Hub : Genes

LOC102553505

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Liver	intron excision ratio	chr20_2954360_2955331	0.05	0.04	2.1e-03	0.01	0.02	0.01	0.01	1.7e-02	1.2e-03	3.6e-02	2.8e-02
2	Liver	intron excision ratio	chr20_2953921_2955331	0.48	0.22	8.2e-07	0.04	0.06	0.05	0.04	1.1e-05	7.5e-07	1.9e-06	8.1e-06
3	Liver	intron excision ratio	chr20_2958693_2958849	0.22	0.12	7.7e-09	0.01	0.03	0.02	0.02	5.9e-02	1.2e-04	2.8e-03	2.8e-03
4	Liver	gene expression	LOC102553505	0.27	0.12	0.0e+00	0.21	0.26	0.26	0.26	6.3e-23	7.0e-29	4.5e-29	3.3e-28

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bone: apparent density	1.4	2.6	3.0	-1.6	-1.5	1.7	-1.6
Area under the delay curve	0.5	0.8	2.3	0.3	0.1	-1.0	1.5
BMI with tail	0.6	2.2	5.0	-1.2	-1.5	-0.1	2.2
BMI without tail	0.6	3.0	9.8	-0.4	-0.6	-1.3	3.1
Body weight	3.2	14.1	28.2	2.6	2.0	-4.2	5.3
Weight adjusted by age	0.8	2.5	3.5	1.5	1.1	-1.7	1.9
Bone surface	0.3	0.7	1.2	0.8	0.8	-1.1	0.3
Bone volume	0.0	0.0	0.1	-0.2	-0.2	-0.1	0.1
Breakpoint value in progressive ratio session	0.2	0.3	0.7	0.0	0.5	0.8	-0.6
Number of licking bursts	0.3	0.8	1.4	1.2	1.2	-0.7	-0.1
Context. condit. distance diff. score	2.7	3.3	9.0	1.3	1.5	0.2	-3.0
Locomotion velocity, session 1	0.2	0.3	0.4	0.6	0.6	-0.2	-0.6
Locomotion distance, session 1	1.0	1.3	1.7	-1.3	-1.2	1.3	-0.4
Locomotion velocity, session 2	0.1	0.1	0.2	0.5	0.4	-0.2	-0.1
Locomotion distance, session 2	0.3	0.4	0.9	-0.5	-0.5	0.9	-0.6
Locomotion velocity, session 3	0.4	0.5	0.8	-0.9	-0.9	0.5	0.1
Locomotion distance, session 3	0.9	1.1	2.0	-0.8	-0.6	1.1	-1.4
Stereotopy head waving bouts, day 3	2.4	2.9	3.2	1.8	1.7	-1.8	1.5
Stereotopy head waving duration, day 3	1.4	1.7	2.0	1.3	1.2	-1.3	1.4
Locomotion velocity, session 7	2.2	2.4	6.6	-0.7	-0.6	1.5	-2.6
Locomotion distance, session 7	2.4	3.1	6.1	-1.3	-1.2	1.8	-2.5
Stereotopy head waving bouts, day 7	1.7	1.9	4.4	0.9	0.8	-1.3	2.1
Stereotopy head waving duration, day 7	1.6	2.0	4.5	1.0	0.8	-1.4	2.1
Locomotion velocity, session 8	4.0	4.9	8.4	2.9	2.8	-1.8	-0.1
Locomotion distance, session 8	1.4	2.1	6.2	0.9	1.0	0.4	-2.5
Degree of sensitization distance	0.4	0.4	0.8	0.9	0.7	-0.5	-0.5
Degree of sensitization stereotypy	0.6	0.6	1.9	0.3	0.2	-0.7	1.4
Conditioned locomotion	0.7	0.8	0.9	0.9	0.9	-0.8	1.0
