Hub : Genes

LOC108349515

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 NAcc mRNA stability LOC108349515 0.08 0.06 2.3e-12 0.06 0.08 0.09 0.08 2.7e-09 4.0e-12 5.6e-13 2.6e-12
2 NAcc gene expression LOC108349515 0.15 0.12 6.6e-14 0.09 0.09 0.09 0.09 2.1e-13 2.4e-13 1.1e-13 1.2e-13
3 BLA mRNA stability LOC108349515 0.1 0.07 1.0e-04 0.06 0.06 0.05 0.06 6.0e-04 3.8e-04 9.4e-04 3.1e-04
4 Brain mRNA stability LOC108349515 0.03 0.02 2.0e-03 0.04 0.03 0.03 0.04 4.3e-05 8.7e-04 3.8e-04 1.5e-04
5 PL mRNA stability LOC108349515 0.07 0.05 2.7e-08 0.07 0.06 0.06 0.06 4.9e-08 4.5e-07 9.3e-07 1.2e-06
6 PL gene expression LOC108349515 0.07 0.07 9.9e-05 0.03 0.04 0.05 0.04 1.1e-04 4.2e-05 8.0e-06 2.9e-05
7 BLA gene expression LOC108349515 0.13 0.09 6.0e-04 0.01 0.04 0.04 0.04 8.2e-02 2.0e-03 2.9e-03 3.1e-03
8 IC gene expression LOC108349515 0.15 0.11 7.1e-03 0.02 0.04 0.08 0.04 3.7e-02 9.0e-03 2.4e-04 8.3e-03
9 pVTA gene expression LOC108349515 0.1 0.07 1.4e-03 0.03 0.02 0.02 0.03 2.8e-03 4.8e-03 1.4e-02 3.5e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9
Bone: apparent density0.00.10.20.10.10.40.20.40.10.10.3-0.2
Area under the delay curve0.40.51.0-0.7-0.9-0.7-1.0-0.6-0.9-0.5-0.1-0.3
BMI with tail0.41.43.3-1.8-1.2-1.5-1.2-1.4-1.0-0.6-0.8-0.1
BMI without tail0.10.40.80.80.60.50.60.10.70.90.40.8
Body weight1.35.58.12.82.92.02.51.82.62.71.42.0
Weight adjusted by age0.20.31.70.1-0.00.70.51.30.20.00.5-0.4
Bone surface2.74.97.12.52.72.42.62.12.42.11.71.2
Bone volume2.03.65.02.22.22.12.11.92.01.71.60.9
Breakpoint value in progressive ratio session0.30.31.30.4-0.0-0.80.1-0.6-0.1-0.5-1.1-0.3
Number of licking bursts0.00.00.2-0.1-0.2-0.3-0.1-0.2-0.1-0.2-0.4-0.1
Context. condit. distance diff. score0.20.20.5-0.5-0.4-0.50.00.0-0.3-0.7-0.6-0.7
Locomotion velocity, session 12.62.86.9-1.7-1.6-0.1-0.91.0-1.8-2.3-1.7-2.6
Locomotion distance, session 11.21.65.01.20.91.71.52.20.6-0.2-0.3-1.1
Locomotion velocity, session 20.91.12.6-0.9-1.1-0.3-0.60.3-1.2-1.5-1.0-1.6
Locomotion distance, session 20.81.23.61.20.91.80.91.90.50.30.5-0.5
Locomotion velocity, session 30.10.10.40.2-0.2-0.2-0.10.0-0.4-0.5-0.1-0.6
Locomotion distance, session 30.20.20.60.40.20.40.50.70.0-0.4-0.3-0.8
Stereotopy head waving bouts, day 30.20.21.3-0.3-0.2-0.50.3-0.50.3-0.0-1.10.2
Stereotopy head waving duration, day 30.10.20.5-0.3-0.2-0.50.2-0.50.30.1-0.70.4
Locomotion velocity, session 70.20.20.50.1-0.10.10.40.5-0.0-0.5-0.5-0.7
Locomotion distance, session 70.30.41.1-0.8-0.7-0.2-0.30.5-0.7-0.8-0.4-1.0
Stereotopy head waving bouts, day 70.60.71.51.11.00.41.20.11.20.7-0.50.7
Stereotopy head waving duration, day 70.50.61.20.90.90.31.10.11.10.7-0.10.7
