LOC103691380

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC103691380 0.06 0.04 9.0e-04 0 0 0.01 0.01 1.2e-01 1.1e-01 9.4e-03 2.3e-02
2 Liver mRNA stability LOC103691380 0.44 0.12 0.0e+00 0.14 0.12 0.34 0.27 5.5e-15 2.5e-13 1.1e-38 2.2e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.72.95.0-2.20.8
Area under the delay curve1.21.52.0-1.40.9
BMI with tail4.114.225.5-5.1-1.7
BMI without tail2.47.311.9-3.4-1.6
Body weight4.820.839.2-6.3-1.5
Weight adjusted by age1.62.52.9-1.4-1.7
Bone surface0.50.81.7-1.30.0
Bone volume1.73.06.0-2.40.1
Breakpoint value in progressive ratio session1.92.22.9-1.71.3
Number of licking bursts1.21.92.8-1.71.0
Context. condit. distance diff. score1.21.51.71.3-1.1
Locomotion velocity, session 10.60.61.00.51.0
Locomotion distance, session 10.70.81.01.0-0.8
Locomotion velocity, session 22.83.33.61.9-1.7
Locomotion distance, session 20.50.71.0-1.0-0.7
Locomotion velocity, session 30.50.60.90.6-1.0
Locomotion distance, session 31.92.03.11.0-1.8
Stereotopy head waving bouts, day 30.10.10.1-0.30.3
Stereotopy head waving duration, day 30.40.51.0-0.01.0
Locomotion velocity, session 70.00.00.1-0.3-0.1
Locomotion distance, session 70.40.50.50.7-0.7
Stereotopy head waving bouts, day 70.10.10.2-0.40.2
Stereotopy head waving duration, day 70.60.71.2-1.10.4
Locomotion velocity, session 81.11.32.51.6-0.3
Locomotion distance, session 81.01.41.61.1-1.3
Degree of sensitization distance1.01.12.0-0.31.4
Degree of sensitization stereotypy0.40.50.7-0.80.5
Conditioned locomotion0.20.20.30.5-0.3
Cocaine response after cond. corrected1.31.62.71.6-0.7
Cocaine response after cond. not corrected1.61.93.51.9-0.4
Cocaine response before conditioning0.30.30.70.00.8
Saline control response0.81.01.91.4-0.4
Bone: connectivity density0.00.00.1-0.10.3
Bone: cortical apparent density6.08.29.93.1-2.5
Bone: cortical area4.77.214.4-3.8-0.1
Bone: cortical porosity0.50.50.6-0.60.8
Bone: cortical porosity1.41.51.8-1.31.1
Bone: cortical thickness1.62.74.6-2.2-0.9
Bone: cortical thickness1.11.31.8-0.9-1.3
Bone: cortical tissue density6.08.210.43.2-2.4
Condit. Reinf. active minus inactive responses0.10.10.1-0.10.4
Condit. Reinf. active-inactive response ratio0.10.10.10.20.3
Condit. Reinf. active responses0.60.70.9-1.00.7
Condit. Reinf. inactive responses1.11.42.0-1.40.8
Incentive salience index mean0.20.20.30.30.5
Condit. Reinf. lever presses0.20.30.50.40.7
Condit. Reinf. active minus inactive responses3.64.75.2-2.02.3
Condit. Reinf. active-inactive response ratio1.82.12.9-1.11.7
Condit. Reinf. active responses4.25.96.8-2.62.2
Condit. Reinf. inactive responses1.21.62.1-1.51.0
Condit. Reinf. lever presses2.23.03.4-1.81.6
Condit. Reinf. lever reinforcers received3.85.45.8-2.42.2
Conditioned reinforcement - actives0.30.60.7-0.70.8
Conditioned reinforcement - inactives0.60.91.3-1.10.7
Conditioned locomotion0.20.20.30.3-0.6
Patch foraging indifference point 0 sec1.12.04.0-2.0-0.2
Patch foraging indifference point AUC2.02.93.3-1.61.8
Delay disc. indifference point, 0s delay0.40.50.9-1.0-0.1
Delay disc. indifference point, 16s delay1.01.11.2-1.01.1
Delay disc. indifference point, 2s delay0.00.00.0-0.0-0.1
Delay disc. indifference point, 24s delay3.03.43.7-1.91.8
Delay disc. indifference point, 4s delay0.40.40.4-0.60.7
Delay disc. indifference point, 8s delay2.83.25.6-2.41.0
Indifference point function ln k0.50.90.91.0-0.9
Indifference point function log k0.50.90.91.0-0.9
Patch foraging total patch changes 0 sec1.22.34.7-2.20.0
