LOC103694298

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	BLA	gene expression	LOC103694298	0.19	0.09	7.1e-07	0.09	0.09	0.08	0.09	1.3e-05	1.8e-05	5.6e-05	1.6e-05
2	PL	gene expression	LOC103694298	0.11	0.06	1.8e-08	0.06	0.06	0.06	0.06	2.0e-07	2.6e-07	3.3e-07	3.4e-07
3	pVTA	gene expression	LOC103694298	0.34	0.14	1.8e-11	0.14	0.14	0.12	0.14	1.0e-11	4.5e-11	3.1e-10	2.9e-11
4	NAcc	gene expression	LOC103694298	0.11	0.06	7.6e-10	0.06	0.06	0.06	0.06	2.2e-09	2.7e-09	3.0e-09	1.6e-09
5	Brain	gene expression	LOC103694298	0.04	0.03	8.2e-04	0.04	0.03	0.03	0.03	1.6e-04	1.6e-03	2.1e-03	4.3e-04
6	IC	gene expression	LOC103694298	0.16	0.17	1.9e-03	0	0.02	0.01	0	2.8e-01	3.4e-02	1.7e-01	2.7e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	2.5	4.6	6.8	2.6	2.6	2.1	-2.3	1.3	-1.7
Area under the delay curve	0.5	0.8	1.0	-0.9	-0.9	-0.7	0.9	-1.0	0.9
BMI with tail	2.5	8.9	10.6	-3.1	-3.0	-3.3	3.1	-2.8	2.6
BMI without tail	0.3	1.5	2.1	-1.0	-0.9	-1.3	1.4	-1.3	1.3
Body weight	0.7	3.1	4.6	-2.1	-2.1	-1.9	2.0	-1.2	0.9
Weight adjusted by age	1.2	3.4	4.6	-1.9	-2.1	-2.1	1.7	-1.9	1.2
Bone surface	0.7	1.5	2.4	1.5	1.5	1.1	-1.3	0.7	-0.8
Bone volume	2.0	3.9	5.3	2.3	2.3	1.9	-2.1	1.7	-1.5
Breakpoint value in progressive ratio session	0.6	1.1	1.5	1.1	1.2	1.1	-1.1	0.9	-0.9
Number of licking bursts	0.2	0.5	0.6	0.7	0.6	0.8	-0.7	0.8	-0.8
Context. condit. distance diff. score	2.4	3.0	4.1	-1.9	-1.7	-1.7	1.2	-2.0	1.7
Locomotion velocity, session 1	0.0	0.0	0.0	-0.0	-0.1	-0.2	0.2	0.2	-0.1
Locomotion distance, session 1	0.0	0.0	0.0	0.1	-0.0	-0.1	0.0	-0.1	-0.0
Locomotion velocity, session 2	0.0	0.0	0.1	-0.1	-0.2	-0.0	-0.1	-0.3	0.2
Locomotion distance, session 2	0.1	0.2	0.3	-0.3	-0.4	-0.4	0.5	-0.5	-0.1
Locomotion velocity, session 3	2.9	3.3	3.9	-1.9	-1.9	-2.0	1.7	-1.7	1.7
Locomotion distance, session 3	0.8	0.9	1.9	-1.0	-1.0	-0.9	0.8	-0.5	1.4
Stereotopy head waving bouts, day 3	1.5	1.8	2.5	-1.2	-1.3	-1.4	1.6	-1.2	1.4
Stereotopy head waving duration, day 3	1.6	2.0	2.8	-1.3	-1.3	-1.4	1.7	-1.5	1.2
Locomotion velocity, session 7	0.3	0.4	1.2	-0.4	-0.4	-0.6	0.2	-1.1	0.6
Locomotion distance, session 7	1.3	1.6	2.2	1.4	1.3	1.4	-1.5	0.6	-1.3
Stereotopy head waving bouts, day 7	3.6	4.2	5.6	-2.0	-2.0	-2.1	2.3	-1.3	2.4
Stereotopy head waving duration, day 7	1.0	1.2	2.4	-0.9	-1.0	-1.1	1.4	-0.3	1.6
Locomotion velocity, session 8	0.3	0.4	1.5	-0.5	-0.5	-0.6	0.3	-1.2	0.1
Locomotion distance, session 8	0.8	1.2	2.1	-1.2	-1.1	-1.2	0.8	-1.5	0.8
Degree of sensitization distance	1.7	1.8	3.3	1.4	1.4	1.4	-1.3	0.4	-1.8
Degree of sensitization stereotypy	3.1	3.4	5.0	-1.8	-1.8	-1.9	2.0	-1.2	2.2
Conditioned locomotion	0.3	0.4	0.5	0.5	0.6	0.7	-0.7	0.5	-0.7
