Hub : Genes

LOC102552414

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC102552414	0.05	0.04	9.9e-04	0.02	0.03	0.02	0.03	1.2e-03	2.7e-04	1.4e-03	8.0e-04
2	BLA	gene expression	LOC102552414	0.05	0.03	2.0e-03	0.05	0.03	0.04	0.03	9.1e-04	9.8e-03	5.0e-03	8.0e-03

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Bone: apparent density	1.1	2.0	2.3	-1.5	1.3
Area under the delay curve	2.9	4.5	5.1	2.3	-1.9
BMI with tail	0.8	2.9	3.8	1.9	-1.4
BMI without tail	0.6	3.3	3.4	1.8	-1.8
Body weight	4.0	17.6	20.5	4.5	-3.8
Weight adjusted by age	0.1	0.2	0.3	-0.3	0.6
Bone surface	0.7	1.4	2.0	-0.9	1.4
Bone volume	0.6	1.2	1.5	-0.9	1.2
Breakpoint value in progressive ratio session	1.2	2.2	2.8	1.7	-1.2
Number of licking bursts	0.0	0.1	0.1	0.2	-0.2
Context. condit. distance diff. score	0.5	0.7	1.2	-1.1	0.4
Locomotion velocity, session 1	0.6	0.6	1.2	1.1	-0.2
Locomotion distance, session 1	0.2	0.2	0.4	0.6	-0.1
Locomotion velocity, session 2	0.2	0.3	0.5	0.1	0.7
Locomotion distance, session 2	0.8	1.2	2.2	-0.4	1.5
Locomotion velocity, session 3	0.4	0.5	0.8	0.9	-0.3
Locomotion distance, session 3	1.1	1.3	2.1	1.4	-0.7
Stereotopy head waving bouts, day 3	0.3	0.4	0.5	-0.5	0.7
Stereotopy head waving duration, day 3	0.1	0.1	0.2	-0.4	0.3
Locomotion velocity, session 7	0.3	0.3	0.4	-0.5	0.7
Locomotion distance, session 7	1.3	1.7	2.5	-1.0	1.6
Stereotopy head waving bouts, day 7	0.9	1.0	1.5	0.7	-1.2
Stereotopy head waving duration, day 7	2.0	2.4	2.9	1.4	-1.7
Locomotion velocity, session 8	0.0	0.0	0.0	0.2	0.1
Locomotion distance, session 8	0.1	0.2	0.3	-0.2	0.6
Degree of sensitization distance	5.6	6.0	6.0	-2.5	2.5
Degree of sensitization stereotypy	2.8	3.2	4.2	1.5	-2.1
Conditioned locomotion	1.0	1.2	2.0	-0.6	1.4
Cocaine response after cond. corrected	0.1	0.1	0.2	0.4	0.4
Cocaine response after cond. not corrected	0.1	0.1	0.2	0.5	0.1
Cocaine response before conditioning	0.3	0.4	0.7	0.4	-0.8
Saline control response	1.7	2.3	3.5	-1.1	1.9
Bone: connectivity density	1.7	2.7	3.2	-1.8	1.5
Bone: cortical apparent density	0.7	1.2	2.2	0.3	-1.5
Bone: cortical area	1.7	2.8	3.0	1.7	-1.6
Bone: cortical porosity	0.1	0.1	0.1	0.4	0.2
Bone: cortical porosity	0.2	0.2	0.5	0.7	-0.1
Bone: cortical thickness	1.9	3.2	3.7	1.6	-1.9
Bone: cortical thickness	0.2	0.2	0.2	-0.4	0.5
Bone: cortical tissue density	0.7	1.1	2.0	0.3	-1.4
Condit. Reinf. active minus inactive responses	0.6	0.7	1.2	0.5	-1.1
Condit. Reinf. active-inactive response ratio	0.6	0.6	1.0	0.5	-1.0
Condit. Reinf. active responses	0.8	1.0	1.2	0.9	-1.1
Condit. Reinf. inactive responses	0.7	0.9	1.4	1.2	-0.7
