Hub : Genes

LOC102553539

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Liver intron excision ratio chr7_27999133_27999512 0.13 0.05 2.1e-15 0.1 0.1 0.1 0.1 1.9e-11 1.2e-11 2.0e-11 3.0e-11
2 Liver mRNA stability LOC102553539 0.09 0.04 6.9e-09 0.05 0.06 0.05 0.04 2.7e-06 2.8e-07 3.9e-06 1.1e-05
3 Liver intron excision ratio chr7_27999133_27999838 0.17 0.07 2.1e-15 0.06 0.11 0.1 0.09 1.1e-07 3.3e-12 3.6e-11 2.7e-10
4 Liver gene expression LOC102553539 0.14 0.06 1.3e-14 0.11 0.09 0.08 0.09 5.6e-12 1.1e-09 2.8e-09 4.6e-10
5 Liver isoform ratio XR_593386.3 0.07 0.03 9.4e-07 0.04 0.05 0.04 0.03 4.8e-05 1.5e-06 3.7e-05 1.2e-04
6 Liver isoform ratio XR_005486853.1 0.08 0.04 2.1e-07 0.04 0.06 0.05 0.04 8.6e-06 3.4e-07 6.2e-06 1.2e-05
7 Liver intron excision ratio chr7_27999997_28004492 0.14 0.05 0.0e+00 0.1 0.17 0.17 0.19 1.1e-10 1.5e-18 1.2e-18 1.8e-20
8 Liver intron excision ratio chr7_27999133_28004492 0.23 0.07 0.0e+00 0.22 0.29 0.29 0.31 2.2e-24 1.9e-32 5.2e-32 1.1e-34

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bone: apparent density0.50.91.9-0.1-1.0-0.90.11.4-1.4-0.81.0
Area under the delay curve0.10.10.50.30.1-0.00.40.1-0.10.30.7
BMI with tail2.16.813.82.8-3.7-3.13.22.6-2.50.40.5
BMI without tail5.110.518.74.0-4.3-4.23.92.8-2.80.80.3
Body weight10.443.575.78.7-8.4-8.48.35.4-5.32.20.3
Weight adjusted by age1.41.62.71.3-1.4-1.51.4-0.40.41.6-1.6
Bone surface0.20.30.70.3-0.8-0.50.40.8-0.8-0.10.5
Bone volume0.71.22.40.6-1.5-1.10.81.5-1.5-0.30.8
Breakpoint value in progressive ratio session0.30.31.0-0.90.61.0-0.4-0.20.2-0.30.3
Number of licking bursts0.20.20.6-0.6-0.3-0.2-0.50.4-0.4-0.80.1
Context. condit. distance diff. score0.81.02.31.0-0.7-0.80.8-0.60.71.5-1.4
Locomotion velocity, session 10.70.81.6-0.41.31.2-0.6-1.11.00.2-0.5
Locomotion distance, session 10.30.30.60.00.40.6-0.1-0.80.80.6-0.7
Locomotion velocity, session 20.20.20.40.4-0.2-0.60.40.5-0.5-0.50.6
Locomotion distance, session 20.30.41.00.6-1.0-0.60.70.7-0.70.3-0.0
Locomotion velocity, session 30.60.72.20.8-0.7-0.21.0-0.40.51.5-1.0
Locomotion distance, session 30.80.91.71.1-1.2-0.91.20.00.01.3-0.8
Stereotopy head waving bouts, day 31.11.32.7-1.61.11.5-1.60.1-0.1-1.10.8
Stereotopy head waving duration, day 30.50.51.3-0.90.81.1-0.90.1-0.1-0.70.6
Locomotion velocity, session 70.91.02.71.7-0.8-0.91.5-0.20.20.9-1.0
Locomotion distance, session 70.30.40.90.9-0.2-0.40.7-0.40.40.7-0.7
Stereotopy head waving bouts, day 70.20.20.60.4-0.0-0.50.40.4-0.5-0.80.4
Stereotopy head waving duration, day 70.20.20.60.00.1-0.20.20.4-0.5-0.80.6