Cocaine response after cond. corrected	0.4	0.6	1.3	-0.8	-0.7	-0.6	0.8	-1.2	0.4
Cocaine response after cond. not corrected	0.4	0.6	1.0	-0.9	-0.8	-0.7	0.9	-1.0	0.4
Cocaine response before conditioning	0.4	0.4	1.4	0.6	0.5	0.3	-0.5	1.2	-0.5
Saline control response	3.1	4.2	5.7	2.4	2.4	1.9	-2.0	1.0	-2.4
Bone: connectivity density	3.2	5.1	7.6	2.8	2.7	2.3	-2.4	1.1	-1.9
Bone: cortical apparent density	0.1	0.2	0.8	0.4	0.4	0.2	-0.2	-0.3	0.9
Bone: cortical area	0.1	0.2	0.3	0.4	0.5	0.4	-0.4	0.5	-0.4
Bone: cortical porosity	0.3	0.4	0.5	-0.7	-0.7	-0.7	0.7	-0.1	0.3
Bone: cortical porosity	0.1	0.1	0.2	-0.4	-0.4	-0.5	0.5	0.1	0.3
Bone: cortical thickness	0.0	0.1	0.1	0.3	0.4	0.2	-0.2	0.3	-0.1
Bone: cortical thickness	0.1	0.1	0.7	0.3	0.1	-0.2	0.1	-0.8	-0.1
Bone: cortical tissue density	0.1	0.2	0.9	0.3	0.3	0.2	-0.1	-0.4	1.0
Condit. Reinf. active minus inactive responses	1.5	1.8	4.8	-1.0	-1.0	-1.1	1.2	-1.1	2.2
Condit. Reinf. active-inactive response ratio	1.9	2.0	2.7	-1.3	-1.4	-1.3	1.4	-1.3	1.6
Condit. Reinf. active responses	0.3	0.4	2.3	-0.1	-0.2	-0.3	0.5	-0.2	1.5
Condit. Reinf. inactive responses	2.3	2.9	3.8	1.9	1.9	1.8	-1.7	1.8	-0.9
Incentive salience index mean	0.3	0.3	1.7	0.3	0.2	0.2	-0.1	0.3	1.3
Condit. Reinf. lever presses	0.8	1.3	2.0	1.1	1.1	1.2	-1.2	1.4	0.3
Condit. Reinf. active minus inactive responses	0.1	0.2	0.3	-0.5	-0.4	-0.3	0.5	-0.2	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.4	-0.6	-0.5	-0.4	0.6	-0.2	0.1
Condit. Reinf. active responses	0.2	0.3	0.5	-0.6	-0.6	-0.6	0.7	-0.4	0.5
Condit. Reinf. inactive responses	0.4	0.6	1.0	-0.7	-0.8	-1.0	0.8	-0.9	0.7
Condit. Reinf. lever presses	0.6	0.9	1.2	-1.1	-1.0	-0.9	0.9	-1.0	0.9
Condit. Reinf. lever reinforcers received	0.7	0.9	1.1	-1.0	-1.0	-1.0	1.0	-0.8	0.9
Conditioned reinforcement - actives	0.0	0.2	0.9	0.2	0.1	0.2	-0.1	0.2	-0.9
Conditioned reinforcement - inactives	0.2	0.6	0.9	-0.9	-1.0	-0.9	0.8	-0.6	0.5
Conditioned locomotion	0.1	0.1	0.2	0.2	0.2	0.3	-0.4	0.2	-0.3
Patch foraging indifference point 0 sec	0.7	2.1	2.6	-1.5	-1.5	-1.5	1.4	-1.6	1.1
Patch foraging indifference point AUC	1.0	2.3	2.9	1.5	1.7	1.6	-1.2	1.7	-1.4
Delay disc. indifference point, 0s delay	0.6	0.6	1.2	0.7	0.7	0.7	-0.5	0.8	-1.1
Delay disc. indifference point, 16s delay	0.7	1.0	1.3	-1.1	-1.1	-0.9	1.0	-1.0	0.8
Delay disc. indifference point, 2s delay	0.8	0.9	1.4	-0.9	-0.9	-0.8	1.0	-1.2	0.9
Delay disc. indifference point, 24s delay	0.1	0.1	0.2	-0.3	-0.3	-0.2	0.4	-0.3	0.4
Delay disc. indifference point, 4s delay	0.0	0.0	0.1	0.0	0.0	0.1	-0.0	-0.4	0.1
Delay disc. indifference point, 8s delay	1.2	2.0	2.3	-1.5	-1.5	-1.3	1.4	-1.4	1.3
