LOC103691375

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr1_252427268_252428720	0.07	0.04	1.3e-06	0.02	0.05	0.04	0.04	9.5e-04	3.4e-06	2.0e-05	1.8e-05
2	Liver	mRNA stability	LOC103691375	0.53	0.14	0.0e+00	0.26	0.31	0.31	0.32	5.8e-29	1.8e-35	3.8e-35	1.1e-35
3	Liver	isoform ratio	XR_005499738.1	0.41	0.11	0.0e+00	0.44	0.43	0.41	0.42	1.1e-52	1.9e-51	1.8e-49	1.2e-50
4	Liver	isoform ratio	XR_590723.3	0.42	0.11	0.0e+00	0.46	0.45	0.44	0.45	1.6e-56	1.3e-55	2.2e-54	8.4e-55
5	Liver	intron excision ratio	chr1_252425237_252427150	0.06	0.04	3.9e-06	0.05	0.04	0.04	0.04	4.0e-06	2.3e-05	8.8e-05	1.8e-05
6	Liver	gene expression	LOC103691375	0.4	0.14	0.0e+00	0.2	0.22	0.24	0.22	8.0e-22	8.2e-24	5.8e-26	8.6e-24

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	1.3	2.2	3.9	2.0	1.4	1.6	-1.6	-1.6	-0.2
Area under the delay curve	1.7	1.8	3.2	1.8	1.3	1.4	-1.4	-1.4	-0.2
BMI with tail	0.9	2.8	10.3	1.7	3.2	0.6	-0.6	-0.6	-1.6
BMI without tail	1.6	3.4	7.0	2.5	2.7	1.5	-1.4	-1.4	-0.9
Body weight	1.3	5.4	16.2	2.6	4.0	1.3	-1.3	-1.3	-2.0
Weight adjusted by age	0.2	0.2	0.6	0.7	0.8	0.4	-0.3	-0.3	0.2
Bone surface	0.1	0.1	0.3	0.4	0.5	0.2	-0.2	-0.2	-0.3
Bone volume	0.8	1.3	2.2	1.5	1.3	1.2	-1.1	-1.1	-0.4
Breakpoint value in progressive ratio session	1.1	1.2	1.8	1.4	0.6	1.2	-1.2	-1.2	0.5
Number of licking bursts	0.7	0.9	1.3	0.9	0.1	1.1	-1.1	-1.1	0.9
Context. condit. distance diff. score	0.7	0.8	1.4	-1.2	-1.1	-0.8	0.8	0.8	0.6
Locomotion velocity, session 1	1.2	1.2	2.7	0.3	-1.4	0.9	-1.0	-1.0	1.6
Locomotion distance, session 1	0.4	0.5	1.0	-1.0	-0.8	-0.7	0.7	0.7	-0.1
Locomotion velocity, session 2	1.4	1.6	2.6	-1.6	-0.5	-1.4	1.5	1.5	-0.6
Locomotion distance, session 2	0.1	0.2	0.6	-0.5	-0.8	0.0	-0.0	-0.0	0.6
Locomotion velocity, session 3	0.5	0.6	1.8	-0.9	-1.3	-0.2	0.2	0.2	0.9
Locomotion distance, session 3	0.9	1.0	3.5	-1.0	-1.9	0.0	-0.0	-0.0	1.2
Stereotopy head waving bouts, day 3	0.1	0.1	0.1	-0.2	-0.0	-0.4	0.4	0.4	-0.3
Stereotopy head waving duration, day 3	0.0	0.0	0.0	-0.0	-0.2	-0.2	0.2	0.2	0.1
Locomotion velocity, session 7	0.7	0.8	2.0	0.1	-1.1	0.7	-0.7	-0.7	1.4
Locomotion distance, session 7	0.8	1.0	2.5	-1.3	-1.6	-0.6	0.6	0.6	0.8
Stereotopy head waving bouts, day 7	0.3	0.3	0.9	-0.1	-1.0	0.3	-0.3	-0.3	0.9
Stereotopy head waving duration, day 7	0.4	0.5	1.0	0.4	-0.7	0.7	-0.7	-0.7	1.0
Locomotion velocity, session 8	0.2	0.3	0.5	-0.7	-0.4	-0.5	0.5	0.5	0.2
Locomotion distance, session 8	0.6	0.9	1.9	-1.4	-1.2	-0.8	0.8	0.8	0.6
Degree of sensitization distance	0.1	0.1	0.2	0.4	0.3	0.1	-0.1	-0.1	0.1
Degree of sensitization stereotypy	0.7	0.8	2.2	-0.3	-1.5	0.4	-0.4	-0.4	1.4
