Hub : Genes

LOC103691511

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Brain	gene expression	LOC103691511	0.05	0.04	9.9e-03	0.01	0	-0	0.01	5.3e-02	1.1e-01	3.8e-01	7.3e-02
2	Adipose	mRNA stability	LOC103691511	0.12	0.08	8.0e-11	0.03	0.06	0.04	0.05	2.1e-04	1.0e-06	8.7e-06	5.1e-06
3	IL	gene expression	LOC103691511	0.27	0.16	8.8e-03	-0.01	-0.01	-0	0.05	5.1e-01	4.8e-01	3.7e-01	2.7e-02
4	Adipose	gene expression	LOC103691511	0.07	0.05	3.0e-06	0.02	0.04	0.03	0.03	8.7e-04	4.3e-05	9.3e-05	1.6e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	2.0	3.3	5.6	-2.4	1.9	2.0	-0.2
Area under the delay curve	1.3	1.3	2.2	1.5	-1.3	-1.2	0.3
BMI with tail	0.9	3.0	6.8	0.6	-1.8	-1.3	2.6
BMI without tail	2.6	5.5	7.4	1.6	-2.7	-2.3	2.6
Body weight	0.3	1.4	4.4	0.2	-0.9	-0.6	2.1
Weight adjusted by age	0.1	0.1	0.3	-0.2	-0.1	0.4	0.5
Bone surface	4.8	8.4	14.1	-3.8	3.0	3.2	0.4
Bone volume	4.7	8.0	13.4	-3.7	2.9	3.2	0.5
Breakpoint value in progressive ratio session	1.0	1.1	1.4	1.2	-1.1	-0.7	1.2
Number of licking bursts	0.9	1.0	2.2	-1.5	1.0	1.0	-0.2
Context. condit. distance diff. score	0.3	0.4	0.6	0.8	-0.5	-0.8	-0.4
Locomotion velocity, session 1	1.9	2.0	2.6	1.4	-1.6	-1.5	1.2
Locomotion distance, session 1	0.7	0.9	2.5	0.5	-0.7	-0.5	1.6
Locomotion velocity, session 2	1.4	1.6	2.1	1.2	-1.4	-1.2	1.3
Locomotion distance, session 2	0.9	1.2	4.4	0.2	-0.6	-0.1	2.1
Locomotion velocity, session 3	0.1	0.1	0.3	0.5	-0.2	-0.3	-0.2
Locomotion distance, session 3	0.2	0.3	0.5	-0.3	0.6	0.7	0.3
Stereotopy head waving bouts, day 3	0.3	0.4	1.2	-0.2	0.2	0.5	1.1
Stereotopy head waving duration, day 3	0.4	0.5	0.7	0.8	-0.7	-0.5	0.8
Locomotion velocity, session 7	6.3	6.9	10.5	-2.8	3.0	3.2	0.6
Locomotion distance, session 7	3.7	4.7	6.8	-2.3	2.6	2.5	-0.8
Stereotopy head waving bouts, day 7	0.4	0.5	1.2	0.7	-0.5	-0.2	1.1
Stereotopy head waving duration, day 7	1.0	1.2	1.8	1.4	-1.2	-1.1	0.7
Locomotion velocity, session 8	3.1	3.7	5.1	1.9	-2.3	-2.1	1.2
Locomotion distance, session 8	0.9	1.4	1.5	1.2	-1.2	-1.0	1.2
Degree of sensitization distance	0.7	0.7	1.6	-1.3	0.7	0.7	-0.3
Degree of sensitization stereotypy	1.3	1.4	1.8	1.2	-1.3	-1.1	1.0
Conditioned locomotion	0.1	0.2	0.2	0.4	-0.4	-0.4	0.4
Cocaine response after cond. corrected	0.7	0.8	1.0	-1.0	0.9	0.7	-0.9
Cocaine response after cond. not corrected	1.4	1.5	1.9	-1.4	1.3	1.2	-1.1
Cocaine response before conditioning	0.4	0.5	0.9	-0.8	0.7	1.0	0.1
Saline control response	2.2	2.8	4.0	-2.0	1.7	2.0	0.7
Bone: connectivity density	1.8	2.9	4.5	-2.1	1.9	1.8	-0.5
Bone: cortical apparent density	1.3	1.7	2.7	1.6	-1.4	-1.5	0.3
Bone: cortical area	0.8	1.2	2.0	-1.4	0.8	1.2	1.0
