Hub : Genes

LOC108348449

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression LOC108348449 0.34 0.19 3.5e-04 0.01 0.05 0.04 0.06 1.6e-01 2.3e-02 3.2e-02 1.2e-02
2 PL gene expression LOC108348449 0.17 0.08 4.1e-14 0.12 0.13 0.12 0.13 1.4e-12 1.2e-13 3.9e-13 1.1e-13
3 LHb gene expression LOC108348449 0.29 0.17 6.9e-05 0.13 0.14 0.11 0.11 4.9e-04 4.3e-04 1.7e-03 1.5e-03
4 Liver alternative TSS XR_005498947.2 0.02 0.02 2.4e-03 0.01 0.01 0.01 0.01 7.6e-03 2.6e-02 7.7e-03 2.9e-02
5 Adipose gene expression LOC108348449 0.1 0.06 9.2e-11 0.05 0.08 0.07 0.07 1.3e-06 7.8e-09 2.6e-08 3.3e-08
6 Liver gene expression LOC108348449 0.08 0.04 1.6e-12 0.07 0.09 0.08 0.09 2.5e-08 2.3e-10 2.8e-09 1.1e-09
7 NAcc gene expression LOC108348449 0.27 0.1 0.0e+00 0.21 0.2 0.21 0.2 1.3e-30 1.1e-29 1.2e-30 2.5e-30
8 Brain gene expression LOC108348449 0.27 0.14 8.7e-15 0.17 0.15 0.17 0.17 1.5e-15 3.8e-14 2.9e-15 1.1e-15
9 pVTA gene expression LOC108348449 0.15 0.08 7.4e-06 0.05 0.04 0.03 0.05 8.7e-05 4.5e-04 3.6e-03 1.2e-04
10 IC gene expression LOC108348449 0.38 0.14 8.9e-07 0.15 0.17 0.18 0.14 8.7e-07 1.6e-07 7.2e-08 1.5e-06
11 BLA gene expression LOC108348449 0.38 0.16 4.6e-06 0.09 0.09 0.1 0.08 2.2e-05 2.2e-05 5.5e-06 4.3e-05

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bone: apparent density0.20.30.7-0.4-0.4-0.5-0.9-0.4-0.5-0.7-0.6-0.5-0.2-0.6
Area under the delay curve1.11.32.11.51.20.91.30.90.91.21.21.20.81.2
BMI with tail0.62.23.4-0.01.51.31.71.51.61.31.51.61.81.7
BMI without tail0.20.62.1-1.40.10.20.90.20.50.30.60.71.11.3
Body weight0.73.114.3-3.8-2.0-1.9-0.9-1.8-1.4-1.5-1.3-1.1-0.5-0.1
Weight adjusted by age0.40.71.5-1.2-0.6-1.1-1.1-0.9-1.0-0.7-0.6-0.6-0.2-0.1
Bone surface3.66.68.2-2.7-2.3-2.6-2.7-2.5-2.5-2.9-2.7-2.6-2.2-2.3
Bone volume3.15.66.9-2.3-2.1-2.4-2.5-2.3-2.3-2.6-2.5-2.4-2.2-2.3
Breakpoint value in progressive ratio session1.82.23.61.90.81.61.71.41.41.51.51.61.11.4
Number of licking bursts0.00.10.3-0.60.40.10.10.10.20.10.20.30.10.3
Context. condit. distance diff. score0.10.10.4-0.5-0.3-0.2-0.3-0.0-0.1-0.1-0.0-0.00.60.4
Locomotion velocity, session 10.30.30.7-0.0-0.4-0.7-0.4-0.7-0.9-0.4-0.5-0.7-0.5-0.4
Locomotion distance, session 12.32.95.8-1.3-1.6-2.1-2.4-2.0-2.1-1.3-1.5-1.7-1.3-0.9
Locomotion velocity, session 20.20.20.7-0.9-0.3-0.5-0.3-0.4-0.4-0.3-0.3-0.40.2-0.1
Locomotion distance, session 22.02.74.0-2.0-1.8-1.9-1.7-1.8-1.7-1.5-1.6-1.6-1.2-1.2
Locomotion velocity, session 30.10.10.3-0.6-0.2-0.2-0.6-0.2-0.1-0.4-0.4-0.5-0.1-0.3
Locomotion distance, session 31.11.22.4-0.9-0.8-1.1-1.6-0.9-1.1-1.3-1.2-1.3-0.3-1.1
Stereotopy head waving bouts, day 30.40.41.00.30.60.60.70.50.60.90.80.60.21.0
Stereotopy head waving duration, day 30.40.51.10.50.40.70.70.50.61.10.90.70.21.1
Locomotion velocity, session 70.40.41.60.2-0.7-0.4-1.3-0.5-0.6-0.3-0.4-0.5-0.7-0.6
Locomotion distance, session 70.10.10.3-0.0-0.3-0.3-0.5-0.3-0.3-0.3-0.2-0.2-0.20.0
Stereotopy head waving bouts, day 70.40.41.1-1.1-0.8-0.5-0.4-0.5-0.5-0.6-0.6-0.8-0.5-0.6