Conditioned locomotion	0.8	0.9	2.3	-1.3	-1.5	-0.4	0.5	0.5	1.0
Cocaine response after cond. corrected	1.2	1.3	2.0	-1.4	-0.8	-1.2	1.4	1.4	-0.3
Cocaine response after cond. not corrected	2.1	2.3	3.9	-2.0	-1.2	-1.6	1.7	1.7	0.1
Cocaine response before conditioning	0.2	0.3	0.7	-0.6	-0.6	-0.4	0.4	0.4	0.8
Saline control response	0.7	0.9	1.5	-1.2	-1.2	-0.9	0.9	0.9	0.1
Bone: connectivity density	0.2	0.3	0.8	0.7	0.9	0.4	-0.4	-0.4	-0.5
Bone: cortical apparent density	1.8	2.4	4.0	-2.0	-1.2	-1.7	1.7	1.7	-0.6
Bone: cortical area	0.4	0.6	1.7	-0.3	-1.1	0.3	-0.3	-0.3	1.3
Bone: cortical porosity	0.6	0.7	1.2	1.1	0.1	0.9	-1.0	-1.0	0.4
Bone: cortical porosity	1.0	1.0	1.5	1.2	0.1	1.1	-1.2	-1.2	0.7
Bone: cortical thickness	1.1	1.8	3.7	-1.8	-1.9	-0.9	1.0	1.0	1.0
Bone: cortical thickness	1.2	1.4	2.7	-1.7	-1.4	-1.1	1.1	1.1	0.3
Bone: cortical tissue density	1.7	2.2	3.7	-1.9	-1.1	-1.7	1.6	1.6	-0.7
Condit. Reinf. active minus inactive responses	1.2	1.4	3.5	0.4	-1.2	1.0	-1.0	-1.0	1.9
Condit. Reinf. active-inactive response ratio	0.4	0.5	1.5	0.3	-0.6	0.6	-0.5	-0.5	1.2
Condit. Reinf. active responses	2.0	2.4	5.9	0.6	-1.5	1.4	-1.4	-1.4	2.4
Condit. Reinf. inactive responses	0.9	1.1	2.1	0.7	-0.8	1.1	-1.1	-1.1	1.4
Incentive salience index mean	1.5	1.8	4.5	0.5	-1.4	1.2	-1.2	-1.2	2.1
Condit. Reinf. lever presses	1.2	1.6	2.2	1.0	-0.5	1.4	-1.4	-1.4	1.5
Condit. Reinf. active minus inactive responses	6.3	7.8	11.8	2.0	-1.8	3.1	-3.0	-3.0	3.4
Condit. Reinf. active-inactive response ratio	3.8	4.0	10.1	0.9	-1.8	1.9	-1.8	-1.8	3.2
Condit. Reinf. active responses	5.0	7.0	9.3	2.1	-1.5	3.1	-2.9	-2.9	3.0
Condit. Reinf. inactive responses	1.4	1.7	2.7	1.3	-0.3	1.6	-1.6	-1.6	0.8
Condit. Reinf. lever presses	2.8	3.7	9.7	0.5	-2.2	1.7	-1.5	-1.5	3.1
Condit. Reinf. lever reinforcers received	4.5	6.3	9.5	1.8	-1.7	2.8	-2.7	-2.7	3.1
Conditioned reinforcement - actives	0.4	0.4	1.1	1.0	1.0	0.4	-0.3	-0.3	0.1
Conditioned reinforcement - inactives	1.0	1.1	1.4	1.2	-0.2	1.2	-1.1	-1.1	1.1
Conditioned locomotion	1.5	1.8	5.2	0.4	2.3	-0.9	1.0	1.0	-1.7
Patch foraging indifference point 0 sec	0.9	1.5	2.5	-1.6	-0.8	-1.3	1.3	1.3	-0.7
Patch foraging indifference point AUC	0.9	1.0	1.3	0.4	-1.1	1.1	-1.1	-1.1	1.1
Delay disc. indifference point, 0s delay	0.8	0.9	1.6	1.3	0.9	0.9	-1.0	-1.0	0.4
Delay disc. indifference point, 16s delay	0.9	0.9	1.5	1.2	0.8	1.1	-1.0	-1.0	-0.3
Delay disc. indifference point, 2s delay	0.4	0.4	0.8	0.9	0.6	0.6	-0.7	-0.7	0.4
Delay disc. indifference point, 24s delay	3.1	3.0	4.7	2.2	1.2	2.0	-2.0	-2.0	-0.2
Delay disc. indifference point, 4s delay	0.9	1.0	1.6	1.3	0.4	1.1	-1.1	-1.1	0.2
Delay disc. indifference point, 8s delay	1.6	1.7	3.0	1.7	1.7	1.1	-1.1	-1.1	-0.6
