Hub : Genes

LOC102553657

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 pVTA gene expression LOC102553657 0.07 0.04 1.6e-05 0.03 0.06 0.07 0.06 9.3e-04 8.2e-06 2.5e-06 1.8e-05
2 LHb gene expression LOC102553657 0.23 0.17 6.9e-03 0.02 0.08 0.05 0.05 9.7e-02 5.0e-03 2.0e-02 3.1e-02
3 BLA gene expression LOC102553657 0.21 0.11 3.6e-09 0.19 0.16 0.16 0.18 2.5e-10 8.6e-09 6.3e-09 5.2e-10
4 OFC gene expression LOC102553657 0.35 0.17 1.2e-04 0.15 0.15 0.1 0.11 1.7e-04 2.5e-04 2.2e-03 1.7e-03
5 IL gene expression LOC102553657 0.43 0.2 2.6e-05 0.17 0.17 0.18 0.19 6.4e-05 5.4e-05 4.2e-05 2.7e-05
6 PL gene expression LOC102553657 0.25 0.1 0.0e+00 0.26 0.24 0.26 0.26 1.0e-27 1.4e-26 6.6e-28 2.2e-28
7 IC gene expression LOC102553657 0.15 0.08 5.3e-06 0.1 0.08 0.13 0.13 4.8e-05 2.3e-04 3.7e-06 4.3e-06
8 NAcc gene expression LOC102553657 0.17 0.08 0.0e+00 0.18 0.19 0.18 0.19 5.6e-27 1.8e-27 7.7e-27 4.4e-28
9 Brain gene expression LOC102553657 0.35 0.14 0.0e+00 0.27 0.26 0.28 0.27 4.9e-25 3.8e-24 9.9e-26 7.8e-25
10 Liver gene expression LOC102553657 0.45 0.17 0.0e+00 0.32 0.17 0.33 0.13 1.3e-35 7.5e-19 8.5e-38 6.7e-14

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10
Bone: apparent density1.93.34.9-2.1-2.2-1.9-1.9-1.9-1.9-1.7-1.8-1.40.8
Area under the delay curve1.41.62.3-1.2-1.5-1.5-1.3-1.3-1.4-1.2-1.4-1.1-0.1
BMI with tail2.79.128.6-5.3-3.1-2.1-2.2-2.2-2.1-2.0-1.7-1.55.1
BMI without tail1.23.813.5-3.2-1.6-1.3-1.3-1.3-1.3-1.3-1.2-1.23.7
Body weight3.314.440.4-6.4-4.0-2.9-2.9-2.9-2.9-2.9-2.5-2.15.9
Weight adjusted by age0.71.05.5-1.70.10.80.50.50.50.10.3-0.42.3
Bone surface0.30.51.2-1.1-1.0-0.7-0.6-0.6-0.7-0.7-0.6-0.30.8
Bone volume1.42.65.9-2.4-2.0-1.4-1.5-1.5-1.5-1.4-1.3-0.91.7
Breakpoint value in progressive ratio session2.32.73.4-1.5-1.7-1.7-1.7-1.7-1.7-1.8-1.8-1.7-0.8
Number of licking bursts1.42.33.0-1.3-1.7-1.6-1.6-1.6-1.6-1.6-1.7-1.4-0.4
Context. condit. distance diff. score1.01.22.21.41.50.90.90.91.01.41.10.90.5
Locomotion velocity, session 10.70.73.50.9-0.3-0.8-0.7-0.7-0.7-0.3-0.6-0.5-1.9
Locomotion distance, session 10.40.51.61.30.70.50.50.50.61.00.70.60.1
Locomotion velocity, session 22.52.93.92.01.61.71.71.71.72.01.81.80.5
Locomotion distance, session 20.40.52.4-0.9-0.8-0.6-0.6-0.6-0.6-0.2-0.4-0.31.5
Locomotion velocity, session 30.20.30.60.80.50.30.30.30.40.60.20.60.7
Locomotion distance, session 31.01.12.20.91.30.80.70.70.91.50.90.71.5
Stereotopy head waving bouts, day 30.20.20.6-0.8-0.5-0.2-0.4-0.4-0.3-0.4-0.5-0.40.1
Stereotopy head waving duration, day 30.40.41.9-0.0-0.4-0.4-0.5-0.5-0.5-0.7-0.7-0.7-1.4
Locomotion velocity, session 70.10.10.1-0.2-0.3-0.3-0.3-0.3-0.3-0.3-0.4-0.30.2
Locomotion distance, session 70.30.40.80.90.60.50.60.60.60.80.60.60.5
Stereotopy head waving bouts, day 70.10.20.2-0.4-0.4-0.5-0.5-0.5-0.5-0.4-0.4-0.3-0.1
Stereotopy head waving duration, day 70.60.81.1-1.0-1.0-0.9-0.9-0.9-0.9-1.1-0.9-0.6-0.1