Stereotopy head waving duration, day 70.20.20.7-0.8-0.6-0.4-0.3-0.4-0.4-0.4-0.4-0.6-0.4-0.4
Locomotion velocity, session 80.10.21.0-0.4-0.6-0.3-1.0-0.3-0.4-0.2-0.2-0.10.10.1
Locomotion distance, session 80.50.71.2-1.1-1.0-0.9-1.0-0.8-0.8-0.7-0.7-0.8-0.0-0.3
Degree of sensitization distance0.30.41.00.40.30.50.70.30.40.80.70.70.21.0
Degree of sensitization stereotypy0.60.61.8-1.3-0.7-0.6-0.5-0.5-0.5-0.9-0.9-0.9-0.2-0.9
Conditioned locomotion0.10.10.5-0.3-0.1-0.1-0.4-0.0-0.10.20.20.20.60.7
Cocaine response after cond. corrected0.91.15.80.60.51.22.41.01.20.80.70.60.00.1
Cocaine response after cond. not corrected0.30.30.8-0.9-0.6-0.30.8-0.4-0.2-0.4-0.4-0.5-0.7-0.5
Cocaine response before conditioning5.26.211.3-3.1-2.1-3.0-3.4-2.8-2.7-2.4-2.2-2.2-1.4-1.1
Saline control response1.11.56.7-1.7-0.6-1.3-2.6-1.0-1.0-1.1-0.9-1.0-0.1-0.5
Bone: connectivity density0.10.10.3-0.30.3-0.1-0.50.0-0.1-0.4-0.3-0.40.4-0.5
Bone: cortical apparent density0.20.21.50.50.00.41.20.20.30.40.40.4-0.20.4
Bone: cortical area0.81.24.3-1.5-0.8-1.3-2.1-1.1-1.1-1.0-0.9-0.8-0.3-0.4
Bone: cortical porosity0.30.30.50.00.40.60.20.60.70.50.60.60.70.7
Bone: cortical porosity0.10.10.2-0.40.10.3-0.00.30.40.20.20.30.30.4
Bone: cortical thickness0.40.61.10.60.80.7-0.20.70.70.81.01.01.01.1
Bone: cortical thickness0.20.20.6-0.8-0.6-0.50.2-0.4-0.4-0.5-0.3-0.3-0.10.0
Bone: cortical tissue density0.20.21.50.60.00.41.20.20.30.40.40.4-0.30.3
Condit. Reinf. active minus inactive responses0.10.10.5-0.20.10.30.30.20.40.30.40.40.10.7
Condit. Reinf. active-inactive response ratio1.21.32.30.51.11.10.91.11.21.11.31.31.21.5
Condit. Reinf. active responses0.30.30.6-0.8-0.7-0.5-0.4-0.6-0.4-0.6-0.5-0.5-0.7-0.2
Condit. Reinf. inactive responses2.63.23.9-1.3-2.0-1.8-1.6-1.8-1.8-1.8-1.8-1.9-1.9-1.8
Incentive salience index mean0.10.10.6-0.7-0.5-0.4-0.1-0.4-0.3-0.3-0.1-0.1-0.30.4
Condit. Reinf. lever presses0.40.51.2-1.1-1.0-1.0-0.0-0.9-0.9-0.7-0.5-0.5-0.50.1
Condit. Reinf. active minus inactive responses3.24.15.9-1.5-1.9-2.2-2.4-2.2-2.2-2.1-2.1-2.0-1.8-1.8
Condit. Reinf. active-inactive response ratio3.43.94.5-1.6-2.0-2.0-1.7-2.1-2.1-2.0-2.1-2.1-2.1-2.0
Condit. Reinf. active responses2.94.08.3-1.4-1.8-2.2-2.9-2.1-2.2-2.1-2.0-1.8-1.5-1.5
Condit. Reinf. inactive responses0.20.32.1-0.0-0.1-0.4-1.5-0.3-0.4-0.4-0.00.20.50.3
Condit. Reinf. lever presses0.20.32.2-0.50.0-0.4-1.5-0.3-0.3-0.3-0.2-0.10.40.2
Condit. Reinf. lever reinforcers received3.95.410.9-1.8-2.1-2.6-3.3-2.5-2.6-2.4-2.3-2.2-1.7-1.8
Conditioned reinforcement - actives0.20.31.5-1.2-0.9-0.00.6-0.20.1-0.0-0.1-0.10.10.4
Conditioned reinforcement - inactives0.91.43.5-1.6-1.9-1.3-0.5-1.4-1.3-1.0-1.0-0.9-0.6-0.2
Conditioned locomotion0.10.21.0-0.2-0.40.31.00.10.30.30.20.2-0.00.4
Patch foraging indifference point 0 sec0.61.02.50.51.10.7-0.10.80.71.01.21.01.51.6
Patch foraging indifference point AUC0.40.60.8-0.80.80.60.90.80.90.80.60.50.80.6
Delay disc. indifference point, 0s delay0.20.21.30.30.3-0.6-1.1-0.4-0.7-0.00.00.00.10.4
Delay disc. indifference point, 16s delay1.51.74.61.61.21.62.11.31.41.21.00.9-0.40.3
