Hub : Genes

LOC102551152

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	PL	gene expression	LOC102551152	0.05	0.02	1.4e-07	0.06	0.07	0.07	0.07	1.1e-07	8.3e-08	1.1e-07	6.9e-08
2	Brain	mRNA stability	LOC102551152	0.04	0.02	1.3e-04	0.05	0.05	0.04	0.05	1.9e-05	1.8e-05	1.8e-04	2.6e-05
3	Liver	gene expression	LOC102551152	0.15	0.07	8.1e-11	0.07	0.06	0.06	0.06	3.8e-08	1.4e-07	5.3e-07	1.1e-07
4	BLA	gene expression	LOC102551152	0.09	0.04	2.4e-04	0.06	0.06	0.04	0.05	3.1e-04	3.5e-04	4.5e-03	1.3e-03
5	Brain	gene expression	LOC102551152	0.13	0.05	0.0e+00	0.21	0.19	0.18	0.2	3.8e-19	4.0e-17	2.0e-16	1.1e-18
6	pVTA	gene expression	LOC102551152	0.05	0.04	1.8e-03	0.04	0.03	0.04	0.04	8.1e-04	9.4e-04	5.6e-04	3.9e-04
7	IC	gene expression	LOC102551152	0.11	0.06	9.5e-06	0.14	0.14	0.11	0.15	1.4e-06	1.8e-06	2.8e-05	9.6e-07

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bone: apparent density	0.1	0.2	1.0	1.0	0.4	-0.0	-0.2	-0.2	0.3	0.1
Area under the delay curve	0.6	0.9	1.7	-1.3	-0.9	0.8	0.9	0.9	-0.5	-1.0
BMI with tail	1.5	5.1	7.8	-2.5	-2.4	2.2	2.0	2.0	-2.8	-2.0
BMI without tail	1.0	5.4	6.9	-2.0	-2.4	2.5	2.3	2.3	-2.6	-2.0
Body weight	2.4	10.7	15.5	-3.9	-3.3	3.1	3.2	3.2	-3.4	-2.8
Weight adjusted by age	0.1	0.2	0.6	0.2	-0.3	-0.3	-0.8	-0.8	0.2	0.1
Bone surface	0.1	0.2	0.4	-0.4	-0.4	0.6	0.3	0.3	-0.6	-0.7
Bone volume	0.1	0.2	0.9	0.9	0.6	-0.1	-0.4	-0.4	0.4	0.2
Breakpoint value in progressive ratio session	0.1	0.1	0.6	0.8	0.4	-0.4	-0.3	-0.3	0.1	0.0
Number of licking bursts	0.1	0.2	0.6	0.8	0.3	-0.2	0.0	0.0	0.3	0.8
Context. condit. distance diff. score	1.3	1.6	3.1	1.4	1.1	-1.0	-1.2	-1.2	1.1	1.7
Locomotion velocity, session 1	0.3	0.4	1.0	1.0	0.6	-0.3	-0.1	-0.1	0.6	0.8
Locomotion distance, session 1	0.9	1.1	1.8	1.3	1.2	-0.9	-0.8	-0.8	1.1	1.2
Locomotion velocity, session 2	0.2	0.2	0.4	0.6	0.0	0.3	0.6	0.6	0.4	0.1
Locomotion distance, session 2	1.8	2.5	4.9	2.2	1.7	-1.1	-1.2	-1.2	1.6	1.6
Locomotion velocity, session 3	0.5	0.5	1.3	0.4	0.5	-0.5	-0.6	-0.6	1.0	1.1
Locomotion distance, session 3	0.4	0.5	1.1	0.0	0.5	-0.7	-0.6	-0.6	1.1	0.9
Stereotopy head waving bouts, day 3	0.8	1.0	1.4	0.6	1.2	-1.1	-0.9	-0.9	1.0	1.2
Stereotopy head waving duration, day 3	0.1	0.1	0.5	-0.7	-0.0	0.1	0.2	0.2	-0.6	-0.3
Locomotion velocity, session 7	0.5	0.5	1.4	0.7	0.4	-0.5	-0.6	-0.6	0.7	1.2
Locomotion distance, session 7	0.1	0.1	0.3	0.4	-0.1	0.5	0.4	0.4	0.1	0.3
Stereotopy head waving bouts, day 7	1.6	1.9	3.4	0.8	1.1	-1.5	-1.5	-1.5	1.1	1.8
Stereotopy head waving duration, day 7	0.3	0.3	0.6	0.0	0.2	-0.7	-0.7	-0.7	0.3	0.7
Locomotion velocity, session 8	3.3	4.0	7.1	2.7	1.8	-1.4	-1.7	-1.7	2.1	2.3
Locomotion distance, session 8	1.4	2.0	3.8	2.0	1.2	-0.9	-1.1	-1.1	1.5	1.8
Degree of sensitization distance	0.2	0.2	0.5	0.7	0.0	0.5	0.3	0.3	-0.5	-0.1
Degree of sensitization stereotypy	1.1	1.3	2.4	0.7	0.8	-1.1	-1.3	-1.3	0.7	1.5
