LOC103691380

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose gene expression LOC103691380 0.06 0.04 9.0e-04 0 0 0.01 0.01 1.2e-01 1.1e-01 9.4e-03 2.1e-02
2 Liver mRNA stability LOC103691380 0.44 0.12 0.0e+00 0.14 0.12 0.34 0.27 5.5e-15 2.5e-13 1.1e-38 2.1e-30

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density1.62.95.02.2-0.8
Area under the delay curve0.91.52.01.4-0.9
BMI with tail4.114.225.55.11.7
BMI without tail1.47.311.93.41.6
Body weight4.820.839.26.31.6
Weight adjusted by age0.82.53.01.41.7
Bone surface0.40.81.71.3-0.0
Bone volume1.53.06.02.4-0.1
Breakpoint value in progressive ratio session1.22.22.91.7-1.3
Number of licking bursts0.61.92.81.7-1.0
Context. condit. distance diff. score1.21.51.7-1.31.1
Locomotion velocity, session 10.60.61.0-0.5-1.0
Locomotion distance, session 10.70.81.0-1.00.8
Locomotion velocity, session 22.83.33.6-1.91.7
Locomotion distance, session 20.50.71.01.00.6
Locomotion velocity, session 30.50.60.9-0.61.0
Locomotion distance, session 31.82.03.1-1.01.8
Stereotopy head waving bouts, day 30.10.10.10.3-0.3
Stereotopy head waving duration, day 30.40.51.00.0-1.0
Locomotion velocity, session 70.00.00.10.30.1
Locomotion distance, session 70.40.50.5-0.70.7
Stereotopy head waving bouts, day 70.10.10.20.4-0.2
Stereotopy head waving duration, day 70.60.71.21.1-0.4
Locomotion velocity, session 81.11.32.5-1.60.3
Locomotion distance, session 81.01.41.6-1.11.3
Degree of sensitization distance1.01.12.00.3-1.4
Degree of sensitization stereotypy0.40.50.70.8-0.5
Conditioned locomotion0.20.20.3-0.50.3
Cocaine response after cond. corrected1.11.62.7-1.60.7
Cocaine response after cond. not corrected1.31.83.5-1.90.4
Cocaine response before conditioning0.30.30.7-0.0-0.8
Saline control response0.71.01.9-1.40.4
Bone: connectivity density0.00.00.10.1-0.3
Bone: cortical apparent density5.28.29.9-3.12.5
Bone: cortical area4.47.214.43.80.2
Bone: cortical porosity0.50.50.60.6-0.8
Bone: cortical porosity1.31.51.81.3-1.1
Bone: cortical thickness1.62.74.62.20.9
Bone: cortical thickness1.01.31.80.91.3
Bone: cortical tissue density5.28.210.4-3.22.4
Condit. Reinf. active minus inactive responses0.10.10.10.1-0.4
Condit. Reinf. active-inactive response ratio0.10.10.1-0.2-0.3
Condit. Reinf. active responses0.50.70.91.0-0.7
Condit. Reinf. inactive responses1.11.42.01.4-0.8
Incentive salience index mean0.20.20.3-0.3-0.5
Condit. Reinf. lever presses0.20.30.5-0.4-0.7
Condit. Reinf. active minus inactive responses3.04.75.22.0-2.3
Condit. Reinf. active-inactive response ratio1.32.12.91.1-1.7
Condit. Reinf. active responses4.15.96.82.6-2.2
Condit. Reinf. inactive responses1.01.52.11.5-1.0
Condit. Reinf. lever presses2.13.03.41.8-1.6
Condit. Reinf. lever reinforcers received3.85.45.82.4-2.2
Conditioned reinforcement - actives0.10.60.70.7-0.9
Conditioned reinforcement - inactives0.30.91.31.1-0.7
Conditioned locomotion0.10.20.3-0.30.6
Patch foraging indifference point 0 sec0.72.04.02.00.2
Patch foraging indifference point AUC1.22.93.31.6-1.8
Delay disc. indifference point, 0s delay0.40.50.91.00.1
Delay disc. indifference point, 16s delay0.81.11.21.0-1.1
Delay disc. indifference point, 2s delay0.00.00.00.00.1
Delay disc. indifference point, 24s delay2.13.43.71.9-1.8
Delay disc. indifference point, 4s delay0.40.40.40.6-0.7
Delay disc. indifference point, 8s delay1.93.25.62.4-1.0
Indifference point function ln k0.30.90.9-1.00.9
Indifference point function log k0.30.90.9-1.00.9
Patch foraging total patch changes 0 sec0.82.34.72.2-0.0