Cocaine response after cond. corrected	0.3	0.4	0.6	-0.5	-0.4	0.8	-0.8
Cocaine response after cond. not corrected	0.4	0.6	1.0	1.0	0.9	-0.7	0.2
Cocaine response before conditioning	5.0	6.0	8.2	2.4	2.1	-2.9	2.4
Saline control response	0.8	1.2	1.8	-1.1	-1.2	-0.0	1.4
Bone: connectivity density	1.3	2.1	4.7	-0.9	-0.7	1.5	-2.2
Bone: cortical apparent density	1.0	1.6	2.4	-1.5	-1.6	1.2	0.4
Bone: cortical area	0.8	1.2	2.7	0.7	0.5	-1.2	1.6
Bone: cortical porosity	0.3	0.4	0.9	0.2	0.1	-0.7	1.0
Bone: cortical porosity	0.8	0.9	1.5	0.9	0.7	-1.2	0.9
Bone: cortical thickness	1.6	2.6	4.6	-1.6	-1.8	0.4	2.2
Bone: cortical thickness	2.2	2.6	4.4	-1.9	-2.1	1.2	0.9
Bone: cortical tissue density	0.9	1.4	2.1	-1.4	-1.4	1.2	0.3
Condit. Reinf. active minus inactive responses	0.5	0.5	1.3	-0.3	-0.2	0.8	-1.2
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.3	-0.5	-0.6	0.6	0.1
Condit. Reinf. active responses	0.9	1.2	2.7	-0.6	-0.5	1.2	-1.7
Condit. Reinf. inactive responses	2.1	2.7	4.1	-1.5	-1.3	1.7	-2.0
Incentive salience index mean	0.8	1.0	2.7	0.7	0.8	0.3	-1.7
Condit. Reinf. lever presses	1.5	2.2	5.1	1.3	1.4	-0.0	-2.3
Condit. Reinf. active minus inactive responses	0.8	1.2	1.9	1.0	0.7	-1.4	1.2
Condit. Reinf. active-inactive response ratio	1.8	2.9	3.7	1.7	1.4	-1.9	1.8
Condit. Reinf. active responses	0.0	0.1	0.1	0.3	0.1	-0.3	-0.3
Condit. Reinf. inactive responses	1.0	1.5	3.1	-0.9	-0.8	1.1	-1.8
Condit. Reinf. lever presses	0.2	0.3	1.1	-0.1	-0.1	0.4	-1.0
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.3	0.3	-0.3	-0.4
Conditioned reinforcement - actives	0.2	0.8	2.2	-0.4	-0.2	-0.8	1.5
Conditioned reinforcement - inactives	0.3	0.8	2.2	-0.6	-0.5	-0.6	1.5
Conditioned locomotion	0.3	0.5	1.4	0.4	0.4	-1.2	0.4
Patch foraging indifference point 0 sec	0.6	1.6	2.7	-1.6	-1.4	1.0	0.9
Patch foraging indifference point AUC	0.4	1.0	2.1	0.7	0.3	-1.5	1.2
Delay disc. indifference point, 0s delay	0.7	0.8	0.9	0.8	0.9	-0.9	0.9
Delay disc. indifference point, 16s delay	1.0	1.5	2.2	-1.3	-1.5	-0.1	1.4
Delay disc. indifference point, 2s delay	1.8	2.0	4.0	1.1	1.2	-1.3	2.0
Delay disc. indifference point, 24s delay	0.2	0.3	0.6	-0.4	-0.5	-0.1	0.8
Delay disc. indifference point, 4s delay	2.1	2.3	3.5	1.3	1.3	-1.6	1.9
Delay disc. indifference point, 8s delay	0.1	0.1	0.3	-0.0	-0.1	-0.3	0.6