Patch foraging total patch changes 12 sec1.52.03.0-1.71.0
Patch foraging total patch changes 18 sec3.85.88.5-2.91.8
Patch foraging total patch changes 24 sec3.05.26.5-2.62.0
Patch foraging total patch changes 6 sec2.64.07.8-2.80.4
Patch foraging time to switch 0 sec0.51.01.61.3-0.6
Patch foraging water rate 0 sec0.20.40.8-0.90.1
Patch foraging water rate 12 sec0.40.91.5-1.20.4
Patch foraging water rate 18 sec0.30.40.4-0.6-0.7
Patch foraging water rate 24 sec1.21.63.1-1.8-0.4
Patch foraging water rate 6 sec0.30.51.00.0-1.0
Seeking ratio, delayed vs. immediate footshock0.10.10.20.5-0.3
Distance traveled before self-admin3.84.95.22.2-2.3
Distance traveled after self-admin2.22.74.21.1-2.0
Extensor digitorum longus weight0.20.91.7-1.30.4
Bone: elastic displacement0.10.10.1-0.40.4
Bone: elastic work0.91.12.2-0.3-1.5
Bone: endosteal estimation1.53.36.6-2.60.3
Bone: endosteal perimeter2.24.79.0-3.0-0.6
Epididymis fat weight6.221.142.1-6.50.4
Delta time in closed arm before/after self-admin0.70.70.90.7-0.9
Delta time in open arm before/after self-admin2.02.02.7-1.61.2
Diff in mean of infusions in LGA sessions0.40.50.80.90.4
Delay discount exponential model param1.41.62.21.5-1.0
Extinction: sum of active levers before priming1.82.03.0-0.91.7
Active lever presses in extinction session 60.30.30.5-0.70.1
Bone: final force1.01.62.8-1.7-0.6
Bone: final moment1.32.03.8-1.9-0.5
Food consumed during 24 hour testing period0.20.30.50.3-0.7
Glucose0.81.32.5-0.3-1.6
Heart weight1.11.63.1-1.8-0.4
Delay discount hyperbolic model param1.01.11.71.3-0.7
Intermittent access intake day 1-15 change0.61.32.4-1.5-0.5
Intermittent access intake escalation0.61.22.4-1.6-0.3
Intermittent access intake escalation 20.60.71.2-1.1-0.4
Intermitt. access day 1 inactive lever presses1.14.06.2-2.51.3
Intermitt. access day 15 inactive lever presses0.30.50.7-0.80.6
Intermitt. access escalation Index0.10.10.20.2-0.5
Intermittent access day 1 total infusions0.71.11.5-1.20.8
Intermittent access day 15 total infusions0.81.22.2-1.50.5
Intermittent access terminal intake (last 3 days)0.40.51.0-1.00.3
Intermittent access total infusions1.21.42.3-1.50.7
Intermittent access day 1 locomotion0.20.30.60.1-0.8
Intermittent access day 15 total locomotion0.61.12.1-1.5-0.3
Intermittent access total locomotion0.60.71.4-0.1-1.2
Intermittent access standard deviation0.71.42.3-1.50.8
Left kidney weight1.15.08.8-1.1-3.0
Right kidney weight1.57.010.8-1.8-3.3
Cocaine induced anxiety2.02.95.32.3-0.7
Post-drug Anxiety0.00.00.10.30.0
Baseline Anxiety3.23.76.0-2.41.2
Tail length0.10.51.0-1.0-0.1
Length with tail0.73.05.7-2.4-0.6
Length without tail2.37.615.1-3.90.0
Times rat made contact with spout0.40.40.7-0.8-0.4
Lifetime Intake1.51.83.0-1.70.7
Liver weight, left2.94.79.3-3.0-0.4
Liver weight, right2.74.75.4-2.3-2.0
Locomotor activity0.91.42.80.1-1.7
Locomotor testing distance1.83.25.80.7-2.4
Locomotor testing rearing0.61.32.6-0.1-1.6
Locomotion in novel chamber2.22.83.81.4-2.0
Locomotion in novel chamber post-restriction0.71.22.31.5-0.3
Fecal boli incidents, locomotor time 10.10.10.2-0.10.5
Change in fecal boli incidents, locomotor task0.10.10.20.5-0.1
Time >=10cm from walls, locomotor time 10.60.61.11.00.3
Bouts of movement, locomotor time 13.33.75.1-2.31.5
Total resting periods, locomotor time 12.93.24.7-2.21.3
Rest time, locomotor task time 10.20.20.3-0.6-0.3
Distance moved, locomotor task time 10.00.00.00.2-0.0
Vertical activity count, locomotor time 11.02.33.11.8-1.2
Time >=10cm from walls, locomotor time 20.30.40.7-0.80.5