Conditioned locomotion	0.1	0.1	0.1	-0.3	0.2	-0.2	-0.3	-0.3	0.0	-0.2
Cocaine response after cond. corrected	0.4	0.6	1.0	-0.4	-0.8	1.0	0.8	0.8	-0.7	-0.8
Cocaine response after cond. not corrected	0.5	0.8	1.6	-0.4	-0.9	1.2	0.9	0.9	-0.9	-0.7
Cocaine response before conditioning	0.1	0.1	0.3	0.3	0.2	0.0	-0.3	-0.3	0.2	0.5
Saline control response	0.3	0.4	0.6	-0.5	-0.6	0.8	0.6	0.6	-0.8	-0.5
Bone: connectivity density	0.1	0.1	0.2	-0.3	-0.2	0.1	0.3	0.3	-0.4	-0.5
Bone: cortical apparent density	2.1	3.2	4.1	1.5	1.7	-1.7	-2.0	-2.0	1.7	1.9
Bone: cortical area	0.8	1.3	3.1	0.1	1.0	-1.2	-1.8	-1.8	0.6	0.3
Bone: cortical porosity	0.1	0.1	0.3	0.3	0.5	-0.0	-0.0	-0.0	-0.4	0.6
Bone: cortical porosity	0.6	0.7	1.3	0.8	1.1	-0.7	-0.7	-0.7	0.1	1.1
Bone: cortical thickness	2.2	3.6	7.1	0.9	1.7	-2.0	-2.7	-2.7	1.3	1.3
Bone: cortical thickness	0.2	0.3	0.6	-0.7	-0.5	0.8	0.2	0.2	-0.7	-0.3
Bone: cortical tissue density	1.9	3.0	3.6	1.5	1.6	-1.7	-1.9	-1.9	1.7	1.9
Condit. Reinf. active minus inactive responses	0.1	0.2	0.6	0.7	-0.2	0.3	0.0	0.0	-0.3	0.6
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.4	0.3	-0.3	0.3	-0.1	-0.1	-0.6	0.3
Condit. Reinf. active responses	0.2	0.3	0.7	0.8	-0.4	0.5	0.4	0.4	-0.2	0.5
Condit. Reinf. inactive responses	0.2	0.2	0.5	0.3	-0.5	0.5	0.7	0.7	0.2	-0.1
Incentive salience index mean	0.4	0.5	0.9	0.4	-0.7	1.0	1.0	1.0	-0.6	0.1
Condit. Reinf. lever presses	0.2	0.4	0.9	0.2	-0.5	0.6	1.0	1.0	-0.1	0.1
Condit. Reinf. active minus inactive responses	0.4	0.5	2.1	1.4	0.5	-0.0	-0.5	-0.5	0.7	0.7
Condit. Reinf. active-inactive response ratio	0.1	0.1	0.5	0.7	0.2	0.1	-0.0	-0.0	0.1	0.2
Condit. Reinf. active responses	0.6	0.8	2.2	1.5	0.6	-0.3	-0.8	-0.8	0.9	0.9
Condit. Reinf. inactive responses	0.1	0.2	0.3	-0.2	-0.6	0.6	0.3	0.3	-0.3	-0.3
Condit. Reinf. lever presses	0.3	0.5	1.6	1.3	0.5	-0.1	-0.5	-0.5	0.5	0.7
Condit. Reinf. lever reinforcers received	0.4	0.6	1.7	1.3	0.5	-0.2	-0.7	-0.7	0.7	0.8
Conditioned reinforcement - actives	0.3	1.2	2.4	-1.5	-1.1	0.7	0.8	0.8	-1.0	-1.5
Conditioned reinforcement - inactives	0.1	0.2	0.5	-0.2	0.2	-0.5	-0.7	-0.7	0.3	0.1
Conditioned locomotion	0.2	0.4	0.7	-0.8	0.3	-0.8	-0.6	-0.6	0.7	-0.1
Patch foraging indifference point 0 sec	0.9	2.6	3.9	-1.7	-2.0	1.6	1.6	1.6	-1.4	-1.4
Patch foraging indifference point AUC	0.1	0.3	0.7	-0.6	-0.4	0.4	0.6	0.6	-0.5	-0.9
Delay disc. indifference point, 0s delay	0.5	0.6	1.6	1.3	0.6	-0.1	-0.5	-0.5	0.7	1.1
Delay disc. indifference point, 16s delay	0.4	0.5	1.9	-1.4	-0.5	0.2	0.2	0.2	-0.1	-1.1
Delay disc. indifference point, 2s delay	0.0	0.1	0.1	-0.2	-0.3	0.3	0.2	0.2	0.2	0.2
Delay disc. indifference point, 24s delay	2.1	3.3	4.0	-1.7	-1.9	1.9	2.0	2.0	-1.3	-1.9
Delay disc. indifference point, 4s delay	0.2	0.2	0.4	0.3	0.0	0.4	0.6	0.6	-0.2	0.1