Indifference point function ln k	0.9	2.8	4.1	-1.5	-1.6	-1.6	1.3	-2.0	1.8
Indifference point function log k	0.9	2.8	4.1	-1.5	-1.6	-1.6	1.3	-2.0	1.8
Patch foraging total patch changes 0 sec	0.9	2.7	3.3	-1.7	-1.7	-1.8	1.6	-1.8	1.2
Patch foraging total patch changes 12 sec	0.6	0.8	1.2	1.0	1.1	0.9	-0.8	0.8	-0.8
Patch foraging total patch changes 18 sec	1.1	2.7	3.5	1.9	1.9	1.6	-1.3	1.5	-1.7
Patch foraging total patch changes 24 sec	0.1	0.3	0.5	0.6	0.6	0.4	-0.5	0.7	-0.7
Patch foraging total patch changes 6 sec	0.0	0.1	0.2	0.0	0.1	-0.0	0.1	0.4	-0.4
Patch foraging time to switch 0 sec	0.0	0.1	0.1	-0.1	-0.3	-0.3	-0.0	0.3	0.2
Patch foraging water rate 0 sec	0.1	0.2	0.6	0.5	0.6	0.4	-0.1	0.1	-0.8
Patch foraging water rate 12 sec	0.2	0.8	1.3	0.8	0.9	1.0	-1.2	0.8	-0.5
Patch foraging water rate 18 sec	0.7	1.7	2.6	1.2	1.3	1.2	-1.4	1.6	-0.9
Patch foraging water rate 24 sec	0.0	0.1	0.1	0.3	0.2	0.1	-0.3	0.2	0.3
Patch foraging water rate 6 sec	3.5	5.2	6.3	2.5	2.5	2.3	-2.4	1.8	-2.2
Seeking ratio, delayed vs. immediate footshock	4.6	6.5	7.4	-2.6	-2.5	-2.5	2.5	-2.7	2.4
Distance traveled before self-admin	2.0	4.3	5.4	-2.2	-2.0	-2.0	2.1	-1.8	2.3
Distance traveled after self-admin	0.2	0.3	0.4	-0.6	-0.4	-0.5	0.6	0.0	0.7
Extensor digitorum longus weight	0.1	0.4	0.7	0.3	0.3	0.4	-0.6	0.9	-0.8
Bone: elastic displacement	0.3	0.4	0.7	0.5	0.6	0.8	-0.6	0.3	-0.6
Bone: elastic work	0.1	0.2	0.3	0.3	0.4	0.6	-0.5	0.2	-0.5
Bone: endosteal estimation	0.0	0.0	0.1	-0.3	-0.2	-0.1	-0.1	-0.1	-0.1
Bone: endosteal perimeter	0.1	0.2	0.4	-0.6	-0.5	-0.3	0.2	-0.6	0.3
Epididymis fat weight	0.3	1.5	1.9	-1.3	-1.3	-1.3	1.4	-0.9	1.1
Delta time in closed arm before/after self-admin	0.7	0.6	1.1	-0.7	-0.6	-0.7	1.1	-0.9	0.7
Delta time in open arm before/after self-admin	1.1	1.3	1.8	1.0	1.0	1.1	-1.2	1.2	-1.3
Diff in mean of infusions in LGA sessions	0.2	0.4	0.7	0.6	0.8	0.6	-0.5	0.4	-0.7
Delay discount exponential model param	0.5	0.7	0.9	0.8	0.8	0.6	-0.8	1.0	-0.9
Extinction: sum of active levers before priming	2.6	4.0	5.0	-1.9	-1.8	-2.0	1.9	-2.1	2.2
Active lever presses in extinction session 6	0.0	0.0	0.2	-0.0	0.1	-0.0	-0.2	-0.1	0.5
Bone: final force	0.5	0.9	1.5	0.9	0.9	0.7	-0.7	1.2	-1.0
Bone: final moment	0.2	0.4	0.9	0.6	0.6	0.4	-0.4	0.9	-0.7
Food consumed during 24 hour testing period	3.9	7.8	9.2	3.0	2.9	2.8	-2.7	2.5	-2.7
Glucose	0.1	0.2	0.7	0.2	0.3	-0.0	-0.2	0.3	-0.8
Heart weight	0.9	1.4	1.7	-1.3	-1.2	-0.9	1.1	-1.3	1.2
Delay discount hyperbolic model param	0.5	0.7	0.9	0.7	0.7	0.6	-0.8	0.9	-1.0
Intermittent access intake day 1-15 change	0.9	5.1	5.7	2.3	2.2	2.1	-2.2	2.4	-2.2
Intermittent access intake escalation	0.7	3.7	4.2	2.0	1.9	1.8	-1.9	2.0	-1.9