Bouts of movement, locomotor time 20.20.20.50.70.2
Total resting periods, locomotor time 20.00.10.10.30.2
Rest time, locomotor task time 20.40.60.80.6-0.9
Distance moved, locomotor task time 21.01.21.5-1.01.2
Vertical activity count, locomotor time 20.10.10.2-0.40.2
Light reinforcement 10.20.50.80.90.4
Light reinforcement 20.60.91.81.4-0.1
Bone: marrow area1.53.36.6-2.60.2
Bone: maximum diameter4.58.416.7-4.10.2
Bone: maximum force0.71.32.2-1.5-0.7
Bone: maximum moment0.91.63.0-1.7-0.5
Mean time between licks in bursts0.41.01.1-0.91.1
Mean num. licks in bursts1.21.82.61.0-1.6
Cd content in liver3.33.63.81.9-1.9
Co content in liver2.02.43.82.0-0.9
Cu content in liver0.20.20.30.5-0.3
Fe content in liver1.61.92.4-1.51.2
K content in liver0.20.20.30.60.4
Mg content in liver0.20.20.4-0.00.6
Mn content in liver0.10.10.20.5-0.1
Na content in liver0.30.40.60.30.8
Rb content in liver1.11.32.50.21.6
Se content in liver0.50.50.90.90.4
Sr content in liver2.42.13.51.9-0.8
Zn content in liver0.91.01.81.3-0.5
Bone: minimum diameter2.85.110.2-3.20.3
Time in familiar zone, hab. session 11.91.82.31.5-1.2
Time in novel zone, hab. session 12.62.63.8-1.91.2
Total zone transitions, hab. session 10.60.81.0-0.8-1.0
Total locomotion distance, hab. session 10.10.20.3-0.60.3
Locomotion velocity, hab. session 10.10.10.2-0.40.3
Time in familiar zone, hab. session 24.64.97.2-2.71.6
Time in novel zone, hab. session 23.13.13.81.9-1.6
Total zone transitions, hab. session 20.81.01.4-1.2-0.8
Total locomotion distance, hab. session 20.40.61.0-1.0-0.3
Locomotion velocity, hab. session 20.20.30.5-0.7-0.4
Novel to familiar place preference ratio0.30.30.4-0.50.6
Novelty place preference0.40.40.4-0.70.6
Time in novel zone, NPP test1.11.21.6-1.20.9
Total zone transitions, NPP test1.01.42.8-1.7-0.2
Total locomotion distance, NPP test0.91.22.4-1.50.2
Locomotion velocity, NPP test0.20.30.6-0.8-0.2
Intraocular pressure3.14.48.1-2.80.9
Delta distance traveled before/after self-admin0.50.51.0-1.0-0.2
Delta ambulatory time before/after self-admin1.31.62.8-1.70.6
Parametrial fat weight7.818.335.3-5.91.2
Pavlov. Cond. lever latency0.50.71.0-1.00.5
Pavlov. Cond. magazine entry latency0.10.10.3-0.5-0.0
Pavlov. Cond. change in total contacts0.40.40.50.5-0.7
Pavlov. Cond. index score0.20.20.40.1-0.7
Pavlov. Cond. latency score0.20.20.40.3-0.6
Pavlov. Cond. lever contacts0.40.40.80.9-0.3
Pavlov. Cond. magazine entry number0.40.50.70.50.9
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.50.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.20.1-0.5
Pavlov. Cond. response bias0.20.20.30.4-0.5
Pavlov. Cond. lever latency2.94.04.31.9-2.1
Pavlov. Cond. magazine entry latency1.61.93.3-1.80.7
Pavlov. Cond. change in total contacts3.04.95.3-2.32.1
Pavlov. Cond. index score3.04.15.5-2.31.6
Pavlov. Cond. latency score3.03.95.4-2.31.6
Pavlov. Cond. lever contacts1.92.62.8-1.71.5
Pavlov. Cond. magazine entry number1.62.03.31.8-0.8
Pavlov. Cond. intertrial magazine entries0.10.10.2-0.1-0.4
Pavlov. Cond. lever-magazine prob. diff.2.63.54.9-2.21.4
Pavlov. Cond. response bias2.63.54.2-2.11.7
Time in closed arm before self-admin0.10.10.10.3-0.3
Time in closed arm after self-admin0.60.71.01.0-0.6
Time in open arm before self-admin0.50.51.01.00.3
Time in open arm after self-admin1.41.51.9-1.01.4
Bone: periosteal estimation3.47.214.5-3.8-0.2
Bone: periosteal perimeter4.78.216.2-4.0-0.4
Bone: post-yield work0.91.41.4-1.11.2
Progressive ratio test 1 active lever presses1.92.33.6-1.91.0