Incentive salience index mean	2.1	2.7	2.8	1.6	-1.7
Condit. Reinf. lever presses	2.6	3.9	5.3	2.3	-1.6
Condit. Reinf. active minus inactive responses	0.3	0.5	0.9	1.0	-0.2
Condit. Reinf. active-inactive response ratio	0.3	0.4	0.5	0.7	-0.5
Condit. Reinf. active responses	0.1	0.1	0.1	0.3	0.3
Condit. Reinf. inactive responses	1.1	1.7	2.1	-1.1	1.4
Condit. Reinf. lever presses	0.0	0.0	0.0	0.2	-0.2
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.1	0.4
Conditioned reinforcement - actives	0.4	1.8	2.9	1.7	-0.8
Conditioned reinforcement - inactives	1.8	5.0	6.0	2.5	-2.0
Conditioned locomotion	0.1	0.2	0.3	-0.3	0.5
Patch foraging indifference point 0 sec	0.1	0.3	0.4	-0.6	0.4
Patch foraging indifference point AUC	0.1	0.2	0.2	0.5	-0.3
Delay disc. indifference point, 0s delay	3.9	4.4	4.6	2.2	-2.0
Delay disc. indifference point, 16s delay	0.7	1.0	1.4	1.2	-0.8
Delay disc. indifference point, 2s delay	4.8	5.3	6.3	2.5	-2.1
Delay disc. indifference point, 24s delay	0.3	0.4	0.5	-0.6	0.7
Delay disc. indifference point, 4s delay	3.3	3.5	3.6	1.9	-1.9
Delay disc. indifference point, 8s delay	2.2	3.6	5.0	2.2	-1.5
Indifference point function ln k	0.0	0.0	0.0	0.2	0.1
Indifference point function log k	0.0	0.0	0.0	0.2	0.1
Patch foraging total patch changes 0 sec	0.2	0.4	0.6	-0.8	0.6
Patch foraging total patch changes 12 sec	0.6	0.8	1.1	-0.7	1.1
Patch foraging total patch changes 18 sec	1.4	3.3	5.3	-2.3	1.2
Patch foraging total patch changes 24 sec	0.1	0.3	0.4	-0.7	0.3
Patch foraging total patch changes 6 sec	0.5	0.8	0.9	-0.9	0.9
Patch foraging time to switch 0 sec	0.3	1.0	1.5	-1.2	0.7
Patch foraging water rate 0 sec	0.1	0.5	0.6	0.8	-0.6
Patch foraging water rate 12 sec	0.0	0.0	0.0	-0.2	0.0
Patch foraging water rate 18 sec	0.2	0.3	0.6	-0.3	0.8
Patch foraging water rate 24 sec	0.5	0.7	0.8	-0.8	0.9
Patch foraging water rate 6 sec	0.8	1.2	1.2	1.1	-1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.4	-0.4	0.7
Distance traveled before self-admin	1.2	2.6	2.9	1.5	-1.7
Distance traveled after self-admin	0.0	0.0	0.0	-0.0	-0.2
Extensor digitorum longus weight	0.2	0.8	0.9	1.0	-0.8
Bone: elastic displacement	4.1	5.1	5.8	2.4	-2.1
Bone: elastic work	2.4	3.2	3.3	1.8	-1.8
Bone: endosteal estimation	0.1	0.3	0.5	0.7	0.2
Bone: endosteal perimeter	0.1	0.3	0.6	0.8	-0.2
Epididymis fat weight	1.5	7.4	8.5	2.9	-2.5
Delta time in closed arm before/after self-admin	0.3	0.3	0.3	-0.5	0.5
Delta time in open arm before/after self-admin	0.0	0.0	0.0	-0.1	-0.2
Diff in mean of infusions in LGA sessions	0.1	0.1	0.2	0.0	-0.5
Delay discount exponential model param	3.0	4.1	4.8	-2.2	1.9
