Hub : Genes

LOC108349062

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC108349062 0.56 0.16 8.2e-05 0.01 0.02 0.01 0.01 1.3e-02 4.7e-03 1.7e-02 2.0e-02
2 IL isoform ratio XR_001835682.3 0.14 0.13 7.7e-03 0.08 0.08 0.1 0.1 5.8e-03 5.1e-03 1.9e-03 2.3e-03
3 OFC gene expression LOC108349062 0.3 0.22 3.9e-05 0.16 0.19 0.19 0.19 1.1e-04 3.1e-05 2.7e-05 3.1e-05
4 BLA gene expression LOC108349062 0.26 0.18 7.2e-10 0.14 0.14 0.14 0.14 1.2e-07 9.7e-08 8.9e-08 7.3e-08
5 NAcc gene expression LOC108349062 0.12 0.12 1.0e-10 0.07 0.06 0.07 0.07 3.4e-11 9.0e-10 6.2e-11 3.9e-11
6 pVTA gene expression LOC108349062 0.1 0.11 4.9e-04 0.02 0.01 0.01 0.02 1.1e-02 2.0e-02 2.9e-02 1.8e-02
7 PL gene expression LOC108349062 0.42 0.19 0.0e+00 0.43 0.44 0.44 0.44 3.4e-51 7.8e-52 2.2e-52 2.9e-52
8 IC intron excision ratio chr1_87842541_87843063 0.11 0.11 5.2e-03 0.03 0.03 0.03 0.03 1.6e-02 2.4e-02 1.6e-02 2.5e-02
9 IL gene expression LOC108349062 0.57 0.23 8.4e-11 0.35 0.36 0.35 0.36 3.3e-09 1.3e-09 3.5e-09 1.9e-09
10 PL mRNA stability LOC108349062 0.07 0.05 1.7e-08 0.07 0.08 0.07 0.07 1.8e-08 1.1e-08 1.1e-07 1.7e-08
11 Brain gene expression LOC108349062 0.25 0.15 0.0e+00 0.18 0.18 0.17 0.18 1.1e-16 1.7e-16 2.3e-15 1.4e-16
12 IC gene expression LOC108349062 0.39 0.19 3.5e-08 0.15 0.15 0.14 0.15 8.2e-07 9.4e-07 1.5e-06 1.1e-06
13 PL isoform ratio XR_001835682.3 0.02 0.02 1.9e-03 0.02 0.02 0.03 0.02 1.4e-03 2.1e-03 8.4e-04 2.1e-03
14 Brain mRNA stability LOC108349062 0.29 0.19 5.2e-03 0.01 0.01 0.01 0.01 3.7e-02 2.2e-02 1.4e-02 8.1e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Bone: apparent density0.00.00.30.5-0.20.20.10.20.2-0.00.10.0-0.00.2-0.00.40.1
Area under the delay curve1.41.63.1-0.31.2-1.0-1.1-1.3-1.2-1.3-1.2-1.3-1.3-1.3-1.41.5-1.8
BMI with tail0.82.75.82.4-2.02.02.11.71.91.51.61.51.51.21.3-0.7-0.1
BMI without tail1.23.711.13.3-2.32.42.41.92.11.71.91.71.71.31.3-0.5-0.6
Body weight1.66.914.83.9-3.23.23.22.62.92.52.82.52.42.12.1-1.50.2
Weight adjusted by age0.10.10.30.4-0.10.30.30.40.30.20.40.10.1-0.0-0.00.4-0.5
Bone surface0.30.51.01.0-0.90.90.90.80.80.60.70.70.60.80.6-0.60.2
Bone volume0.20.40.90.9-0.70.70.70.70.70.50.60.60.50.70.5-0.20.4
Breakpoint value in progressive ratio session2.22.74.0-1.82.0-2.0-2.0-1.8-1.8-1.5-1.2-1.7-1.7-1.7-1.41.4-0.6
Number of licking bursts2.43.94.61.7-2.21.91.92.02.02.12.12.02.11.82.1-2.11.6
Context. condit. distance diff. score0.10.10.3-0.2-0.10.10.10.10.00.30.20.30.30.20.4-0.40.6
Locomotion velocity, session 10.10.10.5-0.60.5-0.5-0.5-0.3-0.2-0.2-0.2-0.3-0.3-0.3-0.10.70.1
Locomotion distance, session 10.10.11.1-1.10.2-0.2-0.2-0.10.00.0-0.10.00.00.50.00.10.6
Locomotion velocity, session 21.51.72.91.7-1.51.51.51.41.41.31.31.31.31.11.2-1.30.4
Locomotion distance, session 20.20.30.60.2-0.60.60.60.50.60.50.50.60.50.80.4-0.40.3
Locomotion velocity, session 30.30.30.80.9-0.70.70.70.50.60.50.50.50.50.40.4-0.5-0.1
Locomotion distance, session 30.80.92.0-0.50.9-0.7-0.7-1.0-1.0-1.0-1.0-0.9-0.9-1.1-1.10.5-1.4
Stereotopy head waving bouts, day 31.01.11.41.2-1.21.01.01.01.01.11.11.11.10.91.2-1.10.9
Stereotopy head waving duration, day 30.91.12.10.5-1.00.80.81.01.01.11.01.11.11.11.2-1.21.4
Locomotion velocity, session 70.30.30.7-0.80.6-0.5-0.5-0.7-0.6-0.5-0.5-0.5-0.5-0.5-0.50.5-0.2
Locomotion distance, session 70.00.00.2-0.0-0.20.30.3-0.10.00.10.10.10.1-0.0-0.0-0.2-0.5
