LOC103691511

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	isoform ratio	XR_010064176.1	0.03	0.02	5.1e-03	0.02	0.01	0.01	0.01	3.1e-03	1.6e-02	1.8e-02	6.8e-03
2	Brain	gene expression	LOC103691511	0.09	0.06	3.5e-04	0.02	0.01	0.02	0.01	3.2e-03	3.3e-02	9.8e-03	1.3e-02
3	Adipose	mRNA stability	LOC103691511	0.09	0.06	5.2e-08	0.05	0.04	0.05	0.05	2.7e-06	1.8e-05	5.7e-06	6.3e-06
4	Adipose	gene expression	LOC103691511	0.09	0.06	9.8e-08	0.04	0.05	0.04	0.04	9.0e-06	1.4e-06	1.7e-05	1.3e-05
5	PL	gene expression	LOC103691511	0.03	0.02	9.0e-03	0	0.01	0.01	0.01	1.5e-01	1.8e-02	3.5e-02	4.6e-02
6	Brain	isoform ratio	XR_010064176.1	0.06	0.06	9.0e-03	0.01	0	-0	0	8.3e-02	1.9e-01	8.7e-01	2.2e-01

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.2	2.2	4.6	-1.3	-2.2	-1.8	0.2	1.6	-0.9
Area under the delay curve	0.6	1.0	2.0	0.9	1.4	1.2	-0.1	-1.1	0.5
BMI with tail	0.3	1.2	2.6	1.6	1.3	1.4	0.9	-0.4	-0.3
BMI without tail	0.3	1.6	3.4	1.8	1.4	1.4	1.3	-0.3	-0.6
Body weight	0.6	2.5	5.5	2.3	0.9	1.0	2.2	0.5	-1.6
Weight adjusted by age	0.2	0.7	2.4	0.2	-0.3	-0.6	0.9	0.6	-1.5
Bone surface	3.2	6.4	12.7	-1.8	-3.6	-3.0	0.9	2.9	-1.9
Bone volume	3.1	6.2	11.3	-1.7	-3.4	-3.0	1.0	2.9	-2.1
Breakpoint value in progressive ratio session	0.3	0.5	1.0	1.0	0.7	0.3	1.0	0.2	-0.7
Number of licking bursts	0.1	0.3	0.5	-0.6	-0.5	-0.7	-0.1	0.6	-0.3
Context. condit. distance diff. score	0.3	0.4	0.6	0.3	0.7	0.7	-0.5	-0.7	0.6
Locomotion velocity, session 1	1.1	1.2	3.2	1.8	1.1	1.2	1.1	-0.4	-0.4
Locomotion distance, session 1	0.9	1.2	2.3	1.3	0.1	0.4	1.5	0.6	-1.5
Locomotion velocity, session 2	1.0	1.2	3.0	1.7	1.0	1.2	1.1	-0.3	-0.6
Locomotion distance, session 2	1.3	1.8	4.2	1.5	0.1	0.2	2.1	1.0	-1.8
Locomotion velocity, session 3	0.0	0.0	0.1	0.1	0.3	0.1	-0.1	-0.2	0.1
Locomotion distance, session 3	0.4	0.4	0.8	-0.5	-0.5	-0.9	0.3	0.9	-0.7
Stereotopy head waving bouts, day 3	0.7	0.9	1.4	0.2	-0.8	-0.6	1.2	1.1	-1.1
Stereotopy head waving duration, day 3	0.2	0.2	0.6	0.8	0.2	0.4	0.7	0.1	-0.3
Locomotion velocity, session 7	5.0	5.5	9.4	-1.8	-2.7	-3.1	0.9	3.1	-1.7
Locomotion distance, session 7	2.6	3.3	6.0	-2.3	-2.3	-2.5	-0.6	1.7	-0.4
Stereotopy head waving bouts, day 7	0.4	0.4	0.9	0.9	0.6	0.5	1.0	0.2	-0.5
Stereotopy head waving duration, day 7	0.5	0.7	1.3	1.1	1.1	1.0	0.6	-0.4	-0.0
Locomotion velocity, session 8	2.2	2.6	5.3	2.3	2.1	2.0	1.0	-1.1	-0.1
Locomotion distance, session 8	0.7	1.1	2.5	1.6	1.1	1.1	1.0	-0.2	-0.6
Degree of sensitization distance	0.2	0.2	0.7	-0.5	-0.8	-0.4	-0.3	0.3	0.1
Degree of sensitization stereotypy	0.9	1.0	2.1	1.4	1.3	1.1	0.9	-0.4	-0.3
Conditioned locomotion	0.1	0.1	0.2	0.5	0.1	0.3	0.3	-0.0	-0.1