Extinction: sum of active levers before priming	0.0	0.0	0.1	0.3	0.0
Active lever presses in extinction session 6	0.4	0.4	0.8	0.9	-0.2
Bone: final force	0.4	0.6	0.9	0.6	-0.9
Bone: final moment	0.6	1.0	1.2	0.9	-1.1
Food consumed during 24 hour testing period	0.4	0.8	0.9	1.0	-0.8
Glucose	0.2	0.2	0.3	-0.6	0.4
Heart weight	0.9	1.4	1.5	-1.2	1.2
Delay discount hyperbolic model param	3.4	4.4	4.9	-2.2	2.0
Intermittent access intake day 1-15 change	0.6	3.2	3.7	1.9	-1.6
Intermittent access intake escalation	0.5	2.7	2.8	1.7	-1.6
Intermittent access intake escalation 2	1.3	2.2	2.3	1.5	-1.5
Intermitt. access day 1 inactive lever presses	0.1	1.1	1.4	1.2	-0.9
Intermitt. access day 15 inactive lever presses	0.1	0.7	0.9	0.7	-1.0
Intermitt. access escalation Index	1.0	3.1	3.3	-1.7	1.8
Intermittent access day 1 total infusions	0.2	0.5	1.0	0.1	1.0
Intermittent access day 15 total infusions	0.6	1.4	2.5	1.6	-0.6
Intermittent access terminal intake (last 3 days)	0.4	0.6	1.2	1.1	-0.0
Intermittent access total infusions	0.3	0.4	0.5	0.7	0.5
Intermittent access day 1 locomotion	0.9	1.6	2.8	-0.6	1.7
Intermittent access day 15 total locomotion	0.0	0.1	0.1	0.1	0.3
Intermittent access total locomotion	1.3	1.6	2.5	-0.8	1.6
Intermittent access standard deviation	0.1	0.7	1.3	1.1	-0.0
Left kidney weight	2.2	17.4	19.5	3.9	-4.4
Right kidney weight	2.7	18.6	18.8	4.3	-4.3
Cocaine induced anxiety	0.1	0.2	0.3	-0.6	0.2
Post-drug Anxiety	0.2	0.2	0.4	-0.6	0.2
Baseline Anxiety	0.0	0.0	0.1	-0.1	0.3
Tail length	1.5	7.9	8.4	2.7	-2.9
Length with tail	3.9	17.4	19.5	4.4	-3.9
Length without tail	1.8	9.4	12.2	3.5	-2.6
Times rat made contact with spout	0.6	0.7	0.8	0.7	-0.9
Lifetime Intake	0.5	0.6	1.2	1.1	0.1
Liver weight, left	4.1	7.1	7.5	2.7	-2.6
Liver weight, right	1.0	1.8	2.1	1.4	-1.2
Locomotor activity	1.3	2.0	2.9	-1.1	1.7
Locomotor testing distance	1.0	2.6	3.8	-1.2	2.0
Locomotor testing rearing	0.0	0.0	0.1	-0.2	0.2
Locomotion in novel chamber	0.3	0.5	0.8	-0.3	0.9
Locomotion in novel chamber post-restriction	0.1	0.4	0.5	0.7	-0.4
Fecal boli incidents, locomotor time 1	0.9	2.5	4.0	1.0	-2.0
Change in fecal boli incidents, locomotor task	0.2	0.2	0.4	0.2	0.6
Time >=10cm from walls, locomotor time 1	2.0	2.5	3.7	-1.2	1.9
Bouts of movement, locomotor time 1	0.1	0.2	0.3	-0.2	-0.5
Total resting periods, locomotor time 1	0.1	0.2	0.2	-0.3	-0.5
Rest time, locomotor task time 1	0.3	0.5	0.8	-0.9	0.5
Distance moved, locomotor task time 1	0.1	0.2	0.4	0.6	0.1
Vertical activity count, locomotor time 1	0.1	0.5	0.8	-0.4	0.9
Time >=10cm from walls, locomotor time 2	0.2	0.5	0.8	-0.5	0.9
