Hub : Genes

LOC102553539

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	gene expression	LOC102553539	0.13	0.06	1.9e-13	0.07	0.08	0.07	0.08	1.2e-08	3.9e-09	1.7e-08	4.0e-09
2	Liver	intron excision ratio	chr7_29886183_29886888	0.18	0.07	1.2e-15	0.06	0.12	0.11	0.1	1.8e-07	9.1e-13	2.1e-12	6.3e-11
3	Liver	intron excision ratio	chr7_29886183_29886562	0.14	0.05	7.2e-16	0.12	0.11	0.1	0.1	4.3e-13	4.9e-12	1.3e-11	1.6e-11
4	Liver	mRNA stability	LOC102553539	0.13	0.05	0.0e+00	0.11	0.14	0.13	0.13	1.3e-12	4.0e-15	7.2e-14	1.7e-14
5	Liver	intron excision ratio	chr7_29887047_29891541	0.13	0.05	0.0e+00	0.09	0.17	0.18	0.18	1.1e-09	2.4e-18	7.0e-20	9.4e-20
6	Liver	intron excision ratio	chr7_29886183_29891541	0.23	0.07	0.0e+00	0.22	0.29	0.29	0.31	2.8e-24	3.2e-32	2.7e-32	1.3e-34
7	Liver	isoform ratio	XR_593386.4	0.15	0.05	0.0e+00	0.13	0.2	0.16	0.19	2.5e-14	2.2e-21	3.6e-17	2.5e-20

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.5	0.9	1.5	-0.7	-1.0	0.3	0.7	-1.0	1.2	-1.2
Area under the delay curve	0.2	0.2	0.7	-0.1	-0.2	0.6	0.3	0.4	0.8	-0.6
BMI with tail	2.0	6.9	16.4	-4.1	-3.9	3.4	-1.8	0.9	0.3	-0.8
BMI without tail	4.4	13.4	32.1	-5.7	-5.6	4.7	-1.2	0.5	1.3	-2.2
Body weight	8.8	38.5	90.7	-9.5	-8.9	8.4	-4.3	2.9	-0.1	-1.4
Weight adjusted by age	1.1	1.6	2.6	-0.9	-1.0	0.8	-1.6	1.4	-1.6	1.2
Bone surface	0.2	0.4	0.8	-0.9	-0.7	0.6	0.1	-0.2	0.7	-0.7
Bone volume	0.6	1.0	2.0	-1.4	-1.3	1.0	0.1	-0.4	0.9	-1.0
Breakpoint value in progressive ratio session	0.3	0.4	1.2	0.6	1.1	-0.8	0.1	0.1	-0.2	0.5
Number of licking bursts	0.1	0.2	0.6	-0.1	-0.4	-0.2	0.2	-0.8	0.2	-0.4
Context. condit. distance diff. score	1.2	1.4	2.3	-0.8	-0.6	0.8	-1.5	1.5	-1.5	1.3
Locomotion velocity, session 1	0.5	0.5	1.5	1.0	1.2	-0.5	-0.1	0.3	-0.6	0.7
Locomotion distance, session 1	0.3	0.4	0.8	0.4	0.6	0.2	-0.8	0.7	-0.7	0.9
Locomotion velocity, session 2	0.2	0.3	0.6	-0.4	-0.8	0.2	0.3	-0.5	0.5	-0.8
Locomotion distance, session 2	0.2	0.3	0.7	-0.4	-0.7	0.8	-0.8	0.3	-0.0	-0.1
Locomotion velocity, session 3	1.0	1.1	2.1	-0.7	-0.2	1.0	-1.5	1.3	-1.0	1.1
Locomotion distance, session 3	1.0	1.1	2.1	-1.0	-0.9	1.1	-1.4	1.2	-0.8	0.8
Stereotopy head waving bouts, day 3	1.4	1.7	2.9	1.6	1.5	-1.7	1.2	-1.3	0.9	-0.5
Stereotopy head waving duration, day 3	0.6	0.7	1.3	0.9	1.1	-0.9	0.9	-0.8	0.6	-0.4
Locomotion velocity, session 7	1.2	1.3	2.8	-1.1	-0.8	1.7	-1.4	1.0	-1.1	0.8
Locomotion distance, session 7	0.4	0.5	0.8	-0.4	-0.3	0.8	-0.9	0.8	-0.8	0.6
Stereotopy head waving bouts, day 7	0.3	0.3	0.6	-0.3	-0.4	-0.2	0.8	-0.7	0.4	-0.8
Stereotopy head waving duration, day 7	0.4	0.4	0.9	-0.4	-0.4	-0.2	0.9	-0.8	0.7	-1.0
Locomotion velocity, session 8	0.8	1.0	1.7	-1.0	-1.3	1.0	-1.1	1.1	-0.8	0.4
Locomotion distance, session 8	3.3	4.9	8.8	-1.8	-1.7	2.3	-3.0	2.5	-2.1	1.6
Degree of sensitization distance	0.3	0.3	0.6	0.5	0.4	-0.4	0.8	-0.6	0.4	-0.4