Bone: cortical porosity	0.3	0.3	0.4	-0.7	0.4	0.6	0.6
Bone: cortical porosity	0.2	0.2	0.5	-0.4	0.2	0.4	0.7
Bone: cortical thickness	0.4	0.6	1.9	-0.7	0.1	0.5	1.4
Bone: cortical thickness	1.3	1.5	2.5	0.4	-1.6	-1.1	1.5
Bone: cortical tissue density	1.4	1.8	2.8	1.7	-1.4	-1.5	0.3
Condit. Reinf. active minus inactive responses	2.8	3.1	10.8	0.4	-1.2	-0.3	3.3
Condit. Reinf. active-inactive response ratio	3.5	3.8	12.5	0.5	-1.5	-0.6	3.5
Condit. Reinf. active responses	2.4	2.9	10.9	0.3	-0.9	0.1	3.3
Condit. Reinf. inactive responses	0.1	0.1	0.3	0.5	-0.0	0.2	0.5
Incentive salience index mean	2.9	3.6	12.3	0.5	-1.3	-0.3	3.5
Condit. Reinf. lever presses	1.3	1.7	5.0	0.7	-1.1	-0.5	2.2
Condit. Reinf. active minus inactive responses	4.9	6.1	9.3	-3.1	2.6	2.8	0.8
Condit. Reinf. active-inactive response ratio	3.3	3.5	5.4	-2.3	1.8	2.1	0.8
Condit. Reinf. active responses	5.7	7.9	11.1	-3.3	3.0	3.3	0.7
Condit. Reinf. inactive responses	0.4	0.5	0.9	-0.5	0.8	1.0	0.3
Condit. Reinf. lever presses	2.4	3.3	4.6	-2.1	1.9	2.1	0.6
Condit. Reinf. lever reinforcers received	6.0	8.4	12.0	-3.5	3.1	3.4	0.6
Conditioned reinforcement - actives	2.5	2.5	4.3	-1.5	2.1	1.7	-0.6
Conditioned reinforcement - inactives	0.1	0.1	0.3	0.0	0.3	0.6	0.1
Conditioned locomotion	1.6	1.9	3.2	-1.6	1.8	1.4	-0.3
Patch foraging indifference point 0 sec	0.5	0.8	2.2	-0.7	0.7	0.4	-1.5
Patch foraging indifference point AUC	0.3	0.4	0.8	0.2	-0.9	-0.8	-0.0
Delay disc. indifference point, 0s delay	0.1	0.1	0.2	-0.3	-0.0	-0.3	-0.4
Delay disc. indifference point, 16s delay	1.7	1.7	3.6	1.9	-1.4	-1.2	0.2
Delay disc. indifference point, 2s delay	0.6	0.6	2.4	-0.3	-0.2	0.1	1.6
Delay disc. indifference point, 24s delay	0.3	0.3	0.6	0.8	-0.5	-0.4	-0.3
Delay disc. indifference point, 4s delay	2.0	2.1	2.9	1.7	-1.7	-1.6	0.4
Delay disc. indifference point, 8s delay	0.6	0.6	1.0	1.0	-0.6	-0.6	-0.7
Indifference point function ln k	0.3	0.4	0.9	0.9	-0.5	-0.8	-0.1
Indifference point function log k	0.3	0.4	0.9	0.9	-0.5	-0.8	-0.1
Patch foraging total patch changes 0 sec	0.4	0.6	2.2	-0.3	0.2	-0.1	-1.5
Patch foraging total patch changes 12 sec	0.6	0.7	1.7	-1.0	0.3	0.2	-1.3
Patch foraging total patch changes 18 sec	0.5	0.6	1.1	0.7	-1.0	-0.9	-0.1
Patch foraging total patch changes 24 sec	0.4	0.5	1.1	0.3	-0.4	-0.8	-1.0
Patch foraging total patch changes 6 sec	0.2	0.3	0.6	-0.0	-0.5	-0.6	-0.8
Patch foraging time to switch 0 sec	1.1	1.7	5.5	0.8	-0.7	-0.2	2.4
Patch foraging water rate 0 sec	0.3	0.5	1.7	-0.4	-0.2	-0.4	-1.3
Patch foraging water rate 12 sec	0.8	1.2	2.1	-0.5	1.2	0.9	-1.4
Patch foraging water rate 18 sec	0.6	0.8	1.4	-1.2	0.8	0.7	-0.6