Intermittent access intake escalation 2	1.6	2.6	3.4	1.5	1.5	1.5	-1.6	1.7	-1.9
Intermitt. access day 1 inactive lever presses	0.0	0.3	1.3	-0.2	-0.1	-0.4	0.3	-0.5	1.2
Intermitt. access day 15 inactive lever presses	0.2	1.3	2.9	-1.0	-0.9	-1.0	0.9	-1.0	1.7
Intermitt. access escalation Index	0.2	0.6	1.5	-0.6	-0.6	-0.5	0.5	-0.8	1.2
Intermittent access day 1 total infusions	0.5	1.6	2.0	-1.4	-1.4	-1.3	1.3	-0.9	1.3
Intermittent access day 15 total infusions	0.0	0.0	0.1	-0.0	-0.1	-0.1	0.0	0.2	-0.3
Intermittent access terminal intake (last 3 days)	0.0	0.1	0.2	-0.3	-0.4	-0.2	0.3	-0.1	-0.2
Intermittent access total infusions	0.0	0.0	0.1	-0.1	-0.1	-0.0	0.1	0.3	-0.2
Intermittent access day 1 locomotion	0.0	0.0	0.2	-0.1	-0.2	0.0	-0.0	0.2	0.4
Intermittent access day 15 total locomotion	0.0	0.1	0.2	-0.4	-0.4	-0.4	0.1	0.1	0.0
Intermittent access total locomotion	0.0	0.1	0.1	-0.3	-0.3	-0.2	0.2	0.2	0.0
Intermittent access standard deviation	0.3	1.4	2.0	1.2	1.1	1.1	-1.3	1.4	-0.8
Left kidney weight	0.5	4.3	5.4	2.0	2.1	2.0	-1.9	2.2	-2.3
Right kidney weight	0.1	0.4	1.1	0.3	0.4	0.3	-0.2	1.1	-1.0
Cocaine induced anxiety	0.4	1.1	1.4	-1.0	-1.0	-1.0	1.2	-1.2	0.8
Post-drug Anxiety	0.6	0.7	0.9	-0.7	-0.7	-0.7	0.9	-1.0	0.8
Baseline Anxiety	0.3	0.5	0.6	0.7	0.7	0.7	-0.8	0.8	-0.4
Tail length	0.6	3.1	3.5	1.9	1.9	1.9	-1.6	1.6	-1.7
Length with tail	0.1	0.5	1.2	0.3	0.3	0.6	-0.4	1.1	-1.1
Length without tail	0.2	0.9	1.7	-1.3	-1.3	-1.0	1.1	-0.3	0.1
Times rat made contact with spout	0.0	0.0	0.1	0.3	0.2	0.1	-0.2	0.0	-0.0
Lifetime Intake	0.0	0.0	0.1	0.0	0.0	0.1	-0.1	0.4	-0.4
Liver weight, left	0.0	0.1	0.2	-0.1	0.2	-0.2	0.5	0.0	-0.3
Liver weight, right	0.2	0.3	0.7	-0.5	-0.5	-0.6	0.8	0.0	-0.1
Locomotor activity	0.3	0.5	0.8	-0.9	-0.8	-0.9	0.7	-0.7	-0.1
Locomotor testing distance	0.2	0.4	0.7	-0.8	-0.7	-0.7	0.4	-0.6	-0.1
Locomotor testing rearing	0.1	0.5	1.4	0.6	0.7	0.4	-0.6	0.6	-1.2
Locomotion in novel chamber	0.9	1.2	1.5	-1.2	-1.2	-1.2	1.2	-0.6	1.0
Locomotion in novel chamber post-restriction	0.2	0.7	1.6	0.8	0.8	0.8	-0.8	1.3	-0.4
Fecal boli incidents, locomotor time 1	0.7	1.7	2.3	1.1	1.2	1.4	-1.5	1.1	-1.5
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.2	0.1	-0.2	0.3	-0.2	0.4
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.5	-0.1	-0.1	-0.1	-0.2	0.7	-0.1
Bouts of movement, locomotor time 1	1.3	1.7	2.4	1.5	1.5	1.3	-1.5	0.7	-1.0
Total resting periods, locomotor time 1	1.0	1.2	1.8	1.3	1.3	1.2	-1.3	0.5	-0.7
Rest time, locomotor task time 1	0.7	1.2	1.7	1.2	1.1	1.1	-1.3	0.8	-1.0
Distance moved, locomotor task time 1	0.2	0.6	0.9	-0.8	-0.8	-0.8	0.7	-0.8	0.9
Vertical activity count, locomotor time 1	0.0	0.2	0.6	0.3	0.5	0.4	-0.3	0.8	-0.5