Delay disc. indifference point, 8s delay	1.3	2.2	3.0	-1.7	-1.4	1.5	1.5	1.5	-1.2	-1.4
Indifference point function ln k	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.1	-0.3	-0.0
Indifference point function log k	0.0	0.0	0.1	-0.1	-0.1	0.1	-0.1	-0.1	-0.3	-0.0
Patch foraging total patch changes 0 sec	0.9	2.8	3.9	-1.8	-2.0	1.6	1.7	1.7	-1.3	-1.5
Patch foraging total patch changes 12 sec	1.2	1.7	1.9	-1.4	-1.4	1.2	1.3	1.3	-1.4	-1.1
Patch foraging total patch changes 18 sec	0.2	0.4	1.2	-1.1	-0.8	0.5	0.5	0.5	-0.5	-0.5
Patch foraging total patch changes 24 sec	0.7	2.2	4.8	-2.2	-1.6	1.2	1.1	1.1	-1.5	-1.3
Patch foraging total patch changes 6 sec	1.8	3.0	3.8	-1.5	-2.0	1.6	1.9	1.9	-1.6	-1.5
Patch foraging time to switch 0 sec	0.0	0.1	0.2	0.1	-0.1	0.3	-0.5	-0.5	0.0	0.5
Patch foraging water rate 0 sec	0.1	0.4	0.9	-1.0	-0.4	0.0	0.8	0.8	-0.4	-0.6
Patch foraging water rate 12 sec	0.3	1.2	2.2	0.5	1.0	-1.0	-1.3	-1.3	0.6	1.5
Patch foraging water rate 18 sec	0.1	0.2	0.6	-0.7	-0.4	0.3	-0.1	-0.1	-0.8	-0.2
Patch foraging water rate 24 sec	0.9	1.3	2.0	-1.4	-0.9	1.1	1.2	1.2	-1.2	-1.0
Patch foraging water rate 6 sec	0.9	1.3	2.8	0.1	1.3	-1.7	-0.8	-0.8	1.3	1.1
Seeking ratio, delayed vs. immediate footshock	0.2	0.3	0.8	0.5	-0.1	0.5	0.9	0.9	-0.0	-0.1
Distance traveled before self-admin	0.0	0.1	0.4	-0.4	-0.2	0.1	0.1	0.1	-0.6	0.1
Distance traveled after self-admin	1.2	2.2	2.9	-0.6	-1.6	1.7	1.7	1.7	-1.4	-1.3
Extensor digitorum longus weight	0.0	0.2	0.7	-0.8	-0.4	0.3	0.2	0.2	-0.3	-0.5
Bone: elastic displacement	1.8	2.3	3.7	1.0	1.8	-1.9	-1.7	-1.7	1.1	1.3
Bone: elastic work	0.7	0.9	1.5	0.5	1.2	-1.2	-1.1	-1.1	0.4	0.5
Bone: endosteal estimation	0.4	1.0	1.4	-0.8	-1.0	1.2	1.0	1.0	-1.0	-1.0
Bone: endosteal perimeter	0.1	0.3	0.5	-0.1	-0.5	0.6	0.4	0.4	-0.7	-0.6
Epididymis fat weight	1.1	5.8	8.1	-2.8	-2.6	2.5	2.0	2.0	-2.8	-1.8
Delta time in closed arm before/after self-admin	1.3	1.2	1.8	0.6	1.2	-1.3	-1.3	-1.3	1.1	0.6
Delta time in open arm before/after self-admin	0.2	0.3	0.9	-0.1	-0.9	0.6	0.0	0.0	-0.8	-0.0
Diff in mean of infusions in LGA sessions	0.4	0.7	1.1	0.6	1.0	-1.1	-1.0	-1.0	0.4	0.4
Delay discount exponential model param	0.8	1.1	1.9	1.4	1.0	-0.9	-1.0	-1.0	0.6	1.1
Extinction: sum of active levers before priming	0.0	0.1	0.3	0.5	-0.2	-0.1	-0.0	-0.0	-0.1	0.3
Active lever presses in extinction session 6	0.3	0.3	1.0	-1.0	-0.4	0.1	0.2	0.2	0.1	-0.9
Bone: final force	0.2	0.4	0.9	0.3	0.6	-0.4	-0.9	-0.9	-0.2	0.4
Bone: final moment	0.2	0.3	0.7	0.1	0.4	-0.3	-0.8	-0.8	-0.4	0.3
Food consumed during 24 hour testing period	0.2	0.4	1.2	0.0	-0.8	1.1	0.0	0.0	-0.9	-0.1
Glucose	2.3	3.6	5.4	2.3	1.9	-1.7	-1.8	-1.8	1.9	1.9
Heart weight	1.2	2.0	3.2	-1.5	-1.6	1.5	1.2	1.2	-1.8	-1.0
Delay discount hyperbolic model param	0.6	0.8	1.4	1.2	0.9	-0.8	-0.9	-0.9	0.5	1.0
Intermittent access intake day 1-15 change	0.1	0.7	0.9	0.5	0.8	-1.0	-1.0	-1.0	0.7	0.9
