Hub : Genes

LOC102556644

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS XR_590754.4 0.04 0.02 3.2e-03 0.01 0 0.01 0 5.8e-02 7.4e-02 2.0e-02 8.3e-02
2 Adipose alternative TSS XR_010063321.1 0.03 0.02 3.7e-03 0.01 0 0.01 0 6.2e-02 1.1e-01 3.5e-02 8.9e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density2.13.84.02.0-1.9
Area under the delay curve0.60.80.90.9-1.0
BMI with tail8.730.330.55.5-5.5
BMI without tail2.814.915.03.9-3.8
Body weight7.733.833.95.8-5.8
Weight adjusted by age2.47.07.22.7-2.6
Bone surface1.22.42.61.6-1.5
Bone volume2.95.96.02.4-2.4
Breakpoint value in progressive ratio session1.62.82.91.7-1.7
Number of licking bursts0.10.20.30.6-0.4
Context. condit. distance diff. score0.60.80.8-0.90.9
Locomotion velocity, session 10.10.10.1-0.40.3
Locomotion distance, session 10.50.70.7-0.80.8
Locomotion velocity, session 22.53.03.1-1.71.8
Locomotion distance, session 20.10.20.2-0.40.4
Locomotion velocity, session 30.91.01.0-1.01.0
Locomotion distance, session 32.32.72.7-1.61.6
Stereotopy head waving bouts, day 30.00.00.0-0.20.1
Stereotopy head waving duration, day 30.10.10.10.3-0.3
Locomotion velocity, session 70.40.50.50.7-0.6
Locomotion distance, session 70.00.00.00.00.0
Stereotopy head waving bouts, day 70.10.10.10.3-0.3
Stereotopy head waving duration, day 71.01.31.31.1-1.1
Locomotion velocity, session 82.22.72.9-1.61.7
Locomotion distance, session 82.53.63.9-1.82.0
Degree of sensitization distance1.61.81.81.3-1.3
Degree of sensitization stereotypy0.60.60.70.8-0.8
Conditioned locomotion0.20.20.20.4-0.5
Cocaine response after cond. corrected3.45.15.2-2.32.2
Cocaine response after cond. not corrected3.85.55.5-2.42.3
Cocaine response before conditioning0.00.00.00.2-0.1
Saline control response0.30.40.5-0.70.6
Bone: connectivity density0.30.50.60.8-0.7
Bone: cortical apparent density2.64.24.2-2.02.1
Bone: cortical area8.513.914.53.8-3.6
Bone: cortical porosity0.00.00.0-0.20.1
Bone: cortical porosity0.20.20.20.4-0.5
Bone: cortical thickness2.54.14.52.1-1.9
Bone: cortical thickness1.11.41.41.2-1.2
Bone: cortical tissue density3.04.84.8-2.22.2
Condit. Reinf. active minus inactive responses2.12.32.5-1.51.6
Condit. Reinf. active-inactive response ratio0.90.91.0-0.91.0
Condit. Reinf. active responses0.40.50.6-0.60.8
Condit. Reinf. inactive responses0.10.20.20.5-0.4
Incentive salience index mean3.03.94.1-1.92.0
Condit. Reinf. lever presses1.82.72.7-1.61.7
Condit. Reinf. active minus inactive responses2.74.14.12.0-2.0
Condit. Reinf. active-inactive response ratio1.82.93.01.7-1.7
Condit. Reinf. active responses4.56.46.52.5-2.5
Condit. Reinf. inactive responses0.81.21.21.1-1.1
Condit. Reinf. lever presses2.02.92.91.7-1.7
Condit. Reinf. lever reinforcers received3.44.84.92.2-2.2
Conditioned reinforcement - actives0.10.40.4-0.60.6
Conditioned reinforcement - inactives0.51.31.31.1-1.1
Conditioned locomotion0.71.01.0-1.01.0
Patch foraging indifference point 0 sec1.54.34.52.1-2.0
Patch foraging indifference point AUC1.43.33.31.8-1.8
Delay disc. indifference point, 0s delay0.20.30.30.5-0.5
Delay disc. indifference point, 16s delay0.10.20.20.4-0.5
Delay disc. indifference point, 2s delay0.30.40.5-0.70.5
Delay disc. indifference point, 24s delay0.40.60.60.7-0.8
Delay disc. indifference point, 4s delay0.00.10.1-0.30.2
Delay disc. indifference point, 8s delay2.74.44.52.1-2.1
Indifference point function ln k0.31.01.0-1.01.0
Indifference point function log k0.31.01.0-1.01.0
Patch foraging total patch changes 0 sec1.95.55.82.4-2.3