Delay disc. indifference point, 2s delay0.70.71.51.10.60.61.20.60.50.80.91.00.91.1
Delay disc. indifference point, 24s delay0.91.12.70.80.91.11.71.01.21.10.91.00.40.8
Delay disc. indifference point, 4s delay0.10.10.1-0.1-0.1-0.4-0.1-0.3-0.3-0.3-0.2-0.2-0.3-0.1
Delay disc. indifference point, 8s delay1.31.52.51.61.01.01.31.00.91.31.31.31.11.4
Indifference point function ln k3.05.38.4-1.1-2.9-2.6-2.7-2.8-2.9-2.2-2.2-1.9-2.0-1.4
Indifference point function log k3.05.38.4-1.1-2.9-2.6-2.7-2.8-2.9-2.2-2.2-1.9-2.0-1.4
Patch foraging total patch changes 0 sec0.61.13.00.51.10.70.10.80.81.01.31.11.61.7
Patch foraging total patch changes 12 sec0.30.40.9-0.40.90.60.40.70.80.60.60.40.70.5
Patch foraging total patch changes 18 sec0.50.71.6-0.31.30.6-0.30.80.90.90.90.61.10.9
Patch foraging total patch changes 24 sec0.10.30.9-1.00.2-0.00.10.10.2-0.4-0.4-0.7-0.6-0.8
Patch foraging total patch changes 6 sec1.11.62.10.31.41.31.11.31.41.31.41.41.41.5
Patch foraging time to switch 0 sec1.93.87.92.81.82.72.32.42.51.61.31.3-0.2-0.4
Patch foraging water rate 0 sec0.61.23.7-1.9-0.8-1.5-1.4-1.2-1.2-0.7-0.6-0.70.40.4
Patch foraging water rate 12 sec0.91.84.5-1.2-1.5-1.9-2.1-1.8-1.9-0.8-0.8-0.50.10.4
Patch foraging water rate 18 sec0.30.50.9-0.6-0.9-0.9-0.9-0.9-0.9-0.3-0.2-0.10.50.6
Patch foraging water rate 24 sec0.71.02.0-0.7-0.9-1.2-1.4-1.2-1.2-0.9-0.9-0.9-0.4-0.6
Patch foraging water rate 6 sec6.08.713.9-3.7-3.0-3.4-2.9-3.3-3.1-2.9-2.9-2.8-2.1-1.9
Seeking ratio, delayed vs. immediate footshock0.30.41.80.5-0.0-0.5-1.3-0.3-0.6-0.00.20.21.10.6
Distance traveled before self-admin1.01.32.9-1.1-1.1-1.7-1.4-1.5-1.7-0.8-0.6-0.60.20.7
Distance traveled after self-admin0.60.82.60.80.9-0.0-0.90.3-0.10.70.90.81.61.3
Extensor digitorum longus weight0.20.85.0-2.2-0.7-1.0-0.6-0.8-0.6-0.8-0.6-0.40.20.3
Bone: elastic displacement1.31.53.92.01.61.20.51.11.01.41.21.20.70.8
Bone: elastic work0.10.10.30.10.3-0.3-0.6-0.2-0.3-0.00.10.10.20.4
Bone: endosteal estimation3.37.28.6-2.8-2.8-2.8-2.2-2.7-2.7-2.8-2.9-2.8-2.4-2.4
Bone: endosteal perimeter1.73.74.3-1.9-1.9-2.1-2.0-2.0-2.0-1.9-2.1-2.0-1.6-1.7
Epididymis fat weight0.10.30.80.80.20.60.90.50.50.0-0.00.0-0.7-0.8
Delta time in closed arm before/after self-admin0.10.10.40.00.1-0.1-0.6-0.0-0.1-0.1-0.1-0.3-0.1-0.3
Delta time in open arm before/after self-admin0.50.51.1-1.0-1.0-0.8-0.3-0.9-0.8-0.6-0.6-0.6-0.50.1
Diff in mean of infusions in LGA sessions0.40.41.40.70.10.20.00.20.10.60.71.01.01.2
Delay discount exponential model param1.01.11.7-1.3-1.1-0.9-1.2-0.8-0.8-1.1-1.1-1.1-0.8-1.2
Extinction: sum of active levers before priming0.10.10.70.10.2-0.2-0.8-0.1-0.2-0.2-0.2-0.3-0.2-0.3
Active lever presses in extinction session 60.20.20.8-0.8-0.10.40.90.30.6-0.1-0.1-0.3-0.4-0.3
Bone: final force2.03.25.3-2.3-1.7-2.1-1.7-2.0-1.9-1.9-1.7-1.6-1.3-1.0
Bone: final moment2.64.26.6-2.6-1.9-2.5-2.0-2.3-2.3-2.2-2.0-1.9-1.4-1.2
Food consumed during 24 hour testing period0.30.40.80.8-0.8-0.4-0.6-0.7-0.8-0.3-0.3-0.2-0.9-0.3