Degree of sensitization stereotypy	0.4	0.4	0.8	-0.4	-0.5	-0.2	0.9	-0.8	0.4	-0.9
Conditioned locomotion	0.0	0.0	0.1	-0.3	0.2	0.2	0.1	-0.3	0.0	-0.0
Cocaine response after cond. corrected	1.1	1.3	2.8	-0.4	-1.1	0.1	1.2	-0.9	1.6	-1.7
Cocaine response after cond. not corrected	0.4	0.5	1.3	-0.2	-0.7	-0.1	0.7	-0.3	1.1	-1.0
Cocaine response before conditioning	1.3	1.5	3.1	0.9	1.5	-0.6	-1.1	1.3	-1.2	1.8
Saline control response	0.1	0.2	0.7	-0.5	-0.3	0.9	-0.1	-0.1	0.3	-0.3
Bone: connectivity density	0.5	0.8	1.6	0.1	-0.5	-0.4	1.3	-1.1	1.1	-1.2
Bone: cortical apparent density	1.2	1.7	2.8	-0.9	-0.9	0.9	-1.6	1.4	-1.7	1.4
Bone: cortical area	0.7	1.1	3.5	-1.9	-1.3	1.3	-0.7	0.6	0.3	-0.2
Bone: cortical porosity	1.2	1.3	3.0	-1.0	-0.5	0.6	1.1	-0.9	1.5	-1.7
Bone: cortical porosity	0.8	0.9	2.0	-0.8	-0.2	0.5	0.9	-0.8	1.4	-1.4
Bone: cortical thickness	0.5	0.8	2.7	-1.6	-1.0	1.1	-0.3	0.3	0.6	-0.4
Bone: cortical thickness	0.6	0.8	1.6	-0.4	-0.3	-0.4	1.1	-0.9	1.3	-1.1
Bone: cortical tissue density	1.4	1.9	3.1	-1.0	-0.9	1.0	-1.7	1.5	-1.8	1.4
Condit. Reinf. active minus inactive responses	1.6	1.8	4.7	1.9	2.2	-1.4	-0.2	0.3	-0.9	1.3
Condit. Reinf. active-inactive response ratio	1.1	1.2	3.4	1.6	1.8	-1.3	0.5	-0.5	0.1	0.4
Condit. Reinf. active responses	2.2	2.8	7.4	2.4	2.7	-2.2	0.7	-0.5	-0.3	0.6
Condit. Reinf. inactive responses	1.1	1.4	2.7	1.5	1.5	-1.6	1.1	-0.9	0.2	-0.3
Incentive salience index mean	0.9	1.1	2.4	1.4	1.6	-0.9	-0.6	0.5	-0.9	1.2
Condit. Reinf. lever presses	0.2	0.3	0.9	0.1	0.0	0.1	-0.9	0.6	-0.7	0.6
Condit. Reinf. active minus inactive responses	0.0	0.1	0.2	-0.3	-0.2	0.4	-0.1	-0.0	-0.2	0.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	-0.5	-0.6	0.7	0.0	-0.1	0.3	-0.4
Condit. Reinf. active responses	0.1	0.2	0.4	-0.1	0.1	0.4	-0.5	0.1	-0.5	0.6
Condit. Reinf. inactive responses	0.4	0.5	1.1	0.6	0.8	-0.4	-0.4	0.4	-0.8	1.1
Condit. Reinf. lever presses	0.6	0.8	1.9	-1.4	-1.3	1.1	0.1	-0.6	0.4	-0.7
Condit. Reinf. lever reinforcers received	0.3	0.4	0.8	-0.2	-0.0	0.6	-0.8	0.5	-0.9	0.9
Conditioned reinforcement - actives	0.0	0.1	0.2	0.5	0.4	-0.1	0.1	-0.2	0.1	-0.1
Conditioned reinforcement - inactives	0.3	0.5	1.1	0.8	0.4	-0.5	1.0	-0.7	0.5	-0.6
Conditioned locomotion	0.1	0.1	0.2	0.1	0.0	0.3	-0.4	0.4	-0.4	0.4
Patch foraging indifference point 0 sec	0.1	0.1	0.5	-0.2	-0.0	0.3	0.7	-0.3	0.3	-0.5
Patch foraging indifference point AUC	0.3	0.5	1.3	-0.8	-1.1	0.6	0.4	-0.1	0.4	-0.9
Delay disc. indifference point, 0s delay	0.2	0.3	0.6	0.1	-0.1	0.3	0.6	-0.4	0.7	-0.8
Delay disc. indifference point, 16s delay	0.2	0.2	0.8	-0.3	-0.2	0.5	-0.0	0.2	0.9	-0.6
Delay disc. indifference point, 2s delay	0.9	1.0	2.3	-0.2	0.1	1.1	-1.1	1.5	-0.9	1.1
Delay disc. indifference point, 24s delay	1.4	1.6	3.8	-0.9	-0.6	1.7	-1.5	2.0	-0.5	0.7
Delay disc. indifference point, 4s delay	0.3	0.4	1.1	0.2	0.2	0.2	0.8	-0.3	1.1	-0.7