Cocaine response after cond. corrected	0.3	0.4	1.0	-1.0	-0.6	-0.5	-0.8	-0.0	0.6
Cocaine response after cond. not corrected	0.6	0.9	2.2	-1.5	-1.0	-0.9	-1.0	0.1	0.7
Cocaine response before conditioning	0.4	0.4	0.8	-0.7	-0.8	-0.9	0.2	0.7	-0.4
Saline control response	1.2	1.7	2.8	-0.6	-1.2	-1.4	1.0	1.7	-1.6
Bone: connectivity density	1.1	1.8	4.2	-1.4	-2.1	-1.7	-0.2	1.3	-0.5
Bone: cortical apparent density	0.7	1.1	2.2	1.4	1.5	1.3	0.2	-0.9	0.2
Bone: cortical area	0.7	1.2	2.0	0.2	-1.1	-0.9	1.3	1.3	-1.4
Bone: cortical porosity	0.4	0.4	0.6	-0.3	-0.7	-0.7	0.5	0.8	-0.7
Bone: cortical porosity	0.3	0.4	0.7	0.0	-0.5	-0.5	0.7	0.7	-0.8
Bone: cortical thickness	0.7	1.2	2.7	0.9	-0.4	-0.3	1.7	1.1	-1.6
Bone: cortical thickness	1.5	1.8	4.7	2.2	1.0	1.3	1.5	-0.3	-1.0
Bone: cortical tissue density	0.7	1.2	2.3	1.4	1.5	1.4	0.1	-0.9	0.2
Condit. Reinf. active minus inactive responses	3.7	4.2	10.3	2.4	0.6	0.5	3.2	1.4	-2.5
Condit. Reinf. active-inactive response ratio	4.6	4.9	11.7	2.6	0.6	0.7	3.4	1.4	-2.8
Condit. Reinf. active responses	3.3	4.2	10.8	2.2	0.3	0.1	3.3	1.8	-2.6
Condit. Reinf. inactive responses	0.1	0.1	0.2	0.2	0.0	-0.3	0.5	0.4	-0.3
Incentive salience index mean	3.8	4.9	11.9	2.6	0.6	0.5	3.4	1.6	-2.7
Condit. Reinf. lever presses	1.5	2.3	4.9	2.1	0.8	0.6	2.2	0.8	-1.7
Condit. Reinf. active minus inactive responses	3.3	5.0	7.8	-1.6	-2.5	-2.8	1.2	2.8	-2.1
Condit. Reinf. active-inactive response ratio	1.9	2.9	4.8	-1.0	-1.9	-2.0	1.2	2.2	-1.8
Condit. Reinf. active responses	4.7	6.7	10.6	-2.0	-3.1	-3.3	1.2	3.1	-2.2
Condit. Reinf. inactive responses	0.3	0.5	0.9	-0.5	-0.8	-0.9	0.5	0.9	-0.6
Condit. Reinf. lever presses	1.9	2.8	4.6	-1.1	-2.0	-2.0	0.9	2.1	-1.5
Condit. Reinf. lever reinforcers received	4.9	6.9	10.8	-2.1	-3.2	-3.3	1.1	3.1	-2.2
Conditioned reinforcement - actives	1.1	4.2	8.3	-2.2	-2.9	-2.7	-0.1	2.3	-0.5
Conditioned reinforcement - inactives	0.2	0.6	1.2	-0.6	-0.9	-1.1	0.3	0.9	-0.4
Conditioned locomotion	1.5	2.2	4.9	-1.3	-2.2	-1.7	0.1	1.7	-0.6
Patch foraging indifference point 0 sec	0.3	0.9	1.8	-1.2	-0.2	-0.7	-1.3	-0.4	1.2
Patch foraging indifference point AUC	0.1	0.2	0.4	0.5	0.3	0.6	-0.1	-0.6	0.4
Delay disc. indifference point, 0s delay	0.1	0.1	0.3	-0.2	0.0	0.2	-0.6	-0.4	0.5
Delay disc. indifference point, 16s delay	0.6	0.8	2.0	0.8	1.4	1.1	-0.1	-0.9	0.5
Delay disc. indifference point, 2s delay	1.1	1.2	2.6	1.2	-0.2	0.1	1.6	1.0	-1.5
Delay disc. indifference point, 24s delay	0.1	0.2	0.5	0.1	0.7	0.3	-0.2	-0.6	0.4
Delay disc. indifference point, 4s delay	1.4	1.5	3.0	1.4	1.7	1.6	0.1	-1.2	0.4
Delay disc. indifference point, 8s delay	0.4	0.6	1.1	-0.1	0.8	0.5	-0.8	-1.0	1.0
