Hub : Genes

LOC102553702

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102553702	0.78	0.05	0.0e+00	0.62	0.62	0.64	0.63	5.2e-87	3.6e-88	8.2e-92	9.3e-90
2	Liver	isoform ratio	XR_005499663.2	0.06	0.04	1.8e-08	0.06	0.06	0.06	0.06	5.0e-07	1.5e-07	2.7e-07	4.8e-07
3	Liver	intron excision ratio	chr1_243922142_243923645	0.07	0.05	9.5e-06	0.03	0.04	0.03	0.04	6.7e-04	6.0e-05	1.4e-04	7.0e-05
4	Liver	intron excision ratio	chr1_243922570_243922758	0.02	0.01	4.9e-03	0.01	0.01	0.01	0.01	1.3e-02	1.1e-02	7.3e-03	3.5e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	7.6	13.9	19.2	4.4	-4.1	-3.7	-2.5
Area under the delay curve	0.2	0.3	0.9	-0.5	0.4	0.2	1.0
BMI with tail	0.1	0.4	0.9	1.0	-0.6	-0.4	-0.2
BMI without tail	0.0	0.1	0.3	-0.0	-0.0	0.2	0.6
Body weight	0.9	3.8	5.1	2.3	-2.2	-1.7	-1.5
Weight adjusted by age	0.1	0.2	0.5	0.5	-0.4	-0.7	0.0
Bone surface	3.4	6.8	9.8	3.1	-3.0	-2.5	-1.4
Bone volume	5.1	10.1	13.6	3.6	-3.7	-3.2	-1.9
Breakpoint value in progressive ratio session	0.3	0.5	0.7	0.7	-0.5	-0.7	-0.8
Number of licking bursts	0.8	2.4	3.0	-1.7	1.7	1.4	1.3
Context. condit. distance diff. score	2.1	2.5	4.3	1.3	-1.9	-2.1	-0.8
Locomotion velocity, session 1	3.1	3.5	4.2	-1.6	1.9	2.0	1.9
Locomotion distance, session 1	0.1	0.2	0.3	-0.3	0.5	0.5	0.0
Locomotion velocity, session 2	1.1	1.3	1.5	-1.1	1.1	1.2	1.2
Locomotion distance, session 2	0.3	0.4	0.6	-0.8	0.7	0.6	0.1
Locomotion velocity, session 3	0.1	0.1	0.2	0.1	-0.5	-0.4	-0.0
Locomotion distance, session 3	0.4	0.5	0.8	0.2	-0.9	-0.9	-0.5
Stereotopy head waving bouts, day 3	0.1	0.2	0.5	0.0	0.2	0.4	0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	0.2	0.2	0.2	0.4
Locomotion velocity, session 7	1.2	1.3	2.1	0.5	-1.0	-1.4	-1.5
Locomotion distance, session 7	1.2	1.5	2.6	0.7	-1.1	-1.4	-1.6
Stereotopy head waving bouts, day 7	0.5	0.6	1.5	-0.5	0.5	0.7	1.2
Stereotopy head waving duration, day 7	0.3	0.4	1.1	-0.1	0.3	0.7	1.0
Locomotion velocity, session 8	0.2	0.3	0.3	0.5	-0.5	-0.6	-0.6
Locomotion distance, session 8	0.5	0.8	1.6	0.4	-1.0	-1.3	-0.6
Degree of sensitization distance	0.1	0.1	0.5	-0.0	0.2	-0.2	-0.7
Degree of sensitization stereotypy	0.2	0.2	0.7	-0.0	0.1	0.4	0.8
Conditioned locomotion	0.7	0.8	1.3	0.8	-1.0	-1.1	-0.3
Cocaine response after cond. corrected	0.1	0.2	0.6	0.0	-0.2	-0.1	0.8
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.1	-0.4	-0.4	0.1
Cocaine response before conditioning	0.2	0.3	0.6	-0.4	0.4	0.3	-0.8
Saline control response	0.2	0.3	0.9	-0.1	-0.5	-0.9	-0.2
Bone: connectivity density	3.9	6.3	9.9	3.2	-2.6	-2.3	-1.7
Bone: cortical apparent density	1.3	2.0	3.0	-1.3	1.4	1.2	1.7
Bone: cortical area	3.0	4.9	7.1	2.0	-2.7	-2.3	-1.8