Delay disc. indifference point, 8s delay	0.8	1.0	2.4	-0.5	-0.9	0.6	0.9	-0.3	1.5	-1.4
Indifference point function ln k	0.2	0.3	0.8	0.3	0.6	0.2	-0.6	0.4	-0.5	0.9
Indifference point function log k	0.2	0.3	0.8	0.3	0.6	0.2	-0.6	0.4	-0.5	0.9
Patch foraging total patch changes 0 sec	0.1	0.2	0.4	-0.3	-0.2	0.5	0.7	-0.3	0.2	-0.5
Patch foraging total patch changes 12 sec	1.3	1.6	3.7	-1.8	-1.9	1.4	0.5	-0.2	0.7	-1.4
Patch foraging total patch changes 18 sec	0.2	0.3	0.6	-0.3	-0.7	0.2	0.8	-0.3	0.0	-0.8
Patch foraging total patch changes 24 sec	0.4	0.7	1.5	-1.2	-1.2	0.9	0.4	0.0	0.2	-1.0
Patch foraging total patch changes 6 sec	0.2	0.2	0.7	-0.0	0.0	0.2	0.8	-0.5	0.4	-0.7
Patch foraging time to switch 0 sec	0.3	0.5	1.5	0.1	0.3	-0.5	0.7	-1.2	1.1	-0.6
Patch foraging water rate 0 sec	1.3	2.7	4.1	-1.1	-1.0	2.0	-2.0	2.0	-1.8	1.2
Patch foraging water rate 12 sec	0.7	1.5	3.4	-1.7	-1.9	1.7	-0.5	0.1	0.2	-0.8
Patch foraging water rate 18 sec	0.0	0.1	0.2	0.3	0.2	-0.0	-0.4	-0.1	-0.3	0.2
Patch foraging water rate 24 sec	3.1	4.3	7.4	-1.6	-1.5	2.2	-2.7	2.4	-2.1	1.7
Patch foraging water rate 6 sec	4.1	5.9	9.6	-3.0	-2.9	3.1	-2.9	1.8	-1.5	0.8
Seeking ratio, delayed vs. immediate footshock	1.1	1.3	3.0	-0.3	-0.5	0.4	1.2	-1.2	1.7	-1.7
Distance traveled before self-admin	0.7	0.9	1.8	-0.4	-0.5	0.1	-1.3	1.1	-1.2	1.3
Distance traveled after self-admin	0.2	0.2	0.7	-0.1	-0.1	-0.1	-0.8	0.6	-0.5	0.6
Extensor digitorum longus weight	0.3	1.3	2.6	-1.2	-0.7	0.8	0.7	-1.0	1.6	-1.5
Bone: elastic displacement	1.5	1.7	3.1	1.6	1.8	-1.7	1.4	-0.8	0.8	-0.3
Bone: elastic work	0.9	1.2	2.0	1.1	1.4	-1.1	1.3	-0.8	1.1	-0.5
Bone: endosteal estimation	0.1	0.1	0.6	0.2	-0.1	-0.2	0.1	-0.8	0.5	-0.3
Bone: endosteal perimeter	0.5	1.0	1.6	-1.2	-1.1	1.1	-1.3	0.9	-0.4	0.4
Epididymis fat weight	1.6	5.4	8.0	-2.6	-2.4	2.8	-2.8	2.2	-1.8	1.4
Delta time in closed arm before/after self-admin	0.0	0.0	0.1	0.3	0.2	-0.4	-0.2	-0.1	0.1	0.1
Delta time in open arm before/after self-admin	1.2	1.2	2.5	-0.1	-0.7	-0.0	1.6	-1.1	1.3	-1.6
Diff in mean of infusions in LGA sessions	0.4	0.5	1.5	0.4	1.2	-0.2	0.8	-0.7	0.7	-0.5
Delay discount exponential model param	0.2	0.3	0.6	0.3	0.3	-0.8	-0.1	-0.5	-0.8	0.5
Extinction: sum of active levers before priming	0.2	0.2	0.3	0.5	0.5	-0.4	0.4	-0.4	0.4	-0.3
Active lever presses in extinction session 6	0.4	0.4	1.1	-0.9	-0.5	1.0	-0.6	0.5	0.0	-0.1
Bone: final force	0.3	0.5	1.2	-0.8	-0.4	0.1	0.4	-0.7	1.1	-0.9
Bone: final moment	0.3	0.5	1.4	-0.8	-0.3	0.1	0.4	-0.7	1.2	-0.9
Food consumed during 24 hour testing period	0.1	0.2	0.7	-0.2	-0.5	0.8	-0.3	0.3	-0.4	0.2
Glucose	0.0	0.1	0.1	0.2	0.3	-0.3	0.2	-0.3	0.1	-0.3
Heart weight	1.5	2.3	5.1	-2.3	-2.0	2.2	-1.0	1.0	-0.1	-0.4
Delay discount hyperbolic model param	0.3	0.3	0.8	0.3	0.4	-0.9	0.1	-0.7	-0.6	0.3