Patch foraging water rate 24 sec	0.6	0.9	1.4	0.9	-0.5	-1.0	-1.2
Patch foraging water rate 6 sec	1.3	1.9	2.3	-1.2	1.5	1.3	-1.4
Seeking ratio, delayed vs. immediate footshock	6.2	7.2	8.9	-2.5	3.0	2.7	-2.4
Distance traveled before self-admin	0.2	0.2	0.5	0.7	-0.1	-0.2	-0.4
Distance traveled after self-admin	0.4	0.5	0.8	0.9	-0.3	-0.4	-0.9
Extensor digitorum longus weight	6.8	26.9	34.6	4.8	-5.9	-4.9	5.1
Bone: elastic displacement	0.5	0.6	1.5	-0.3	0.4	0.8	1.2
Bone: elastic work	0.7	0.9	1.3	-1.0	0.7	1.0	1.1
Bone: endosteal estimation	1.8	3.9	6.2	-2.5	2.0	2.2	1.0
Bone: endosteal perimeter	0.8	1.7	2.5	-1.6	1.5	1.5	-0.0
Epididymis fat weight	0.7	1.6	2.2	1.5	-0.9	-1.5	-1.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.5	0.1	0.0	-0.3	-0.7
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.0	0.1	0.1	-0.2
Diff in mean of infusions in LGA sessions	1.0	1.1	3.3	0.3	-0.9	-0.6	1.8
Delay discount exponential model param	0.9	1.0	1.7	-1.3	1.1	0.9	-0.2
Extinction: sum of active levers before priming	0.4	0.4	0.7	0.1	-0.8	-0.6	0.7
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.0	0.5	0.4	-0.4
Bone: final force	0.7	1.1	2.0	-1.4	0.6	0.9	1.1
Bone: final moment	0.9	1.5	2.8	-1.7	1.0	1.2	0.8
Food consumed during 24 hour testing period	0.9	1.1	1.9	0.7	-1.2	-0.8	1.4
Glucose	0.6	1.0	1.5	0.6	-1.2	-0.8	1.2
Heart weight	0.7	1.0	2.4	-0.4	1.0	0.5	-1.5
Delay discount hyperbolic model param	1.1	1.2	1.8	-1.3	1.3	1.1	-0.4
Intermittent access intake day 1-15 change	2.7	2.7	5.3	-1.2	1.7	1.1	-2.3
Intermittent access intake escalation	2.2	2.2	3.9	-1.2	1.5	1.0	-2.0
Intermittent access intake escalation 2	4.1	4.0	4.9	-2.0	2.2	1.9	-1.9
Intermitt. access day 1 inactive lever presses	3.7	4.0	6.9	2.6	-1.8	-2.3	-0.6
Intermitt. access day 15 inactive lever presses	2.3	2.6	5.0	2.2	-1.1	-1.4	-1.5
Intermitt. access escalation Index	0.2	0.2	0.3	0.5	-0.4	-0.4	-0.2
Intermittent access day 1 total infusions	1.8	2.1	3.6	-1.4	1.7	1.9	-0.4
Intermittent access day 15 total infusions	5.1	5.7	8.1	-2.1	2.8	2.7	-1.8
Intermittent access terminal intake (last 3 days)	5.6	6.1	7.7	-2.3	2.8	2.7	-2.0
Intermittent access total infusions	3.4	3.7	5.0	-1.8	2.2	2.2	-1.4
Intermittent access day 1 locomotion	0.5	0.5	1.1	-0.5	0.8	1.1	-0.3
Intermittent access day 15 total locomotion	1.4	1.5	2.5	-1.6	1.2	1.4	-0.2
Intermittent access total locomotion	0.9	1.0	1.5	-0.9	1.1	1.2	-0.8
Intermittent access standard deviation	2.3	2.4	7.4	-0.4	1.3	0.6	-2.7
Left kidney weight	0.6	1.6	4.3	-0.5	1.1	0.7	-2.1
Right kidney weight	0.4	1.1	4.3	-0.4	0.3	-0.1	-2.1
Cocaine induced anxiety	0.7	0.8	1.8	1.3	-0.8	-0.7	-0.4