Glucose2.03.16.12.51.61.71.41.61.41.81.92.01.61.8
Heart weight0.20.31.2-1.1-0.6-0.60.0-0.7-0.5-0.2-0.20.0-0.30.4
Delay discount hyperbolic model param1.21.32.0-1.3-1.1-0.9-1.3-0.9-0.9-1.2-1.2-1.3-1.0-1.4
Intermittent access intake day 1-15 change0.20.41.5-1.2-1.0-0.50.1-0.7-0.5-0.4-0.5-0.3-0.5-0.1
Intermittent access intake escalation0.30.72.3-1.5-1.3-0.70.1-0.9-0.6-0.6-0.7-0.5-0.8-0.2
Intermittent access intake escalation 20.10.10.4-0.4-0.3-0.2-0.1-0.3-0.20.20.20.20.40.6
Intermitt. access day 1 inactive lever presses0.20.83.7-1.1-1.9-0.41.1-0.7-0.4-0.5-0.5-0.5-0.90.2
Intermitt. access day 15 inactive lever presses0.91.94.4-1.9-2.1-1.2-0.1-1.4-1.1-1.3-1.3-1.3-1.5-0.9
Intermitt. access escalation Index0.71.11.61.01.11.01.31.01.01.11.01.10.70.8
Intermittent access day 1 total infusions0.20.41.2-1.1-1.0-0.50.1-0.5-0.4-0.6-0.6-0.6-0.4-0.3
Intermittent access day 15 total infusions0.30.41.4-1.0-1.2-0.11.1-0.4-0.0-0.2-0.3-0.1-0.50.1
Intermittent access terminal intake (last 3 days)0.30.41.7-1.1-1.3-0.30.7-0.5-0.3-0.3-0.4-0.3-0.30.1
Intermittent access total infusions0.70.82.7-1.6-1.6-0.60.5-0.8-0.5-0.7-0.8-0.7-0.5-0.2
Intermittent access day 1 locomotion0.50.62.1-0.5-1.5-0.60.4-0.8-0.6-0.7-0.8-0.8-0.9-0.7
Intermittent access day 15 total locomotion0.20.42.0-0.5-1.4-0.50.4-0.7-0.6-0.0-0.10.00.20.9
Intermittent access total locomotion1.41.75.6-1.4-2.4-1.2-0.1-1.5-1.3-1.2-1.2-1.1-1.1-0.6
Intermittent access standard deviation0.71.53.00.60.61.01.50.91.01.31.31.41.41.7
Left kidney weight3.918.150.5-7.1-5.0-4.8-3.5-4.6-4.2-3.9-3.7-3.5-2.4-1.3
Right kidney weight3.415.541.4-6.4-4.6-4.4-3.0-4.3-3.8-3.7-3.5-3.3-2.6-1.6
Cocaine induced anxiety0.91.22.0-0.6-1.2-1.0-1.1-1.1-1.1-1.1-1.1-1.1-1.4-1.2
Post-drug Anxiety1.11.22.7-0.5-1.1-0.7-0.6-0.8-0.8-1.1-1.2-1.2-1.7-1.6
Baseline Anxiety0.30.41.31.20.80.70.70.70.60.50.40.40.2-0.1
Tail length1.97.217.1-4.1-3.3-3.0-2.1-3.0-2.7-2.6-2.4-2.3-1.5-1.1
Length with tail2.29.818.1-4.2-3.7-3.3-2.5-3.4-3.1-3.1-3.1-2.9-2.5-2.1
Length without tail1.54.77.2-2.5-2.3-2.0-1.4-2.1-1.8-2.1-2.3-2.3-2.7-2.3
Times rat made contact with spout0.20.21.01.00.50.4-0.40.40.30.30.30.40.40.0
Lifetime Intake0.50.72.5-1.6-1.4-0.60.4-0.7-0.4-0.7-0.7-0.6-0.5-0.2
Liver weight, left1.22.09.8-3.1-1.3-1.6-0.7-1.5-1.1-1.3-1.0-0.9-0.40.0
Liver weight, right0.20.41.4-1.20.0-0.10.20.00.10.10.40.51.01.1
Locomotor activity0.30.51.6-0.60.50.40.90.60.70.50.60.81.30.9
Locomotor testing distance0.10.10.9-0.9-0.10.00.60.10.3-0.10.00.20.40.1
Locomotor testing rearing0.51.06.9-2.6-0.7-1.0-0.7-0.7-0.6-0.7-0.6-0.60.40.1
Locomotion in novel chamber0.70.94.22.01.31.00.80.90.80.70.60.60.1-0.2
Locomotion in novel chamber post-restriction0.50.82.11.41.30.90.51.00.81.00.80.80.80.1
Fecal boli incidents, locomotor time 10.10.10.2-0.2-0.2-0.4-0.4-0.3-0.40.1-0.1-0.20.40.3
Change in fecal boli incidents, locomotor task2.42.43.41.81.41.61.41.61.51.51.61.61.51.3
Time >=10cm from walls, locomotor time 10.20.20.60.50.20.60.80.50.60.30.30.40.00.1
Bouts of movement, locomotor time 10.20.30.90.5-0.3-0.6-0.9-0.5-0.70.10.10.10.60.5
