LOC102557216

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	PL	alternative polyA	XR_010060121.1	0.05	0.04	2.1e-03	0.02	0.03	0	0.02	4.1e-03	7.9e-04	1.4e-01	1.9e-03
2	LHb	gene expression	LOC102557216	0.19	0.12	7.7e-03	0.03	0.02	-0.01	0	7.5e-02	1.1e-01	6.0e-01	2.5e-01
3	Brain	gene expression	LOC102557216	0.1	0.05	1.8e-14	0.15	0.15	0.15	0.15	2.9e-14	1.1e-13	7.3e-14	1.0e-13
4	pVTA	gene expression	LOC102557216	0.21	0.09	0.0e+00	0.24	0.25	0.23	0.25	4.6e-19	8.9e-20	7.9e-19	7.0e-20
5	NAcc	gene expression	LOC102557216	0.05	0.03	4.0e-11	0.06	0.07	0.05	0.07	3.7e-10	1.3e-10	1.7e-08	2.0e-10
6	BLA	gene expression	LOC102557216	0.09	0.06	1.8e-03	0.01	0.03	0.01	0.02	1.5e-01	7.2e-03	1.5e-01	4.3e-02
7	Brain	alternative polyA	XR_010060121.1	0.09	0.09	2.1e-04	0.04	0.03	0.05	0.03	9.8e-05	1.4e-03	3.9e-05	7.1e-04

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6	7
Bone: apparent density	1.8	3.2	10.8	3.3	1.8	1.7	-1.5	-1.5	-1.0	0.5
Area under the delay curve	0.3	0.5	0.8	-0.9	-0.7	-0.8	0.8	0.7	0.6	-0.0
BMI with tail	2.3	8.1	11.1	-3.3	-3.3	-2.8	2.7	2.6	2.3	-2.8
BMI without tail	0.2	0.9	1.2	-1.1	-0.6	-1.1	1.1	0.9	0.7	-0.9
Body weight	0.6	2.6	8.5	-2.9	-1.8	-1.3	1.4	1.0	0.5	-1.4
Weight adjusted by age	1.5	4.3	6.5	-2.0	-2.6	-2.0	2.0	1.8	1.8	-2.2
Bone surface	0.6	1.2	3.8	2.0	1.0	1.0	-0.9	-1.0	-0.8	-0.5
Bone volume	1.6	3.2	6.5	2.6	1.6	1.9	-1.9	-1.9	-1.6	-0.0
Breakpoint value in progressive ratio session	0.5	0.9	1.6	1.3	1.2	0.6	-0.8	-0.6	-0.4	1.2
Number of licking bursts	0.2	0.7	1.5	0.4	0.8	0.8	-0.8	-0.7	-0.7	1.2
Context. condit. distance diff. score	2.7	3.2	5.9	-1.2	-0.9	-2.3	1.9	2.3	2.4	-0.2
Locomotion velocity, session 1	0.8	0.9	3.1	-0.4	1.1	0.5	-0.2	-0.7	-1.0	1.8
Locomotion distance, session 1	0.2	0.3	1.4	0.1	0.6	0.1	0.0	0.0	0.0	1.2
Locomotion velocity, session 2	0.2	0.2	0.7	0.5	0.9	-0.1	0.2	0.1	0.2	0.6
Locomotion distance, session 2	0.1	0.2	0.3	-0.2	0.0	-0.3	0.6	0.5	0.5	0.4
Locomotion velocity, session 3	2.4	2.8	4.1	-2.0	-1.8	-1.7	1.6	1.6	1.4	-1.5
Locomotion distance, session 3	0.4	0.5	2.1	-1.4	-0.5	-0.6	0.3	0.6	0.3	-0.2
Stereotopy head waving bouts, day 3	0.9	1.1	1.6	-1.0	-0.9	-1.1	1.3	1.1	1.0	-0.9
Stereotopy head waving duration, day 3	1.2	1.4	2.6	-1.0	-1.1	-1.3	1.6	1.3	1.2	-0.7
Locomotion velocity, session 7	0.9	1.0	2.7	0.3	-0.5	-1.1	1.0	1.3	1.6	0.1
Locomotion distance, session 7	0.8	1.0	3.8	1.9	1.1	0.5	-0.5	-0.2	0.3	1.2
Stereotopy head waving bouts, day 7	1.8	2.1	6.1	-2.5	-1.6	-1.2	1.3	1.0	0.5	-1.2
Stereotopy head waving duration, day 7	0.5	0.6	3.0	-1.7	-0.7	-0.1	0.2	-0.1	-0.7	-0.6
Locomotion velocity, session 8	0.9	1.1	2.3	0.2	-0.3	-1.1	1.2	1.3	1.5	0.8
Locomotion distance, session 8	1.1	1.6	3.3	-0.6	-0.3	-1.5	1.4	1.7	1.8	0.7
Degree of sensitization distance	1.0	1.1	5.5	2.3	0.9	0.5	-0.1	-0.3	0.3	1.0
Degree of sensitization stereotypy	1.5	1.6	5.0	-2.2	-1.5	-1.1	1.1	0.9	0.4	-1.0