Indifference point function ln k	0.2	0.3	0.5	-0.3	0.5	-0.7	0.6	0.6	-0.5
Indifference point function log k	0.2	0.3	0.5	-0.3	0.5	-0.7	0.6	0.6	-0.5
Patch foraging total patch changes 0 sec	0.4	0.7	1.4	-1.2	-0.9	-0.8	0.8	0.8	-0.3
Patch foraging total patch changes 12 sec	0.3	0.4	1.2	-0.0	-1.1	0.6	-0.6	-0.6	0.5
Patch foraging total patch changes 18 sec	0.7	0.9	2.0	0.2	-1.4	0.9	-0.8	-0.9	1.1
Patch foraging total patch changes 24 sec	0.8	1.0	1.6	0.7	-0.6	1.3	-1.2	-1.2	0.7
Patch foraging total patch changes 6 sec	0.4	0.6	1.1	-1.1	-0.9	-0.6	0.7	0.7	-0.4
Patch foraging time to switch 0 sec	0.2	0.3	1.0	0.4	1.0	-0.3	0.3	0.3	-0.6
Patch foraging water rate 0 sec	0.1	0.1	0.3	-0.3	-0.6	-0.0	-0.1	-0.1	0.3
Patch foraging water rate 12 sec	0.3	0.5	0.9	0.7	0.9	0.6	-0.7	-0.6	-0.5
Patch foraging water rate 18 sec	0.2	0.3	0.8	-0.3	0.7	-0.5	0.4	0.4	-0.9
Patch foraging water rate 24 sec	0.2	0.3	1.0	0.2	1.0	-0.2	0.2	0.2	-0.8
Patch foraging water rate 6 sec	0.1	0.2	0.5	-0.2	0.5	-0.5	0.4	0.4	-0.7
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	2.1	-0.7	0.7	-1.2	1.2	1.2	-1.4
Distance traveled before self-admin	1.2	1.3	2.4	-1.5	-1.2	-1.2	1.1	1.1	-0.0
Distance traveled after self-admin	2.4	2.6	4.0	-1.3	0.8	-1.8	1.8	1.8	-2.0
Extensor digitorum longus weight	0.7	2.9	4.5	1.6	-0.2	2.1	-2.0	-2.0	1.4
Bone: elastic displacement	0.2	0.2	0.4	0.6	0.2	0.4	-0.5	-0.5	0.1
Bone: elastic work	0.1	0.1	0.5	0.1	0.7	-0.1	0.1	0.1	-0.5
Bone: endosteal estimation	0.8	1.7	4.0	1.7	2.0	1.0	-1.0	-1.0	-0.7
Bone: endosteal perimeter	0.3	0.7	1.0	1.0	0.9	0.9	-0.9	-0.9	-0.0
Epididymis fat weight	2.8	6.6	10.5	3.2	2.6	2.8	-2.7	-2.7	0.6
Delta time in closed arm before/after self-admin	1.7	1.7	2.4	-1.4	-1.1	-1.4	1.5	1.5	-0.1
Delta time in open arm before/after self-admin	1.7	1.6	2.5	1.6	1.0	1.3	-1.5	-1.5	0.4
Diff in mean of infusions in LGA sessions	0.3	0.3	1.1	-0.4	-0.8	-0.1	0.0	0.0	1.0
Delay discount exponential model param	1.9	2.0	3.6	-1.9	-1.4	-1.5	1.5	1.5	0.3
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.5	0.0	0.4	-0.5	-0.5	0.3
Active lever presses in extinction session 6	0.4	0.4	1.2	-0.2	-1.1	0.3	-0.3	-0.3	0.9
Bone: final force	0.3	0.4	1.0	-0.3	0.7	-0.5	0.6	0.6	-1.0
Bone: final moment	0.2	0.4	0.8	-0.0	0.9	-0.3	0.4	0.4	-0.9
Food consumed during 24 hour testing period	0.2	0.2	0.4	0.6	0.6	0.3	-0.3	-0.3	-0.6
Glucose	0.2	0.3	1.6	0.4	1.3	0.0	-0.0	-0.0	-0.5
Heart weight	2.0	2.9	8.3	-2.1	-2.9	-0.9	0.9	0.9	1.4
Delay discount hyperbolic model param	1.7	1.8	3.2	-1.8	-1.3	-1.4	1.4	1.4	0.3
Intermittent access intake day 1-15 change	1.9	1.9	4.3	2.1	1.3	1.4	-1.3	-1.3	0.3