Stereotopy head waving bouts, day 71.01.12.50.8-1.00.80.81.01.01.11.11.11.11.01.3-0.81.6
Stereotopy head waving duration, day 70.81.01.60.8-1.00.80.81.10.91.01.01.01.00.91.1-0.91.3
Locomotion velocity, session 80.00.00.1-0.20.1-0.0-0.0-0.2-0.2-0.1-0.2-0.1-0.0-0.2-0.00.0-0.3
Locomotion distance, session 80.00.00.0-0.20.00.10.1-0.1-0.1-0.1-0.00.00.00.0-0.00.1-0.1
Degree of sensitization distance0.50.50.60.4-0.80.70.70.60.70.80.80.70.70.70.8-0.60.7
Degree of sensitization stereotypy1.11.22.30.8-1.10.90.91.21.11.11.11.11.11.11.2-0.81.5
Conditioned locomotion0.10.10.2-0.40.3-0.3-0.3-0.1-0.2-0.2-0.2-0.2-0.2-0.2-0.30.3-0.2
Cocaine response after cond. corrected0.50.61.20.2-0.70.60.60.50.60.80.80.80.80.70.8-1.11.1
Cocaine response after cond. not corrected1.21.42.10.7-1.21.11.11.01.11.31.31.21.21.21.3-1.41.4
Cocaine response before conditioning1.61.92.41.1-1.51.41.41.51.51.41.51.41.41.31.4-1.11.0
Saline control response2.02.63.01.3-1.71.51.51.71.61.71.51.71.71.71.7-1.71.7
Bone: connectivity density0.00.10.20.5-0.10.10.10.10.0-0.2-0.0-0.2-0.2-0.0-0.30.5-0.4
Bone: cortical apparent density0.10.10.80.00.3-0.3-0.3-0.0-0.0-0.3-0.2-0.3-0.3-0.5-0.30.9-0.1
Bone: cortical area1.52.43.11.3-1.81.71.71.51.41.51.51.61.61.61.5-1.81.0
Bone: cortical porosity0.20.20.40.10.3-0.3-0.3-0.5-0.5-0.4-0.5-0.4-0.3-0.5-0.3-0.3-0.6
Bone: cortical porosity0.10.10.50.7-0.20.20.2-0.1-0.1-0.0-0.10.00.1-0.10.1-0.6-0.4
Bone: cortical thickness0.50.91.20.6-1.11.01.00.90.90.90.91.01.01.10.9-1.00.8
Bone: cortical thickness1.31.52.01.0-1.31.31.21.31.31.21.21.31.31.41.3-1.01.2
Bone: cortical tissue density0.10.21.0-0.10.4-0.4-0.4-0.1-0.1-0.4-0.3-0.4-0.4-0.6-0.41.0-0.2
Condit. Reinf. active minus inactive responses0.60.61.81.3-1.00.91.00.80.90.70.90.70.70.50.7-0.40.1
Condit. Reinf. active-inactive response ratio0.50.51.91.4-0.90.80.80.80.80.60.80.60.60.50.6-0.10.2
Condit. Reinf. active responses0.30.40.80.9-0.80.80.80.60.70.50.70.60.50.50.5-0.10.1
Condit. Reinf. inactive responses0.10.21.0-1.00.4-0.3-0.3-0.5-0.3-0.3-0.4-0.3-0.30.0-0.40.20.1
Incentive salience index mean0.50.62.41.5-0.90.91.00.80.80.60.80.60.60.40.6-0.2-0.2
Condit. Reinf. lever presses0.20.31.91.4-0.50.60.60.40.50.30.40.20.2-0.00.20.0-0.7
Condit. Reinf. active minus inactive responses0.10.10.3-0.6-0.20.20.20.20.20.30.30.30.20.30.3-0.20.5
Condit. Reinf. active-inactive response ratio0.30.31.1-0.5-0.40.30.30.40.40.60.50.60.50.70.6-0.71.0
Condit. Reinf. active responses0.10.10.6-0.80.3-0.3-0.3-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.30.3-0.2
Condit. Reinf. inactive responses0.50.70.9-0.70.9-0.9-0.8-0.8-0.8-0.9-0.9-0.9-0.9-0.9-0.80.7-0.8
Condit. Reinf. lever presses0.10.20.3-0.1-0.50.50.50.30.30.30.30.40.40.40.3-0.50.2
Condit. Reinf. lever reinforcers received0.10.20.6-0.80.4-0.4-0.4-0.3-0.4-0.4-0.4-0.4-0.4-0.3-0.30.2-0.2
Conditioned reinforcement - actives1.52.64.52.1-1.91.91.91.82.01.41.21.61.61.51.3-0.80.4
Conditioned reinforcement - inactives1.11.67.32.7-1.51.61.61.21.11.01.01.01.00.70.5-0.1-1.0
Conditioned locomotion1.82.43.90.6-1.51.41.41.52.01.71.51.71.61.81.6-0.71.9
Patch foraging indifference point 0 sec0.30.62.1-0.3-0.60.50.40.30.30.70.70.80.81.00.8-1.31.5
Patch foraging indifference point AUC3.75.47.82.8-2.62.52.52.72.72.42.42.22.22.12.1-1.51.0
Delay disc. indifference point, 0s delay0.91.03.10.30.8-0.6-0.6-0.9-0.9-1.0-0.9-1.1-1.1-1.2-1.11.3-1.8