Locomotion velocity, session 80.80.91.71.2-0.8-1.21.3-0.20.31.2-0.7
Locomotion distance, session 82.53.66.42.2-2.2-1.82.2-0.20.32.5-2.1
Degree of sensitization distance0.20.20.6-0.30.80.3-0.5-0.20.2-0.60.3
Degree of sensitization stereotypy0.10.20.80.00.2-0.40.20.2-0.2-0.90.4
Conditioned locomotion0.10.10.20.5-0.10.20.20.4-0.4-0.4-0.1
Cocaine response after cond. corrected0.80.92.80.4-0.2-1.10.11.1-1.1-0.81.7
Cocaine response after cond. not corrected0.30.41.70.2-0.0-0.60.10.5-0.6-0.31.3
Cocaine response before conditioning1.11.32.5-0.70.71.4-0.5-1.51.61.1-1.1
Saline control response0.30.40.80.9-0.4-0.40.70.6-0.6-0.50.6
Bone: connectivity density0.20.40.9-0.60.2-0.3-0.50.5-0.5-0.81.0
Bone: cortical apparent density1.11.52.51.6-1.3-1.51.3-0.00.11.3-1.4
Bone: cortical area1.11.63.21.4-1.8-1.41.21.4-1.40.40.5
Bone: cortical porosity1.21.32.90.5-0.4-0.30.91.6-1.6-0.91.7
Bone: cortical porosity1.11.22.50.7-0.7-0.30.91.6-1.6-0.71.4
Bone: cortical thickness1.01.72.71.4-1.5-1.31.11.7-1.60.11.0
Bone: cortical thickness0.60.71.9-0.00.0-0.1-0.11.1-1.1-1.01.4
Bone: cortical tissue density1.21.52.51.6-1.3-1.51.3-0.10.21.4-1.5
Condit. Reinf. active minus inactive responses1.92.23.9-1.81.42.0-1.4-1.61.70.4-0.9
Condit. Reinf. active-inactive response ratio1.31.43.3-1.81.21.7-1.5-0.70.7-0.40.1
Condit. Reinf. active responses2.63.26.9-2.42.12.6-1.9-1.51.5-0.4-0.4
Condit. Reinf. inactive responses1.01.22.4-1.51.51.6-1.2-0.60.5-0.90.2
Incentive salience index mean0.91.12.1-1.30.71.5-0.8-1.21.20.6-1.0
Condit. Reinf. lever presses0.10.20.5-0.2-0.60.00.3-0.10.10.6-0.7
Condit. Reinf. active minus inactive responses0.00.00.1-0.1-0.4-0.10.10.0-0.0-0.1-0.3
Condit. Reinf. active-inactive response ratio0.10.10.3-0.0-0.6-0.50.30.4-0.4-0.00.2
Condit. Reinf. active responses0.10.10.5-0.2-0.40.2-0.0-0.10.2-0.0-0.7
Condit. Reinf. inactive responses0.40.40.7-0.40.50.8-0.5-0.80.80.2-0.9
Condit. Reinf. lever presses0.81.11.71.1-1.1-1.31.01.1-1.1-0.90.4
Condit. Reinf. lever reinforcers received0.10.21.0-0.0-0.40.20.1-0.40.50.3-1.0
Conditioned reinforcement - actives0.10.10.2-0.4-0.40.1-0.10.3-0.3-0.20.1
Conditioned reinforcement - inactives0.10.10.3-0.10.3-0.1-0.10.1-0.2-0.60.5
Conditioned locomotion0.20.20.30.6-0.5-0.50.6-0.10.10.5-0.3
Patch foraging indifference point 0 sec0.00.10.20.30.50.00.30.1-0.1-0.40.2
Patch foraging indifference point AUC0.70.81.90.5-0.8-1.40.81.1-1.1-0.40.8
Delay disc. indifference point, 0s delay0.20.20.9-0.0-0.0-0.20.20.5-0.5-0.60.9
Delay disc. indifference point, 16s delay0.40.40.90.2-0.6-0.10.50.9-0.90.10.9
Delay disc. indifference point, 2s delay0.70.82.30.80.30.00.8-1.11.11.5-0.7
