Hub : Genes

LOC103691443

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 OFC gene expression LOC103691443 0.13 0.07 7.9e-03 0.02 0.03 -0 0.01 1.0e-01 6.0e-02 4.4e-01 1.9e-01
2 Brain gene expression LOC103691443 0.04 0.02 2.6e-04 0.04 0.04 0.03 0.04 5.8e-05 2.2e-04 3.9e-04 1.2e-04
3 PL gene expression LOC103691443 0.05 0.03 1.9e-05 0.05 0.04 0.06 0.05 7.5e-06 1.5e-05 2.0e-07 4.1e-06

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bone: apparent density1.93.28.21.0-0.5-2.9
Area under the delay curve0.40.50.7-0.60.90.5
BMI with tail2.16.816.31.6-1.2-4.0
BMI without tail0.91.93.41.1-1.0-1.8
Body weight0.93.76.6-2.12.6-0.2
Weight adjusted by age1.01.21.8-0.51.21.4
Bone surface1.32.46.10.7-0.7-2.5
Bone volume2.03.37.81.2-0.9-2.8
Breakpoint value in progressive ratio session1.51.72.21.5-1.5-0.8
Number of licking bursts4.45.25.92.4-2.4-2.0
Context. condit. distance diff. score1.31.52.4-1.41.50.5
Locomotion velocity, session 10.40.41.2-0.20.21.1
Locomotion distance, session 10.10.20.4-0.30.40.6
Locomotion velocity, session 22.93.35.3-1.61.52.3
Locomotion distance, session 20.40.61.1-0.70.41.1
Locomotion velocity, session 33.84.55.0-2.22.12.0
Locomotion distance, session 35.25.76.3-2.52.22.4
Stereotopy head waving bouts, day 30.10.10.2-0.30.40.3
Stereotopy head waving duration, day 30.10.10.20.2-0.1-0.4
Locomotion velocity, session 71.51.61.9-1.41.21.3
Locomotion distance, session 71.92.43.2-1.71.80.9
Stereotopy head waving bouts, day 71.61.82.21.3-1.5-1.2
Stereotopy head waving duration, day 70.50.60.80.8-0.9-0.4
Locomotion velocity, session 81.72.12.8-1.21.71.4
Locomotion distance, session 82.03.04.0-2.01.91.1
Degree of sensitization distance0.80.81.60.9-0.3-1.2
Degree of sensitization stereotypy1.51.72.11.2-1.4-1.2
Conditioned locomotion0.20.30.80.2-0.3-0.9
Cocaine response after cond. corrected2.02.22.6-1.61.51.4
Cocaine response after cond. not corrected2.12.33.0-1.51.71.2
Cocaine response before conditioning0.10.20.40.10.7-0.2
Saline control response0.50.71.1-0.91.1-0.3
Bone: connectivity density0.91.44.1-0.10.3-2.0
Bone: cortical apparent density1.11.42.4-0.91.01.5
Bone: cortical area0.10.10.2-0.40.40.1
Bone: cortical porosity3.53.84.82.1-1.5-2.2
Bone: cortical porosity3.43.75.22.0-1.4-2.3
Bone: cortical thickness0.30.50.8-0.40.90.8
Bone: cortical thickness1.61.93.4-1.31.80.8
Bone: cortical tissue density1.11.42.3-0.91.11.5
Condit. Reinf. active minus inactive responses2.93.34.72.2-1.5-1.7
Condit. Reinf. active-inactive response ratio3.13.45.12.3-1.7-1.4
Condit. Reinf. active responses0.50.60.80.9-0.5-0.8
Condit. Reinf. inactive responses1.72.02.8-1.71.41.2
Incentive salience index mean3.44.16.22.5-1.8-1.6
Condit. Reinf. lever presses1.11.42.31.5-1.2-0.7
Condit. Reinf. active minus inactive responses1.72.13.0-1.31.31.7
Condit. Reinf. active-inactive response ratio1.21.21.5-1.01.11.2
Condit. Reinf. active responses0.30.40.9-0.50.30.9
Condit. Reinf. inactive responses0.00.00.1-0.0-0.3-0.2
Condit. Reinf. lever presses0.81.01.1-1.01.11.0