Indifference point function ln k	0.1	0.2	0.9	0.2	0.9	0.5	-0.2	-0.4	0.3
Indifference point function log k	0.1	0.2	0.9	0.2	0.9	0.5	-0.2	-0.4	0.3
Patch foraging total patch changes 0 sec	0.3	0.8	1.8	-0.9	0.2	-0.3	-1.3	-0.8	1.3
Patch foraging total patch changes 12 sec	0.4	0.5	1.1	-0.6	-0.4	-0.0	-1.1	-0.7	0.9
Patch foraging total patch changes 18 sec	0.2	0.4	0.7	0.6	0.9	0.7	-0.0	-0.8	0.5
Patch foraging total patch changes 24 sec	0.2	0.6	1.3	0.1	0.4	0.7	-0.9	-1.0	1.1
Patch foraging total patch changes 6 sec	0.2	0.3	0.7	-0.0	0.3	0.4	-0.7	-0.9	0.8
Patch foraging time to switch 0 sec	0.6	2.4	5.5	1.5	0.4	0.1	2.3	1.3	-2.2
Patch foraging water rate 0 sec	0.3	1.0	1.9	-0.4	0.4	0.6	-1.4	-1.3	1.3
Patch foraging water rate 12 sec	0.3	1.1	2.8	-1.7	-0.7	-0.9	-1.3	-0.0	1.0
Patch foraging water rate 18 sec	0.1	0.3	0.6	-0.8	-0.7	-0.4	-0.4	0.2	-0.0
Patch foraging water rate 24 sec	1.0	1.4	2.9	-0.3	1.0	0.9	-1.3	-1.4	1.7
Patch foraging water rate 6 sec	0.9	1.4	3.3	-1.8	-1.1	-1.3	-1.2	0.3	0.6
Seeking ratio, delayed vs. immediate footshock	3.4	4.8	10.6	-3.3	-2.7	-2.4	-2.0	0.8	0.9
Distance traveled before self-admin	0.2	0.5	1.1	1.1	1.0	0.9	0.3	-0.5	0.0
Distance traveled after self-admin	0.1	0.1	0.5	-0.4	0.0	-0.1	-0.4	-0.2	0.7
Extensor digitorum longus weight	5.5	22.1	51.6	7.2	4.9	5.4	4.4	-1.4	-2.4
Bone: elastic displacement	0.9	1.1	1.9	0.2	-0.7	-0.7	1.3	1.4	-1.4
Bone: elastic work	1.2	1.6	2.8	-0.1	-1.1	-1.2	1.4	1.7	-1.5
Bone: endosteal estimation	1.3	3.2	5.2	-0.9	-2.3	-1.9	1.2	2.2	-1.7
Bone: endosteal perimeter	0.4	1.0	2.4	-1.0	-1.5	-1.2	0.1	1.0	-0.4
Epididymis fat weight	0.3	1.3	3.0	1.4	1.3	1.7	0.1	-1.0	0.3
Delta time in closed arm before/after self-admin	0.5	0.4	0.8	0.0	0.4	0.6	-0.8	-0.8	0.9
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.5	-0.5	-0.7	-0.0	0.4	0.1
Diff in mean of infusions in LGA sessions	0.8	1.3	3.5	1.3	0.2	0.2	1.9	0.9	-1.5
Delay discount exponential model param	0.6	0.8	1.6	-0.8	-1.3	-1.1	0.1	1.0	-0.5
Extinction: sum of active levers before priming	0.2	0.4	1.0	0.3	-0.3	-0.5	0.7	0.6	-1.0
Active lever presses in extinction session 6	0.3	0.3	0.8	-0.4	0.4	0.1	-0.8	-0.6	0.9
Bone: final force	0.8	1.2	2.1	0.2	-1.0	-0.8	1.5	1.3	-1.4
Bone: final moment	0.8	1.4	2.1	-0.1	-1.3	-1.1	1.3	1.5	-1.3
Food consumed during 24 hour testing period	0.6	1.2	2.3	1.5	1.0	0.8	1.4	0.1	-1.2
Glucose	0.4	0.6	1.4	1.2	0.6	0.7	1.0	-0.1	-0.5
Heart weight	0.4	0.7	1.5	0.7	1.2	1.0	-0.3	-1.0	0.3
Delay discount hyperbolic model param	0.6	0.8	1.6	-1.1	-1.3	-1.1	-0.3	0.8	-0.1
Intermittent access intake day 1-15 change	0.4	2.4	4.9	-2.2	-2.0	-1.7	-1.3	0.6	0.7
Intermittent access intake escalation	0.5	2.7	5.6	-2.4	-1.9	-1.6	-1.7	0.3	1.1