Indifference point function ln k	0.1	0.3	0.4	0.6	0.6	-0.1	-0.5
Indifference point function log k	0.1	0.3	0.4	0.6	0.6	-0.1	-0.5
Patch foraging total patch changes 0 sec	0.7	1.9	3.1	-1.8	-1.6	0.9	1.1
Patch foraging total patch changes 12 sec	1.1	1.5	2.3	-1.4	-1.5	0.4	1.1
Patch foraging total patch changes 18 sec	1.6	3.7	6.4	-2.5	-2.5	1.5	0.2
Patch foraging total patch changes 24 sec	1.4	4.9	7.7	-2.8	-2.6	2.1	-0.4
Patch foraging total patch changes 6 sec	1.7	2.9	4.5	-2.1	-2.1	1.2	1.0
Patch foraging time to switch 0 sec	0.4	1.6	2.3	-1.5	-1.2	1.5	-0.4
Patch foraging water rate 0 sec	0.1	0.4	1.3	0.1	-0.4	-0.5	1.1
Patch foraging water rate 12 sec	0.2	0.7	1.5	-1.0	-1.2	0.7	-0.2
Patch foraging water rate 18 sec	0.1	0.2	0.3	0.5	0.3	-0.6	0.3
Patch foraging water rate 24 sec	0.5	0.7	1.9	0.1	-0.5	-0.7	1.4
Patch foraging water rate 6 sec	0.4	0.6	1.7	-0.8	-1.3	0.3	0.0
Seeking ratio, delayed vs. immediate footshock	0.1	0.2	0.3	0.5	0.5	0.0	0.6
Distance traveled before self-admin	0.6	1.2	2.0	1.3	1.4	-1.1	0.0
Distance traveled after self-admin	1.0	1.8	2.7	1.3	1.6	-1.2	1.3
Extensor digitorum longus weight	0.3	1.1	1.6	1.1	1.2	-1.3	-0.1
Bone: elastic displacement	0.4	0.5	0.7	-0.8	-0.8	0.5	0.7
Bone: elastic work	0.8	1.1	3.8	-0.0	-0.1	-0.7	2.0
Bone: endosteal estimation	5.8	14.2	18.8	4.3	4.1	-4.2	1.7
Bone: endosteal perimeter	3.3	8.1	12.5	3.5	3.5	-2.8	-0.2
Epididymis fat weight	4.8	24.5	38.5	-6.2	-6.2	4.1	2.1
Delta time in closed arm before/after self-admin	0.2	0.2	0.6	0.0	-0.2	-0.3	0.8
Delta time in open arm before/after self-admin	0.1	0.1	0.2	0.3	0.4	-0.4	0.1
Diff in mean of infusions in LGA sessions	1.5	2.7	4.5	-1.4	-0.7	1.9	-2.1
Delay discount exponential model param	0.6	0.9	2.4	-0.3	-0.1	1.0	-1.5
Extinction: sum of active levers before priming	0.1	0.2	0.5	-0.1	0.3	0.7	-0.4
Active lever presses in extinction session 6	0.8	0.8	1.3	-1.2	-0.9	0.9	-0.2
Bone: final force	1.9	3.1	10.4	-0.1	-0.4	-1.3	3.2
Bone: final moment	1.7	2.7	8.8	0.0	-0.3	-1.3	3.0
Food consumed during 24 hour testing period	0.7	1.4	2.0	1.4	1.2	-1.3	0.6
Glucose	3.7	5.9	9.8	3.1	3.0	-1.6	-1.4
Heart weight	1.2	1.9	5.3	0.5	0.4	-1.3	2.3
Delay discount hyperbolic model param	0.7	1.0	2.7	-0.3	-0.2	1.0	-1.7
Intermittent access intake day 1-15 change	0.0	0.1	0.3	0.1	-0.1	0.0	-0.6
Intermittent access intake escalation	0.0	0.1	0.2	-0.3	-0.5	0.2	-0.3