Delay disc. indifference point, 24s delay1.01.03.41.1-1.0-0.41.4-0.10.21.8-0.5
Delay disc. indifference point, 4s delay0.30.31.60.40.60.10.10.4-0.4-0.41.3
Delay disc. indifference point, 8s delay0.60.72.30.3-0.3-0.70.51.0-1.0-0.41.5
Indifference point function ln k0.20.30.60.20.50.7-0.2-0.80.80.5-0.6
Indifference point function log k0.20.30.60.20.50.7-0.2-0.80.80.5-0.6
Patch foraging total patch changes 0 sec0.10.10.20.40.4-0.10.40.2-0.2-0.40.1
Patch foraging total patch changes 12 sec1.41.93.61.3-1.3-1.91.71.5-1.5-0.40.8
Patch foraging total patch changes 18 sec0.10.10.30.00.2-0.50.20.2-0.2-0.5-0.1
Patch foraging total patch changes 24 sec0.60.71.61.2-0.5-1.11.30.8-0.8-0.10.1
Patch foraging total patch changes 6 sec0.10.10.3-0.10.30.10.20.3-0.3-0.50.3
Patch foraging time to switch 0 sec0.40.61.4-0.5-0.20.2-0.71.0-1.0-1.21.0
Patch foraging water rate 0 sec1.21.93.91.5-1.3-0.91.8-0.40.52.0-1.8
Patch foraging water rate 12 sec1.21.82.91.7-1.6-1.61.71.3-1.20.00.0
Patch foraging water rate 18 sec0.10.10.3-0.6-0.20.4-0.3-0.10.2-0.0-0.6
Patch foraging water rate 24 sec2.23.15.42.0-1.9-1.42.1-0.30.42.3-2.2
Patch foraging water rate 6 sec4.05.811.32.9-3.4-2.83.31.0-0.91.8-1.7
Seeking ratio, delayed vs. immediate footshock0.81.02.50.2-0.2-0.4-0.11.3-1.3-1.21.6
Distance traveled before self-admin0.50.61.5-0.20.10.1-0.6-0.91.01.0-1.2
Distance traveled after self-admin0.20.20.60.6-0.7-0.40.20.0-0.00.8-0.6
Extensor digitorum longus weight0.62.36.00.1-1.6-0.40.42.4-2.4-1.01.7
Bone: elastic displacement1.41.63.4-1.51.81.7-1.6-0.50.5-0.70.9
Bone: elastic work1.01.32.7-1.21.51.6-1.4-0.20.2-0.61.2
Bone: endosteal estimation0.20.41.0-1.0-0.30.4-0.80.4-0.4-1.00.5
Bone: endosteal perimeter0.40.82.01.0-1.4-1.01.10.4-0.40.9-0.5
Epididymis fat weight1.74.08.62.9-2.5-2.72.30.5-0.41.3-1.5
Delta time in closed arm before/after self-admin0.10.10.3-0.1-0.3-0.2-0.20.5-0.5-0.30.5
Delta time in open arm before/after self-admin0.60.51.30.2-0.1-0.70.40.8-0.8-1.01.2
Diff in mean of infusions in LGA sessions1.61.85.6-1.32.02.4-1.3-0.50.5-0.90.6
Delay discount exponential model param0.20.20.5-0.50.10.3-0.6-0.20.2-0.5-0.7
Extinction: sum of active levers before priming0.80.81.8-1.01.21.3-1.0-0.70.7-0.20.0
Active lever presses in extinction session 60.40.40.70.4-0.7-0.30.70.8-0.8-0.10.5
Bone: final force0.81.33.00.3-1.3-0.60.41.7-1.7-0.81.3
Bone: final moment0.81.22.90.3-1.1-0.40.31.7-1.7-0.81.4
Food consumed during 24 hour testing period0.20.20.60.80.3-0.30.3-0.50.50.2-0.4
Glucose0.10.20.40.3-0.5-0.40.40.6-0.6-0.30.2