Intermittent access intake escalation	1.0	1.0	2.5	1.6	1.3	0.9	-0.8	-0.8	-0.0
Intermittent access intake escalation 2	1.9	1.9	4.5	1.9	2.1	1.0	-0.9	-0.9	-0.5
Intermitt. access day 1 inactive lever presses	1.4	1.5	2.1	1.2	0.2	1.4	-1.5	-1.5	1.0
Intermitt. access day 15 inactive lever presses	0.2	0.2	0.7	0.4	0.0	0.4	-0.4	-0.4	0.8
Intermitt. access escalation Index	0.2	0.2	0.4	0.1	0.6	-0.2	0.4	0.4	-0.4
Intermittent access day 1 total infusions	1.6	1.9	2.7	1.5	0.2	1.6	-1.6	-1.6	1.0
Intermittent access day 15 total infusions	3.0	3.4	6.4	2.5	1.2	2.0	-2.0	-2.0	0.9
Intermittent access terminal intake (last 3 days)	3.4	3.7	7.3	2.7	1.9	1.9	-1.9	-1.9	0.5
Intermittent access total infusions	3.1	3.4	6.0	2.4	1.3	2.0	-2.0	-2.0	0.6
Intermittent access day 1 locomotion	0.1	0.1	0.3	0.1	0.5	-0.3	0.2	0.2	-0.3
Intermittent access day 15 total locomotion	0.7	0.8	1.5	1.2	0.6	1.0	-1.0	-1.0	0.1
Intermittent access total locomotion	0.5	0.5	1.6	0.4	1.3	-0.3	0.3	0.3	-1.0
Intermittent access standard deviation	4.3	4.5	9.1	3.0	1.9	2.2	-2.2	-2.2	0.3
Left kidney weight	2.1	6.0	11.0	-1.2	2.4	-2.4	2.5	2.5	-3.3
Right kidney weight	0.9	2.6	6.0	-0.3	2.2	-1.2	1.2	1.2	-2.4
Cocaine induced anxiety	5.1	5.9	9.1	-3.0	-0.8	-2.9	2.9	2.9	-1.1
Post-drug Anxiety	2.5	2.8	4.0	-2.0	-0.3	-2.0	2.0	2.0	-1.0
Baseline Anxiety	3.9	4.2	6.2	2.2	0.4	2.5	-2.5	-2.5	1.3
Tail length	0.9	2.7	4.0	2.0	0.4	2.0	-2.0	-2.0	0.7
Length with tail	0.5	1.7	2.9	1.6	1.7	1.2	-1.1	-1.1	-1.0
Length without tail	0.2	0.5	1.5	-0.3	0.9	-0.5	0.5	0.5	-1.2
Times rat made contact with spout	0.1	0.1	0.2	0.1	-0.1	0.2	-0.4	-0.4	-0.4
Lifetime Intake	2.9	3.2	5.8	2.4	1.1	2.0	-2.0	-2.0	0.7
Liver weight, left	0.5	0.8	1.3	0.7	-0.6	1.1	-1.1	-1.1	0.7
Liver weight, right	2.2	3.6	7.3	2.3	2.7	1.5	-1.4	-1.4	-1.6
Locomotor activity	1.0	1.6	2.8	-1.7	-0.8	-1.5	1.3	1.3	-0.9
Locomotor testing distance	2.3	3.8	5.6	-2.4	-0.7	-2.3	2.2	2.2	-1.3
Locomotor testing rearing	1.2	1.9	3.2	-1.3	0.2	-1.5	1.4	1.4	-1.8
Locomotion in novel chamber	1.0	1.2	2.3	-1.5	-1.2	-1.1	1.1	1.1	0.1
Locomotion in novel chamber post-restriction	0.1	0.1	0.2	-0.1	0.4	-0.4	0.4	0.4	-0.2
Fecal boli incidents, locomotor time 1	0.9	1.0	1.4	1.2	0.9	1.1	-1.0	-1.0	-0.3
Change in fecal boli incidents, locomotor task	0.6	0.5	1.7	0.3	-0.7	0.6	-0.6	-0.6	1.3
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.3	-0.4	0.1	-0.6	0.5	0.5	-0.1
Bouts of movement, locomotor time 1	4.3	4.7	7.6	2.8	1.3	2.5	-2.5	-2.5	0.7
Total resting periods, locomotor time 1	4.5	4.9	7.8	2.8	1.3	2.6	-2.5	-2.5	0.8
Rest time, locomotor task time 1	0.1	0.2	0.5	-0.4	-0.7	0.0	-0.0	-0.0	0.6
Distance moved, locomotor task time 1	0.2	0.3	0.8	0.7	0.9	0.3	-0.3	-0.3	-0.2