Progressive ratio test 1 breakpoint1.82.33.5-1.91.0
Progressive ratio test 1 inactive lever presses2.02.83.7-1.91.4
Progressive ratio test 2 active lever presses1.72.03.8-1.90.5
Progressive ratio test 2 breakpoint1.82.03.8-2.00.5
Progressive ratio test 2 inactive lever presses1.52.44.0-2.00.9
Incentive Sensitization - Responses0.71.02.0-1.40.3
Incentive Sensitization - Breakpoint0.70.91.7-1.30.3
Sum of active levers in priming session hrs 5-60.40.30.60.30.8
Progressive ratio0.30.40.80.20.9
Food seeking constrained by brief footshock1.51.93.1-0.81.8
Seeking ratio, punishment vs. effort0.10.20.3-0.6-0.1
Retroperitoneal fat weight7.030.059.5-7.70.7
Reaction time number correct0.81.62.9-1.70.5
Reaction time mean minus median0.10.20.4-0.6-0.1
Reaction time mean minus median AUC0.20.40.8-0.2-0.9
Reaction time num false alarms0.10.10.2-0.20.4
Reaction time num false alarms AUC0.00.00.00.00.1
Reaction time trials correct on left0.81.62.9-1.70.5
Reaction time trials on left0.91.63.0-1.70.5
Reaction time mean0.60.91.20.8-1.1
Reaction time mean AUC0.50.91.01.0-0.8
Median of all reaction times1.31.82.11.2-1.4
Reaction time omissions0.20.30.5-0.70.2
Reaction time false alarm rate0.20.20.40.60.1
Reaction time premature initiation rate0.91.32.30.6-1.5
Reaction time premature initiations0.61.01.9-0.3-1.4
Std. dev. reaction times0.20.40.6-0.8-0.5
Reaction time trials completed0.91.63.0-1.70.5
Reaction time trials AUC0.91.73.2-1.80.5
Run reversals in cocaine runway, females0.50.50.9-0.2-1.0
Run reversals in cocaine runway, males0.30.30.60.30.8
Latency to leave start box in cocaine runway0.70.81.41.2-0.4
Latency to leave start box in cocaine runway, F1.11.32.31.5-0.5
Latency to leave start box in cocaine runway, M0.10.10.1-0.30.0
Std. dev. time between licks in bursts1.82.53.4-1.31.8
Total sessions with >9 infusions1.21.42.8-1.7-0.1
Short access day 1 total inactive lever presses1.21.62.6-1.60.8
Short access day 10 total inactive lever presses0.10.30.6-0.8-0.3
Short access day 1 total infusions0.40.50.9-1.00.1
Short access day 10 total infusions0.30.40.4-0.70.6
Short access total infusions0.60.81.5-1.20.4
Short access day 1 locomotion0.81.01.6-1.30.6
Short access day 10 total locomotion0.91.63.10.2-1.8
Short access total locomotion0.50.61.1-0.3-1.0
One hour access (0.3 mA shock)6.27.18.7-2.92.3
Compulsive drug intake1.72.02.5-1.21.6
One hour access (shock baseline)0.40.61.3-1.10.2
Social response proportion2.22.55.0-0.2-2.2
Social responses2.63.36.7-2.60.2
Social time0.50.71.2-0.4-1.1
Soleus weight1.44.16.2-1.4-2.5
Bone: stiffness0.30.40.6-0.5-0.8
Tibialis anterior weight0.31.01.7-0.61.3
Time to tail flick, vehicle, before self-admin0.10.10.1-0.3-0.3
Time to tail flick, vehicle, after self-admin0.10.10.20.40.3
Time to tail flick, test, before self-admin1.81.92.90.9-1.7
Time to tail flick, test, after self-admin0.80.91.4-1.20.6
Delta time to tail flick, vehicle, before/after SA0.60.60.9-0.41.0
Delta time to tail flick, test, before/after SA0.70.70.7-0.90.8
Tibia length0.82.23.5-0.9-1.9
Ambulatory time before self-admin2.84.26.01.5-2.5
Ambulatory time after self-admin2.22.64.60.8-2.2
Bone: tissue strength0.10.10.30.20.5
Total heroin consumption2.02.44.4-2.10.6
Bone: trabecular number0.91.51.8-1.31.1
Bone: trabecular spacing0.00.10.10.30.2
Bone: trabecular thickness3.74.68.8-3.00.7
Bone: trabecular tissue density0.60.91.30.6-1.2
Water consumed over 24 hours0.71.02.00.1-1.4
Number of responses in last shaping day0.10.10.2-0.40.3