Bone: cortical porosity	0.0	0.0	0.1	-0.1	0.3	0.1	-0.3
Bone: cortical porosity	0.0	0.0	0.2	0.1	-0.0	-0.1	-0.4
Bone: cortical thickness	0.3	0.5	0.9	0.3	-1.0	-0.8	-0.6
Bone: cortical thickness	0.1	0.1	0.3	-0.5	0.3	0.1	0.5
Bone: cortical tissue density	1.4	2.1	3.2	-1.3	1.4	1.3	1.8
Condit. Reinf. active minus inactive responses	1.2	1.3	2.0	-1.4	1.0	0.9	1.3
Condit. Reinf. active-inactive response ratio	1.7	1.9	2.1	-1.4	1.3	1.5	1.3
Condit. Reinf. active responses	0.2	0.2	0.5	-0.5	-0.2	-0.3	0.7
Condit. Reinf. inactive responses	1.2	1.5	2.7	0.9	-1.5	-1.6	-0.4
Incentive salience index mean	1.0	1.3	2.8	-1.7	1.0	0.8	1.0
Condit. Reinf. lever presses	1.1	1.6	3.2	-1.8	1.3	1.1	0.7
Condit. Reinf. active minus inactive responses	0.3	0.4	1.1	0.1	-0.8	-1.0	0.0
Condit. Reinf. active-inactive response ratio	0.1	0.2	0.3	-0.3	-0.3	-0.5	0.6
Condit. Reinf. active responses	1.2	1.7	2.9	1.0	-1.7	-1.7	-0.4
Condit. Reinf. inactive responses	0.7	1.1	1.8	1.0	-1.4	-1.1	-0.5
Condit. Reinf. lever presses	0.1	0.1	0.2	-0.0	-0.4	-0.4	0.5
Condit. Reinf. lever reinforcers received	0.7	1.0	1.8	0.7	-1.3	-1.4	-0.2
Conditioned reinforcement - actives	0.5	2.0	4.5	2.1	-1.1	-0.8	-1.2
Conditioned reinforcement - inactives	0.6	1.5	2.9	1.7	-1.1	-1.0	-1.0
Conditioned locomotion	1.0	1.5	3.5	1.9	-0.9	-0.5	-1.1
Patch foraging indifference point 0 sec	0.1	0.3	0.9	0.2	0.5	1.0	-0.2
Patch foraging indifference point AUC	0.5	1.2	1.4	-1.1	1.2	1.2	0.8
Delay disc. indifference point, 0s delay	0.3	0.4	1.2	0.1	-0.6	-1.1	-0.1
Delay disc. indifference point, 16s delay	0.1	0.1	0.2	0.4	-0.4	-0.3	0.3
Delay disc. indifference point, 2s delay	0.1	0.1	0.4	-0.0	0.1	-0.1	0.6
Delay disc. indifference point, 24s delay	1.2	1.9	3.1	-1.6	1.1	1.0	1.7
Delay disc. indifference point, 4s delay	0.1	0.1	0.2	-0.0	-0.1	-0.3	0.4
Delay disc. indifference point, 8s delay	1.3	2.2	2.5	-1.4	1.5	1.4	1.6
Indifference point function ln k	0.6	1.7	2.3	1.3	-1.5	-1.4	-0.8
Indifference point function log k	0.6	1.7	2.3	1.3	-1.5	-1.4	-0.8
Patch foraging total patch changes 0 sec	0.1	0.3	0.8	0.3	0.4	0.9	-0.2
Patch foraging total patch changes 12 sec	1.3	1.8	2.8	-1.1	1.6	1.7	0.7
Patch foraging total patch changes 18 sec	0.2	0.4	0.6	-0.3	0.7	0.8	0.7
Patch foraging total patch changes 24 sec	0.1	0.3	0.5	-0.5	0.6	0.7	0.1
Patch foraging total patch changes 6 sec	1.2	2.0	4.0	-1.1	1.6	2.0	0.4
Patch foraging time to switch 0 sec	0.2	0.9	1.2	-1.1	1.1	0.9	0.8
Patch foraging water rate 0 sec	0.2	0.6	1.1	0.8	-0.7	-0.6	-1.0
Patch foraging water rate 12 sec	0.2	0.7	1.5	0.9	-0.7	-0.3	-1.2
Patch foraging water rate 18 sec	0.7	1.5	3.1	1.1	-1.0	-0.8	-1.8