Intermittent access intake escalation 2	2.4	4.1	8.2	-2.9	-2.6	-2.4	-1.6	0.9	0.7
Intermitt. access day 1 inactive lever presses	0.3	3.5	7.9	1.4	2.8	2.2	-0.4	-2.0	1.4
Intermitt. access day 15 inactive lever presses	0.5	2.7	4.6	0.1	1.9	1.5	-1.4	-2.1	2.0
Intermitt. access escalation Index	0.6	1.8	3.0	0.8	1.7	1.7	-0.8	-1.7	1.0
Intermittent access day 1 total infusions	1.2	3.5	6.9	-2.1	-2.6	-2.5	-0.1	1.7	-0.4
Intermittent access day 15 total infusions	2.6	6.3	12.3	-3.5	-3.3	-3.0	-1.6	1.4	0.9
Intermittent access terminal intake (last 3 days)	4.3	7.5	14.7	-3.8	-3.7	-3.3	-1.6	1.5	0.8
Intermittent access total infusions	4.0	4.7	9.0	-2.9	-3.0	-2.7	-1.0	1.4	0.6
Intermittent access day 1 locomotion	0.6	1.2	2.3	-1.4	-1.5	-1.4	-0.2	0.7	0.3
Intermittent access day 15 total locomotion	0.5	1.8	4.8	-1.4	-2.2	-1.6	0.1	1.2	-0.2
Intermittent access total locomotion	2.1	2.5	5.6	-2.0	-2.4	-2.0	-0.6	0.9	0.4
Intermittent access standard deviation	0.6	3.2	6.9	-2.6	-1.8	-1.5	-2.1	0.1	1.6
Left kidney weight	0.1	0.6	1.3	-0.5	0.5	0.2	-1.1	-1.0	1.0
Right kidney weight	0.0	0.2	0.5	0.4	0.5	0.5	-0.2	-0.7	0.3
Cocaine induced anxiety	0.2	0.5	1.3	0.6	1.1	0.7	-0.1	-0.8	0.5
Post-drug Anxiety	1.2	1.4	3.3	1.8	1.4	1.4	0.9	-0.4	-0.3
Baseline Anxiety	0.3	0.5	1.1	0.8	-0.2	0.2	1.0	0.7	-0.9
Tail length	0.2	0.8	1.8	1.3	0.8	0.7	1.3	0.1	-0.7
Length with tail	0.3	1.4	3.0	1.5	0.1	0.2	1.7	0.8	-1.5
Length without tail	0.2	0.9	1.5	0.2	-1.0	-0.9	0.8	1.2	-1.2
Times rat made contact with spout	0.0	0.1	0.2	-0.4	-0.1	-0.3	-0.2	0.0	0.2
Lifetime Intake	2.9	3.6	7.3	-2.7	-2.4	-2.1	-1.4	0.7	1.1
Liver weight, left	0.3	0.6	1.4	0.8	0.2	0.1	1.1	0.5	-1.2
Liver weight, right	0.5	0.8	1.7	0.4	1.0	0.9	-0.8	-1.3	0.8
Locomotor activity	0.0	0.0	0.1	0.2	-0.3	-0.0	0.1	0.1	-0.0
Locomotor testing distance	0.0	0.1	0.2	0.3	-0.1	-0.2	0.4	0.3	-0.3
Locomotor testing rearing	0.2	0.7	1.7	-1.3	-0.7	-1.1	-0.7	0.3	0.4
Locomotion in novel chamber	0.6	0.8	1.7	1.0	-0.1	0.1	1.3	0.7	-1.2
Locomotion in novel chamber post-restriction	0.1	0.2	0.5	0.0	0.3	0.4	-0.4	-0.6	0.7
Fecal boli incidents, locomotor time 1	0.0	0.1	0.1	0.4	0.2	0.1	0.3	-0.1	-0.0
Change in fecal boli incidents, locomotor task	1.2	1.3	2.5	-1.6	-1.5	-1.3	-0.9	0.6	0.2
Time >=10cm from walls, locomotor time 1	1.0	1.3	2.4	-1.2	-1.6	-1.5	-0.1	1.1	-0.3
Bouts of movement, locomotor time 1	2.8	3.7	6.4	-0.2	1.6	1.6	-2.2	-2.4	2.5
Total resting periods, locomotor time 1	2.0	2.3	4.1	-0.2	1.2	1.2	-1.9	-1.8	2.0
Rest time, locomotor task time 1	0.3	0.5	1.0	-0.1	0.4	0.6	-1.0	-0.9	0.9
Distance moved, locomotor task time 1	0.0	0.1	0.1	0.2	0.1	0.1	0.3	0.2	-0.3
