LOC102554269

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h²	h² SE	h² P	xQTL R²	BLUP R²	ENET R²	LASSO R²	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102554269	0.09	0.04	3.2e-03	0.02	0.02	0.01	0.02	9.5e-04	3.2e-03	1.1e-02	1.3e-03
2	Liver	intron excision ratio	chr7_30912032_30914315	0.33	0.08	1.3e-14	0.09	0.12	0.12	0.11	8.5e-10	9.4e-13	4.1e-13	3.0e-12
3	Liver	intron excision ratio	chr7_30912032_30912379	0.3	0.1	3.0e-10	0.07	0.07	0.09	0.1	3.2e-08	1.3e-08	1.0e-09	1.1e-10
4	Liver	intron excision ratio	chr7_30909047_30914315	0.56	0.1	0.0e+00	0.22	0.22	0.24	0.23	1.6e-24	1.7e-24	1.4e-26	3.8e-25
5	Liver	intron excision ratio	chr7_30909047_30909517	0.06	0.04	1.4e-03	0.03	0.02	0.01	0.01	2.7e-04	6.4e-03	6.8e-02	1.1e-02
6	Liver	intron excision ratio	chr7_30904196_30908945	0.33	0.09	1.6e-13	0.11	0.09	0.1	0.1	6.1e-12	1.4e-10	1.6e-11	1.2e-11

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi² ratio	Avg chi²	Max chi²	1	2	3	4	5	6
Bone: apparent density	0.3	0.6	1.1	-1.0	-0.7	1.1	0.8	-0.6	0.6
Area under the delay curve	0.1	0.1	0.2	-0.3	-0.3	0.2	0.1	-0.4	0.4
BMI with tail	1.6	5.7	13.0	-3.6	-2.9	2.8	1.6	-1.0	1.0
BMI without tail	0.4	2.4	8.8	-3.0	-1.1	1.8	-0.0	0.6	-0.6
Body weight	1.8	8.1	29.7	-5.4	-2.5	3.2	-0.1	1.0	-1.0
Weight adjusted by age	0.0	0.1	0.2	0.4	0.1	-0.2	0.1	-0.2	0.2
Bone surface	0.2	0.5	1.2	-1.1	-0.8	0.9	0.3	-0.3	0.3
Bone volume	0.3	0.7	1.6	-1.3	-0.9	1.1	0.5	-0.4	0.4
Breakpoint value in progressive ratio session	2.6	4.7	7.0	-0.8	-2.2	1.5	2.5	-2.6	2.6
Number of licking bursts	1.3	4.1	5.9	-2.4	-2.1	2.4	1.9	-1.6	1.6
Context. condit. distance diff. score	2.1	2.5	3.5	1.4	1.5	-1.6	-1.9	1.5	-1.5
Locomotion velocity, session 1	0.5	0.5	1.0	0.1	-0.5	0.1	0.9	-1.0	1.0
Locomotion distance, session 1	2.0	2.5	3.3	-1.3	-1.8	1.3	1.7	-1.7	1.7
Locomotion velocity, session 2	1.2	1.4	2.0	1.2	1.4	-1.1	-1.0	1.1	-1.1
Locomotion distance, session 2	0.9	1.3	2.0	-1.4	-1.4	1.2	1.0	-0.8	0.8
Locomotion velocity, session 3	1.6	1.8	3.8	1.9	0.6	-1.9	-1.1	1.0	-1.0
Locomotion distance, session 3	0.1	0.1	0.2	0.2	-0.3	-0.4	-0.3	0.2	-0.2
Stereotopy head waving bouts, day 3	0.8	1.0	1.5	-0.4	-0.8	0.8	1.2	-1.2	1.2
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.3	-0.3	0.0	0.4	-0.4	0.4
Locomotion velocity, session 7	0.4	0.5	0.8	0.8	0.9	-0.6	-0.6	0.6	-0.6
Locomotion distance, session 7	0.3	0.4	0.8	0.9	0.4	-0.7	-0.5	0.5	-0.5
Stereotopy head waving bouts, day 7	0.1	0.1	0.2	-0.2	-0.1	0.4	0.5	-0.2	0.2
Stereotopy head waving duration, day 7	0.3	0.4	0.7	-0.5	-0.7	0.7	0.9	-0.5	0.5
Locomotion velocity, session 8	1.4	1.7	2.0	1.3	1.4	-1.4	-1.4	1.2	-1.2
Locomotion distance, session 8	0.1	0.1	0.3	-0.3	-0.3	-0.1	-0.6	0.3	-0.3