Condit. Reinf. lever reinforcers received0.60.81.5-0.80.61.2
Conditioned reinforcement - actives0.80.81.6-1.30.40.8
Conditioned reinforcement - inactives2.32.63.1-1.81.41.6
Conditioned locomotion1.72.02.4-1.51.11.6
Patch foraging indifference point 0 sec1.93.15.1-2.02.30.5
Patch foraging indifference point AUC1.31.51.71.3-1.3-1.1
Delay disc. indifference point, 0s delay0.10.10.20.30.10.4
Delay disc. indifference point, 16s delay0.20.30.5-0.40.70.4
Delay disc. indifference point, 2s delay0.40.40.7-0.50.50.9
Delay disc. indifference point, 24s delay0.10.10.20.4-0.20.5
Delay disc. indifference point, 4s delay0.70.81.2-0.51.10.9
Delay disc. indifference point, 8s delay0.10.10.2-0.40.40.2
Indifference point function ln k1.41.92.5-1.21.41.6
Indifference point function log k1.41.92.5-1.21.41.6
Patch foraging total patch changes 0 sec2.54.06.3-2.22.50.9
Patch foraging total patch changes 12 sec0.30.30.90.1-0.2-1.0
Patch foraging total patch changes 18 sec0.30.41.1-0.30.2-1.0
Patch foraging total patch changes 24 sec0.40.50.6-0.70.80.6
Patch foraging total patch changes 6 sec0.50.81.2-1.11.0-0.2
Patch foraging time to switch 0 sec2.84.45.51.9-2.0-2.3
Patch foraging water rate 0 sec1.72.83.7-1.51.51.9
Patch foraging water rate 12 sec1.92.93.2-1.81.81.5
Patch foraging water rate 18 sec2.94.05.1-1.91.72.3
Patch foraging water rate 24 sec2.33.14.1-2.01.22.0
Patch foraging water rate 6 sec8.712.613.4-3.43.73.6
Seeking ratio, delayed vs. immediate footshock2.32.64.40.8-1.7-2.1
Distance traveled before self-admin1.21.23.0-0.80.31.7
Distance traveled after self-admin1.21.31.7-0.91.11.3
Extensor digitorum longus weight2.07.911.52.9-3.4-2.0
Bone: elastic displacement0.20.20.50.7-0.00.2
Bone: elastic work0.40.50.91.0-0.3-0.6
Bone: endosteal estimation0.20.41.1-0.0-0.4-1.1
Bone: endosteal perimeter0.30.71.80.0-0.5-1.3
Epididymis fat weight0.20.40.6-0.70.7-0.3
Delta time in closed arm before/after self-admin7.27.09.32.4-2.4-3.1
Delta time in open arm before/after self-admin0.50.50.9-0.60.40.9
Diff in mean of infusions in LGA sessions0.50.60.60.8-0.80.7
Delay discount exponential model param0.60.60.90.7-1.0-0.7
Extinction: sum of active levers before priming0.60.61.60.4-1.3-0.2
Active lever presses in extinction session 60.70.61.20.7-1.1-0.5
Bone: final force0.10.20.3-0.40.5-0.3
Bone: final moment0.10.20.4-0.50.6-0.1
Food consumed during 24 hour testing period0.20.30.7-0.30.90.1
Glucose0.71.03.00.4-0.1-1.7
Heart weight0.50.81.70.7-1.3-0.5
Delay discount hyperbolic model param0.80.81.10.8-1.0-0.9
Intermittent access intake day 1-15 change0.50.50.9-0.50.7-0.9
Intermittent access intake escalation0.60.61.1-0.81.0-0.3
Intermittent access intake escalation 20.80.81.4-0.40.9-1.2
Intermitt. access day 1 inactive lever presses1.31.42.01.1-1.1-1.4
Intermitt. access day 15 inactive lever presses0.10.20.5-0.0-0.1-0.7
Intermitt. access escalation Index0.50.41.01.0-0.3-0.5
Intermittent access day 1 total infusions1.01.22.4-1.60.41.0
Intermittent access day 15 total infusions1.61.83.8-1.91.10.7