Total resting periods, locomotor time 10.20.21.41.20.1-0.0-0.5-0.0-0.30.30.30.30.40.3
Rest time, locomotor task time 11.01.22.2-0.4-1.0-1.0-1.3-1.1-1.1-1.1-1.1-1.2-0.9-1.5
Distance moved, locomotor task time 10.81.11.80.41.31.01.11.01.11.11.11.20.91.3
Vertical activity count, locomotor time 11.43.46.61.11.91.41.21.61.41.92.02.22.42.6
Time >=10cm from walls, locomotor time 20.20.40.70.60.60.80.80.80.80.40.40.4-0.0-0.2
Bouts of movement, locomotor time 20.20.31.21.10.10.1-0.3-0.0-0.2-0.4-0.3-0.2-0.7-0.8
Total resting periods, locomotor time 20.20.41.31.10.0-0.1-0.6-0.1-0.3-0.5-0.4-0.4-0.8-1.1
Rest time, locomotor task time 20.20.20.90.6-0.1-0.3-0.9-0.2-0.5-0.3-0.2-0.2-0.1-0.6
Distance moved, locomotor task time 20.10.10.5-0.70.50.00.20.10.20.20.20.30.40.6
Vertical activity count, locomotor time 20.30.41.4-0.30.80.10.10.30.30.40.50.61.21.1
Light reinforcement 10.10.20.7-0.8-0.0-0.6-0.7-0.4-0.4-0.3-0.1-0.00.60.5
Light reinforcement 20.50.81.30.11.10.90.80.91.00.80.80.90.90.9
Bone: marrow area3.37.28.7-2.9-2.8-2.8-2.2-2.8-2.7-2.8-2.9-2.8-2.3-2.4
Bone: maximum diameter0.91.65.4-2.3-1.0-1.4-1.8-1.2-1.1-1.0-1.0-1.0-0.2-0.3
Bone: maximum force2.03.55.3-2.1-1.7-2.2-2.3-2.1-2.0-2.0-1.7-1.6-1.3-1.0
Bone: maximum moment2.54.36.3-2.4-1.9-2.4-2.5-2.3-2.3-2.2-2.0-1.8-1.4-1.2
Mean time between licks in bursts0.41.12.10.51.00.81.10.90.80.81.21.21.31.4
Mean num. licks in bursts0.10.21.31.2-0.20.1-0.40.1-0.1-0.1-0.1-0.00.0-0.3
Cd content in liver1.11.22.0-0.4-1.0-1.1-0.7-1.2-1.2-0.9-1.1-1.3-1.4-1.2
Co content in liver0.50.51.0-0.2-0.8-0.8-0.6-0.9-0.9-0.5-0.7-0.7-1.0-0.6
Cu content in liver2.12.44.1-2.0-1.6-1.5-0.8-1.5-1.3-1.6-1.6-1.8-1.7-1.4
Fe content in liver0.50.63.4-1.8-0.7-0.7-0.2-0.7-0.4-0.7-0.7-0.7-0.7-0.3
K content in liver0.30.21.3-1.2-0.4-0.5-0.5-0.4-0.3-0.2-0.3-0.6-0.1-0.2
Mg content in liver0.10.10.9-1.0-0.1-0.00.30.00.20.1-0.0-0.2-0.1-0.1
Mn content in liver0.00.00.2-0.4-0.20.20.10.20.30.10.10.0-0.20.1
Na content in liver0.60.61.10.30.80.90.81.01.00.90.80.60.80.6
Rb content in liver3.33.94.9-2.2-2.2-1.9-1.5-1.9-1.8-1.9-2.0-2.1-2.1-1.8
Se content in liver2.12.54.2-0.81.41.31.71.51.71.41.61.61.92.1
Sr content in liver7.36.38.92.52.72.31.52.42.22.62.72.73.02.7
Zn content in liver0.30.42.0-0.40.40.61.40.60.80.40.30.20.10.1
Bone: minimum diameter3.25.910.8-2.6-2.0-2.7-3.3-2.5-2.6-2.3-2.4-2.4-1.6-1.8
Time in familiar zone, hab. session 12.42.44.3-1.5-1.4-2.1-1.2-1.9-2.0-1.7-1.4-1.4-0.9-0.6
Time in novel zone, hab. session 10.90.92.20.40.91.40.61.31.51.00.80.80.40.2
Total zone transitions, hab. session 12.12.93.8-1.8-1.8-1.9-1.9-1.8-1.9-1.7-1.7-1.8-1.0-1.1
Total locomotion distance, hab. session 10.20.30.7-0.1-0.5-0.8-0.6-0.7-0.8-0.4-0.4-0.50.0-0.1
Locomotion velocity, hab. session 10.10.20.50.3-0.5-0.5-0.3-0.5-0.7-0.3-0.3-0.5-0.1-0.3
Time in familiar zone, hab. session 21.61.62.8-0.8-1.2-1.2-0.4-1.3-1.2-1.6-1.4-1.4-1.7-1.4
Time in novel zone, hab. session 20.60.60.90.30.60.90.10.90.91.00.80.80.90.5