Patch foraging total patch changes 12 sec1.52.03.01.7-1.0
Patch foraging total patch changes 18 sec2.55.88.52.9-1.8
Patch foraging total patch changes 24 sec1.55.26.52.6-2.0
Patch foraging total patch changes 6 sec2.44.07.82.8-0.4
Patch foraging time to switch 0 sec0.31.01.6-1.30.6
Patch foraging water rate 0 sec0.10.40.80.9-0.1
Patch foraging water rate 12 sec0.20.91.51.2-0.4
Patch foraging water rate 18 sec0.20.40.40.60.7
Patch foraging water rate 24 sec1.11.63.11.80.4
Patch foraging water rate 6 sec0.30.51.0-0.01.0
Seeking ratio, delayed vs. immediate footshock0.10.10.2-0.50.2
Distance traveled before self-admin2.34.95.2-2.22.3
Distance traveled after self-admin1.52.74.2-1.12.0
Extensor digitorum longus weight0.20.91.71.3-0.4
Bone: elastic displacement0.10.10.10.4-0.4
Bone: elastic work0.91.12.20.31.5
Bone: endosteal estimation1.43.36.62.6-0.3
Bone: endosteal perimeter1.94.79.03.00.6
Epididymis fat weight4.221.142.16.5-0.4
Delta time in closed arm before/after self-admin0.70.70.9-0.70.9
Delta time in open arm before/after self-admin1.72.02.71.6-1.2
Diff in mean of infusions in LGA sessions0.30.50.8-0.9-0.4
Delay discount exponential model param1.21.62.2-1.51.0
Extinction: sum of active levers before priming1.32.03.10.9-1.8
Active lever presses in extinction session 60.30.30.50.7-0.1
Bone: final force1.01.62.81.70.6
Bone: final moment1.32.03.81.90.5
Food consumed during 24 hour testing period0.10.30.5-0.30.7
Glucose0.81.32.60.31.6
Heart weight1.01.63.11.80.4
Delay discount hyperbolic model param0.91.11.7-1.30.7
Intermittent access intake day 1-15 change0.21.32.41.50.5
Intermittent access intake escalation0.21.22.41.60.3
Intermittent access intake escalation 20.40.71.21.10.4
Intermitt. access day 1 inactive lever presses0.34.06.22.5-1.3
Intermitt. access day 15 inactive lever presses0.10.50.70.8-0.6
Intermitt. access escalation Index0.00.10.2-0.20.5
Intermittent access day 1 total infusions0.41.11.51.2-0.8
Intermittent access day 15 total infusions0.51.22.21.5-0.5
Intermittent access terminal intake (last 3 days)0.30.51.01.0-0.3
Intermittent access total infusions1.21.42.31.5-0.7
Intermittent access day 1 locomotion0.20.30.6-0.10.8
Intermittent access day 15 total locomotion0.31.12.11.50.3
Intermittent access total locomotion0.60.71.40.11.2
Intermittent access standard deviation0.31.42.31.5-0.8
Left kidney weight0.65.18.81.13.0
Right kidney weight1.07.010.81.83.3
Cocaine induced anxiety1.12.95.3-2.30.7
Post-drug Anxiety0.00.00.1-0.3-0.0
Baseline Anxiety2.23.76.02.4-1.2
Tail length0.10.51.01.00.1
Length with tail0.73.05.72.40.6
Length without tail1.47.615.13.90.0
Times rat made contact with spout0.40.40.70.80.4
Lifetime Intake1.41.83.01.7-0.7
Liver weight, left2.74.79.33.00.4
Liver weight, right2.74.75.42.32.0
Locomotor activity0.91.42.8-0.11.7
Locomotor testing distance1.33.25.9-0.72.4
Locomotor testing rearing0.41.32.60.11.6
Locomotion in novel chamber2.12.83.8-1.42.0
Locomotion in novel chamber post-restriction0.41.22.3-1.50.3
Fecal boli incidents, locomotor time 10.00.10.20.1-0.5
Change in fecal boli incidents, locomotor task0.10.10.2-0.50.1
Time >=10cm from walls, locomotor time 10.50.61.1-1.0-0.3
Bouts of movement, locomotor time 12.93.75.12.3-1.5
Total resting periods, locomotor time 12.83.24.72.2-1.3
Rest time, locomotor task time 10.10.20.30.60.2
Distance moved, locomotor task time 10.00.00.0-0.20.0
Vertical activity count, locomotor time 10.32.33.1-1.81.2