Intermittent access intake day 1-15 change	0.2	0.4	0.9	0.1	0.5	0.0	-0.9	0.7	-0.6	0.9
Intermittent access intake escalation	0.2	0.4	0.9	0.1	0.6	0.1	-0.9	0.7	-0.6	0.9
Intermittent access intake escalation 2	0.6	0.7	1.3	-0.1	0.5	0.3	-1.1	1.0	-0.8	1.1
Intermitt. access day 1 inactive lever presses	1.5	5.8	10.9	2.5	2.1	-2.5	3.3	-2.6	1.9	-1.8
Intermitt. access day 15 inactive lever presses	0.2	0.4	0.8	0.9	0.9	-0.4	0.0	0.3	-0.8	0.7
Intermitt. access escalation Index	0.1	0.2	0.4	0.2	0.0	-0.3	-0.4	0.5	-0.7	0.6
Intermittent access day 1 total infusions	0.0	0.1	0.2	0.2	-0.4	0.2	-0.4	0.2	-0.3	0.2
Intermittent access day 15 total infusions	0.3	0.5	1.2	0.0	-0.1	0.4	-1.1	0.8	-0.8	0.9
Intermittent access terminal intake (last 3 days)	0.6	0.8	2.0	0.1	-0.1	0.5	-1.4	1.0	-1.0	1.1
Intermittent access total infusions	0.3	0.4	0.9	0.5	0.0	0.2	-1.0	0.6	-0.7	0.7
Intermittent access day 1 locomotion	0.2	0.3	0.6	-0.1	-0.8	0.2	0.5	-0.5	0.6	-0.8
Intermittent access day 15 total locomotion	0.2	0.4	0.8	0.5	0.3	0.1	-0.5	0.8	-0.9	0.8
Intermittent access total locomotion	0.0	0.0	0.1	0.2	-0.1	0.2	-0.2	0.2	-0.2	0.0
Intermittent access standard deviation	0.1	0.3	0.9	1.0	0.4	-0.6	-0.3	-0.0	-0.3	0.4
Left kidney weight	3.1	14.5	31.9	-5.6	-4.6	4.7	-3.8	3.1	-1.5	0.7
Right kidney weight	2.4	10.8	24.9	-5.0	-4.0	4.3	-3.1	2.3	-1.1	0.3
Cocaine induced anxiety	0.0	0.1	0.2	0.3	-0.1	-0.2	-0.0	0.1	-0.5	0.3
Post-drug Anxiety	0.3	0.3	0.8	0.2	0.1	-0.2	-0.6	0.5	-0.9	0.9
Baseline Anxiety	0.3	0.4	0.7	-0.3	0.3	0.4	-0.8	0.7	-0.6	0.8
Tail length	7.0	27.3	61.7	-7.9	-7.5	7.2	-3.2	2.9	-0.5	-1.0
Length with tail	8.4	36.7	82.7	-9.1	-8.3	8.3	-4.6	3.7	-1.2	-0.4
Length without tail	4.5	14.5	29.5	-5.4	-4.8	5.1	-3.6	2.8	-1.4	0.5
Times rat made contact with spout	0.0	0.0	0.1	0.1	-0.1	0.2	-0.0	-0.1	0.3	-0.2
Lifetime Intake	0.4	0.5	1.5	0.1	-0.4	0.5	-1.2	0.8	-0.8	0.8
Liver weight, left	1.5	2.5	6.8	-2.6	-2.1	1.9	-0.6	0.2	0.9	-1.0
Liver weight, right	2.2	3.9	9.9	-3.1	-3.0	2.4	-1.1	0.3	0.8	-1.0
Locomotor activity	3.3	5.2	12.6	-3.6	-2.3	3.4	-2.0	1.6	-0.7	0.2
Locomotor testing distance	1.3	2.4	4.8	-2.0	-0.8	2.2	-1.8	1.5	-1.2	0.8
Locomotor testing rearing	0.2	0.4	0.7	-0.4	0.7	0.4	-0.6	0.8	-0.7	0.8
Locomotion in novel chamber	1.6	2.1	4.0	-0.4	0.1	1.3	-1.8	2.0	-1.7	1.5
Locomotion in novel chamber post-restriction	0.2	0.3	0.5	-0.1	-0.6	0.3	0.4	-0.5	0.7	-0.7
Fecal boli incidents, locomotor time 1	1.3	1.8	3.5	-1.5	-1.9	0.6	0.7	-1.0	1.5	-1.8
Change in fecal boli incidents, locomotor task	2.5	2.5	5.5	2.0	2.4	-1.0	-0.5	0.9	-1.5	1.8
Time >=10cm from walls, locomotor time 1	0.1	0.1	0.2	0.2	0.5	-0.4	0.2	-0.0	-0.4	0.3
Bouts of movement, locomotor time 1	0.5	0.5	1.0	-0.1	-0.6	-0.4	0.7	-1.0	0.9	-1.0
Total resting periods, locomotor time 1	0.3	0.3	0.6	0.2	-0.1	-0.6	0.6	-0.8	0.6	-0.6
Rest time, locomotor task time 1	0.3	0.4	0.7	0.6	0.4	-0.8	0.8	-0.5	0.7	-0.5