Patch foraging total patch changes 12 sec3.64.84.92.2-2.2
Patch foraging total patch changes 18 sec5.112.012.23.5-3.4
Patch foraging total patch changes 24 sec2.37.87.92.8-2.8
Patch foraging total patch changes 6 sec6.410.811.13.3-3.2
Patch foraging time to switch 0 sec0.31.11.1-1.11.0
Patch foraging water rate 0 sec0.31.01.11.0-1.0
Patch foraging water rate 12 sec1.35.45.62.4-2.3
Patch foraging water rate 18 sec0.00.10.10.3-0.3
Patch foraging water rate 24 sec0.40.50.50.7-0.7
Patch foraging water rate 6 sec0.60.90.90.9-1.0
Seeking ratio, delayed vs. immediate footshock4.46.36.3-2.52.5
Distance traveled before self-admin1.43.13.4-1.81.7
Distance traveled after self-admin1.73.03.2-1.81.7
Extensor digitorum longus weight1.14.24.52.0-2.1
Bone: elastic displacement0.00.00.0-0.1-0.0
Bone: elastic work0.00.00.0-0.10.1
Bone: endosteal estimation1.84.34.32.1-2.1
Bone: endosteal perimeter4.711.511.63.4-3.4
Epididymis fat weight9.447.647.76.9-6.9
Delta time in closed arm before/after self-admin1.71.61.7-1.31.2
Delta time in open arm before/after self-admin5.05.96.22.5-2.4
Diff in mean of infusions in LGA sessions0.00.00.00.0-0.1
Delay discount exponential model param0.50.70.8-0.70.9
Extinction: sum of active levers before priming0.10.10.20.3-0.4
Active lever presses in extinction session 60.00.00.0-0.10.1
Bone: final force2.64.24.42.1-2.0
Bone: final moment2.64.24.42.1-2.0
Food consumed during 24 hour testing period0.81.61.7-1.21.3
Glucose2.23.43.61.8-1.9
Heart weight2.23.53.71.9-1.8
Delay discount hyperbolic model param0.30.40.5-0.60.7
Intermittent access intake day 1-15 change0.20.90.90.9-1.0
Intermittent access intake escalation0.21.11.21.0-1.1
Intermittent access intake escalation 20.10.20.30.5-0.5
Intermitt. access day 1 inactive lever presses0.67.57.72.8-2.7
Intermitt. access day 15 inactive lever presses0.63.53.61.9-1.9
Intermitt. access escalation Index0.10.30.3-0.60.6
Intermittent access day 1 total infusions0.00.00.00.2-0.2
Intermittent access day 15 total infusions0.20.50.50.7-0.7
Intermittent access terminal intake (last 3 days)0.20.30.30.5-0.6
Intermittent access total infusions0.60.70.70.9-0.9
Intermittent access day 1 locomotion0.00.00.00.1-0.2
Intermittent access day 15 total locomotion1.45.35.52.3-2.4
Intermittent access total locomotion0.30.40.40.6-0.7
Intermittent access standard deviation0.52.82.91.7-1.7
Left kidney weight0.32.52.71.6-1.5
Right kidney weight0.96.16.52.5-2.4
Cocaine induced anxiety2.36.46.4-2.52.5
Post-drug Anxiety0.20.20.3-0.40.5
Baseline Anxiety3.05.15.22.3-2.2
Tail length0.00.10.10.4-0.4
Length with tail0.73.03.11.8-1.7
Length without tail1.910.010.23.2-3.1
Times rat made contact with spout0.00.10.1-0.20.2
Lifetime Intake0.50.60.60.8-0.8
Liver weight, left5.29.09.03.0-3.0
Liver weight, right0.81.31.41.2-1.1
Locomotor activity0.10.20.20.4-0.4
Locomotor testing distance0.00.00.00.0-0.0
Locomotor testing rearing0.10.50.50.7-0.7
Locomotion in novel chamber3.85.25.2-2.32.3
Locomotion in novel chamber post-restriction1.95.76.0-2.42.3
Fecal boli incidents, locomotor time 10.61.61.71.3-1.2
Change in fecal boli incidents, locomotor task2.83.03.1-1.71.7
Time >=10cm from walls, locomotor time 12.43.03.0-1.71.7
Bouts of movement, locomotor time 11.92.42.51.6-1.5
Total resting periods, locomotor time 11.01.21.31.1-1.1
Rest time, locomotor task time 10.10.10.10.4-0.2
Distance moved, locomotor task time 10.00.00.1-0.30.1
Vertical activity count, locomotor time 10.21.72.0-1.41.2