Delay disc. indifference point, 16s delay1.01.13.30.20.9-0.6-0.7-0.9-0.9-1.1-1.0-1.0-1.0-1.1-1.21.0-1.8
Delay disc. indifference point, 2s delay2.83.17.1-0.11.5-1.3-1.4-1.5-1.4-1.8-1.7-1.8-1.8-1.9-1.92.4-2.7
Delay disc. indifference point, 24s delay0.10.10.5-0.7-0.0-0.0-0.1-0.2-0.1-0.1-0.10.10.10.30.1-0.20.6
Delay disc. indifference point, 4s delay0.00.00.10.1-0.10.10.10.10.10.10.30.00.00.1-0.10.3-0.3
Delay disc. indifference point, 8s delay1.51.72.3-1.11.4-1.3-1.4-1.5-1.4-1.3-1.2-1.4-1.4-1.3-1.31.5-1.0
Indifference point function ln k1.52.75.5-2.31.8-1.9-1.9-2.1-2.2-1.6-1.8-1.4-1.4-1.0-1.20.10.3
Indifference point function log k1.52.75.5-2.31.8-1.9-1.9-2.1-2.2-1.6-1.8-1.4-1.4-1.0-1.20.10.3
Patch foraging total patch changes 0 sec0.51.03.6-0.2-0.80.60.50.40.50.90.81.01.01.41.0-1.61.9
Patch foraging total patch changes 12 sec2.02.65.22.3-1.91.81.81.81.81.61.61.51.51.31.5-1.20.5
Patch foraging total patch changes 18 sec2.03.04.31.1-1.81.61.51.71.91.82.01.71.72.01.8-1.32.1
Patch foraging total patch changes 24 sec0.61.13.11.8-1.11.11.01.41.40.91.00.80.80.90.8-0.10.4
Patch foraging total patch changes 6 sec2.33.55.01.2-2.11.81.81.71.71.91.81.91.92.21.9-2.22.0
Patch foraging time to switch 0 sec2.14.37.2-0.82.0-1.8-1.8-2.0-1.9-2.1-2.0-2.2-2.2-2.5-2.12.6-2.7
Patch foraging water rate 0 sec2.55.27.81.3-2.32.12.02.32.12.32.22.42.42.62.2-2.82.5
Patch foraging water rate 12 sec0.10.20.70.1-0.40.40.40.30.20.30.30.50.40.60.2-0.80.6
Patch foraging water rate 18 sec0.10.10.40.5-0.40.40.30.20.10.30.00.40.40.60.2-0.60.4
Patch foraging water rate 24 sec0.50.72.6-0.6-0.60.40.40.60.60.80.70.80.81.00.8-1.11.6
Patch foraging water rate 6 sec0.60.81.20.7-0.90.90.91.01.00.90.81.00.91.10.8-0.70.9
Seeking ratio, delayed vs. immediate footshock1.92.33.3-1.41.8-1.7-1.7-1.6-1.5-1.5-1.4-1.5-1.6-1.6-1.61.3-1.0
Distance traveled before self-admin0.00.00.1-0.2-0.30.20.30.00.30.1-0.10.30.20.4-0.10.10.1
Distance traveled after self-admin0.30.40.8-0.90.6-0.6-0.6-0.5-0.5-0.6-0.9-0.5-0.5-0.4-0.70.5-0.3
Extensor digitorum longus weight2.07.913.03.6-3.23.02.92.82.82.82.92.82.82.72.8-2.11.8
Bone: elastic displacement0.70.81.50.50.9-0.9-0.9-0.9-0.9-0.9-0.7-1.0-1.0-1.1-0.71.2-0.8
Bone: elastic work0.20.21.61.3-0.50.50.50.20.20.30.40.20.20.20.3-0.3-0.2
Bone: endosteal estimation0.10.11.00.70.00.20.2-0.2-0.2-0.2-0.2-0.2-0.2-0.3-0.2-0.2-1.0
Bone: endosteal perimeter0.00.10.70.3-0.20.30.3-0.1-0.1-0.1-0.10.00.0-0.1-0.0-0.4-0.8
Epididymis fat weight0.20.62.10.30.6-0.5-0.5-0.6-0.6-0.8-0.7-0.8-0.7-1.1-0.80.9-1.4
Delta time in closed arm before/after self-admin0.70.62.9-1.70.8-0.9-0.8-1.1-0.8-0.6-0.6-0.5-0.5-0.2-0.50.60.3
Delta time in open arm before/after self-admin0.20.21.41.2-0.40.40.40.60.50.10.30.00.0-0.10.10.4-0.6
Diff in mean of infusions in LGA sessions1.41.72.9-1.61.6-1.7-1.7-1.3-1.0-1.1-0.9-1.3-1.3-1.3-1.11.6-0.2
Delay discount exponential model param1.01.12.10.4-1.00.91.01.11.01.11.01.11.11.11.2-1.31.5
Extinction: sum of active levers before priming0.00.00.10.10.2-0.1-0.1-0.3-0.3-0.10.1-0.2-0.2-0.30.20.00.0
Active lever presses in extinction session 60.30.31.31.1-0.60.60.60.10.30.40.40.40.40.20.5-0.5-0.1
Bone: final force0.50.81.21.0-1.11.11.10.90.80.80.90.80.80.80.9-0.80.2
Bone: final moment0.71.11.71.3-1.31.31.31.01.01.01.01.01.01.01.0-1.00.2
Food consumed during 24 hour testing period4.86.78.3-2.32.9-2.7-2.7-2.5-2.6-2.7-2.7-2.7-2.7-2.6-2.62.5-2.0