Conditioned locomotion	0.2	0.2	0.3	0.5	0.4	0.4	-0.5	-0.5	-0.4	0.1
Cocaine response after cond. corrected	0.7	1.1	2.2	-0.3	-0.6	-1.3	1.3	1.3	1.5	0.4
Cocaine response after cond. not corrected	0.5	0.8	1.1	-0.7	-0.8	-1.0	1.1	1.0	1.0	0.0
Cocaine response before conditioning	1.1	1.4	3.3	-0.2	0.4	1.4	-1.3	-1.5	-1.8	-0.4
Saline control response	2.8	3.8	8.3	2.9	2.5	1.5	-0.8	-1.2	-0.7	2.8
Bone: connectivity density	2.0	3.2	13.8	3.7	1.7	1.4	-1.3	-1.2	-0.5	0.4
Bone: cortical apparent density	0.2	0.3	0.9	0.9	0.1	-0.2	0.0	0.5	0.8	-0.3
Bone: cortical area	0.2	0.3	0.4	0.4	0.3	0.5	-0.7	-0.6	-0.6	-0.5
Bone: cortical porosity	0.5	0.5	2.8	-1.7	-0.8	-0.1	0.2	-0.1	-0.4	-0.3
Bone: cortical porosity	0.3	0.4	1.8	-1.3	-0.5	0.3	-0.1	-0.3	-0.7	-0.0
Bone: cortical thickness	0.1	0.2	0.6	0.2	0.0	0.4	-0.5	-0.3	-0.3	-0.8
Bone: cortical thickness	0.2	0.3	0.6	0.7	-0.1	-0.3	0.7	0.5	0.8	-0.1
Bone: cortical tissue density	0.2	0.3	0.9	0.9	0.1	-0.3	0.1	0.7	0.9	-0.3
Condit. Reinf. active minus inactive responses	0.6	0.7	1.1	-0.9	-0.6	-0.8	0.6	1.1	0.9	-1.0
Condit. Reinf. active-inactive response ratio	1.1	1.1	1.7	-1.3	-0.6	-1.1	1.1	1.3	1.1	-0.7
Condit. Reinf. active responses	0.1	0.1	0.3	-0.2	-0.1	0.2	-0.3	-0.0	-0.2	-0.6
Condit. Reinf. inactive responses	2.4	3.1	4.3	1.7	1.3	2.0	-2.1	-2.0	-2.0	0.9
Incentive salience index mean	0.2	0.2	0.7	0.1	0.5	0.6	-0.8	-0.3	-0.5	-0.1
Condit. Reinf. lever presses	1.2	1.8	3.6	0.9	1.3	1.4	-1.9	-1.4	-1.5	0.7
Condit. Reinf. active minus inactive responses	0.1	0.2	0.5	-0.7	-0.5	-0.3	0.2	0.3	0.2	-0.7
Condit. Reinf. active-inactive response ratio	0.3	0.5	1.5	-0.9	-0.9	-0.2	0.3	0.0	-0.1	-1.2
Condit. Reinf. active responses	0.1	0.2	0.5	-0.7	-0.2	-0.3	0.4	0.4	0.2	-0.3
Condit. Reinf. inactive responses	0.3	0.4	0.7	-0.5	-0.1	-0.8	0.8	0.9	0.8	0.3
Condit. Reinf. lever presses	0.6	0.8	1.0	-0.9	-0.8	-1.0	0.9	1.0	0.9	-0.9
Condit. Reinf. lever reinforcers received	0.4	0.6	1.4	-1.2	-0.7	-0.7	0.7	0.7	0.5	-0.7
Conditioned reinforcement - actives	0.0	0.2	0.9	-0.2	0.2	0.1	0.1	-0.2	-0.3	1.0
Conditioned reinforcement - inactives	0.2	0.4	1.6	-1.3	-0.4	-0.6	0.7	0.5	0.3	0.2
Conditioned locomotion	0.1	0.1	0.6	0.5	0.3	0.1	-0.1	-0.1	-0.0	0.8
Patch foraging indifference point 0 sec	0.5	1.4	2.7	-1.1	-0.6	-1.2	1.6	1.4	1.3	-0.1
Patch foraging indifference point AUC	0.8	1.8	2.5	1.2	1.5	1.5	-1.6	-1.4	-1.3	0.9
Delay disc. indifference point, 0s delay	1.0	1.1	2.2	0.1	1.0	1.1	-0.9	-1.3	-1.5	1.0
Delay disc. indifference point, 16s delay	0.7	1.0	1.7	-1.0	-1.3	-1.1	1.0	1.0	0.9	-0.4
Delay disc. indifference point, 2s delay	0.7	0.7	1.4	-0.8	-1.2	-0.9	1.0	0.8	0.7	-0.5
Delay disc. indifference point, 24s delay	0.0	0.1	0.2	-0.4	-0.0	-0.1	0.1	0.1	-0.0	0.4
Delay disc. indifference point, 4s delay	0.2	0.2	0.5	0.4	0.1	-0.3	0.3	0.4	0.6	0.7