Intermittent access intake escalation 2	0.4	0.7	1.3	1.1	0.7	-0.8	-0.6
Intermitt. access day 1 inactive lever presses	0.2	2.0	3.5	1.6	1.2	-1.9	0.7
Intermitt. access day 15 inactive lever presses	0.2	1.1	2.2	0.8	0.3	-1.5	1.2
Intermitt. access escalation Index	0.4	1.1	3.7	-0.2	0.2	0.9	-1.9
Intermittent access day 1 total infusions	0.2	0.6	1.5	-1.2	-0.2	0.9	0.0
Intermittent access day 15 total infusions	0.1	0.3	0.8	-0.9	-0.2	0.6	0.1
Intermittent access terminal intake (last 3 days)	0.2	0.4	0.8	-0.9	-0.4	0.3	0.6
Intermittent access total infusions	0.2	0.2	0.6	-0.8	-0.1	0.2	0.4
Intermittent access day 1 locomotion	0.1	0.2	0.4	-0.3	0.6	0.4	-0.3
Intermittent access day 15 total locomotion	0.4	1.5	3.2	0.9	1.0	-1.8	1.0
Intermittent access total locomotion	0.7	0.9	1.7	0.6	0.9	-1.3	0.9
Intermittent access standard deviation	0.2	0.9	3.0	-0.4	-0.5	-0.5	1.7
Left kidney weight	1.0	8.3	21.2	1.4	0.9	-3.0	4.6
Right kidney weight	1.4	9.8	22.4	1.8	1.6	-3.4	4.7
Cocaine induced anxiety	0.2	0.6	1.0	0.9	0.8	-0.4	-1.0
Post-drug Anxiety	0.2	0.2	0.7	0.3	-0.0	0.4	-0.8
Baseline Anxiety	1.1	1.8	2.8	-1.4	-1.5	1.7	-0.2
Tail length	3.5	18.9	25.4	4.5	4.2	-5.0	3.5
Length with tail	6.3	28.1	36.4	5.5	5.1	-6.0	4.5
Length without tail	2.7	14.4	17.3	3.6	3.2	-4.1	4.2
Times rat made contact with spout	2.8	3.2	4.4	-2.1	-1.9	1.9	-1.0
Lifetime Intake	0.2	0.3	0.7	-0.6	0.2	-0.1	0.8
Liver weight, left	3.5	6.1	10.2	3.0	3.2	-2.2	0.5
Liver weight, right	5.4	9.4	12.6	3.4	3.5	-3.2	1.8
Locomotor activity	3.4	5.3	8.7	3.0	2.4	-2.5	0.6
Locomotor testing distance	0.6	1.5	2.8	1.7	1.1	-1.4	0.1
Locomotor testing rearing	0.4	1.5	2.5	1.6	1.3	-1.3	0.4
Locomotion in novel chamber	0.4	0.5	1.1	0.3	0.2	-1.0	0.9
Locomotion in novel chamber post-restriction	0.2	0.5	1.6	-0.2	-0.5	-0.1	1.3
Fecal boli incidents, locomotor time 1	0.2	0.5	1.1	-0.6	0.2	1.1	-0.6
Change in fecal boli incidents, locomotor task	0.7	0.8	1.6	0.8	0.4	-0.9	1.3
Time >=10cm from walls, locomotor time 1	1.4	1.8	2.4	1.5	1.5	-1.2	0.9
Bouts of movement, locomotor time 1	0.4	0.5	1.6	0.5	0.4	0.2	-1.3
Total resting periods, locomotor time 1	0.4	0.4	0.7	0.7	0.8	-0.1	-0.8
Rest time, locomotor task time 1	0.7	1.0	1.8	1.3	1.3	-0.8	0.2
Distance moved, locomotor task time 1	0.2	0.5	1.3	-0.5	-0.6	-0.3	1.1
