Hub : Genes

LOC102550580

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R² and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

#	Tissue	Modality	RNA phenotype	h2	h2 SE	h2 P	xQTL R2	BLUP R2	ENET R2	LASSO R2	xQTL P	BLUP P	ENET P	LASSO P
1	Adipose	alternative polyA	XR_005490722.1	0.03	0.02	1.0e-04	0.03	0.02	0.03	0.02	1.9e-04	6.6e-03	2.4e-04	4.8e-03
2	Adipose	alternative polyA	XR_005490722.1	0.06	0.04	1.6e-07	0.07	0.05	0.04	0.06	7.7e-08	1.4e-06	1.5e-05	1.3e-07
3	Adipose	isoform ratio	XR_005490722.1	0.06	0.04	2.5e-08	0.06	0.04	0.04	0.05	9.8e-07	1.8e-05	3.2e-05	1.3e-06
4	Adipose	intron excision ratio	chr10_81314588_81316216	0.02	0.02	2.9e-03	0.02	0.02	0.02	0.02	1.0e-03	3.7e-03	2.0e-03	1.5e-03
5	Adipose	gene expression	LOC102550580	0.07	0.05	3.9e-10	0.06	0.01	0.06	0.02	9.0e-08	1.9e-02	1.3e-07	3.8e-03
6	Adipose	intron excision ratio	chr10_81309857_81313038	0.03	0.03	7.4e-03	0.02	0.01	0.02	0.01	1.7e-03	6.4e-02	3.9e-03	4.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bone: apparent density	1.2	2.1	2.9	-1.4	-1.4	-1.4	1.2	1.4	-1.7
Area under the delay curve	0.1	0.1	0.3	-0.0	-0.0	-0.0	-0.1	-0.6	0.3
BMI with tail	15.8	51.1	55.7	-7.2	-7.2	-7.2	7.1	7.5	-6.6
BMI without tail	0.8	1.7	2.8	-1.1	-1.1	-1.1	1.1	1.5	-1.7
Body weight	0.7	2.9	3.2	-1.8	-1.8	-1.8	1.7	1.6	-1.6
Weight adjusted by age	0.3	0.3	1.3	0.2	0.2	0.2	-0.3	-0.6	1.1
Bone surface	0.4	0.6	1.0	-0.8	-0.8	-0.8	0.6	0.7	-1.0
Bone volume	1.0	1.7	2.5	-1.3	-1.3	-1.3	1.0	1.2	-1.6
Breakpoint value in progressive ratio session	4.1	4.5	4.9	2.2	2.2	2.2	-2.1	-1.8	2.1
Number of licking bursts	0.6	0.7	1.0	1.0	1.0	1.0	-1.0	-0.4	0.4
Context. condit. distance diff. score	0.9	1.0	1.4	-1.2	-1.2	-1.2	1.2	0.7	-0.4
Locomotion velocity, session 1	0.2	0.2	0.5	0.2	0.2	0.2	-0.2	0.7	-0.7
Locomotion distance, session 1	4.3	5.5	6.9	2.6	2.6	2.6	-2.6	-1.7	1.7
Locomotion velocity, session 2	1.1	1.3	1.5	1.1	1.1	1.1	-1.2	-1.1	1.0
Locomotion distance, session 2	5.5	7.7	10.2	3.1	3.1	3.1	-3.2	-1.8	1.9
Locomotion velocity, session 3	0.3	0.3	0.6	-0.6	-0.6	-0.6	0.7	0.0	0.0
Locomotion distance, session 3	1.7	1.9	3.3	1.1	1.1	1.1	-1.2	-1.7	1.8
Stereotopy head waving bouts, day 3	4.1	4.9	6.9	-2.0	-2.0	-2.0	2.2	2.6	-2.4
Stereotopy head waving duration, day 3	3.2	3.9	4.7	-1.9	-1.9	-1.9	2.0	2.2	-2.1
Locomotion velocity, session 7	1.1	1.2	1.6	1.1	1.1	1.1	-1.2	-0.8	1.2
Locomotion distance, session 7	5.9	7.5	9.4	2.9	2.9	2.9	-3.1	-2.2	2.5
Stereotopy head waving bouts, day 7	0.4	0.5	0.8	-0.6	-0.6	-0.6	0.7	0.6	-0.9
Stereotopy head waving duration, day 7	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.6	0.4	-0.6