Heart weight0.50.61.10.4-1.0-0.90.91.0-1.00.20.6
Delay discount hyperbolic model param0.20.20.5-0.70.10.3-0.7-0.20.2-0.5-0.7
Intermittent access intake day 1-15 change0.10.10.2-0.5-0.00.5-0.20.4-0.4-0.30.3
Intermittent access intake escalation0.10.10.3-0.60.20.5-0.20.2-0.2-0.50.4
Intermittent access intake escalation 20.20.20.9-0.60.60.9-0.4-0.30.40.0-0.2
Intermitt. access day 1 inactive lever presses3.43.67.6-1.92.82.0-2.0-0.30.2-2.41.9
Intermitt. access day 15 inactive lever presses1.11.22.8-0.11.61.0-0.2-1.71.60.5-0.7
Intermitt. access escalation Index0.80.71.3-0.61.10.8-0.7-1.11.10.4-0.5
Intermittent access day 1 total infusions0.40.40.80.9-0.3-0.40.1-0.60.60.9-0.9
Intermittent access day 15 total infusions0.30.30.60.7-0.5-0.30.4-0.20.20.8-0.7
Intermittent access terminal intake (last 3 days)0.60.61.51.0-0.8-0.40.6-0.30.41.2-1.1
Intermittent access total infusions0.40.40.90.7-0.6-0.40.3-0.40.41.0-0.9
Intermittent access day 1 locomotion0.20.20.91.0-0.3-0.80.40.0-0.00.3-0.1
Intermittent access day 15 total locomotion0.30.30.80.6-0.2-0.30.7-0.50.50.9-0.7
Intermittent access total locomotion0.10.20.50.7-0.2-0.30.4-0.20.20.5-0.4
Intermittent access standard deviation0.10.10.20.0-0.4-0.30.1-0.00.00.4-0.5
Left kidney weight2.87.813.63.7-3.7-3.73.61.8-1.81.5-0.4
Right kidney weight2.26.310.83.2-3.3-3.33.12.1-2.00.90.2
Cocaine induced anxiety0.20.20.50.10.3-0.60.1-0.70.70.1-0.4
Post-drug Anxiety0.20.20.4-0.20.3-0.1-0.3-0.70.60.2-0.5
Baseline Anxiety0.20.31.0-0.50.41.0-0.6-0.20.30.2-0.2
Tail length7.823.548.26.9-5.9-6.56.03.4-3.32.2-0.4
Length with tail10.136.977.38.8-7.2-8.17.93.5-3.43.6-1.3
Length without tail4.910.721.44.6-3.8-4.14.51.7-1.62.4-0.9
Times rat made contact with spout0.10.10.1-0.2-0.30.1-0.00.3-0.3-0.20.3
Lifetime Intake0.80.92.20.8-0.8-0.50.5-0.60.71.5-1.4
Liver weight, left0.50.82.61.6-0.7-1.11.1-0.30.30.9-0.5
Liver weight, right2.03.47.81.9-2.8-2.51.81.8-1.70.30.2
Locomotor activity3.35.311.43.4-2.8-2.33.41.4-1.31.5-0.7
Locomotor testing distance0.91.53.91.8-1.2-0.52.00.10.01.4-1.2
Locomotor testing rearing0.20.30.60.40.30.80.3-0.50.50.8-0.7
Locomotion in novel chamber0.91.13.00.8-0.10.31.0-1.01.01.7-1.5
Locomotion in novel chamber post-restriction0.10.20.5-0.10.0-0.3-0.40.4-0.4-0.40.7
Fecal boli incidents, locomotor time 12.22.44.21.0-1.6-1.71.22.1-2.0-0.81.4
Change in fecal boli incidents, locomotor task3.43.26.0-1.21.92.0-1.1-2.42.41.1-1.6
Time >=10cm from walls, locomotor time 10.10.10.3-0.30.60.3-0.1-0.50.50.1-0.3
Bouts of movement, locomotor time 10.50.61.2-0.4-0.6-0.5-0.31.1-1.1-0.90.7
Total resting periods, locomotor time 10.20.30.5-0.6-0.3-0.1-0.50.6-0.6-0.70.5