Locomotion velocity, session 80.50.62.0-0.1-0.3-0.10.20.5-0.5-1.2-1.2-1.4
Locomotion distance, session 80.20.30.90.1-0.10.40.30.9-0.2-0.6-0.4-1.0
Degree of sensitization distance0.00.00.1-0.3-0.1-0.10.10.10.0-0.1-0.2-0.1
Degree of sensitization stereotypy0.30.30.70.80.70.20.7-0.10.80.6-0.20.6
Conditioned locomotion0.20.20.9-0.4-0.1-0.10.50.5-0.1-0.6-0.6-0.9
Cocaine response after cond. corrected1.01.33.5-1.1-0.7-1.2-1.5-1.9-0.80.21.10.8
Cocaine response after cond. not corrected0.50.62.40.20.50.5-0.2-0.30.41.11.61.1
Cocaine response before conditioning4.65.510.12.52.53.22.83.12.31.70.80.6
Saline control response0.50.72.8-0.2-0.0-0.30.60.7-0.3-1.1-0.8-1.7
Bone: connectivity density0.10.10.3-0.6-0.2-0.2-0.3-0.2-0.3-0.10.5-0.2
Bone: cortical apparent density0.81.02.0-1.4-1.00.1-1.10.6-1.3-0.71.1-1.1
Bone: cortical area0.91.42.41.51.41.01.61.01.41.00.30.7
Bone: cortical porosity0.30.30.90.40.2-0.70.4-1.00.3-0.2-1.00.1
Bone: cortical porosity0.60.61.41.21.0-0.21.0-0.71.00.4-0.60.6
Bone: cortical thickness0.40.71.3-0.8-0.9-0.9-0.4-0.5-0.7-1.0-1.1-0.8
Bone: cortical thickness0.20.30.6-0.8-0.50.3-0.40.6-0.5-0.30.5-0.5
Bone: cortical tissue density0.71.01.8-1.3-1.00.1-1.10.6-1.3-0.71.2-1.1
Condit. Reinf. active minus inactive responses0.10.10.50.70.1-0.50.1-0.50.0-0.2-0.2-0.1
Condit. Reinf. active-inactive response ratio0.80.82.2-0.5-0.9-1.5-1.0-1.4-0.8-0.7-0.3-0.2
Condit. Reinf. active responses0.40.51.31.10.90.51.00.30.80.3-0.20.1
Condit. Reinf. inactive responses2.42.95.11.82.02.22.32.11.81.0-0.10.3
Incentive salience index mean0.20.21.11.00.50.30.40.20.30.20.20.0
Condit. Reinf. lever presses0.40.51.10.90.61.00.41.00.40.60.80.2
Condit. Reinf. active minus inactive responses3.24.17.12.72.42.12.62.22.31.60.20.9
Condit. Reinf. active-inactive response ratio5.05.88.52.92.72.62.62.22.62.41.51.7
Condit. Reinf. active responses2.63.67.02.52.21.92.72.22.10.9-0.80.3
Condit. Reinf. inactive responses0.50.73.70.80.5-0.00.90.40.5-0.6-1.9-0.6
Condit. Reinf. lever presses2.02.76.22.52.10.91.80.32.11.6-0.11.6
Condit. Reinf. lever reinforcers received3.24.58.62.82.42.22.92.52.31.1-0.50.4
Conditioned reinforcement - actives0.50.93.8-1.3-0.30.6-0.60.1-0.20.91.90.8
Conditioned reinforcement - inactives1.01.43.70.30.51.90.51.80.51.21.70.5
Conditioned locomotion0.20.31.3-0.50.20.4-0.10.00.10.71.10.6
Patch foraging indifference point 0 sec0.71.32.7-1.7-1.5-0.8-0.9-0.3-1.3-1.3-0.7-1.3
Patch foraging indifference point AUC0.40.60.9-1.0-1.0-0.8-0.8-0.9-0.7-0.6-0.2-0.3
Delay disc. indifference point, 0s delay0.80.92.2-1.5-1.4-0.3-0.50.6-0.8-1.1-0.4-1.1
Delay disc. indifference point, 16s delay0.50.52.30.90.5-0.6-0.3-1.50.10.5-0.20.8
Delay disc. indifference point, 2s delay1.61.83.8-1.9-1.8-0.9-1.9-0.4-1.8-1.00.1-0.8