Intermittent access intake escalation	0.2	0.8	1.0	0.7	0.8	-1.0	-1.0	-1.0	0.8	1.0
Intermittent access intake escalation 2	0.2	0.4	0.7	0.3	0.6	-0.8	-0.7	-0.7	0.5	0.4
Intermitt. access day 1 inactive lever presses	0.3	3.9	5.7	0.8	1.9	-2.3	-2.4	-2.4	2.0	1.7
Intermitt. access day 15 inactive lever presses	0.7	3.9	4.9	1.4	1.7	-2.1	-2.2	-2.2	1.9	2.1
Intermitt. access escalation Index	0.2	0.5	0.7	0.8	0.7	-0.7	-0.8	-0.8	0.5	0.8
Intermittent access day 1 total infusions	1.1	3.2	6.9	-2.6	-2.0	1.3	1.3	1.3	-2.0	-1.6
Intermittent access day 15 total infusions	0.1	0.2	0.9	-0.9	-0.6	0.1	-0.1	-0.1	-0.5	0.0
Intermittent access terminal intake (last 3 days)	0.1	0.2	0.7	-0.8	-0.4	-0.2	-0.3	-0.3	-0.3	0.1
Intermittent access total infusions	0.6	0.7	1.9	-1.4	-1.0	0.6	0.5	0.5	-1.0	-0.6
Intermittent access day 1 locomotion	0.5	1.0	3.2	-1.8	-1.0	0.7	0.4	0.4	-1.3	-0.8
Intermittent access day 15 total locomotion	0.5	1.8	5.3	-2.3	-1.5	0.8	0.6	0.6	-1.6	-1.1
Intermittent access total locomotion	0.4	0.5	2.4	-1.5	-0.6	0.1	0.0	0.0	-0.7	-0.4
Intermittent access standard deviation	0.0	0.2	0.4	-0.1	0.1	-0.5	-0.5	-0.5	0.4	0.6
Left kidney weight	3.5	27.9	31.4	-5.6	-5.4	5.3	5.2	5.2	-5.4	-4.8
Right kidney weight	3.8	26.5	31.4	-5.6	-5.3	4.9	5.2	5.2	-5.2	-4.6
Cocaine induced anxiety	0.0	0.1	0.3	-0.4	-0.2	0.0	0.3	0.3	0.1	-0.5
Post-drug Anxiety	0.7	0.8	1.8	-1.3	-0.8	0.6	0.8	0.8	-0.6	-1.0
Baseline Anxiety	0.1	0.1	0.2	-0.5	-0.2	0.4	0.2	0.2	-0.2	0.3
Tail length	1.0	5.2	7.2	-2.0	-2.1	2.5	2.7	2.7	-2.0	-1.8
Length with tail	1.8	8.1	11.7	-3.4	-2.8	2.6	3.0	3.0	-2.4	-2.5
Length without tail	0.7	3.9	6.4	-2.5	-2.0	1.8	2.0	2.0	-1.7	-1.7
Times rat made contact with spout	1.3	1.5	2.8	-0.5	-1.4	1.7	1.0	1.0	-1.6	-0.8
Lifetime Intake	0.6	0.8	2.2	-1.5	-1.0	0.6	0.6	0.6	-1.0	-0.6
Liver weight, left	3.7	6.4	8.8	-2.1	-2.6	3.0	2.5	2.5	-2.9	-1.9
Liver weight, right	2.8	5.0	5.9	-2.4	-2.1	2.4	2.4	2.4	-2.1	-1.9
Locomotor activity	0.0	0.0	0.1	-0.2	-0.3	0.2	0.2	0.2	-0.1	0.3
Locomotor testing distance	0.6	1.5	2.7	-1.4	-1.6	1.4	0.9	0.9	-1.1	-1.1
Locomotor testing rearing	0.3	1.0	1.4	-1.0	-1.2	1.1	0.7	0.7	-1.0	-1.0
Locomotion in novel chamber	0.4	0.5	1.0	1.0	0.7	-0.7	-0.3	-0.3	0.7	0.8
Locomotion in novel chamber post-restriction	0.1	0.3	0.8	0.5	0.2	0.6	0.9	0.9	-0.0	-0.1
Fecal boli incidents, locomotor time 1	0.1	0.2	0.7	-0.8	0.1	-0.7	-0.4	-0.4	0.0	-0.1
Change in fecal boli incidents, locomotor task	0.1	0.1	0.5	0.7	0.3	0.1	-0.0	-0.0	0.3	0.2
Time >=10cm from walls, locomotor time 1	0.8	0.9	2.0	-0.2	1.1	-1.4	-1.2	-1.2	0.8	0.1
Bouts of movement, locomotor time 1	0.2	0.2	0.7	-0.0	-0.6	0.6	0.3	0.3	-0.8	-0.3
Total resting periods, locomotor time 1	0.3	0.3	0.7	-0.1	-0.7	0.6	0.5	0.5	-0.8	-0.4
Rest time, locomotor task time 1	0.4	0.6	1.8	1.0	0.7	-0.5	-0.5	-0.5	0.4	1.3