Locomotion velocity, session 80.70.92.31.50.81.00.90.90.90.90.70.9-0.5
Locomotion distance, session 80.71.02.01.41.10.80.80.80.91.31.00.90.8
Degree of sensitization distance0.60.62.60.0-0.8-0.6-0.5-0.5-0.6-0.9-0.6-0.5-1.6
Degree of sensitization stereotypy0.50.50.7-0.6-0.7-0.8-0.8-0.8-0.8-0.8-0.7-0.6-0.2
Conditioned locomotion0.00.00.10.30.10.10.10.10.10.20.20.20.3
Cocaine response after cond. corrected1.72.03.21.71.81.61.61.61.51.21.20.8-0.4
Cocaine response after cond. not corrected1.82.23.81.91.81.61.61.61.51.21.20.9-1.0
Cocaine response before conditioning0.20.31.4-0.1-0.5-0.5-0.4-0.4-0.4-0.4-0.4-0.2-1.2
Saline control response0.70.92.01.41.00.90.80.80.91.21.10.8-0.4
Bone: connectivity density0.00.00.10.2-0.2-0.2-0.2-0.2-0.2-0.1-0.2-0.1-0.1
Bone: cortical apparent density6.28.511.03.03.33.03.13.13.13.33.22.60.6
Bone: cortical area3.55.39.9-3.1-2.6-2.3-2.2-2.2-2.3-2.3-2.1-1.81.8
Bone: cortical porosity0.91.01.6-0.4-1.0-1.3-1.2-1.2-1.2-1.0-1.2-0.7-0.4
Bone: cortical porosity2.12.33.2-1.1-1.5-1.8-1.7-1.7-1.7-1.6-1.7-1.2-0.3
Bone: cortical thickness0.91.54.0-1.7-1.3-1.0-1.0-1.0-1.0-1.0-0.9-0.72.0
Bone: cortical thickness0.40.43.0-0.9-0.5-0.2-0.2-0.2-0.2-0.00.10.21.7
Bone: cortical tissue density6.38.611.03.13.33.03.13.13.13.33.22.60.5
Condit. Reinf. active minus inactive responses0.50.61.50.20.2-0.9-0.9-0.9-0.8-0.3-0.7-1.2-0.7
Condit. Reinf. active-inactive response ratio0.30.31.00.50.4-0.6-0.5-0.5-0.5-0.0-0.4-0.9-1.0
Condit. Reinf. active responses1.61.93.5-0.9-0.7-1.7-1.7-1.7-1.6-1.0-1.5-1.9-0.3
Condit. Reinf. inactive responses2.12.53.4-1.5-1.4-1.9-1.8-1.8-1.8-1.4-1.7-1.70.1
Incentive salience index mean0.40.61.50.50.4-0.7-0.6-0.6-0.6-0.2-0.6-1.2-1.2
Condit. Reinf. lever presses0.30.41.90.40.1-0.5-0.5-0.5-0.5-0.3-0.5-0.9-1.4
Condit. Reinf. active minus inactive responses4.55.89.1-1.0-1.6-2.6-2.6-2.6-2.6-2.5-2.7-3.0-2.3
Condit. Reinf. active-inactive response ratio2.32.64.9-0.2-0.6-1.6-1.7-1.7-1.6-1.6-1.8-2.1-2.2
Condit. Reinf. active responses5.17.110.3-1.7-2.2-2.8-2.9-2.9-2.8-2.9-3.0-3.2-1.8
Condit. Reinf. inactive responses1.52.02.6-1.3-1.5-1.4-1.4-1.4-1.5-1.6-1.6-1.5-0.2
Condit. Reinf. lever presses2.53.44.4-1.2-1.6-2.0-2.1-2.1-2.1-1.9-1.9-2.0-1.4
Condit. Reinf. lever reinforcers received4.76.59.8-1.5-2.0-2.7-2.8-2.8-2.7-2.7-2.8-3.1-1.8
Conditioned reinforcement - actives0.50.81.3-0.4-0.7-1.0-1.1-1.1-1.0-0.8-1.0-1.0-0.7
Conditioned reinforcement - inactives0.91.31.6-1.3-1.0-1.2-1.2-1.2-1.2-1.2-1.2-1.30.1
Conditioned locomotion0.30.41.10.40.10.70.60.60.60.80.71.00.4
Patch foraging indifference point 0 sec0.91.63.8-2.0-1.2-1.2-1.1-1.1-1.1-1.0-0.9-1.01.7
Patch foraging indifference point AUC2.43.55.4-1.9-2.3-2.0-1.9-1.9-2.0-2.0-2.0-1.4-0.6
Delay disc. indifference point, 0s delay0.50.51.1-1.0-1.0-0.6-0.6-0.6-0.6-0.6-0.5-0.01.1
Delay disc. indifference point, 16s delay1.11.21.7-0.7-1.3-1.3-1.1-1.1-1.2-1.2-1.2-1.0-0.7