Vertical activity count, locomotor time 1	0.0	0.3	0.9	-0.5	-0.9	-0.0	0.5
Time >=10cm from walls, locomotor time 2	0.2	0.6	1.1	1.0	1.0	-0.4	0.3
Bouts of movement, locomotor time 2	0.5	1.6	3.3	1.8	1.3	-1.1	0.2
Total resting periods, locomotor time 2	0.5	2.2	4.5	2.1	1.6	-1.3	-0.1
Rest time, locomotor task time 2	2.0	3.3	5.7	2.4	2.3	-1.2	-0.8
Distance moved, locomotor task time 2	1.2	1.6	2.1	-1.4	-1.4	0.4	1.5
Vertical activity count, locomotor time 2	0.3	0.7	1.7	-0.9	-1.3	0.5	0.3
Light reinforcement 1	0.1	0.5	0.8	-0.9	-0.8	0.7	0.5
Light reinforcement 2	0.3	0.7	1.0	1.0	0.9	-0.7	0.8
Bone: marrow area	5.6	13.8	18.3	4.3	4.1	-4.1	1.7
Bone: maximum diameter	2.4	4.9	6.9	2.6	2.5	-2.4	0.6
Bone: maximum force	1.4	2.8	8.6	0.4	0.1	-1.6	2.9
Bone: maximum moment	1.4	2.6	7.2	0.6	0.3	-1.7	2.7
Mean time between licks in bursts	0.6	3.6	5.8	2.4	2.4	-1.5	-0.7
Mean num. licks in bursts	1.0	2.7	4.3	-2.1	-2.0	1.6	-0.4
Cd content in liver	0.7	0.8	1.5	-1.0	-0.8	1.2	-0.2
Co content in liver	1.0	1.1	1.7	-1.2	-1.3	0.4	1.1
Cu content in liver	3.6	4.3	5.2	-2.3	-2.1	2.1	-1.7
Fe content in liver	0.5	0.6	1.2	-0.9	-1.1	0.2	0.7
K content in liver	0.4	0.4	1.0	-0.7	-1.0	0.3	-0.4
Mg content in liver	0.5	0.5	1.2	0.6	0.6	-0.4	-1.1
Mn content in liver	2.6	2.9	3.9	2.0	1.9	-1.1	-1.7
Na content in liver	0.7	0.8	1.7	-1.1	-1.3	0.2	0.5
Rb content in liver	0.6	0.7	1.9	-0.5	-0.6	0.5	-1.4
Se content in liver	2.5	3.0	4.9	2.2	2.1	-1.5	-0.6
Sr content in liver	1.0	0.9	1.2	1.0	0.9	-1.1	0.7
Zn content in liver	0.1	0.1	0.1	0.4	0.3	-0.4	-0.3
Bone: minimum diameter	3.0	5.7	8.6	2.9	2.8	-2.5	0.6
Time in familiar zone, hab. session 1	4.7	5.2	7.6	-2.4	-2.1	2.8	-1.7
Time in novel zone, hab. session 1	3.1	3.5	4.9	2.1	1.8	-2.2	1.2
Total zone transitions, hab. session 1	0.4	0.6	1.0	-0.6	-0.4	0.8	-1.0
Total locomotion distance, hab. session 1	0.4	0.6	1.1	-0.7	-0.6	1.1	-0.7
Locomotion velocity, hab. session 1	0.4	0.5	0.9	-0.8	-0.7	1.0	-0.3
Time in familiar zone, hab. session 2	0.7	0.7	1.1	-1.0	-0.8	1.0	-0.4
Time in novel zone, hab. session 2	0.2	0.3	0.5	0.5	0.3	-0.7	0.5
Total zone transitions, hab. session 2	0.2	0.2	0.3	-0.5	-0.5	0.5	0.2
Total locomotion distance, hab. session 2	0.9	1.2	2.1	-1.0	-0.9	1.5	-0.9
Locomotion velocity, hab. session 2	0.8	1.1	2.0	-0.9	-0.8	1.4	-0.9
Novel to familiar place preference ratio	0.1	0.1	0.2	-0.5	-0.5	0.1	0.2