Distance moved, locomotor task time 1	0.4	1.0	2.2	-1.1	-1.1	1.1	0.8	0.8	-0.5	-1.5
Vertical activity count, locomotor time 1	0.1	0.8	2.7	-1.0	-0.8	0.8	0.5	0.5	-0.3	-1.6
Time >=10cm from walls, locomotor time 2	0.0	0.1	0.2	-0.4	-0.1	0.2	0.2	0.2	0.0	-0.2
Bouts of movement, locomotor time 2	0.0	0.0	0.1	-0.3	0.0	-0.1	-0.1	-0.1	0.1	-0.0
Total resting periods, locomotor time 2	0.0	0.1	0.2	0.2	0.3	-0.3	-0.4	-0.4	0.2	0.4
Rest time, locomotor task time 2	1.1	1.9	2.8	1.5	1.1	-1.1	-1.7	-1.7	0.6	1.7
Distance moved, locomotor task time 2	1.2	1.5	2.2	-1.2	-1.2	1.5	1.3	1.3	-0.8	-1.3
Vertical activity count, locomotor time 2	0.3	0.7	1.3	-0.6	-0.7	1.1	0.8	0.8	-0.6	-0.9
Light reinforcement 1	0.5	2.4	2.9	-1.3	-1.4	1.6	1.7	1.7	-1.6	-1.6
Light reinforcement 2	0.2	0.4	1.6	-1.3	-0.3	0.1	0.3	0.3	-0.7	-0.6
Bone: marrow area	0.4	1.0	1.3	-0.8	-1.0	1.2	1.0	1.0	-1.0	-1.0
Bone: maximum diameter	0.3	0.7	1.5	-1.2	-0.7	0.5	0.3	0.3	-1.0	-1.2
Bone: maximum force	0.1	0.1	0.4	0.1	0.1	0.0	-0.6	-0.6	-0.5	-0.1
Bone: maximum moment	0.1	0.1	0.4	-0.2	-0.1	0.1	-0.5	-0.5	-0.6	-0.2
Mean time between licks in bursts	0.1	0.3	0.7	-0.6	-0.5	0.6	0.4	0.4	-0.8	-0.7
Mean num. licks in bursts	0.3	0.8	1.4	-0.9	-1.0	1.1	0.5	0.5	-1.1	-1.2
Cd content in liver	0.1	0.2	0.4	0.6	0.2	-0.2	-0.5	-0.5	0.1	0.4
Co content in liver	0.5	0.6	1.9	-0.2	-0.9	1.4	0.5	0.5	-0.7	-0.7
Cu content in liver	0.1	0.1	0.2	0.2	0.2	-0.2	-0.4	-0.4	0.5	0.2
Fe content in liver	1.1	1.4	2.1	1.4	1.5	-0.9	-1.1	-1.1	0.8	1.2
K content in liver	1.1	1.1	1.9	-0.7	-1.0	1.4	1.2	1.2	-0.6	-1.0
Mg content in liver	0.8	0.9	1.0	0.7	1.0	-0.8	-1.0	-1.0	1.0	0.9
Mn content in liver	2.4	2.7	3.2	1.5	1.8	-1.6	-1.7	-1.7	1.6	1.8
Na content in liver	1.0	1.1	1.6	-0.9	-1.1	1.1	1.3	1.3	-0.8	-1.0
Rb content in liver	0.0	0.0	0.1	-0.2	0.0	0.1	-0.3	-0.3	-0.2	-0.2
Se content in liver	1.3	1.5	2.3	1.2	1.1	-1.1	-1.1	-1.1	1.5	1.5
Sr content in liver	0.2	0.1	0.2	-0.0	-0.5	0.5	0.5	0.5	-0.3	-0.3
Zn content in liver	0.0	0.0	0.1	-0.2	-0.1	-0.0	-0.0	-0.0	0.3	0.1
Bone: minimum diameter	2.0	3.9	5.9	1.4	1.9	-2.0	-2.4	-2.4	1.7	1.6
Time in familiar zone, hab. session 1	0.0	0.0	0.2	-0.1	0.2	-0.2	-0.1	-0.1	-0.1	0.4
Time in novel zone, hab. session 1	1.7	1.9	3.1	-1.0	-1.8	1.5	1.2	1.2	-1.4	-1.5
Total zone transitions, hab. session 1	0.5	0.7	1.2	1.1	0.9	-0.7	-0.5	-0.5	1.0	1.0
Total locomotion distance, hab. session 1	0.5	0.7	1.1	0.8	1.0	-0.9	-0.6	-0.6	0.9	1.0
Locomotion velocity, hab. session 1	1.0	1.4	2.3	1.1	1.5	-1.3	-0.9	-0.9	1.3	1.2
Time in familiar zone, hab. session 2	1.5	1.7	3.0	-1.7	-1.2	1.0	1.2	1.2	-1.4	-1.4
Time in novel zone, hab. session 2	0.1	0.1	0.7	0.8	0.1	0.2	-0.2	-0.2	0.3	0.3
Total zone transitions, hab. session 2	0.1	0.2	0.4	0.2	-0.2	0.4	0.6	0.6	0.3	0.1
Total locomotion distance, hab. session 2	0.3	0.3	0.7	0.6	0.5	-0.6	-0.4	-0.4	0.9	0.6
Locomotion velocity, hab. session 2	0.2	0.3	0.7	0.7	0.5	-0.5	-0.3	-0.3	0.8	0.6