Time >=10cm from walls, locomotor time 2	0.2	0.6	0.9	-0.9	-0.8	-1.0	0.8	-0.6	0.5
Bouts of movement, locomotor time 2	0.0	0.1	0.3	0.1	0.1	0.1	-0.0	-0.5	0.5
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.5	0.4	0.4	-0.3	-0.3	0.2
Rest time, locomotor task time 2	1.1	1.8	2.4	1.5	1.5	1.5	-1.5	0.3	-1.2
Distance moved, locomotor task time 2	2.7	3.6	5.3	-2.0	-2.1	-2.3	2.0	-1.2	1.7
Vertical activity count, locomotor time 2	0.1	0.3	0.5	-0.5	-0.4	-0.6	0.7	0.3	-0.2
Light reinforcement 1	5.6	25.5	29.0	5.1	5.0	5.1	-4.9	5.4	-4.9
Light reinforcement 2	6.9	15.5	17.6	3.8	3.8	4.2	-4.1	3.9	-3.8
Bone: marrow area	0.0	0.1	0.2	-0.4	-0.3	-0.2	0.0	-0.2	-0.0
Bone: maximum diameter	0.4	0.8	1.1	-1.0	-0.9	-0.8	0.9	-0.7	0.9
Bone: maximum force	0.1	0.3	0.4	0.6	0.6	0.4	-0.4	0.4	-0.7
Bone: maximum moment	0.0	0.1	0.2	0.3	0.3	0.1	-0.2	0.2	-0.4
Mean time between licks in bursts	0.1	0.8	2.1	-1.1	-1.0	-0.8	0.5	-0.2	1.4
Mean num. licks in bursts	0.1	0.3	0.6	-0.3	-0.2	-0.5	0.5	-0.7	0.8
Cd content in liver	0.5	0.6	1.8	-0.7	-0.5	-0.4	0.4	-1.3	0.9
Co content in liver	1.4	1.7	2.9	-1.4	-1.4	-1.1	0.8	-1.1	1.7
Cu content in liver	0.1	0.1	0.1	-0.3	-0.2	-0.4	0.2	0.1	0.2
Fe content in liver	0.8	1.0	2.0	1.0	0.9	0.8	-0.9	1.4	-0.6
K content in liver	1.1	1.1	1.5	-1.2	-1.2	-1.1	1.0	-0.5	0.9
Mg content in liver	1.0	1.1	1.4	-1.1	-1.2	-1.2	1.2	-0.8	0.8
Mn content in liver	0.2	0.2	0.7	-0.3	-0.4	-0.3	0.2	-0.8	0.3
Na content in liver	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.1	0.3	0.2
Rb content in liver	0.3	0.3	0.6	0.7	0.6	0.2	-0.3	0.6	-0.7
Se content in liver	0.9	1.1	2.2	1.0	0.7	1.0	-1.1	1.5	-0.7
Sr content in liver	0.5	0.5	0.8	-0.9	-0.7	-0.8	0.6	-0.4	0.7
Zn content in liver	2.2	2.5	3.7	-1.5	-1.5	-1.7	1.5	-1.9	1.3
Bone: minimum diameter	1.0	2.0	2.3	1.3	1.5	1.4	-1.5	1.5	-1.3
Time in familiar zone, hab. session 1	0.4	0.4	0.9	0.5	0.5	0.6	-0.7	1.0	0.2
Time in novel zone, hab. session 1	0.1	0.2	0.4	-0.3	-0.4	-0.3	0.4	-0.7	-0.1
Total zone transitions, hab. session 1	0.2	0.3	0.4	-0.6	-0.6	-0.6	0.7	-0.4	0.2
Total locomotion distance, hab. session 1	0.2	0.3	0.6	-0.4	-0.5	-0.5	0.5	-0.8	0.1
Locomotion velocity, hab. session 1	0.2	0.3	0.7	-0.5	-0.4	-0.5	0.6	-0.8	0.1
Time in familiar zone, hab. session 2	1.4	1.6	2.4	1.3	1.3	1.5	-1.4	1.1	-0.9
Time in novel zone, hab. session 2	2.4	2.6	3.4	-1.6	-1.6	-1.8	1.7	-1.7	1.2
Total zone transitions, hab. session 2	0.0	0.0	0.1	0.1	0.0	-0.3	0.2	-0.3	0.1
Total locomotion distance, hab. session 2	0.1	0.1	0.2	0.0	0.0	-0.2	0.3	-0.4	-0.3
Locomotion velocity, hab. session 2	0.1	0.1	0.4	0.3	0.2	0.0	0.1	-0.2	-0.6
Novel to familiar place preference ratio	0.8	1.0	1.5	-0.9	-0.8	-1.0	1.0	-1.2	1.0