Distance moved, locomotor task time 1	0.3	0.5	0.9	0.0	0.4	0.6	-0.9	0.6	-0.9	1.0
Vertical activity count, locomotor time 1	1.0	2.3	4.8	-1.1	-0.4	1.6	-2.2	1.6	-1.6	1.5
Time >=10cm from walls, locomotor time 2	0.1	0.2	0.6	0.8	0.6	-0.5	0.3	-0.0	-0.5	0.3
Bouts of movement, locomotor time 2	0.1	0.2	0.4	-0.5	-0.1	0.6	-0.4	0.5	-0.2	0.3
Total resting periods, locomotor time 2	0.1	0.2	0.3	-0.4	-0.1	0.5	-0.4	0.6	-0.3	0.4
Rest time, locomotor task time 2	0.3	0.4	1.2	0.6	0.8	-1.1	0.4	-0.3	0.3	-0.0
Distance moved, locomotor task time 2	0.2	0.2	0.5	-0.5	-0.7	0.6	-0.0	-0.2	0.1	-0.4
Vertical activity count, locomotor time 2	1.8	2.4	5.9	-2.4	-2.2	2.0	-0.5	-0.2	0.7	-1.2
Light reinforcement 1	0.7	1.7	2.5	-1.2	-1.3	1.2	-1.6	1.4	-1.4	1.1
Light reinforcement 2	0.4	0.6	1.2	0.4	0.2	-0.8	1.1	-1.0	0.8	-0.8
Bone: marrow area	0.1	0.1	0.6	0.2	-0.1	-0.2	0.1	-0.7	0.5	-0.3
Bone: maximum diameter	0.7	1.4	2.8	-1.7	-1.3	1.4	-1.4	0.9	-0.5	0.4
Bone: maximum force	0.2	0.3	0.8	-0.7	-0.2	0.4	0.3	-0.5	0.9	-0.5
Bone: maximum moment	0.2	0.3	1.0	-0.6	-0.1	0.4	0.3	-0.5	1.0	-0.6
Mean time between licks in bursts	0.1	0.3	0.8	-0.3	-0.1	0.1	-0.9	0.9	-0.4	0.6
Mean num. licks in bursts	0.2	0.3	1.1	0.9	1.0	-0.2	0.1	0.5	-0.1	0.3
Cd content in liver	0.7	0.8	1.8	-0.7	-1.3	0.1	0.4	-0.9	0.9	-1.2
Co content in liver	1.0	1.2	2.5	0.5	0.6	0.3	-1.2	1.3	-1.5	1.6
Cu content in liver	1.4	1.7	3.4	-1.2	-1.0	0.5	1.2	-1.4	1.6	-1.8
Fe content in liver	0.3	0.3	1.1	-0.8	-0.5	1.0	-0.2	-0.0	0.4	-0.5
K content in liver	1.4	1.4	2.7	-0.6	-0.3	0.0	1.2	-1.6	1.6	-1.5
Mg content in liver	0.4	0.4	0.7	0.3	0.7	-0.5	0.8	-0.8	0.8	-0.5
Mn content in liver	0.0	0.0	0.2	-0.3	0.4	-0.0	-0.2	-0.1	-0.1	0.2
Na content in liver	0.6	0.6	0.8	-0.9	-0.6	0.8	0.7	-0.6	0.8	-0.9
Rb content in liver	1.6	1.8	3.5	0.5	0.0	-1.0	1.9	-1.5	1.7	-1.7
Se content in liver	0.2	0.2	0.5	-0.1	0.5	-0.1	-0.5	0.2	-0.7	0.6
Sr content in liver	0.2	0.2	0.8	-0.0	-0.2	0.9	0.2	-0.1	0.4	-0.3
Zn content in liver	2.0	2.2	4.6	-1.8	-2.1	1.7	-1.6	1.1	-0.8	0.4
Bone: minimum diameter	2.3	4.2	8.2	-2.9	-2.5	2.6	-2.2	1.6	-0.7	0.5
Time in familiar zone, hab. session 1	0.2	0.2	0.6	-0.5	-0.8	0.2	-0.2	0.4	-0.5	-0.1
Time in novel zone, hab. session 1	0.8	0.8	1.2	1.0	1.0	-0.8	0.9	-1.1	0.9	-0.3
Total zone transitions, hab. session 1	2.2	3.0	5.9	-1.4	-0.8	2.2	-2.4	1.9	-1.6	1.4
Total locomotion distance, hab. session 1	2.9	4.1	8.1	-1.1	-0.3	2.0	-2.8	2.4	-2.4	2.1
Locomotion velocity, hab. session 1	4.1	5.8	11.3	-1.1	-0.1	2.2	-3.4	2.9	-2.9	2.6
Time in familiar zone, hab. session 2	0.1	0.1	0.3	-0.6	-0.6	0.3	0.0	0.0	0.1	-0.4
Time in novel zone, hab. session 2	0.3	0.3	0.7	0.8	0.7	-0.6	0.4	-0.3	0.2	0.2
Total zone transitions, hab. session 2	1.2	1.6	3.2	0.2	0.6	0.4	-1.8	1.5	-1.5	1.7
Total locomotion distance, hab. session 2	1.5	1.9	3.5	0.6	1.2	0.1	-1.7	1.4	-1.8	1.9