Locomotion velocity, session 8	0.7	0.8	1.0	-1.0	-1.0	-1.0	1.0	0.9	-0.3
Locomotion distance, session 8	0.5	0.7	0.9	0.8	0.8	0.8	-0.9	-0.8	1.0
Degree of sensitization distance	0.2	0.2	0.3	0.4	0.4	0.4	-0.6	0.3	0.0
Degree of sensitization stereotypy	0.2	0.2	0.2	0.5	0.5	0.5	-0.4	-0.4	0.2
Conditioned locomotion	2.2	2.6	3.4	-1.8	-1.8	-1.8	1.7	1.2	-1.1
Cocaine response after cond. corrected	5.7	6.4	6.7	-2.6	-2.6	-2.6	2.6	2.5	-2.4
Cocaine response after cond. not corrected	3.2	3.5	3.9	-1.9	-1.9	-1.9	2.0	1.8	-1.8
Cocaine response before conditioning	2.7	3.3	3.5	1.9	1.9	1.9	-1.8	-1.8	1.6
Saline control response	0.1	0.2	0.2	-0.4	-0.4	-0.4	0.4	-0.3	0.3
Bone: connectivity density	0.2	0.4	0.5	-0.7	-0.7	-0.7	0.5	0.4	-0.5
Bone: cortical apparent density	5.6	7.4	10.3	2.6	2.6	2.6	-2.5	-2.6	3.2
Bone: cortical area	0.3	0.4	0.7	-0.8	-0.8	-0.8	0.6	-0.1	-0.4
Bone: cortical porosity	0.3	0.3	0.6	-0.5	-0.5	-0.5	0.5	0.4	-0.8
Bone: cortical porosity	0.2	0.2	0.5	-0.4	-0.4	-0.4	0.3	0.4	-0.7
Bone: cortical thickness	0.2	0.3	0.3	-0.5	-0.5	-0.5	0.4	-0.5	0.6
Bone: cortical thickness	0.7	0.8	1.7	0.6	0.6	0.6	-0.7	-1.3	1.1
Bone: cortical tissue density	6.1	8.1	10.9	2.8	2.8	2.8	-2.7	-2.7	3.3
Condit. Reinf. active minus inactive responses	0.8	0.9	1.5	1.1	1.1	1.1	-1.2	-0.7	0.3
Condit. Reinf. active-inactive response ratio	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.0	0.1	-0.5
Condit. Reinf. active responses	0.9	1.1	1.7	1.3	1.3	1.3	-1.3	-0.6	0.2
Condit. Reinf. inactive responses	0.9	1.1	1.6	1.2	1.2	1.2	-1.0	-0.6	0.6
Incentive salience index mean	1.5	1.9	2.6	1.5	1.5	1.5	-1.6	-1.1	0.6
Condit. Reinf. lever presses	2.1	2.9	3.5	1.9	1.9	1.9	-1.8	-1.5	1.1
Condit. Reinf. active minus inactive responses	0.1	0.2	0.2	0.4	0.4	0.4	-0.4	0.2	-0.4
Condit. Reinf. active-inactive response ratio	0.2	0.2	0.4	0.5	0.5	0.5	-0.4	0.5	-0.6
Condit. Reinf. active responses	0.1	0.1	0.1	0.4	0.4	0.4	-0.3	-0.2	-0.1
Condit. Reinf. inactive responses	0.1	0.1	0.2	-0.1	-0.1	-0.1	0.1	-0.5	0.4
Condit. Reinf. lever presses	0.5	0.7	1.2	0.7	0.7	0.7	-0.5	-1.1	1.1
Condit. Reinf. lever reinforcers received	0.1	0.1	0.2	0.4	0.4	0.4	-0.4	-0.3	0.2
Conditioned reinforcement - actives	0.5	0.5	0.9	0.7	0.7	0.7	-0.5	0.3	-1.0
Conditioned reinforcement - inactives	0.1	0.1	0.1	0.4	0.4	0.4	-0.3	0.2	0.2
Conditioned locomotion	0.7	0.9	4.0	-0.4	-0.4	-0.4	0.5	0.7	-2.0
Patch foraging indifference point 0 sec	1.4	2.2	3.2	-1.7	-1.7	-1.7	1.8	0.7	-1.1
Patch foraging indifference point AUC	0.1	0.1	0.3	0.1	0.1	0.1	-0.1	-0.6	0.3
Delay disc. indifference point, 0s delay	0.3	0.3	0.8	-0.4	-0.4	-0.4	0.2	-0.9	0.9
