LOC108348449

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	OFC	gene expression	LOC108348449	0.34	0.19	3.5e-04	0.01	0.05	0.04	0.06	1.6e-01	2.3e-02	3.2e-02	1.2e-02
2	PL	gene expression	LOC108348449	0.17	0.08	4.1e-14	0.12	0.13	0.12	0.13	1.4e-12	1.2e-13	3.9e-13	1.1e-13
3	LHb	gene expression	LOC108348449	0.29	0.17	6.9e-05	0.13	0.14	0.11	0.11	4.9e-04	4.3e-04	1.7e-03	1.6e-03
4	Liver	alternative TSS	XR_005498947.2	0.02	0.02	2.4e-03	0.01	0.01	0.01	0.01	7.6e-03	2.6e-02	7.7e-03	2.7e-02
5	Adipose	gene expression	LOC108348449	0.1	0.06	9.2e-11	0.05	0.08	0.07	0.07	1.3e-06	7.8e-09	2.6e-08	2.9e-08
6	Liver	gene expression	LOC108348449	0.08	0.04	1.6e-12	0.07	0.09	0.08	0.08	2.5e-08	2.3e-10	2.7e-09	1.2e-09
7	NAcc	gene expression	LOC108348449	0.27	0.1	0.0e+00	0.21	0.2	0.21	0.2	1.3e-30	1.1e-29	1.1e-30	2.8e-30
8	Brain	gene expression	LOC108348449	0.27	0.14	8.7e-15	0.17	0.15	0.17	0.17	1.5e-15	3.8e-14	3.0e-15	1.1e-15
9	pVTA	gene expression	LOC108348449	0.15	0.08	7.4e-06	0.05	0.04	0.03	0.05	8.7e-05	4.5e-04	3.7e-03	1.1e-04
10	IC	gene expression	LOC108348449	0.38	0.14	8.9e-07	0.15	0.17	0.18	0.14	8.7e-07	1.6e-07	7.3e-08	1.4e-06
11	BLA	gene expression	LOC108348449	0.38	0.16	4.6e-06	0.09	0.09	0.1	0.08	2.2e-05	2.2e-05	5.5e-06	4.4e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7	8	9	10	11
Bone: apparent density	0.2	0.3	0.7	-0.4	-0.4	-0.5	0.9	-0.4	-0.5	0.7	-0.6	0.5	0.2	0.6
Area under the delay curve	0.8	1.3	2.1	1.5	1.2	0.9	-1.3	0.9	0.9	-1.2	1.2	-1.2	-0.8	-1.2
BMI with tail	0.6	2.2	3.4	-0.0	1.5	1.3	-1.7	1.5	1.6	-1.3	1.5	-1.6	-1.8	-1.7
BMI without tail	0.1	0.6	2.1	-1.4	0.1	0.2	-0.9	0.2	0.5	-0.3	0.6	-0.7	-1.1	-1.3
Body weight	0.7	3.1	14.3	-3.8	-2.0	-1.9	0.9	-1.8	-1.4	1.5	-1.3	1.1	0.5	0.1
Weight adjusted by age	0.2	0.7	1.5	-1.2	-0.6	-1.1	1.1	-0.9	-1.0	0.7	-0.6	0.6	0.2	0.1
Bone surface	3.4	6.6	8.2	-2.7	-2.3	-2.6	2.7	-2.5	-2.5	2.9	-2.7	2.6	2.2	2.3
Bone volume	2.8	5.5	6.9	-2.3	-2.1	-2.4	2.5	-2.3	-2.3	2.6	-2.5	2.4	2.2	2.3
Breakpoint value in progressive ratio session	1.2	2.2	3.6	1.9	0.8	1.6	-1.7	1.4	1.4	-1.5	1.5	-1.6	-1.1	-1.4
Number of licking bursts	0.0	0.1	0.3	-0.6	0.4	0.1	-0.1	0.1	0.2	-0.1	0.2	-0.3	-0.1	-0.3
Context. condit. distance diff. score	0.1	0.1	0.4	-0.5	-0.3	-0.2	0.3	-0.0	-0.1	0.1	-0.0	0.0	-0.6	-0.4
Locomotion velocity, session 1	0.3	0.3	0.7	-0.0	-0.4	-0.7	0.4	-0.7	-0.9	0.4	-0.5	0.7	0.5	0.4
Locomotion distance, session 1	2.3	2.9	5.8	-1.3	-1.6	-2.1	2.4	-2.0	-2.1	1.3	-1.5	1.7	1.3	0.9
Locomotion velocity, session 2	0.1	0.2	0.7	-0.9	-0.3	-0.5	0.3	-0.4	-0.4	0.3	-0.3	0.4	-0.2	0.1
Locomotion distance, session 2	1.9	2.7	4.0	-2.0	-1.8	-1.9	1.7	-1.8	-1.7	1.5	-1.6	1.6	1.2	1.2
Locomotion velocity, session 3	0.1	0.1	0.3	-0.6	-0.2	-0.2	0.6	-0.2	-0.1	0.4	-0.4	0.5	0.1	0.3
Locomotion distance, session 3	1.0	1.2	2.4	-0.9	-0.8	-1.1	1.6	-0.9	-1.1	1.3	-1.2	1.3	0.3	1.1
Stereotopy head waving bouts, day 3	0.4	0.4	1.0	0.3	0.6	0.6	-0.7	0.5	0.6	-0.9	0.8	-0.6	-0.2	-1.0
Stereotopy head waving duration, day 3	0.4	0.5	1.1	0.5	0.4	0.7	-0.7	0.5	0.6	-1.1	0.9	-0.7	-0.2	-1.1
Locomotion velocity, session 7	0.4	0.4	1.6	0.2	-0.7	-0.4	1.3	-0.5	-0.6	0.3	-0.4	0.5	0.7	0.6
Locomotion distance, session 7	0.1	0.1	0.3	-0.0	-0.3	-0.3	0.5	-0.3	-0.3	0.3	-0.2	0.2	0.2	-0.0
Stereotopy head waving bouts, day 7	0.4	0.4	1.1	-1.1	-0.8	-0.5	0.4	-0.5	-0.5	0.6	-0.6	0.8	0.5	0.6
Stereotopy head waving duration, day 7	0.2	0.2	0.7	-0.8	-0.6	-0.4	0.3	-0.4	-0.4	0.4	-0.4	0.6	0.4	0.4
Locomotion velocity, session 8	0.1	0.2	1.0	-0.4	-0.6	-0.3	1.0	-0.3	-0.4	0.2	-0.2	0.1	-0.1	-0.1