Degree of sensitization distance	0.0	0.0	0.2	0.4	0.1	-0.1	0.0	0.1	-0.1
Degree of sensitization stereotypy	0.0	0.0	0.1	0.2	0.1	0.1	0.3	0.1	-0.1
Conditioned locomotion	0.2	0.3	1.0	0.2	1.0	-0.2	-0.3	0.5	-0.5
Cocaine response after cond. corrected	0.2	0.3	0.5	-0.0	0.6	-0.2	-0.7	0.7	-0.7
Cocaine response after cond. not corrected	0.0	0.0	0.1	-0.4	0.0	0.1	-0.3	0.2	-0.2
Cocaine response before conditioning	0.6	0.7	1.1	-0.5	-1.0	0.3	0.7	-1.1	1.1
Saline control response	1.2	1.7	2.9	0.7	0.8	-1.0	-1.5	1.7	-1.7
Bone: connectivity density	0.1	0.1	0.2	-0.2	-0.4	0.4	0.4	-0.4	0.4
Bone: cortical apparent density	0.0	0.1	0.3	-0.2	0.6	0.1	-0.1	-0.0	0.0
Bone: cortical area	1.1	1.9	3.6	-1.9	-1.7	1.5	0.9	-0.9	0.9
Bone: cortical porosity	1.8	1.9	2.7	0.9	1.5	-1.0	-1.5	1.6	-1.6
Bone: cortical porosity	0.6	0.7	1.0	0.3	0.9	-0.4	-0.9	1.0	-1.0
Bone: cortical thickness	0.1	0.1	0.2	-0.4	-0.1	0.0	-0.4	0.3	-0.3
Bone: cortical thickness	0.0	0.0	0.0	0.1	0.2	0.1	0.2	-0.1	0.1
Bone: cortical tissue density	0.1	0.1	0.6	-0.1	0.8	-0.1	-0.2	0.1	-0.1
Condit. Reinf. active minus inactive responses	0.2	0.3	1.0	1.0	0.2	-0.5	0.1	-0.4	0.4
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.3	0.5	-0.1	-0.2	0.3	-0.4	0.4
Condit. Reinf. active responses	0.2	0.3	0.6	0.8	0.1	-0.2	0.5	-0.7	0.7
Condit. Reinf. inactive responses	0.2	0.2	0.4	0.2	0.0	0.2	0.7	-0.6	0.6
Incentive salience index mean	0.3	0.4	0.8	0.1	-0.6	0.3	0.7	-0.9	0.9
Condit. Reinf. lever presses	0.8	1.1	1.3	-0.8	-1.1	1.1	1.1	-1.1	1.1
Condit. Reinf. active minus inactive responses	0.1	0.1	0.5	0.7	0.3	-0.5	-0.0	0.2	-0.2
Condit. Reinf. active-inactive response ratio	0.6	1.0	1.4	0.9	0.7	-1.2	-0.9	1.1	-1.1
Condit. Reinf. active responses	0.2	0.3	0.6	-0.0	-0.5	0.3	0.8	-0.7	0.7
Condit. Reinf. inactive responses	1.3	2.0	3.6	-0.5	-0.8	1.1	1.6	-1.9	1.9
Condit. Reinf. lever presses	0.1	0.1	0.3	-0.0	0.1	0.5	0.5	-0.1	0.1
Condit. Reinf. lever reinforcers received	0.5	0.8	1.3	-0.2	-0.9	0.6	1.1	-1.0	1.0
Conditioned reinforcement - actives	0.0	0.0	0.2	-0.5	-0.0	0.2	0.1	-0.0	0.0
Conditioned reinforcement - inactives	0.2	0.6	0.9	-1.0	-0.5	1.0	0.7	-0.6	0.6
Conditioned locomotion	0.1	0.1	0.1	-0.3	-0.2	-0.2	-0.2	0.4	-0.4
Patch foraging indifference point 0 sec	0.0	0.1	0.1	-0.2	0.3	0.3	0.1	-0.1	0.1
Patch foraging indifference point AUC	0.1	0.2	0.6	-0.8	-0.4	0.4	0.1	0.3	-0.3
Delay disc. indifference point, 0s delay	4.3	4.9	6.4	-1.9	-2.0	2.2	2.5	-2.3	2.3
Delay disc. indifference point, 16s delay	0.7	1.0	2.0	-1.4	-1.2	0.9	0.7	-0.8	0.8
Delay disc. indifference point, 2s delay	0.1	0.1	0.2	0.0	-0.4	-0.0	-0.1	-0.3	0.3
Delay disc. indifference point, 24s delay	0.2	0.4	1.0	-0.7	-1.0	0.2	0.2	-0.5	0.5