Delay disc. indifference point, 24s delay0.30.31.40.4-0.1-0.7-0.5-1.2-0.3-0.0-0.30.3
Delay disc. indifference point, 4s delay0.10.10.30.20.10.3-0.30.1-0.10.40.60.3
Delay disc. indifference point, 8s delay0.20.20.5-0.7-0.7-0.3-0.6-0.2-0.6-0.4-0.0-0.3
Indifference point function ln k2.54.49.02.32.22.62.73.02.11.30.30.2
Indifference point function log k2.54.49.02.32.22.62.73.02.11.30.30.2
Patch foraging total patch changes 0 sec0.61.22.3-1.5-1.4-0.8-0.9-0.3-1.2-1.3-0.7-1.3
Patch foraging total patch changes 12 sec0.30.41.4-1.2-0.7-0.4-0.6-0.7-0.4-0.20.5-0.1
Patch foraging total patch changes 18 sec0.50.71.1-1.0-0.9-1.0-1.0-0.7-1.0-0.8-0.2-0.6
Patch foraging total patch changes 24 sec0.30.51.21.10.60.30.2-0.40.50.81.00.8
Patch foraging total patch changes 6 sec0.71.12.1-1.5-1.3-1.1-1.2-1.1-1.1-0.9-0.2-0.5
Patch foraging time to switch 0 sec1.22.49.40.20.1-1.6-1.6-3.1-0.31.01.22.1
Patch foraging water rate 0 sec0.30.62.3-0.3-0.10.80.81.50.1-0.6-0.6-1.1
Patch foraging water rate 12 sec0.81.66.50.80.61.61.52.60.7-0.2-0.3-1.0
Patch foraging water rate 18 sec0.50.72.70.10.31.01.11.60.5-0.3-0.6-0.8
Patch foraging water rate 24 sec0.40.52.10.20.61.01.01.40.5-0.0-0.1-0.5
Patch foraging water rate 6 sec5.17.516.04.03.43.02.92.72.72.21.21.2
Seeking ratio, delayed vs. immediate footshock0.70.81.7-1.2-0.8-0.10.40.9-0.3-1.1-0.9-1.3
Distance traveled before self-admin1.01.36.5-0.3-0.31.01.12.50.2-0.8-0.5-1.5
Distance traveled after self-admin1.41.75.4-0.9-1.1-0.90.50.4-0.5-1.8-2.3-1.8
Extensor digitorum longus weight0.31.42.21.31.40.71.10.51.41.50.81.3
Bone: elastic displacement0.70.83.6-0.3-0.7-0.80.2-0.3-0.2-1.1-1.9-0.9
Bone: elastic work0.20.20.90.30.10.50.51.00.30.1-0.5-0.2
Bone: endosteal estimation2.75.87.52.72.72.52.32.12.52.72.11.9
Bone: endosteal perimeter1.73.75.32.32.21.92.11.72.12.01.31.3
Epididymis fat weight0.41.53.92.01.10.00.3-0.71.01.50.71.9
Delta time in closed arm before/after self-admin1.01.04.4-2.1-1.20.0-1.0-0.3-0.8-0.30.9-0.1
Delta time in open arm before/after self-admin1.51.54.31.21.41.12.11.61.50.4-0.4-0.1
Diff in mean of infusions in LGA sessions0.40.40.9-1.0-0.8-0.0-0.60.6-0.8-0.7-0.2-0.8
Delay discount exponential model param0.30.30.80.50.70.50.90.50.70.30.10.2
Extinction: sum of active levers before priming0.30.31.10.6-0.2-0.40.30.2-0.0-0.7-1.1-0.6
Active lever presses in extinction session 60.80.81.61.11.3-0.10.3-1.00.81.10.31.2
Bone: final force1.32.13.61.21.41.91.01.81.11.61.80.9
Bone: final moment1.52.44.41.31.52.11.12.11.21.61.80.8
Food consumed during 24 hour testing period1.11.52.71.21.31.61.31.51.21.21.00.6
Glucose1.93.04.6-2.1-2.0-1.7-1.7-1.1-1.9-1.9-1.3-1.4