Vertical activity count, locomotor time 1	0.2	1.1	2.0	0.4	-0.7	-0.6	1.3	1.3	-1.4
Time >=10cm from walls, locomotor time 2	0.5	1.4	2.5	-0.9	-1.4	-1.6	0.6	1.4	-1.0
Bouts of movement, locomotor time 2	0.9	3.1	5.1	0.5	2.0	1.8	-1.5	-2.3	1.9
Total resting periods, locomotor time 2	0.8	3.3	5.6	0.5	2.1	1.9	-1.6	-2.4	2.0
Rest time, locomotor task time 2	0.4	0.7	1.3	0.4	1.1	0.9	-0.6	-1.1	0.7
Distance moved, locomotor task time 2	0.0	0.0	0.1	-0.1	0.1	0.2	-0.2	-0.2	0.3
Vertical activity count, locomotor time 2	0.4	0.8	2.0	1.1	0.4	0.3	1.4	0.6	-1.1
Light reinforcement 1	0.4	1.7	3.4	1.1	1.5	1.8	-0.3	-1.6	0.7
Light reinforcement 2	0.8	1.9	4.1	1.9	1.4	2.0	0.7	-1.1	0.0
Bone: marrow area	1.2	3.0	4.8	-0.7	-2.2	-1.8	1.3	2.2	-1.7
Bone: maximum diameter	0.1	0.2	0.6	-0.5	-0.8	-0.6	0.1	0.4	-0.1
Bone: maximum force	0.9	1.7	2.6	0.1	-1.3	-1.0	1.6	1.6	-1.6
Bone: maximum moment	1.0	1.9	2.9	-0.3	-1.5	-1.3	1.3	1.7	-1.5
Mean time between licks in bursts	0.2	1.4	3.1	1.0	-0.0	-0.1	1.8	1.2	-1.7
Mean num. licks in bursts	0.1	0.2	0.3	0.3	0.4	0.5	-0.1	-0.6	0.4
Cd content in liver	0.8	0.9	1.7	0.5	0.9	1.2	-0.6	-1.3	1.0
Co content in liver	1.6	1.9	3.2	0.3	1.4	1.4	-1.3	-1.8	1.6
Cu content in liver	1.7	2.0	4.3	-2.1	-1.1	-1.2	-1.8	-0.2	1.3
Fe content in liver	0.7	0.8	1.5	-0.8	-0.9	-1.2	0.3	1.1	-0.7
K content in liver	0.4	0.4	1.0	-0.7	0.3	-0.1	-1.0	-0.4	0.9
Mg content in liver	0.1	0.2	0.4	-0.6	0.0	-0.3	-0.6	-0.0	0.3
Mn content in liver	0.1	0.2	0.5	0.3	0.7	0.4	-0.1	-0.3	0.1
Na content in liver	0.6	0.7	1.6	-1.3	-0.6	-0.7	-1.1	-0.2	0.7
Rb content in liver	0.2	0.3	0.8	-0.1	0.9	0.3	-0.5	-0.5	0.4
Se content in liver	0.3	0.3	0.6	-0.1	0.6	0.5	-0.7	-0.7	0.6
Sr content in liver	0.4	0.3	0.6	0.6	-0.3	-0.1	0.8	0.6	-0.8
Zn content in liver	1.6	1.8	3.4	-1.8	-1.2	-0.9	-1.8	-0.3	1.4
Bone: minimum diameter	2.9	5.6	10.1	0.5	-1.7	-1.7	3.0	2.9	-3.2
Time in familiar zone, hab. session 1	0.8	0.9	1.9	-0.5	0.6	0.5	-1.4	-1.0	1.2
Time in novel zone, hab. session 1	0.1	0.1	0.2	-0.2	-0.4	-0.4	0.4	0.3	-0.2
Total zone transitions, hab. session 1	0.9	1.3	2.8	1.5	0.1	0.6	1.5	0.5	-1.7
Total locomotion distance, hab. session 1	1.1	1.5	3.6	0.8	-0.7	-0.4	1.6	1.3	-1.9
Locomotion velocity, hab. session 1	1.2	1.8	4.0	1.1	-0.5	-0.1	1.9	1.3	-2.0
Time in familiar zone, hab. session 2	2.0	2.3	5.1	-1.1	0.8	0.4	-2.3	-1.5	2.1
Time in novel zone, hab. session 2	1.5	1.6	3.4	0.3	-1.1	-0.7	1.6	1.4	-1.8
Total zone transitions, hab. session 2	0.4	0.6	1.0	1.0	0.9	1.0	0.1	-0.7	0.2
Total locomotion distance, hab. session 2	0.1	0.2	0.5	0.5	0.0	0.0	0.7	0.3	-0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.3	0.4	0.0	0.0	0.6	0.2	-0.3