Delay disc. indifference point, 4s delay	0.3	0.3	0.5	0.7	0.7	-0.6	-0.7	0.4	-0.4
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	0.1	0.5	-0.4	-0.5	0.3	-0.3
Indifference point function ln k	0.1	0.2	0.5	-0.1	-0.2	0.3	0.5	-0.7	0.7
Indifference point function log k	0.1	0.2	0.5	-0.1	-0.2	0.3	0.5	-0.7	0.7
Patch foraging total patch changes 0 sec	0.0	0.1	0.2	-0.3	0.3	0.4	0.2	-0.1	0.1
Patch foraging total patch changes 12 sec	0.2	0.3	0.9	-1.0	-0.3	0.7	0.2	0.3	-0.3
Patch foraging total patch changes 18 sec	0.1	0.3	0.5	-0.5	0.7	0.2	-0.4	0.7	-0.7
Patch foraging total patch changes 24 sec	0.2	0.8	1.5	-0.3	0.7	-0.3	-1.0	1.2	-1.2
Patch foraging total patch changes 6 sec	0.2	0.4	1.1	-1.0	-0.4	0.9	0.6	-0.3	0.3
Patch foraging time to switch 0 sec	0.2	0.8	1.8	0.8	1.3	-0.7	-0.9	0.8	-0.8
Patch foraging water rate 0 sec	0.7	2.5	4.9	-2.2	-1.9	1.6	1.1	-1.1	1.1
Patch foraging water rate 12 sec	0.2	0.9	2.4	-1.6	-0.4	0.9	-0.3	1.0	-1.0
Patch foraging water rate 18 sec	0.2	0.5	1.9	-0.7	-1.4	0.6	0.6	-0.2	0.2
Patch foraging water rate 24 sec	1.3	1.9	5.0	-2.2	-1.5	1.5	0.8	-0.8	0.8
Patch foraging water rate 6 sec	2.9	4.3	12.3	-3.5	-1.9	2.5	1.3	-0.9	0.9
Seeking ratio, delayed vs. immediate footshock	0.9	1.3	1.8	-0.9	-0.8	1.4	1.1	-1.3	1.3
Distance traveled before self-admin	0.6	1.4	3.5	-0.8	-1.9	1.0	1.2	-1.0	1.0
Distance traveled after self-admin	1.6	2.7	3.9	-0.7	-2.0	1.1	1.9	-1.9	1.9
Extensor digitorum longus weight	0.1	0.2	0.5	-0.7	-0.4	0.5	-0.2	0.4	-0.4
Bone: elastic displacement	1.9	2.4	6.9	2.6	1.3	-2.0	-1.0	0.6	-0.6
Bone: elastic work	1.8	2.4	5.8	2.4	1.2	-2.0	-1.3	0.8	-0.8
Bone: endosteal estimation	1.2	3.0	4.3	-2.0	-1.7	2.1	1.7	-1.5	1.5
Bone: endosteal perimeter	1.7	4.1	7.4	-2.7	-2.1	2.3	1.5	-1.6	1.6
Epididymis fat weight	1.5	7.4	12.7	-3.6	-3.4	2.9	2.1	-1.9	1.9
Delta time in closed arm before/after self-admin	0.1	0.1	0.3	-0.2	-0.6	-0.2	-0.3	0.1	-0.1
Delta time in open arm before/after self-admin	0.2	0.2	1.0	0.4	1.0	0.2	0.4	0.0	-0.0
Diff in mean of infusions in LGA sessions	0.1	0.2	0.8	0.9	0.1	-0.7	-0.2	0.1	-0.1
Delay discount exponential model param	0.0	0.0	0.1	0.1	-0.0	0.2	0.3	0.0	-0.0
Extinction: sum of active levers before priming	0.1	0.2	0.4	-0.1	-0.6	0.0	0.3	-0.5	0.5
Active lever presses in extinction session 6	0.6	0.6	1.0	-0.3	-1.0	0.5	0.9	-0.8	0.8
Bone: final force	0.7	1.1	2.0	-1.4	-1.4	1.3	0.8	-0.6	0.6
Bone: final moment	0.8	1.4	2.6	-1.4	-1.6	1.3	0.9	-0.7	0.7
Food consumed during 24 hour testing period	0.1	0.2	0.6	-0.8	-0.3	0.5	0.2	0.1	-0.1
Glucose	0.7	1.1	1.7	-0.9	-1.3	1.2	1.1	-0.9	0.9
Heart weight	1.4	2.3	4.7	-1.9	-2.2	1.6	1.2	-1.0	1.0
Delay discount hyperbolic model param	0.0	0.1	0.2	-0.1	-0.2	0.3	0.4	-0.0	0.0