Heart weight1.72.63.71.81.91.71.61.01.81.81.51.3
Delay discount hyperbolic model param0.40.51.20.70.90.61.10.50.90.50.00.3
Intermittent access intake day 1-15 change0.40.71.21.11.10.90.81.00.70.90.50.5
Intermittent access intake escalation0.81.63.71.91.71.11.11.11.11.30.60.9
Intermittent access intake escalation 20.20.30.70.80.30.10.40.80.1-0.3-0.7-0.5
Intermitt. access day 1 inactive lever presses0.62.35.02.21.81.61.31.01.41.71.21.3
Intermitt. access day 15 inactive lever presses1.63.45.30.71.62.31.91.32.02.22.31.6
Intermitt. access escalation Index0.70.94.1-2.0-1.0-1.0-0.8-0.6-0.9-0.5-0.2-0.2
Intermittent access day 1 total infusions0.30.61.8-0.10.60.80.10.40.31.11.30.9
Intermittent access day 15 total infusions0.91.32.41.21.51.00.40.70.71.61.31.3
Intermittent access terminal intake (last 3 days)0.81.01.81.31.40.90.10.80.51.31.11.0
Intermittent access total infusions1.11.33.40.51.11.30.21.00.51.51.81.1
Intermittent access day 1 locomotion0.70.92.50.40.81.20.11.00.31.31.60.9
Intermittent access day 15 total locomotion0.30.53.00.50.61.00.21.7-0.00.50.4-0.1
Intermittent access total locomotion1.51.93.61.21.41.70.71.90.81.61.60.9
Intermittent access standard deviation0.20.30.8-0.3-0.2-0.9-0.8-0.3-0.8-0.6-0.6-0.4
Left kidney weight4.721.731.25.55.65.05.34.65.14.42.62.6
Right kidney weight5.223.834.85.95.85.35.44.05.54.93.03.3
Cocaine induced anxiety1.01.53.61.41.41.11.91.01.60.90.00.4
Post-drug Anxiety2.02.15.62.42.10.81.80.31.81.1-0.20.9
Baseline Anxiety0.40.41.10.1-0.3-0.9-1.0-1.0-0.8-0.4-0.40.0
Tail length3.011.820.94.64.03.73.83.23.63.12.11.8
Length with tail3.314.224.44.94.63.63.93.04.13.92.42.7
Length without tail2.16.911.92.73.52.02.41.22.93.22.32.7
Times rat made contact with spout0.10.10.2-0.4-0.1-0.2-0.1-0.50.10.20.20.5
Lifetime Intake0.81.03.7-0.20.61.1-0.10.80.31.31.91.0
Liver weight, left0.91.62.11.21.41.41.41.11.51.30.90.9
Liver weight, right0.00.00.1-0.0-0.00.10.1-0.10.20.2-0.30.4
Locomotor activity0.10.10.3-0.1-0.1-0.3-0.3-0.5-0.10.1-0.20.4
Locomotor testing distance0.20.41.00.20.50.20.2-0.40.61.00.91.0
Locomotor testing rearing0.51.02.10.61.01.01.00.61.11.21.50.8
Locomotion in novel chamber1.41.83.2-1.8-1.1-1.6-1.4-1.1-1.5-1.2-1.1-0.9
Locomotion in novel chamber post-restriction0.91.43.5-1.9-1.5-0.9-1.6-1.1-1.3-0.40.6-0.0
Fecal boli incidents, locomotor time 10.10.10.50.30.20.60.10.70.10.30.40.0
Change in fecal boli incidents, locomotor task3.63.56.7-2.6-2.3-1.9-2.2-1.4-2.1-1.7-0.7-1.1
Time >=10cm from walls, locomotor time 10.00.00.1-0.20.1-0.1-0.2-0.3-0.10.10.40.2
Bouts of movement, locomotor time 10.70.82.3-1.1-0.80.30.31.5-0.3-1.0-0.4-1.3
Total resting periods, locomotor time 10.60.61.2-1.0-1.0-0.1-0.20.8-0.6-1.0-0.5-1.1