Delay disc. indifference point, 2s delay0.00.00.1-0.0-0.3-0.2-0.0-0.0-0.10.10.00.40.3
Delay disc. indifference point, 24s delay3.33.75.3-1.7-2.3-2.1-2.0-2.0-2.1-2.0-2.1-1.9-0.9
Delay disc. indifference point, 4s delay0.50.50.8-0.3-0.5-0.9-0.7-0.7-0.8-0.7-0.9-0.8-0.2
Delay disc. indifference point, 8s delay2.73.24.9-2.1-2.2-1.9-1.8-1.8-1.9-1.7-1.9-1.60.4
Indifference point function ln k0.50.91.91.41.11.11.01.01.00.90.90.60.2
Indifference point function log k0.50.91.91.41.11.11.01.01.00.90.90.60.2
Patch foraging total patch changes 0 sec1.12.14.6-2.1-1.5-1.5-1.4-1.4-1.4-1.3-1.1-1.11.5
Patch foraging total patch changes 12 sec2.22.94.2-1.7-1.9-2.0-1.9-1.9-1.9-1.6-1.7-1.40.4
Patch foraging total patch changes 18 sec4.77.19.7-2.9-3.1-3.0-2.8-2.8-2.9-2.7-2.7-2.20.4
Patch foraging total patch changes 24 sec4.37.48.9-2.7-2.8-3.0-2.9-2.9-2.9-3.0-3.0-2.5-0.3
Patch foraging total patch changes 6 sec2.43.76.9-2.6-2.2-2.1-1.8-1.8-1.9-1.7-1.6-1.51.5
Patch foraging time to switch 0 sec0.71.52.91.71.51.21.31.31.21.21.11.0-0.3
Patch foraging water rate 0 sec0.40.91.6-1.3-1.1-1.1-1.1-1.1-1.0-0.7-0.7-0.60.7
Patch foraging water rate 12 sec0.51.12.0-1.4-1.2-1.1-1.1-1.1-1.1-0.9-0.9-1.00.6
Patch foraging water rate 18 sec0.10.11.0-0.50.00.20.10.10.20.20.2-0.11.0
Patch foraging water rate 24 sec0.91.32.7-1.6-1.2-1.2-1.1-1.1-1.1-0.8-0.8-0.71.4
Patch foraging water rate 6 sec0.20.31.20.00.00.10.10.10.20.80.60.91.1
Seeking ratio, delayed vs. immediate footshock0.10.10.30.5-0.20.20.10.10.20.20.10.50.1
Distance traveled before self-admin5.26.88.81.92.73.02.82.82.92.72.82.71.2
Distance traveled after self-admin3.24.05.60.81.52.42.22.22.31.92.22.31.5
Extensor digitorum longus weight0.41.82.5-1.6-1.4-1.6-1.4-1.4-1.4-1.1-1.2-0.81.1
Bone: elastic displacement0.10.10.40.0-0.2-0.3-0.4-0.4-0.4-0.4-0.5-0.6-0.0
Bone: elastic work0.50.63.6-0.10.40.50.50.50.50.60.70.61.9
Bone: endosteal estimation1.43.16.7-2.6-2.0-1.7-1.7-1.7-1.7-1.8-1.6-1.31.0
Bone: endosteal perimeter1.32.97.5-2.7-2.0-1.5-1.5-1.5-1.5-1.6-1.4-1.11.5
Epididymis fat weight5.920.241.7-6.5-4.8-4.1-4.3-4.3-4.3-4.5-4.2-4.03.5
Delta time in closed arm before/after self-admin1.11.01.30.11.01.21.11.11.11.11.10.80.7
Delta time in open arm before/after self-admin1.61.62.6-1.3-1.6-1.2-1.2-1.2-1.3-1.6-1.3-1.1-0.4
Diff in mean of infusions in LGA sessions0.30.41.41.00.90.20.10.10.20.20.0-0.7-1.2
Delay discount exponential model param1.61.82.61.31.61.61.41.41.51.31.51.20.1
Extinction: sum of active levers before priming1.82.02.4-0.8-1.6-1.4-1.4-1.4-1.4-1.5-1.5-1.4-1.4
Active lever presses in extinction session 60.30.30.8-0.9-0.9-0.4-0.4-0.4-0.5-0.6-0.5-0.20.1
Bone: final force0.71.12.6-1.6-1.1-1.1-1.0-1.0-1.0-0.8-0.7-0.61.1
Bone: final moment1.01.63.4-1.9-1.4-1.3-1.3-1.3-1.2-0.9-1.0-0.81.3
Food consumed during 24 hour testing period0.10.10.60.50.3-0.2-0.2-0.2-0.00.50.10.20.8
Glucose0.40.64.0-0.8-0.00.10.20.20.20.50.60.52.0