Rest time, locomotor task time 10.40.41.0-0.80.30.4-0.60.5-0.5-0.81.0
Distance moved, locomotor task time 10.20.20.40.10.20.50.1-0.60.70.4-0.7
Vertical activity count, locomotor time 11.01.01.91.4-1.0-0.41.3-0.30.41.4-1.3
Time >=10cm from walls, locomotor time 20.40.40.7-0.80.80.5-0.6-0.80.8-0.1-0.3
Bouts of movement, locomotor time 20.20.20.50.7-0.5-0.30.30.4-0.30.5-0.1
Total resting periods, locomotor time 20.20.20.40.5-0.6-0.30.30.3-0.30.5-0.2
Rest time, locomotor task time 20.30.31.5-1.2-0.00.7-0.60.2-0.2-0.20.2
Distance moved, locomotor task time 20.10.10.30.5-0.1-0.50.30.1-0.2-0.40.1
Vertical activity count, locomotor time 23.53.85.52.3-2.2-2.22.32.2-2.1-0.30.9
Light reinforcement 10.61.12.01.0-1.1-1.31.1-0.60.61.1-1.4
Light reinforcement 20.40.51.5-0.90.60.4-0.80.1-0.2-1.20.9
Bone: marrow area0.20.40.9-0.9-0.40.3-0.70.4-0.4-1.00.4
Bone: maximum diameter0.61.12.81.3-1.7-1.21.20.7-0.70.7-0.4
Bone: maximum force0.40.71.5-0.0-0.8-0.2-0.11.2-1.2-0.71.2
Bone: maximum moment0.40.61.5-0.2-0.70.1-0.21.1-1.1-0.71.2
Mean time between licks in bursts0.60.82.20.7-1.5-0.91.10.6-0.50.9-0.3
Mean num. licks in bursts0.20.30.8-0.20.70.9-0.2-0.60.60.40.1
Cd content in liver2.83.07.40.7-2.7-2.21.32.2-2.1-0.50.7
Co content in liver1.11.33.61.9-1.0-1.41.30.2-0.21.0-0.9
Cu content in liver1.92.23.61.8-1.2-1.41.41.9-1.9-1.01.1
Fe content in liver0.20.20.50.6-0.7-0.40.70.4-0.40.4-0.3
K content in liver1.11.12.70.50.1-0.00.41.2-1.2-1.61.5
Mg content in liver0.30.31.10.20.40.30.10.3-0.4-1.00.7
Mn content in liver0.20.20.50.2-0.10.50.20.7-0.7-0.70.5
Na content in liver0.30.30.70.80.2-0.40.50.3-0.4-0.80.7
Rb content in liver0.91.23.1-0.30.5-0.1-0.51.1-1.2-1.71.8
Se content in liver0.50.62.00.60.20.40.5-1.01.00.7-1.4
Sr content in liver0.30.30.80.2-0.4-0.70.30.6-0.7-0.20.9
Zn content in liver0.70.81.81.2-1.0-1.11.30.4-0.40.7-0.3
Bone: minimum diameter2.03.78.82.2-3.0-2.32.31.2-1.11.4-0.5
Time in familiar zone, hab. session 10.20.20.50.4-0.5-0.70.70.1-0.10.4-0.4
Time in novel zone, hab. session 10.80.81.7-1.20.91.0-1.3-0.10.1-0.90.9
Total zone transitions, hab. session 11.41.94.21.4-2.0-0.91.80.2-0.11.7-1.4
Total locomotion distance, hab. session 11.62.35.71.2-1.7-0.51.5-0.60.72.2-2.4
Locomotion velocity, hab. session 12.23.18.41.2-1.7-0.31.7-1.01.12.7-2.9
Time in familiar zone, hab. session 20.10.10.30.2-0.5-0.50.30.5-0.5-0.10.2
Time in novel zone, hab. session 20.30.30.6-0.70.80.7-0.7-0.50.5-0.10.1
Total zone transitions, hab. session 20.50.61.8-0.1-0.50.40.2-0.70.81.3-1.3