Locomotion velocity, hab. session 2	1.9	2.6	4.8	0.6	1.2	0.1	-2.0	1.7	-2.1	2.2
Novel to familiar place preference ratio	0.2	0.2	0.7	-0.4	-0.6	0.9	-0.0	0.5	-0.5	0.1
Novelty place preference	0.1	0.2	0.5	-0.2	-0.5	0.7	0.2	0.4	-0.4	0.0
Time in novel zone, NPP test	0.2	0.2	0.6	-0.4	-0.6	0.8	0.2	0.3	-0.2	-0.1
Total zone transitions, NPP test	0.9	1.3	2.1	-0.9	-0.4	1.5	-1.4	1.3	-1.0	1.0
Total locomotion distance, NPP test	1.3	1.7	3.1	-0.1	0.7	0.8	-1.8	1.5	-1.7	1.7
Locomotion velocity, NPP test	1.4	1.9	3.4	0.4	1.1	0.4	-1.7	1.5	-1.8	1.9
Intraocular pressure	1.5	2.1	6.6	2.6	1.6	-1.9	1.1	-0.6	-0.2	0.4
Delta distance traveled before/after self-admin	0.4	0.4	0.9	0.1	0.3	-0.1	0.6	-0.8	1.0	-0.9
Delta ambulatory time before/after self-admin	0.5	0.6	1.1	0.4	0.7	-0.3	0.8	-1.0	1.0	-0.9
Parametrial fat weight	0.5	1.2	3.8	-1.9	-1.5	1.2	-0.8	0.3	0.0	-0.3
Pavlov. Cond. lever latency	0.5	0.6	1.9	-1.1	-1.4	0.7	-0.3	0.5	-0.2	-0.1
Pavlov. Cond. magazine entry latency	0.5	0.7	1.5	0.8	0.9	-0.2	-0.8	0.3	-0.9	1.2
Pavlov. Cond. change in total contacts	0.7	0.8	1.9	1.3	1.4	-1.1	0.1	-0.6	-0.2	0.4
Pavlov. Cond. index score	0.3	0.3	0.9	0.9	1.0	-0.5	-0.2	-0.2	-0.3	0.5
Pavlov. Cond. latency score	0.4	0.4	1.3	1.1	1.1	-0.6	-0.1	-0.3	-0.2	0.4
Pavlov. Cond. lever contacts	0.1	0.2	0.6	0.6	0.7	-0.2	0.1	-0.4	0.2	-0.0
Pavlov. Cond. magazine entry number	0.3	0.4	0.9	-0.6	-0.6	0.3	0.8	-0.2	0.7	-1.0
Pavlov. Cond. intertrial magazine entries	0.1	0.1	0.3	0.2	0.6	-0.4	-0.1	0.2	-0.3	0.3
Pavlov. Cond. lever-magazine prob. diff.	0.2	0.2	0.5	0.7	0.7	-0.4	-0.3	-0.2	-0.2	0.4
Pavlov. Cond. response bias	0.4	0.5	1.3	1.0	1.2	-0.6	-0.2	-0.3	-0.4	0.6
Pavlov. Cond. lever latency	0.2	0.3	0.8	0.7	0.6	-0.9	0.4	-0.1	0.3	-0.3
Pavlov. Cond. magazine entry latency	1.1	1.3	3.2	0.1	-0.0	0.2	-1.4	1.3	-1.8	1.5
Pavlov. Cond. change in total contacts	1.7	2.8	4.3	-1.3	-1.2	2.1	-2.1	1.8	-1.6	1.3
Pavlov. Cond. index score	1.1	1.4	2.3	-0.7	-0.7	1.2	-1.5	1.2	-1.5	1.2
Pavlov. Cond. latency score	0.9	1.2	2.2	-0.4	-0.4	0.9	-1.4	1.2	-1.5	1.3
Pavlov. Cond. lever contacts	0.3	0.5	1.3	-0.8	-0.9	1.1	-0.6	0.1	-0.3	0.2
Pavlov. Cond. magazine entry number	1.8	2.2	4.8	0.3	0.3	-0.6	2.0	-1.6	2.2	-1.9
Pavlov. Cond. intertrial magazine entries	0.3	0.4	1.3	-1.2	-0.7	1.0	0.2	0.0	0.3	-0.4
Pavlov. Cond. lever-magazine prob. diff.	1.1	1.4	2.4	-0.6	-0.6	1.1	-1.6	1.2	-1.5	1.3
Pavlov. Cond. response bias	0.7	1.0	1.6	-1.0	-1.1	1.3	-1.2	0.7	-0.9	0.6
Time in closed arm before self-admin	0.8	1.0	1.7	-0.7	-0.5	0.6	-1.3	1.2	-1.2	1.1
Time in closed arm after self-admin	0.4	0.4	0.9	-0.9	-1.0	0.4	-0.8	0.4	-0.2	0.2
Time in open arm before self-admin	0.4	0.5	1.8	0.9	1.3	-0.5	-0.0	0.1	-0.3	0.5
Time in open arm after self-admin	0.7	0.8	2.1	0.6	0.2	-0.6	1.4	-0.9	0.9	-1.0
Bone: periosteal estimation	0.3	0.5	1.2	-1.1	-0.9	0.9	-0.9	0.3	0.0	0.2
Bone: periosteal perimeter	0.5	0.8	2.0	-1.4	-1.0	1.1	-0.9	0.8	-0.1	0.1