Post-drug Anxiety	2.5	2.8	4.3	2.1	-1.7	-1.9	0.7
Baseline Anxiety	0.2	0.2	0.6	-0.5	0.1	0.0	0.7
Tail length	0.3	1.0	1.4	0.9	-1.2	-1.1	0.7
Length with tail	0.0	0.1	0.1	-0.3	0.2	0.1	0.3
Length without tail	0.8	1.8	2.6	-1.6	1.6	1.4	-0.1
Times rat made contact with spout	0.1	0.1	0.1	-0.1	0.2	0.3	-0.3
Lifetime Intake	2.9	3.3	4.3	-1.6	2.1	2.0	-1.6
Liver weight, left	0.9	1.5	2.7	1.3	-1.2	-0.6	1.6
Liver weight, right	0.2	0.3	0.6	0.5	-0.7	-0.6	-0.1
Locomotor activity	0.0	0.0	0.1	0.3	-0.1	-0.1	0.0
Locomotor testing distance	0.0	0.0	0.1	0.3	0.0	0.1	0.2
Locomotor testing rearing	0.4	0.7	0.9	-0.3	1.0	1.0	-0.9
Locomotion in novel chamber	0.4	0.4	1.2	0.1	-0.6	-0.3	1.1
Locomotion in novel chamber post-restriction	0.2	0.2	0.5	0.7	-0.2	-0.2	-0.4
Fecal boli incidents, locomotor time 1	0.2	0.2	0.5	0.7	-0.4	-0.2	0.4
Change in fecal boli incidents, locomotor task	2.4	2.3	3.9	-2.0	1.6	1.4	-0.9
Time >=10cm from walls, locomotor time 1	2.2	2.2	3.1	-1.8	1.6	1.8	-0.2
Bouts of movement, locomotor time 1	2.1	2.3	4.1	1.4	-0.9	-1.5	-2.0
Total resting periods, locomotor time 1	1.2	1.4	2.9	0.9	-0.6	-1.2	-1.7
Rest time, locomotor task time 1	0.6	0.6	1.9	0.2	-0.2	-0.7	-1.4
Distance moved, locomotor task time 1	0.0	0.0	0.1	0.2	0.2	0.3	0.2
Vertical activity count, locomotor time 1	0.7	0.8	1.4	-0.6	0.6	0.9	1.2
Time >=10cm from walls, locomotor time 2	1.8	2.0	3.0	-1.6	1.4	1.7	0.5
Bouts of movement, locomotor time 2	2.4	2.6	3.7	1.9	-1.4	-1.7	-1.3
Total resting periods, locomotor time 2	2.5	2.6	3.4	1.8	-1.5	-1.8	-1.4
Rest time, locomotor task time 2	0.6	0.6	1.0	0.8	-0.9	-1.0	-0.4
Distance moved, locomotor task time 2	0.0	0.0	0.1	0.0	0.1	-0.0	-0.3
Vertical activity count, locomotor time 2	0.5	0.5	1.9	0.2	-0.4	-0.1	1.4
Light reinforcement 1	1.1	1.9	2.9	1.4	-1.7	-1.7	-0.1
Light reinforcement 2	1.9	2.5	3.9	1.6	-2.0	-1.7	0.9
Bone: marrow area	1.7	3.7	5.8	-2.4	1.8	2.1	1.1
Bone: maximum diameter	0.3	0.6	0.8	-0.9	0.8	0.9	-0.1
Bone: maximum force	0.9	1.6	2.5	-1.6	0.9	1.2	1.2
Bone: maximum moment	1.2	2.1	3.4	-1.9	1.3	1.5	0.9
Mean time between licks in bursts	0.6	0.9	3.4	-0.0	-0.4	0.0	1.8
Mean num. licks in bursts	0.6	0.7	1.6	1.2	-0.7	-0.7	-0.1
Cd content in liver	2.0	2.2	3.8	1.3	-1.7	-1.9	-0.6
Co content in liver	1.3	1.5	2.5	1.6	-1.1	-1.4	-0.7
Cu content in liver	2.6	3.2	4.1	-1.8	1.9	1.5	-2.0
Fe content in liver	2.3	2.8	3.6	-1.9	1.5	1.8	1.4
K content in liver	0.3	0.3	1.0	0.3	0.3	-0.0	-1.0
Mg content in liver	0.2	0.2	0.4	-0.3	0.6	0.4	-0.4
Mn content in liver	0.4	0.4	0.9	1.0	-0.6	-0.6	0.3
Na content in liver	0.5	0.6	1.3	-0.4	0.7	0.5	-1.2
Rb content in liver	0.2	0.2	0.5	0.7	-0.3	-0.4	-0.3