Bouts of movement, locomotor time 2	0.3	0.9	1.0	-1.0	0.9
Total resting periods, locomotor time 2	0.4	1.8	2.3	-1.5	1.1
Rest time, locomotor task time 2	0.9	1.6	2.0	-1.4	1.1
Distance moved, locomotor task time 2	0.1	0.1	0.3	0.5	0.0
Vertical activity count, locomotor time 2	0.5	1.2	1.9	-0.7	1.4
Light reinforcement 1	0.2	1.1	2.1	1.5	-0.4
Light reinforcement 2	0.2	0.5	0.6	0.8	-0.6
Bone: marrow area	0.1	0.2	0.4	0.6	0.3
Bone: maximum diameter	0.4	0.8	1.4	1.2	-0.5
Bone: maximum force	0.1	0.3	0.3	0.5	-0.5
Bone: maximum moment	0.3	0.6	0.7	0.8	-0.7
Mean time between licks in bursts	0.1	0.4	0.8	0.2	-0.9
Mean num. licks in bursts	0.0	0.0	0.0	0.2	-0.2
Cd content in liver	2.3	2.6	3.9	-2.0	1.1
Co content in liver	0.3	0.4	0.7	-0.8	0.1
Cu content in liver	0.4	0.4	0.6	0.8	-0.5
Fe content in liver	0.4	0.5	0.8	-0.3	0.9
K content in liver	1.9	1.9	3.2	1.8	-0.7
Mg content in liver	0.2	0.2	0.4	0.6	0.2
Mn content in liver	0.1	0.1	0.3	0.5	-0.2
Na content in liver	0.1	0.1	0.2	0.3	0.4
Rb content in liver	0.2	0.2	0.2	-0.4	-0.5
Se content in liver	1.3	1.5	2.4	1.6	-0.7
Sr content in liver	0.3	0.2	0.3	-0.4	0.5
Zn content in liver	0.0	0.1	0.1	0.1	-0.3
Bone: minimum diameter	0.3	0.5	0.8	0.9	-0.5
Time in familiar zone, hab. session 1	0.3	0.4	0.5	-0.5	0.7
Time in novel zone, hab. session 1	0.2	0.2	0.4	-0.6	0.3
Total zone transitions, hab. session 1	0.4	0.6	0.9	0.9	0.5
Total locomotion distance, hab. session 1	0.4	0.6	1.2	1.1	-0.1
Locomotion velocity, hab. session 1	1.3	1.9	3.1	1.8	-0.8
Time in familiar zone, hab. session 2	2.6	3.0	4.1	-2.0	1.4
Time in novel zone, hab. session 2	1.2	1.4	1.7	1.3	-1.0
Total zone transitions, hab. session 2	0.1	0.2	0.3	0.3	0.5
Total locomotion distance, hab. session 2	0.0	0.0	0.1	0.3	-0.1
Locomotion velocity, hab. session 2	0.0	0.1	0.1	0.3	0.2
Novel to familiar place preference ratio	0.3	0.4	0.7	-0.8	0.5
Novelty place preference	0.4	0.6	0.8	-0.9	0.6
Time in novel zone, NPP test	0.3	0.4	0.6	-0.8	0.4
Total zone transitions, NPP test	1.2	1.8	2.6	1.6	-0.9
Total locomotion distance, NPP test	0.7	1.0	1.2	1.1	-0.9
Locomotion velocity, NPP test	0.3	0.4	0.6	0.8	-0.5
Intraocular pressure	0.0	0.0	0.0	-0.2	0.2
Delta distance traveled before/after self-admin	1.0	1.1	1.2	-1.1	1.0
Delta ambulatory time before/after self-admin	1.7	2.9	3.3	-1.6	1.8
Parametrial fat weight	0.2	0.5	0.7	-0.5	0.9
Pavlov. Cond. lever latency	4.7	5.9	6.4	-2.5	2.3
Pavlov. Cond. magazine entry latency	1.0	1.3	2.1	1.5	-0.7
Pavlov. Cond. change in total contacts	5.6	6.0	6.1	2.5	-2.5
Pavlov. Cond. index score	3.7	4.6	6.0	2.4	-1.8