Novelty place preference	0.1	0.1	0.2	-0.2	-0.3	-0.1	0.4
Time in novel zone, NPP test	0.1	0.1	0.3	-0.1	-0.1	-0.3	0.5
Total zone transitions, NPP test	0.6	0.8	1.7	-0.5	-0.4	1.1	-1.3
Total locomotion distance, NPP test	1.1	1.6	2.6	-1.2	-1.0	1.6	-1.1
Locomotion velocity, NPP test	1.7	2.4	3.8	-1.5	-1.2	2.0	-1.5
Intraocular pressure	0.6	1.0	1.9	-0.7	-0.3	1.2	-1.4
Delta distance traveled before/after self-admin	1.0	1.1	3.7	0.2	0.4	-0.7	1.9
Delta ambulatory time before/after self-admin	0.6	1.0	2.8	0.5	0.6	-0.7	1.7
Parametrial fat weight	0.3	0.7	1.7	0.1	0.1	-1.1	1.3
Pavlov. Cond. lever latency	2.3	2.9	4.7	-2.2	-2.0	1.2	1.1
Pavlov. Cond. magazine entry latency	1.7	2.2	3.1	1.8	1.7	-0.6	-1.5
Pavlov. Cond. change in total contacts	2.0	2.2	3.5	1.9	1.7	-1.6	0.3
Pavlov. Cond. index score	2.5	3.2	5.0	2.2	2.1	-1.0	-1.5
Pavlov. Cond. latency score	2.7	3.4	5.6	2.4	2.2	-1.3	-1.2
Pavlov. Cond. lever contacts	2.4	2.9	5.0	2.2	2.1	-1.3	-0.8
Pavlov. Cond. magazine entry number	1.3	1.7	3.3	-1.3	-1.3	0.2	1.8
Pavlov. Cond. intertrial magazine entries	2.6	3.1	4.6	-2.1	-2.0	1.9	-0.7
Pavlov. Cond. lever-magazine prob. diff.	2.4	2.9	4.3	2.1	2.0	-0.8	-1.7
Pavlov. Cond. response bias	2.1	2.6	3.6	1.9	1.8	-0.6	-1.8
Pavlov. Cond. lever latency	0.4	0.6	0.8	0.7	0.7	-0.9	0.7
Pavlov. Cond. magazine entry latency	0.4	0.5	0.6	0.8	0.7	-0.8	0.7
Pavlov. Cond. change in total contacts	0.1	0.1	0.3	-0.1	-0.3	-0.2	0.6
Pavlov. Cond. index score	0.0	0.0	0.0	0.2	0.2	-0.0	-0.0
Pavlov. Cond. latency score	0.0	0.0	0.0	0.1	0.0	-0.0	0.2
Pavlov. Cond. lever contacts	0.2	0.3	0.5	-0.6	-0.6	0.7	-0.4
Pavlov. Cond. magazine entry number	0.1	0.2	0.4	-0.4	-0.3	0.4	-0.6
Pavlov. Cond. intertrial magazine entries	0.5	1.1	2.3	0.9	1.1	-0.2	-1.5
Pavlov. Cond. lever-magazine prob. diff.	0.0	0.0	0.0	0.2	0.2	0.1	-0.0
Pavlov. Cond. response bias	0.0	0.1	0.2	0.1	0.1	0.2	-0.5
Time in closed arm before self-admin	0.0	0.0	0.0	0.1	-0.1	-0.0	-0.2
Time in closed arm after self-admin	0.5	0.6	1.1	-0.6	-1.0	-0.4	0.9
Time in open arm before self-admin	0.2	0.2	0.5	0.4	0.7	0.1	-0.5
Time in open arm after self-admin	0.5	0.5	1.3	0.7	1.2	0.0	-0.5
Bone: periosteal estimation	3.4	8.0	10.5	3.0	2.8	-3.2	2.1
Bone: periosteal perimeter	2.1	4.2	5.7	2.4	2.2	-2.3	0.9
Bone: post-yield work	1.8	3.1	5.1	2.2	2.2	-1.5	-0.7