Se content in liver	0.1	0.1	0.4	-0.1	0.1	-0.1	-0.6
Sr content in liver	0.5	0.4	0.6	0.5	-0.7	-0.6	0.8
Zn content in liver	0.8	0.9	2.0	-0.8	0.9	0.5	-1.4
Bone: minimum diameter	2.2	4.1	8.0	-2.0	1.1	1.8	2.8
Time in familiar zone, hab. session 1	0.8	0.7	1.8	1.0	-0.1	-0.4	-1.3
Time in novel zone, hab. session 1	0.2	0.2	0.6	-0.7	0.1	0.2	0.3
Total zone transitions, hab. session 1	0.6	0.8	2.3	0.3	-0.8	-0.5	1.5
Total locomotion distance, hab. session 1	0.5	0.7	2.4	-0.4	0.1	0.5	1.5
Locomotion velocity, hab. session 1	0.6	0.9	3.3	-0.3	-0.2	0.2	1.8
Time in familiar zone, hab. session 2	1.4	1.4	5.1	0.7	0.3	-0.3	-2.3
Time in novel zone, hab. session 2	1.0	1.0	2.4	-1.0	0.2	0.7	1.6
Total zone transitions, hab. session 2	0.7	0.9	1.7	1.3	-1.0	-1.1	0.2
Total locomotion distance, hab. session 2	0.2	0.2	0.5	0.4	-0.2	-0.1	0.7
Locomotion velocity, hab. session 2	0.1	0.2	0.3	0.5	-0.2	-0.1	0.6
Novel to familiar place preference ratio	0.2	0.2	0.4	-0.6	0.3	0.5	0.5
Novelty place preference	0.2	0.2	0.2	-0.5	0.3	0.5	0.2
Time in novel zone, NPP test	0.0	0.0	0.1	-0.3	0.1	0.2	0.1
Total zone transitions, NPP test	1.0	1.4	2.2	1.5	-1.3	-1.2	0.7
Total locomotion distance, NPP test	0.3	0.4	1.4	0.1	-0.3	0.0	1.2
Locomotion velocity, NPP test	0.2	0.3	1.2	-0.1	0.1	0.4	1.1
Intraocular pressure	1.1	1.5	3.9	0.1	-1.2	-0.8	2.0
Delta distance traveled before/after self-admin	0.6	0.7	1.1	-1.0	0.9	0.8	-0.5
Delta ambulatory time before/after self-admin	1.2	1.3	2.0	-1.4	1.1	1.0	-0.9
Parametrial fat weight	0.6	1.2	2.5	1.6	-1.0	-1.1	0.1
Pavlov. Cond. lever latency	0.3	0.4	1.4	-0.2	0.5	0.2	-1.2
Pavlov. Cond. magazine entry latency	0.2	0.3	1.1	-0.2	-0.2	0.1	1.0
Pavlov. Cond. change in total contacts	1.3	1.4	3.7	0.2	-1.1	-0.7	1.9
Pavlov. Cond. index score	0.5	0.6	1.2	0.5	-0.8	-0.5	1.1
Pavlov. Cond. latency score	0.5	0.6	1.0	0.6	-0.8	-0.6	1.0
Pavlov. Cond. lever contacts	0.5	0.6	2.4	-0.1	-0.3	0.1	1.5
Pavlov. Cond. magazine entry number	0.4	0.5	0.9	-0.3	0.8	0.6	-0.9
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.8	-0.6	0.9	0.9	-0.2
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.5	1.1	0.4	-0.8	-0.5	1.1
Pavlov. Cond. response bias	0.4	0.5	1.9	-0.1	-0.4	-0.1	1.4
Pavlov. Cond. lever latency	1.2	1.7	2.2	1.5	-1.4	-1.4	0.7
Pavlov. Cond. magazine entry latency	0.0	0.1	0.1	-0.2	0.2	0.4	0.1
Pavlov. Cond. change in total contacts	1.6	2.2	2.8	-1.7	1.2	1.6	1.3
Pavlov. Cond. index score	1.0	1.3	1.9	-1.4	1.1	1.3	0.6
Pavlov. Cond. latency score	0.9	1.1	1.7	-1.3	1.1	1.2	0.3
Pavlov. Cond. lever contacts	0.9	1.3	1.7	-1.3	1.3	1.3	-0.3
Pavlov. Cond. magazine entry number	0.2	0.2	0.3	0.4	-0.3	-0.5	-0.5