Heart weight0.91.43.2-1.8-0.6-1.0-1.0-1.0-1.0-0.9-1.0-1.51.4
Delay discount hyperbolic model param1.11.21.81.11.31.31.11.11.21.01.21.1-0.0
Intermittent access intake day 1-15 change0.71.43.3-1.8-1.1-1.0-1.0-1.0-1.0-1.2-1.1-1.11.1
Intermittent access intake escalation0.71.53.6-1.9-1.2-1.0-1.1-1.1-1.0-1.2-1.2-1.21.0
Intermittent access intake escalation 20.70.81.9-1.4-1.0-0.8-0.8-0.8-0.8-1.0-0.9-0.70.8
Intermitt. access day 1 inactive lever presses1.34.87.1-2.5-2.7-2.2-2.3-2.3-2.3-2.3-2.2-2.0-0.0
Intermitt. access day 15 inactive lever presses0.30.72.1-0.8-0.3-0.6-0.7-0.7-0.7-0.9-1.0-1.4-0.6
Intermitt. access escalation Index0.20.31.00.20.00.30.40.40.40.70.61.00.9
Intermittent access day 1 total infusions1.01.62.1-1.0-1.4-1.4-1.4-1.4-1.4-1.1-1.2-1.4-0.4
Intermittent access day 15 total infusions1.42.13.2-1.6-1.4-1.5-1.5-1.5-1.5-1.5-1.6-1.80.2
Intermittent access terminal intake (last 3 days)0.71.01.2-1.0-1.0-1.0-1.1-1.1-1.0-0.9-1.0-1.10.2
Intermittent access total infusions1.72.02.5-1.4-1.6-1.4-1.5-1.5-1.5-1.4-1.4-1.5-0.0
Intermittent access day 1 locomotion0.30.40.60.30.60.70.70.70.70.70.70.40.6
Intermittent access day 15 total locomotion0.30.62.1-1.5-1.0-0.3-0.3-0.3-0.4-0.8-0.6-0.61.1
Intermittent access total locomotion0.50.61.3-0.10.20.90.90.90.80.60.70.51.1
Intermittent access standard deviation1.22.43.1-1.7-1.7-1.7-1.7-1.7-1.6-1.5-1.5-1.7-0.1
Left kidney weight0.73.020.9-1.50.20.90.90.91.01.11.11.24.6
Right kidney weight0.73.124.7-2.3-0.10.20.10.10.20.50.50.55.0
Cocaine induced anxiety2.94.15.42.32.12.12.22.22.11.92.02.2-0.4
Post-drug Anxiety0.20.20.50.40.30.50.50.50.40.30.40.7-0.0
Baseline Anxiety4.45.16.3-2.4-2.4-2.5-2.5-2.5-2.4-2.3-2.3-2.10.0
Tail length0.10.40.7-0.5-0.5-0.5-0.5-0.5-0.5-0.8-0.8-0.80.8
Length with tail0.52.36.7-2.2-1.7-1.2-1.1-1.1-1.1-1.3-1.1-0.82.6
Length without tail2.37.317.5-4.2-3.3-2.3-2.4-2.4-2.3-2.4-2.1-1.53.0
Times rat made contact with spout0.70.82.5-0.9-1.0-1.0-0.9-0.9-0.8-0.2-0.4-0.11.6
Lifetime Intake2.02.43.0-1.6-1.7-1.6-1.7-1.7-1.6-1.5-1.6-1.7-0.1
Liver weight, left1.83.08.4-2.9-2.1-1.4-1.4-1.4-1.5-1.7-1.4-1.01.9
Liver weight, right1.52.615.0-2.7-1.4-0.6-0.5-0.5-0.5-0.4-0.20.23.9
Locomotor activity0.60.92.5-0.30.71.01.01.01.00.60.81.11.6
Locomotor testing distance1.62.83.80.31.51.81.81.81.81.51.71.82.0
Locomotor testing rearing0.51.11.8-0.10.81.21.21.21.10.81.01.11.3
Locomotion in novel chamber2.83.65.21.51.81.81.81.81.92.12.12.31.6
Locomotion in novel chamber post-restriction0.50.92.31.51.30.80.80.80.81.00.80.7-0.6
Fecal boli incidents, locomotor time 10.10.10.2-0.1-0.4-0.0-0.1-0.1-0.1-0.4-0.5-0.2-0.4
Change in fecal boli incidents, locomotor task0.20.20.60.10.70.40.40.40.4-0.2-0.2-0.5-0.3
Time >=10cm from walls, locomotor time 10.40.40.80.90.50.70.70.70.70.50.40.7-0.6
Bouts of movement, locomotor time 13.54.04.9-2.2-2.2-2.0-2.0-2.0-2.1-2.1-2.1-2.1-0.2