Glucose0.40.72.5-1.61.0-1.0-1.0-0.7-0.6-0.6-0.7-0.7-0.7-0.9-0.60.8-0.2
Heart weight1.82.83.70.7-1.71.51.51.61.71.81.61.81.81.81.8-1.81.9
Delay discount hyperbolic model param0.91.02.20.3-0.90.80.91.00.91.00.91.01.01.01.2-1.31.5
Intermittent access intake day 1-15 change0.10.20.30.3-0.50.50.40.40.50.40.40.40.40.40.3-0.50.2
Intermittent access intake escalation0.10.30.50.6-0.70.70.60.60.60.50.50.50.50.50.4-0.60.1
Intermittent access intake escalation 20.10.21.1-1.00.2-0.3-0.3-0.4-0.2-0.0-0.0-0.0-0.00.1-0.1-0.60.5
Intermitt. access day 1 inactive lever presses0.10.21.01.0-0.40.50.50.30.10.30.30.20.20.00.10.4-0.8
Intermitt. access day 15 inactive lever presses0.10.21.00.5-0.10.20.20.00.30.40.70.10.10.0-0.41.0-0.7
Intermitt. access escalation Index0.20.30.5-0.50.7-0.6-0.6-0.5-0.6-0.5-0.5-0.5-0.5-0.6-0.40.6-0.1
Intermittent access day 1 total infusions2.13.37.42.7-2.12.12.12.12.01.71.61.71.71.51.5-1.20.3
Intermittent access day 15 total infusions1.01.62.61.6-1.41.41.41.51.61.21.31.21.21.11.0-0.10.5
Intermittent access terminal intake (last 3 days)1.21.62.21.1-1.41.31.31.51.41.31.41.31.31.31.2-0.71.0
Intermittent access total infusions2.73.24.31.8-2.01.91.92.12.01.91.91.81.81.71.8-0.91.4
Intermittent access day 1 locomotion0.50.71.81.3-0.91.01.00.91.10.80.80.70.70.60.60.4-0.1
Intermittent access day 15 total locomotion0.20.31.00.8-0.70.70.70.61.00.50.50.50.50.50.30.1-0.1
Intermittent access total locomotion1.82.23.41.5-1.71.61.61.71.81.51.51.51.51.41.4-0.60.8
Intermittent access standard deviation0.10.20.4-0.60.5-0.5-0.5-0.5-0.3-0.4-0.2-0.5-0.5-0.4-0.40.5-0.2
Left kidney weight5.525.633.04.6-5.75.45.45.25.25.15.35.25.15.14.8-4.83.5
Right kidney weight5.022.729.34.2-5.45.15.14.74.84.95.04.94.94.94.7-4.33.7
Cocaine induced anxiety0.40.54.50.90.2-0.1-0.1-0.30.2-0.2-0.1-0.4-0.4-0.6-0.42.1-1.1
Post-drug Anxiety0.10.10.60.30.1-0.1-0.2-0.30.0-0.1-0.2-0.1-0.1-0.3-0.00.7-0.2
Baseline Anxiety0.91.05.7-2.40.7-1.0-1.0-0.9-0.8-0.3-0.6-0.2-0.20.00.1-1.01.8
Tail length0.62.47.02.7-1.91.92.01.31.41.41.61.41.41.31.1-0.8-0.2
Length with tail0.52.35.62.4-1.81.81.81.41.51.41.61.41.31.31.2-0.80.1
Length without tail0.41.21.81.0-1.21.21.21.31.31.11.41.11.01.11.0-0.70.9
Times rat made contact with spout0.20.20.9-1.00.4-0.4-0.4-0.4-0.4-0.2-0.3-0.2-0.2-0.0-0.1-0.10.6
Lifetime Intake2.93.65.02.2-2.12.12.12.22.11.92.01.81.81.71.8-0.91.2
Liver weight, left2.43.95.82.4-2.32.12.11.92.12.01.92.02.01.91.9-1.81.0
Liver weight, right1.83.26.82.6-2.22.12.11.91.91.61.81.71.61.51.5-1.00.5
Locomotor activity1.92.94.30.7-1.81.61.61.61.61.91.61.81.81.81.8-2.11.8
Locomotor testing distance1.12.02.51.1-1.61.51.61.41.51.51.31.51.51.51.2-1.50.8
Locomotor testing rearing4.48.911.32.7-3.43.23.23.13.13.12.93.03.03.02.9-2.82.0
Locomotion in novel chamber0.81.04.6-2.11.0-1.2-1.2-0.9-1.2-0.7-0.8-0.6-0.6-0.4-0.4-0.90.8
Locomotion in novel chamber post-restriction0.91.52.3-1.11.4-1.1-1.1-1.3-1.5-1.3-1.4-1.2-1.2-1.0-1.40.2-1.3
Fecal boli incidents, locomotor time 10.10.20.90.8-0.40.40.40.40.20.30.20.30.30.10.3-0.9-0.1
Change in fecal boli incidents, locomotor task0.70.72.0-0.20.7-0.6-0.6-0.8-0.8-0.8-0.7-0.8-0.8-0.8-0.91.4-1.2
Time >=10cm from walls, locomotor time 10.00.00.00.2-0.10.10.0-0.00.0-0.1-0.1-0.0-0.1-0.1-0.20.2-0.1
Bouts of movement, locomotor time 12.42.73.8-1.61.8-1.7-1.6-1.7-1.6-1.6-1.5-1.7-1.7-1.7-1.72.0-1.1