Locomotion distance, session 8	0.5	0.7	1.2	-1.1	-1.0	-0.9	1.0	-0.8	-0.8	0.7	-0.7	0.8	0.0	0.3
Degree of sensitization distance	0.3	0.4	1.0	0.4	0.3	0.5	-0.7	0.3	0.4	-0.8	0.7	-0.7	-0.2	-1.0
Degree of sensitization stereotypy	0.5	0.6	1.8	-1.3	-0.7	-0.6	0.5	-0.5	-0.5	0.9	-0.9	0.9	0.2	0.9
Conditioned locomotion	0.1	0.1	0.5	-0.3	-0.1	-0.1	0.4	-0.0	-0.1	-0.2	0.2	-0.2	-0.6	-0.7
Cocaine response after cond. corrected	0.7	1.1	5.8	0.6	0.5	1.2	-2.4	1.0	1.2	-0.8	0.7	-0.6	-0.0	-0.1
Cocaine response after cond. not corrected	0.2	0.3	0.8	-0.9	-0.6	-0.3	-0.8	-0.4	-0.2	0.4	-0.4	0.5	0.7	0.5
Cocaine response before conditioning	5.2	6.2	11.3	-3.1	-2.1	-3.0	3.4	-2.8	-2.7	2.4	-2.2	2.2	1.4	1.1
Saline control response	1.1	1.5	6.7	-1.7	-0.6	-1.3	2.6	-1.0	-1.0	1.1	-0.9	1.0	0.1	0.5
Bone: connectivity density	0.1	0.1	0.3	-0.3	0.3	-0.1	0.5	0.0	-0.1	0.4	-0.3	0.4	-0.4	0.5
Bone: cortical apparent density	0.2	0.2	1.5	0.5	0.0	0.4	-1.2	0.2	0.3	-0.4	0.4	-0.4	0.2	-0.4
Bone: cortical area	0.8	1.2	4.3	-1.5	-0.8	-1.3	2.1	-1.1	-1.1	1.0	-0.9	0.8	0.3	0.4
Bone: cortical porosity	0.3	0.3	0.5	0.0	0.4	0.6	-0.2	0.6	0.7	-0.5	0.6	-0.6	-0.7	-0.7
Bone: cortical porosity	0.1	0.1	0.2	-0.4	0.1	0.3	0.0	0.3	0.4	-0.2	0.2	-0.3	-0.3	-0.4
Bone: cortical thickness	0.4	0.6	1.1	0.6	0.8	0.7	0.2	0.7	0.7	-0.8	1.0	-1.0	-1.0	-1.1
Bone: cortical thickness	0.1	0.2	0.6	-0.8	-0.6	-0.5	-0.2	-0.4	-0.4	0.5	-0.3	0.3	0.1	-0.0
Bone: cortical tissue density	0.2	0.2	1.5	0.6	0.0	0.4	-1.2	0.2	0.3	-0.4	0.4	-0.4	0.3	-0.3
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	-0.2	0.1	0.3	-0.3	0.2	0.4	-0.3	0.4	-0.4	-0.1	-0.7
Condit. Reinf. active-inactive response ratio	1.2	1.3	2.3	0.5	1.1	1.1	-0.9	1.1	1.2	-1.1	1.3	-1.3	-1.2	-1.5
Condit. Reinf. active responses	0.2	0.3	0.6	-0.8	-0.7	-0.5	0.4	-0.6	-0.4	0.6	-0.5	0.5	0.7	0.2
Condit. Reinf. inactive responses	2.4	3.2	3.9	-1.3	-2.0	-1.8	1.6	-1.8	-1.8	1.8	-1.8	1.9	1.9	1.8
Incentive salience index mean	0.1	0.1	0.6	-0.7	-0.5	-0.4	0.1	-0.4	-0.3	0.3	-0.1	0.1	0.3	-0.4
Condit. Reinf. lever presses	0.4	0.5	1.2	-1.1	-1.0	-1.0	0.0	-0.9	-0.9	0.7	-0.5	0.5	0.5	-0.1
Condit. Reinf. active minus inactive responses	2.7	4.1	5.9	-1.5	-1.9	-2.2	2.4	-2.2	-2.2	2.1	-2.1	2.0	1.8	1.8
Condit. Reinf. active-inactive response ratio	2.5	3.9	4.5	-1.6	-2.0	-2.0	1.7	-2.1	-2.1	2.0	-2.1	2.1	2.1	2.0
Condit. Reinf. active responses	2.8	4.0	8.3	-1.4	-1.8	-2.2	2.9	-2.1	-2.2	2.1	-2.0	1.8	1.5	1.5
Condit. Reinf. inactive responses	0.2	0.3	2.1	-0.0	-0.1	-0.4	1.5	-0.3	-0.4	0.4	-0.0	-0.2	-0.5	-0.3
Condit. Reinf. lever presses	0.2	0.3	2.2	-0.5	0.0	-0.4	1.5	-0.3	-0.3	0.3	-0.2	0.1	-0.4	-0.2
Condit. Reinf. lever reinforcers received	3.9	5.4	10.9	-1.8	-2.1	-2.6	3.3	-2.5	-2.6	2.4	-2.3	2.2	1.7	1.8
Conditioned reinforcement - actives	0.1	0.3	1.5	-1.2	-0.9	-0.0	-0.6	-0.2	0.1	0.0	-0.1	0.1	-0.1	-0.4
Conditioned reinforcement - inactives	0.5	1.4	3.5	-1.6	-1.9	-1.3	0.5	-1.4	-1.3	1.0	-1.0	0.9	0.6	0.2
Conditioned locomotion	0.1	0.2	1.0	-0.2	-0.4	0.3	-1.0	0.1	0.3	-0.3	0.2	-0.2	0.0	-0.4
Patch foraging indifference point 0 sec	0.4	1.0	2.5	0.5	1.1	0.7	0.1	0.8	0.7	-1.0	1.2	-1.0	-1.5	-1.6
Patch foraging indifference point AUC	0.2	0.6	0.8	-0.8	0.8	0.6	-0.9	0.8	0.9	-0.8	0.6	-0.5	-0.8	-0.6
Delay disc. indifference point, 0s delay	0.2	0.2	1.3	0.3	0.3	-0.6	1.1	-0.4	-0.7	0.0	0.0	-0.0	-0.1	-0.4
Delay disc. indifference point, 16s delay	1.2	1.7	4.6	1.6	1.2	1.6	-2.1	1.3	1.4	-1.2	1.0	-0.9	0.4	-0.3
Delay disc. indifference point, 2s delay	0.7	0.7	1.5	1.1	0.6	0.6	-1.2	0.6	0.5	-0.8	0.9	-1.0	-0.9	-1.1
Delay disc. indifference point, 24s delay	0.7	1.1	2.7	0.8	0.9	1.1	-1.7	1.0	1.2	-1.1	0.9	-1.0	-0.4	-0.8