Novel to familiar place preference ratio	0.1	0.2	0.3	-0.1	-0.5	-0.3	0.5	0.6	-0.3
Novelty place preference	0.1	0.1	0.2	-0.3	-0.4	-0.3	0.2	0.4	-0.0
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	-0.2	-0.0	0.0	0.0	0.2
Total zone transitions, NPP test	0.8	1.1	2.3	1.5	1.3	1.3	0.6	-0.6	-0.6
Total locomotion distance, NPP test	0.6	0.8	2.3	0.9	-0.1	0.1	1.2	0.7	-1.5
Locomotion velocity, NPP test	0.6	0.9	2.3	0.6	-0.4	-0.3	1.2	0.9	-1.5
Intraocular pressure	1.2	2.0	3.7	1.9	0.8	0.8	1.9	0.6	-1.8
Delta distance traveled before/after self-admin	2.3	2.5	5.2	-2.3	-2.0	-2.0	-0.7	1.1	0.3
Delta ambulatory time before/after self-admin	1.5	2.6	5.6	-2.4	-2.0	-2.1	-0.8	1.0	0.3
Parametrial fat weight	0.1	0.3	0.6	0.5	-0.1	-0.1	0.7	0.5	-0.8
Pavlov. Cond. lever latency	0.4	0.6	1.2	-0.9	-0.2	-0.1	-1.1	-0.5	1.0
Pavlov. Cond. magazine entry latency	0.4	0.5	1.0	0.7	0.1	0.0	1.0	0.6	-1.0
Pavlov. Cond. change in total contacts	1.5	1.6	3.3	1.8	0.6	0.7	1.8	0.5	-1.5
Pavlov. Cond. index score	0.5	0.6	1.2	1.1	0.6	0.5	1.0	0.1	-0.7
Pavlov. Cond. latency score	0.4	0.5	1.1	1.1	0.7	0.6	0.9	0.1	-0.6
Pavlov. Cond. lever contacts	0.9	1.0	2.3	1.0	-0.1	-0.1	1.5	1.0	-1.5
Pavlov. Cond. magazine entry number	0.5	0.6	1.3	-1.2	-0.7	-0.7	-0.9	0.0	0.7
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.7	-0.9	-0.9	-0.1	0.7	-0.6
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.0	1.0	0.5	0.4	1.0	0.2	-0.8
Pavlov. Cond. response bias	0.8	0.9	2.1	1.1	0.1	0.1	1.4	0.7	-1.3
Pavlov. Cond. lever latency	0.8	1.1	2.4	1.3	1.6	1.3	0.5	-0.7	0.1
Pavlov. Cond. magazine entry latency	0.0	0.0	0.1	-0.1	-0.2	-0.1	0.1	0.2	-0.3
Pavlov. Cond. change in total contacts	1.0	2.5	4.2	-0.2	-1.5	-1.5	1.5	2.0	-2.0
Pavlov. Cond. index score	0.7	1.1	1.8	-0.4	-1.2	-1.1	0.8	1.3	-1.2
Pavlov. Cond. latency score	0.6	0.9	1.5	-0.6	-1.2	-1.1	0.4	1.2	-0.9
Pavlov. Cond. lever contacts	0.5	0.7	1.5	-0.9	-1.2	-1.1	-0.1	0.8	-0.4
Pavlov. Cond. magazine entry number	0.2	0.3	0.7	-0.1	0.3	0.3	-0.5	-0.6	0.9
Pavlov. Cond. intertrial magazine entries	0.2	0.4	0.9	0.7	0.0	-0.0	1.0	0.6	-0.8
Pavlov. Cond. lever-magazine prob. diff.	0.7	1.0	1.6	-0.4	-1.2	-1.1	0.7	1.3	-1.2
Pavlov. Cond. response bias	0.7	1.0	1.5	-0.6	-1.2	-1.2	0.6	1.2	-1.0
Time in closed arm before self-admin	0.3	0.6	1.5	-1.2	-0.1	-0.5	-1.1	-0.3	0.6
Time in closed arm after self-admin	1.2	1.4	2.4	-0.5	0.8	0.9	-1.6	-1.4	1.5
Time in open arm before self-admin	0.5	0.6	1.1	0.1	-0.9	-0.5	0.9	1.0	-0.9
Time in open arm after self-admin	0.3	0.3	0.8	0.7	0.1	0.1	0.9	0.3	-0.5
Bone: periosteal estimation	1.7	4.1	6.3	-0.2	-2.2	-1.8	2.1	2.5	-2.4
Bone: periosteal perimeter	0.5	1.0	2.3	-0.6	-1.5	-1.1	0.5	1.0	-0.7
Bone: post-yield work	1.8	3.1	6.1	-2.5	-2.4	-2.1	-1.2	0.8	0.3