Total resting periods, locomotor time 13.03.35.4-1.62.0-1.8-1.8-1.8-1.8-1.8-1.7-1.9-1.9-1.9-1.92.3-1.4
Rest time, locomotor task time 10.20.20.3-0.40.5-0.4-0.4-0.5-0.5-0.4-0.3-0.5-0.5-0.5-0.60.5-0.6
Distance moved, locomotor task time 10.40.60.80.7-0.80.70.70.80.80.70.80.80.80.80.9-0.70.6
Vertical activity count, locomotor time 10.10.11.21.1-0.40.40.40.20.30.10.10.10.1-0.10.20.1-0.5
Time >=10cm from walls, locomotor time 20.10.10.90.30.1-0.0-0.1-0.3-0.2-0.3-0.4-0.2-0.2-0.3-0.30.1-1.0
Bouts of movement, locomotor time 25.28.311.2-3.33.3-3.1-3.1-2.9-2.8-2.8-2.6-2.8-2.8-2.7-2.83.1-1.6
Total resting periods, locomotor time 24.47.712.1-3.53.2-3.1-3.1-2.8-2.7-2.7-2.4-2.7-2.7-2.5-2.72.9-1.3
Rest time, locomotor task time 20.20.21.1-1.00.5-0.5-0.5-0.3-0.3-0.20.0-0.3-0.3-0.2-0.30.50.6
Distance moved, locomotor task time 20.91.11.81.4-1.11.21.21.01.01.00.91.01.01.01.0-1.10.2
Vertical activity count, locomotor time 20.20.31.81.3-0.20.40.4-0.10.1-0.1-0.2-0.1-0.1-0.3-0.10.3-1.2
Light reinforcement 10.10.20.40.7-0.50.40.40.50.50.30.30.40.30.40.3-0.30.2
Light reinforcement 20.50.83.82.0-0.91.11.11.00.80.50.60.50.40.30.3-0.1-0.9
Bone: marrow area0.10.10.90.8-0.10.20.2-0.1-0.2-0.1-0.1-0.1-0.1-0.2-0.1-0.3-0.9
Bone: maximum diameter2.24.25.31.9-2.32.22.22.02.02.12.12.12.12.02.1-2.31.2
Bone: maximum force0.20.40.70.7-0.80.80.80.50.50.60.60.60.60.60.6-0.8-0.0
Bone: maximum moment0.30.61.00.9-0.91.01.00.60.60.70.70.70.70.70.6-0.9-0.1
Mean time between licks in bursts0.00.00.20.20.1-0.1-0.1-0.3-0.2-0.2-0.1-0.2-0.2-0.0-0.20.4-0.1
Mean num. licks in bursts3.04.65.9-2.42.4-2.2-2.2-2.3-2.3-2.3-2.3-2.1-2.2-1.8-2.12.0-1.1
Cd content in liver0.30.41.9-1.40.7-0.7-0.7-0.2-0.2-0.3-0.2-0.4-0.4-0.2-0.30.90.7
Co content in liver1.21.42.7-1.21.4-1.4-1.4-1.0-1.0-1.1-1.0-1.2-1.2-1.3-1.11.7-0.6
Cu content in liver0.50.51.31.2-0.80.70.60.80.80.80.80.70.70.60.7-0.40.6
Fe content in liver4.55.57.31.0-2.42.12.12.42.52.62.52.42.52.52.6-2.12.7
K content in liver0.60.63.82.0-0.90.90.80.40.40.40.40.50.50.40.5-0.8-0.5
Mg content in liver0.90.92.61.6-1.21.21.20.80.80.80.80.90.90.70.7-1.0-0.3
Mn content in liver1.21.42.91.7-1.41.41.41.11.11.11.11.11.10.91.1-1.10.3
Na content in liver0.20.20.70.4-0.30.20.10.20.20.40.20.40.40.50.5-0.60.8
Rb content in liver0.10.10.20.3-0.30.30.30.10.10.20.10.30.20.40.2-0.30.2
Se content in liver4.24.96.42.3-2.52.32.32.22.22.22.22.22.32.22.3-2.11.5
Sr content in liver0.00.00.10.3-0.20.20.20.20.20.20.20.20.20.00.2-0.2-0.0
Zn content in liver1.21.34.92.2-1.31.31.21.01.01.01.01.01.00.91.0-0.80.3
Bone: minimum diameter0.20.41.11.1-0.80.80.80.50.50.50.50.60.60.70.5-0.70.1
Time in familiar zone, hab. session 10.10.10.5-0.1-0.30.20.20.10.20.30.20.40.40.20.4-0.70.4
Time in novel zone, hab. session 10.80.81.21.1-1.00.90.91.11.00.91.00.80.80.90.9-0.60.6
Total zone transitions, hab. session 10.10.20.6-0.3-0.30.30.30.30.40.30.20.40.40.70.4-0.20.8
Total locomotion distance, hab. session 10.30.50.6-0.50.7-0.7-0.7-0.7-0.6-0.8-0.8-0.7-0.7-0.4-0.80.8-0.6
Locomotion velocity, hab. session 11.11.62.0-0.91.3-1.2-1.2-1.3-1.2-1.4-1.4-1.3-1.3-1.0-1.41.4-1.1
Time in familiar zone, hab. session 20.40.40.70.9-0.70.60.60.60.60.70.70.60.60.70.7-0.30.5
Time in novel zone, hab. session 20.20.31.2-1.10.5-0.6-0.6-0.4-0.5-0.4-0.5-0.3-0.3-0.3-0.2-0.20.2
Total zone transitions, hab. session 20.40.60.80.4-0.80.70.60.70.80.80.70.80.80.80.9-0.90.8