Vertical activity count, locomotor time 1	0.8	0.8	1.4	-1.2	-0.8	-1.0	0.9	0.9	0.2
Time >=10cm from walls, locomotor time 2	0.3	0.3	0.8	-0.7	-0.9	-0.2	0.2	0.2	0.6
Bouts of movement, locomotor time 2	3.4	3.6	5.8	2.4	1.1	2.2	-2.2	-2.2	-0.1
Total resting periods, locomotor time 2	3.0	3.2	5.2	2.3	1.2	2.1	-2.1	-2.1	-0.4
Rest time, locomotor task time 2	0.6	0.6	1.7	-0.1	0.9	-0.6	0.7	0.7	-1.3
Distance moved, locomotor task time 2	0.4	0.4	0.9	0.2	-0.8	0.6	-0.6	-0.6	1.0
Vertical activity count, locomotor time 2	0.7	0.7	2.5	-1.1	-1.6	-0.3	0.2	0.2	0.7
Light reinforcement 1	0.2	0.4	1.6	-0.8	-1.3	-0.3	0.2	0.2	0.5
Light reinforcement 2	0.3	0.4	0.8	-0.1	-0.9	0.5	-0.6	-0.6	0.6
Bone: marrow area	0.8	1.7	4.0	1.7	2.0	1.0	-1.0	-1.0	-0.7
Bone: maximum diameter	0.5	0.8	2.0	0.4	-0.7	0.9	-0.9	-0.9	1.4
Bone: maximum force	0.0	0.0	0.1	-0.1	0.3	-0.1	0.2	0.2	-0.2
Bone: maximum moment	0.0	0.1	0.3	0.3	0.5	0.2	-0.1	-0.1	-0.1
Mean time between licks in bursts	0.9	1.2	2.4	1.6	0.7	1.2	-1.1	-1.1	0.6
Mean num. licks in bursts	1.0	1.1	2.2	-0.9	0.1	-1.2	1.1	1.1	-1.5
Cd content in liver	2.3	2.5	5.0	-2.0	-2.2	-1.4	1.4	1.4	0.5
Co content in liver	2.7	3.2	4.4	-2.0	-0.5	-2.1	2.1	2.1	-1.3
Cu content in liver	0.5	0.6	2.5	0.4	1.0	0.0	0.1	0.1	-1.6
Fe content in liver	1.1	1.3	2.3	-1.5	-1.3	-1.0	1.0	1.0	-0.7
K content in liver	1.6	1.6	2.6	1.6	1.3	1.2	-1.2	-1.2	-0.8
Mg content in liver	2.8	2.9	4.6	2.1	1.1	2.0	-1.9	-1.9	0.0
Mn content in liver	0.7	0.8	1.9	0.0	-1.2	0.7	-0.7	-0.7	1.4
Na content in liver	2.2	2.3	3.4	1.4	-0.6	1.8	-1.8	-1.8	1.1
Rb content in liver	0.6	0.7	1.3	1.1	0.2	1.0	-1.0	-1.0	0.5
Se content in liver	0.2	0.2	0.9	0.1	0.7	-0.2	0.2	0.2	-1.0
Sr content in liver	0.7	0.7	2.1	0.8	1.4	0.0	-0.0	-0.0	-1.2
Zn content in liver	0.1	0.1	0.5	-0.2	-0.7	0.1	-0.1	-0.1	-0.1
Bone: minimum diameter	0.5	1.0	1.4	1.1	0.4	1.2	-1.2	-1.2	0.6
Time in familiar zone, hab. session 1	1.7	1.6	2.1	-0.7	1.0	-1.5	1.5	1.5	-1.2
Time in novel zone, hab. session 1	2.4	2.3	3.5	1.2	-0.6	1.9	-1.8	-1.8	1.4
Total zone transitions, hab. session 1	0.4	0.6	1.8	-0.9	-1.3	-0.3	0.3	0.3	0.8
Total locomotion distance, hab. session 1	0.3	0.4	1.2	-0.0	-0.9	0.4	-0.4	-0.4	1.1
Locomotion velocity, hab. session 1	0.4	0.6	1.6	-0.3	-1.3	0.3	-0.3	-0.3	1.2
Time in familiar zone, hab. session 2	3.0	3.1	4.7	2.2	0.8	2.1	-2.1	-2.1	0.8
Time in novel zone, hab. session 2	2.1	2.1	3.0	-1.7	-0.5	-1.7	1.7	1.7	-0.9
Total zone transitions, hab. session 2	0.1	0.1	0.3	0.0	-0.4	0.2	-0.3	-0.3	0.6
Total locomotion distance, hab. session 2	0.3	0.3	0.9	0.1	-0.6	0.5	-0.5	-0.5	0.9
Locomotion velocity, hab. session 2	0.3	0.3	1.0	-0.1	-0.8	0.4	-0.4	-0.4	1.0