Intermittent access terminal intake (last 3 days)1.11.22.5-1.61.10.1
Intermittent access total infusions2.22.45.0-2.21.11.1
Intermittent access day 1 locomotion2.22.34.0-1.51.02.0
Intermittent access day 15 total locomotion3.33.54.1-1.91.72.0
Intermittent access total locomotion4.04.55.6-2.21.72.4
Intermittent access standard deviation0.30.31.0-0.10.2-1.0
Left kidney weight0.61.83.6-1.91.30.1
Right kidney weight0.51.43.3-1.81.0-0.0
Cocaine induced anxiety0.70.81.9-0.60.51.4
Post-drug Anxiety2.22.55.3-1.20.92.3
Baseline Anxiety0.60.71.80.40.01.3
Tail length4.814.621.3-3.63.14.6
Length with tail7.226.227.9-5.35.05.1
Length without tail4.59.812.4-3.53.52.2
Times rat made contact with spout0.50.61.50.5-0.3-1.2
Lifetime Intake2.42.75.4-2.31.11.2
Liver weight, left1.52.44.0-1.72.0-0.4
Liver weight, right0.71.22.8-0.50.8-1.7
Locomotor activity0.30.50.70.8-0.8-0.1
Locomotor testing distance1.01.72.61.6-1.6-0.3
Locomotor testing rearing0.40.60.80.9-0.9-0.2
Locomotion in novel chamber2.73.44.12.0-1.9-1.6
Locomotion in novel chamber post-restriction0.30.40.6-0.50.8-0.6
Fecal boli incidents, locomotor time 12.12.33.01.7-1.7-1.0
Change in fecal boli incidents, locomotor task0.30.30.9-1.00.10.2
Time >=10cm from walls, locomotor time 11.21.21.70.8-1.3-1.2
Bouts of movement, locomotor time 10.80.91.81.3-0.9-0.3
Total resting periods, locomotor time 10.60.71.31.2-0.9-0.1
Rest time, locomotor task time 11.82.03.81.4-2.00.1
Distance moved, locomotor task time 10.80.91.6-1.31.00.1
Vertical activity count, locomotor time 11.41.51.9-1.31.40.9
Time >=10cm from walls, locomotor time 21.31.43.00.6-0.9-1.7
Bouts of movement, locomotor time 20.40.41.3-0.0-0.31.1
Total resting periods, locomotor time 20.40.40.80.2-0.60.9
Rest time, locomotor task time 23.13.55.31.9-2.3-1.3
Distance moved, locomotor task time 21.21.42.4-1.51.10.8
Vertical activity count, locomotor time 21.31.41.8-1.31.31.0
Light reinforcement 10.81.52.3-0.81.21.5
Light reinforcement 21.01.31.91.4-1.4-0.3
Bone: marrow area0.20.51.40.1-0.5-1.2
Bone: maximum diameter0.50.92.00.5-0.7-1.4
Bone: maximum force0.10.20.40.3-0.0-0.6
Bone: maximum moment0.00.10.10.20.1-0.4
Mean time between licks in bursts0.30.51.01.0-0.40.5
Mean num. licks in bursts2.93.55.2-2.02.31.2
Cd content in liver0.20.20.3-0.50.50.1
Co content in liver0.91.12.0-0.90.51.4
Cu content in liver0.40.50.8-0.70.9-0.2
Fe content in liver1.61.92.9-1.61.70.1
K content in liver0.20.20.60.2-0.0-0.8
Mg content in liver0.20.20.5-0.1-0.2-0.7
Mn content in liver0.10.10.30.1-0.5-0.0
Na content in liver0.30.41.00.10.1-1.0
Rb content in liver0.70.91.2-0.81.11.0
Se content in liver0.40.51.30.6-1.1-0.1
Sr content in liver1.31.21.81.3-0.9-0.9
Zn content in liver0.50.60.9-0.50.7-1.0
Bone: minimum diameter1.01.83.0-1.71.30.7
Time in familiar zone, hab. session 14.64.35.6-2.42.11.7
Time in novel zone, hab. session 11.71.62.41.5-1.4-0.8
Total zone transitions, hab. session 10.10.10.40.1-0.2-0.6
Total locomotion distance, hab. session 10.20.30.50.4-0.3-0.7
Locomotion velocity, hab. session 10.50.71.50.6-0.5-1.2