Progressive ratio test 1 active lever presses	0.2	0.3	0.7	-0.8	-0.1	0.4	0.7
Progressive ratio test 1 breakpoint	0.2	0.3	0.7	-0.8	-0.1	0.4	0.7
Progressive ratio test 1 inactive lever presses	0.4	1.2	2.3	-1.5	-1.3	0.7	0.4
Progressive ratio test 2 active lever presses	0.4	0.6	1.1	-1.1	-0.6	0.8	-0.2
Progressive ratio test 2 breakpoint	0.5	0.6	1.2	-1.1	-0.7	0.8	-0.2
Progressive ratio test 2 inactive lever presses	0.2	0.7	1.2	0.2	0.7	-0.9	1.1
Incentive Sensitization - Responses	0.2	0.4	0.8	-0.5	-0.3	0.9	-0.8
Incentive Sensitization - Breakpoint	0.2	0.5	0.7	-0.6	-0.4	0.8	-0.9
Sum of active levers in priming session hrs 5-6	0.4	0.4	1.2	0.0	0.3	1.1	-0.5
Progressive ratio	0.9	2.7	9.0	0.2	0.4	-1.3	3.0
Food seeking constrained by brief footshock	0.0	0.1	0.1	-0.3	-0.2	0.2	-0.2
Seeking ratio, punishment vs. effort	1.0	2.2	6.9	-0.3	-0.5	1.3	-2.6
Retroperitoneal fat weight	0.1	0.4	1.5	0.1	0.1	-0.5	1.2
Reaction time number correct	0.5	1.7	3.7	-1.5	-1.9	0.8	0.3
Reaction time mean minus median	0.8	5.1	8.7	2.9	2.9	-1.4	-1.2
Reaction time mean minus median AUC	0.5	3.1	5.2	2.3	2.2	-1.0	-1.2
Reaction time num false alarms	0.3	0.5	0.6	0.7	0.5	-0.7	0.8
Reaction time num false alarms AUC	0.3	0.8	1.3	0.8	0.6	-0.9	1.1
Reaction time trials correct on left	0.5	1.7	3.7	-1.5	-1.9	0.8	0.3
Reaction time trials on left	0.4	1.5	3.3	-1.4	-1.8	0.7	0.4
Reaction time mean	2.1	4.6	7.5	2.7	2.7	-1.3	-1.3
Reaction time mean AUC	1.9	4.6	7.8	2.7	2.8	-1.2	-1.3
Median of all reaction times	1.8	2.8	4.5	2.1	2.1	-1.1	-1.0
Reaction time omissions	2.2	3.5	6.6	2.3	2.6	-1.2	-0.8
Reaction time false alarm rate	1.4	1.9	2.8	1.6	1.7	-1.2	0.8
Reaction time premature initiation rate	0.7	1.0	3.1	0.2	0.1	-1.0	1.8
Reaction time premature initiations	0.4	1.3	3.9	-0.6	-0.9	-0.5	2.0
Std. dev. reaction times	1.8	6.1	10.9	3.2	3.3	-1.7	-0.7
Reaction time trials completed	0.4	1.5	3.3	-1.4	-1.8	0.7	0.4
Reaction time trials AUC	0.4	1.5	3.4	-1.4	-1.9	0.8	0.3
Run reversals in cocaine runway, females	0.5	0.6	1.4	-1.2	-0.6	0.7	0.3
Run reversals in cocaine runway, males	3.6	3.9	5.6	2.3	2.4	-2.1	0.6
Latency to leave start box in cocaine runway	0.0	0.0	0.1	0.1	-0.2	-0.3	0.1
Latency to leave start box in cocaine runway, F	0.1	0.1	0.4	0.1	-0.4	0.0	-0.6
Latency to leave start box in cocaine runway, M	0.7	0.6	1.6	0.2	0.2	-0.9	1.3