Intermittent access intake day 1-15 change	0.0	0.2	0.5	-0.7	-0.7	0.4	0.1	-0.1	0.1
Intermittent access intake escalation	0.1	0.4	0.9	-0.9	-0.9	0.7	0.4	-0.2	0.2
Intermittent access intake escalation 2	0.1	0.2	0.3	0.2	0.1	-0.4	-0.5	0.6	-0.6
Intermitt. access day 1 inactive lever presses	0.1	0.8	1.8	1.0	1.3	-0.8	-0.7	0.7	-0.7
Intermitt. access day 15 inactive lever presses	0.0	0.2	0.6	0.7	-0.1	-0.6	0.0	-0.2	0.2
Intermitt. access escalation Index	0.1	0.2	0.7	0.8	0.3	-0.7	-0.3	0.2	-0.2
Intermittent access day 1 total infusions	0.9	2.8	4.0	0.6	1.6	-1.3	-2.0	2.0	-2.0
Intermittent access day 15 total infusions	0.3	0.8	1.6	-0.1	0.5	-0.5	-1.1	1.3	-1.3
Intermittent access terminal intake (last 3 days)	0.6	1.1	1.8	0.1	0.7	-0.7	-1.3	1.3	-1.3
Intermittent access total infusions	1.3	1.5	2.4	0.3	1.0	-0.9	-1.5	1.5	-1.5
Intermittent access day 1 locomotion	3.0	5.5	7.4	1.2	2.7	-1.8	-2.5	2.7	-2.7
Intermittent access day 15 total locomotion	0.4	1.5	2.0	1.0	1.2	-1.1	-1.4	1.3	-1.3
Intermittent access total locomotion	3.0	3.5	5.2	0.9	1.9	-1.4	-2.1	2.3	-2.3
Intermittent access standard deviation	0.1	0.5	1.0	-0.5	0.1	-0.2	-0.9	1.0	-1.0
Left kidney weight	0.4	3.1	8.7	-2.9	-2.6	1.8	0.4	-0.1	0.1
Right kidney weight	0.7	4.8	11.2	-3.3	-3.0	2.5	1.1	-0.7	0.7
Cocaine induced anxiety	0.1	0.2	0.5	0.7	0.2	-0.2	0.4	-0.6	0.6
Post-drug Anxiety	0.2	0.3	0.8	0.9	0.1	-0.7	0.1	-0.3	0.3
Baseline Anxiety	0.2	0.3	0.5	0.0	-0.2	-0.5	-0.7	0.7	-0.7
Tail length	1.2	6.4	11.4	-1.6	1.7	-0.4	-3.2	3.4	-3.4
Length with tail	1.3	5.9	10.6	-3.3	0.0	0.9	-2.5	3.0	-3.0
Length without tail	0.5	2.4	7.8	-2.8	-1.3	1.4	-0.6	1.1	-1.1
Times rat made contact with spout	2.6	3.0	7.0	-2.6	-2.3	2.1	1.1	-0.6	0.6
Lifetime Intake	0.8	1.0	1.6	0.1	0.8	-0.6	-1.3	1.3	-1.3
Liver weight, left	0.7	1.3	2.2	-1.4	-0.1	0.5	-1.0	1.5	-1.5
Liver weight, right	0.5	0.8	2.7	-1.6	-0.4	1.0	-0.3	0.7	-0.7
Locomotor activity	2.0	3.2	7.6	-2.8	-2.2	2.0	1.1	-0.8	0.8
Locomotor testing distance	1.5	3.8	7.3	-2.7	-2.3	2.2	1.5	-1.3	1.3
Locomotor testing rearing	0.1	0.3	0.8	-0.9	-0.5	0.6	0.2	-0.4	0.4
Locomotion in novel chamber	0.0	0.1	0.2	0.2	-0.0	-0.3	-0.4	0.0	-0.0
Locomotion in novel chamber post-restriction	0.0	0.0	0.2	-0.1	-0.4	0.1	-0.2	0.0	-0.0
Fecal boli incidents, locomotor time 1	0.2	0.4	1.6	-0.3	1.2	0.2	-0.4	0.6	-0.6
Change in fecal boli incidents, locomotor task	1.0	1.0	2.9	1.6	0.4	-1.7	-0.7	0.1	-0.1
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.6	0.8	0.6	-0.5	-0.4	0.2	-0.2
Bouts of movement, locomotor time 1	2.6	3.3	4.2	-1.6	-1.7	1.8	2.0	-1.9	1.9
Total resting periods, locomotor time 1	1.8	2.0	2.8	-1.0	-1.3	1.2	1.7	-1.6	1.6
Rest time, locomotor task time 1	0.2	0.4	0.6	0.5	-0.4	-0.1	0.8	-0.8	0.8