Delay disc. indifference point, 8s delay	0.8	1.3	3.4	-1.8	-0.9	-1.2	1.2	1.1	0.8	-0.3
Indifference point function ln k	0.7	2.1	3.2	-0.9	-1.1	-1.6	1.8	1.7	1.6	-1.1
Indifference point function log k	0.7	2.1	3.2	-0.9	-1.1	-1.6	1.8	1.7	1.6	-1.1
Patch foraging total patch changes 0 sec	0.6	1.9	3.4	-1.3	-0.8	-1.5	1.8	1.6	1.5	-0.2
Patch foraging total patch changes 12 sec	0.9	1.2	3.0	1.0	1.7	1.0	-0.8	-0.7	-0.6	1.5
Patch foraging total patch changes 18 sec	1.0	2.3	4.2	1.9	2.0	1.6	-1.3	-1.2	-1.0	1.2
Patch foraging total patch changes 24 sec	0.2	0.8	2.4	0.3	1.3	0.7	-0.6	-0.6	-0.6	1.6
Patch foraging total patch changes 6 sec	0.1	0.2	0.6	-0.0	0.8	0.4	-0.2	-0.2	-0.2	0.7
Patch foraging time to switch 0 sec	0.0	0.1	0.2	-0.5	-0.1	0.1	-0.3	-0.1	-0.2	-0.3
Patch foraging water rate 0 sec	0.1	0.2	1.0	0.4	0.3	0.2	0.1	-0.4	-0.3	1.0
Patch foraging water rate 12 sec	0.1	0.6	1.2	1.1	0.6	0.6	-0.9	-0.7	-0.6	0.6
Patch foraging water rate 18 sec	1.1	2.4	4.5	0.8	0.8	1.6	-1.8	-1.9	-2.1	1.2
Patch foraging water rate 24 sec	0.0	0.1	0.2	0.5	-0.1	0.1	-0.3	-0.2	-0.1	0.1
Patch foraging water rate 6 sec	3.0	4.5	8.3	2.9	2.1	2.0	-1.8	-2.0	-1.6	2.2
Seeking ratio, delayed vs. immediate footshock	3.6	5.2	6.7	-1.9	-2.0	-2.5	2.5	2.6	2.5	-1.7
Distance traveled before self-admin	1.5	3.2	4.4	-2.1	-1.7	-1.8	1.7	1.7	1.4	-2.0
Distance traveled after self-admin	0.4	0.7	2.7	-1.0	-0.8	-0.2	0.2	-0.1	-0.3	-1.6
Extensor digitorum longus weight	0.2	0.7	2.1	0.0	-0.1	0.7	-0.8	-0.9	-0.9	-1.5
Bone: elastic displacement	0.1	0.1	0.4	0.5	0.2	0.3	-0.2	-0.2	0.0	0.7
Bone: elastic work	0.0	0.0	0.1	0.2	-0.1	0.3	-0.2	-0.2	-0.2	0.1
Bone: endosteal estimation	0.0	0.0	0.1	-0.1	-0.0	-0.3	0.2	0.2	0.2	0.1
Bone: endosteal perimeter	0.1	0.3	0.7	-0.1	-0.1	-0.9	0.6	0.8	0.8	0.1
Epididymis fat weight	0.2	1.0	3.0	-1.7	-0.8	-0.9	1.1	0.8	0.5	-0.2
Delta time in closed arm before/after self-admin	0.4	0.4	0.6	-0.5	-0.5	-0.6	0.7	0.8	0.7	-0.1
Delta time in open arm before/after self-admin	0.7	0.9	1.3	1.1	1.0	0.9	-0.9	-0.9	-0.8	0.8
Diff in mean of infusions in LGA sessions	0.2	0.4	1.6	1.2	0.6	-0.1	-0.0	0.4	0.7	0.7
Delay discount exponential model param	0.3	0.4	0.6	0.7	0.6	0.8	-0.8	-0.7	-0.6	-0.0
Extinction: sum of active levers before priming	2.8	4.2	5.4	-1.5	-2.3	-2.3	1.9	2.2	2.2	-1.8
Active lever presses in extinction session 6	0.1	0.1	0.3	0.3	-0.4	0.0	-0.0	0.2	0.2	-0.6
Bone: final force	1.0	1.6	3.8	0.3	0.6	1.5	-1.3	-1.7	-2.0	-0.2
Bone: final moment	0.6	1.0	2.6	-0.0	0.3	1.2	-1.0	-1.4	-1.6	-0.4
Food consumed during 24 hour testing period	3.6	7.3	8.8	2.9	3.0	2.9	-2.6	-2.7	-2.5	2.3
Glucose	0.2	0.3	0.6	-0.3	0.1	0.4	-0.2	-0.6	-0.8	0.7
Heart weight	1.1	1.8	3.3	-0.5	-0.9	-1.7	1.4	1.7	1.8	-0.8
Delay discount hyperbolic model param	0.3	0.4	0.6	0.7	0.6	0.8	-0.8	-0.7	-0.6	-0.1
Intermittent access intake day 1-15 change	1.1	5.8	7.5	1.8	2.7	2.6	-2.3	-2.5	-2.6	2.2