Std. dev. time between licks in bursts	2.2	4.1	6.7	2.6	2.4	-2.0	0.0
Total sessions with >9 infusions	0.2	0.3	0.9	-0.4	0.0	-0.3	0.9
Short access day 1 total inactive lever presses	1.9	3.9	6.6	1.8	1.7	-2.6	1.6
Short access day 10 total inactive lever presses	0.0	0.1	0.3	0.1	0.1	-0.3	-0.6
Short access day 1 total infusions	0.0	0.1	0.1	-0.4	0.2	0.2	0.4
Short access day 10 total infusions	0.2	0.3	0.6	-0.7	-0.1	-0.1	0.7
Short access total infusions	0.3	0.4	1.2	-0.6	0.1	-0.2	1.1
Short access day 1 locomotion	0.3	0.5	1.1	-0.6	-0.1	0.8	-1.0
Short access day 10 total locomotion	0.3	1.4	2.3	1.4	1.0	-1.5	0.6
Short access total locomotion	0.2	0.3	0.6	0.4	0.6	-0.8	0.2
One hour access (0.3 mA shock)	0.6	0.7	1.2	-0.8	0.1	1.1	-1.1
Compulsive drug intake	0.8	1.2	3.8	0.4	0.7	0.6	-1.9
One hour access (shock baseline)	0.1	0.2	0.4	-0.6	-0.1	0.4	0.6
Social response proportion	0.5	0.6	0.9	0.9	1.0	-0.6	0.5
Social responses	0.3	0.4	0.9	0.5	0.4	-0.6	1.0
Social time	2.9	4.6	7.4	2.7	2.6	-2.0	-0.0
Soleus weight	3.4	10.1	14.6	3.8	3.8	-3.3	0.8
Bone: stiffness	0.2	0.4	1.0	-0.4	-0.6	-0.2	1.0
Tibialis anterior weight	0.4	1.5	2.9	-1.7	-1.7	0.6	0.3
Time to tail flick, vehicle, before self-admin	0.3	0.4	1.4	0.1	0.1	0.3	-1.2
Time to tail flick, vehicle, after self-admin	0.3	0.6	1.0	0.8	1.0	-0.3	-0.9
Time to tail flick, test, before self-admin	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3
Time to tail flick, test, after self-admin	0.5	0.5	1.6	0.4	0.3	0.4	-1.3
Delta time to tail flick, vehicle, before/after SA	0.1	0.1	0.2	-0.4	-0.3	0.3	-0.2
Delta time to tail flick, test, before/after SA	0.6	0.7	1.0	-0.7	-0.8	1.0	-0.8
Tibia length	3.2	8.8	10.8	3.3	3.0	-3.3	2.3
Ambulatory time before self-admin	0.2	0.5	0.7	0.8	0.8	-0.8	0.1
Ambulatory time after self-admin	1.2	1.9	2.6	1.2	1.6	-1.1	1.5
Bone: tissue strength	1.8	1.8	4.8	0.3	0.2	-1.5	2.2
Total heroin consumption	0.3	0.3	0.9	0.6	1.0	-0.1	0.1
Bone: trabecular number	1.7	3.3	3.9	-1.9	-1.7	2.0	-1.6
Bone: trabecular spacing	3.2	4.7	6.6	1.9	1.7	-2.6	2.3
Bone: trabecular thickness	1.6	2.2	3.1	-1.4	-1.3	1.8	-1.5
Bone: trabecular tissue density	0.6	1.0	3.2	0.4	0.2	-0.7	1.8
Water consumed over 24 hours	0.1	0.1	0.2	0.4	0.3	-0.5	0.2
Number of responses in last shaping day	0.9	1.1	2.0	0.8	0.9	-1.1	1.4