Patch foraging water rate 24 sec	1.6	2.3	3.6	1.2	-1.5	-1.4	-1.9
Patch foraging water rate 6 sec	0.0	0.0	0.1	0.3	-0.3	-0.0	0.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.1	0.2	-0.4	0.1	0.0	0.3
Distance traveled before self-admin	0.1	0.3	0.8	-0.9	0.4	0.2	0.4
Distance traveled after self-admin	0.2	0.3	0.5	0.7	-0.5	-0.7	0.2
Extensor digitorum longus weight	0.4	1.7	3.0	0.3	-1.4	-1.7	-1.3
Bone: elastic displacement	2.0	2.5	3.3	-1.3	1.8	1.7	1.5
Bone: elastic work	0.7	0.9	1.4	-0.6	1.2	1.0	1.0
Bone: endosteal estimation	4.1	10.0	13.2	3.6	-3.6	-3.1	-2.1
Bone: endosteal perimeter	4.9	11.9	15.2	3.9	-3.6	-3.2	-3.0
Epididymis fat weight	0.7	3.4	4.5	2.1	-2.1	-2.1	-0.7
Delta time in closed arm before/after self-admin	1.1	1.0	1.7	-0.9	1.2	1.3	0.4
Delta time in open arm before/after self-admin	0.2	0.2	0.5	-0.2	-0.3	-0.7	0.6
Diff in mean of infusions in LGA sessions	0.3	0.5	0.6	0.8	-0.7	-0.7	-0.8
Delay discount exponential model param	0.3	0.4	0.9	0.5	-0.5	-0.3	-1.0
Extinction: sum of active levers before priming	0.1	0.1	0.4	0.1	-0.3	-0.2	-0.7
Active lever presses in extinction session 6	1.7	1.7	3.3	1.1	-1.3	-1.8	-0.8
Bone: final force	1.2	2.0	2.7	1.4	-1.6	-1.3	-1.2
Bone: final moment	1.1	1.8	2.4	1.5	-1.6	-1.1	-1.2
Food consumed during 24 hour testing period	0.1	0.2	0.3	-0.4	0.3	0.6	0.2
Glucose	0.0	0.0	0.1	-0.3	0.0	0.1	0.3
Heart weight	0.3	0.5	1.3	-0.1	0.4	1.2	0.6
Delay discount hyperbolic model param	0.3	0.4	0.9	0.5	-0.5	-0.4	-1.0
Intermittent access intake day 1-15 change	0.5	2.6	5.3	2.3	-1.3	-0.7	-1.8
Intermittent access intake escalation	0.5	2.7	5.0	2.2	-1.4	-0.9	-1.7
Intermittent access intake escalation 2	0.5	0.9	1.9	1.4	-0.6	-0.4	-1.1
Intermitt. access day 1 inactive lever presses	0.0	0.6	1.1	-1.0	0.5	0.3	1.0
Intermitt. access day 15 inactive lever presses	0.4	1.9	3.7	1.9	-1.4	-1.1	-0.9
Intermitt. access escalation Index	0.2	0.6	1.2	-1.1	0.9	0.7	0.4
Intermittent access day 1 total infusions	0.8	2.5	4.4	2.1	-1.5	-1.4	-1.3
Intermittent access day 15 total infusions	2.5	6.2	11.0	3.3	-2.4	-1.8	-2.2
Intermittent access terminal intake (last 3 days)	2.5	4.3	8.5	2.9	-1.9	-1.4	-1.8
Intermittent access total infusions	3.3	3.9	6.9	2.6	-1.8	-1.5	-1.7
Intermittent access day 1 locomotion	1.1	2.0	3.0	1.7	-1.4	-1.2	-1.2
Intermittent access day 15 total locomotion	1.0	3.9	7.8	2.8	-1.9	-1.4	-1.5
Intermittent access total locomotion	3.3	3.9	7.0	2.6	-1.8	-1.7	-1.6
Intermittent access standard deviation	0.3	1.7	2.9	1.7	-1.4	-0.9	-1.2
Left kidney weight	0.2	1.5	2.1	1.4	-1.4	-0.9	-1.1
Right kidney weight	0.0	0.3	0.6	0.7	-0.5	0.0	-0.8
Cocaine induced anxiety	0.3	0.7	1.1	0.5	-0.7	-1.0	-1.0