Delay disc. indifference point, 16s delay	1.0	1.0	1.4	-1.2	-1.2	-1.2	1.1	0.5	-0.6
Delay disc. indifference point, 2s delay	0.0	0.0	0.0	-0.0	-0.0	-0.0	-0.1	-0.2	0.2
Delay disc. indifference point, 24s delay	0.8	0.8	1.2	0.9	0.9	0.9	-1.1	-0.9	0.6
Delay disc. indifference point, 4s delay	1.3	1.4	2.8	1.0	1.0	1.0	-1.1	-1.3	1.7
Delay disc. indifference point, 8s delay	0.2	0.2	0.6	0.3	0.3	0.3	-0.4	-0.8	0.3
Indifference point function ln k	0.0	0.1	0.1	0.2	0.2	0.2	-0.3	-0.2	0.2
Indifference point function log k	0.0	0.1	0.1	0.2	0.2	0.2	-0.3	-0.2	0.2
Patch foraging total patch changes 0 sec	1.5	2.5	3.6	-1.8	-1.8	-1.8	1.9	0.7	-1.1
Patch foraging total patch changes 12 sec	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.5	-0.1	-0.3
Patch foraging total patch changes 18 sec	2.4	3.0	4.2	-2.0	-2.0	-2.0	2.1	0.8	-1.4
Patch foraging total patch changes 24 sec	1.4	1.7	2.5	-1.3	-1.3	-1.3	1.4	0.8	-1.6
Patch foraging total patch changes 6 sec	1.0	1.5	2.2	-1.3	-1.3	-1.3	1.5	0.6	-0.9
Patch foraging time to switch 0 sec	0.0	0.0	0.1	0.1	0.1	0.1	-0.2	-0.1	-0.2
Patch foraging water rate 0 sec	1.3	2.2	2.8	-1.5	-1.5	-1.5	1.7	1.4	-1.2
Patch foraging water rate 12 sec	0.2	0.3	0.6	-0.6	-0.6	-0.6	0.8	0.3	0.2
Patch foraging water rate 18 sec	0.0	0.1	0.3	0.1	0.1	0.1	0.0	-0.2	0.6
Patch foraging water rate 24 sec	1.2	1.7	2.0	-1.3	-1.3	-1.3	1.4	1.4	-1.0
Patch foraging water rate 6 sec	0.0	0.0	0.2	-0.0	-0.0	-0.0	0.2	0.4	-0.2
Seeking ratio, delayed vs. immediate footshock	1.9	2.2	3.0	-1.7	-1.7	-1.7	1.6	1.2	-0.6
Distance traveled before self-admin	2.3	2.4	3.1	1.8	1.8	1.8	-1.7	-1.5	0.6
Distance traveled after self-admin	0.2	0.2	0.9	-0.2	-0.2	-0.2	0.4	-0.3	-1.0
Extensor digitorum longus weight	0.6	2.5	3.6	-1.9	-1.9	-1.9	1.8	0.8	-0.5
Bone: elastic displacement	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.1	0.3	-0.3
Bone: elastic work	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.2	-0.1	0.0
Bone: endosteal estimation	0.1	0.2	1.0	-0.2	-0.2	-0.2	0.2	0.3	-1.0
Bone: endosteal perimeter	0.3	0.5	1.6	-0.6	-0.6	-0.6	0.5	0.4	-1.3
Epididymis fat weight	0.0	0.0	0.0	-0.1	-0.1	-0.1	0.1	0.1	-0.1
Delta time in closed arm before/after self-admin	0.1	0.1	0.2	-0.3	-0.3	-0.3	0.2	0.5	0.4
Delta time in open arm before/after self-admin	0.1	0.1	0.4	-0.2	-0.2	-0.2	0.1	-0.6	0.4
Diff in mean of infusions in LGA sessions	1.8	2.0	2.7	1.6	1.6	1.6	-1.5	-0.9	0.6
Delay discount exponential model param	0.1	0.1	0.4	-0.2	-0.2	-0.2	0.3	0.6	-0.4
Extinction: sum of active levers before priming	1.3	1.3	1.7	1.1	1.1	1.1	-1.2	-1.3	1.2