Total zone transitions, hab. session 22.43.15.0-2.0-1.8-2.2-2.2-2.0-2.0-1.4-1.5-1.7-0.6-0.8
Total locomotion distance, hab. session 20.10.20.60.60.2-0.1-0.3-0.0-0.20.40.30.20.80.4
Locomotion velocity, hab. session 20.20.21.00.60.3-0.1-0.30.1-0.10.50.40.31.00.7
Novel to familiar place preference ratio0.10.10.3-0.40.2-0.2-0.2-0.0-0.00.20.20.30.60.5
Novelty place preference0.10.10.4-0.6-0.1-0.4-0.5-0.3-0.3-0.1-0.1-0.00.20.2
Time in novel zone, NPP test0.10.10.4-0.6-0.2-0.5-0.4-0.4-0.4-0.2-0.2-0.10.10.1
Total zone transitions, NPP test0.10.20.5-0.5-0.4-0.6-0.7-0.5-0.6-0.3-0.2-0.30.20.2
Total locomotion distance, NPP test0.10.20.70.20.4-0.0-0.30.10.00.50.50.30.80.8
Locomotion velocity, NPP test0.10.20.60.00.3-0.2-0.5-0.0-0.10.40.40.20.80.7
Intraocular pressure0.10.20.50.1-0.4-0.1-0.5-0.2-0.2-0.4-0.4-0.4-0.5-0.7
Delta distance traveled before/after self-admin2.12.22.91.51.71.60.81.61.51.61.51.51.61.2
Delta ambulatory time before/after self-admin1.82.22.61.61.51.50.81.51.41.61.61.51.61.4
Parametrial fat weight2.66.27.32.52.42.52.42.52.42.72.72.42.42.4
Pavlov. Cond. lever latency0.10.20.70.80.20.2-0.70.10.00.0-0.1-0.1-0.4-0.6
Pavlov. Cond. magazine entry latency0.81.11.90.21.00.91.31.01.10.91.01.01.41.1
Pavlov. Cond. change in total contacts0.20.20.50.30.30.30.70.40.30.40.50.50.60.6
Pavlov. Cond. index score0.50.61.6-0.40.50.41.30.50.60.60.70.71.11.1
Pavlov. Cond. latency score0.50.61.8-0.10.50.41.30.60.60.60.80.71.11.1
Pavlov. Cond. lever contacts0.10.10.5-0.7-0.2-0.10.7-0.1-0.0-0.10.00.00.30.4
Pavlov. Cond. magazine entry number0.30.31.20.3-0.4-0.3-0.8-0.5-0.5-0.4-0.5-0.5-1.1-0.6
Pavlov. Cond. intertrial magazine entries0.20.31.60.0-0.2-0.5-1.2-0.5-0.6-0.4-0.4-0.4-0.4-0.2
Pavlov. Cond. lever-magazine prob. diff.0.50.61.5-0.40.50.41.20.50.60.60.70.71.11.1
Pavlov. Cond. response bias0.20.31.0-1.00.10.00.80.20.30.10.20.20.80.5
Pavlov. Cond. lever latency1.01.33.7-0.7-1.5-0.70.4-0.9-0.8-1.0-1.1-1.2-1.9-1.4
Pavlov. Cond. magazine entry latency1.61.93.11.11.71.30.31.41.31.41.41.51.81.5
Pavlov. Cond. change in total contacts0.20.32.50.20.2-0.4-1.6-0.2-0.4-0.2-0.1-0.10.40.1
Pavlov. Cond. index score0.50.61.80.51.10.5-0.60.70.50.60.70.81.30.9
Pavlov. Cond. latency score1.11.43.01.01.61.0-0.11.11.01.11.21.31.71.4
Pavlov. Cond. lever contacts0.60.82.60.31.20.4-0.80.60.50.70.80.91.61.1
Pavlov. Cond. magazine entry number0.70.91.6-1.2-1.3-1.0-0.3-1.0-0.9-0.8-0.9-1.0-1.1-0.8
Pavlov. Cond. intertrial magazine entries3.95.86.8-2.1-2.4-2.5-1.6-2.6-2.5-2.5-2.5-2.6-2.6-2.4
Pavlov. Cond. lever-magazine prob. diff.0.50.71.90.41.20.5-0.40.70.60.60.80.81.41.0
Pavlov. Cond. response bias0.20.31.7-0.20.5-0.2-1.3-0.0-0.1-0.00.10.20.90.4
Time in closed arm before self-admin0.20.21.1-0.5-1.0-0.30.4-0.5-0.3-0.1-0.10.00.10.6
Time in closed arm after self-admin0.10.10.20.2-0.4-0.0-0.1-0.2-0.1-0.2-0.3-0.2-0.4-0.4
Time in open arm before self-admin0.50.62.60.91.60.7-0.40.90.70.60.60.50.4-0.1
Time in open arm after self-admin0.00.00.40.10.60.1-0.10.20.10.10.20.00.0-0.0
Bone: periosteal estimation2.65.47.3-2.7-2.2-2.6-2.7-2.4-2.4-2.4-2.4-2.3-1.6-1.8