Pavlov. Cond. intertrial magazine entries	0.2	0.2	0.8	0.2	-0.2	-0.2	0.9
Pavlov. Cond. lever-magazine prob. diff.	1.0	1.2	1.8	-1.4	1.1	1.3	0.5
Pavlov. Cond. response bias	1.2	1.6	2.4	-1.6	1.3	1.5	0.4
Time in closed arm before self-admin	0.2	0.2	0.7	-0.1	0.4	0.1	-0.8
Time in closed arm after self-admin	0.5	0.5	1.6	0.0	0.0	-0.5	-1.3
Time in open arm before self-admin	0.7	0.8	1.3	-0.6	0.7	1.2	1.0
Time in open arm after self-admin	0.4	0.5	1.0	0.4	-0.8	-0.3	1.0
Bone: periosteal estimation	2.1	4.3	6.6	-2.6	1.7	2.2	1.7
Bone: periosteal perimeter	0.9	1.6	2.4	-1.6	1.3	1.5	0.3
Bone: post-yield work	2.8	3.8	4.7	-2.1	2.2	2.0	-1.4
Progressive ratio test 1 active lever presses	1.6	1.7	5.7	0.2	0.8	0.5	-2.4
Progressive ratio test 1 breakpoint	1.5	1.6	4.9	-0.1	1.0	0.7	-2.2
Progressive ratio test 1 inactive lever presses	0.8	0.9	1.9	1.4	-0.4	-0.7	-1.0
Progressive ratio test 2 active lever presses	2.1	2.3	3.2	-1.3	1.8	1.7	-1.2
Progressive ratio test 2 breakpoint	2.2	2.5	3.5	-1.5	1.9	1.8	-0.9
Progressive ratio test 2 inactive lever presses	1.0	1.2	1.8	-0.5	1.3	1.3	-1.0
Incentive Sensitization - Responses	3.0	3.1	4.8	-1.9	1.9	2.2	0.4
Incentive Sensitization - Breakpoint	2.8	2.8	4.2	-1.9	1.8	2.1	0.2
Sum of active levers in priming session hrs 5-6	0.5	0.5	0.7	-0.7	0.7	0.8	0.5
Progressive ratio	0.7	0.8	3.1	0.2	0.3	0.2	-1.8
Food seeking constrained by brief footshock	1.6	2.0	5.7	0.7	-1.2	-0.7	2.4
Seeking ratio, punishment vs. effort	2.1	2.5	8.3	0.3	-1.0	-0.8	2.9
Retroperitoneal fat weight	0.0	0.1	0.2	0.2	0.0	-0.2	-0.5
Reaction time number correct	0.8	1.2	1.7	-1.2	1.1	1.3	0.6
Reaction time mean minus median	3.3	4.3	8.1	2.8	-2.3	-1.9	0.5
Reaction time mean minus median AUC	3.3	4.3	7.7	2.8	-2.3	-1.8	1.0
Reaction time num false alarms	2.5	3.4	5.1	-2.1	1.9	2.3	0.6
Reaction time num false alarms AUC	2.2	3.0	4.5	-2.0	1.8	2.1	0.4
Reaction time trials correct on left	0.8	1.2	1.7	-1.2	1.1	1.3	0.6
Reaction time trials on left	0.8	1.1	1.6	-1.1	1.1	1.3	0.7
Reaction time mean	1.6	2.3	3.3	1.8	-1.6	-1.2	1.3
Reaction time mean AUC	1.7	2.3	3.3	1.8	-1.6	-1.1	1.5
Median of all reaction times	1.1	1.5	2.5	1.1	-1.2	-0.8	1.6
Reaction time omissions	2.8	3.8	6.2	1.8	-2.5	-2.0	1.3
Reaction time false alarm rate	0.2	0.3	0.5	-0.6	0.6	0.7	-0.2
Reaction time premature initiation rate	1.0	1.3	3.2	-0.9	0.9	0.6	-1.8
Reaction time premature initiations	1.1	1.6	1.8	-1.3	1.4	1.1	-1.3
Std. dev. reaction times	2.1	3.0	6.1	2.5	-1.9	-1.5	0.5
Reaction time trials completed	0.8	1.1	1.6	-1.1	1.1	1.3	0.7
Reaction time trials AUC	0.8	1.1	1.5	-1.1	1.0	1.2	0.8