Total resting periods, locomotor time 13.13.54.4-2.1-2.1-1.9-1.9-1.9-1.9-2.0-1.9-2.1-0.2
Rest time, locomotor task time 10.10.10.4-0.7-0.10.10.10.10.0-0.2-0.1-0.40.4
Distance moved, locomotor task time 10.10.10.30.4-0.0-0.1-0.1-0.1-0.10.50.30.60.2
Vertical activity count, locomotor time 11.12.73.81.92.01.71.71.71.71.81.61.50.4
Time >=10cm from walls, locomotor time 20.20.31.3-1.1-0.8-0.3-0.3-0.3-0.4-0.8-0.6-0.40.2
Bouts of movement, locomotor time 20.10.10.60.80.4-0.0-0.0-0.00.00.00.00.2-0.6
Total resting periods, locomotor time 20.00.10.20.40.1-0.2-0.2-0.2-0.2-0.2-0.2-0.0-0.5
Rest time, locomotor task time 20.60.81.81.00.60.80.80.80.81.01.01.40.6
Distance moved, locomotor task time 21.11.31.7-1.0-0.9-1.3-1.3-1.3-1.3-1.3-1.2-1.2-0.6
Vertical activity count, locomotor time 20.10.10.2-0.5-0.3-0.2-0.3-0.3-0.3-0.4-0.4-0.30.1
Light reinforcement 10.20.51.90.90.60.70.60.60.60.10.10.2-1.4
Light reinforcement 20.60.92.11.51.00.90.90.90.90.70.70.7-1.2
Bone: marrow area1.43.16.8-2.6-2.0-1.7-1.7-1.7-1.7-1.8-1.6-1.31.1
Bone: maximum diameter3.66.814.1-3.8-3.2-2.4-2.4-2.4-2.5-2.8-2.4-1.91.6
Bone: maximum force0.50.91.7-1.3-1.0-1.0-1.0-1.0-0.9-0.6-0.7-0.60.9
Bone: maximum moment0.81.42.3-1.5-1.2-1.3-1.3-1.3-1.2-0.9-1.0-0.91.1
Mean time between licks in bursts0.71.72.7-0.9-0.9-1.5-1.4-1.4-1.4-1.3-1.5-1.6-0.6
Mean num. licks in bursts1.11.83.30.61.21.21.21.21.21.51.61.51.8
Cd content in liver4.44.97.31.72.72.42.42.42.42.42.41.80.7
Co content in liver2.63.04.31.41.82.12.02.02.01.71.71.50.2
Cu content in liver0.20.30.40.30.40.70.60.60.60.50.50.60.2
Fe content in liver1.51.82.3-1.3-1.5-1.4-1.3-1.3-1.4-1.5-1.4-1.40.1
K content in liver0.10.10.20.50.00.40.40.40.40.20.20.5-0.4
Mg content in liver0.00.00.20.2-0.30.10.10.1-0.0-0.2-0.10.0-0.4
Mn content in liver0.10.20.20.50.40.40.40.40.40.40.30.4-0.1
Na content in liver0.30.42.50.9-0.0-0.3-0.2-0.2-0.3-0.2-0.3-0.2-1.6
Rb content in liver0.50.62.10.2-0.4-0.6-0.6-0.6-0.6-0.8-0.9-0.9-1.5
Se content in liver0.40.41.81.30.30.40.40.40.40.30.30.5-1.2
Sr content in liver3.22.83.92.01.71.81.81.81.81.71.61.4-0.5
Zn content in liver1.11.31.61.11.01.21.31.31.21.21.21.10.1
Bone: minimum diameter2.03.77.6-2.8-2.1-1.8-1.8-1.8-1.9-2.0-1.8-1.61.3
Time in familiar zone, hab. session 12.92.83.81.41.82.02.02.01.91.51.61.50.1
Time in novel zone, hab. session 13.23.24.1-1.5-2.0-2.0-2.0-2.0-2.0-1.8-1.8-1.6-0.2
Total zone transitions, hab. session 10.30.43.0-0.6-0.4-0.4-0.4-0.4-0.30.1-0.10.11.7
Total locomotion distance, hab. session 10.30.51.00.0-0.7-1.0-0.9-0.9-0.9-0.3-0.6-0.40.2
Locomotion velocity, hab. session 10.30.40.90.1-0.6-0.9-0.9-0.9-0.8-0.3-0.6-0.40.2
Time in familiar zone, hab. session 24.24.46.4-2.5-2.1-1.9-2.0-2.0-2.1-2.5-2.4-2.3-0.0
Time in novel zone, hab. session 22.92.94.21.91.81.51.61.61.72.02.01.90.5
Total zone transitions, hab. session 20.50.63.3-1.0-0.4-0.5-0.6-0.6-0.5-0.3-0.4-0.51.8
Total locomotion distance, hab. session 20.40.61.9-0.8-0.6-0.7-0.8-0.8-0.7-0.4-0.5-0.51.4