Post-drug Anxiety	0.4	0.5	0.6	0.8	-0.8	-0.7	-0.4
Baseline Anxiety	0.1	0.2	0.4	0.6	-0.6	-0.2	0.4
Tail length	0.2	0.9	1.7	0.8	-1.3	-1.2	-0.2
Length with tail	1.1	4.9	6.7	2.3	-2.6	-2.1	-1.8
Length without tail	1.8	9.5	10.8	3.1	-3.3	-3.0	-2.9
Times rat made contact with spout	0.1	0.2	0.5	-0.0	-0.3	-0.7	-0.0
Lifetime Intake	3.2	3.9	7.5	2.7	-1.8	-1.5	-1.7
Liver weight, left	0.5	0.9	1.6	0.9	-1.3	-1.0	-0.4
Liver weight, right	1.6	2.7	4.1	2.0	-1.8	-1.5	-1.2
Locomotor activity	0.5	0.8	1.2	-0.7	0.8	0.8	1.1
Locomotor testing distance	0.6	1.5	2.1	-0.9	1.4	1.4	1.0
Locomotor testing rearing	0.0	0.1	0.3	0.1	-0.3	-0.4	-0.5
Locomotion in novel chamber	1.2	1.6	3.1	1.1	-1.5	-1.8	-0.1
Locomotion in novel chamber post-restriction	0.8	2.5	4.0	1.2	-2.0	-2.0	-1.0
Fecal boli incidents, locomotor time 1	0.1	0.3	0.9	0.2	-0.1	-0.4	-1.0
Change in fecal boli incidents, locomotor task	0.3	0.3	0.5	-0.6	0.5	0.7	-0.1
Time >=10cm from walls, locomotor time 1	2.2	2.8	3.8	0.8	-2.0	-1.9	-1.7
Bouts of movement, locomotor time 1	0.5	0.6	1.3	1.2	-0.5	-0.5	-0.7
Total resting periods, locomotor time 1	0.8	0.9	1.7	1.3	-0.6	-0.7	-1.0
Rest time, locomotor task time 1	0.1	0.2	0.3	0.5	0.5	0.3	-0.4
Distance moved, locomotor task time 1	0.3	0.7	1.7	-1.3	0.0	0.1	1.1
Vertical activity count, locomotor time 1	0.0	0.0	0.1	-0.2	-0.3	-0.1	0.1
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.3	-0.3	-0.3	-0.5	-0.5
Bouts of movement, locomotor time 2	0.3	1.1	2.4	-0.9	1.5	1.2	0.0
Total resting periods, locomotor time 2	0.3	1.1	2.4	-0.8	1.5	1.2	-0.1
Rest time, locomotor task time 2	0.1	0.2	0.5	0.5	0.1	-0.1	-0.7
Distance moved, locomotor task time 2	0.4	0.5	1.1	-0.9	-0.2	-0.2	1.0
Vertical activity count, locomotor time 2	0.2	0.6	0.8	-0.8	0.8	0.9	0.6
Light reinforcement 1	0.1	0.6	1.4	1.2	-0.7	-0.7	-0.0
Light reinforcement 2	1.1	2.4	3.3	-1.2	1.8	1.6	1.6
Bone: marrow area	4.3	10.7	14.3	3.8	-3.7	-3.2	-2.1
Bone: maximum diameter	8.5	17.1	22.0	4.4	-4.7	-4.3	-3.0
Bone: maximum force	2.1	4.1	5.6	2.2	-2.4	-1.9	-1.5
Bone: maximum moment	2.0	3.7	5.2	2.3	-2.2	-1.6	-1.5
Mean time between licks in bursts	0.5	2.9	3.7	-1.7	1.7	1.9	1.5
Mean num. licks in bursts	0.9	2.5	3.1	1.5	-1.8	-1.7	-1.2
Cd content in liver	2.3	2.6	4.4	-1.4	1.7	2.1	1.1
Co content in liver	1.4	1.6	2.2	-1.0	1.1	1.4	1.5
Cu content in liver	1.2	1.4	2.5	-0.6	1.4	1.6	0.9
Fe content in liver	1.5	1.8	2.2	-1.5	1.4	1.4	1.0
K content in liver	0.2	0.2	0.5	-0.7	0.6	0.0	-0.2
Mg content in liver	0.4	0.4	0.6	-0.8	0.8	0.5	0.6
Mn content in liver	0.9	1.1	1.6	-0.9	1.3	1.2	0.6
Na content in liver	1.2	1.4	2.5	-1.6	1.1	0.7	1.1
Rb content in liver	0.2	0.2	0.4	0.3	-0.6	-0.6	0.0