Time >=10cm from walls, locomotor time 20.20.50.6-0.70.8
Bouts of movement, locomotor time 20.10.20.3-0.50.4
Total resting periods, locomotor time 20.00.00.0-0.10.0
Rest time, locomotor task time 20.30.40.50.7-0.6
Distance moved, locomotor task time 20.00.10.10.2-0.2
Vertical activity count, locomotor time 20.00.00.0-0.10.1
Light reinforcement 10.41.81.8-1.31.3
Light reinforcement 21.84.04.1-2.02.0
Bone: marrow area1.74.34.32.1-2.1
Bone: maximum diameter8.517.017.34.2-4.1
Bone: maximum force1.22.42.61.6-1.5
Bone: maximum moment1.32.42.61.6-1.5
Mean time between licks in bursts0.00.00.0-0.10.1
Mean num. licks in bursts0.20.60.7-0.80.7
Cd content in liver3.74.14.2-2.02.0
Co content in liver0.30.40.4-0.60.7
Cu content in liver0.30.30.3-0.60.6
Fe content in liver1.31.61.61.3-1.3
K content in liver0.00.00.00.0-0.1
Mg content in liver0.00.10.10.1-0.3
Mn content in liver0.00.00.0-0.20.1
Na content in liver0.00.00.0-0.1-0.1
Rb content in liver0.10.10.1-0.30.2
Se content in liver0.50.60.6-0.70.8
Sr content in liver5.85.15.2-2.32.2
Zn content in liver1.82.12.4-1.51.4
Bone: minimum diameter4.48.58.83.0-2.9
Time in familiar zone, hab. session 10.30.40.4-0.60.5
Time in novel zone, hab. session 11.92.12.21.5-1.4
Total zone transitions, hab. session 10.30.50.50.7-0.7
Total locomotion distance, hab. session 10.00.00.0-0.10.1
Locomotion velocity, hab. session 10.10.20.2-0.40.5
Time in familiar zone, hab. session 21.21.41.51.2-1.1
Time in novel zone, hab. session 20.91.01.0-1.00.9
Total zone transitions, hab. session 20.60.70.80.8-0.9
Total locomotion distance, hab. session 20.00.00.00.2-0.2
Locomotion velocity, hab. session 20.00.00.00.2-0.2
Novel to familiar place preference ratio0.20.20.30.5-0.4
Novelty place preference0.20.20.20.5-0.4
Time in novel zone, NPP test0.81.01.01.0-0.9
Total zone transitions, NPP test0.10.10.10.4-0.3
Total locomotion distance, NPP test0.10.20.2-0.40.5
Locomotion velocity, NPP test0.71.01.1-1.01.1
Intraocular pressure3.76.06.12.5-2.4
Delta distance traveled before/after self-admin0.00.00.0-0.20.1
Delta ambulatory time before/after self-admin0.00.00.00.2-0.2
Parametrial fat weight21.450.551.37.2-7.0
Pavlov. Cond. lever latency1.01.21.31.1-1.1
Pavlov. Cond. magazine entry latency0.30.40.4-0.60.6
Pavlov. Cond. change in total contacts0.40.40.4-0.60.6
Pavlov. Cond. index score0.20.30.3-0.60.5
Pavlov. Cond. latency score0.20.30.3-0.50.5
Pavlov. Cond. lever contacts0.40.50.5-0.70.7
Pavlov. Cond. magazine entry number0.00.00.00.2-0.1
Pavlov. Cond. intertrial magazine entries0.50.60.7-0.70.8
Pavlov. Cond. lever-magazine prob. diff.0.30.40.4-0.60.6
Pavlov. Cond. response bias0.60.70.7-0.80.8
Pavlov. Cond. lever latency1.52.12.2-1.51.4
Pavlov. Cond. magazine entry latency1.01.41.51.2-1.2
Pavlov. Cond. change in total contacts1.33.33.31.8-1.8
Pavlov. Cond. index score2.03.13.11.8-1.7
Pavlov. Cond. latency score1.82.93.01.7-1.7
Pavlov. Cond. lever contacts1.01.51.61.3-1.2
Pavlov. Cond. magazine entry number1.41.81.9-1.31.4
Pavlov. Cond. intertrial magazine entries0.10.10.10.4-0.3
Pavlov. Cond. lever-magazine prob. diff.1.82.72.81.7-1.6
Pavlov. Cond. response bias1.92.72.81.7-1.6
Time in closed arm before self-admin0.00.10.1-0.30.3
Time in closed arm after self-admin2.32.62.7-1.61.6
Time in open arm before self-admin2.42.93.0-1.71.7
Time in open arm after self-admin1.51.61.71.3-1.2
Bone: periosteal estimation4.510.711.03.3-3.2
Bone: periosteal perimeter11.422.622.74.8-4.7
Bone: post-yield work0.00.00.10.3-0.1
Progressive ratio test 1 active lever presses0.10.10.20.4-0.4