Novelty place preference	0.5	0.6	1.1	-0.6	-0.6	-0.8	0.8	-1.0	0.6
Time in novel zone, NPP test	0.7	0.8	1.1	-0.8	-0.8	-0.9	0.9	-1.1	0.9
Total zone transitions, NPP test	0.1	0.2	0.3	-0.3	-0.4	-0.5	0.6	-0.1	0.2
Total locomotion distance, NPP test	0.2	0.3	0.4	-0.4	-0.5	-0.6	0.7	-0.5	0.4
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.0	-0.2	-0.3	0.3	-0.2	-0.1
Intraocular pressure	3.0	5.0	7.5	-2.2	-2.1	-2.0	2.0	-2.7	2.2
Delta distance traveled before/after self-admin	2.5	2.8	3.6	1.6	1.6	1.6	-1.6	1.9	-1.7
Delta ambulatory time before/after self-admin	2.5	4.2	5.6	2.0	2.0	2.0	-2.0	2.4	-1.9
Parametrial fat weight	0.0	0.1	0.4	-0.0	-0.1	-0.0	0.2	-0.0	-0.7
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.1	0.2	0.3	-0.4	0.1	-0.6
Pavlov. Cond. magazine entry latency	0.1	0.1	0.3	-0.2	-0.3	-0.2	0.2	0.0	0.5
Pavlov. Cond. change in total contacts	0.2	0.2	0.5	0.6	0.5	0.4	-0.1	0.7	0.1
Pavlov. Cond. index score	0.3	0.4	1.0	-0.5	-0.6	-0.6	0.7	-0.3	1.0
Pavlov. Cond. latency score	0.2	0.2	0.6	-0.3	-0.4	-0.4	0.5	-0.2	0.8
Pavlov. Cond. lever contacts	0.3	0.3	0.7	-0.4	-0.5	-0.6	0.6	-0.3	0.9
Pavlov. Cond. magazine entry number	0.5	0.7	1.1	0.8	0.9	0.9	-0.8	0.2	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.1	-0.3	-0.2	-0.3	0.3	-0.4	0.4
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	1.1	-0.7	-0.8	-0.8	0.8	-0.4	1.1
Pavlov. Cond. response bias	0.5	0.7	1.6	-0.7	-0.7	-0.8	0.8	-0.2	1.3
Pavlov. Cond. lever latency	0.1	0.1	0.4	0.1	0.0	0.0	0.3	-0.7	-0.2
Pavlov. Cond. magazine entry latency	0.1	0.1	0.1	-0.4	-0.3	-0.3	0.1	0.3	0.3
Pavlov. Cond. change in total contacts	0.2	0.4	0.6	-0.7	-0.7	-0.7	0.6	0.0	0.8
Pavlov. Cond. index score	0.1	0.2	0.3	-0.6	-0.5	-0.6	0.3	0.2	0.6
Pavlov. Cond. latency score	0.1	0.1	0.2	-0.4	-0.3	-0.4	0.1	0.4	0.4
Pavlov. Cond. lever contacts	0.1	0.2	0.8	0.1	0.2	0.2	-0.5	0.9	-0.0
Pavlov. Cond. magazine entry number	0.1	0.2	0.3	0.6	0.5	0.5	-0.2	-0.1	-0.4
Pavlov. Cond. intertrial magazine entries	0.6	1.3	1.8	1.3	1.3	1.2	-0.8	0.7	-1.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	0.4	-0.6	-0.5	-0.6	0.4	0.2	0.7
Pavlov. Cond. response bias	0.1	0.2	0.3	-0.5	-0.4	-0.5	0.1	0.4	0.4
Time in closed arm before self-admin	1.4	2.5	3.5	1.7	1.5	1.7	-1.7	1.9	-0.8
Time in closed arm after self-admin	0.7	0.8	1.1	1.0	1.0	1.1	-0.9	0.8	-0.3
Time in open arm before self-admin	1.6	2.0	2.7	-1.5	-1.4	-1.5	1.6	-1.2	1.0
Time in open arm after self-admin	1.0	1.1	1.4	-1.2	-1.2	-1.2	1.2	-0.7	0.5
Bone: periosteal estimation	0.1	0.1	0.2	0.2	0.3	0.4	-0.4	0.4	-0.4
Bone: periosteal perimeter	0.1	0.2	0.4	-0.5	-0.3	-0.3	0.3	-0.6	0.4
Bone: post-yield work	0.1	0.2	0.8	-0.1	-0.2	-0.3	0.1	-0.9	0.2