Active lever presses in extinction session 6	0.1	0.1	0.3	-0.0	-0.0	-0.0	-0.0	-0.1	-0.6
Bone: final force	0.1	0.1	0.5	-0.3	-0.3	-0.3	0.2	0.0	-0.7
Bone: final moment	0.2	0.3	0.6	-0.5	-0.5	-0.5	0.4	0.2	-0.8
Food consumed during 24 hour testing period	2.1	2.6	3.1	1.6	1.6	1.6	-1.6	-1.8	1.4
Glucose	0.8	1.2	1.5	-1.1	-1.1	-1.1	1.2	1.1	-0.9
Heart weight	1.3	1.9	4.2	-1.1	-1.1	-1.1	1.0	2.1	-1.7
Delay discount hyperbolic model param	0.2	0.2	0.4	-0.2	-0.2	-0.2	0.4	0.6	-0.6
Intermittent access intake day 1-15 change	1.8	1.8	4.0	-1.1	-1.1	-1.1	1.0	1.5	-2.0
Intermittent access intake escalation	1.3	1.3	3.7	-0.8	-0.8	-0.8	0.7	1.2	-1.9
Intermittent access intake escalation 2	1.5	1.4	3.1	-1.0	-1.0	-1.0	1.0	1.2	-1.7
Intermitt. access day 1 inactive lever presses	0.0	0.0	0.1	-0.0	-0.0	-0.0	-0.1	0.1	0.3
Intermitt. access day 15 inactive lever presses	1.5	1.6	2.1	-1.4	-1.4	-1.4	1.4	0.9	-0.8
Intermitt. access escalation Index	0.3	0.3	1.1	0.3	0.3	0.3	-0.3	0.2	-1.1
Intermittent access day 1 total infusions	1.2	1.4	1.7	1.3	1.3	1.3	-1.2	-0.9	1.0
Intermittent access day 15 total infusions	0.4	0.4	0.6	0.8	0.8	0.8	-0.7	-0.2	-0.4
Intermittent access terminal intake (last 3 days)	0.2	0.2	0.2	0.5	0.5	0.5	-0.4	0.1	-0.4
Intermittent access total infusions	0.2	0.3	0.4	0.7	0.7	0.7	-0.6	-0.0	0.1
Intermittent access day 1 locomotion	2.1	2.2	3.0	1.7	1.7	1.7	-1.7	-1.0	0.7
Intermittent access day 15 total locomotion	0.6	0.6	0.8	0.9	0.9	0.9	-0.9	-0.1	-0.6
Intermittent access total locomotion	0.7	0.8	1.1	1.1	1.1	1.1	-1.0	-0.2	-0.7
Intermittent access standard deviation	1.7	1.8	4.2	-1.0	-1.0	-1.0	0.9	1.6	-2.0
Left kidney weight	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.1	0.1
Right kidney weight	0.5	1.3	1.7	-1.1	-1.1	-1.1	1.3	1.1	-1.0
Cocaine induced anxiety	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	0.3	-0.3
Post-drug Anxiety	0.8	0.9	1.2	1.1	1.1	1.1	-1.1	-0.4	0.7
Baseline Anxiety	0.0	0.0	0.0	0.1	0.1	0.1	-0.1	0.2	0.1
Tail length	15.6	47.3	50.3	7.1	7.1	7.1	-7.0	-7.0	5.9
Length with tail	8.0	29.5	32.6	5.4	5.4	5.4	-5.5	-5.7	5.0
Length without tail	0.0	0.1	0.3	0.0	0.0	0.0	-0.1	-0.2	0.5
Times rat made contact with spout	0.6	0.7	0.9	1.0	1.0	1.0	-1.0	-0.7	0.4
Lifetime Intake	0.3	0.3	0.5	0.7	0.7	0.7	-0.6	-0.4	0.3
Liver weight, left	0.9	1.4	1.8	1.2	1.2	1.2	-1.3	-1.1	0.9
Liver weight, right	0.6	1.0	1.4	0.9	0.9	0.9	-1.2	-1.1	0.9
Locomotor activity	0.1	0.2	1.0	-0.3	-0.3	-0.3	0.3	0.3	-1.0
Locomotor testing distance	0.4	0.7	1.6	-0.7	-0.7	-0.7	0.8	0.5	-1.3
Locomotor testing rearing	0.1	0.1	0.2	-0.4	-0.4	-0.4	0.4	-0.2	-0.4
Locomotion in novel chamber	0.2	0.3	1.0	0.4	0.4	0.4	-0.4	0.2	1.0