Progressive ratio test 1 active lever presses	1.0	1.7	3.5	-1.9	-1.4	-1.2	-1.3	0.0	1.3
Progressive ratio test 1 breakpoint	1.0	1.8	3.6	-1.9	-1.5	-1.3	-1.2	0.1	1.2
Progressive ratio test 1 inactive lever presses	0.0	0.1	0.4	-0.3	0.3	-0.2	-0.1	-0.0	0.6
Progressive ratio test 2 active lever presses	2.9	4.1	8.4	-2.4	-2.9	-2.6	-0.6	1.8	0.0
Progressive ratio test 2 breakpoint	3.1	3.9	8.0	-2.4	-2.8	-2.6	-0.5	1.8	-0.0
Progressive ratio test 2 inactive lever presses	0.4	1.1	2.2	-1.5	-1.4	-1.3	-0.6	0.6	0.4
Incentive Sensitization - Responses	1.5	4.3	7.7	-1.5	-2.8	-2.5	0.7	2.6	-1.5
Incentive Sensitization - Breakpoint	1.8	4.0	7.3	-1.5	-2.7	-2.5	0.6	2.5	-1.4
Sum of active levers in priming session hrs 5-6	1.4	1.3	2.0	-0.5	-1.3	-1.4	0.6	1.4	-1.4
Progressive ratio	0.5	1.5	3.6	-1.1	-0.2	0.4	-1.9	-1.3	1.6
Food seeking constrained by brief footshock	2.1	2.7	5.5	2.3	0.6	0.8	2.3	0.8	-1.9
Seeking ratio, punishment vs. effort	1.4	3.2	7.3	2.2	0.7	0.4	2.7	1.3	-2.2
Retroperitoneal fat weight	0.1	0.5	1.3	1.1	0.8	0.8	0.6	-0.2	-0.3
Reaction time number correct	0.4	1.3	2.3	-0.7	-1.4	-1.3	0.8	1.5	-1.0
Reaction time mean minus median	0.4	2.3	4.6	1.8	2.1	1.9	0.3	-1.5	0.3
Reaction time mean minus median AUC	0.3	2.3	4.3	2.0	2.1	1.9	0.8	-1.2	-0.1
Reaction time num false alarms	1.7	3.0	4.7	-1.4	-2.1	-2.2	0.7	2.0	-1.4
Reaction time num false alarms AUC	1.3	2.9	4.9	-1.5	-2.1	-2.2	0.5	1.9	-1.3
Reaction time trials correct on left	0.4	1.3	2.3	-0.7	-1.4	-1.3	0.8	1.5	-1.0
Reaction time trials on left	0.4	1.3	2.3	-0.6	-1.4	-1.2	0.8	1.5	-1.0
Reaction time mean	0.6	1.4	2.8	1.7	1.2	1.2	1.2	-0.3	-0.9
Reaction time mean AUC	0.5	1.3	2.7	1.6	1.1	1.1	1.3	-0.2	-1.1
Median of all reaction times	0.8	1.2	2.2	1.4	0.6	0.7	1.5	0.3	-1.5
Reaction time omissions	1.7	2.8	6.1	2.5	1.7	2.2	1.3	-1.0	-0.7
Reaction time false alarm rate	0.2	0.3	0.6	-0.8	-0.7	-0.8	-0.2	0.4	-0.1
Reaction time premature initiation rate	0.7	1.2	3.1	-1.4	-0.6	-0.4	-1.7	-0.6	1.1
Reaction time premature initiations	0.3	1.0	2.4	-1.5	-1.1	-0.9	-1.2	0.1	0.6
Std. dev. reaction times	0.4	1.4	2.4	1.4	1.6	1.5	0.2	-1.2	0.3
Reaction time trials completed	0.4	1.3	2.3	-0.6	-1.4	-1.2	0.8	1.5	-1.0
Reaction time trials AUC	0.4	1.3	2.4	-0.5	-1.3	-1.2	0.9	1.5	-1.1
Run reversals in cocaine runway, females	0.2	0.2	0.8	0.9	0.1	0.5	0.3	-0.2	-0.4
Run reversals in cocaine runway, males	1.3	1.4	3.0	1.7	0.7	0.7	1.6	0.3	-1.4
Latency to leave start box in cocaine runway	0.4	0.6	1.1	-1.1	-0.9	-1.1	-0.6	0.3	0.1
Latency to leave start box in cocaine runway, F	1.6	2.0	4.1	-2.0	-1.6	-1.8	-1.1	0.7	0.4
Latency to leave start box in cocaine runway, M	1.1	1.1	2.5	1.6	1.1	1.2	0.9	-0.5	-0.5