Locomotion velocity, hab. session 20.20.31.3-0.5-0.4-0.5-0.5-0.5-0.5-0.1-0.3-0.31.1
Novel to familiar place preference ratio0.40.50.9-0.3-0.7-0.9-0.9-0.9-0.9-0.5-0.6-0.6-0.5
Novelty place preference0.50.50.9-0.5-0.8-0.9-0.9-0.9-0.9-0.6-0.6-0.6-0.4
Time in novel zone, NPP test1.31.42.1-1.0-1.2-1.4-1.4-1.4-1.4-1.2-1.1-1.0-0.4
Total zone transitions, NPP test1.11.62.8-1.7-1.3-1.2-1.3-1.3-1.2-0.9-1.1-1.01.4
Total locomotion distance, NPP test1.21.72.3-1.3-1.2-1.4-1.5-1.5-1.4-1.0-1.2-1.21.1
Locomotion velocity, NPP test0.30.51.3-0.7-0.6-0.7-0.8-0.8-0.7-0.2-0.5-0.51.1
Intraocular pressure3.55.17.5-2.7-1.9-2.4-2.4-2.4-2.4-2.1-2.2-2.50.9
Delta distance traveled before/after self-admin0.30.31.3-1.1-0.9-0.2-0.2-0.2-0.3-0.5-0.2-0.20.7
Delta ambulatory time before/after self-admin1.31.53.2-1.7-1.8-1.2-1.1-1.1-1.2-1.3-1.2-0.90.3
Parametrial fat weight7.317.233.6-5.8-4.6-4.1-4.0-4.0-4.1-4.2-3.9-3.72.3
Pavlov. Cond. lever latency0.40.50.7-0.9-0.8-0.8-0.8-0.8-0.8-0.7-0.5-0.50.4
Pavlov. Cond. magazine entry latency0.30.40.7-0.8-0.6-0.6-0.7-0.7-0.6-0.4-0.6-0.60.6
Pavlov. Cond. change in total contacts0.30.30.40.30.50.60.60.60.60.60.50.60.5
Pavlov. Cond. index score0.10.10.5-0.30.10.30.30.30.30.20.10.10.7
Pavlov. Cond. latency score0.10.10.3-0.10.20.40.40.40.40.30.20.20.6
Pavlov. Cond. lever contacts0.30.40.60.70.70.70.60.60.60.50.30.2-0.7
Pavlov. Cond. magazine entry number0.30.42.40.90.30.30.30.30.2-0.00.20.1-1.6
Pavlov. Cond. intertrial magazine entries0.00.10.2-0.3-0.0-0.2-0.2-0.2-0.2-0.3-0.3-0.40.2
Pavlov. Cond. lever-magazine prob. diff.0.00.00.2-0.30.00.20.20.20.20.2-0.00.00.5
Pavlov. Cond. response bias0.00.10.10.00.30.20.20.20.20.40.10.10.3
Pavlov. Cond. lever latency3.54.76.41.32.02.52.52.52.52.12.12.21.6
Pavlov. Cond. magazine entry latency2.32.83.8-1.9-1.9-2.0-1.9-1.9-1.9-1.6-1.5-1.30.5
Pavlov. Cond. change in total contacts3.76.08.3-1.5-2.2-2.9-2.8-2.8-2.8-2.4-2.5-2.6-1.0
Pavlov. Cond. index score4.05.47.8-1.9-2.3-2.8-2.7-2.7-2.7-2.2-2.2-2.2-0.6
Pavlov. Cond. latency score4.05.27.2-2.0-2.4-2.7-2.6-2.6-2.6-2.2-2.2-2.2-0.5
Pavlov. Cond. lever contacts2.43.34.7-1.0-1.7-2.2-2.1-2.1-2.1-1.7-1.7-1.8-1.1
Pavlov. Cond. magazine entry number2.73.45.01.82.02.22.22.22.11.61.71.5-0.4
Pavlov. Cond. intertrial magazine entries0.10.20.50.10.30.70.60.60.60.10.20.3-0.1
Pavlov. Cond. lever-magazine prob. diff.3.54.66.9-1.7-2.2-2.6-2.6-2.6-2.5-1.9-2.0-2.0-0.5
Pavlov. Cond. response bias3.64.97.4-1.5-2.1-2.7-2.7-2.7-2.6-2.1-2.1-2.2-0.8
Time in closed arm before self-admin0.20.20.60.70.70.50.50.50.40.30.40.1-0.0
Time in closed arm after self-admin0.91.02.41.01.51.11.01.01.00.90.90.5-0.0
Time in open arm before self-admin0.20.20.70.70.10.10.20.20.20.40.30.7-0.8
Time in open arm after self-admin1.41.63.3-1.0-1.8-1.3-1.2-1.2-1.3-1.4-1.2-0.7-0.9
Bone: periosteal estimation2.65.512.4-3.5-2.7-2.2-2.2-2.2-2.2-2.3-2.1-1.72.0