Rest time, locomotor task time 10.91.11.91.31.11.40.61.20.81.11.30.6
Distance moved, locomotor task time 10.81.22.8-0.8-1.1-1.4-0.5-1.2-0.7-1.2-1.7-0.7
Vertical activity count, locomotor time 11.94.67.5-2.7-2.7-2.2-1.5-1.1-1.9-2.5-2.3-1.9
Time >=10cm from walls, locomotor time 20.30.51.2-0.7-0.6-0.9-0.9-1.1-0.7-0.5-0.2-0.1
Bouts of movement, locomotor time 20.00.00.10.10.20.20.00.10.10.10.30.1
Total resting periods, locomotor time 20.00.00.1-0.2-0.10.2-0.20.2-0.10.00.3-0.1
Rest time, locomotor task time 20.20.30.8-0.9-0.70.0-0.30.5-0.5-0.50.1-0.6
Distance moved, locomotor task time 20.10.10.6-0.0-0.1-0.50.1-0.4-0.0-0.4-0.8-0.2
Vertical activity count, locomotor time 20.20.30.6-0.7-0.8-0.6-0.4-0.3-0.5-0.6-0.7-0.5
Light reinforcement 10.71.63.8-2.0-1.4-0.4-0.50.6-1.2-1.6-0.3-1.9
Light reinforcement 21.82.84.9-2.2-2.0-1.8-1.6-0.9-1.9-1.8-0.7-1.6
Bone: marrow area2.76.07.72.72.82.52.32.12.62.82.12.0
Bone: maximum diameter1.52.74.22.02.01.31.80.92.01.81.01.5
Bone: maximum force2.44.25.32.12.22.31.82.12.02.32.11.5
Bone: maximum moment2.54.46.02.12.22.41.92.32.02.22.01.4
Mean time between licks in bursts0.61.52.3-1.2-1.4-1.0-1.0-0.4-1.3-1.5-1.5-1.3
Mean num. licks in bursts0.20.30.90.10.30.40.10.10.40.81.00.7
Cd content in liver1.31.52.60.81.41.61.51.61.31.00.90.3
Co content in liver0.70.82.3-1.3-0.60.6-0.21.5-0.6-0.50.7-1.1
Cu content in liver0.60.71.80.11.01.00.80.90.80.91.30.4
Fe content in liver0.20.20.40.10.50.50.50.50.50.50.60.2
K content in liver0.00.00.1-0.10.30.10.4-0.00.2-0.00.2-0.2
Mg content in liver0.10.10.4-0.10.4-0.20.1-0.60.30.40.60.4
Mn content in liver0.50.51.31.20.9-0.11.0-0.40.90.5-0.00.5
Na content in liver1.92.03.5-1.5-1.4-1.9-1.0-1.7-1.2-1.5-1.2-1.0
Rb content in liver3.44.06.72.52.62.02.31.32.31.91.01.3
Se content in liver0.91.03.6-1.0-0.6-1.8-0.7-1.9-0.4-0.4-0.60.2
Sr content in liver9.68.318.9-4.3-3.9-2.6-2.7-1.3-3.0-3.0-1.5-2.2
Zn content in liver0.40.51.5-0.60.2-0.4-0.7-1.2-0.20.50.90.8
Bone: minimum diameter3.25.89.73.12.92.62.82.32.62.11.11.2
Time in familiar zone, hab. session 11.21.15.3-0.00.31.50.72.30.30.41.2-0.5
Time in novel zone, hab. session 11.31.33.2-0.6-0.8-1.6-0.7-1.8-0.7-1.1-1.8-0.3
Total zone transitions, hab. session 10.71.03.40.1-0.10.90.31.7-0.6-1.1-0.7-1.8
Total locomotion distance, hab. session 10.50.72.6-0.4-0.50.4-0.11.1-0.7-1.1-0.7-1.6
Locomotion velocity, hab. session 10.40.51.8-0.2-0.30.4-0.10.9-0.6-0.9-0.6-1.3
Time in familiar zone, hab. session 23.53.75.41.92.11.91.51.21.92.32.31.8
Time in novel zone, hab. session 22.02.03.6-1.3-1.5-1.6-1.0-1.1-1.3-1.6-1.9-1.1
Total zone transitions, hab. session 21.51.94.11.81.41.81.82.01.10.3-0.2-0.6
Total locomotion distance, hab. session 20.30.41.4-0.1-0.30.2-0.00.6-0.5-0.9-0.7-1.2