Std. dev. time between licks in bursts	0.2	0.4	0.7	0.2	-0.6	-0.4	0.7	0.8	-0.8
Total sessions with >9 infusions	1.4	1.7	3.6	-1.9	-0.8	-0.9	-1.6	-0.4	1.6
Short access day 1 total inactive lever presses	0.8	1.7	3.7	-1.2	0.4	0.1	-1.9	-1.2	1.8
Short access day 10 total inactive lever presses	0.3	1.8	4.1	0.8	2.0	1.6	-0.7	-1.4	1.1
Short access day 1 total infusions	0.8	1.6	3.4	-1.6	-0.9	-0.6	-1.8	-0.5	1.4
Short access day 10 total infusions	1.3	2.2	4.9	-2.2	-1.6	-1.7	-1.2	0.4	1.0
Short access total infusions	1.2	1.8	3.8	-2.0	-1.3	-1.2	-1.3	0.0	1.3
Short access day 1 locomotion	0.4	0.6	1.7	-0.8	0.1	-0.1	-1.0	-0.7	1.3
Short access day 10 total locomotion	0.1	0.3	0.6	0.4	0.4	0.5	-0.1	-0.7	0.8
Short access total locomotion	0.4	0.6	1.3	-1.2	-0.7	-0.7	-0.7	-0.1	1.0
One hour access (0.3 mA shock)	4.0	4.8	9.9	-2.6	-3.1	-2.8	-0.5	1.9	-0.3
Compulsive drug intake	0.8	1.2	3.4	1.2	1.9	1.3	0.2	-0.7	0.1
One hour access (shock baseline)	3.3	8.7	18.1	-3.6	-4.3	-3.9	-0.8	2.4	-0.3
Social response proportion	0.3	0.4	0.6	0.4	0.8	0.7	-0.2	-0.8	0.7
Social responses	0.7	0.9	1.5	0.8	1.1	1.2	-0.3	-1.2	0.9
Social time	0.1	0.2	0.4	-0.5	-0.4	-0.6	0.2	0.3	-0.2
Soleus weight	0.4	1.3	2.7	1.6	1.2	1.1	1.3	-0.2	-0.8
Bone: stiffness	0.3	0.5	0.8	0.2	-0.6	-0.5	0.9	0.7	-0.9
Tibialis anterior weight	4.2	14.5	33.6	5.8	3.3	3.7	4.5	-0.1	-2.8
Time to tail flick, vehicle, before self-admin	0.3	0.3	0.7	-0.2	-0.9	-0.7	0.2	0.8	-0.1
Time to tail flick, vehicle, after self-admin	0.7	1.5	2.9	-1.7	-1.6	-1.1	-1.0	0.6	0.9
Time to tail flick, test, before self-admin	0.7	0.8	1.9	0.1	0.9	0.7	-0.9	-1.1	1.4
Time to tail flick, test, after self-admin	1.0	1.1	2.7	-1.6	-0.6	-0.8	-1.2	-0.2	1.0
Delta time to tail flick, vehicle, before/after SA	1.3	1.4	3.5	-1.9	-1.2	-1.2	-1.1	0.4	0.7
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	-0.3	0.1	-0.0	-0.3	-0.3	0.1
Tibia length	0.6	1.7	3.4	-1.8	-1.0	-1.0	-1.6	-0.1	1.5
Ambulatory time before self-admin	0.3	1.0	2.2	1.5	1.2	1.2	0.7	-0.4	-0.5
Ambulatory time after self-admin	0.3	0.5	0.9	-0.8	-0.8	-1.0	0.1	0.7	-0.2
Bone: tissue strength	1.8	1.9	4.8	-2.2	-1.1	-1.4	-1.5	0.1	1.1
Total heroin consumption	0.7	0.8	1.5	-0.3	-0.8	-1.2	0.8	1.2	-0.9
Bone: trabecular number	0.4	0.8	2.1	-0.8	-1.4	-1.1	-0.1	0.8	-0.4
Bone: trabecular spacing	1.1	1.6	3.7	1.1	1.9	1.6	-0.1	-1.3	0.7
Bone: trabecular thickness	2.5	3.5	7.0	-1.5	-2.7	-2.3	0.5	2.0	-1.4
Bone: trabecular tissue density	1.2	2.1	3.8	1.8	1.9	1.9	0.4	-1.4	0.1
Water consumed over 24 hours	0.0	0.1	0.1	0.3	0.3	0.1	0.3	0.0	-0.4
Number of responses in last shaping day	0.4	0.5	1.1	-1.0	-0.6	-0.8	-0.8	-0.0	0.7