Intermittent access intake escalation	0.8	4.5	5.8	1.6	2.4	2.3	-2.0	-2.2	-2.2	2.0
Intermittent access intake escalation 2	2.1	3.5	5.9	1.4	2.4	1.9	-1.7	-1.7	-1.7	2.1
Intermitt. access day 1 inactive lever presses	0.0	0.1	0.3	-0.1	-0.3	-0.2	0.2	0.3	0.3	-0.5
Intermitt. access day 15 inactive lever presses	0.2	0.9	1.7	-0.4	-0.7	-1.0	0.9	1.3	1.3	-0.8
Intermitt. access escalation Index	0.1	0.3	0.6	-0.0	-0.4	-0.6	0.5	0.7	0.8	-0.2
Intermittent access day 1 total infusions	0.7	2.1	3.3	-1.8	-1.8	-1.6	1.3	1.3	1.2	-0.9
Intermittent access day 15 total infusions	0.0	0.0	0.2	-0.4	-0.1	-0.1	0.0	-0.1	-0.1	0.2
Intermittent access terminal intake (last 3 days)	0.1	0.1	0.2	-0.4	-0.2	-0.4	0.3	0.3	0.3	0.3
Intermittent access total infusions	0.1	0.1	0.3	-0.6	-0.2	-0.2	0.0	-0.0	-0.1	0.4
Intermittent access day 1 locomotion	0.1	0.2	0.8	-0.4	-0.9	-0.3	-0.0	0.0	0.0	-0.5
Intermittent access day 15 total locomotion	0.1	0.2	0.6	-0.8	-0.8	-0.2	0.3	-0.1	-0.2	-0.2
Intermittent access total locomotion	0.2	0.2	1.2	-1.1	-0.5	-0.2	0.2	-0.2	-0.4	0.1
Intermittent access standard deviation	0.3	1.6	2.2	0.9	1.5	1.3	-1.4	-1.2	-1.2	1.2
Left kidney weight	0.5	3.9	6.1	1.0	1.7	2.3	-2.2	-2.4	-2.5	1.1
Right kidney weight	0.2	1.2	2.5	-0.9	0.8	1.1	-0.9	-1.2	-1.6	0.8
Cocaine induced anxiety	0.3	0.9	1.5	-0.8	-0.2	-1.0	1.2	1.2	1.2	0.4
Post-drug Anxiety	0.5	0.5	1.0	-0.4	-0.2	-0.8	0.9	1.0	1.0	-0.0
Baseline Anxiety	0.2	0.4	0.6	0.6	0.3	0.6	-0.8	-0.8	-0.7	-0.5
Tail length	0.6	3.4	4.3	1.7	2.1	1.9	-1.6	-2.0	-1.9	1.7
Length with tail	0.2	0.8	2.1	-0.5	0.5	1.0	-0.8	-1.2	-1.5	0.6
Length without tail	0.2	1.0	4.3	-2.1	-1.3	-0.4	0.6	0.3	-0.1	-0.8
Times rat made contact with spout	0.1	0.1	0.2	0.3	0.1	0.3	-0.2	-0.3	-0.3	-0.4
Lifetime Intake	0.1	0.1	0.6	-0.5	0.0	-0.1	-0.1	-0.1	-0.2	0.8
Liver weight, left	0.1	0.2	0.3	-0.5	0.3	0.3	0.0	-0.3	-0.5	0.5
Liver weight, right	0.3	0.5	2.5	-1.6	-0.4	0.4	0.0	-0.5	-0.9	-0.0
Locomotor activity	0.4	0.6	1.3	-1.1	-1.1	-0.6	0.7	0.5	0.4	-0.6
Locomotor testing distance	0.2	0.4	0.7	-0.5	-0.8	-0.7	0.7	0.6	0.7	-0.4
Locomotor testing rearing	0.2	0.7	2.0	0.6	1.1	0.7	-0.5	-0.6	-0.5	1.4
Locomotion in novel chamber	0.5	0.7	3.2	-1.8	-0.7	-0.5	0.6	0.5	0.2	-0.0
Locomotion in novel chamber post-restriction	0.2	0.7	1.5	0.4	0.2	0.8	-1.2	-1.0	-1.1	0.5
Fecal boli incidents, locomotor time 1	0.5	1.4	3.1	1.0	1.8	1.1	-1.0	-1.0	-0.9	1.2
Change in fecal boli incidents, locomotor task	0.1	0.1	0.2	0.4	0.1	-0.1	0.2	0.3	0.4	0.5
Time >=10cm from walls, locomotor time 1	0.3	0.3	0.7	-0.8	-0.0	0.4	-0.6	-0.6	-0.8	0.1
Bouts of movement, locomotor time 1	0.8	1.0	3.8	1.9	0.9	0.9	-0.7	-0.7	-0.4	0.5
Total resting periods, locomotor time 1	0.6	0.7	3.6	1.9	0.7	0.6	-0.5	-0.3	0.0	0.2
Rest time, locomotor task time 1	0.5	0.8	2.6	1.6	1.0	0.8	-0.9	-0.6	-0.3	-0.2
Distance moved, locomotor task time 1	0.2	0.6	1.2	-0.7	-1.1	-0.8	0.8	0.8	0.8	0.1