Novel to familiar place preference ratio	0.3	0.3	0.6	0.7	0.6	0.5	-0.5	-0.5	0.5
Novelty place preference	0.6	0.6	1.3	1.1	1.0	0.7	-0.7	-0.7	0.2
Time in novel zone, NPP test	1.3	1.3	2.5	1.6	1.1	1.2	-1.2	-1.2	0.4
Total zone transitions, NPP test	0.5	0.7	1.7	0.0	-1.0	0.7	-0.7	-0.7	1.3
Total locomotion distance, NPP test	0.7	1.0	2.1	0.3	-1.0	1.0	-1.0	-1.0	1.4
Locomotion velocity, NPP test	0.3	0.4	1.2	-0.3	-1.0	0.3	-0.3	-0.3	1.1
Intraocular pressure	1.2	1.7	2.5	1.4	0.1	1.6	-1.6	-1.6	0.9
Delta distance traveled before/after self-admin	1.8	1.9	4.4	0.1	2.1	-0.9	0.9	0.9	-2.1
Delta ambulatory time before/after self-admin	1.0	1.1	4.2	0.7	2.0	-0.2	0.3	0.3	-1.4
Parametrial fat weight	1.6	3.0	5.0	2.2	1.6	1.9	-1.9	-1.9	-0.2
Pavlov. Cond. lever latency	0.1	0.2	0.3	-0.5	-0.1	-0.5	0.5	0.5	-0.2
Pavlov. Cond. magazine entry latency	0.4	0.6	0.8	0.8	0.4	0.9	-0.9	-0.9	0.5
Pavlov. Cond. change in total contacts	0.1	0.1	0.1	0.2	0.3	0.2	-0.2	-0.2	0.2
Pavlov. Cond. index score	0.3	0.4	0.6	0.7	0.3	0.8	-0.8	-0.8	0.3
Pavlov. Cond. latency score	0.3	0.3	0.5	0.7	0.5	0.7	-0.7	-0.7	0.2
Pavlov. Cond. lever contacts	0.6	0.7	1.1	1.1	0.4	1.0	-1.0	-1.0	0.4
Pavlov. Cond. magazine entry number	0.3	0.4	0.6	-0.8	-0.7	-0.7	0.7	0.7	0.0
Pavlov. Cond. intertrial magazine entries	0.3	0.3	1.0	-0.8	-1.0	-0.4	0.3	0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	0.8	0.2	1.0	-0.9	-0.9	0.5
Pavlov. Cond. response bias	0.4	0.5	0.7	0.8	0.6	0.8	-0.8	-0.8	0.2
Pavlov. Cond. lever latency	2.5	3.4	7.0	-0.9	1.6	-1.9	1.8	1.8	-2.7
Pavlov. Cond. magazine entry latency	1.1	1.3	2.1	1.4	0.4	1.4	-1.3	-1.3	0.5
Pavlov. Cond. change in total contacts	3.0	4.1	5.8	1.8	-0.8	2.4	-2.3	-2.3	2.2
Pavlov. Cond. index score	1.9	2.4	3.2	1.3	-0.7	1.8	-1.7	-1.7	1.8
Pavlov. Cond. latency score	2.0	2.5	3.6	1.5	-0.4	1.9	-1.8	-1.8	1.6
Pavlov. Cond. lever contacts	1.9	2.6	6.7	0.2	-2.0	1.4	-1.3	-1.3	2.6
Pavlov. Cond. magazine entry number	1.5	1.8	2.8	-1.7	-0.6	-1.6	1.6	1.6	-0.5
Pavlov. Cond. intertrial magazine entries	0.4	0.5	1.2	-1.0	-1.1	-0.6	0.5	0.5	0.4
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.5	3.4	1.4	-0.6	1.8	-1.7	-1.7	1.8
Pavlov. Cond. response bias	1.7	2.3	5.2	0.6	-1.6	1.5	-1.4	-1.4	2.3
Time in closed arm before self-admin	0.4	0.4	0.6	0.6	0.7	0.6	-0.8	-0.8	-0.4
Time in closed arm after self-admin	0.1	0.1	0.2	0.0	-0.4	0.1	-0.1	-0.1	0.5
Time in open arm before self-admin	0.4	0.5	1.5	-0.6	-1.2	-0.4	0.5	0.5	0.5
Time in open arm after self-admin	0.7	0.8	1.2	1.1	0.3	1.0	-1.0	-1.0	0.6
Bone: periosteal estimation	0.2	0.5	0.7	0.9	0.8	0.7	-0.7	-0.7	0.0
Bone: periosteal perimeter	0.1	0.2	0.4	0.5	0.3	0.6	-0.6	-0.6	0.2