Delay disc. indifference point, 4s delay	0.1	0.1	0.1	-0.1	-0.1	-0.4	0.1	-0.3	-0.3	0.3	-0.2	0.2	0.3	0.1
Delay disc. indifference point, 8s delay	0.9	1.5	2.5	1.6	1.0	1.0	-1.3	1.0	0.9	-1.3	1.3	-1.3	-1.1	-1.4
Indifference point function ln k	1.8	5.3	8.4	-1.1	-2.9	-2.6	2.7	-2.8	-2.9	2.2	-2.2	1.9	2.0	1.4
Indifference point function log k	1.8	5.3	8.4	-1.1	-2.9	-2.6	2.7	-2.8	-2.9	2.2	-2.2	1.9	2.0	1.4
Patch foraging total patch changes 0 sec	0.4	1.1	3.0	0.5	1.1	0.7	-0.1	0.8	0.8	-1.0	1.3	-1.1	-1.6	-1.7
Patch foraging total patch changes 12 sec	0.3	0.4	0.9	-0.4	0.9	0.6	-0.4	0.7	0.8	-0.6	0.6	-0.4	-0.7	-0.5
Patch foraging total patch changes 18 sec	0.3	0.7	1.6	-0.3	1.3	0.6	0.3	0.8	0.9	-0.9	0.9	-0.6	-1.1	-0.9
Patch foraging total patch changes 24 sec	0.1	0.3	0.9	-1.0	0.2	-0.0	-0.1	0.1	0.2	0.4	-0.4	0.7	0.6	0.8
Patch foraging total patch changes 6 sec	1.0	1.7	2.1	0.3	1.4	1.3	-1.1	1.3	1.4	-1.3	1.4	-1.4	-1.4	-1.5
Patch foraging time to switch 0 sec	1.0	3.8	7.9	2.8	1.8	2.7	-2.3	2.4	2.5	-1.6	1.3	-1.3	0.2	0.4
Patch foraging water rate 0 sec	0.3	1.2	3.7	-1.9	-0.8	-1.5	1.4	-1.2	-1.2	0.7	-0.6	0.7	-0.4	-0.4
Patch foraging water rate 12 sec	0.5	1.8	4.5	-1.2	-1.5	-1.9	2.1	-1.8	-1.9	0.8	-0.8	0.5	-0.1	-0.4
Patch foraging water rate 18 sec	0.2	0.5	0.9	-0.6	-0.9	-0.9	0.9	-0.9	-0.9	0.3	-0.2	0.1	-0.5	-0.6
Patch foraging water rate 24 sec	0.7	1.0	2.0	-0.7	-0.9	-1.2	1.4	-1.2	-1.2	0.9	-0.9	0.9	0.4	0.6
Patch foraging water rate 6 sec	5.9	8.7	13.9	-3.7	-3.0	-3.4	2.9	-3.3	-3.1	2.9	-2.9	2.8	2.1	1.9
Seeking ratio, delayed vs. immediate footshock	0.3	0.4	1.8	0.5	-0.0	-0.5	1.3	-0.3	-0.6	0.0	0.2	-0.2	-1.1	-0.6
Distance traveled before self-admin	0.6	1.3	2.9	-1.1	-1.1	-1.7	1.4	-1.5	-1.7	0.8	-0.6	0.6	-0.2	-0.7
Distance traveled after self-admin	0.4	0.8	2.6	0.8	0.9	-0.0	0.9	0.3	-0.1	-0.7	0.9	-0.8	-1.6	-1.3
Extensor digitorum longus weight	0.2	0.8	5.0	-2.2	-0.7	-1.0	0.6	-0.8	-0.6	0.8	-0.6	0.4	-0.2	-0.3
Bone: elastic displacement	1.2	1.5	3.9	2.0	1.6	1.2	-0.5	1.1	1.0	-1.4	1.2	-1.2	-0.7	-0.8
Bone: elastic work	0.1	0.1	0.3	0.1	0.3	-0.3	0.6	-0.2	-0.3	0.0	0.1	-0.1	-0.2	-0.4
Bone: endosteal estimation	2.9	7.2	8.6	-2.8	-2.8	-2.8	2.2	-2.7	-2.7	2.8	-2.9	2.8	2.4	2.4
Bone: endosteal perimeter	1.5	3.7	4.3	-1.9	-1.9	-2.1	2.0	-2.0	-2.0	1.9	-2.1	2.0	1.6	1.7
Epididymis fat weight	0.1	0.3	0.8	0.8	0.2	0.6	-0.9	0.5	0.5	-0.0	-0.0	-0.0	0.7	0.8
Delta time in closed arm before/after self-admin	0.1	0.1	0.4	0.0	0.1	-0.1	0.6	-0.0	-0.1	0.1	-0.1	0.3	0.1	0.3
Delta time in open arm before/after self-admin	0.4	0.5	1.1	-1.0	-1.0	-0.8	0.3	-0.9	-0.8	0.6	-0.6	0.6	0.5	-0.1
Diff in mean of infusions in LGA sessions	0.2	0.4	1.4	0.7	0.1	0.2	-0.0	0.2	0.1	-0.6	0.7	-1.0	-1.0	-1.2
Delay discount exponential model param	0.8	1.1	1.7	-1.3	-1.1	-0.9	1.2	-0.8	-0.8	1.1	-1.1	1.1	0.8	1.2
Extinction: sum of active levers before priming	0.1	0.1	0.7	0.1	0.2	-0.2	0.8	-0.1	-0.2	0.2	-0.2	0.3	0.2	0.3
Active lever presses in extinction session 6	0.2	0.2	0.8	-0.8	-0.1	0.4	-0.9	0.3	0.6	0.1	-0.1	0.3	0.4	0.3
Bone: final force	2.0	3.2	5.3	-2.3	-1.7	-2.1	1.7	-2.0	-1.9	1.9	-1.7	1.6	1.3	1.0
Bone: final moment	2.6	4.2	6.6	-2.6	-1.9	-2.5	2.0	-2.3	-2.3	2.2	-2.0	1.9	1.4	1.2
Food consumed during 24 hour testing period	0.2	0.4	0.8	0.8	-0.8	-0.4	0.6	-0.7	-0.8	0.3	-0.3	0.2	0.9	0.3
Glucose	2.0	3.1	6.1	2.5	1.6	1.7	-1.4	1.6	1.4	-1.8	1.9	-2.0	-1.6	-1.8
Heart weight	0.2	0.3	1.2	-1.1	-0.6	-0.6	-0.0	-0.7	-0.5	0.2	-0.2	-0.0	0.3	-0.4
Delay discount hyperbolic model param	1.0	1.3	2.0	-1.3	-1.1	-0.9	1.3	-0.9	-0.9	1.2	-1.2	1.3	1.0	1.4