Bone: post-yield work	0.2	0.3	0.5	-0.2	-0.4	-0.1	0.5	-0.7	0.7	-0.6
Progressive ratio test 1 active lever presses	1.0	1.3	2.6	-1.1	-1.6	1.6	-1.3	0.8	-0.5	0.1
Progressive ratio test 1 breakpoint	1.0	1.2	2.5	-1.0	-1.6	1.6	-1.3	0.8	-0.5	0.1
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.7	0.9	0.6	-0.6	0.8	-0.6	0.2	-0.2
Progressive ratio test 2 active lever presses	0.3	0.3	0.9	-0.1	-0.3	0.5	-0.9	0.6	-0.6	0.5
Progressive ratio test 2 breakpoint	0.3	0.4	1.1	-0.0	-0.2	0.4	-1.0	0.7	-0.7	0.6
Progressive ratio test 2 inactive lever presses	0.1	0.2	0.2	0.4	0.4	0.3	-0.4	0.3	-0.5	0.4
Incentive Sensitization - Responses	0.2	0.3	0.7	-0.1	-0.0	0.2	-0.9	0.6	-0.6	0.5
Incentive Sensitization - Breakpoint	0.2	0.2	0.6	-0.1	0.0	0.1	-0.8	0.6	-0.5	0.5
Sum of active levers in priming session hrs 5-6	0.5	0.5	1.4	-0.8	-1.2	0.7	-0.1	-0.3	0.4	-0.6
Progressive ratio	1.7	2.6	4.5	1.7	2.0	-0.7	-0.8	1.5	-1.8	2.1
Food seeking constrained by brief footshock	0.1	0.1	0.3	-0.6	-0.6	0.3	-0.3	-0.1	0.1	-0.3
Seeking ratio, punishment vs. effort	1.0	1.4	2.5	-1.4	-1.5	0.6	0.4	-1.1	1.2	-1.6
Retroperitoneal fat weight	1.6	7.0	12.3	-3.5	-2.8	3.2	-2.9	2.3	-1.7	1.1
Reaction time number correct	0.1	0.3	1.1	-0.2	-0.1	1.0	-0.4	0.6	-0.5	0.3
Reaction time mean minus median	0.2	0.4	1.2	0.8	1.1	-0.8	0.5	-0.1	0.1	0.2
Reaction time mean minus median AUC	0.3	0.7	1.8	1.2	1.3	-1.1	0.4	-0.1	-0.0	0.3
Reaction time num false alarms	1.5	2.1	3.9	0.9	1.1	-1.2	2.0	-1.7	1.5	-1.4
Reaction time num false alarms AUC	1.7	2.6	4.9	1.1	1.4	-1.4	2.2	-1.8	1.6	-1.4
Reaction time trials correct on left	0.1	0.3	1.1	-0.2	-0.1	1.0	-0.4	0.6	-0.5	0.3
Reaction time trials on left	0.1	0.2	0.9	-0.1	-0.0	1.0	-0.3	0.5	-0.4	0.3
Reaction time mean	0.3	0.5	1.2	0.8	1.1	-1.0	-0.1	0.0	-0.2	0.6
Reaction time mean AUC	0.2	0.3	0.8	0.7	0.9	-0.9	0.1	-0.2	0.1	0.4
Median of all reaction times	0.2	0.3	0.8	0.7	0.8	-0.9	-0.3	-0.1	-0.2	0.6
Reaction time omissions	1.5	2.2	5.9	2.1	2.4	-1.8	1.1	-0.6	0.1	0.4
Reaction time false alarm rate	2.0	2.8	4.3	1.3	1.5	-1.9	2.1	-1.9	1.6	-1.3
Reaction time premature initiation rate	0.2	0.3	0.7	-0.3	-0.1	-0.0	-0.8	0.4	-0.8	0.7
Reaction time premature initiations	0.3	0.4	0.8	-0.5	-0.2	0.6	-0.9	0.6	-0.9	0.7
Std. dev. reaction times	0.4	0.8	2.3	1.1	1.5	-1.1	0.6	-0.3	0.3	0.3
Reaction time trials completed	0.1	0.2	0.9	-0.1	-0.0	1.0	-0.3	0.5	-0.4	0.3
Reaction time trials AUC	0.1	0.3	1.2	-0.3	-0.2	1.1	-0.4	0.5	-0.4	0.2
Run reversals in cocaine runway, females	0.7	0.7	2.0	-1.0	-0.9	0.7	-1.4	0.7	-0.4	0.5
Run reversals in cocaine runway, males	0.3	0.3	1.2	0.5	0.6	0.0	0.0	0.3	-1.1	0.5
Latency to leave start box in cocaine runway	0.5	0.6	1.6	-0.8	-0.6	1.3	-0.7	0.6	-0.6	0.3
Latency to leave start box in cocaine runway, F	0.5	0.5	1.1	0.9	1.0	-0.3	-0.2	0.1	-0.9	0.9