Bone: post-yield work	1.4	1.9	2.6	1.4	-0.2	1.6	-1.6	-1.6	1.2
Progressive ratio test 1 active lever presses	0.9	1.0	2.1	1.5	1.0	0.9	-1.0	-1.0	-0.1
Progressive ratio test 1 breakpoint	1.1	1.2	2.3	1.5	0.8	1.1	-1.2	-1.2	0.1
Progressive ratio test 1 inactive lever presses	2.3	2.5	3.3	1.8	0.2	1.8	-1.8	-1.8	1.4
Progressive ratio test 2 active lever presses	2.5	2.7	5.8	2.4	2.1	1.4	-1.4	-1.4	-0.1
Progressive ratio test 2 breakpoint	2.8	3.2	6.7	2.6	2.1	1.6	-1.6	-1.6	-0.0
Progressive ratio test 2 inactive lever presses	2.7	3.1	6.1	2.5	2.0	1.7	-1.6	-1.6	0.3
Incentive Sensitization - Responses	2.4	2.4	5.0	2.2	1.5	1.6	-1.5	-1.5	0.3
Incentive Sensitization - Breakpoint	2.2	2.3	4.7	2.2	1.5	1.5	-1.5	-1.5	0.4
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.8	-0.1	-0.9	0.4	-0.3	-0.3	0.7
Progressive ratio	0.2	0.2	0.7	-0.6	-0.8	-0.3	0.3	0.3	0.1
Food seeking constrained by brief footshock	0.5	0.6	1.8	0.3	-0.8	0.7	-0.6	-0.6	1.4
Seeking ratio, punishment vs. effort	0.9	1.1	1.4	1.2	0.4	1.1	-1.1	-1.1	1.1
Retroperitoneal fat weight	2.7	8.9	27.3	3.6	5.2	1.7	-1.8	-1.8	-1.9
Reaction time number correct	1.0	1.4	3.8	0.8	2.0	-0.1	0.1	0.1	-2.0
Reaction time mean minus median	0.1	0.1	0.3	0.2	0.6	-0.1	0.2	0.2	-0.5
Reaction time mean minus median AUC	0.3	0.4	1.5	0.3	1.2	-0.2	0.3	0.3	-0.8
Reaction time num false alarms	1.2	1.6	2.4	0.7	-1.0	1.4	-1.4	-1.4	1.5
Reaction time num false alarms AUC	0.8	1.1	2.4	-0.0	-1.5	0.8	-0.8	-0.8	1.6
Reaction time trials correct on left	1.0	1.4	3.8	0.8	2.0	-0.1	0.1	0.1	-2.0
Reaction time trials on left	1.0	1.4	3.9	0.8	2.0	-0.1	0.1	0.1	-2.0
Reaction time mean	0.4	0.6	1.3	-0.3	0.7	-0.8	0.7	0.7	-1.1
Reaction time mean AUC	0.3	0.3	0.6	-0.2	0.6	-0.6	0.6	0.6	-0.8
Median of all reaction times	0.7	0.9	1.8	-0.5	0.8	-1.0	1.0	1.0	-1.3
Reaction time omissions	0.3	0.5	1.5	0.9	1.2	0.2	-0.2	-0.2	-0.6
Reaction time false alarm rate	1.9	2.6	7.1	0.0	-2.2	1.1	-1.1	-1.1	2.7
Reaction time premature initiation rate	1.3	1.7	3.8	-1.9	-1.0	-1.5	1.3	1.3	-0.0
Reaction time premature initiations	1.4	1.9	2.7	-1.6	0.1	-1.6	1.5	1.5	-1.3
Std. dev. reaction times	0.2	0.3	0.9	0.6	1.0	0.2	-0.1	-0.1	-0.4
Reaction time trials completed	1.0	1.4	3.9	0.8	2.0	-0.1	0.1	0.1	-2.0
Reaction time trials AUC	1.0	1.4	3.9	0.9	2.0	-0.0	0.0	-0.0	-2.0
Run reversals in cocaine runway, females	1.7	1.7	4.5	-0.6	1.4	-1.2	1.0	1.0	-2.1
Run reversals in cocaine runway, males	0.3	0.3	0.5	-0.7	-0.4	-0.6	0.6	0.6	0.3
Latency to leave start box in cocaine runway	0.3	0.4	0.8	-0.8	-0.9	-0.5	0.5	0.5	-0.3
Latency to leave start box in cocaine runway, F	2.7	3.0	5.0	-2.2	-1.5	-1.8	1.8	1.8	-1.0