Vertical activity count, locomotor time 1	0.1	0.5	1.0	-0.2	0.3	0.8	-0.7	-0.8	-1.0	0.7
Time >=10cm from walls, locomotor time 2	0.2	0.5	1.6	-1.3	-0.7	-0.4	0.6	0.2	-0.1	-0.8
Bouts of movement, locomotor time 2	0.1	0.2	0.5	0.7	-0.5	-0.3	0.4	0.4	0.6	-0.2
Total resting periods, locomotor time 2	0.1	0.2	1.3	1.1	-0.1	-0.1	0.2	0.3	0.6	-0.0
Rest time, locomotor task time 2	0.7	1.2	6.6	2.6	1.0	0.3	-0.5	-0.0	0.6	-0.1
Distance moved, locomotor task time 2	1.7	2.3	7.7	-2.8	-1.9	-1.2	1.3	1.0	0.5	-0.6
Vertical activity count, locomotor time 2	0.4	0.9	3.1	-1.8	0.3	0.6	-0.2	-0.8	-1.3	0.9
Light reinforcement 1	5.5	25.0	28.1	4.3	5.2	5.3	-5.2	-5.2	-5.0	4.7
Light reinforcement 2	6.0	13.7	16.0	3.8	4.0	3.7	-3.8	-3.8	-3.5	3.3
Bone: marrow area	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.3	0.3	0.3	0.1
Bone: maximum diameter	0.3	0.6	1.0	-1.0	-0.7	-0.9	0.5	0.8	0.6	-0.8
Bone: maximum force	0.2	0.3	0.5	0.5	0.1	0.6	-0.5	-0.7	-0.7	-0.6
Bone: maximum moment	0.1	0.2	0.5	0.2	-0.2	0.3	-0.2	-0.4	-0.4	-0.7
Mean time between licks in bursts	0.1	0.4	2.2	-1.5	-0.3	-0.6	-0.1	0.5	0.3	-0.0
Mean num. licks in bursts	0.2	0.5	2.2	0.1	-0.6	-0.5	0.5	0.5	0.5	-1.5
Cd content in liver	1.1	1.2	2.9	0.0	-0.4	-1.2	1.2	1.5	1.7	0.2
Co content in liver	1.1	1.2	1.8	-1.3	-0.8	-1.3	0.9	1.3	1.2	-0.7
Cu content in liver	0.1	0.1	0.5	-0.7	-0.1	0.3	-0.1	-0.3	-0.5	0.2
Fe content in liver	1.7	2.1	4.6	0.4	0.6	1.8	-1.6	-1.9	-2.2	-0.6
K content in liver	1.1	1.1	2.9	-1.7	-1.5	-0.4	0.5	0.4	0.1	-1.4
Mg content in liver	0.7	0.8	2.2	-1.5	-1.1	-0.5	0.8	0.6	0.4	-0.9
Mn content in liver	0.6	0.6	1.7	0.1	-0.3	-0.8	0.8	1.0	1.3	-0.4
Na content in liver	0.4	0.4	0.9	-0.9	-0.6	0.3	-0.3	-0.5	-0.8	-1.0
Rb content in liver	0.6	0.7	1.4	0.2	0.7	1.2	-0.6	-1.0	-1.1	0.4
Se content in liver	1.8	2.2	4.3	0.4	0.8	1.8	-1.7	-1.9	-2.1	-0.6
Sr content in liver	0.4	0.4	1.1	-1.1	-0.7	-0.6	0.3	0.5	0.3	-0.4
Zn content in liver	1.9	2.2	3.6	-1.3	-1.2	-1.6	1.9	1.6	1.5	-0.9
Bone: minimum diameter	0.9	1.6	2.6	1.2	1.2	1.4	-1.6	-1.4	-1.4	0.3
Time in familiar zone, hab. session 1	0.7	0.7	1.3	0.1	0.9	0.8	-1.2	-0.9	-1.1	0.6
Time in novel zone, hab. session 1	0.6	0.7	1.5	0.2	-1.0	-0.7	0.8	0.7	1.0	-1.2
Total zone transitions, hab. session 1	0.2	0.2	0.3	-0.5	-0.0	-0.6	0.6	0.6	0.5	0.1
Total locomotion distance, hab. session 1	0.4	0.5	1.1	0.1	-0.3	-0.8	0.9	0.9	1.0	-0.3
Locomotion velocity, hab. session 1	0.3	0.5	1.0	-0.0	-0.2	-0.8	1.0	0.9	1.0	0.1
Time in familiar zone, hab. session 2	1.6	1.8	3.3	1.6	1.8	1.1	-1.2	-1.0	-0.8	1.7
Time in novel zone, hab. session 2	2.8	3.0	4.7	-1.4	-1.9	-1.6	1.7	1.6	1.6	-2.2
Total zone transitions, hab. session 2	0.0	0.1	0.2	0.2	0.3	0.0	0.3	0.1	0.2	0.5
Total locomotion distance, hab. session 2	0.1	0.2	0.3	0.4	0.3	-0.2	0.6	0.3	0.5	0.5
Locomotion velocity, hab. session 2	0.1	0.1	0.5	0.5	0.4	0.1	0.3	-0.0	0.1	0.7