Distance moved, locomotor task time 1	0.2	0.4	1.6	-1.3	-0.4	0.9	0.1	0.2	-0.2
Vertical activity count, locomotor time 1	0.2	1.1	4.1	-2.0	-0.9	1.3	0.3	-0.2	0.2
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.3	0.2	0.5	0.1	0.2	0.0	-0.0
Bouts of movement, locomotor time 2	0.0	0.0	0.1	0.3	-0.0	-0.3	-0.1	-0.2	0.2
Total resting periods, locomotor time 2	0.0	0.1	0.3	0.3	-0.3	-0.1	0.2	-0.5	0.5
Rest time, locomotor task time 2	0.5	0.9	1.6	-0.1	-1.0	0.2	1.1	-1.3	1.3
Distance moved, locomotor task time 2	0.3	0.4	1.3	-1.2	-0.1	0.9	0.2	0.4	-0.4
Vertical activity count, locomotor time 2	1.0	2.2	7.1	-2.7	-0.9	2.2	0.7	0.2	-0.2
Light reinforcement 1	0.6	2.5	5.8	-1.4	-2.4	1.2	1.6	-1.3	1.3
Light reinforcement 2	0.0	0.1	0.2	-0.3	-0.4	0.2	0.5	-0.1	0.1
Bone: marrow area	1.3	3.2	4.6	-2.0	-1.7	2.1	1.7	-1.5	1.5
Bone: maximum diameter	2.7	5.5	9.7	-3.1	-2.5	2.7	1.9	-1.8	1.8
Bone: maximum force	0.5	0.9	1.8	-0.9	-1.3	1.0	0.7	-0.7	0.7
Bone: maximum moment	0.7	1.3	2.6	-1.0	-1.6	1.1	0.9	-1.0	1.0
Mean time between licks in bursts	0.1	0.7	1.2	-0.6	-0.8	0.6	0.8	-1.1	1.1
Mean num. licks in bursts	0.3	0.8	1.1	0.9	0.5	-1.1	-1.0	1.0	-1.0
Cd content in liver	0.9	1.0	1.7	-0.9	-0.8	1.3	1.2	-0.9	0.9
Co content in liver	1.0	1.2	1.8	-1.1	-0.7	1.0	1.0	-1.3	1.3
Cu content in liver	0.3	0.4	0.6	-0.6	0.6	0.4	-0.2	0.8	-0.8
Fe content in liver	0.5	0.7	0.9	0.8	0.7	-0.7	-0.9	0.9	-0.9
K content in liver	2.2	2.1	5.2	0.4	2.3	-0.5	-1.2	1.7	-1.7
Mg content in liver	0.2	0.2	1.1	0.2	1.0	-0.1	-0.2	0.3	-0.3
Mn content in liver	0.1	0.1	0.4	-0.6	0.4	0.4	0.1	0.1	-0.1
Na content in liver	0.3	0.3	1.2	0.1	1.1	-0.0	-0.3	0.6	-0.6
Rb content in liver	3.9	4.6	8.7	1.6	3.0	-1.7	-2.0	2.1	-2.1
Se content in liver	0.2	0.2	0.8	0.5	0.9	-0.2	-0.2	0.4	-0.4
Sr content in liver	2.4	2.1	4.1	-0.9	-2.0	1.1	1.5	-1.4	1.4
Zn content in liver	0.4	0.5	1.0	-0.2	0.4	-0.1	-0.7	1.0	-1.0
Bone: minimum diameter	2.4	4.6	9.1	-3.0	-2.7	2.4	1.5	-1.3	1.3
Time in familiar zone, hab. session 1	0.1	0.1	0.1	0.3	-0.1	-0.1	0.3	-0.3	0.3
Time in novel zone, hab. session 1	1.2	1.4	1.6	0.9	1.3	-1.1	-1.3	1.2	-1.2
Total zone transitions, hab. session 1	3.4	4.7	6.4	-2.5	-2.5	2.1	1.9	-1.9	1.9
Total locomotion distance, hab. session 1	3.8	5.4	8.8	-2.4	-3.0	2.1	2.2	-2.2	2.2
Locomotion velocity, hab. session 1	6.4	9.1	14.2	-3.0	-3.8	2.7	2.8	-2.9	2.9
Time in familiar zone, hab. session 2	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4	0.5	-0.5
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.2	-0.1	-0.1	0.3	-0.4	0.4
Total zone transitions, hab. session 2	2.5	3.2	4.3	-1.6	-2.1	1.4	1.6	-1.9	1.9
Total locomotion distance, hab. session 2	4.8	6.3	8.6	-2.2	-2.9	2.1	2.5	-2.6	2.6