Intermittent access intake day 1-15 change	0.1	0.4	1.5	-1.2	-1.0	-0.5	-0.1	-0.7	-0.5	0.4	-0.5	0.3	0.5	0.1
Intermittent access intake escalation	0.1	0.7	2.3	-1.5	-1.3	-0.7	-0.1	-0.9	-0.6	0.6	-0.7	0.5	0.8	0.2
Intermittent access intake escalation 2	0.1	0.1	0.4	-0.4	-0.3	-0.2	0.1	-0.3	-0.2	-0.2	0.2	-0.2	-0.4	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.8	3.7	-1.1	-1.9	-0.4	-1.1	-0.7	-0.4	0.5	-0.5	0.5	0.9	-0.2
Intermitt. access day 15 inactive lever presses	0.3	1.9	4.4	-1.9	-2.1	-1.2	0.1	-1.4	-1.1	1.3	-1.3	1.3	1.5	0.9
Intermitt. access escalation Index	0.3	1.1	1.6	1.0	1.1	1.0	-1.3	1.0	1.0	-1.1	1.0	-1.1	-0.7	-0.8
Intermittent access day 1 total infusions	0.1	0.4	1.2	-1.1	-1.0	-0.5	-0.1	-0.5	-0.4	0.6	-0.6	0.6	0.4	0.3
Intermittent access day 15 total infusions	0.2	0.4	1.4	-1.0	-1.2	-0.1	-1.1	-0.4	-0.0	0.2	-0.3	0.1	0.5	-0.1
Intermittent access terminal intake (last 3 days)	0.2	0.4	1.7	-1.1	-1.3	-0.3	-0.7	-0.5	-0.3	0.3	-0.4	0.3	0.3	-0.1
Intermittent access total infusions	0.7	0.8	2.7	-1.6	-1.6	-0.6	-0.5	-0.8	-0.5	0.7	-0.8	0.7	0.5	0.2
Intermittent access day 1 locomotion	0.3	0.6	2.1	-0.5	-1.5	-0.6	-0.4	-0.8	-0.6	0.7	-0.8	0.8	0.9	0.7
Intermittent access day 15 total locomotion	0.1	0.4	2.0	-0.5	-1.4	-0.5	-0.4	-0.7	-0.6	0.0	-0.1	-0.0	-0.2	-0.9
Intermittent access total locomotion	1.4	1.7	5.6	-1.4	-2.4	-1.2	0.1	-1.5	-1.3	1.2	-1.2	1.1	1.1	0.6
Intermittent access standard deviation	0.3	1.5	3.0	0.6	0.6	1.0	-1.5	0.9	1.0	-1.3	1.3	-1.4	-1.4	-1.7
Left kidney weight	2.3	18.1	50.5	-7.1	-5.0	-4.8	3.5	-4.6	-4.2	3.9	-3.7	3.5	2.4	1.2
Right kidney weight	2.2	15.5	41.4	-6.4	-4.6	-4.4	3.0	-4.3	-3.8	3.7	-3.5	3.3	2.6	1.6
Cocaine induced anxiety	0.5	1.2	2.0	-0.6	-1.2	-1.0	1.1	-1.1	-1.1	1.1	-1.1	1.1	1.4	1.2
Post-drug Anxiety	1.0	1.2	2.7	-0.5	-1.1	-0.7	0.6	-0.8	-0.8	1.1	-1.2	1.2	1.7	1.6
Baseline Anxiety	0.2	0.4	1.3	1.2	0.8	0.7	-0.7	0.7	0.6	-0.5	0.4	-0.4	-0.2	0.1
Tail length	1.3	7.2	17.1	-4.1	-3.3	-3.0	2.1	-3.0	-2.7	2.6	-2.4	2.3	1.5	1.1
Length with tail	2.2	9.8	18.1	-4.2	-3.7	-3.3	2.5	-3.4	-3.1	3.1	-3.1	2.9	2.5	2.1
Length without tail	0.9	4.7	7.2	-2.5	-2.3	-2.0	1.4	-2.1	-1.8	2.1	-2.3	2.3	2.7	2.2
Times rat made contact with spout	0.2	0.2	1.0	1.0	0.5	0.4	0.4	0.4	0.3	-0.3	0.3	-0.4	-0.4	-0.0
Lifetime Intake	0.5	0.7	2.5	-1.6	-1.4	-0.6	-0.4	-0.7	-0.4	0.7	-0.7	0.6	0.5	0.2
Liver weight, left	1.1	2.0	9.8	-3.1	-1.3	-1.6	0.7	-1.5	-1.1	1.3	-1.0	0.9	0.4	-0.0
Liver weight, right	0.2	0.4	1.4	-1.2	0.0	-0.1	-0.2	0.0	0.1	-0.1	0.4	-0.5	-1.0	-1.1
Locomotor activity	0.3	0.5	1.6	-0.6	0.5	0.4	-0.9	0.6	0.7	-0.5	0.6	-0.8	-1.3	-0.9
Locomotor testing distance	0.1	0.1	0.9	-0.9	-0.1	0.0	-0.6	0.1	0.3	0.1	0.0	-0.2	-0.4	-0.2
Locomotor testing rearing	0.3	1.0	6.9	-2.6	-0.7	-1.0	0.7	-0.7	-0.6	0.7	-0.6	0.6	-0.4	-0.1
Locomotion in novel chamber	0.7	0.9	4.2	2.0	1.3	1.0	-0.8	0.9	0.8	-0.7	0.6	-0.6	-0.1	0.2
Locomotion in novel chamber post-restriction	0.3	0.8	2.1	1.4	1.3	0.9	-0.5	1.0	0.8	-1.0	0.8	-0.8	-0.8	-0.1
Fecal boli incidents, locomotor time 1	0.0	0.1	0.2	-0.2	-0.2	-0.4	0.4	-0.3	-0.4	-0.1	-0.1	0.2	-0.4	-0.3
Change in fecal boli incidents, locomotor task	2.3	2.4	3.4	1.8	1.4	1.6	-1.4	1.6	1.5	-1.5	1.6	-1.6	-1.5	-1.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	0.5	0.2	0.6	-0.8	0.5	0.6	-0.3	0.3	-0.4	-0.0	-0.0
Bouts of movement, locomotor time 1	0.2	0.3	0.9	0.5	-0.3	-0.6	0.9	-0.5	-0.7	-0.1	0.1	-0.1	-0.6	-0.5
Total resting periods, locomotor time 1	0.2	0.2	1.4	1.2	0.1	-0.0	0.5	-0.0	-0.3	-0.3	0.3	-0.3	-0.4	-0.2