Locomotion velocity, hab. session 20.40.61.9-0.3-0.50.0-0.10.6-0.7-1.1-1.0-1.4
Novel to familiar place preference ratio0.10.10.30.40.30.10.4-0.00.50.4-0.00.4
Novelty place preference0.20.20.40.60.50.30.60.20.60.50.10.4
Time in novel zone, NPP test0.20.30.50.60.60.40.60.30.70.60.30.5
Total zone transitions, NPP test0.20.30.90.40.30.80.20.9-0.2-0.3-0.1-0.7
Total locomotion distance, NPP test0.30.41.21.10.80.90.70.70.60.30.00.1
Locomotion velocity, NPP test0.30.41.01.00.70.90.80.80.40.1-0.2-0.3
Intraocular pressure0.10.20.40.6-0.3-0.3-0.3-0.0-0.4-0.5-0.3-0.5
Delta distance traveled before/after self-admin1.11.22.7-0.6-0.9-1.6-0.7-1.7-0.7-1.0-1.5-0.4
Delta ambulatory time before/after self-admin0.91.11.8-1.2-1.2-1.3-0.9-1.4-0.9-1.0-1.0-0.5
Parametrial fat weight1.33.27.3-2.7-2.0-2.0-1.9-2.0-1.7-1.2-0.9-0.3
Pavlov. Cond. lever latency0.10.20.3-0.5-0.5-0.5-0.2-0.2-0.4-0.5-0.3-0.5
Pavlov. Cond. magazine entry latency0.30.41.4-0.5-0.5-0.7-0.9-1.2-0.5-0.2-0.40.3
Pavlov. Cond. change in total contacts0.30.30.6-0.7-0.6-0.5-0.7-0.5-0.7-0.4-0.2-0.3
Pavlov. Cond. index score0.20.20.6-0.5-0.5-0.4-0.8-0.6-0.6-0.3-0.3-0.0
Pavlov. Cond. latency score0.10.20.5-0.4-0.4-0.3-0.7-0.6-0.5-0.1-0.20.1
Pavlov. Cond. lever contacts0.40.50.90.80.80.50.4-0.00.70.90.40.9
Pavlov. Cond. magazine entry number0.10.10.50.20.20.40.60.70.30.00.1-0.3
Pavlov. Cond. intertrial magazine entries1.01.23.2-0.9-0.8-0.30.20.6-0.6-1.5-1.7-1.8
Pavlov. Cond. lever-magazine prob. diff.0.20.20.5-0.5-0.4-0.5-0.7-0.7-0.5-0.3-0.30.0
Pavlov. Cond. response bias0.20.20.70.40.40.1-0.2-0.50.20.60.40.8
Pavlov. Cond. lever latency0.40.53.40.00.20.8-0.20.6-0.00.51.80.2
Pavlov. Cond. magazine entry latency0.40.51.2-0.6-0.7-1.1-0.4-1.1-0.3-0.4-1.00.1
Pavlov. Cond. change in total contacts0.40.62.60.70.4-0.01.20.50.7-0.1-1.6-0.4
Pavlov. Cond. index score0.20.31.60.30.1-0.40.5-0.30.4-0.0-1.30.1
Pavlov. Cond. latency score0.30.42.0-0.1-0.3-0.80.1-0.70.1-0.3-1.4-0.0
Pavlov. Cond. lever contacts0.30.42.70.30.1-0.50.5-0.30.4-0.2-1.6-0.0
Pavlov. Cond. magazine entry number0.30.40.80.80.80.90.50.80.40.40.70.1
Pavlov. Cond. intertrial magazine entries2.53.76.12.52.42.32.12.11.91.51.10.8
Pavlov. Cond. lever-magazine prob. diff.0.20.31.8-0.0-0.2-0.50.3-0.40.2-0.2-1.3-0.1
Pavlov. Cond. response bias0.40.51.50.90.60.21.00.20.90.3-1.20.3
Time in closed arm before self-admin0.81.02.11.51.30.91.20.91.10.80.30.5
Time in closed arm after self-admin0.30.31.1-0.10.30.5-0.1-0.20.20.71.00.8
Time in open arm before self-admin2.72.97.7-2.8-2.3-1.4-2.1-1.5-1.8-1.2-0.0-0.7
Time in open arm after self-admin0.40.40.9-0.8-0.6-0.60.10.0-0.3-0.8-1.0-0.9
Bone: periosteal estimation2.14.46.02.52.42.12.31.92.32.21.41.5