Latency to leave start box in cocaine runway, M	1.6	1.6	2.3	1.4	0.2	1.5	-1.5	-1.5	0.6
Std. dev. time between licks in bursts	2.0	2.4	3.2	1.8	0.1	1.8	-1.7	-1.7	1.5
Total sessions with >9 infusions	0.8	0.9	2.1	1.4	1.5	0.5	-0.7	-0.7	-0.6
Short access day 1 total inactive lever presses	1.0	1.2	2.4	1.5	0.7	1.1	-1.2	-1.2	0.4
Short access day 10 total inactive lever presses	0.1	0.1	0.2	0.4	0.4	0.4	-0.3	-0.3	0.3
Short access day 1 total infusions	1.0	1.1	2.4	1.5	1.5	0.7	-0.8	-0.8	-0.5
Short access day 10 total infusions	2.0	2.3	3.3	1.8	0.6	1.7	-1.8	-1.8	0.8
Short access total infusions	1.9	2.1	4.0	2.0	1.0	1.5	-1.6	-1.6	0.5
Short access day 1 locomotion	2.1	2.2	4.4	2.0	2.1	1.2	-1.3	-1.3	-0.6
Short access day 10 total locomotion	1.3	1.4	4.1	-0.0	2.0	-0.8	0.9	0.9	-1.4
Short access total locomotion	0.6	0.6	2.3	0.4	1.5	-0.4	0.3	0.3	-0.9
One hour access (0.3 mA shock)	5.6	6.5	12.9	3.6	2.5	2.6	-2.6	-2.6	0.1
Compulsive drug intake	0.2	0.2	0.7	-0.5	-0.8	-0.2	0.3	0.3	0.2
One hour access (shock baseline)	2.9	3.3	6.5	2.6	2.0	1.8	-1.8	-1.8	0.1
Social response proportion	3.5	3.8	11.3	0.7	3.4	-0.9	0.9	0.9	-3.0
Social responses	1.2	1.5	5.0	0.5	2.2	-0.5	0.5	0.5	-1.7
Social time	2.1	2.8	6.3	-0.1	2.4	-1.3	1.3	1.3	-2.5
Soleus weight	0.7	2.1	6.4	0.7	2.4	-0.1	0.1	0.1	-2.5
Bone: stiffness	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.4	0.4	-0.1
Tibialis anterior weight	0.5	1.8	2.6	1.1	-0.5	1.6	-1.6	-1.6	1.4
Time to tail flick, vehicle, before self-admin	0.2	0.3	0.5	0.6	0.7	0.3	-0.3	-0.3	-0.6
Time to tail flick, vehicle, after self-admin	0.1	0.1	0.2	-0.5	0.0	-0.4	0.3	0.3	-0.5
Time to tail flick, test, before self-admin	0.6	0.6	1.3	-0.7	0.3	-0.7	0.7	0.7	-1.2
Time to tail flick, test, after self-admin	0.2	0.2	0.3	0.4	-0.1	0.6	-0.5	-0.5	0.1
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.5	-0.3	-0.4	0.3	0.3	0.1
Delta time to tail flick, test, before/after SA	0.3	0.3	0.3	0.5	-0.1	0.6	-0.5	-0.5	0.6
Tibia length	2.3	6.5	9.4	-2.8	0.2	-3.1	3.0	3.0	-1.7
Ambulatory time before self-admin	1.2	1.3	2.2	-1.5	-1.1	-1.3	1.2	1.2	-0.2
Ambulatory time after self-admin	3.3	3.6	6.9	-1.2	1.3	-2.0	1.9	1.9	-2.6
Bone: tissue strength	0.7	0.7	1.1	1.1	0.4	0.9	-0.9	-0.9	0.6
Total heroin consumption	1.4	1.7	2.3	1.4	0.2	1.5	-1.5	-1.5	1.0
Bone: trabecular number	1.7	2.6	4.8	2.2	1.7	1.6	-1.6	-1.6	-0.2
Bone: trabecular spacing	0.5	0.6	1.8	-0.5	-1.3	0.1	-0.1	-0.1	1.2
Bone: trabecular thickness	2.4	2.8	4.6	2.1	1.8	1.8	-1.7	-1.7	-0.4
Bone: trabecular tissue density	0.1	0.2	0.3	-0.6	-0.5	-0.3	0.4	0.4	-0.3
Water consumed over 24 hours	0.5	0.6	2.1	0.2	1.0	-0.4	0.4	0.4	-1.5
Number of responses in last shaping day	0.2	0.2	0.3	-0.2	0.3	-0.5	0.5	0.5	-0.4