Se content in liver	24.4	28.8	35.8	-5.5	6.0	5.9	3.8
Sr content in liver	0.6	0.5	1.3	-0.1	0.5	0.7	1.2
Zn content in liver	6.0	7.0	9.7	-3.1	3.1	2.7	1.4
Bone: minimum diameter	5.5	10.6	14.3	3.4	-3.8	-3.2	-2.6
Time in familiar zone, hab. session 1	0.0	0.0	0.1	0.3	-0.2	-0.0	-0.2
Time in novel zone, hab. session 1	0.5	0.5	0.6	-0.7	0.8	0.7	0.7
Total zone transitions, hab. session 1	0.1	0.1	0.2	0.5	-0.3	-0.3	-0.4
Total locomotion distance, hab. session 1	0.3	0.4	0.5	-0.7	0.7	0.4	0.7
Locomotion velocity, hab. session 1	0.5	0.6	1.0	-1.0	0.8	0.4	0.8
Time in familiar zone, hab. session 2	0.4	0.5	0.7	-0.6	0.7	0.8	0.6
Time in novel zone, hab. session 2	0.1	0.1	0.1	0.3	-0.2	-0.2	-0.1
Total zone transitions, hab. session 2	0.4	0.6	0.9	-0.7	0.7	0.9	0.6
Total locomotion distance, hab. session 2	0.7	0.9	1.0	-1.0	0.9	0.9	1.0
Locomotion velocity, hab. session 2	0.5	0.7	0.9	-1.0	0.9	0.8	0.8
Novel to familiar place preference ratio	1.3	1.7	2.7	1.6	-1.1	-1.3	-1.1
Novelty place preference	1.4	1.8	3.0	1.7	-1.1	-1.3	-1.0
Time in novel zone, NPP test	1.1	1.3	2.3	1.5	-0.8	-1.1	-1.0
Total zone transitions, NPP test	0.5	0.7	1.2	-1.1	0.9	0.8	0.2
Total locomotion distance, NPP test	1.1	1.5	2.3	-1.5	1.3	1.0	1.0
Locomotion velocity, NPP test	0.8	1.2	2.1	-1.4	1.1	0.8	0.9
Intraocular pressure	0.2	0.4	0.7	0.8	-0.7	-0.5	0.3
Delta distance traveled before/after self-admin	2.2	2.4	4.2	2.1	-1.6	-1.5	-0.8
Delta ambulatory time before/after self-admin	1.6	2.8	4.4	2.1	-1.8	-1.7	-0.7
Parametrial fat weight	0.4	0.9	1.7	-1.3	1.0	0.9	0.2
Pavlov. Cond. lever latency	0.3	0.3	1.0	1.0	-0.4	0.0	0.4
Pavlov. Cond. magazine entry latency	1.2	1.5	3.0	-1.7	1.2	1.2	0.5
Pavlov. Cond. change in total contacts	2.0	2.2	3.6	-1.9	1.4	1.5	0.9
Pavlov. Cond. index score	0.6	0.7	2.2	-1.5	0.7	0.5	0.0
Pavlov. Cond. latency score	0.4	0.6	1.8	-1.4	0.5	0.2	-0.2
Pavlov. Cond. lever contacts	0.5	0.6	1.6	-1.3	0.8	0.4	-0.1
Pavlov. Cond. magazine entry number	0.7	0.9	1.6	1.3	-0.9	-1.1	-0.1
Pavlov. Cond. intertrial magazine entries	0.6	0.7	1.2	0.7	-1.0	-1.1	-0.1
Pavlov. Cond. lever-magazine prob. diff.	0.9	1.2	2.9	-1.7	1.0	0.8	0.2
Pavlov. Cond. response bias	1.4	1.8	2.8	-1.7	1.4	1.5	0.6
Pavlov. Cond. lever latency	0.2	0.2	0.8	0.2	-0.1	-0.3	-0.9
Pavlov. Cond. magazine entry latency	1.2	1.7	2.4	-1.6	1.2	1.1	1.3
Pavlov. Cond. change in total contacts	0.1	0.3	0.6	-0.8	0.2	0.0	0.7
Pavlov. Cond. index score	0.2	0.3	0.7	-0.6	0.2	0.2	0.8
Pavlov. Cond. latency score	0.1	0.2	0.6	-0.4	-0.0	0.0	0.8
Pavlov. Cond. lever contacts	0.2	0.3	0.9	-0.3	0.1	0.3	0.9
Pavlov. Cond. magazine entry number	1.6	2.1	3.3	1.8	-1.3	-1.2	-1.4
