LOC102554680

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver gene expression LOC102554680 0.04 0.03 5.7e-04 0.02 0.03 0.02 0.03 1.6e-03 5.3e-04 1.1e-03 8.0e-04
2 Adipose gene expression LOC102554680 0.07 0.04 1.4e-07 0.06 0.06 0.06 0.06 1.3e-07 4.4e-07 5.2e-07 5.3e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bone: apparent density0.40.71.5-0.1-1.2
Area under the delay curve1.92.02.11.5-1.4
BMI with tail0.10.20.3-0.30.6
BMI without tail0.10.20.20.5-0.4
Body weight0.00.10.20.2-0.4
Weight adjusted by age0.20.20.4-0.70.1
Bone surface0.30.51.1-0.1-1.0
Bone volume0.30.51.0-0.1-1.0
Breakpoint value in progressive ratio session0.91.01.5-1.20.7
Number of licking bursts0.40.40.5-0.7-0.6
Context. condit. distance diff. score0.00.00.0-0.2-0.1
Locomotion velocity, session 111.512.519.34.4-2.4
Locomotion distance, session 10.20.30.50.7-0.3
Locomotion velocity, session 26.37.39.33.1-2.3
Locomotion distance, session 20.30.40.80.9-0.2
Locomotion velocity, session 32.83.24.52.1-1.4
Locomotion distance, session 36.87.59.93.1-2.2
Stereotopy head waving bouts, day 36.17.210.5-3.21.9
Stereotopy head waving duration, day 31.01.21.81.3-0.7
Locomotion velocity, session 73.74.06.02.4-1.4
Locomotion distance, session 72.12.64.02.0-1.1
Stereotopy head waving bouts, day 70.40.40.50.6-0.7
Stereotopy head waving duration, day 73.84.65.22.3-2.0
Locomotion velocity, session 85.76.89.73.1-2.0
Locomotion distance, session 80.10.20.4-0.60.2
Degree of sensitization distance2.92.93.2-1.81.6
Degree of sensitization stereotypy3.03.23.61.9-1.7
Conditioned locomotion2.42.84.1-1.22.0
Cocaine response after cond. corrected0.60.61.20.3-1.1
Cocaine response after cond. not corrected0.60.71.00.6-1.0
Cocaine response before conditioning0.10.10.1-0.40.4
Saline control response0.60.81.30.5-1.2
Bone: connectivity density0.60.91.7-0.3-1.3
Bone: cortical apparent density0.60.81.5-0.21.2
Bone: cortical area0.30.40.7-0.1-0.9
Bone: cortical porosity0.70.71.11.1-0.6
Bone: cortical porosity0.30.30.50.7-0.4
Bone: cortical thickness0.00.00.1-0.1-0.3
Bone: cortical thickness0.20.20.30.6-0.2
Bone: cortical tissue density0.60.81.6-0.31.2
Condit. Reinf. active minus inactive responses2.12.43.0-1.31.7
Condit. Reinf. active-inactive response ratio1.01.11.8-1.30.6
Condit. Reinf. active responses2.53.14.0-1.52.0
Condit. Reinf. inactive responses0.50.61.1-0.01.1
Incentive salience index mean0.50.61.0-0.51.0
Condit. Reinf. lever presses0.81.01.91.4-0.4
Condit. Reinf. active minus inactive responses0.50.61.10.41.0
Condit. Reinf. active-inactive response ratio1.21.32.50.31.6
Condit. Reinf. active responses0.30.40.40.60.7
Condit. Reinf. inactive responses0.30.40.60.2-0.8
Condit. Reinf. lever presses0.71.01.21.10.9
Condit. Reinf. lever reinforcers received0.20.30.40.70.5
Conditioned reinforcement - actives1.61.63.2-0.11.8
Conditioned reinforcement - inactives1.51.61.8-1.21.3
Conditioned locomotion4.85.89.8-1.33.1
Patch foraging indifference point 0 sec0.50.81.2-0.61.1
Patch foraging indifference point AUC1.01.11.80.6-1.4
Delay disc. indifference point, 0s delay0.60.71.4-1.2-0.1
Delay disc. indifference point, 16s delay1.71.72.71.7-0.9
Delay disc. indifference point, 2s delay1.21.31.81.0-1.3
Delay disc. indifference point, 24s delay1.51.52.21.5-0.9
Delay disc. indifference point, 4s delay1.21.32.60.2-1.6
Delay disc. indifference point, 8s delay1.51.52.01.4-1.0
Indifference point function ln k0.71.01.91.40.0
Indifference point function log k0.71.01.91.40.0
Patch foraging total patch changes 0 sec0.40.71.3-0.31.1