Pavlov. Cond. latency score	4.4	5.6	6.7	2.6	-2.1
Pavlov. Cond. lever contacts	3.9	4.6	5.2	2.3	-2.0
Pavlov. Cond. magazine entry number	1.1	1.4	2.1	-1.5	0.8
Pavlov. Cond. intertrial magazine entries	0.4	0.5	0.5	0.7	-0.7
Pavlov. Cond. lever-magazine prob. diff.	4.0	4.9	6.2	2.5	-1.9
Pavlov. Cond. response bias	2.5	3.1	4.4	2.1	-1.3
Pavlov. Cond. lever latency	0.4	0.5	0.7	0.8	-0.6
Pavlov. Cond. magazine entry latency	2.1	3.0	4.2	-2.1	1.4
Pavlov. Cond. change in total contacts	0.2	0.6	0.7	-0.8	0.7
Pavlov. Cond. index score	0.5	0.8	1.3	-1.1	0.6
Pavlov. Cond. latency score	0.3	0.5	0.8	-0.9	0.5
Pavlov. Cond. lever contacts	0.5	0.7	0.9	-1.0	0.7
Pavlov. Cond. magazine entry number	0.8	1.0	1.7	1.3	-0.6
Pavlov. Cond. intertrial magazine entries	0.4	0.8	1.7	1.3	0.0
Pavlov. Cond. lever-magazine prob. diff.	0.4	0.6	0.9	-1.0	0.5
Pavlov. Cond. response bias	1.5	2.0	2.7	-1.6	1.2
Time in closed arm before self-admin	0.2	0.4	0.4	-0.6	0.6
Time in closed arm after self-admin	0.5	0.5	0.7	-0.9	0.6
Time in open arm before self-admin	0.1	0.1	0.3	0.5	-0.1
Time in open arm after self-admin	0.0	0.0	0.0	-0.0	0.1
Bone: periosteal estimation	0.5	1.2	1.9	1.4	-0.7
Bone: periosteal perimeter	1.0	1.9	2.7	1.6	-1.0
Bone: post-yield work	0.6	1.0	1.3	-0.9	1.1
Progressive ratio test 1 active lever presses	0.1	0.2	0.3	0.5	0.5
Progressive ratio test 1 breakpoint	0.2	0.3	0.3	0.5	0.6
Progressive ratio test 1 inactive lever presses	0.0	0.0	0.1	0.0	0.2
Progressive ratio test 2 active lever presses	1.0	1.4	1.9	1.4	-1.0
Progressive ratio test 2 breakpoint	1.0	1.3	1.7	1.3	-0.9
Progressive ratio test 2 inactive lever presses	0.6	1.8	2.2	1.5	-1.2
Incentive Sensitization - Responses	0.2	0.5	0.8	0.4	-0.9
Incentive Sensitization - Breakpoint	0.2	0.4	0.7	0.4	-0.8
Sum of active levers in priming session hrs 5-6	0.2	0.2	0.4	0.6	-0.3
Progressive ratio	0.1	0.2	0.3	0.6	-0.2
Food seeking constrained by brief footshock	0.0	0.0	0.1	0.3	-0.1
Seeking ratio, punishment vs. effort	0.0	0.1	0.1	-0.3	0.2
Retroperitoneal fat weight	0.1	0.4	0.4	0.6	-0.6
Reaction time number correct	0.2	0.8	1.0	-1.0	0.8
Reaction time mean minus median	0.1	0.9	1.4	0.5	-1.2
Reaction time mean minus median AUC	0.0	0.3	0.5	0.2	-0.7
Reaction time num false alarms	0.8	1.3	1.8	1.3	-0.9
Reaction time num false alarms AUC	0.3	0.7	1.0	1.0	-0.5
Reaction time trials correct on left	0.2	0.8	1.0	-1.0	0.8
Reaction time trials on left	0.3	0.9	1.1	-1.0	0.8
Reaction time mean	0.1	0.1	0.2	-0.0	-0.5
Reaction time mean AUC	0.0	0.0	0.1	-0.2	-0.1
Median of all reaction times	0.0	0.0	0.0	-0.2	-0.1
Reaction time omissions	0.7	1.1	1.5	-1.2	0.9