Bone: periosteal perimeter3.35.713.2-3.6-2.9-2.2-2.2-2.2-2.2-2.3-2.0-1.52.1
Bone: post-yield work1.72.53.4-1.1-1.3-1.8-1.8-1.8-1.7-1.4-1.6-1.7-1.3
Progressive ratio test 1 active lever presses2.02.44.0-1.5-1.5-1.5-1.6-1.6-1.6-1.6-1.7-2.0-0.4
Progressive ratio test 1 breakpoint2.02.44.1-1.4-1.5-1.5-1.6-1.6-1.6-1.6-1.7-2.0-0.5
Progressive ratio test 1 inactive lever presses3.44.96.2-2.0-2.3-2.4-2.5-2.5-2.4-2.2-2.3-2.2-0.7
Progressive ratio test 2 active lever presses3.03.55.1-2.2-2.0-1.9-1.9-1.9-1.9-1.8-1.9-2.20.3
Progressive ratio test 2 breakpoint3.03.55.2-2.3-2.0-1.8-1.9-1.9-1.9-1.8-1.8-2.20.4
Progressive ratio test 2 inactive lever presses2.13.44.1-2.0-2.0-1.8-1.9-1.9-1.9-1.9-1.9-2.0-0.2
Incentive Sensitization - Responses1.82.64.0-2.0-1.7-1.7-1.7-1.7-1.7-1.4-1.5-1.60.4
Incentive Sensitization - Breakpoint1.82.33.6-1.9-1.7-1.6-1.6-1.6-1.6-1.4-1.4-1.50.4
Sum of active levers in priming session hrs 5-60.20.20.80.2-0.5-0.5-0.4-0.4-0.5-0.4-0.40.0-0.9
Progressive ratio0.20.31.20.80.0-0.4-0.5-0.5-0.5-0.0-0.2-0.1-1.1
Food seeking constrained by brief footshock2.32.93.9-0.7-1.2-1.9-2.0-2.0-1.9-1.6-1.8-1.8-1.6
Seeking ratio, punishment vs. effort0.30.41.3-1.1-0.6-0.5-0.5-0.5-0.4-0.7-0.7-0.80.3
Retroperitoneal fat weight6.728.763.5-8.0-5.9-5.0-5.0-5.0-5.1-5.3-4.8-4.53.9
Reaction time number correct1.12.23.5-1.9-1.7-1.5-1.6-1.6-1.5-1.4-1.4-1.10.7
Reaction time mean minus median0.00.10.4-0.6-0.5-0.0-0.1-0.1-0.1-0.3-0.2-0.10.3
Reaction time mean minus median AUC0.10.30.8-0.40.10.60.50.50.50.20.40.50.9
Reaction time num false alarms0.20.40.8-0.6-0.4-0.7-0.6-0.6-0.6-0.5-0.5-0.9-0.3
Reaction time num false alarms AUC0.10.10.3-0.4-0.1-0.4-0.3-0.3-0.3-0.2-0.2-0.5-0.1
Reaction time trials correct on left1.12.23.5-1.9-1.7-1.5-1.6-1.6-1.5-1.4-1.4-1.10.7
Reaction time trials on left1.22.33.6-1.9-1.7-1.5-1.6-1.6-1.6-1.4-1.5-1.20.7
Reaction time mean0.81.32.10.70.91.41.31.31.31.21.31.20.6
Reaction time mean AUC0.91.42.20.91.01.51.41.41.41.11.21.10.1
Median of all reaction times1.62.33.21.11.31.81.71.71.71.71.71.50.6
Reaction time omissions0.10.20.4-0.6-0.2-0.3-0.5-0.5-0.4-0.4-0.3-0.6-0.1
Reaction time false alarm rate0.10.20.50.50.60.20.30.30.20.30.3-0.2-0.7
Reaction time premature initiation rate1.01.42.90.30.61.11.11.11.11.21.21.61.7
Reaction time premature initiations0.40.85.3-0.8-0.30.20.20.20.30.50.51.12.3
Std. dev. reaction times0.10.20.8-0.8-0.40.10.00.00.0-0.2-0.0-0.00.9
Reaction time trials completed1.22.33.6-1.9-1.7-1.5-1.6-1.6-1.6-1.4-1.5-1.20.7
Reaction time trials AUC1.32.43.7-1.9-1.8-1.6-1.7-1.7-1.6-1.5-1.5-1.20.8
Run reversals in cocaine runway, females0.40.41.80.0-0.00.10.10.10.20.90.90.91.3
Run reversals in cocaine runway, males0.30.31.90.60.30.50.30.30.3-0.0-0.1-0.3-1.4
Latency to leave start box in cocaine runway0.50.61.11.00.80.70.80.80.70.50.60.8-0.6
Latency to leave start box in cocaine runway, F1.21.42.01.41.41.41.31.31.30.91.01.1-0.4