Patch foraging total patch changes 12 sec1.41.93.3-1.80.6
Patch foraging total patch changes 18 sec2.53.24.0-2.01.5
Patch foraging total patch changes 24 sec1.72.12.4-1.61.3
Patch foraging total patch changes 6 sec0.10.20.3-0.1-0.6
Patch foraging time to switch 0 sec3.75.711.0-3.30.6
Patch foraging water rate 0 sec2.13.46.62.6-0.4
Patch foraging water rate 12 sec5.27.915.23.9-0.8
Patch foraging water rate 18 sec12.316.629.65.4-1.9
Patch foraging water rate 24 sec3.85.38.32.9-1.5
Patch foraging water rate 6 sec3.24.68.52.9-0.9
Seeking ratio, delayed vs. immediate footshock0.30.40.50.7-0.5
Distance traveled before self-admin0.50.51.1-1.0-0.1
Distance traveled after self-admin0.70.81.4-1.2-0.4
Extensor digitorum longus weight0.00.10.20.3-0.4
Bone: elastic displacement0.20.20.4-0.20.6
Bone: elastic work0.00.10.1-0.20.3
Bone: endosteal estimation0.41.01.80.4-1.3
Bone: endosteal perimeter0.10.30.4-0.3-0.7
Epididymis fat weight0.61.42.4-1.50.7
Delta time in closed arm before/after self-admin5.65.46.02.4-2.2
Delta time in open arm before/after self-admin0.00.00.0-0.10.1
Diff in mean of infusions in LGA sessions1.31.42.00.9-1.4
Delay discount exponential model param1.61.71.9-1.41.2
Extinction: sum of active levers before priming1.41.41.7-1.11.3
Active lever presses in extinction session 62.12.02.0-1.41.4
Bone: final force0.81.32.50.4-1.6
Bone: final moment0.61.01.80.3-1.4
Food consumed during 24 hour testing period2.42.94.91.0-2.2
Glucose0.30.40.80.9-0.2
Heart weight0.30.40.50.70.4
Delay discount hyperbolic model param1.61.71.9-1.21.4
Intermittent access intake day 1-15 change0.80.81.4-0.51.2
Intermittent access intake escalation1.41.42.6-0.51.6
Intermittent access intake escalation 21.41.42.4-0.61.5
Intermitt. access day 1 inactive lever presses4.85.16.61.9-2.6
Intermitt. access day 15 inactive lever presses0.60.70.80.8-0.9
Intermitt. access escalation Index0.60.51.00.3-1.0
Intermittent access day 1 total infusions2.63.04.4-1.22.1
Intermittent access day 15 total infusions4.55.18.3-1.32.9
Intermittent access terminal intake (last 3 days)6.77.411.1-1.93.3
Intermittent access total infusions5.35.88.6-1.72.9
Intermittent access day 1 locomotion0.10.10.20.50.2
Intermittent access day 15 total locomotion0.70.71.00.71.0
Intermittent access total locomotion0.30.30.50.20.7
Intermittent access standard deviation4.64.95.7-2.02.4
Left kidney weight1.74.76.5-2.61.7
Right kidney weight0.10.20.4-0.6-0.1
Cocaine induced anxiety1.11.32.00.8-1.4
Post-drug Anxiety1.31.51.81.1-1.3
Baseline Anxiety2.42.54.42.1-0.8
Tail length0.10.20.4-0.2-0.6
Length with tail0.10.51.10.1-1.0
Length without tail0.00.10.10.2-0.3
Times rat made contact with spout0.81.01.60.6-1.3
Lifetime Intake6.87.710.6-2.23.3
Liver weight, left0.50.71.4-1.2-0.2
Liver weight, right1.32.24.4-2.1-0.0
Locomotor activity3.04.87.42.7-1.5
Locomotor testing distance0.91.42.91.7-0.1
Locomotor testing rearing0.50.81.61.3-0.0
Locomotion in novel chamber1.92.32.61.6-1.4
Locomotion in novel chamber post-restriction1.01.22.30.11.5
Fecal boli incidents, locomotor time 11.21.32.00.8-1.4
Change in fecal boli incidents, locomotor task0.30.30.3-0.50.6
Time >=10cm from walls, locomotor time 10.30.30.5-0.7-0.4
Bouts of movement, locomotor time 11.31.51.81.3-1.1
Total resting periods, locomotor time 11.11.21.51.2-0.9
Rest time, locomotor task time 10.30.40.40.6-0.5
Distance moved, locomotor task time 10.10.10.2-0.40.2
Vertical activity count, locomotor time 10.91.01.9-1.40.3