Novel to familiar place preference ratio	0.1	0.2	0.3	0.2	0.3	-0.5	-0.5	-0.5	0.5	0.3
Novelty place preference	0.1	0.1	0.2	0.1	0.1	-0.3	-0.4	-0.4	0.4	0.2
Time in novel zone, NPP test	0.1	0.1	0.2	0.1	0.2	-0.4	-0.5	-0.5	0.4	0.2
Total zone transitions, NPP test	0.6	0.9	2.2	1.5	1.0	-0.6	-0.5	-0.5	0.9	1.2
Total locomotion distance, NPP test	2.3	3.2	3.7	1.8	1.9	-1.7	-1.7	-1.7	1.8	1.9
Locomotion velocity, NPP test	2.1	3.0	3.6	1.8	1.8	-1.6	-1.6	-1.6	1.7	1.9
Intraocular pressure	2.9	4.8	5.9	2.4	2.4	-2.1	-1.8	-1.8	2.4	2.3
Delta distance traveled before/after self-admin	1.6	1.8	2.5	-0.4	-1.4	1.5	1.6	1.6	-1.3	-1.3
Delta ambulatory time before/after self-admin	1.0	1.8	2.6	-0.1	-1.4	1.6	1.6	1.6	-1.3	-1.2
Parametrial fat weight	0.1	0.2	0.5	-0.3	-0.4	0.6	0.4	0.4	-0.7	-0.2
Pavlov. Cond. lever latency	0.2	0.2	0.5	0.3	0.4	-0.5	-0.7	-0.7	0.1	0.4
Pavlov. Cond. magazine entry latency	3.6	4.6	6.0	-1.6	-2.1	2.3	2.4	2.4	-1.9	-2.0
Pavlov. Cond. change in total contacts	0.9	0.9	1.4	-0.5	-1.0	1.1	1.2	1.2	-0.6	-1.0
Pavlov. Cond. index score	1.9	2.4	3.3	-1.3	-1.6	1.7	1.8	1.8	-1.2	-1.5
Pavlov. Cond. latency score	1.4	1.8	2.4	-1.1	-1.3	1.4	1.6	1.6	-1.0	-1.3
Pavlov. Cond. lever contacts	0.1	0.1	0.2	-0.1	-0.1	0.2	0.4	0.4	0.4	-0.2
Pavlov. Cond. magazine entry number	6.7	8.5	10.3	2.4	3.0	-3.2	-3.2	-3.2	2.5	2.8
Pavlov. Cond. intertrial magazine entries	0.8	1.0	1.4	0.9	0.9	-1.1	-0.9	-0.9	1.1	1.2
Pavlov. Cond. lever-magazine prob. diff.	1.6	2.0	2.8	-1.1	-1.4	1.5	1.7	1.7	-1.0	-1.3
Pavlov. Cond. response bias	3.5	4.4	5.7	-1.6	-2.1	2.3	2.4	2.4	-1.7	-1.9
Pavlov. Cond. lever latency	0.1	0.1	0.6	-0.8	-0.1	-0.3	0.0	0.0	-0.1	-0.3
Pavlov. Cond. magazine entry latency	2.3	3.3	5.5	-1.3	-2.0	2.4	1.6	1.6	-1.9	-1.8
Pavlov. Cond. change in total contacts	0.0	0.1	0.3	0.6	0.2	0.1	-0.1	-0.1	0.1	0.3
Pavlov. Cond. index score	0.5	0.7	1.7	-0.3	-1.0	1.3	0.7	0.7	-1.0	-0.7
Pavlov. Cond. latency score	0.7	1.2	2.5	-0.6	-1.2	1.6	0.9	0.9	-1.2	-0.9
Pavlov. Cond. lever contacts	0.2	0.2	1.1	1.1	0.2	0.2	-0.3	-0.3	0.2	0.6
Pavlov. Cond. magazine entry number	1.5	1.9	3.0	1.1	1.4	-1.7	-1.1	-1.1	1.7	1.4
Pavlov. Cond. intertrial magazine entries	0.3	0.7	1.9	0.2	0.9	-1.4	-0.5	-0.5	1.2	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.8	2.0	-0.3	-1.0	1.4	0.6	0.6	-1.0	-0.7
Pavlov. Cond. response bias	0.1	0.1	0.3	0.6	-0.1	0.5	0.0	0.0	-0.3	0.0
Time in closed arm before self-admin	0.5	0.8	1.3	1.1	1.0	-0.9	-0.7	-0.7	0.8	1.1
Time in closed arm after self-admin	1.7	1.9	2.5	1.1	1.6	-1.6	-1.4	-1.4	1.3	1.3
Time in open arm before self-admin	2.1	2.6	3.1	-1.3	-1.6	1.7	1.7	1.7	-1.4	-1.8
Time in open arm after self-admin	3.1	3.4	5.6	-0.8	-2.2	2.4	2.0	2.0	-1.8	-1.4
Bone: periosteal estimation	0.1	0.1	0.4	-0.4	0.1	-0.2	-0.6	-0.6	-0.2	-0.3
Bone: periosteal perimeter	0.1	0.2	0.5	-0.4	0.1	-0.4	-0.7	-0.7	-0.2	-0.5