Latency to leave start box in cocaine runway, M0.30.31.0-0.5-0.4-1.0-0.5-0.5-0.7-0.5-0.4-0.5-0.2
Std. dev. time between licks in bursts2.23.03.9-0.9-1.5-1.9-1.9-1.9-1.9-1.9-2.0-1.8-1.4
Total sessions with >9 infusions1.11.32.6-1.6-1.1-1.1-1.2-1.2-1.1-1.0-1.0-1.30.8
Short access day 1 total inactive lever presses1.31.73.3-1.7-1.8-1.2-1.2-1.2-1.3-1.5-1.4-0.90.0
Short access day 10 total inactive lever presses0.20.41.1-1.0-0.7-0.6-0.6-0.6-0.6-0.4-0.4-0.30.6
Short access day 1 total infusions0.30.40.7-0.9-0.8-0.6-0.7-0.7-0.6-0.7-0.5-0.50.1
Short access day 10 total infusions0.70.81.3-0.3-0.8-1.1-1.1-1.1-1.0-0.7-0.9-1.1-0.6
Short access total infusions0.91.21.6-1.0-1.1-1.2-1.3-1.3-1.2-1.0-1.0-1.2-0.2
Short access day 1 locomotion0.80.91.5-1.0-1.2-1.0-0.9-0.9-1.0-1.0-1.0-1.0-0.5
Short access day 10 total locomotion1.22.23.00.30.91.61.71.71.61.41.61.61.6
Short access total locomotion0.30.41.1-0.20.40.60.60.60.60.60.60.31.1
One hour access (0.3 mA shock)7.99.113.0-2.7-3.6-3.1-3.2-3.2-3.2-3.2-3.2-2.8-1.3
Compulsive drug intake1.92.23.8-1.1-2.0-1.6-1.6-1.6-1.5-1.7-1.7-0.9-1.0
One hour access (shock baseline)0.30.51.0-0.9-0.7-0.6-0.6-0.6-0.6-0.8-0.7-1.00.1
Social response proportion1.01.15.7-0.70.30.60.70.70.71.01.11.12.4
Social responses2.63.48.0-2.8-2.1-1.6-1.7-1.7-1.7-1.8-1.8-1.61.2
Social time0.30.42.1-1.0-0.20.40.40.40.30.10.30.41.4
Soleus weight0.92.719.9-2.3-0.90.00.10.10.10.20.20.94.5
Bone: stiffness0.00.00.1-0.1-0.1-0.3-0.2-0.2-0.2-0.1-0.2-0.10.1
Tibialis anterior weight0.41.42.3-0.6-1.0-1.5-1.4-1.4-1.4-1.0-1.3-1.1-0.7
Time to tail flick, vehicle, before self-admin0.10.10.4-0.5-0.5-0.1-0.1-0.1-0.10.00.00.10.6
Time to tail flick, vehicle, after self-admin0.10.10.20.3-0.5-0.3-0.4-0.4-0.3-0.0-0.10.3-0.1
Time to tail flick, test, before self-admin1.51.52.10.51.11.31.41.41.31.31.41.21.0
Time to tail flick, test, after self-admin0.90.91.4-0.9-1.2-1.0-1.1-1.1-1.0-1.0-1.0-0.6-0.1
Delta time to tail flick, vehicle, before/after SA0.80.70.9-0.2-0.8-0.9-1.0-1.0-0.9-0.9-0.9-0.8-0.8
Delta time to tail flick, test, before/after SA0.70.71.0-0.5-0.9-0.9-1.0-1.0-1.0-0.8-1.0-0.6-0.2
Tibia length0.41.05.4-0.70.00.90.80.80.80.60.71.02.3
Ambulatory time before self-admin3.65.57.51.32.42.72.52.52.62.42.52.31.5
Ambulatory time after self-admin3.03.55.40.51.02.32.12.12.11.72.12.31.7
Bone: tissue strength0.10.10.40.20.3-0.1-0.1-0.1-0.1-0.2-0.4-0.6-0.7
Total heroin consumption2.52.94.8-2.2-1.5-1.8-1.8-1.8-1.8-1.7-1.7-2.10.4
Bone: trabecular number1.01.72.1-1.2-1.5-1.4-1.4-1.4-1.4-1.3-1.4-1.2-0.1
Bone: trabecular spacing0.00.10.40.30.2-0.00.00.0-0.0-0.00.1-0.1-0.6
Bone: trabecular thickness3.24.08.6-2.9-2.7-1.8-1.9-1.9-1.9-2.1-1.8-1.21.4
Bone: trabecular tissue density0.81.11.70.90.81.31.31.31.20.91.21.1-0.0
Water consumed over 24 hours0.30.52.50.20.10.30.30.30.40.70.50.91.6
Number of responses in last shaping day0.30.31.0-0.4-0.1-0.6-0.7-0.7-0.6-0.3-0.4-1.0-0.1