Total locomotion distance, hab. session 20.40.60.7-0.40.9-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.8-0.70.7-0.8
Locomotion velocity, hab. session 20.30.40.6-0.20.6-0.6-0.6-0.6-0.6-0.7-0.7-0.6-0.6-0.6-0.70.5-0.8
Novel to familiar place preference ratio0.40.40.8-0.2-0.60.60.60.60.60.60.50.70.60.90.5-0.80.7
Novelty place preference0.30.30.7-0.3-0.50.60.60.50.50.60.40.60.60.80.4-0.80.6
Time in novel zone, NPP test0.40.40.9-0.3-0.60.60.60.60.60.60.50.70.70.90.5-0.90.8
Total zone transitions, NPP test0.10.10.4-0.2-0.30.30.30.10.20.30.20.40.40.30.3-0.60.3
Total locomotion distance, NPP test0.10.10.4-0.6-0.10.10.00.00.10.20.10.30.30.30.3-0.50.6
Locomotion velocity, NPP test0.10.10.3-0.5-0.10.10.1-0.00.10.20.10.20.20.30.2-0.50.4
Intraocular pressure0.20.32.1-1.40.5-0.6-0.6-0.3-0.4-0.2-0.2-0.2-0.2-0.2-0.1-0.40.7
Delta distance traveled before/after self-admin1.31.43.80.31.1-0.9-0.9-0.7-1.1-1.2-1.2-1.3-1.3-1.4-1.21.2-1.9
Delta ambulatory time before/after self-admin0.30.41.20.30.5-0.4-0.4-0.3-0.6-0.7-0.7-0.6-0.6-0.7-0.70.6-1.1
Parametrial fat weight0.10.20.80.9-0.60.60.50.50.40.40.40.40.40.40.4-0.4-0.0
Pavlov. Cond. lever latency0.60.71.5-1.20.9-0.9-0.9-1.0-1.0-0.8-0.9-0.8-0.8-0.7-0.90.4-0.4
Pavlov. Cond. magazine entry latency0.20.21.21.1-0.50.50.50.40.60.30.40.30.30.30.4-0.2-0.1
Pavlov. Cond. change in total contacts0.50.61.0-0.40.8-0.7-0.7-0.7-0.6-0.8-0.7-0.8-0.8-0.8-0.81.0-0.9
Pavlov. Cond. index score0.30.41.21.1-0.70.70.70.70.80.60.60.60.60.50.7-0.30.3
Pavlov. Cond. latency score0.10.20.80.9-0.40.40.40.50.50.30.40.30.30.10.40.1-0.1
Pavlov. Cond. lever contacts0.40.51.51.2-0.80.70.70.90.80.70.80.70.70.50.7-0.20.3
Pavlov. Cond. magazine entry number0.10.11.0-1.00.3-0.3-0.3-0.3-0.5-0.2-0.2-0.2-0.2-0.0-0.3-0.00.2
Pavlov. Cond. intertrial magazine entries0.10.10.5-0.6-0.10.10.00.20.20.30.30.20.20.30.20.10.7
Pavlov. Cond. lever-magazine prob. diff.0.30.41.01.0-0.70.70.70.70.80.60.60.60.60.50.7-0.30.3
Pavlov. Cond. response bias1.01.32.91.7-1.31.21.21.11.31.01.11.11.11.01.1-0.70.5
Pavlov. Cond. lever latency0.00.00.10.10.2-0.2-0.2-0.1-0.1-0.1-0.1-0.1-0.1-0.1-0.10.20.0
Pavlov. Cond. magazine entry latency0.00.00.1-0.3-0.10.10.20.10.20.10.20.10.00.1-0.00.30.1
Pavlov. Cond. change in total contacts0.30.41.2-1.10.6-0.7-0.7-0.7-0.7-0.6-0.7-0.6-0.6-0.3-0.60.20.0
Pavlov. Cond. index score0.00.00.1-0.40.1-0.1-0.0-0.2-0.2-0.2-0.2-0.2-0.2-0.1-0.30.2-0.2
Pavlov. Cond. latency score0.10.10.1-0.40.2-0.2-0.1-0.3-0.3-0.3-0.3-0.3-0.3-0.2-0.40.3-0.3
Pavlov. Cond. lever contacts0.10.10.20.2-0.50.40.50.30.30.30.30.30.30.30.2-0.4-0.0
Pavlov. Cond. magazine entry number0.30.40.60.8-0.60.50.50.60.50.60.60.60.70.60.7-0.80.6
Pavlov. Cond. intertrial magazine entries0.00.00.1-0.20.1-0.1-0.20.0-0.0-0.0-0.10.10.10.20.1-0.20.4
Pavlov. Cond. lever-magazine prob. diff.0.00.00.1-0.3-0.10.10.1-0.00.00.00.00.0-0.00.1-0.10.10.0
Pavlov. Cond. response bias0.00.00.0-0.2-0.10.00.1-0.1-0.0-0.1-0.0-0.1-0.1-0.1-0.10.0-0.2
Time in closed arm before self-admin0.81.01.70.1-0.90.90.81.31.31.10.91.00.91.10.9-0.61.2
Time in closed arm after self-admin1.51.74.7-2.21.4-1.5-1.5-1.2-1.0-1.1-1.2-1.0-1.1-0.8-1.21.6-0.1
Time in open arm before self-admin0.80.92.40.10.9-0.8-0.7-1.1-1.3-1.0-0.9-0.9-0.9-1.1-0.90.2-1.6
Time in open arm after self-admin0.20.31.81.4-0.20.30.30.0-0.2-0.10.2-0.2-0.2-0.5-0.0-0.2-1.1