Rest time, locomotor task time 1	0.7	1.2	2.2	-0.4	-1.0	-1.0	1.3	-1.1	-1.1	1.1	-1.1	1.2	0.9	1.5
Distance moved, locomotor task time 1	0.4	1.1	1.8	0.4	1.3	1.0	-1.1	1.0	1.1	-1.1	1.1	-1.2	-0.9	-1.3
Vertical activity count, locomotor time 1	0.5	3.4	6.6	1.1	1.9	1.4	-1.2	1.6	1.4	-1.9	2.0	-2.2	-2.4	-2.6
Time >=10cm from walls, locomotor time 2	0.1	0.4	0.7	0.6	0.6	0.8	-0.8	0.8	0.8	-0.4	0.4	-0.4	0.0	0.2
Bouts of movement, locomotor time 2	0.1	0.3	1.2	1.1	0.1	0.1	0.3	-0.0	-0.2	0.4	-0.3	0.2	0.7	0.8
Total resting periods, locomotor time 2	0.1	0.4	1.3	1.1	0.0	-0.1	0.6	-0.1	-0.3	0.5	-0.4	0.4	0.8	1.1
Rest time, locomotor task time 2	0.1	0.2	0.9	0.6	-0.1	-0.3	0.9	-0.2	-0.5	0.3	-0.2	0.2	0.1	0.6
Distance moved, locomotor task time 2	0.1	0.1	0.5	-0.7	0.5	0.0	-0.2	0.1	0.2	-0.2	0.2	-0.3	-0.4	-0.6
Vertical activity count, locomotor time 2	0.2	0.4	1.4	-0.3	0.8	0.1	-0.1	0.3	0.3	-0.4	0.5	-0.6	-1.2	-1.1
Light reinforcement 1	0.1	0.2	0.7	-0.8	-0.0	-0.6	0.7	-0.4	-0.4	0.3	-0.1	0.0	-0.6	-0.5
Light reinforcement 2	0.3	0.8	1.3	0.1	1.1	0.9	-0.8	0.9	1.0	-0.8	0.8	-0.9	-0.9	-1.0
Bone: marrow area	3.0	7.2	8.7	-2.9	-2.8	-2.8	2.2	-2.8	-2.7	2.8	-2.9	2.8	2.3	2.4
Bone: maximum diameter	0.8	1.6	5.4	-2.3	-1.0	-1.4	1.8	-1.2	-1.1	1.0	-1.0	1.0	0.2	0.2
Bone: maximum force	1.8	3.5	5.3	-2.1	-1.7	-2.2	2.3	-2.1	-2.0	2.0	-1.7	1.6	1.3	1.0
Bone: maximum moment	2.3	4.3	6.3	-2.4	-1.9	-2.4	2.5	-2.3	-2.3	2.2	-2.0	1.8	1.4	1.2
Mean time between licks in bursts	0.2	1.1	2.1	0.5	1.0	0.8	-1.1	0.9	0.8	-0.8	1.2	-1.2	-1.3	-1.4
Mean num. licks in bursts	0.1	0.2	1.3	1.2	-0.2	0.1	0.4	0.1	-0.1	0.1	-0.1	0.0	-0.0	0.3
Cd content in liver	1.1	1.2	2.0	-0.4	-1.0	-1.1	0.7	-1.2	-1.2	0.9	-1.1	1.3	1.4	1.2
Co content in liver	0.5	0.5	1.0	-0.2	-0.8	-0.8	0.6	-0.9	-0.9	0.5	-0.7	0.7	1.0	0.6
Cu content in liver	2.1	2.4	4.1	-2.0	-1.6	-1.5	0.8	-1.5	-1.3	1.6	-1.6	1.8	1.7	1.4
Fe content in liver	0.5	0.6	3.4	-1.8	-0.7	-0.7	0.2	-0.7	-0.4	0.7	-0.7	0.7	0.7	0.3
K content in liver	0.2	0.2	1.3	-1.2	-0.4	-0.5	0.5	-0.4	-0.3	0.2	-0.3	0.6	0.1	0.2
Mg content in liver	0.1	0.1	0.9	-1.0	-0.1	-0.0	-0.3	0.0	0.2	-0.1	-0.0	0.2	0.1	0.1
Mn content in liver	0.0	0.0	0.2	-0.4	-0.2	0.2	-0.1	0.2	0.3	-0.1	0.1	-0.0	0.2	-0.1
Na content in liver	0.6	0.6	1.1	0.3	0.8	0.9	-0.8	1.0	1.0	-0.9	0.8	-0.6	-0.8	-0.6
Rb content in liver	3.3	3.9	4.9	-2.2	-2.2	-1.9	1.5	-1.9	-1.8	1.9	-2.0	2.1	2.1	1.8
Se content in liver	2.1	2.5	4.3	-0.8	1.4	1.3	-1.7	1.5	1.7	-1.4	1.6	-1.6	-1.9	-2.1
Sr content in liver	7.3	6.3	8.9	2.5	2.7	2.3	-1.5	2.4	2.2	-2.6	2.7	-2.7	-3.0	-2.7
Zn content in liver	0.3	0.4	2.0	-0.4	0.4	0.6	-1.4	0.6	0.8	-0.4	0.3	-0.2	-0.1	-0.2
Bone: minimum diameter	3.1	5.9	10.8	-2.6	-2.0	-2.7	3.3	-2.5	-2.6	2.3	-2.4	2.4	1.6	1.8
Time in familiar zone, hab. session 1	2.1	2.4	4.3	-1.5	-1.4	-2.1	1.2	-1.9	-2.0	1.7	-1.4	1.4	0.9	0.6
Time in novel zone, hab. session 1	0.8	0.9	2.2	0.4	0.9	1.4	-0.6	1.3	1.5	-1.0	0.8	-0.8	-0.4	-0.2
Total zone transitions, hab. session 1	2.1	2.9	3.8	-1.8	-1.8	-1.9	1.9	-1.8	-1.9	1.7	-1.7	1.8	1.0	1.1
Total locomotion distance, hab. session 1	0.2	0.3	0.7	-0.1	-0.5	-0.8	0.6	-0.7	-0.8	0.4	-0.4	0.5	-0.0	0.2
Locomotion velocity, hab. session 1	0.1	0.2	0.5	0.3	-0.5	-0.5	0.3	-0.5	-0.7	0.3	-0.3	0.5	0.1	0.3
Time in familiar zone, hab. session 2	1.5	1.6	2.8	-0.8	-1.2	-1.2	0.4	-1.3	-1.2	1.6	-1.4	1.4	1.7	1.4
Time in novel zone, hab. session 2	0.5	0.6	0.9	0.3	0.6	0.9	-0.1	0.9	0.9	-1.0	0.8	-0.8	-0.9	-0.5
Total zone transitions, hab. session 2	2.4	3.1	5.0	-2.0	-1.8	-2.2	2.2	-2.0	-2.0	1.4	-1.5	1.7	0.6	0.8
Total locomotion distance, hab. session 2	0.1	0.2	0.6	0.6	0.2	-0.1	0.3	-0.0	-0.2	-0.4	0.3	-0.2	-0.8	-0.4