Progressive ratio test 1 breakpoint0.00.10.10.3-0.3
Progressive ratio test 1 inactive lever presses0.10.40.40.6-0.6
Progressive ratio test 2 active lever presses1.52.12.21.5-1.5
Progressive ratio test 2 breakpoint1.72.22.21.5-1.5
Progressive ratio test 2 inactive lever presses1.34.14.22.1-2.0
Incentive Sensitization - Responses0.82.32.31.5-1.5
Incentive Sensitization - Breakpoint1.02.32.31.5-1.5
Sum of active levers in priming session hrs 5-60.10.10.10.3-0.3
Progressive ratio0.31.01.0-1.01.0
Food seeking constrained by brief footshock0.30.40.4-0.70.7
Seeking ratio, punishment vs. effort0.10.20.30.4-0.5
Retroperitoneal fat weight15.669.670.38.4-8.3
Reaction time number correct1.03.73.91.9-2.0
Reaction time mean minus median0.21.31.41.1-1.2
Reaction time mean minus median AUC0.10.40.50.5-0.7
Reaction time num false alarms0.40.70.7-0.80.8
Reaction time num false alarms AUC0.30.60.6-0.80.8
Reaction time trials correct on left1.03.73.91.9-2.0
Reaction time trials on left1.24.04.32.0-2.1
Reaction time mean0.00.10.10.2-0.4
Reaction time mean AUC0.00.00.10.0-0.2
Median of all reaction times0.00.00.1-0.30.1
Reaction time omissions1.42.32.51.4-1.6
Reaction time false alarm rate2.12.93.1-1.71.7
Reaction time premature initiation rate0.00.10.1-0.20.3
Reaction time premature initiations0.30.90.90.9-1.0
Std. dev. reaction times0.82.72.91.6-1.7
Reaction time trials completed1.24.04.32.0-2.1
Reaction time trials AUC1.13.94.11.9-2.0
Run reversals in cocaine runway, females0.10.10.10.3-0.2
Run reversals in cocaine runway, males0.60.70.7-0.90.8
Latency to leave start box in cocaine runway0.10.10.10.3-0.4
Latency to leave start box in cocaine runway, F0.00.00.0-0.0-0.1
Latency to leave start box in cocaine runway, M0.40.40.40.5-0.7
Std. dev. time between licks in bursts0.30.50.6-0.60.8
Total sessions with >9 infusions0.81.01.01.0-1.0
Short access day 1 total inactive lever presses0.00.00.0-0.10.1
Short access day 10 total inactive lever presses0.10.80.80.9-0.9
Short access day 1 total infusions0.00.00.00.2-0.2
Short access day 10 total infusions0.30.50.5-0.70.7
Short access total infusions0.00.00.00.00.0
Short access day 1 locomotion0.10.20.20.4-0.5
Short access day 10 total locomotion0.31.31.41.1-1.2
Short access total locomotion0.20.40.40.6-0.6
One hour access (0.3 mA shock)2.02.42.41.5-1.6
Compulsive drug intake0.00.10.10.2-0.3
One hour access (shock baseline)0.30.70.80.9-0.8
Social response proportion0.10.10.1-0.30.3
Social responses4.45.86.02.5-2.4
Social time0.30.40.50.6-0.7
Soleus weight1.64.65.22.0-2.3
Bone: stiffness1.32.32.51.6-1.4
Tibialis anterior weight0.92.93.31.6-1.8
Time to tail flick, vehicle, before self-admin0.40.50.60.8-0.6
Time to tail flick, vehicle, after self-admin0.00.00.10.2-0.2
Time to tail flick, test, before self-admin1.31.51.5-1.21.2
Time to tail flick, test, after self-admin1.81.92.01.4-1.3
Delta time to tail flick, vehicle, before/after SA0.70.70.80.8-0.9
Delta time to tail flick, test, before/after SA1.92.42.51.6-1.5
Tibia length0.30.80.91.0-0.9
Ambulatory time before self-admin0.41.11.2-1.11.0
Ambulatory time after self-admin0.81.41.5-1.21.1
Bone: tissue strength0.10.10.1-0.40.4
Total heroin consumption3.23.73.71.9-1.9
Bone: trabecular number1.12.12.31.5-1.4
Bone: trabecular spacing0.10.10.1-0.30.4
Bone: trabecular thickness5.57.67.72.8-2.8
Bone: trabecular tissue density0.20.40.4-0.70.5
Water consumed over 24 hours0.10.10.1-0.30.3
Number of responses in last shaping day0.00.00.0-0.10.1