Progressive ratio test 1 active lever presses	0.0	0.1	0.3	-0.1	-0.2	-0.1	0.1	0.4	-0.5
Progressive ratio test 1 breakpoint	0.0	0.1	0.2	-0.2	-0.2	-0.1	0.1	0.4	-0.5
Progressive ratio test 1 inactive lever presses	0.1	0.3	0.7	-0.5	-0.4	-0.5	0.5	-0.1	0.8
Progressive ratio test 2 active lever presses	0.0	0.0	0.1	-0.1	-0.1	-0.0	-0.1	0.2	-0.3
Progressive ratio test 2 breakpoint	0.0	0.0	0.0	-0.1	-0.2	-0.1	-0.0	0.1	-0.2
Progressive ratio test 2 inactive lever presses	0.5	1.4	1.6	-1.2	-1.2	-1.2	1.1	-1.2	1.2
Incentive Sensitization - Responses	0.0	0.1	0.5	0.1	0.1	0.1	-0.3	0.0	-0.7
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	0.2	0.2	0.2	-0.3	0.0	-0.7
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.2	0.0	0.1	-0.2	-0.0	-0.5	0.2
Progressive ratio	0.4	1.1	2.0	1.0	1.1	1.1	-1.0	0.2	-1.4
Food seeking constrained by brief footshock	2.1	2.6	3.4	1.8	1.8	1.7	-1.6	1.3	-1.4
Seeking ratio, punishment vs. effort	0.2	0.4	1.3	0.6	0.4	0.3	-0.4	1.1	-0.1
Retroperitoneal fat weight	0.1	0.6	1.0	-0.8	-0.8	-0.7	1.0	-1.0	0.2
Reaction time number correct	0.4	1.3	1.5	-1.0	-1.0	-1.2	1.1	-1.2	1.2
Reaction time mean minus median	0.4	2.6	3.7	-1.6	-1.7	-1.9	1.7	-1.3	1.1
Reaction time mean minus median AUC	0.3	2.0	2.9	-1.5	-1.7	-1.6	1.4	-1.1	1.0
Reaction time num false alarms	4.9	8.3	9.3	-2.9	-3.0	-3.0	3.1	-2.7	2.6
Reaction time num false alarms AUC	3.2	7.3	8.5	-2.7	-2.7	-2.9	2.9	-2.5	2.5
Reaction time trials correct on left	0.4	1.3	1.5	-1.0	-1.0	-1.2	1.1	-1.2	1.2
Reaction time trials on left	0.4	1.5	1.7	-1.1	-1.1	-1.3	1.3	-1.3	1.3
Reaction time mean	1.8	3.9	5.0	-2.2	-2.2	-2.2	1.9	-1.6	1.6
Reaction time mean AUC	1.6	4.0	5.1	-2.2	-2.3	-2.2	1.9	-1.6	1.6
Median of all reaction times	2.0	3.1	3.9	-2.0	-2.0	-1.8	1.6	-1.4	1.6
Reaction time omissions	2.2	3.6	5.3	-2.3	-2.3	-2.2	1.9	-1.3	0.9
Reaction time false alarm rate	2.0	2.8	3.3	-1.8	-1.8	-1.7	1.8	-1.4	1.5
Reaction time premature initiation rate	3.8	5.9	6.9	2.6	2.6	2.4	-2.4	2.4	-2.0
Reaction time premature initiations	0.8	2.4	3.1	1.7	1.8	1.5	-1.5	1.5	-1.2
Std. dev. reaction times	0.8	2.7	3.9	-1.8	-1.8	-2.0	1.8	-1.2	1.0
Reaction time trials completed	0.4	1.5	1.7	-1.1	-1.1	-1.3	1.3	-1.3	1.3
Reaction time trials AUC	0.5	1.6	1.9	-1.1	-1.2	-1.4	1.3	-1.3	1.3
Run reversals in cocaine runway, females	0.6	0.7	0.9	-0.9	-0.9	-0.9	0.7	-1.0	0.4
Run reversals in cocaine runway, males	0.1	0.1	0.4	-0.1	-0.2	-0.2	0.3	-0.7	0.1
Latency to leave start box in cocaine runway	0.1	0.2	0.5	-0.5	-0.2	-0.3	0.5	-0.7	-0.2
Latency to leave start box in cocaine runway, F	0.3	0.4	0.7	-0.7	-0.7	-0.7	0.6	-0.8	0.3
Latency to leave start box in cocaine runway, M	0.3	0.3	1.0	0.3	0.7	0.5	-0.2	0.0	-1.0