Locomotion velocity, hab. session 2	0.2	0.2	1.0	0.6	0.3	-0.1	0.3	0.1	-0.1	-0.5	0.4	-0.3	-1.0	-0.7
Novel to familiar place preference ratio	0.1	0.1	0.3	-0.4	0.2	-0.2	0.2	-0.0	-0.0	-0.2	0.2	-0.3	-0.6	-0.5
Novelty place preference	0.1	0.1	0.4	-0.6	-0.1	-0.4	0.5	-0.3	-0.3	0.1	-0.1	0.0	-0.2	-0.2
Time in novel zone, NPP test	0.1	0.1	0.4	-0.6	-0.2	-0.5	0.4	-0.4	-0.4	0.2	-0.2	0.1	-0.1	-0.1
Total zone transitions, NPP test	0.1	0.2	0.5	-0.5	-0.4	-0.6	0.7	-0.5	-0.6	0.3	-0.2	0.3	-0.2	-0.2
Total locomotion distance, NPP test	0.1	0.2	0.7	0.2	0.4	-0.0	0.3	0.1	0.0	-0.5	0.5	-0.3	-0.8	-0.8
Locomotion velocity, NPP test	0.1	0.2	0.6	0.0	0.3	-0.2	0.5	-0.0	-0.1	-0.4	0.4	-0.2	-0.8	-0.7
Intraocular pressure	0.1	0.2	0.5	0.1	-0.4	-0.1	0.5	-0.2	-0.2	0.4	-0.4	0.4	0.5	0.7
Delta distance traveled before/after self-admin	2.0	2.2	2.9	1.5	1.7	1.6	-0.8	1.6	1.5	-1.6	1.5	-1.5	-1.6	-1.2
Delta ambulatory time before/after self-admin	1.3	2.2	2.6	1.6	1.5	1.5	-0.8	1.5	1.4	-1.6	1.6	-1.5	-1.6	-1.4
Parametrial fat weight	2.6	6.2	7.3	2.5	2.4	2.5	-2.4	2.5	2.4	-2.7	2.7	-2.4	-2.4	-2.3
Pavlov. Cond. lever latency	0.1	0.2	0.7	0.8	0.2	0.2	0.7	0.1	0.0	-0.0	-0.1	0.1	0.4	0.6
Pavlov. Cond. magazine entry latency	0.8	1.1	1.9	0.2	1.0	0.9	-1.3	1.0	1.1	-0.9	1.0	-1.0	-1.4	-1.1
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.3	0.3	0.3	-0.7	0.4	0.3	-0.4	0.5	-0.5	-0.6	-0.6
Pavlov. Cond. index score	0.5	0.6	1.6	-0.4	0.5	0.4	-1.3	0.5	0.6	-0.6	0.7	-0.7	-1.1	-1.1
Pavlov. Cond. latency score	0.5	0.6	1.8	-0.1	0.5	0.4	-1.3	0.6	0.6	-0.6	0.8	-0.7	-1.1	-1.1
Pavlov. Cond. lever contacts	0.1	0.1	0.5	-0.7	-0.2	-0.1	-0.7	-0.1	-0.0	0.1	0.0	-0.0	-0.3	-0.4
Pavlov. Cond. magazine entry number	0.3	0.3	1.2	0.3	-0.4	-0.3	0.8	-0.5	-0.5	0.4	-0.5	0.5	1.1	0.6
Pavlov. Cond. intertrial magazine entries	0.2	0.3	1.6	0.0	-0.2	-0.5	1.2	-0.5	-0.6	0.4	-0.4	0.4	0.4	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.5	-0.4	0.5	0.4	-1.2	0.5	0.6	-0.6	0.7	-0.7	-1.1	-1.1
Pavlov. Cond. response bias	0.2	0.3	1.0	-1.0	0.1	0.0	-0.8	0.2	0.3	-0.1	0.2	-0.2	-0.8	-0.5
Pavlov. Cond. lever latency	0.9	1.3	3.7	-0.7	-1.5	-0.7	-0.4	-0.9	-0.8	1.0	-1.1	1.2	1.9	1.4
Pavlov. Cond. magazine entry latency	1.4	1.9	3.1	1.1	1.7	1.3	-0.3	1.4	1.3	-1.4	1.4	-1.5	-1.8	-1.5
Pavlov. Cond. change in total contacts	0.1	0.3	2.5	0.2	0.2	-0.4	1.6	-0.2	-0.4	0.2	-0.1	0.1	-0.4	-0.1
Pavlov. Cond. index score	0.4	0.6	1.8	0.5	1.1	0.5	0.6	0.7	0.5	-0.6	0.7	-0.8	-1.3	-0.9
Pavlov. Cond. latency score	0.9	1.4	3.0	1.0	1.6	1.0	0.1	1.1	1.0	-1.1	1.2	-1.3	-1.7	-1.4
Pavlov. Cond. lever contacts	0.5	0.8	2.6	0.3	1.2	0.4	0.8	0.6	0.5	-0.7	0.8	-0.9	-1.6	-1.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.6	-1.2	-1.3	-1.0	0.3	-1.0	-0.9	0.8	-0.9	1.0	1.1	0.8
Pavlov. Cond. intertrial magazine entries	2.7	5.8	6.8	-2.1	-2.4	-2.5	1.6	-2.6	-2.5	2.5	-2.5	2.6	2.6	2.4
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.7	1.9	0.4	1.2	0.5	0.4	0.7	0.6	-0.6	0.8	-0.8	-1.4	-1.0
Pavlov. Cond. response bias	0.2	0.3	1.7	-0.2	0.5	-0.2	1.3	-0.0	-0.1	0.0	0.1	-0.2	-0.9	-0.4
Time in closed arm before self-admin	0.1	0.2	1.1	-0.5	-1.0	-0.3	-0.4	-0.5	-0.3	0.1	-0.1	-0.0	-0.1	-0.6
Time in closed arm after self-admin	0.1	0.1	0.2	0.2	-0.4	-0.0	0.1	-0.2	-0.1	0.2	-0.3	0.2	0.4	0.4
Time in open arm before self-admin	0.5	0.6	2.6	0.9	1.6	0.7	0.4	0.9	0.7	-0.6	0.6	-0.5	-0.4	0.1
Time in open arm after self-admin	0.0	0.0	0.4	0.1	0.6	0.1	0.1	0.2	0.1	-0.1	0.2	-0.0	-0.0	0.0
Bone: periosteal estimation	2.3	5.4	7.3	-2.7	-2.2	-2.6	2.7	-2.4	-2.4	2.4	-2.4	2.3	1.6	1.8