Time >=10cm from walls, locomotor time 20.50.50.7-0.6-0.8
Bouts of movement, locomotor time 20.80.81.21.1-0.7
Total resting periods, locomotor time 20.40.50.80.9-0.4
Rest time, locomotor task time 20.70.81.0-1.00.8
Distance moved, locomotor task time 20.30.30.6-0.80.0
Vertical activity count, locomotor time 23.13.46.4-2.50.6
Light reinforcement 18.014.622.2-4.72.6
Light reinforcement 217.223.032.8-5.73.6
Bone: marrow area0.40.81.50.3-1.2
Bone: maximum diameter0.20.30.50.2-0.7
Bone: maximum force0.71.22.20.5-1.5
Bone: maximum moment0.50.81.50.4-1.2
Mean time between licks in bursts6.89.510.7-3.32.9
Mean num. licks in bursts0.60.81.51.2-0.2
Cd content in liver7.17.88.6-2.92.6
Co content in liver0.00.00.0-0.00.1
Cu content in liver1.31.62.60.7-1.6
Fe content in liver0.30.30.5-0.70.3
K content in liver0.20.20.3-0.6-0.4
Mg content in liver1.01.01.60.6-1.3
Mn content in liver0.20.30.50.7-0.2
Na content in liver9.910.414.72.5-3.8
Rb content in liver0.30.30.5-0.4-0.7
Se content in liver0.40.40.6-0.5-0.8
Sr content in liver1.91.82.41.5-1.1
Zn content in liver0.30.30.6-0.70.0
Bone: minimum diameter0.71.21.2-1.1-1.1
Time in familiar zone, hab. session 10.10.00.1-0.3-0.0
Time in novel zone, hab. session 10.00.00.1-0.00.3
Total zone transitions, hab. session 15.98.310.43.2-2.5
Total locomotion distance, hab. session 120.829.544.0-6.63.9
Locomotion velocity, hab. session 121.730.744.8-6.74.1
Time in familiar zone, hab. session 20.10.10.2-0.3-0.4
Time in novel zone, hab. session 20.40.40.60.40.8
Total zone transitions, hab. session 22.33.04.22.1-1.3
Total locomotion distance, hab. session 226.134.550.5-7.14.3
Locomotion velocity, hab. session 224.032.347.3-6.94.2
Novel to familiar place preference ratio1.21.21.3-1.11.1
Novelty place preference0.91.01.3-0.81.1
Time in novel zone, NPP test0.90.91.3-0.71.2
Total zone transitions, NPP test0.81.22.11.5-0.4
Total locomotion distance, NPP test32.444.361.0-7.85.3
Locomotion velocity, NPP test30.943.760.6-7.85.2
Intraocular pressure6.59.116.54.1-1.3
Delta distance traveled before/after self-admin0.10.10.2-0.40.2
Delta ambulatory time before/after self-admin0.20.20.2-0.50.4
Parametrial fat weight0.40.91.41.2-0.6
Pavlov. Cond. lever latency1.51.82.4-1.51.1
Pavlov. Cond. magazine entry latency0.30.30.6-0.20.8
Pavlov. Cond. change in total contacts0.10.20.3-0.1-0.6
Pavlov. Cond. index score0.40.50.80.9-0.3
Pavlov. Cond. latency score0.40.50.80.9-0.4
Pavlov. Cond. lever contacts0.91.11.31.2-0.9
Pavlov. Cond. magazine entry number0.20.20.2-0.5-0.4
Pavlov. Cond. intertrial magazine entries0.30.40.70.3-0.9
Pavlov. Cond. lever-magazine prob. diff.0.50.70.90.9-0.6
Pavlov. Cond. response bias0.10.10.10.4-0.0
Pavlov. Cond. lever latency1.52.03.7-0.5-1.9
Pavlov. Cond. magazine entry latency0.30.40.60.30.8
Pavlov. Cond. change in total contacts0.91.22.40.11.5
Pavlov. Cond. index score1.01.32.20.61.5
Pavlov. Cond. latency score0.91.11.80.61.4
Pavlov. Cond. lever contacts0.91.31.90.81.4
Pavlov. Cond. magazine entry number0.80.91.5-1.2-0.6
Pavlov. Cond. intertrial magazine entries0.50.71.20.4-1.1
Pavlov. Cond. lever-magazine prob. diff.0.91.22.10.51.5
Pavlov. Cond. response bias1.01.31.80.91.4
Time in closed arm before self-admin1.71.92.0-1.41.4
Time in closed arm after self-admin0.10.10.20.4-0.2
Time in open arm before self-admin0.40.50.60.7-0.6
Time in open arm after self-admin0.60.60.80.9-0.7
Bone: periosteal estimation0.61.22.40.2-1.5
Bone: periosteal perimeter0.10.20.3-0.1-0.6
Bone: post-yield work1.01.31.51.0-1.2
Progressive ratio test 1 active lever presses0.80.91.6-0.41.3