Total locomotion distance, hab. session 20.81.03.1-0.5-0.21.0-0.1-1.01.11.3-1.8
Locomotion velocity, hab. session 21.11.44.4-0.4-0.21.1-0.1-1.21.31.6-2.1
Novel to familiar place preference ratio0.40.51.11.00.4-0.70.7-0.80.80.4-0.5
Novelty place preference0.40.40.70.80.6-0.50.5-0.90.80.3-0.3
Time in novel zone, NPP test0.30.40.91.00.5-0.60.7-0.70.60.2-0.2
Total zone transitions, NPP test0.50.71.61.2-0.9-0.61.0-0.00.11.2-0.8
Total locomotion distance, NPP test0.70.92.90.4-0.30.50.4-0.91.01.4-1.7
Locomotion velocity, NPP test0.81.23.40.00.11.00.0-1.21.31.4-1.9
Intraocular pressure2.23.05.3-2.22.31.6-2.3-1.81.7-0.6-0.3
Delta distance traveled before/after self-admin0.60.61.40.5-0.8-0.40.61.2-1.2-0.50.8
Delta ambulatory time before/after self-admin0.50.51.10.0-0.20.10.11.0-1.0-0.91.1
Parametrial fat weight0.10.30.50.7-0.5-0.50.70.6-0.60.00.1
Pavlov. Cond. lever latency0.60.82.01.3-0.8-1.41.10.3-0.30.6-0.1
Pavlov. Cond. magazine entry latency0.40.51.4-1.2-0.10.7-0.8-0.60.70.1-0.7
Pavlov. Cond. change in total contacts0.91.02.5-1.60.71.4-1.3-0.50.5-0.7-0.3
Pavlov. Cond. index score0.30.41.3-1.20.20.9-0.8-0.40.4-0.2-0.4
Pavlov. Cond. latency score0.40.61.7-1.30.41.1-0.9-0.50.5-0.3-0.3
Pavlov. Cond. lever contacts0.10.10.3-0.50.10.6-0.2-0.10.1-0.1-0.2
Pavlov. Cond. magazine entry number0.40.50.90.90.0-0.70.80.6-0.7-0.31.0
Pavlov. Cond. intertrial magazine entries0.10.10.30.10.50.6-0.0-0.40.40.2-0.3
Pavlov. Cond. lever-magazine prob. diff.0.20.20.9-1.0-0.00.6-0.6-0.20.2-0.2-0.3
Pavlov. Cond. response bias0.30.40.8-0.90.10.9-0.6-0.60.60.1-0.8
Pavlov. Cond. lever latency0.10.20.4-0.60.10.4-0.30.4-0.4-0.00.5
Pavlov. Cond. magazine entry latency0.80.93.30.3-0.2-0.30.3-1.01.11.3-1.8
Pavlov. Cond. change in total contacts1.41.93.92.0-1.2-1.21.6-0.50.61.6-1.7
Pavlov. Cond. index score0.70.92.41.1-0.5-0.70.7-0.80.91.0-1.6
Pavlov. Cond. latency score0.60.82.30.9-0.2-0.40.5-0.90.90.9-1.5
Pavlov. Cond. lever contacts0.30.40.91.0-0.7-1.00.60.3-0.3-0.3-0.1
Pavlov. Cond. magazine entry number1.21.45.3-0.60.50.4-0.41.2-1.3-1.42.3
Pavlov. Cond. intertrial magazine entries0.40.50.80.7-0.8-0.90.80.8-0.80.10.3
Pavlov. Cond. lever-magazine prob. diff.0.70.92.31.1-0.5-0.70.7-0.80.81.0-1.5
Pavlov. Cond. response bias0.50.61.51.1-1.0-1.20.90.1-0.00.3-0.7
Time in closed arm before self-admin0.40.51.20.2-0.7-0.30.7-0.50.51.1-1.1
Time in closed arm after self-admin0.50.51.60.3-1.3-1.10.50.8-0.80.00.2
Time in open arm before self-admin0.91.02.1-0.71.31.5-0.8-1.21.20.3-0.7
Time in open arm after self-admin0.20.20.8-0.10.90.4-0.1-0.30.2-0.40.3
Bone: periosteal estimation0.20.51.70.4-1.3-0.60.40.8-0.80.10.2