Bone: periosteal perimeter	2.4	4.8	7.3	-2.2	-1.7	-2.3	2.7	-2.1	-2.2	2.3	-2.3	2.3	1.7	2.1
Bone: post-yield work	2.5	4.3	5.3	-1.6	-2.2	-1.9	2.2	-2.0	-1.9	2.2	-2.2	2.0	2.3	2.3
Progressive ratio test 1 active lever presses	0.4	0.8	2.0	-1.4	-1.0	-1.1	0.8	-1.0	-1.0	0.8	-0.7	0.7	0.3	0.1
Progressive ratio test 1 breakpoint	0.4	0.7	1.7	-1.3	-1.0	-1.0	0.8	-0.9	-0.9	0.8	-0.7	0.7	0.3	0.1
Progressive ratio test 1 inactive lever presses	1.0	2.5	5.6	-2.3	-2.4	-1.6	0.5	-1.7	-1.5	1.6	-1.5	1.4	1.2	0.7
Progressive ratio test 2 active lever presses	0.2	0.3	1.5	-1.2	-1.0	-0.1	-0.7	-0.3	0.1	0.1	-0.1	0.2	0.2	-0.4
Progressive ratio test 2 breakpoint	0.3	0.4	1.8	-1.4	-1.1	-0.2	-0.6	-0.4	-0.0	0.2	-0.3	0.3	0.3	-0.2
Progressive ratio test 2 inactive lever presses	0.9	2.8	6.5	-2.6	-2.6	-1.7	0.6	-1.8	-1.6	1.5	-1.5	1.5	1.2	0.5
Incentive Sensitization - Responses	0.2	0.5	2.1	-1.3	-1.4	-0.3	-0.2	-0.6	-0.2	0.4	-0.5	0.5	0.9	0.1
Incentive Sensitization - Breakpoint	0.2	0.4	1.5	-1.2	-1.2	-0.1	-0.4	-0.4	-0.0	0.2	-0.3	0.3	0.7	-0.0
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.0	0.9	0.5	0.5	-0.5	0.4	0.4	-0.8	0.8	-0.8	-0.6	-1.0
Progressive ratio	0.0	0.1	0.5	0.2	0.1	-0.2	0.7	-0.1	-0.2	-0.1	0.2	-0.1	-0.5	-0.4
Food seeking constrained by brief footshock	1.4	1.7	4.9	0.9	0.8	-0.9	2.0	-0.4	-1.0	-0.6	0.9	-0.9	-2.2	-2.1
Seeking ratio, punishment vs. effort	0.1	0.3	0.8	-0.1	-0.4	-0.8	0.7	-0.7	-0.9	0.3	-0.3	0.2	-0.0	-0.2
Retroperitoneal fat weight	4.2	18.6	24.0	4.4	4.5	4.9	-4.9	4.7	4.7	-4.3	4.2	-4.2	-3.2	-2.9
Reaction time number correct	0.2	0.5	2.3	-0.5	0.9	0.1	-0.4	0.4	0.3	-0.5	0.6	-0.6	-1.5	-1.1
Reaction time mean minus median	0.0	0.1	0.4	0.5	-0.3	0.1	-0.5	0.0	0.0	0.1	-0.3	0.4	0.5	0.6
Reaction time mean minus median AUC	0.0	0.2	0.8	0.1	-0.0	-0.0	-0.3	-0.1	-0.1	0.3	-0.5	0.6	0.7	0.9
Reaction time num false alarms	0.4	0.7	3.1	-1.8	-0.1	-0.1	-0.7	0.1	0.3	-0.3	0.5	-0.4	-1.0	-1.5
Reaction time num false alarms AUC	0.3	0.8	2.8	-1.4	0.3	0.1	-0.7	0.3	0.5	-0.6	0.7	-0.7	-1.3	-1.7
Reaction time trials correct on left	0.2	0.5	2.3	-0.5	0.9	0.1	-0.4	0.4	0.3	-0.5	0.6	-0.6	-1.5	-1.1
Reaction time trials on left	0.2	0.5	2.3	-0.5	0.9	0.1	-0.4	0.4	0.3	-0.5	0.6	-0.6	-1.5	-1.1
Reaction time mean	0.4	1.0	2.8	-0.1	-1.7	-0.3	-0.4	-0.7	-0.6	0.7	-1.1	1.0	1.5	1.4
Reaction time mean AUC	0.2	0.5	1.5	0.3	-1.2	0.1	-0.9	-0.2	-0.1	0.3	-0.7	0.5	1.1	1.0
Median of all reaction times	0.6	0.9	2.8	-0.1	-1.7	-0.3	-0.4	-0.6	-0.5	0.7	-1.0	0.9	1.5	1.3
Reaction time omissions	0.0	0.1	0.2	0.3	-0.1	0.1	-0.1	0.1	0.1	-0.3	0.2	-0.3	-0.4	-0.5
Reaction time false alarm rate	0.2	0.2	1.0	-0.7	-0.2	0.2	-0.5	0.2	0.3	-0.4	0.4	-0.4	-0.4	-1.0
Reaction time premature initiation rate	0.2	0.3	1.8	1.4	0.1	0.6	-0.4	0.4	0.3	-0.7	0.5	-0.6	-0.1	-0.2
Reaction time premature initiations	0.2	0.7	1.4	1.2	0.7	0.7	-0.6	0.7	0.6	-1.0	0.8	-0.9	-0.9	-0.7
Std. dev. reaction times	0.1	0.4	1.1	0.2	-1.1	-0.1	-0.7	-0.3	-0.3	0.3	-0.6	0.6	0.9	0.7
Reaction time trials completed	0.2	0.5	2.3	-0.5	0.9	0.1	-0.4	0.4	0.3	-0.5	0.6	-0.6	-1.5	-1.1
Reaction time trials AUC	0.2	0.6	2.4	-0.6	0.9	0.1	-0.5	0.4	0.4	-0.5	0.6	-0.6	-1.6	-1.1
Run reversals in cocaine runway, females	0.2	0.3	1.5	1.2	-0.1	0.7	-0.1	0.3	0.4	-0.4	0.2	-0.2	0.7	0.2
Run reversals in cocaine runway, males	0.3	0.3	0.6	-0.8	-0.2	-0.4	0.3	-0.4	-0.3	0.7	-0.6	0.6	0.7	0.7
Latency to leave start box in cocaine runway	0.1	0.1	1.1	0.4	-0.2	-0.2	0.2	-0.4	-0.3	-0.0	-0.1	0.1	1.0	-0.1
Latency to leave start box in cocaine runway, F	0.2	0.2	0.7	0.9	0.5	0.3	0.1	0.2	0.3	-0.5	0.5	-0.6	0.4	-0.7