Progressive ratio test 1 breakpoint0.60.71.2-0.31.1
Progressive ratio test 1 inactive lever presses0.20.20.5-0.20.7
Progressive ratio test 2 active lever presses1.81.93.1-0.81.8
Progressive ratio test 2 breakpoint1.72.03.0-1.01.7
Progressive ratio test 2 inactive lever presses1.31.53.0-0.31.7
Incentive Sensitization - Responses1.21.21.3-1.11.1
Incentive Sensitization - Breakpoint1.41.51.6-1.11.3
Sum of active levers in priming session hrs 5-69.79.410.8-2.83.3
Progressive ratio1.01.22.1-0.51.4
Food seeking constrained by brief footshock2.93.54.3-2.11.7
Seeking ratio, punishment vs. effort0.50.61.2-1.1-0.1
Retroperitoneal fat weight1.44.66.5-2.61.6
Reaction time number correct1.72.44.62.1-0.5
Reaction time mean minus median0.10.20.2-0.40.4
Reaction time mean minus median AUC0.20.20.4-0.10.7
Reaction time num false alarms8.611.718.9-4.32.1
Reaction time num false alarms AUC6.59.014.7-3.81.8
Reaction time trials correct on left1.72.44.62.1-0.5
Reaction time trials on left1.72.44.52.1-0.5
Reaction time mean1.11.62.7-1.60.7
Reaction time mean AUC0.50.71.4-1.20.2
Median of all reaction times1.52.13.7-1.90.7
Reaction time omissions0.10.20.2-0.40.5
Reaction time false alarm rate8.311.519.4-4.41.9
Reaction time premature initiation rate0.10.10.20.3-0.4
Reaction time premature initiations0.81.22.11.4-0.5
Std. dev. reaction times0.00.00.1-0.3-0.1
Reaction time trials completed1.72.44.52.1-0.5
Reaction time trials AUC1.42.13.92.0-0.5
Run reversals in cocaine runway, females0.50.50.8-0.40.9
Run reversals in cocaine runway, males1.01.01.01.01.0
Latency to leave start box in cocaine runway3.23.57.0-2.6-0.1
Latency to leave start box in cocaine runway, F1.31.42.0-1.4-0.9
Latency to leave start box in cocaine runway, M4.74.57.5-2.71.2
Std. dev. time between licks in bursts2.32.74.5-2.11.0
Total sessions with >9 infusions5.46.06.6-2.32.6
Short access day 1 total inactive lever presses0.10.10.20.20.4
Short access day 10 total inactive lever presses2.42.64.80.7-2.2
Short access day 1 total infusions9.29.810.4-3.03.2
Short access day 10 total infusions2.02.23.0-1.21.7
Short access total infusions5.25.96.6-2.32.6
Short access day 1 locomotion1.41.52.0-1.41.0
Short access day 10 total locomotion0.91.11.11.0-1.0
Short access total locomotion0.10.10.1-0.40.4
One hour access (0.3 mA shock)3.64.37.0-1.22.7
Compulsive drug intake0.20.20.30.5-0.4
One hour access (shock baseline)2.22.54.2-0.92.0
Social response proportion0.10.10.20.40.1
Social responses0.10.10.20.30.4
Social time1.01.32.4-0.5-1.5
Soleus weight0.00.10.2-0.40.2
Bone: stiffness0.40.61.0-0.4-1.0
Tibialis anterior weight0.00.00.0-0.10.0
Time to tail flick, vehicle, before self-admin2.82.94.12.0-1.3
Time to tail flick, vehicle, after self-admin3.84.05.52.3-1.6
Time to tail flick, test, before self-admin3.23.13.91.5-2.0
Time to tail flick, test, after self-admin4.14.25.92.4-1.6
Delta time to tail flick, vehicle, before/after SA0.80.80.90.9-0.8
Delta time to tail flick, test, before/after SA0.00.00.10.00.3
Tibia length0.82.23.01.7-1.2
Ambulatory time before self-admin0.60.61.1-1.10.1
Ambulatory time after self-admin0.70.81.5-1.2-0.4
Bone: tissue strength0.30.30.6-0.2-0.8
Total heroin consumption0.40.50.7-0.80.6
Bone: trabecular number0.40.61.1-0.4-1.0
Bone: trabecular spacing1.11.42.51.6-0.6
Bone: trabecular thickness0.50.50.7-0.60.8
Bone: trabecular tissue density0.20.30.40.40.7
Water consumed over 24 hours2.12.53.21.3-1.8
Number of responses in last shaping day0.10.10.1-0.0-0.4