Run reversals in cocaine runway, females	0.4	0.4	0.8	0.1	-0.9	-0.8	0.4
Run reversals in cocaine runway, males	1.6	1.5	3.5	0.7	-1.3	-0.7	1.9
Latency to leave start box in cocaine runway	0.6	0.7	0.9	-0.8	0.9	0.9	-0.5
Latency to leave start box in cocaine runway, F	2.4	2.7	3.5	-1.6	1.9	1.8	-1.2
Latency to leave start box in cocaine runway, M	1.5	1.4	1.8	1.1	-1.3	-1.1	1.2
Std. dev. time between licks in bursts	0.4	0.4	0.9	-1.0	0.4	0.5	0.6
Total sessions with >9 infusions	0.6	0.7	2.3	-0.3	0.5	0.4	-1.5
Short access day 1 total inactive lever presses	0.3	0.4	1.2	0.5	0.1	-0.1	-1.1
Short access day 10 total inactive lever presses	1.7	1.9	3.3	1.8	-1.1	-1.6	-0.8
Short access day 1 total infusions	1.4	1.5	3.1	-1.3	1.0	0.7	-1.8
Short access day 10 total infusions	1.4	1.6	3.0	-0.6	1.3	1.2	-1.7
Short access total infusions	1.8	2.0	3.0	-1.0	1.5	1.3	-1.7
Short access day 1 locomotion	0.3	0.3	1.2	0.3	-0.0	-0.1	-1.1
Short access day 10 total locomotion	1.2	1.3	1.8	1.4	-1.4	-1.3	0.0
Short access total locomotion	0.3	0.3	0.8	0.3	0.4	0.4	-0.9
One hour access (0.3 mA shock)	4.1	4.8	7.0	-2.2	2.7	2.5	-1.2
Compulsive drug intake	1.6	1.6	2.1	1.4	-1.3	-1.4	0.9
One hour access (shock baseline)	6.1	7.1	9.5	-2.5	3.1	3.0	-2.0
Social response proportion	0.7	0.8	1.9	1.4	-0.8	-0.7	-0.2
Social responses	1.2	1.5	2.8	1.7	-1.3	-1.3	-0.1
Social time	0.1	0.1	0.3	0.3	0.3	0.5	0.2
Soleus weight	0.6	1.7	2.3	1.5	-1.4	-1.0	1.3
Bone: stiffness	0.3	0.5	1.2	-1.1	0.4	0.6	0.6
Tibialis anterior weight	4.5	15.4	24.2	2.9	-4.3	-3.3	4.9
Time to tail flick, vehicle, before self-admin	0.7	0.7	1.3	-1.0	1.1	0.7	-0.2
Time to tail flick, vehicle, after self-admin	1.8	1.9	2.9	-1.6	1.7	1.2	-0.8
Time to tail flick, test, before self-admin	0.8	0.8	1.0	1.0	-0.7	-0.9	-1.0
Time to tail flick, test, after self-admin	0.6	0.6	1.4	-0.6	0.6	0.5	-1.2
Delta time to tail flick, vehicle, before/after SA	0.9	0.9	1.3	-0.8	1.1	1.2	-0.5
Delta time to tail flick, test, before/after SA	0.2	0.1	0.3	-0.5	-0.1	-0.1	-0.6
Tibia length	0.8	2.1	3.1	-1.2	1.7	1.1	-1.8
Ambulatory time before self-admin	0.3	0.3	0.9	0.9	-0.2	-0.3	-0.2
Ambulatory time after self-admin	0.2	0.3	0.4	-0.0	0.5	0.6	-0.7
Bone: tissue strength	1.5	1.5	2.4	-0.8	1.3	1.1	-1.6
Total heroin consumption	0.2	0.2	0.7	0.2	0.0	0.3	0.8
Bone: trabecular number	1.0	1.5	2.5	-1.6	1.3	1.3	-0.3
Bone: trabecular spacing	1.7	2.2	3.3	1.8	-1.6	-1.6	0.2
Bone: trabecular thickness	3.4	4.1	7.3	-2.7	2.1	2.2	0.1
Bone: trabecular tissue density	2.0	2.9	4.3	1.7	-2.1	-1.9	0.5
Water consumed over 24 hours	0.0	0.0	0.1	0.0	-0.3	-0.1	0.3
Number of responses in last shaping day	0.2	0.2	0.5	0.4	-0.1	-0.1	-0.7