Bone: periosteal estimation0.30.71.41.2-1.01.01.00.70.60.70.70.80.80.70.7-1.2-0.1
Bone: periosteal perimeter0.40.71.31.1-1.01.11.10.60.60.60.70.70.70.60.6-1.1-0.3
Bone: post-yield work0.60.92.2-0.60.9-0.6-0.6-0.9-0.9-1.1-1.0-1.0-1.0-0.8-1.21.0-1.5
Progressive ratio test 1 active lever presses3.34.17.42.7-2.42.32.32.32.01.91.91.91.91.81.7-1.70.7
Progressive ratio test 1 breakpoint3.34.08.42.9-2.42.42.42.32.01.81.81.91.91.71.8-1.50.5
Progressive ratio test 1 inactive lever presses1.62.44.82.2-1.91.91.81.61.71.51.51.51.51.41.1-0.5-0.3
Progressive ratio test 2 active lever presses3.13.67.32.7-2.22.12.12.32.11.81.81.81.81.61.6-1.30.7
Progressive ratio test 2 breakpoint3.53.97.62.8-2.32.22.22.42.22.01.91.91.91.71.7-1.30.8
Progressive ratio test 2 inactive lever presses0.81.47.22.7-1.21.41.41.21.00.70.90.70.70.40.20.2-1.3
Incentive Sensitization - Responses1.52.14.12.0-1.71.51.51.91.61.41.41.41.41.21.3-1.20.6
Incentive Sensitization - Breakpoint1.51.93.81.9-1.61.41.41.81.61.31.31.31.31.11.2-1.00.6
Sum of active levers in priming session hrs 5-60.50.41.3-1.10.8-0.9-0.9-0.8-0.7-0.5-0.2-0.5-0.5-0.5-0.20.10.6
Progressive ratio0.91.53.0-0.61.4-1.3-1.3-0.9-1.0-1.2-1.2-1.2-1.2-1.4-1.11.7-1.0
Food seeking constrained by brief footshock5.36.47.7-2.32.8-2.6-2.6-2.5-2.5-2.6-2.6-2.6-2.6-2.4-2.72.5-2.1
Seeking ratio, punishment vs. effort0.60.81.3-1.00.9-0.7-0.7-1.1-1.0-1.0-0.9-0.9-1.0-0.7-1.10.6-1.0
Retroperitoneal fat weight0.00.20.50.7-0.50.50.50.40.40.50.50.40.40.00.4-0.3-0.3
Reaction time number correct3.26.211.50.9-2.52.12.02.22.22.62.52.62.62.92.6-3.03.4
Reaction time mean minus median0.61.59.2-3.01.2-1.3-1.3-1.3-1.0-0.6-0.7-0.6-0.6-0.3-0.30.41.3
Reaction time mean minus median AUC0.30.85.4-2.30.4-0.6-0.6-0.5-0.20.10.00.10.10.40.4-0.31.9
Reaction time num false alarms5.27.311.73.4-3.12.92.92.92.92.72.72.62.62.52.6-2.01.5
Reaction time num false alarms AUC4.36.712.63.5-3.02.82.82.72.62.52.52.42.42.32.5-2.01.3
Reaction time trials correct on left3.26.211.50.9-2.52.12.02.22.22.62.52.62.62.92.6-3.03.4
Reaction time trials on left3.36.211.20.9-2.52.12.02.22.22.62.52.62.62.92.6-2.93.3
Reaction time mean1.62.66.3-2.51.8-1.7-1.7-2.0-1.6-1.5-1.5-1.5-1.5-1.5-1.31.4-0.4
Reaction time mean AUC1.32.04.6-2.11.6-1.5-1.5-1.8-1.5-1.3-1.3-1.3-1.3-1.2-1.11.1-0.2
Median of all reaction times1.72.43.3-1.71.6-1.5-1.4-1.8-1.6-1.5-1.5-1.6-1.6-1.6-1.41.5-1.1
Reaction time omissions0.00.00.10.1-0.20.30.3-0.10.00.00.30.00.0-0.20.10.4-0.4
Reaction time false alarm rate0.60.83.92.0-1.01.11.10.90.90.60.70.60.60.30.6-0.1-0.6
Reaction time premature initiation rate0.40.61.50.10.6-0.4-0.4-0.7-0.7-0.9-1.1-0.7-0.7-0.9-0.80.8-1.2
Reaction time premature initiations0.20.30.70.5-0.60.50.50.30.30.40.10.60.60.70.5-0.90.7
Std. dev. reaction times0.61.25.8-2.41.2-1.2-1.2-1.4-1.0-0.7-0.7-0.8-0.8-0.6-0.50.50.7
Reaction time trials completed3.36.211.20.9-2.52.12.02.22.22.62.52.62.62.92.6-2.93.3
Reaction time trials AUC4.07.612.91.2-2.82.42.32.42.52.92.82.92.93.22.9-3.23.6
Run reversals in cocaine runway, females0.30.30.6-0.40.5-0.5-0.5-0.4-0.4-0.6-0.6-0.5-0.5-0.5-0.70.6-0.8
Run reversals in cocaine runway, males0.40.40.50.4-0.60.60.60.60.60.70.70.70.70.50.7-0.70.6
Latency to leave start box in cocaine runway0.40.52.6-1.60.4-0.4-0.3-0.4-0.5-0.3-0.60.00.00.40.0-1.01.2
Latency to leave start box in cocaine runway, F0.60.73.0-1.2-0.30.20.30.10.10.3-0.20.70.70.90.7-1.61.7