Pavlov. Cond. intertrial magazine entries	0.8	1.7	2.4	1.1	-1.4	-1.5	-1.1
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.4	0.8	-0.7	0.3	0.3	0.9
Pavlov. Cond. response bias	0.7	1.0	1.4	-1.1	0.8	0.9	1.2
Time in closed arm before self-admin	0.0	0.0	0.1	-0.2	0.3	-0.0	0.1
Time in closed arm after self-admin	1.4	1.6	2.6	-1.6	1.4	1.0	1.0
Time in open arm before self-admin	0.1	0.1	0.3	0.3	0.3	0.6	0.3
Time in open arm after self-admin	0.7	0.7	1.2	1.1	-0.9	-0.8	-0.5
Bone: periosteal estimation	5.1	12.2	16.2	3.8	-4.0	-3.5	-2.5
Bone: periosteal perimeter	4.8	9.4	11.5	3.1	-3.4	-3.1	-2.6
Bone: post-yield work	1.5	2.7	3.9	1.7	-2.0	-1.4	-1.3
Progressive ratio test 1 active lever presses	1.8	3.2	5.8	2.4	-1.9	-1.5	-1.1
Progressive ratio test 1 breakpoint	1.6	2.8	5.0	2.2	-1.7	-1.4	-1.0
Progressive ratio test 1 inactive lever presses	1.0	2.7	6.1	2.5	-1.2	-0.9	-1.5
Progressive ratio test 2 active lever presses	5.4	7.7	14.1	3.8	-2.7	-2.2	-2.1
Progressive ratio test 2 breakpoint	6.3	8.0	14.7	3.8	-2.8	-2.3	-2.1
Progressive ratio test 2 inactive lever presses	1.1	3.5	7.4	2.7	-1.5	-1.3	-1.6
Incentive Sensitization - Responses	2.1	5.7	11.0	3.3	-2.1	-1.7	-2.2
Incentive Sensitization - Breakpoint	2.7	6.1	11.5	3.4	-2.2	-1.8	-2.2
Sum of active levers in priming session hrs 5-6	0.8	0.7	1.1	-0.7	1.1	0.9	0.7
Progressive ratio	0.0	0.1	0.2	-0.5	-0.1	-0.3	0.1
Food seeking constrained by brief footshock	1.5	1.9	2.4	1.4	-1.4	-1.1	-1.5
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	0.4	-0.1	0.2	-0.3
Retroperitoneal fat weight	0.0	0.1	0.3	0.3	-0.5	-0.4	0.3
Reaction time number correct	0.7	2.5	3.2	1.4	-1.6	-1.8	-1.6
Reaction time mean minus median	0.0	0.2	0.3	0.6	-0.1	0.4	-0.4
Reaction time mean minus median AUC	0.0	0.2	0.4	0.1	0.3	0.7	0.2
Reaction time num false alarms	0.6	0.9	1.8	0.5	-1.1	-1.3	-0.6
Reaction time num false alarms AUC	0.2	0.4	0.8	0.2	-0.8	-0.9	-0.4
Reaction time trials correct on left	0.7	2.5	3.2	1.4	-1.6	-1.8	-1.6
Reaction time trials on left	0.7	2.4	3.1	1.4	-1.6	-1.8	-1.5
Reaction time mean	1.7	3.7	4.9	-1.7	1.9	2.2	1.8
Reaction time mean AUC	1.9	4.5	6.1	-1.9	2.2	2.5	1.8
Median of all reaction times	3.2	5.1	5.8	-2.1	2.3	2.4	2.2
Reaction time omissions	0.2	0.4	0.8	-0.6	0.3	0.5	0.9
Reaction time false alarm rate	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2
Reaction time premature initiation rate	1.1	1.7	2.4	1.4	-1.2	-1.1	-1.5
Reaction time premature initiations	1.7	5.3	6.0	2.3	-2.3	-2.2	-2.4
Std. dev. reaction times	0.3	1.0	2.1	-0.5	0.9	1.4	0.9
Reaction time trials completed	0.7	2.4	3.1	1.4	-1.6	-1.8	-1.5
Reaction time trials AUC	0.6	2.0	2.6	1.1	-1.4	-1.6	-1.4