Reaction time false alarm rate	1.4	2.0	2.8	1.7	-1.1
Reaction time premature initiation rate	0.2	0.3	0.6	0.1	-0.8
Reaction time premature initiations	0.1	0.2	0.5	-0.7	0.1
Std. dev. reaction times	0.0	0.1	0.1	-0.4	-0.3
Reaction time trials completed	0.3	0.9	1.1	-1.0	0.8
Reaction time trials AUC	0.1	0.4	0.5	-0.7	0.6
Run reversals in cocaine runway, females	2.7	3.0	4.6	-2.1	1.2
Run reversals in cocaine runway, males	0.3	0.3	0.5	0.7	-0.4
Latency to leave start box in cocaine runway	0.2	0.2	0.5	0.0	-0.7
Latency to leave start box in cocaine runway, F	0.7	0.9	1.7	0.3	-1.3
Latency to leave start box in cocaine runway, M	0.1	0.1	0.1	-0.3	0.2
Std. dev. time between licks in bursts	1.1	2.0	2.4	1.3	-1.5
Total sessions with >9 infusions	0.8	1.0	1.9	1.4	0.2
Short access day 1 total inactive lever presses	0.0	0.1	0.1	0.1	0.4
Short access day 10 total inactive lever presses	0.1	0.7	1.3	-1.2	0.1
Short access day 1 total infusions	0.2	0.5	1.0	1.0	-0.1
Short access day 10 total infusions	0.4	0.6	1.3	-0.2	1.1
Short access total infusions	0.3	0.4	0.9	0.9	-0.0
Short access day 1 locomotion	0.2	0.3	0.4	0.6	0.5
Short access day 10 total locomotion	0.2	0.6	1.1	0.4	1.1
Short access total locomotion	0.7	1.0	2.0	-0.0	1.4
One hour access (0.3 mA shock)	2.8	3.3	5.8	2.4	-0.9
Compulsive drug intake	0.3	0.4	0.9	0.1	-0.9
One hour access (shock baseline)	0.6	1.5	2.9	1.7	0.1
Social response proportion	0.4	0.5	0.6	-0.7	0.8
Social responses	0.3	0.4	0.8	0.9	0.2
Social time	0.8	1.3	2.2	-1.5	0.6
Soleus weight	0.4	1.2	1.9	1.4	-0.6
Bone: stiffness	0.0	0.0	0.1	-0.3	0.1
Tibialis anterior weight	0.0	0.0	0.1	0.3	-0.1
Time to tail flick, vehicle, before self-admin	0.7	0.9	1.5	0.5	-1.2
Time to tail flick, vehicle, after self-admin	0.0	0.0	0.1	-0.3	-0.0
Time to tail flick, test, before self-admin	0.2	0.2	0.3	-0.3	-0.5
Time to tail flick, test, after self-admin	0.5	0.6	0.9	-0.9	0.5
Delta time to tail flick, vehicle, before/after SA	1.8	1.9	2.4	-1.2	1.5
Delta time to tail flick, test, before/after SA	0.4	0.5	0.6	-0.6	0.8
Tibia length	10.2	28.5	31.9	5.7	-5.0
Ambulatory time before self-admin	1.0	3.0	4.0	1.4	-2.0
Ambulatory time after self-admin	0.0	0.0	0.0	-0.2	-0.2
Bone: tissue strength	1.5	1.6	1.6	1.3	-1.2
Total heroin consumption	0.7	0.8	1.4	1.2	-0.5
Bone: trabecular number	0.6	1.2	1.5	-1.2	0.9
Bone: trabecular spacing	0.2	0.3	0.3	0.5	-0.6
Bone: trabecular thickness	0.8	1.1	1.2	-1.1	1.0
Bone: trabecular tissue density	0.5	0.8	1.5	0.3	-1.2
Water consumed over 24 hours	0.0	0.0	0.0	0.2	-0.2
Number of responses in last shaping day	0.9	1.2	2.3	1.5	-0.4