Bone: post-yield work	0.2	0.4	0.6	-0.3	-0.6	0.7	0.7	0.7	-0.5	-0.8
Progressive ratio test 1 active lever presses	0.2	0.3	1.3	-1.1	-0.6	0.2	0.2	0.2	-0.4	-0.3
Progressive ratio test 1 breakpoint	0.1	0.2	1.3	-1.1	-0.5	0.1	0.1	0.1	-0.3	-0.2
Progressive ratio test 1 inactive lever presses	0.1	0.3	1.5	-1.2	-0.4	0.0	-0.1	-0.1	-0.1	-0.3
Progressive ratio test 2 active lever presses	1.1	1.6	2.5	-1.6	-1.5	1.0	1.0	1.0	-1.5	-1.1
Progressive ratio test 2 breakpoint	1.0	1.3	2.1	-1.4	-1.4	0.9	0.9	0.9	-1.4	-1.0
Progressive ratio test 2 inactive lever presses	0.4	1.2	3.1	-1.8	-1.1	0.6	0.8	0.8	-1.0	-1.1
Incentive Sensitization - Responses	1.1	3.0	4.9	-1.2	-1.9	1.7	1.6	1.6	-2.2	-1.6
Incentive Sensitization - Breakpoint	1.2	2.8	4.7	-1.2	-1.8	1.6	1.6	1.6	-2.2	-1.5
Sum of active levers in priming session hrs 5-6	0.1	0.1	0.3	0.5	0.1	0.2	0.2	0.2	-0.6	-0.0
Progressive ratio	0.1	0.3	0.6	-0.1	-0.7	0.8	0.6	0.6	-0.6	-0.1
Food seeking constrained by brief footshock	1.1	1.3	2.6	-0.5	-0.9	1.3	1.4	1.4	-1.6	-0.6
Seeking ratio, punishment vs. effort	0.0	0.1	0.2	-0.2	0.1	0.1	0.3	0.3	-0.4	-0.3
Retroperitoneal fat weight	0.3	1.5	2.6	-1.3	-1.3	1.4	1.0	1.0	-1.6	-0.5
Reaction time number correct	0.3	1.1	2.0	0.6	1.1	-0.8	-0.9	-0.9	1.4	1.3
Reaction time mean minus median	0.1	0.7	1.3	1.1	0.8	-0.8	-0.7	-0.7	0.3	1.1
Reaction time mean minus median AUC	0.0	0.2	0.5	0.6	0.3	-0.4	-0.4	-0.4	-0.3	0.7
Reaction time num false alarms	0.2	0.3	0.5	-0.7	-0.5	0.4	0.6	0.6	-0.4	-0.7
Reaction time num false alarms AUC	0.3	0.6	1.4	-1.2	-0.7	0.5	0.7	0.7	-0.7	-0.8
Reaction time trials correct on left	0.3	1.1	2.0	0.6	1.1	-0.8	-0.9	-0.9	1.4	1.3
Reaction time trials on left	0.4	1.4	2.4	0.8	1.3	-1.0	-1.1	-1.1	1.6	1.4
Reaction time mean	1.5	3.4	5.2	2.3	1.6	-1.6	-2.0	-2.0	1.4	2.0
Reaction time mean AUC	1.1	2.6	4.0	2.0	1.4	-1.5	-1.7	-1.7	1.2	1.7
Median of all reaction times	1.7	2.6	3.7	1.9	1.4	-1.4	-1.8	-1.8	1.2	1.6
Reaction time omissions	2.8	4.6	6.2	2.4	1.8	-1.7	-2.5	-2.5	1.7	2.3
Reaction time false alarm rate	1.2	1.6	2.1	-1.3	-1.2	1.0	1.2	1.2	-1.4	-1.4
Reaction time premature initiation rate	3.1	4.9	6.7	-2.6	-2.4	1.9	2.0	2.0	-2.4	-1.9
Reaction time premature initiations	0.5	1.5	3.3	-1.8	-1.4	1.1	1.1	1.1	-1.2	-0.8
Std. dev. reaction times	0.8	2.5	4.3	2.1	1.4	-1.4	-1.6	-1.6	1.0	1.9
Reaction time trials completed	0.4	1.4	2.4	0.8	1.3	-1.0	-1.1	-1.1	1.6	1.4
Reaction time trials AUC	0.4	1.3	2.3	0.8	1.2	-0.9	-1.1	-1.1	1.5	1.3
Run reversals in cocaine runway, females	0.5	0.5	0.8	0.5	0.8	-0.9	-0.7	-0.7	0.8	0.6
Run reversals in cocaine runway, males	0.4	0.5	0.8	0.5	0.9	-0.8	-0.7	-0.7	0.3	0.5
Latency to leave start box in cocaine runway	0.3	0.4	0.8	0.3	0.9	-0.8	-0.5	-0.5	0.7	0.6
Latency to leave start box in cocaine runway, F	0.0	0.1	0.2	-0.4	0.1	-0.1	-0.0	-0.0	0.4	-0.2