Bone: periosteal perimeter0.50.91.91.1-1.4-0.91.10.8-0.70.7-0.1
Bone: post-yield work0.20.30.8-0.60.10.1-0.70.1-0.2-0.90.7
Progressive ratio test 1 active lever presses1.01.02.71.7-1.2-1.31.00.6-0.60.5-0.2
Progressive ratio test 1 breakpoint1.01.02.31.5-1.4-1.31.00.6-0.60.6-0.3
Progressive ratio test 1 inactive lever presses0.10.20.5-0.10.70.5-0.4-0.30.3-0.30.3
Progressive ratio test 2 active lever presses0.30.40.90.6-0.7-0.30.4-0.20.30.9-0.9
Progressive ratio test 2 breakpoint0.30.30.60.6-0.8-0.40.4-0.10.10.8-0.7
Progressive ratio test 2 inactive lever presses0.10.20.3-0.20.40.5-0.2-0.50.50.2-0.3
Incentive Sensitization - Responses0.10.10.30.3-0.3-0.00.4-0.10.10.6-0.5
Incentive Sensitization - Breakpoint0.10.10.20.3-0.3-0.00.4-0.10.10.5-0.4
Sum of active levers in priming session hrs 5-60.40.41.00.1-1.0-0.80.50.7-0.7-0.20.3
Progressive ratio3.03.55.8-1.62.02.1-1.4-2.42.41.1-1.6
Food seeking constrained by brief footshock0.20.30.60.8-0.5-0.40.70.6-0.6-0.00.1
Seeking ratio, punishment vs. effort1.82.23.91.5-1.4-1.41.22.0-2.0-0.91.2
Retroperitoneal fat weight1.96.213.23.6-2.9-2.63.30.3-0.22.6-2.0
Reaction time number correct0.10.20.50.4-0.1-0.10.7-0.30.30.6-0.5
Reaction time mean minus median0.40.51.2-1.01.01.1-0.8-0.50.5-0.10.2
Reaction time mean minus median AUC0.70.91.8-1.31.11.3-1.1-0.70.7-0.10.1
Reaction time num false alarms1.01.42.9-0.91.51.1-1.00.4-0.4-1.71.6
Reaction time num false alarms AUC1.31.73.3-1.11.81.4-1.20.2-0.3-1.81.7
Reaction time trials correct on left0.10.20.50.4-0.1-0.10.7-0.30.30.6-0.5
Reaction time trials on left0.10.20.40.3-0.0-0.00.6-0.30.30.6-0.4
Reaction time mean0.30.41.1-0.90.41.0-1.0-0.30.3-0.1-0.1
Reaction time mean AUC0.20.31.0-0.80.40.8-1.0-0.10.1-0.30.2
Median of all reaction times0.10.20.7-0.6-0.00.6-0.80.0-0.0-0.1-0.1
Reaction time omissions2.02.75.4-2.12.12.3-2.2-1.01.0-0.70.3
Reaction time false alarm rate1.42.03.8-1.41.71.5-1.60.3-0.3-2.01.7
Reaction time premature initiation rate0.20.31.0-0.5-1.0-0.00.10.2-0.10.5-0.9
Reaction time premature initiations0.30.41.2-0.1-0.9-0.20.50.00.10.8-1.1
Std. dev. reaction times0.70.92.1-1.41.11.5-1.3-0.40.4-0.30.4
Reaction time trials completed0.10.20.40.3-0.0-0.00.6-0.30.30.6-0.4
Reaction time trials AUC0.10.20.50.4-0.3-0.20.7-0.10.10.6-0.4
Run reversals in cocaine runway, females0.60.52.40.2-1.6-0.60.30.7-0.60.5-0.6
Run reversals in cocaine runway, males1.11.02.20.21.50.6-0.2-1.51.40.3-1.2
Latency to leave start box in cocaine runway0.60.71.31.1-0.8-0.91.1-0.10.10.8-0.9
Latency to leave start box in cocaine runway, F0.60.61.40.00.70.5-0.2-1.21.20.5-1.1