Run reversals in cocaine runway, females	0.1	0.1	0.1	0.2	0.3	0.3	-0.2
Run reversals in cocaine runway, males	0.2	0.2	0.3	-0.5	0.4	0.5	-0.1
Latency to leave start box in cocaine runway	0.7	0.9	1.6	0.6	-1.2	-1.2	0.6
Latency to leave start box in cocaine runway, F	0.3	0.3	0.6	0.3	-0.6	-0.8	0.5
Latency to leave start box in cocaine runway, M	0.8	0.8	1.3	0.8	-1.1	-1.1	0.0
Std. dev. time between licks in bursts	2.1	4.0	4.8	-1.9	2.1	2.2	1.8
Total sessions with >9 infusions	0.2	0.3	1.0	1.0	0.1	0.4	-0.2
Short access day 1 total inactive lever presses	0.6	1.2	3.3	1.8	-0.9	-0.8	-0.1
Short access day 10 total inactive lever presses	0.0	0.2	0.4	-0.6	0.5	0.2	0.1
Short access day 1 total infusions	0.1	0.2	0.6	0.8	0.2	0.4	0.1
Short access day 10 total infusions	0.2	0.3	0.5	0.7	0.4	0.6	-0.4
Short access total infusions	1.0	1.4	3.6	1.9	-0.7	-0.5	-1.1
Short access day 1 locomotion	0.2	0.3	0.4	0.6	0.5	0.6	0.2
Short access day 10 total locomotion	0.0	0.1	0.2	-0.4	0.4	0.2	-0.0
Short access total locomotion	0.3	0.5	0.9	-0.1	0.9	0.9	0.5
One hour access (0.3 mA shock)	8.1	9.6	16.8	4.1	-3.0	-2.4	-2.6
Compulsive drug intake	0.1	0.2	0.3	0.3	-0.6	-0.5	-0.1
One hour access (shock baseline)	1.9	5.0	9.0	3.0	-1.9	-1.5	-2.2
Social response proportion	0.2	0.2	0.4	0.6	-0.3	-0.5	-0.5
Social responses	1.1	1.4	2.9	1.7	-0.8	-0.6	-1.3
Social time	0.5	0.8	1.4	-0.8	1.1	1.2	0.1
Soleus weight	0.8	2.2	3.3	1.8	-1.8	-1.5	-0.6
Bone: stiffness	2.5	4.6	5.7	1.9	-2.4	-2.1	-2.1
Tibialis anterior weight	0.9	3.0	5.4	0.7	-1.6	-2.3	-1.9
Time to tail flick, vehicle, before self-admin	0.3	0.4	0.7	-0.2	0.7	0.6	0.8
Time to tail flick, vehicle, after self-admin	0.2	0.5	1.1	0.2	-0.3	-0.8	-1.1
Time to tail flick, test, before self-admin	0.9	1.0	1.7	0.8	-1.3	-1.3	-0.1
Time to tail flick, test, after self-admin	1.0	1.1	1.4	-1.2	1.2	0.8	1.0
Delta time to tail flick, vehicle, before/after SA	2.5	2.7	3.8	0.9	-1.6	-2.0	-1.9
Delta time to tail flick, test, before/after SA	0.5	0.6	1.2	-0.7	1.1	0.9	-0.0
Tibia length	0.1	0.2	0.3	0.4	-0.6	-0.3	-0.4
Ambulatory time before self-admin	0.3	0.9	1.5	-1.2	0.9	0.7	0.8
Ambulatory time after self-admin	0.4	0.7	1.1	0.9	-0.8	-1.1	0.3
Bone: tissue strength	0.4	0.4	1.0	-0.3	0.7	1.0	0.0
Total heroin consumption	1.6	1.8	3.0	1.5	-1.0	-1.1	-1.7
Bone: trabecular number	4.2	7.9	12.2	3.5	-3.0	-2.6	-1.9
Bone: trabecular spacing	1.8	2.6	4.9	-2.2	1.7	1.5	0.6
Bone: trabecular thickness	3.9	5.4	7.7	2.8	-2.6	-2.2	-1.5
Bone: trabecular tissue density	1.4	2.4	3.4	1.7	-1.7	-1.8	-0.6
Water consumed over 24 hours	0.1	0.2	0.3	-0.4	-0.1	-0.6	-0.4
Number of responses in last shaping day	0.3	0.4	1.2	1.1	0.0	0.6	0.4