Bone: periosteal perimeter2.84.87.3-2.2-1.7-2.3-2.7-2.1-2.2-2.3-2.3-2.3-1.7-2.1
Bone: post-yield work3.04.35.3-1.6-2.2-1.9-2.2-2.0-1.9-2.2-2.2-2.0-2.3-2.3
Progressive ratio test 1 active lever presses0.60.82.0-1.4-1.0-1.1-0.8-1.0-1.0-0.8-0.7-0.7-0.3-0.1
Progressive ratio test 1 breakpoint0.60.71.7-1.3-1.0-1.0-0.8-0.9-0.9-0.8-0.7-0.7-0.3-0.1
Progressive ratio test 1 inactive lever presses1.72.55.6-2.3-2.4-1.6-0.5-1.7-1.5-1.6-1.5-1.4-1.2-0.7
Progressive ratio test 2 active lever presses0.20.31.5-1.2-1.0-0.10.7-0.30.1-0.1-0.1-0.2-0.20.4
Progressive ratio test 2 breakpoint0.30.41.8-1.4-1.1-0.20.6-0.4-0.0-0.2-0.3-0.3-0.30.2
Progressive ratio test 2 inactive lever presses1.72.86.5-2.6-2.6-1.7-0.6-1.8-1.6-1.5-1.5-1.5-1.2-0.6
Incentive Sensitization - Responses0.40.52.1-1.3-1.4-0.30.2-0.6-0.2-0.4-0.5-0.5-0.9-0.1
Incentive Sensitization - Breakpoint0.30.41.5-1.2-1.2-0.10.4-0.4-0.0-0.2-0.3-0.3-0.70.0
Sum of active levers in priming session hrs 5-60.50.51.00.90.50.50.50.40.40.80.80.80.61.0
Progressive ratio0.10.10.50.20.1-0.2-0.7-0.1-0.20.10.20.10.50.4
Food seeking constrained by brief footshock1.41.74.90.90.8-0.9-2.0-0.4-1.00.60.90.92.22.1
Seeking ratio, punishment vs. effort0.20.30.8-0.1-0.4-0.8-0.7-0.7-0.9-0.3-0.3-0.20.00.2
Retroperitoneal fat weight4.418.624.04.44.54.94.94.74.74.34.24.23.22.9
Reaction time number correct0.30.52.3-0.50.90.10.40.40.30.50.60.61.51.1
Reaction time mean minus median0.10.10.40.5-0.30.10.50.00.0-0.1-0.3-0.4-0.5-0.6
Reaction time mean minus median AUC0.10.20.80.1-0.0-0.00.3-0.1-0.1-0.3-0.5-0.6-0.7-0.9
Reaction time num false alarms0.50.73.1-1.8-0.1-0.10.70.10.30.30.50.41.01.5
Reaction time num false alarms AUC0.50.82.7-1.40.30.10.70.30.50.60.70.71.31.7
Reaction time trials correct on left0.30.52.3-0.50.90.10.40.40.30.50.60.61.51.1
Reaction time trials on left0.30.52.3-0.50.90.10.40.40.30.50.60.61.51.1
Reaction time mean0.61.02.8-0.1-1.7-0.30.4-0.7-0.6-0.7-1.1-1.0-1.5-1.3
Reaction time mean AUC0.30.51.50.3-1.20.10.9-0.2-0.1-0.3-0.7-0.5-1.1-1.0
Median of all reaction times0.60.92.8-0.1-1.7-0.30.4-0.6-0.5-0.7-1.0-0.9-1.5-1.2
Reaction time omissions0.00.10.20.3-0.10.10.10.10.10.30.20.30.40.5
Reaction time false alarm rate0.20.21.0-0.7-0.20.20.50.20.30.40.40.40.41.0
Reaction time premature initiation rate0.30.31.81.40.10.60.40.40.30.70.50.60.10.2
Reaction time premature initiations0.40.71.41.20.70.70.60.70.61.00.80.90.90.7
Std. dev. reaction times0.20.41.10.2-1.1-0.10.7-0.3-0.3-0.3-0.6-0.6-0.9-0.7
Reaction time trials completed0.30.52.3-0.50.90.10.40.40.30.50.60.61.51.1
Reaction time trials AUC0.30.62.4-0.60.90.10.50.40.40.50.60.61.61.1
Run reversals in cocaine runway, females0.30.31.51.2-0.10.70.10.30.40.40.20.2-0.7-0.2
Run reversals in cocaine runway, males0.30.30.6-0.8-0.2-0.4-0.3-0.4-0.3-0.7-0.6-0.6-0.7-0.7
Latency to leave start box in cocaine runway0.10.11.10.4-0.2-0.2-0.2-0.4-0.30.0-0.1-0.1-1.00.1
Latency to leave start box in cocaine runway, F0.20.20.70.90.50.3-0.10.20.30.50.50.6-0.40.7