Locomotion velocity, hab. session 2	5.3	7.1	9.2	-2.3	-3.0	2.3	2.6	-2.8	2.8
Novel to familiar place preference ratio	0.3	0.3	0.9	0.8	0.9	-0.6	-0.4	0.3	-0.3
Novelty place preference	0.5	0.6	1.3	1.1	1.1	-0.8	-0.5	0.4	-0.4
Time in novel zone, NPP test	0.5	0.6	1.2	1.0	1.1	-0.8	-0.5	0.5	-0.5
Total zone transitions, NPP test	1.3	2.0	2.9	-1.6	-1.7	1.3	1.1	-1.3	1.3
Total locomotion distance, NPP test	3.2	4.5	6.9	-2.0	-2.6	1.9	2.0	-2.0	2.0
Locomotion velocity, NPP test	2.7	3.9	5.7	-1.7	-2.4	1.7	1.9	-2.0	2.0
Intraocular pressure	0.4	0.6	1.1	-0.1	-1.0	0.3	0.8	-0.9	0.9
Delta distance traveled before/after self-admin	0.3	0.4	0.6	-0.4	-0.3	0.5	0.8	-0.8	0.8
Delta ambulatory time before/after self-admin	0.1	0.2	0.3	0.2	0.4	0.1	0.5	-0.6	0.6
Parametrial fat weight	1.1	2.7	3.2	-1.7	-1.4	1.8	1.8	-1.6	1.6
Pavlov. Cond. lever latency	0.2	0.3	0.5	-0.1	0.6	-0.5	-0.7	0.6	-0.6
Pavlov. Cond. magazine entry latency	1.1	1.4	2.1	-0.7	-0.9	1.0	1.3	-1.4	1.4
Pavlov. Cond. change in total contacts	1.1	1.1	1.5	-1.0	-1.0	1.2	1.2	-1.0	1.0
Pavlov. Cond. index score	1.6	2.0	2.6	-0.8	-1.3	1.3	1.6	-1.6	1.6
Pavlov. Cond. latency score	1.6	2.0	2.7	-0.8	-1.5	1.3	1.6	-1.6	1.6
Pavlov. Cond. lever contacts	0.5	0.6	0.9	-0.2	-0.9	0.8	0.9	-0.8	0.8
Pavlov. Cond. magazine entry number	1.1	1.4	1.7	0.9	1.0	-1.1	-1.3	1.3	-1.3
Pavlov. Cond. intertrial magazine entries	0.5	0.6	0.8	0.5	0.9	-0.7	-0.9	0.8	-0.8
Pavlov. Cond. lever-magazine prob. diff.	1.9	2.4	3.1	-1.0	-1.4	1.5	1.8	-1.7	1.7
Pavlov. Cond. response bias	0.7	0.9	1.4	-0.5	-0.7	1.0	1.2	-1.1	1.1
Pavlov. Cond. lever latency	0.2	0.3	0.5	0.3	0.5	-0.6	-0.7	0.4	-0.4
Pavlov. Cond. magazine entry latency	0.3	0.5	0.8	0.5	0.4	-0.9	-0.8	0.7	-0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.5	-0.7	-0.3	0.5	0.0	-0.1	0.1
Pavlov. Cond. index score	0.0	0.1	0.1	-0.0	0.2	-0.1	-0.3	0.4	-0.4
Pavlov. Cond. latency score	0.0	0.0	0.1	-0.0	0.3	-0.1	-0.2	0.2	-0.2
Pavlov. Cond. lever contacts	0.4	0.6	0.8	-0.7	-0.8	0.9	0.9	-0.6	0.6
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	0.7	0.5	-0.4	-0.2	0.2	-0.2
Pavlov. Cond. intertrial magazine entries	0.0	0.0	0.1	0.3	-0.0	-0.1	0.2	-0.2	0.2
Pavlov. Cond. lever-magazine prob. diff.	0.1	0.1	0.2	-0.0	0.2	-0.2	-0.5	0.5	-0.5
Pavlov. Cond. response bias	0.2	0.3	0.5	-0.6	-0.7	0.6	0.6	-0.3	0.3
Time in closed arm before self-admin	0.1	0.1	0.2	0.4	-0.5	-0.4	-0.2	0.1	-0.1
Time in closed arm after self-admin	0.2	0.2	1.1	-0.0	-1.0	0.1	0.3	-0.4	0.4
Time in open arm before self-admin	0.4	0.5	0.7	-0.6	-0.5	0.7	0.8	-0.7	0.7
Time in open arm after self-admin	0.2	0.2	1.1	0.2	1.0	0.2	0.4	-0.2	0.2
Bone: periosteal estimation	1.3	3.0	4.7	-2.2	-1.9	2.0	1.4	-1.4	1.4