Time in familiar zone, hab. session 23.03.13.6-1.91.61.8
Time in novel zone, hab. session 23.13.13.61.8-1.5-1.9
Total zone transitions, hab. session 20.00.00.10.0-0.2-0.2
Total locomotion distance, hab. session 20.81.11.21.0-1.1-1.0
Locomotion velocity, hab. session 20.50.70.80.7-0.9-0.8
Novel to familiar place preference ratio0.20.20.30.3-0.4-0.5
Novelty place preference0.10.10.20.1-0.1-0.4
Time in novel zone, NPP test0.10.10.30.0-0.0-0.6
Total zone transitions, NPP test0.30.40.6-0.60.80.5
Total locomotion distance, NPP test0.20.30.40.6-0.5-0.6
Locomotion velocity, NPP test0.00.00.00.10.00.2
Intraocular pressure1.72.44.81.3-2.2-0.8
Delta distance traveled before/after self-admin0.80.81.7-0.91.30.3
Delta ambulatory time before/after self-admin1.11.32.6-1.11.60.2
Parametrial fat weight0.20.50.9-0.21.0-0.7
Pavlov. Cond. lever latency0.30.30.8-0.40.40.9
Pavlov. Cond. magazine entry latency1.31.72.9-1.31.70.7
Pavlov. Cond. change in total contacts1.71.93.8-1.41.90.0
Pavlov. Cond. index score0.10.10.2-0.10.4-0.3
Pavlov. Cond. latency score0.20.20.50.20.0-0.7
Pavlov. Cond. lever contacts0.10.10.2-0.20.1-0.5
Pavlov. Cond. magazine entry number1.01.22.11.0-1.5-0.6
Pavlov. Cond. intertrial magazine entries1.92.32.91.3-1.5-1.7
Pavlov. Cond. lever-magazine prob. diff.0.10.10.3-0.20.5-0.2
Pavlov. Cond. response bias1.11.32.2-1.31.50.4
Pavlov. Cond. lever latency0.10.10.30.3-0.50.3
Pavlov. Cond. magazine entry latency0.10.10.1-0.40.3-0.2
Pavlov. Cond. change in total contacts0.81.21.6-0.91.01.3
Pavlov. Cond. index score0.20.30.5-0.60.70.3
Pavlov. Cond. latency score0.30.40.6-0.60.80.3
Pavlov. Cond. lever contacts0.20.30.4-0.60.7-0.1
Pavlov. Cond. magazine entry number0.10.20.20.4-0.5-0.2
Pavlov. Cond. intertrial magazine entries1.72.22.4-1.61.51.5
Pavlov. Cond. lever-magazine prob. diff.0.20.30.4-0.60.70.3
Pavlov. Cond. response bias0.10.10.2-0.50.3-0.2
Time in closed arm before self-admin0.40.50.9-0.40.90.7
Time in closed arm after self-admin1.01.01.91.4-0.8-0.7
Time in open arm before self-admin0.40.40.80.3-0.6-0.9
Time in open arm after self-admin0.10.10.2-0.4-0.4-0.0
Bone: periosteal estimation0.10.20.5-0.3-0.0-0.7
Bone: periosteal perimeter0.10.10.2-0.40.0-0.5
Bone: post-yield work0.20.30.80.30.0-0.9
Progressive ratio test 1 active lever presses0.70.71.8-1.30.6-0.2
Progressive ratio test 1 breakpoint0.50.51.0-1.00.5-0.4
Progressive ratio test 1 inactive lever presses0.80.91.7-1.30.70.7
Progressive ratio test 2 active lever presses0.40.41.1-1.10.2-0.4
Progressive ratio test 2 breakpoint0.50.61.2-1.10.2-0.7
Progressive ratio test 2 inactive lever presses1.41.62.8-1.71.20.8
Incentive Sensitization - Responses0.50.50.6-0.70.7-0.8
Incentive Sensitization - Breakpoint0.50.50.7-0.70.7-0.8
Sum of active levers in priming session hrs 5-60.70.70.91.0-0.80.7
Progressive ratio0.30.40.50.7-0.4-0.7
Food seeking constrained by brief footshock5.06.17.2-2.02.72.7
Seeking ratio, punishment vs. effort3.54.25.8-1.72.02.4
Retroperitoneal fat weight0.20.61.6-0.3-0.0-1.3