Novel to familiar place preference ratio	1.0	1.3	2.1	-0.6	-1.4	-1.1	1.2	1.1	1.2	-1.2
Novelty place preference	0.8	1.0	1.7	-0.3	-1.3	-1.0	1.1	1.0	1.1	-1.1
Time in novel zone, NPP test	1.0	1.2	2.1	-0.6	-1.4	-1.0	1.0	0.9	0.9	-1.4
Total zone transitions, NPP test	0.1	0.1	0.5	-0.7	0.4	-0.0	0.2	0.0	-0.2	0.4
Total locomotion distance, NPP test	0.1	0.1	0.3	-0.4	-0.1	-0.3	0.5	0.3	0.3	-0.6
Locomotion velocity, NPP test	0.0	0.0	0.1	-0.1	0.3	-0.0	0.2	0.0	0.0	-0.1
Intraocular pressure	3.3	5.4	9.0	-1.2	-1.8	-2.8	2.6	2.9	3.0	-1.2
Delta distance traveled before/after self-admin	2.0	2.2	3.9	0.9	1.1	1.7	-1.6	-1.9	-2.0	0.5
Delta ambulatory time before/after self-admin	2.3	4.0	6.1	1.2	1.9	2.3	-2.1	-2.4	-2.5	1.2
Parametrial fat weight	0.1	0.3	1.1	-0.7	0.5	-0.0	0.2	-0.0	-0.1	1.0
Pavlov. Cond. lever latency	0.0	0.1	0.2	0.1	0.2	-0.2	0.0	0.1	0.3	0.5
Pavlov. Cond. magazine entry latency	0.1	0.2	1.3	-0.1	-0.1	-0.0	-0.1	0.1	0.0	-1.1
Pavlov. Cond. change in total contacts	0.6	0.7	1.3	0.5	0.7	1.0	-0.7	-1.0	-1.1	-0.5
Pavlov. Cond. index score	0.2	0.3	1.3	-0.5	-0.5	-0.2	0.2	0.2	0.1	-1.1
Pavlov. Cond. latency score	0.1	0.1	0.8	-0.2	-0.2	-0.2	0.1	0.2	0.2	-0.9
Pavlov. Cond. lever contacts	0.1	0.1	0.6	-0.4	-0.4	-0.0	0.2	0.1	-0.1	-0.8
Pavlov. Cond. magazine entry number	0.5	0.6	2.4	1.1	0.6	0.2	-0.1	-0.1	0.2	1.5
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.4	-0.3	-0.3	-0.3	0.3	0.3	0.3	0.6
Pavlov. Cond. lever-magazine prob. diff.	0.3	0.4	1.5	-0.7	-0.6	-0.3	0.3	0.4	0.2	-1.2
Pavlov. Cond. response bias	0.4	0.5	2.0	-0.9	-0.6	-0.1	0.0	-0.0	-0.4	-1.4
Pavlov. Cond. lever latency	0.2	0.3	0.6	0.6	-0.5	-0.4	0.8	0.5	0.8	-0.4
Pavlov. Cond. magazine entry latency	0.1	0.2	0.5	-0.7	0.3	0.1	-0.4	-0.2	-0.4	0.7
Pavlov. Cond. change in total contacts	0.1	0.3	1.6	-1.3	-0.1	0.0	-0.2	-0.2	-0.5	0.2
Pavlov. Cond. index score	0.2	0.2	1.2	-1.1	0.0	0.1	-0.4	-0.2	-0.5	0.2
Pavlov. Cond. latency score	0.1	0.2	0.8	-0.9	0.1	0.2	-0.5	-0.3	-0.5	0.2
Pavlov. Cond. lever contacts	0.5	0.7	1.2	-0.5	0.7	0.7	-1.0	-0.8	-1.1	0.7
Pavlov. Cond. magazine entry number	0.1	0.1	0.7	0.9	0.1	0.1	0.1	-0.0	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.7	1.3	0.9	1.1	-0.6	-0.9	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.3	1.4	-1.2	0.0	0.0	-0.3	-0.2	-0.5	0.2
Pavlov. Cond. response bias	0.3	0.4	1.4	-1.2	0.2	0.2	-0.6	-0.4	-0.8	0.5
Time in closed arm before self-admin	1.9	3.3	4.9	1.0	1.7	2.0	-2.2	-2.1	-2.2	0.9
Time in closed arm after self-admin	1.1	1.2	1.6	0.8	1.2	1.2	-1.2	-1.1	-1.2	0.7
Time in open arm before self-admin	1.3	1.6	2.2	-1.5	-1.3	-1.4	1.4	1.4	1.2	-0.4
Time in open arm after self-admin	0.9	1.0	1.6	-1.1	-1.3	-1.1	1.1	0.9	0.9	-0.7
Bone: periosteal estimation	0.0	0.1	0.2	0.3	0.3	0.2	-0.4	-0.3	-0.3	-0.1
Bone: periosteal perimeter	0.1	0.2	0.5	-0.1	-0.1	-0.7	0.5	0.7	0.7	-0.2