Bone: periosteal perimeter	1.0	2.1	3.3	-1.8	-1.6	1.5	1.0	-1.2	1.2
Bone: post-yield work	0.1	0.1	0.4	-0.0	-0.6	0.1	-0.2	0.3	-0.3
Progressive ratio test 1 active lever presses	1.2	2.1	4.0	-0.8	0.9	-0.4	-1.7	2.0	-2.0
Progressive ratio test 1 breakpoint	1.2	2.1	4.0	-0.8	0.9	-0.4	-1.8	2.0	-2.0
Progressive ratio test 1 inactive lever presses	0.1	0.2	0.3	-0.2	0.6	0.0	-0.4	0.5	-0.5
Progressive ratio test 2 active lever presses	1.0	1.4	2.3	0.5	0.8	-0.9	-1.4	1.5	-1.5
Progressive ratio test 2 breakpoint	1.0	1.3	2.1	0.4	0.8	-0.9	-1.4	1.5	-1.5
Progressive ratio test 2 inactive lever presses	0.2	0.8	1.0	0.9	0.5	-0.8	-0.9	1.0	-1.0
Incentive Sensitization - Responses	0.2	0.5	0.9	0.6	0.5	-0.6	-0.9	0.8	-0.8
Incentive Sensitization - Breakpoint	0.2	0.5	0.8	0.7	0.5	-0.6	-0.9	0.8	-0.8
Sum of active levers in priming session hrs 5-6	0.8	0.8	1.6	-1.3	-1.1	1.0	0.8	-0.3	0.3
Progressive ratio	0.6	1.6	5.1	2.3	0.9	-1.8	-0.8	-0.1	0.1
Food seeking constrained by brief footshock	4.2	5.2	7.8	1.3	1.9	-2.0	-2.8	2.6	-2.6
Seeking ratio, punishment vs. effort	0.3	0.7	1.8	-1.3	-0.2	0.7	-0.2	1.0	-1.0
Retroperitoneal fat weight	1.3	5.9	12.6	-3.6	-2.7	2.8	1.7	-1.6	1.6
Reaction time number correct	0.1	0.3	0.9	-0.3	-1.0	0.3	0.5	-0.3	0.3
Reaction time mean minus median	0.0	0.2	0.6	0.8	-0.4	-0.1	0.4	-0.5	0.5
Reaction time mean minus median AUC	0.0	0.2	0.8	0.9	-0.2	-0.4	0.2	-0.3	0.3
Reaction time num false alarms	0.2	0.3	0.8	0.7	0.9	-0.6	-0.3	0.4	-0.4
Reaction time num false alarms AUC	0.1	0.2	0.7	0.8	0.7	-0.5	-0.1	0.1	-0.1
Reaction time trials correct on left	0.1	0.3	0.9	-0.3	-1.0	0.3	0.5	-0.3	0.3
Reaction time trials on left	0.1	0.3	0.9	-0.3	-1.0	0.3	0.5	-0.3	0.3
Reaction time mean	0.4	0.8	1.4	-0.7	-1.2	0.8	0.8	-0.9	0.9
Reaction time mean AUC	0.1	0.3	0.7	-0.5	-0.9	0.6	0.4	-0.5	0.5
Median of all reaction times	0.5	0.8	1.3	-1.0	-1.1	1.0	0.7	-0.8	0.8
Reaction time omissions	0.5	0.7	1.3	1.1	-0.3	-0.2	0.8	-1.1	1.1
Reaction time false alarm rate	0.3	0.5	1.4	0.9	1.2	-0.7	-0.4	0.3	-0.3
Reaction time premature initiation rate	8.6	13.3	15.2	-3.3	-3.9	3.7	3.8	-3.5	3.5
Reaction time premature initiations	3.6	11.0	15.1	-3.0	-3.9	3.4	3.5	-3.0	3.0
Std. dev. reaction times	0.1	0.5	0.9	0.5	-0.7	0.1	0.7	-0.9	0.9
Reaction time trials completed	0.1	0.3	0.9	-0.3	-1.0	0.3	0.5	-0.3	0.3
Reaction time trials AUC	0.1	0.3	1.0	-0.4	-1.0	0.5	0.5	-0.3	0.3
Run reversals in cocaine runway, females	0.5	0.6	1.3	-1.0	-1.1	0.6	0.6	-0.6	0.6
Run reversals in cocaine runway, males	0.4	0.5	1.0	0.4	0.2	-0.5	-0.5	1.0	-1.0
Latency to leave start box in cocaine runway	0.1	0.1	0.3	0.0	-0.6	0.1	0.1	0.2	-0.2
Latency to leave start box in cocaine runway, F	0.2	0.3	0.6	0.3	-0.6	0.3	0.8	-0.5	0.5