Latency to leave start box in cocaine runway, M1.51.42.8-1.0-1.1-1.2-0.6-1.3-1.1-1.1-1.2-1.3-1.7-1.2
Std. dev. time between licks in bursts0.10.20.6-0.70.5-0.30.1-0.2-0.2-0.10.30.10.70.8
Total sessions with >9 infusions1.51.94.4-2.1-1.5-1.5-1.0-1.4-1.3-1.4-1.4-1.4-0.9-0.9
Short access day 1 total inactive lever presses0.81.02.9-1.7-1.4-0.80.0-0.9-0.6-0.9-1.0-1.0-1.0-0.8
Short access day 10 total inactive lever presses0.00.10.60.2-0.8-0.10.3-0.3-0.3-0.1-0.1-0.2-0.5-0.1
Short access day 1 total infusions0.20.31.0-1.0-0.3-0.4-0.2-0.4-0.3-0.5-0.5-0.5-0.4-0.5
Short access day 10 total infusions0.20.21.5-1.2-0.2-0.10.50.00.20.00.00.00.50.5
Short access total infusions0.10.10.8-0.90.0-0.00.40.10.2-0.00.0-0.00.40.2
Short access day 1 locomotion1.11.32.9-1.7-1.3-0.9-0.6-0.9-0.7-1.1-1.2-1.3-1.2-1.2
Short access day 10 total locomotion0.40.72.1-0.3-1.4-0.9-0.6-1.1-1.1-0.7-0.7-0.6-0.5-0.2
Short access total locomotion0.30.40.7-0.7-0.9-0.8-0.5-0.7-0.8-0.4-0.4-0.40.30.2
One hour access (0.3 mA shock)2.02.37.7-1.7-2.8-1.3-0.6-1.6-1.3-1.5-1.5-1.3-1.5-0.7
Compulsive drug intake1.51.83.1-1.3-1.8-1.3-1.0-1.4-1.3-1.4-1.4-1.2-1.6-1.0
One hour access (shock baseline)0.10.20.8-0.7-0.90.20.9-0.00.2-0.0-0.1-0.1-0.10.2
Social response proportion0.40.51.2-0.9-0.9-0.40.9-0.7-0.4-0.4-0.5-0.4-1.1-0.3
Social responses2.63.35.4-2.3-2.1-1.8-0.5-2.0-1.7-1.9-1.8-1.8-2.0-1.4
Social time2.23.05.1-1.6-1.8-2.3-1.5-2.2-2.3-1.7-1.6-1.6-1.1-0.8
Soleus weight0.10.20.7-0.60.3-0.10.00.00.10.00.30.40.70.8
Bone: stiffness2.23.67.9-2.8-2.1-2.2-1.9-2.1-1.9-1.9-1.7-1.6-1.3-0.9
Tibialis anterior weight1.24.09.5-0.32.11.51.61.81.91.61.92.23.12.6
Time to tail flick, vehicle, before self-admin0.10.10.7-0.3-0.3-0.3-0.4-0.2-0.20.20.20.30.20.8
Time to tail flick, vehicle, after self-admin0.50.72.2-0.3-1.0-0.30.0-0.5-0.4-0.7-0.8-0.9-1.5-1.3
Time to tail flick, test, before self-admin0.30.31.00.80.4-0.4-1.0-0.3-0.60.20.30.40.70.7
Time to tail flick, test, after self-admin0.20.20.40.60.50.60.10.50.50.50.40.4-0.00.2
Delta time to tail flick, vehicle, before/after SA0.40.41.8-0.0-0.4-0.10.2-0.2-0.1-0.5-0.6-0.8-1.0-1.3
Delta time to tail flick, test, before/after SA0.20.20.7-0.4-0.30.40.50.20.4-0.1-0.2-0.3-0.8-0.6
Tibia length3.28.917.8-4.2-2.9-3.4-3.1-3.2-3.1-2.9-2.8-2.9-2.0-1.7
Ambulatory time before self-admin1.11.63.2-1.2-1.0-1.8-1.7-1.6-1.8-1.1-1.0-1.0-0.3-0.1
Ambulatory time after self-admin0.40.51.40.50.3-0.4-1.1-0.2-0.50.40.50.41.21.1
Bone: tissue strength0.40.41.50.60.4-0.1-0.30.0-0.10.50.70.80.91.2
Total heroin consumption0.10.10.30.20.40.2-0.00.30.30.40.40.30.60.5
Bone: trabecular number0.00.10.20.00.3-0.1-0.40.1-0.0-0.3-0.2-0.10.4-0.3
Bone: trabecular spacing0.00.00.10.20.40.0-0.10.00.00.20.10.10.00.2
Bone: trabecular thickness0.00.00.3-0.5-0.1-0.10.2-0.00.1-0.1-0.1-0.2-0.2-0.2
Bone: trabecular tissue density1.01.53.20.90.91.51.81.31.51.31.21.20.30.9
Water consumed over 24 hours0.50.72.0-0.1-0.7-1.0-1.4-1.0-1.1-0.9-0.8-0.5-0.5-0.5
Number of responses in last shaping day0.30.31.4-1.0-0.30.11.2-0.00.3-0.2-0.3-0.3-0.4-0.3