Latency to leave start box in cocaine runway, M3.73.56.32.2-2.5-2.52.31.6-1.60.90.1
Std. dev. time between licks in bursts0.20.20.70.1-0.2-0.00.3-0.40.40.8-0.8
Total sessions with >9 infusions0.70.71.41.0-0.9-0.80.6-0.30.41.2-1.1
Short access day 1 total inactive lever presses1.01.12.3-1.21.41.2-1.5-0.40.3-0.90.7
Short access day 10 total inactive lever presses0.60.72.1-0.41.51.1-0.5-1.00.90.1-0.1
Short access day 1 total infusions0.50.61.50.5-1.2-0.50.2-0.00.11.2-1.1
Short access day 10 total infusions1.21.33.51.9-1.3-1.51.40.3-0.30.9-0.5
Short access total infusions1.31.43.11.3-1.8-1.31.10.1-0.01.5-1.3
Short access day 1 locomotion0.60.71.51.2-1.1-0.80.80.7-0.70.3-0.1
Short access day 10 total locomotion0.50.60.9-0.90.60.8-0.80.5-0.5-0.90.9
Short access total locomotion0.40.40.90.4-0.5-0.50.30.9-0.9-0.50.7
One hour access (0.3 mA shock)1.61.95.20.3-0.50.20.6-1.41.52.2-2.3
Compulsive drug intake0.50.51.30.10.10.30.5-0.90.91.1-1.0
One hour access (shock baseline)0.40.51.30.3-0.20.10.1-0.80.81.1-1.1
Social response proportion4.24.69.52.2-3.1-2.42.32.3-2.30.40.6
Social responses1.92.55.52.0-2.1-1.12.30.7-0.61.7-0.8
Social time0.71.02.4-0.2-0.70.0-0.11.5-1.5-1.01.3
Soleus weight0.51.52.90.5-1.7-1.30.71.7-1.7-0.30.7
Bone: stiffness2.33.67.21.2-2.5-1.51.22.7-2.6-1.01.4
Tibialis anterior weight0.62.03.8-1.2-0.60.7-1.01.9-1.9-1.21.9
Time to tail flick, vehicle, before self-admin1.01.02.70.9-1.3-1.61.1-0.00.01.0-0.8
Time to tail flick, vehicle, after self-admin1.71.84.3-1.50.20.3-1.21.2-1.2-2.11.8
Time to tail flick, test, before self-admin0.30.30.70.8-0.5-0.50.70.3-0.30.4-0.3
Time to tail flick, test, after self-admin0.20.20.60.1-0.6-0.30.3-0.30.30.7-0.8
Delta time to tail flick, vehicle, before/after SA2.02.04.8-1.30.90.9-1.51.0-1.0-2.21.9
Delta time to tail flick, test, before/after SA0.10.10.2-0.3-0.1-0.10.0-0.40.40.3-0.3
Tibia length5.615.928.15.3-5.2-5.05.01.4-1.33.7-2.2
Ambulatory time before self-admin0.20.20.4-0.1-0.0-0.0-0.7-0.40.40.5-0.6
Ambulatory time after self-admin0.50.61.51.0-0.9-0.60.5-0.00.11.2-0.9
Bone: tissue strength0.70.71.40.3-0.5-0.10.11.2-1.1-1.01.1
Total heroin consumption0.50.51.10.50.40.30.4-0.90.91.1-0.8
Bone: trabecular number0.30.41.2-1.10.20.2-0.90.4-0.4-0.80.8
Bone: trabecular spacing0.81.12.30.20.80.50.2-1.51.51.4-1.2
Bone: trabecular thickness1.61.93.21.1-1.8-1.71.11.7-1.7-0.60.8
Bone: trabecular tissue density0.10.20.70.4-0.10.20.4-0.40.40.3-0.8
Water consumed over 24 hours0.70.81.60.3-0.5-0.90.11.2-1.2-1.31.1
Number of responses in last shaping day0.20.20.50.20.30.2-0.0-0.70.70.6-0.6