Reaction time number correct7.410.614.1-3.53.82.4
Reaction time mean minus median0.20.20.40.6-0.2-0.5
Reaction time mean minus median AUC0.00.00.1-0.00.3-0.2
Reaction time num false alarms0.70.92.00.4-0.8-1.4
Reaction time num false alarms AUC1.21.63.20.8-1.1-1.8
Reaction time trials correct on left7.410.614.1-3.53.82.4
Reaction time trials on left7.711.014.6-3.53.82.5
Reaction time mean0.91.32.21.5-1.3-0.4
Reaction time mean AUC0.60.81.51.2-0.9-0.2
Median of all reaction times1.21.62.61.6-1.5-0.2
Reaction time omissions1.31.82.3-1.11.51.3
Reaction time false alarm rate5.57.78.92.5-3.0-2.8
Reaction time premature initiation rate0.81.11.7-0.51.11.3
Reaction time premature initiations5.07.19.6-2.43.12.4
Std. dev. reaction times0.10.20.30.6-0.3-0.4
Reaction time trials completed7.711.014.6-3.53.82.5
Reaction time trials AUC6.89.813.3-3.33.62.3
Run reversals in cocaine runway, females1.21.22.70.8-0.4-1.6
Run reversals in cocaine runway, males0.20.20.30.0-0.5-0.5
Latency to leave start box in cocaine runway1.81.93.21.8-1.4-0.7
Latency to leave start box in cocaine runway, F1.11.21.21.1-1.1-1.1
Latency to leave start box in cocaine runway, M1.11.01.91.4-1.00.4
Std. dev. time between licks in bursts1.92.33.21.7-1.8-1.0
Total sessions with >9 infusions0.30.31.0-1.00.2-0.1
Short access day 1 total inactive lever presses1.71.93.4-1.80.81.3
Short access day 10 total inactive lever presses0.70.82.01.4-0.5-0.3
Short access day 1 total infusions1.21.22.2-1.50.90.9
Short access day 10 total infusions1.71.94.4-2.11.00.6
Short access total infusions1.61.83.5-1.90.91.1
Short access day 1 locomotion0.20.20.2-0.5-0.40.4
Short access day 10 total locomotion0.10.20.30.3-0.40.5
Short access total locomotion1.01.12.3-0.80.61.5
One hour access (0.3 mA shock)0.81.02.2-1.50.80.3
Compulsive drug intake1.81.82.01.3-1.4-1.3
One hour access (shock baseline)3.74.36.0-2.42.21.4
Social response proportion0.70.70.91.0-0.9-0.7
Social responses0.20.20.60.00.20.8
Social time0.50.61.7-0.20.21.3
Soleus weight0.10.40.50.6-0.7-0.6
Bone: stiffness0.10.20.50.2-0.1-0.7
Tibialis anterior weight1.44.75.72.1-2.4-2.0
Time to tail flick, vehicle, before self-admin6.36.515.0-1.51.53.9
Time to tail flick, vehicle, after self-admin0.30.40.7-0.30.80.6
Time to tail flick, test, before self-admin0.70.71.9-0.01.4-0.4
Time to tail flick, test, after self-admin0.10.10.20.00.4-0.2
Delta time to tail flick, vehicle, before/after SA4.03.98.81.5-0.9-3.0
Delta time to tail flick, test, before/after SA0.10.10.2-0.0-0.40.2
Tibia length3.18.714.3-3.03.81.7
Ambulatory time before self-admin0.40.41.0-0.2-0.31.0
Ambulatory time after self-admin1.01.11.4-0.91.11.2
Bone: tissue strength2.01.92.91.7-1.5-0.7
Total heroin consumption0.40.40.50.7-0.70.6
Bone: trabecular number0.61.02.4-0.30.6-1.5
Bone: trabecular spacing0.91.23.4-0.40.21.8
Bone: trabecular thickness3.33.99.01.3-1.0-3.0
Bone: trabecular tissue density2.43.44.22.1-2.1-1.3
Water consumed over 24 hours2.42.84.41.4-1.4-2.1
Number of responses in last shaping day0.50.61.4-0.5-0.2-1.2