Bone: periosteal perimeter1.62.74.11.91.91.62.01.61.91.50.80.9
Bone: post-yield work4.05.89.12.63.02.22.41.52.62.72.42.0
Progressive ratio test 1 active lever presses0.30.41.4-0.9-0.40.80.01.2-0.20.10.8-0.3
Progressive ratio test 1 breakpoint0.30.41.4-0.8-0.40.8-0.01.2-0.20.10.8-0.3
Progressive ratio test 1 inactive lever presses1.31.84.60.10.72.10.81.90.81.32.00.7
Progressive ratio test 2 active lever presses0.70.81.70.61.10.80.20.30.51.31.21.1
Progressive ratio test 2 breakpoint0.81.02.00.71.20.90.30.40.71.41.21.2
Progressive ratio test 2 inactive lever presses1.52.54.90.71.52.21.31.91.31.81.81.0
Incentive Sensitization - Responses2.33.26.82.42.61.41.40.61.72.11.11.8
Incentive Sensitization - Breakpoint2.02.65.82.22.41.11.20.41.62.00.91.8
Sum of active levers in priming session hrs 5-60.40.31.20.5-0.1-0.30.60.30.1-0.6-1.1-0.7
Progressive ratio0.10.20.4-0.1-0.20.20.60.50.2-0.6-0.6-0.6
Food seeking constrained by brief footshock4.15.010.2-3.0-2.9-0.1-0.22.1-1.4-2.9-1.6-3.2
Seeking ratio, punishment vs. effort0.10.21.2-0.1-0.10.50.21.1-0.1-0.20.1-0.5
Retroperitoneal fat weight2.39.821.1-3.3-3.3-4.2-4.0-4.6-3.0-1.6-0.90.2
Reaction time number correct0.20.41.1-1.0-0.5-0.6-0.3-0.2-0.5-0.6-1.0-0.4
Reaction time mean minus median0.00.00.0-0.1-0.10.10.00.1-0.00.10.0-0.1
Reaction time mean minus median AUC0.00.00.2-0.4-0.0-0.0-0.1-0.20.00.20.30.2
Reaction time num false alarms0.10.10.6-0.8-0.2-0.2-0.1-0.0-0.2-0.1-0.2-0.2
Reaction time num false alarms AUC0.71.03.5-1.9-1.1-0.7-0.7-0.1-1.0-1.0-0.7-1.1
Reaction time trials correct on left0.20.41.1-1.0-0.5-0.6-0.3-0.2-0.5-0.6-1.0-0.4
Reaction time trials on left0.20.41.2-1.1-0.5-0.6-0.4-0.2-0.5-0.7-1.0-0.4
Reaction time mean0.81.22.01.41.21.11.00.61.11.31.20.9
Reaction time mean AUC0.50.71.41.00.80.70.60.10.81.11.20.9
Median of all reaction times0.91.32.41.61.21.10.90.51.11.31.31.0
Reaction time omissions0.40.61.5-1.2-0.8-0.4-0.40.3-0.8-0.9-0.3-1.1
Reaction time false alarm rate0.30.41.3-1.1-0.8-0.4-0.40.1-0.7-0.6-0.3-0.8
Reaction time premature initiation rate0.20.20.70.80.40.30.1-0.00.20.50.90.4
Reaction time premature initiations0.00.10.10.30.2-0.1-0.2-0.30.00.20.30.3
Std. dev. reaction times0.40.81.10.91.00.90.80.50.91.10.90.7
Reaction time trials completed0.20.41.2-1.1-0.5-0.6-0.4-0.2-0.5-0.7-1.0-0.4
Reaction time trials AUC0.10.20.7-0.7-0.3-0.5-0.3-0.2-0.3-0.4-0.8-0.2
Run reversals in cocaine runway, females0.70.71.50.90.90.80.70.10.91.01.20.9
Run reversals in cocaine runway, males0.10.10.6-0.2-0.4-0.0-0.5-0.0-0.40.20.80.2
Latency to leave start box in cocaine runway0.40.40.80.90.80.80.50.80.60.60.60.3
Latency to leave start box in cocaine runway, F0.10.10.50.10.00.3-0.00.30.00.20.70.1
