	0.1
Reaction time mean minus median	0.3	0.4	0.8	-0.1	0.2	-0.9	0.9	-0.8
Reaction time mean minus median AUC	0.7	0.9	1.8	0.2	-0.0	-1.3	1.2	-1.1
Reaction time num false alarms	0.8	1.1	1.8	1.2	-1.3	1.0	-0.8	0.8
Reaction time num false alarms AUC	0.9	1.3	1.7	1.2	-1.3	1.1	-1.0	1.0
Reaction time trials correct on left	0.2	0.3	0.7	0.9	-0.8	-0.2	0.2	0.1
Reaction time trials on left	0.2	0.3	0.9	0.9	-0.9	-0.2	0.2	0.1
Reaction time mean	0.2	0.3	0.9	0.1	-0.1	-0.6	0.5	-1.0
Reaction time mean AUC	0.1	0.2	0.5	0.2	-0.2	-0.5	0.1	-0.7
Median of all reaction times	0.1	0.1	0.5	0.1	-0.1	-0.3	0.0	-0.7
Reaction time omissions	0.3	0.4	1.0	1.0	-0.9	-0.1	-0.3	0.3
Reaction time false alarm rate	0.4	0.6	1.0	0.5	-0.6	1.0	-0.9	0.7
Reaction time premature initiation rate	0.6	0.7	1.9	-1.4	1.1	-0.2	-0.6	-0.2
Reaction time premature initiations	0.2	0.3	0.6	-0.8	0.6	-0.2	-0.5	-0.2
Std. dev. reaction times	0.7	0.9	1.8	-0.1	0.2	-1.2	1.2	-1.3
Reaction time trials completed	0.2	0.3	0.9	0.9	-0.9	-0.2	0.2	0.1
Reaction time trials AUC	0.4	0.6	1.5	1.2	-1.1	-0.0	0.2	0.3
Run reversals in cocaine runway, females	0.6	0.6	1.4	-0.1	0.1	-0.6	1.1	-1.2
Run reversals in cocaine runway, males	1.4	1.3	3.4	1.9	-1.5	-0.1	-0.6	0.8
Latency to leave start box in cocaine runway	0.3	0.4	1.0	0.1	-0.1	-0.3	1.0	-0.9
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	0.5	-0.6	0.0	0.8	-0.4
Latency to leave start box in cocaine runway, M	0.1	0.1	0.2	0.1	-0.2	-0.0	0.1	-0.4
Std. dev. time between licks in bursts	1.5	1.9	5.0	-2.2	1.9	-0.4	-0.8	-0.2
Total sessions with >9 infusions	0.8	0.9	1.7	0.8	-1.0	0.9	-1.3	0.6
Short access day 1 total inactive lever presses	1.1	1.2	3.2	-1.8	1.5	-0.2	0.4	-0.6
Short access day 10 total inactive lever presses	1.8	2.0	3.4	-1.8	1.8	-0.9	1.4	-0.8
Short access day 1 total infusions	0.1	0.1	0.2	-0.1	-0.1	0.2	-0.4	-0.2
Short access day 10 total infusions	0.1	0.2	0.5	0.0	-0.2	0.5	-0.7	0.2
Short access total infusions	0.5	0.6	1.4	0.4	-0.7	0.9	-1.2	0.4
Short access day 1 locomotion	0.5	0.5	1.2	1.0	-1.1	0.3	-0.5	0.3
Short access day 10 total locomotion	1.8	2.0	4.6	-2.1	1.8	-0.9	0.0	-1.0
Short access total locomotion	0.5	0.6	1.7	0.1	-0.4	0.7	-1.3	0.7
One hour access (0.3 mA shock)	3.3	3.9	8.7	-2.9	2.5	-1.0	0.1	-1.9
Compulsive drug intake	0.1	0.1	0.1	-0.2	0.2	-0.2	-0.1	-0.4
One hour access (shock baseline)	0.9	1.1	3.0	-1.7	1.3	-0.2	-0.3	-0.7
Social response proportion	2.2	2.4	3.8	-1.7	1.9	-1.3	1.8	-0.7
Social responses	0.5	0.7	1.7	-1.2	1.3	-0.3	0.4	-0.0
Social time	2.7	3.6	4.6	-2.1	2.1	-1.7	1.8	-1.8
Soleus weight	0.2	0.5	1.1	1.0	-0.9	0.4	-0.1	0.7
Bone: stiffness	1.3	2.1	4.0	-1.1	1.2	-1.6	2.0	-1.0
Tibialis anterior weight	0.4	1.4	3.9	2.0	-1.6	0.2	0.8	0.4
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.4	0.3	-0.5	1.2	-0.9	1.0
Time to tail flick, vehicle, after self-admin	0.5	0.5	1.0	-1.0	0.9	-0.0	-0.9	0.4
Time to tail flick, test, before self-admin	0.1	0.1	0.4	0.1	-0.5	0.1	0.1	-0.7
Time to tail flick, test, after self-admin	0.0	0.0	0.1	0.3	-0.4	-0.0	-0.1	-0.1
Delta time to tail flick, vehicle, before/after SA	0.7	0.7	1.4	-0.9	0.9	-1.2	-0.0	-0.8
Delta time to tail flick, test, before/after SA	0.8	0.7	1.0	0.8	-0.6	0.6	-1.0	1.0
Tibia length	3.0	8.3	13.7	-1.8	2.1	-3.4	3.7	-3.0
Ambulatory time before self-admin	0.5	0.5	1.3	-1.1	1.0	0.3	-0.5	-0.0
Ambulatory time after self-admin	8.6	9.4	11.5	-3.3	3.4	-3.0	2.5	-3.0
Bone: tissue strength	4.1	3.9	6.7	-1.6	1.7	-1.9	2.6	-1.9
Total heroin consumption	1.2	1.4	3.3	-1.8	1.7	-0.2	0.6	-0.6
Bone: trabecular number	1.5	2.3	3.7	-1.1	1.2	-1.9	1.7	-1.5
Bone: trabecular spacing	0.1	0.2	0.4	-0.4	0.5	-0.3	-0.7	-0.2
Bone: trabecular thickness	0.3	0.4	0.9	0.9	-0.9	-0.1	0.5	-0.2
Bone: trabecular tissue density	3.0	4.2	6.9	2.6	-2.5	1.6	-1.6	1.7
Water consumed over 24 hours	0.4	0.5	0.7	-0.5	0.5	-0.8	0.8	-0.7
Number of responses in last shaping day	0.7	0.7	2.0	-1.4	1.0	0.3	-0.4	-0.5