Locomotion in novel chamber post-restriction	1.5	1.8	2.0	-1.4	-1.4	-1.4	1.1	1.4	-1.3
Fecal boli incidents, locomotor time 1	3.0	3.3	5.3	-1.7	-1.7	-1.7	1.5	2.3	-2.0
Change in fecal boli incidents, locomotor task	2.5	2.3	3.2	1.5	1.5	1.5	-1.3	-1.6	1.8
Time >=10cm from walls, locomotor time 1	0.2	0.2	0.8	0.1	0.1	0.1	0.0	-0.9	0.6
Bouts of movement, locomotor time 1	0.1	0.1	0.1	-0.4	-0.4	-0.4	0.3	0.4	-0.2
Total resting periods, locomotor time 1	0.4	0.4	0.5	-0.7	-0.7	-0.7	0.6	0.6	-0.4
Rest time, locomotor task time 1	0.2	0.2	0.4	-0.4	-0.4	-0.4	0.3	0.6	-0.6
Distance moved, locomotor task time 1	2.1	2.3	2.7	1.7	1.7	1.7	-1.6	-1.2	1.3
Vertical activity count, locomotor time 1	0.6	0.7	0.8	0.8	0.8	0.8	-0.7	-0.8	0.9
Time >=10cm from walls, locomotor time 2	0.4	0.4	0.9	0.6	0.6	0.6	-0.6	-0.6	0.9
Bouts of movement, locomotor time 2	0.1	0.1	0.3	-0.4	-0.4	-0.4	0.3	0.5	-0.4
Total resting periods, locomotor time 2	0.2	0.2	0.4	-0.5	-0.5	-0.5	0.4	0.7	-0.4
Rest time, locomotor task time 2	0.6	0.7	1.2	0.8	0.8	0.8	-0.7	-0.7	1.1
Distance moved, locomotor task time 2	0.2	0.2	0.2	0.5	0.5	0.5	-0.5	-0.1	0.5
Vertical activity count, locomotor time 2	0.0	0.0	0.0	0.2	0.2	0.2	-0.2	-0.0	0.1
Light reinforcement 1	0.1	0.1	0.4	-0.1	-0.1	-0.1	0.2	0.4	-0.6
Light reinforcement 2	0.2	0.3	0.5	0.7	0.7	0.7	-0.7	-0.3	-0.2
Bone: marrow area	0.1	0.1	0.7	-0.1	-0.1	-0.1	0.1	0.1	-0.9
Bone: maximum diameter	0.3	0.5	1.4	-0.7	-0.7	-0.7	0.6	0.3	-1.2
Bone: maximum force	0.5	0.8	1.2	-1.0	-1.0	-1.0	0.9	0.4	-1.1
Bone: maximum moment	0.6	1.0	1.2	-1.1	-1.1	-1.1	1.0	0.5	-1.1
Mean time between licks in bursts	0.6	0.9	1.2	-1.1	-1.1	-1.1	1.1	0.6	-0.2
Mean num. licks in bursts	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.1	-0.4	0.2
Cd content in liver	0.2	0.2	0.7	0.3	0.3	0.3	-0.3	-0.5	0.8
Co content in liver	0.1	0.1	0.6	-0.0	-0.0	-0.0	0.1	0.8	-0.2
Cu content in liver	8.6	10.4	14.2	3.7	3.7	3.7	-3.8	-2.1	1.4
Fe content in liver	1.8	2.1	2.5	1.5	1.5	1.5	-1.6	-1.5	1.1
K content in liver	0.7	0.7	1.2	0.9	0.9	0.9	-1.1	0.5	-0.6
Mg content in liver	2.1	2.1	3.7	1.6	1.6	1.6	-1.9	-0.7	0.6
Mn content in liver	3.4	3.9	4.2	2.0	2.0	2.0	-2.1	-2.1	1.7
Na content in liver	0.6	0.6	1.1	0.7	0.7	0.7	-0.9	0.4	-1.1
Rb content in liver	0.4	0.5	1.0	1.0	1.0	1.0	-0.5	0.0	-0.0
Se content in liver	0.3	0.3	0.5	-0.6	-0.6	-0.6	0.3	0.7	-0.7
Sr content in liver	1.2	1.1	2.8	0.5	0.5	0.5	-0.7	-1.7	1.6
Zn content in liver	0.1	0.1	0.2	0.3	0.3	0.3	-0.5	0.4	-0.2
Bone: minimum diameter	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.0	-0.2	-0.4
Time in familiar zone, hab. session 1	0.1	0.1	0.6	0.2	0.2	0.2	-0.2	-0.3	0.8