Latency to leave start box in cocaine runway, M0.20.20.3-0.50.5-0.4-0.4-0.4-0.4-0.4-0.3-0.4-0.4-0.2-0.50.3-0.1
Std. dev. time between licks in bursts0.10.10.60.8-0.40.40.40.20.20.10.20.20.10.30.1-0.3-0.0
Total sessions with >9 infusions3.94.76.01.9-2.42.22.32.42.32.22.22.22.22.22.1-1.81.9
Short access day 1 total inactive lever presses2.02.611.93.4-1.82.02.01.71.61.11.41.11.10.70.90.4-1.0
Short access day 10 total inactive lever presses0.51.11.5-0.71.2-1.1-1.1-1.0-1.2-1.0-0.9-1.2-1.2-1.2-0.91.2-1.1
Short access day 1 total infusions2.22.93.91.9-1.91.81.82.01.81.61.71.71.71.61.7-1.31.3
Short access day 10 total infusions4.15.26.72.5-2.62.52.52.62.32.22.22.32.22.22.2-1.91.6
Short access total infusions2.83.65.92.4-2.22.12.12.21.91.81.81.81.81.71.7-1.41.1
Short access day 1 locomotion4.15.17.52.7-2.52.52.52.72.62.32.52.22.12.02.0-0.61.1
Short access day 10 total locomotion0.00.10.5-0.70.1-0.2-0.2-0.2-0.0-0.10.10.0-0.00.10.1-0.10.6
Short access total locomotion0.91.11.81.1-1.21.21.21.31.21.01.11.01.01.01.0-0.30.7
One hour access (0.3 mA shock)0.10.10.20.4-0.40.40.40.30.20.30.20.20.20.20.10.1-0.1
Compulsive drug intake0.30.31.6-1.0-0.10.10.10.3-0.30.30.30.40.30.60.4-1.20.9
One hour access (shock baseline)1.11.73.01.7-1.51.51.51.41.71.41.41.31.21.11.10.10.7
Social response proportion0.70.82.40.0-0.80.60.60.70.81.00.91.00.91.21.0-0.71.6
Social responses0.70.91.50.8-1.01.01.00.90.81.01.01.01.00.90.9-1.20.7
Social time3.14.35.9-1.22.1-1.9-1.9-2.2-2.4-2.4-2.3-2.1-2.1-2.0-2.21.5-2.2
Soleus weight0.10.40.50.7-0.70.70.70.60.60.60.60.60.60.70.6-0.50.4
Bone: stiffness0.81.21.70.8-1.31.31.31.11.11.11.01.11.11.21.0-1.20.5
Tibialis anterior weight3.511.715.23.9-3.83.73.73.53.53.53.43.43.43.33.3-3.02.1
Time to tail flick, vehicle, before self-admin2.72.84.31.2-1.71.51.41.91.71.71.41.81.71.71.8-2.11.9
Time to tail flick, vehicle, after self-admin0.20.32.0-1.40.3-0.5-0.5-0.7-0.6-0.2-0.2-0.0-0.00.1-0.1-0.20.9
Time to tail flick, test, before self-admin0.40.41.8-0.30.6-0.5-0.6-0.6-0.3-0.6-0.4-0.6-0.6-0.8-0.11.4-0.1
Time to tail flick, test, after self-admin0.30.30.90.80.1-0.1-0.1-0.0-0.1-0.5-0.6-0.3-0.3-0.5-0.50.9-1.0
Delta time to tail flick, vehicle, before/after SA0.40.41.5-1.20.6-0.6-0.5-1.2-1.0-0.5-0.3-0.4-0.4-0.3-0.50.2-0.0
Delta time to tail flick, test, before/after SA0.80.81.70.9-1.00.90.91.10.80.80.60.90.91.00.5-1.30.3
Tibia length0.30.81.70.5-1.11.11.31.11.20.80.90.80.80.60.6-0.1-0.3
Ambulatory time before self-admin0.00.00.2-0.40.0-0.1-0.1-0.1-0.1-0.2-0.3-0.1-0.1-0.0-0.20.10.1
Ambulatory time after self-admin0.60.81.5-1.10.9-1.0-1.0-0.7-0.8-0.9-1.2-0.8-0.8-0.7-0.90.6-0.3
Bone: tissue strength0.80.81.1-0.80.9-0.9-0.8-0.9-0.9-1.0-0.9-0.9-0.9-0.9-1.01.0-0.9
Total heroin consumption0.10.10.40.6-0.20.20.20.2-0.00.00.2-0.0-0.0-0.10.1-0.6-0.3
Bone: trabecular number0.00.00.30.20.1-0.1-0.10.10.0-0.2-0.0-0.2-0.2-0.1-0.20.6-0.1
Bone: trabecular spacing0.00.00.20.1-0.0-0.0-0.1-0.1-0.00.10.00.20.20.10.2-0.50.3
Bone: trabecular thickness1.41.82.31.1-1.51.41.41.51.51.41.41.41.31.41.3-0.91.2
Bone: trabecular tissue density0.20.40.5-0.1-0.60.50.60.60.60.60.50.70.70.60.7-0.70.7
Water consumed over 24 hours0.20.30.9-1.00.6-0.7-0.7-0.5-0.6-0.5-0.5-0.5-0.5-0.3-0.40.30.3
Number of responses in last shaping day2.93.27.10.6-1.71.51.51.71.72.02.11.81.81.92.1-1.02.7