Std. dev. time between licks in bursts	0.2	0.3	0.9	0.4	0.4	0.5	-0.5	0.9	-0.2
Total sessions with >9 infusions	0.0	0.0	0.1	0.1	-0.1	0.0	-0.0	0.2	-0.1
Short access day 1 total inactive lever presses	0.0	0.0	0.1	0.1	0.1	-0.0	-0.0	0.3	-0.3
Short access day 10 total inactive lever presses	0.0	0.1	0.2	0.4	0.5	0.3	-0.4	0.4	0.1
Short access day 1 total infusions	0.3	0.7	0.8	-0.9	-0.9	-0.9	0.8	-0.7	0.8
Short access day 10 total infusions	0.1	0.1	0.2	0.4	0.3	0.3	-0.3	0.4	-0.4
Short access total infusions	0.0	0.0	0.0	-0.1	-0.2	-0.2	0.1	0.2	-0.1
Short access day 1 locomotion	1.3	2.2	2.6	-1.4	-1.6	-1.6	1.4	-1.4	1.6
Short access day 10 total locomotion	0.0	0.1	0.4	-0.2	-0.3	-0.2	-0.0	-0.3	0.6
Short access total locomotion	0.3	0.4	0.8	-0.6	-0.7	-0.6	0.5	-0.6	0.9
One hour access (0.3 mA shock)	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.2	-0.4	-0.2
Compulsive drug intake	0.1	0.1	0.5	0.1	0.2	0.1	0.1	-0.7	0.3
One hour access (shock baseline)	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.3	-0.2	-0.2
Social response proportion	0.0	0.0	0.2	-0.1	-0.0	0.0	-0.0	0.4	-0.3
Social responses	0.0	0.0	0.1	-0.3	-0.2	-0.2	0.2	-0.2	0.2
Social time	1.6	2.5	3.4	1.5	1.5	1.6	-1.8	1.8	-1.1
Soleus weight	0.0	0.1	0.5	-0.1	-0.2	0.3	-0.7	0.2	0.1
Bone: stiffness	0.1	0.1	0.2	-0.1	-0.2	-0.5	0.5	-0.0	-0.3
Tibialis anterior weight	0.5	1.7	1.9	-1.3	-1.4	-1.4	1.1	-1.3	1.4
Time to tail flick, vehicle, before self-admin	0.4	0.4	0.8	0.6	0.6	0.6	-0.9	-0.2	-0.8
Time to tail flick, vehicle, after self-admin	0.6	1.3	2.0	1.2	1.2	1.4	-1.0	0.9	-1.1
Time to tail flick, test, before self-admin	0.7	0.9	1.6	-1.0	-0.9	-0.9	0.9	-1.3	-0.2
Time to tail flick, test, after self-admin	0.7	0.7	1.1	1.1	0.9	0.9	-1.0	0.6	-0.5
Delta time to tail flick, vehicle, before/after SA	0.2	0.2	0.4	0.5	0.4	0.6	-0.3	0.6	-0.4
Delta time to tail flick, test, before/after SA	0.5	0.6	1.3	0.8	0.7	0.8	-0.8	1.1	0.1
Tibia length	0.7	1.9	3.1	-1.5	-1.6	-1.5	1.8	-0.7	0.7
Ambulatory time before self-admin	1.5	4.5	5.0	-2.2	-2.1	-2.1	2.1	-1.9	2.2
Ambulatory time after self-admin	0.1	0.1	0.5	0.2	0.3	0.2	-0.2	0.7	-0.1
Bone: tissue strength	0.1	0.1	0.4	0.1	0.2	0.3	-0.2	0.6	-0.0
Total heroin consumption	0.2	0.2	0.3	-0.5	-0.4	-0.5	0.6	-0.3	0.4
Bone: trabecular number	2.5	4.7	7.7	2.8	2.6	2.2	-2.3	1.2	-1.5
Bone: trabecular spacing	1.1	1.6	2.9	-1.7	-1.7	-1.2	1.2	-0.6	0.9
Bone: trabecular thickness	3.1	4.4	6.4	2.4	2.5	1.9	-2.1	1.6	-1.8
Bone: trabecular tissue density	0.8	1.3	2.2	-1.0	-1.0	-1.4	1.5	-1.1	0.6
Water consumed over 24 hours	1.6	3.2	3.6	1.8	1.7	1.8	-1.9	1.9	-1.6
Number of responses in last shaping day	1.7	2.2	2.9	-1.4	-1.4	-1.4	1.5	-1.5	1.7