Latency to leave start box in cocaine runway, M1.41.32.61.61.61.11.11.11.11.00.40.7
Std. dev. time between licks in bursts1.41.95.1-1.0-1.2-0.5-0.30.5-1.1-1.9-2.2-2.1
Total sessions with >9 infusions0.60.71.9-1.4-0.31.00.21.20.00.51.30.1
Short access day 1 total inactive lever presses1.01.32.41.41.41.00.50.30.81.51.41.3
Short access day 10 total inactive lever presses0.20.42.01.40.80.40.10.40.30.50.30.4
Short access day 1 total infusions0.40.51.7-1.3-0.90.1-0.80.1-0.7-0.00.8-0.1
Short access day 10 total infusions0.40.62.3-1.5-0.9-0.1-0.90.0-0.8-0.20.7-0.2
Short access total infusions0.91.14.2-2.0-1.3-0.2-1.3-0.2-1.1-0.21.1-0.1
Short access day 1 locomotion0.50.63.1-0.8-0.20.7-0.30.3-0.00.91.80.7
Short access day 10 total locomotion0.20.52.5-0.4-0.40.70.11.6-0.3-0.30.2-0.7
Short access total locomotion1.01.24.2-2.0-1.50.2-0.71.2-1.1-0.70.4-1.0
One hour access (0.3 mA shock)2.93.45.01.32.22.21.71.91.72.11.81.4
Compulsive drug intake2.12.55.02.22.11.42.01.41.71.3-0.10.8
One hour access (shock baseline)0.60.93.9-0.40.40.8-0.30.10.21.22.01.1
Social response proportion1.82.05.32.31.81.21.00.41.31.51.11.3
Social responses3.03.97.62.72.42.22.01.62.01.81.31.1
Social time1.82.46.51.21.42.32.02.51.40.50.2-0.3
Soleus weight0.10.20.50.30.50.10.40.20.40.50.70.3
Bone: stiffness2.03.24.41.52.02.11.71.91.81.91.91.2
Tibialis anterior weight0.41.44.0-0.9-0.9-1.9-1.3-2.0-0.6-0.0-0.50.8
Time to tail flick, vehicle, before self-admin0.20.21.1-0.1-0.10.50.61.10.2-0.2-0.0-0.5
Time to tail flick, vehicle, after self-admin1.11.57.42.71.50.60.40.20.71.10.51.0
Time to tail flick, test, before self-admin1.31.42.2-1.1-1.4-0.7-1.10.6-1.5-1.4-0.8-1.5
Time to tail flick, test, after self-admin0.20.21.1-1.1-0.5-0.30.0-0.70.0-0.10.30.1
Delta time to tail flick, vehicle, before/after SA0.80.83.11.70.9-0.3-0.9-0.8-0.30.70.31.0
Delta time to tail flick, test, before/after SA0.80.81.80.10.80.71.2-0.41.31.10.91.1
Tibia length3.710.315.53.93.73.53.52.63.63.21.92.2
Ambulatory time before self-admin0.71.14.90.10.11.01.42.20.6-0.5-0.4-1.1
Ambulatory time after self-admin1.11.33.2-1.1-0.7-0.21.11.00.2-1.4-1.8-1.6
Bone: tissue strength0.50.51.1-1.0-0.70.2-0.40.9-0.7-0.70.0-1.0
Total heroin consumption0.20.20.60.5-0.0-0.30.50.20.2-0.4-0.8-0.4
Bone: trabecular number0.20.40.8-0.9-0.8-0.4-0.7-0.3-0.8-0.6-0.1-0.6
Bone: trabecular spacing0.10.10.30.50.30.00.0-0.20.20.3-0.20.5
Bone: trabecular thickness0.00.10.5-0.0-0.00.0-0.00.1-0.00.10.7-0.0
Bone: trabecular tissue density0.20.31.7-0.3-0.2-0.8-0.4-1.3-0.1-0.00.20.4
Water consumed over 24 hours0.30.41.70.20.41.10.61.30.40.30.5-0.2
Number of responses in last shaping day0.60.62.6-1.0-0.70.3-0.7-0.3-0.30.51.60.5