Latency to leave start box in cocaine runway, M	0.7	0.7	1.6	-0.0	0.1	-0.4	-1.0	1.2	-1.2
Std. dev. time between licks in bursts	0.2	0.5	1.2	0.1	-0.2	0.1	0.6	-1.1	1.1
Total sessions with >9 infusions	0.4	0.5	1.0	-0.7	0.3	0.3	-0.7	1.0	-1.0
Short access day 1 total inactive lever presses	0.1	0.1	0.2	0.4	0.1	-0.1	-0.4	0.4	-0.4
Short access day 10 total inactive lever presses	0.2	1.4	4.4	2.1	1.0	-1.7	-0.6	0.2	-0.2
Short access day 1 total infusions	0.1	0.2	0.4	0.6	0.4	-0.4	-0.6	0.4	-0.4
Short access day 10 total infusions	0.9	1.5	2.4	-0.1	1.2	-0.5	-1.5	1.6	-1.6
Short access total infusions	0.3	0.5	0.8	0.0	0.8	-0.3	-0.9	0.8	-0.8
Short access day 1 locomotion	0.2	0.4	0.9	-0.4	0.1	0.2	-0.4	0.9	-0.9
Short access day 10 total locomotion	0.7	2.8	5.5	1.0	2.4	-1.3	-1.6	1.7	-1.7
Short access total locomotion	1.1	1.7	3.0	-0.0	1.5	-0.5	-1.4	1.7	-1.7
One hour access (0.3 mA shock)	0.6	0.7	1.3	-0.6	0.0	-0.3	-1.1	1.1	-1.1
Compulsive drug intake	0.2	0.2	0.6	0.4	0.8	-0.5	-0.6	0.2	-0.2
One hour access (shock baseline)	0.1	0.4	0.7	-0.3	-0.2	-0.2	-0.7	0.9	-0.9
Social response proportion	0.5	0.7	1.7	-0.9	-1.3	1.0	0.5	-0.3	0.3
Social responses	2.1	2.8	5.5	-1.5	-2.3	1.6	1.5	-1.4	1.4
Social time	0.4	0.7	2.8	-0.7	-1.7	0.6	0.2	0.3	-0.3
Soleus weight	0.9	2.6	4.2	-1.8	-2.1	1.6	1.5	-1.3	1.3
Bone: stiffness	2.5	4.6	9.4	-3.1	-2.1	2.8	1.7	-1.2	1.2
Tibialis anterior weight	0.2	0.6	0.8	-0.8	-0.9	0.8	0.7	-0.6	0.6
Time to tail flick, vehicle, before self-admin	1.9	2.4	5.5	-2.3	-1.5	1.9	1.1	-1.0	1.0
Time to tail flick, vehicle, after self-admin	0.3	0.7	1.4	1.2	1.1	-0.6	-0.3	0.6	-0.6
Time to tail flick, test, before self-admin	0.0	0.0	0.1	0.1	0.3	-0.1	-0.2	0.1	-0.1
Time to tail flick, test, after self-admin	0.0	0.0	0.1	-0.2	-0.3	0.3	0.2	-0.1	0.1
Delta time to tail flick, vehicle, before/after SA	3.0	3.2	6.4	2.5	2.0	-1.9	-1.2	1.3	-1.3
Delta time to tail flick, test, before/after SA	0.0	0.0	0.0	0.2	-0.2	0.1	0.2	0.1	-0.1
Tibia length	1.0	2.7	10.1	-3.2	-1.8	1.6	-0.3	0.4	-0.4
Ambulatory time before self-admin	0.3	0.9	2.7	-0.8	-1.7	0.9	0.9	-0.6	0.6
Ambulatory time after self-admin	2.1	3.4	4.3	-1.0	-2.0	1.4	2.1	-2.1	2.1
Bone: tissue strength	0.2	0.2	0.6	-0.8	-0.6	0.5	0.2	0.1	-0.1
Total heroin consumption	5.4	6.4	8.8	-1.3	-2.4	2.3	2.9	-3.0	3.0
Bone: trabecular number	0.2	0.3	0.5	-0.5	-0.6	0.7	0.6	-0.5	0.5
Bone: trabecular spacing	0.2	0.2	0.8	0.9	0.1	-0.7	-0.1	-0.3	0.3
Bone: trabecular thickness	0.1	0.1	0.4	-0.6	-0.2	0.5	0.1	0.3	-0.3
Bone: trabecular tissue density	0.2	0.3	0.6	-0.7	0.4	0.8	0.5	-0.4	0.4
Water consumed over 24 hours	0.4	0.9	2.1	-1.4	-0.1	0.9	-0.3	1.1	-1.1
Number of responses in last shaping day	1.2	1.5	2.8	1.3	0.7	-1.7	-1.4	1.0	-1.0