Bone: post-yield work	0.3	0.5	0.8	0.6	-0.1	-0.8	0.8	0.7	0.9	-0.7
Progressive ratio test 1 active lever presses	0.2	0.3	1.2	-1.1	-0.5	-0.1	0.0	-0.3	-0.5	0.2
Progressive ratio test 1 breakpoint	0.2	0.3	1.3	-1.1	-0.5	-0.1	0.0	-0.3	-0.5	0.1
Progressive ratio test 1 inactive lever presses	0.1	0.3	1.3	-1.2	-0.6	-0.3	0.1	0.1	-0.1	-0.6
Progressive ratio test 2 active lever presses	0.1	0.1	0.4	-0.6	-0.4	-0.1	-0.1	-0.1	-0.2	-0.0
Progressive ratio test 2 breakpoint	0.1	0.1	0.4	-0.6	-0.5	-0.2	0.0	0.0	-0.0	-0.1
Progressive ratio test 2 inactive lever presses	0.4	1.3	1.7	-1.1	-1.0	-1.3	1.2	1.3	1.2	-0.4
Incentive Sensitization - Responses	0.0	0.0	0.2	0.1	0.0	0.0	0.0	0.0	0.1	0.4
Incentive Sensitization - Breakpoint	0.0	0.1	0.3	0.3	0.1	0.1	-0.0	-0.0	0.1	0.5
Sum of active levers in priming session hrs 5-6	0.3	0.3	0.5	0.4	-0.4	-0.4	0.7	0.6	0.7	-0.2
Progressive ratio	0.2	0.6	2.6	1.6	0.9	0.4	-0.2	-0.4	-0.0	0.2
Food seeking constrained by brief footshock	2.1	2.6	4.3	2.1	1.8	1.6	-1.3	-1.4	-1.3	1.8
Seeking ratio, punishment vs. effort	0.5	1.1	2.2	-0.2	0.5	1.2	-1.1	-1.2	-1.5	1.0
Retroperitoneal fat weight	0.2	0.7	1.2	-0.9	-0.1	-0.9	1.1	1.0	1.1	0.3
Reaction time number correct	0.3	0.9	1.3	-0.8	-0.9	-1.0	1.1	1.1	1.0	-0.8
Reaction time mean minus median	0.4	2.5	5.6	-1.9	-2.4	-1.1	1.3	1.0	0.7	-2.1
Reaction time mean minus median AUC	0.3	2.1	4.3	-1.7	-1.9	-1.1	1.1	1.0	0.8	-2.1
Reaction time num false alarms	3.2	5.4	9.1	-3.0	-1.5	-2.6	2.6	2.6	2.3	-0.8
Reaction time num false alarms AUC	2.1	4.8	7.3	-2.7	-1.5	-2.5	2.5	2.5	2.2	-0.7
Reaction time trials correct on left	0.3	0.9	1.3	-0.8	-0.9	-1.0	1.1	1.1	1.0	-0.8
Reaction time trials on left	0.3	1.1	1.5	-1.0	-1.0	-1.1	1.2	1.2	1.1	-0.8
Reaction time mean	1.7	3.9	6.3	-2.5	-2.5	-1.7	1.6	1.5	1.2	-2.3
Reaction time mean AUC	1.6	3.8	6.3	-2.5	-2.5	-1.7	1.7	1.5	1.3	-2.2
Median of all reaction times	1.9	3.0	5.0	-2.2	-2.1	-1.6	1.4	1.4	1.1	-1.9
Reaction time omissions	2.2	3.6	7.6	-2.8	-2.3	-1.8	1.7	1.6	1.3	-1.4
Reaction time false alarm rate	1.3	1.8	3.7	-1.9	-0.6	-1.6	1.4	1.5	1.3	-0.1
Reaction time premature initiation rate	3.6	5.6	8.1	2.2	2.8	2.1	-2.5	-2.0	-1.9	2.7
Reaction time premature initiations	0.8	2.4	3.8	1.5	2.0	1.3	-1.6	-1.2	-1.1	1.9
Std. dev. reaction times	0.7	2.4	4.6	-2.1	-2.1	-1.2	1.4	1.1	0.8	-1.8
Reaction time trials completed	0.3	1.1	1.5	-1.0	-1.0	-1.1	1.2	1.2	1.1	-0.8
Reaction time trials AUC	0.3	1.2	1.6	-1.0	-1.0	-1.1	1.3	1.2	1.1	-0.8
Run reversals in cocaine runway, females	0.5	0.5	1.1	-1.0	-0.8	-0.6	1.0	0.5	0.3	-0.6
Run reversals in cocaine runway, males	0.2	0.2	0.5	-0.1	-0.7	-0.2	0.6	0.3	0.4	-0.7
Latency to leave start box in cocaine runway	0.2	0.3	0.6	0.1	-0.3	-0.6	0.8	0.6	0.8	0.4
Latency to leave start box in cocaine runway, F	0.7	0.9	1.4	-0.1	-1.2	-0.9	1.0	0.9	1.1	-1.2