Latency to leave start box in cocaine runway, M	0.9	0.8	1.4	1.0	1.2	-1.0	-0.7	-0.7	0.6	1.1
Std. dev. time between licks in bursts	0.9	1.6	1.9	-1.0	-1.2	1.3	1.4	1.4	-1.2	-1.3
Total sessions with >9 infusions	0.3	0.4	0.9	-1.0	-0.7	0.5	0.4	0.4	-0.7	-0.3
Short access day 1 total inactive lever presses	0.1	0.1	0.5	-0.7	-0.3	0.2	0.2	0.2	-0.3	-0.1
Short access day 10 total inactive lever presses	0.1	0.5	0.8	0.4	0.8	-0.8	-0.7	-0.7	0.9	0.6
Short access day 1 total infusions	0.1	0.2	0.6	-0.8	-0.4	0.1	0.2	0.2	-0.3	-0.3
Short access day 10 total infusions	0.1	0.2	0.6	-0.8	0.1	-0.5	-0.6	-0.6	-0.0	0.2
Short access total infusions	0.2	0.3	1.1	-1.1	-0.6	0.3	0.3	0.3	-0.5	-0.3
Short access day 1 locomotion	0.1	0.2	1.0	-1.0	-0.4	-0.1	-0.1	-0.1	-0.2	-0.1
Short access day 10 total locomotion	1.6	6.6	8.1	1.6	2.6	-2.6	-2.8	-2.8	2.4	2.8
Short access total locomotion	0.8	1.2	1.7	-0.1	1.0	-1.3	-1.3	-1.3	1.0	1.2
One hour access (0.3 mA shock)	0.6	0.7	2.3	-1.5	-0.9	0.4	0.5	0.5	-1.0	-0.7
Compulsive drug intake	0.1	0.1	0.3	0.4	-0.2	0.3	0.5	0.5	-0.3	-0.2
One hour access (shock baseline)	0.2	0.4	1.9	-1.4	-0.5	-0.0	-0.1	-0.1	-0.7	-0.4
Social response proportion	9.0	11.4	12.3	3.2	3.5	-3.4	-3.4	-3.4	3.5	3.1
Social responses	2.6	3.4	5.2	1.6	1.8	-1.8	-1.9	-1.9	2.3	1.6
Social time	0.7	1.1	2.6	1.6	1.0	-0.7	-0.9	-0.9	1.1	0.9
Soleus weight	0.5	1.4	4.4	-2.1	-0.9	0.7	0.9	0.9	-0.8	-1.3
Bone: stiffness	0.2	0.3	0.7	-0.2	-0.7	0.8	0.2	0.2	-0.9	-0.5
Tibialis anterior weight	2.7	9.2	10.4	2.9	3.2	-3.0	-2.9	-2.9	3.1	3.2
Time to tail flick, vehicle, before self-admin	0.1	0.2	0.9	-0.9	-0.3	0.0	0.0	0.0	-0.0	-0.6
Time to tail flick, vehicle, after self-admin	0.2	0.4	1.1	-1.0	-0.3	0.3	0.0	0.0	-1.1	-0.8
Time to tail flick, test, before self-admin	0.7	0.8	1.3	0.5	0.7	-0.9	-1.1	-1.1	0.3	1.2
Time to tail flick, test, after self-admin	1.2	1.2	2.5	1.6	1.0	-0.8	-1.0	-1.0	0.9	1.3
Delta time to tail flick, vehicle, before/after SA	0.0	0.0	0.1	0.1	0.1	0.0	-0.2	-0.2	-0.3	-0.0
Delta time to tail flick, test, before/after SA	0.1	0.1	0.5	0.5	0.4	-0.1	0.1	0.1	0.7	0.1
Tibia length	0.1	0.3	0.7	-0.6	-0.4	0.5	0.3	0.3	-0.8	-0.8
Ambulatory time before self-admin	0.0	0.1	0.4	-0.5	-0.4	0.2	0.2	0.2	-0.6	-0.1
Ambulatory time after self-admin	0.6	1.0	1.3	-0.1	-1.1	1.1	1.1	1.1	-1.1	-0.8
Bone: tissue strength	0.2	0.2	0.4	0.6	0.2	-0.2	-0.5	-0.5	0.1	-0.3
Total heroin consumption	0.7	0.8	1.6	1.3	0.9	-1.0	-0.9	-0.9	0.4	0.6
Bone: trabecular number	0.0	0.1	0.1	0.3	-0.2	0.3	0.4	0.4	-0.1	-0.2
Bone: trabecular spacing	0.9	1.4	1.8	1.0	1.2	-1.1	-1.3	-1.3	0.8	1.2
Bone: trabecular thickness	1.8	2.5	3.1	1.7	1.8	-1.5	-1.4	-1.4	1.7	1.4
Bone: trabecular tissue density	0.3	0.5	1.3	1.2	0.6	-0.1	-0.5	-0.5	0.5	0.9
Water consumed over 24 hours	1.0	2.0	3.6	-0.7	-1.7	1.9	1.1	1.1	-1.9	-0.8
Number of responses in last shaping day	0.3	0.3	1.0	-1.0	-0.5	0.6	0.6	0.6	-0.2	-0.2