Latency to leave start box in cocaine runway, M	1.5	1.4	2.8	-1.0	-1.1	-1.2	0.6	-1.3	-1.1	1.1	-1.2	1.3	1.7	1.2
Std. dev. time between licks in bursts	0.1	0.2	0.6	-0.7	0.5	-0.3	-0.1	-0.2	-0.2	0.1	0.3	-0.1	-0.7	-0.8
Total sessions with >9 infusions	1.5	1.9	4.4	-2.1	-1.5	-1.5	1.0	-1.4	-1.3	1.4	-1.4	1.4	0.9	0.9
Short access day 1 total inactive lever presses	0.5	1.0	2.9	-1.7	-1.4	-0.8	-0.0	-0.9	-0.6	0.9	-1.0	1.0	1.0	0.8
Short access day 10 total inactive lever presses	0.0	0.1	0.6	0.2	-0.8	-0.1	-0.3	-0.3	-0.3	0.1	-0.1	0.2	0.5	0.1
Short access day 1 total infusions	0.1	0.3	1.0	-1.0	-0.3	-0.4	0.2	-0.4	-0.3	0.5	-0.5	0.5	0.4	0.5
Short access day 10 total infusions	0.1	0.2	1.5	-1.2	-0.2	-0.1	-0.5	0.0	0.2	-0.0	0.0	-0.0	-0.5	-0.6
Short access total infusions	0.1	0.1	0.8	-0.9	0.0	-0.0	-0.4	0.1	0.2	0.0	0.0	0.0	-0.4	-0.2
Short access day 1 locomotion	0.8	1.3	2.9	-1.7	-1.3	-0.9	0.6	-0.9	-0.7	1.1	-1.2	1.3	1.2	1.2
Short access day 10 total locomotion	0.2	0.7	2.1	-0.3	-1.4	-0.9	0.6	-1.1	-1.1	0.7	-0.7	0.6	0.5	0.2
Short access total locomotion	0.2	0.4	0.7	-0.7	-0.9	-0.8	0.5	-0.7	-0.8	0.4	-0.4	0.4	-0.3	-0.2
One hour access (0.3 mA shock)	2.0	2.3	7.7	-1.7	-2.8	-1.3	0.6	-1.6	-1.3	1.5	-1.5	1.3	1.5	0.7
Compulsive drug intake	1.2	1.8	3.1	-1.3	-1.8	-1.3	1.0	-1.4	-1.3	1.4	-1.4	1.2	1.6	1.0
One hour access (shock baseline)	0.1	0.2	0.8	-0.7	-0.9	0.2	-0.9	-0.0	0.2	0.0	-0.1	0.1	0.1	-0.2
Social response proportion	0.4	0.5	1.2	-0.9	-0.9	-0.4	-0.9	-0.7	-0.4	0.4	-0.5	0.4	1.1	0.3
Social responses	2.5	3.3	5.4	-2.3	-2.1	-1.8	0.5	-2.0	-1.7	1.9	-1.8	1.8	2.0	1.4
Social time	1.9	3.0	5.1	-1.6	-1.8	-2.3	1.5	-2.2	-2.3	1.7	-1.6	1.6	1.1	0.8
Soleus weight	0.1	0.2	0.7	-0.6	0.3	-0.1	-0.0	0.0	0.1	-0.0	0.3	-0.4	-0.7	-0.8
Bone: stiffness	2.0	3.6	7.9	-2.8	-2.1	-2.2	1.9	-2.1	-1.9	1.9	-1.7	1.6	1.3	0.9
Tibialis anterior weight	1.2	4.0	9.5	-0.3	2.1	1.5	-1.6	1.8	1.9	-1.6	1.9	-2.2	-3.1	-2.6
Time to tail flick, vehicle, before self-admin	0.1	0.1	0.7	-0.3	-0.3	-0.3	0.4	-0.2	-0.2	-0.2	0.2	-0.3	-0.2	-0.8
Time to tail flick, vehicle, after self-admin	0.3	0.7	2.2	-0.3	-1.0	-0.3	-0.0	-0.5	-0.4	0.7	-0.8	0.9	1.5	1.3
Time to tail flick, test, before self-admin	0.3	0.3	1.0	0.8	0.4	-0.4	1.0	-0.3	-0.6	-0.2	0.3	-0.4	-0.7	-0.7
Time to tail flick, test, after self-admin	0.2	0.2	0.4	0.6	0.5	0.6	-0.1	0.5	0.5	-0.5	0.4	-0.4	0.0	-0.2
Delta time to tail flick, vehicle, before/after SA	0.4	0.4	1.8	-0.0	-0.4	-0.1	-0.2	-0.2	-0.1	0.5	-0.6	0.8	1.0	1.3
Delta time to tail flick, test, before/after SA	0.2	0.2	0.7	-0.4	-0.3	0.4	-0.5	0.2	0.4	0.1	-0.2	0.3	0.8	0.6
Tibia length	3.2	8.9	17.8	-4.2	-2.9	-3.4	3.1	-3.2	-3.1	2.9	-2.8	2.9	2.0	1.7
Ambulatory time before self-admin	0.5	1.6	3.2	-1.2	-1.0	-1.8	1.7	-1.6	-1.8	1.1	-1.0	1.0	0.3	0.1
Ambulatory time after self-admin	0.3	0.5	1.4	0.5	0.3	-0.4	1.1	-0.2	-0.5	-0.4	0.5	-0.4	-1.2	-1.1
Bone: tissue strength	0.4	0.4	1.5	0.6	0.4	-0.1	0.3	0.0	-0.1	-0.5	0.7	-0.8	-0.9	-1.2
Total heroin consumption	0.1	0.1	0.3	0.2	0.4	0.2	0.0	0.3	0.3	-0.4	0.4	-0.3	-0.6	-0.5
Bone: trabecular number	0.0	0.1	0.2	0.0	0.3	-0.1	0.4	0.1	-0.0	0.3	-0.2	0.1	-0.4	0.3
Bone: trabecular spacing	0.0	0.0	0.1	0.2	0.4	0.0	0.1	0.0	0.0	-0.2	0.1	-0.1	-0.0	-0.2
Bone: trabecular thickness	0.0	0.0	0.3	-0.5	-0.1	-0.1	-0.2	-0.0	0.1	0.1	-0.1	0.2	0.2	0.2
Bone: trabecular tissue density	0.9	1.5	3.2	0.9	0.9	1.5	-1.8	1.3	1.5	-1.3	1.2	-1.2	-0.3	-0.9
Water consumed over 24 hours	0.4	0.7	2.0	-0.1	-0.7	-1.0	1.4	-1.0	-1.1	0.9	-0.8	0.5	0.5	0.5
Number of responses in last shaping day	0.2	0.3	1.4	-1.0	-0.3	0.1	-1.2	-0.0	0.3	0.2	-0.3	0.3	0.4	0.3