Latency to leave start box in cocaine runway, M	1.2	1.1	5.5	0.5	1.3	0.4	-0.1	-0.3	-0.2	2.3
Std. dev. time between licks in bursts	0.2	0.4	1.0	0.0	0.5	0.7	-1.0	-0.6	-0.7	0.6
Total sessions with >9 infusions	0.1	0.1	0.2	-0.5	-0.4	-0.2	-0.0	-0.1	-0.2	0.5
Short access day 1 total inactive lever presses	0.1	0.2	0.8	-0.9	-0.1	0.2	-0.1	-0.5	-0.7	0.2
Short access day 10 total inactive lever presses	0.0	0.3	0.5	0.0	0.4	0.6	-0.6	-0.6	-0.7	0.7
Short access day 1 total infusions	0.4	0.7	1.3	-1.1	-0.9	-0.9	0.9	0.8	0.7	-0.1
Short access day 10 total infusions	0.0	0.0	0.2	-0.0	-0.2	0.0	-0.2	-0.1	-0.1	0.5
Short access total infusions	0.1	0.1	0.5	-0.7	-0.2	-0.3	0.1	0.1	-0.0	0.5
Short access day 1 locomotion	1.3	2.1	2.8	-1.1	-1.7	-1.6	1.5	1.6	1.6	-1.2
Short access day 10 total locomotion	0.0	0.1	0.2	-0.3	-0.5	-0.4	0.3	0.2	0.2	-0.0
Short access total locomotion	0.3	0.5	0.7	-0.5	-0.8	-0.8	0.7	0.7	0.7	-0.2
One hour access (0.3 mA shock)	0.3	0.4	1.0	0.2	0.0	-0.6	0.7	0.8	1.0	0.5
Compulsive drug intake	0.4	0.6	2.2	1.5	0.3	-0.2	0.6	0.6	1.0	-0.7
One hour access (shock baseline)	0.1	0.2	0.3	-0.3	-0.2	-0.5	0.5	0.5	0.6	0.5
Social response proportion	0.1	0.2	0.4	-0.6	-0.3	0.2	-0.4	-0.3	-0.4	-0.4
Social responses	0.1	0.2	0.7	-0.4	0.2	-0.3	0.1	0.4	0.3	0.8
Social time	1.0	1.6	3.4	1.4	0.8	1.3	-1.8	-1.3	-1.1	0.6
Soleus weight	0.0	0.1	0.3	0.2	0.2	-0.5	-0.3	0.4	0.5	-0.0
Bone: stiffness	0.1	0.2	0.7	-0.3	-0.3	0.1	0.1	-0.4	-0.5	-0.8
Tibialis anterior weight	0.5	1.8	4.5	-1.2	-1.3	-1.2	1.1	1.1	1.0	-2.1
Time to tail flick, vehicle, before self-admin	0.4	0.5	2.3	1.5	0.2	-0.2	0.1	0.3	0.7	0.5
Time to tail flick, vehicle, after self-admin	0.5	0.9	3.1	1.8	1.3	0.6	-0.7	-0.4	-0.1	0.8
Time to tail flick, test, before self-admin	0.9	1.0	2.3	-0.6	-0.4	-1.3	1.5	1.1	1.2	0.2
Time to tail flick, test, after self-admin	0.6	0.6	1.3	1.1	0.4	0.8	-0.8	-0.8	-0.7	-0.5
Delta time to tail flick, vehicle, before/after SA	0.3	0.3	0.8	0.4	0.9	0.5	-0.5	-0.5	-0.5	0.5
Delta time to tail flick, test, before/after SA	1.1	1.3	2.4	0.3	-0.2	1.2	-1.4	-1.4	-1.6	-1.1
Tibia length	0.6	1.7	4.8	-2.2	-1.8	-0.6	0.8	0.1	-0.4	-1.5
Ambulatory time before self-admin	1.2	3.7	4.3	-2.1	-1.8	-2.0	1.8	1.9	1.7	-2.1
Ambulatory time after self-admin	0.3	0.4	0.9	-0.3	0.1	0.6	-0.5	-0.8	-0.9	-0.9
Bone: tissue strength	0.2	0.2	0.5	-0.3	-0.2	0.4	-0.7	-0.5	-0.5	-0.5
Total heroin consumption	0.2	0.2	0.3	-0.5	-0.1	-0.5	0.5	0.5	0.5	-0.2
Bone: trabecular number	1.7	3.2	12.1	3.5	1.5	1.7	-1.5	-1.4	-0.8	-0.0
Bone: trabecular spacing	0.8	1.2	4.7	-2.2	-1.0	-0.9	0.7	0.9	0.6	0.2
Bone: trabecular thickness	2.4	3.3	6.6	2.6	1.6	2.0	-1.8	-2.0	-1.7	0.1
Bone: trabecular tissue density	0.4	0.7	1.7	-1.1	-0.7	-0.9	1.3	0.8	0.6	0.2
Water consumed over 24 hours	1.4	2.8	3.7	1.6	1.7	1.8	-1.9	-1.8	-1.7	0.9
Number of responses in last shaping day	1.3	1.7	2.6	-0.8	-1.1	-1.4	1.4	1.6	1.6	-0.9