Latency to leave start box in cocaine runway, M	3.5	3.3	7.2	-2.7	-2.6	2.7	-0.6	0.6	0.6	-1.0
Std. dev. time between licks in bursts	0.2	0.3	0.6	-0.2	-0.1	0.4	-0.7	0.8	-0.7	0.7
Total sessions with >9 infusions	0.4	0.5	1.7	-0.7	-1.3	0.8	-0.6	0.1	0.1	-0.4
Short access day 1 total inactive lever presses	1.3	1.7	2.5	1.1	0.6	-1.4	1.6	-1.6	1.4	-1.2
Short access day 10 total inactive lever presses	0.6	1.4	3.8	1.6	2.0	-1.4	1.2	-0.4	0.0	0.1
Short access day 1 total infusions	0.2	0.3	0.9	0.3	-0.3	-0.2	-0.9	0.4	-0.5	0.7
Short access day 10 total infusions	0.7	0.9	2.6	-1.2	-1.6	1.3	-0.5	0.2	0.1	-0.5
Short access total infusions	0.6	0.8	1.8	-0.7	-1.4	0.9	-1.2	0.7	-0.6	0.4
Short access day 1 locomotion	0.4	0.5	0.9	-0.6	-0.9	0.4	0.3	-0.5	0.8	-1.0
Short access day 10 total locomotion	1.5	2.8	4.5	1.7	1.3	-1.8	2.1	-1.8	1.5	-1.4
Short access total locomotion	0.8	1.0	2.3	-0.1	-0.8	-0.1	1.1	-1.1	1.3	-1.5
One hour access (0.3 mA shock)	2.8	3.2	7.3	-0.4	-0.4	1.5	-2.7	2.1	-2.1	2.0
Compulsive drug intake	0.1	0.2	0.6	-0.2	-0.2	0.8	-0.3	0.5	-0.2	0.1
One hour access (shock baseline)	0.5	0.8	2.1	-0.2	-0.1	0.5	-1.5	1.0	-1.0	1.0
Social response proportion	2.4	2.7	6.4	-2.5	-2.5	2.0	-1.3	0.5	0.5	-0.7
Social responses	2.1	2.8	4.8	-2.1	-1.1	2.1	-2.2	1.8	-0.9	0.9
Social time	0.5	0.7	1.7	-0.3	-0.1	-0.3	0.6	-1.0	1.3	-1.2
Soleus weight	0.3	0.8	2.0	-1.4	-1.4	0.6	-0.1	-0.2	0.7	-0.9
Bone: stiffness	1.1	1.8	4.5	-2.1	-1.5	1.7	-0.2	-0.7	1.1	-1.0
Tibialis anterior weight	0.4	1.2	3.3	0.2	0.7	-0.4	1.1	-1.5	1.8	-1.2
Time to tail flick, vehicle, before self-admin	0.7	0.8	3.1	-1.0	-1.7	0.7	-0.7	0.6	-0.3	-0.0
Time to tail flick, vehicle, after self-admin	2.1	2.8	4.5	1.0	0.3	-1.9	1.9	-2.1	1.9	-1.8
Time to tail flick, test, before self-admin	0.5	0.5	1.4	-1.2	-0.9	0.9	-0.6	0.3	-0.2	-0.0
Time to tail flick, test, after self-admin	0.5	0.6	0.9	-1.0	-0.9	0.9	-0.8	0.7	-0.4	0.3
Delta time to tail flick, vehicle, before/after SA	3.2	3.0	4.8	1.3	1.0	-1.8	2.0	-2.2	1.9	-1.7
Delta time to tail flick, test, before/after SA	0.0	0.0	0.1	0.0	-0.1	0.3	-0.0	0.3	-0.2	0.1
Tibia length	6.2	17.0	25.6	-5.1	-4.9	4.8	-4.8	3.9	-2.4	1.7
Ambulatory time before self-admin	0.2	0.3	0.7	-0.6	-0.8	0.1	-0.8	0.5	-0.5	0.5
Ambulatory time after self-admin	0.7	0.8	2.1	-0.5	-0.4	0.5	-1.5	1.2	-0.9	1.0
Bone: tissue strength	0.6	0.6	1.2	-0.8	-0.2	0.6	0.6	-0.9	1.1	-0.9
Total heroin consumption	0.5	0.6	1.0	0.2	0.9	0.4	-0.6	0.9	-0.9	1.0
Bone: trabecular number	0.3	0.5	0.9	0.2	-0.1	-0.8	0.9	-0.9	0.9	-0.8
Bone: trabecular spacing	0.6	0.8	1.9	0.4	0.6	0.1	-0.7	1.4	-1.2	1.1
Bone: trabecular thickness	1.0	1.2	3.2	-1.7	-1.8	0.9	-0.0	-0.5	0.7	-1.0
Bone: trabecular tissue density	0.3	0.5	1.0	0.1	0.4	0.0	-0.9	0.5	-1.0	1.0
Water consumed over 24 hours	1.1	1.5	2.8	-1.0	-1.7	1.0	0.6	-1.0	1.3	-1.6
Number of responses in last shaping day	0.5	0.5	0.9	0.9	0.8	-0.2	-0.5	0.5	-0.8	0.9