Time >=10cm from walls, locomotor time 20.20.40.70.8-0.5
Bouts of movement, locomotor time 20.10.20.5-0.7-0.2
Total resting periods, locomotor time 20.00.10.1-0.3-0.2
Rest time, locomotor task time 20.30.60.8-0.60.9
Distance moved, locomotor task time 20.91.21.51.0-1.2
Vertical activity count, locomotor time 20.00.10.20.4-0.2
Light reinforcement 10.10.50.8-0.9-0.4
Light reinforcement 20.40.91.8-1.40.1
Bone: marrow area1.43.36.62.6-0.2
Bone: maximum diameter4.28.416.74.1-0.2
Bone: maximum force0.71.32.21.50.7
Bone: maximum moment0.91.63.01.70.5
Mean time between licks in bursts0.21.01.10.9-1.1
Mean num. licks in bursts0.71.82.6-1.01.6
Cd content in liver3.33.63.8-1.91.9
Co content in liver2.02.43.8-2.00.9
Cu content in liver0.20.20.3-0.50.3
Fe content in liver1.61.92.41.5-1.2
K content in liver0.20.20.3-0.6-0.4
Mg content in liver0.20.20.40.0-0.6
Mn content in liver0.10.10.2-0.50.1
Na content in liver0.30.40.6-0.3-0.8
Rb content in liver1.11.32.5-0.2-1.6
Se content in liver0.50.50.9-0.9-0.4
Sr content in liver2.42.13.5-1.90.8
Zn content in liver0.91.01.8-1.30.5
Bone: minimum diameter2.75.110.23.2-0.3
Time in familiar zone, hab. session 11.71.82.3-1.51.2
Time in novel zone, hab. session 12.32.63.81.9-1.2
Total zone transitions, hab. session 10.60.81.00.81.0
Total locomotion distance, hab. session 10.10.20.30.6-0.3
Locomotion velocity, hab. session 10.10.10.20.4-0.3
Time in familiar zone, hab. session 24.34.97.22.7-1.6
Time in novel zone, hab. session 22.93.13.8-1.91.6
Total zone transitions, hab. session 20.81.01.41.20.8
Total locomotion distance, hab. session 20.40.61.01.00.3
Locomotion velocity, hab. session 20.20.30.50.70.4
Novel to familiar place preference ratio0.20.30.40.5-0.6
Novelty place preference0.30.40.40.7-0.6
Time in novel zone, NPP test1.01.21.61.2-0.9
Total zone transitions, NPP test0.91.42.81.70.2
Total locomotion distance, NPP test0.91.22.41.5-0.2
Locomotion velocity, NPP test0.20.30.60.80.2
Intraocular pressure2.74.48.12.8-0.9
Delta distance traveled before/after self-admin0.50.51.01.00.2
Delta ambulatory time before/after self-admin0.91.62.81.7-0.6
Parametrial fat weight7.818.335.35.9-1.1
Pavlov. Cond. lever latency0.50.71.01.0-0.5
Pavlov. Cond. magazine entry latency0.10.10.30.50.0
Pavlov. Cond. change in total contacts0.40.40.5-0.50.7
Pavlov. Cond. index score0.20.20.4-0.10.7
Pavlov. Cond. latency score0.20.20.4-0.30.6
Pavlov. Cond. lever contacts0.40.40.8-0.90.3
Pavlov. Cond. magazine entry number0.40.50.7-0.5-0.9
Pavlov. Cond. intertrial magazine entries0.10.10.20.5-0.1
Pavlov. Cond. lever-magazine prob. diff.0.10.10.2-0.10.5
Pavlov. Cond. response bias0.20.20.3-0.40.5
Pavlov. Cond. lever latency2.84.04.3-1.92.1
Pavlov. Cond. magazine entry latency1.41.93.31.8-0.7
Pavlov. Cond. change in total contacts2.04.95.32.3-2.1
Pavlov. Cond. index score2.64.15.52.3-1.6
Pavlov. Cond. latency score2.43.95.42.3-1.6
Pavlov. Cond. lever contacts1.72.62.81.7-1.5
Pavlov. Cond. magazine entry number1.52.03.3-1.80.8
Pavlov. Cond. intertrial magazine entries0.00.10.20.10.4
Pavlov. Cond. lever-magazine prob. diff.2.33.54.92.2-1.4
Pavlov. Cond. response bias2.53.54.22.1-1.7
Time in closed arm before self-admin0.10.10.1-0.30.3
Time in closed arm after self-admin0.60.71.0-1.00.6
Time in open arm before self-admin0.40.51.0-1.0-0.3
Time in open arm after self-admin1.41.51.91.0-1.4
Bone: periosteal estimation3.07.214.53.80.2
Bone: periosteal perimeter4.18.216.24.00.4
Bone: post-yield work0.81.41.41.1-1.2
Progressive ratio test 1 active lever presses1.32.33.61.9-1.0
Progressive ratio test 1 breakpoint1.32.33.51.9-1.0
Progressive ratio test 1 inactive lever presses1.12.83.71.9-1.4
Progressive ratio test 2 active lever presses1.42.03.81.9-0.5
Progressive ratio test 2 breakpoint1.62.03.82.0-0.5
Progressive ratio test 2 inactive lever presses0.82.44.02.0-0.9
Incentive Sensitization - Responses0.41.02.01.4-0.3
Incentive Sensitization - Breakpoint0.40.91.71.3-0.3
Sum of active levers in priming session hrs 5-60.40.30.6-0.3-0.8
Progressive ratio0.10.40.8-0.2-0.9
Food seeking constrained by brief footshock1.51.93.10.8-1.8
Seeking ratio, punishment vs. effort0.10.20.30.60.1
Retroperitoneal fat weight6.730.059.57.7-0.7
Reaction time number correct0.41.62.91.7-0.5
Reaction time mean minus median0.00.20.40.60.0
Reaction time mean minus median AUC0.10.40.80.20.9
Reaction time num false alarms0.10.10.20.2-0.4
Reaction time num false alarms AUC0.00.00.0-0.0-0.1
Reaction time trials correct on left0.41.62.91.7-0.5
Reaction time trials on left0.51.63.01.7-0.5
Reaction time mean0.40.91.2-0.81.1
Reaction time mean AUC0.40.91.0-1.00.8
Median of all reaction times1.21.82.1-1.21.4
Reaction time omissions0.20.30.50.7-0.2
Reaction time false alarm rate0.20.20.4-0.6-0.1
Reaction time premature initiation rate0.81.32.3-0.61.5
Reaction time premature initiations0.31.01.90.31.4
Std. dev. reaction times0.10.40.60.80.5
Reaction time trials completed0.51.63.01.7-0.5
Reaction time trials AUC0.51.73.21.8-0.5
Run reversals in cocaine runway, females0.40.50.90.21.0
Run reversals in cocaine runway, males0.30.30.6-0.3-0.8
Latency to leave start box in cocaine runway0.60.81.4-1.20.4
Latency to leave start box in cocaine runway, F1.01.32.3-1.50.5
Latency to leave start box in cocaine runway, M0.10.10.10.3-0.0
Std. dev. time between licks in bursts1.32.53.41.3-1.8
Total sessions with >9 infusions1.11.42.81.70.1
Short access day 1 total inactive lever presses0.81.62.61.6-0.8
Short access day 10 total inactive lever presses0.00.30.60.80.3
Short access day 1 total infusions0.20.50.91.0-0.1
Short access day 10 total infusions0.20.40.40.7-0.6
Short access total infusions0.60.81.51.2-0.4
Short access day 1 locomotion0.61.01.61.3-0.6
Short access day 10 total locomotion0.41.63.1-0.21.8
Short access total locomotion0.40.61.10.31.0
One hour access (0.3 mA shock)6.07.18.72.9-2.3
Compulsive drug intake1.42.02.51.2-1.6
One hour access (shock baseline)0.20.61.31.1-0.2
Social response proportion2.02.55.00.22.2
Social responses2.53.36.72.6-0.2
Social time0.40.71.20.41.1
Soleus weight1.44.16.21.42.5
Bone: stiffness0.20.40.60.50.8
Tibialis anterior weight0.31.01.70.6-1.3
Time to tail flick, vehicle, before self-admin0.10.10.10.30.3
Time to tail flick, vehicle, after self-admin0.10.10.2-0.4-0.3
Time to tail flick, test, before self-admin1.61.92.9-0.91.7
Time to tail flick, test, after self-admin0.80.91.41.2-0.6
Delta time to tail flick, vehicle, before/after SA0.50.60.90.4-1.0
Delta time to tail flick, test, before/after SA0.60.70.70.9-0.8
Tibia length0.82.23.50.91.9
Ambulatory time before self-admin1.44.26.0-1.52.5
Ambulatory time after self-admin1.62.64.6-0.82.2
Bone: tissue strength0.10.10.3-0.2-0.5
Total heroin consumption2.02.34.42.1-0.6
Bone: trabecular number0.81.41.81.3-1.1
Bone: trabecular spacing0.00.10.1-0.3-0.2
Bone: trabecular thickness3.34.68.83.0-0.7
Bone: trabecular tissue density0.50.91.3-0.61.2
Water consumed over 24 hours0.51.02.0-0.11.4
Number of responses in last shaping day0.10.10.20.4-0.3