Time in novel zone, hab. session 1	2.3	2.3	3.2	-1.3	-1.3	-1.3	1.4	1.7	-1.8
Total zone transitions, hab. session 1	6.5	9.1	10.3	3.1	3.1	3.1	-3.2	-2.7	3.0
Total locomotion distance, hab. session 1	3.5	5.0	6.6	2.4	2.4	2.4	-2.6	-1.6	1.9
Locomotion velocity, hab. session 1	4.5	6.3	8.0	2.7	2.7	2.7	-2.8	-2.0	2.2
Time in familiar zone, hab. session 2	1.0	1.0	1.4	-1.1	-1.1	-1.1	1.2	1.0	-0.6
Time in novel zone, hab. session 2	0.1	0.1	0.2	0.3	0.3	0.3	-0.4	-0.3	0.2
Total zone transitions, hab. session 2	4.0	5.1	6.7	2.5	2.5	2.5	-2.6	-1.6	1.5
Total locomotion distance, hab. session 2	0.9	1.2	1.9	1.3	1.3	1.3	-1.4	-0.1	0.0
Locomotion velocity, hab. session 2	1.1	1.4	2.2	1.4	1.4	1.4	-1.5	-0.3	0.1
Novel to familiar place preference ratio	0.3	0.3	1.1	0.4	0.4	0.4	-0.5	-0.6	1.0
Novelty place preference	0.3	0.3	1.3	0.2	0.2	0.2	-0.4	-0.6	1.1
Time in novel zone, NPP test	0.2	0.2	1.0	0.1	0.1	0.1	-0.2	-0.4	1.0
Total zone transitions, NPP test	5.2	7.3	8.6	2.9	2.9	2.9	-2.9	-2.4	2.2
Total locomotion distance, NPP test	1.5	2.1	3.0	1.6	1.6	1.6	-1.7	-1.0	0.9
Locomotion velocity, NPP test	2.0	2.9	4.0	1.8	1.8	1.8	-2.0	-1.3	1.2
Intraocular pressure	1.5	2.2	4.7	1.2	1.2	1.2	-1.3	-2.2	1.4
Delta distance traveled before/after self-admin	2.6	2.8	3.6	-1.8	-1.8	-1.8	1.9	1.1	-1.3
Delta ambulatory time before/after self-admin	2.6	2.9	3.3	-1.8	-1.8	-1.8	1.8	1.5	-1.5
Parametrial fat weight	0.1	0.3	0.4	0.6	0.6	0.6	-0.6	-0.3	-0.1
Pavlov. Cond. lever latency	1.4	1.8	1.9	-1.3	-1.3	-1.3	1.4	1.4	-1.3
Pavlov. Cond. magazine entry latency	0.1	0.2	0.2	0.5	0.5	0.5	-0.5	-0.3	0.1
Pavlov. Cond. change in total contacts	3.5	3.7	4.3	2.0	2.0	2.0	-2.1	-1.8	1.6
Pavlov. Cond. index score	0.8	1.0	1.2	1.1	1.1	1.1	-1.1	-1.0	0.8
Pavlov. Cond. latency score	0.9	1.1	1.2	1.1	1.1	1.1	-1.1	-1.0	0.9
Pavlov. Cond. lever contacts	2.2	2.6	2.7	1.7	1.7	1.7	-1.6	-1.6	1.5
Pavlov. Cond. magazine entry number	0.5	0.6	1.0	-0.8	-0.8	-0.8	1.0	0.7	-0.5
Pavlov. Cond. intertrial magazine entries	0.9	1.1	1.4	1.2	1.2	1.2	-1.2	-0.7	0.7
Pavlov. Cond. lever-magazine prob. diff.	0.7	0.9	1.0	1.0	1.0	1.0	-1.0	-1.0	0.8
Pavlov. Cond. response bias	0.6	0.8	1.0	0.9	0.9	0.9	-1.0	-0.9	0.8
Pavlov. Cond. lever latency	1.6	2.1	2.9	1.5	1.5	1.5	-1.7	-1.4	0.9
Pavlov. Cond. magazine entry latency	0.4	0.5	0.8	0.7	0.7	0.7	-0.6	-0.5	0.9
Pavlov. Cond. change in total contacts	0.4	0.6	1.0	-0.8	-0.8	-0.8	1.0	0.7	-0.4
Pavlov. Cond. index score	0.4	0.5	0.7	-0.6	-0.6	-0.6	0.8	0.8	-0.4
Pavlov. Cond. latency score	0.1	0.2	0.3	-0.4	-0.4	-0.4	0.6	0.5	-0.2
Pavlov. Cond. lever contacts	1.1	1.5	2.2	-1.3	-1.3	-1.3	1.5	1.2	-0.8
Pavlov. Cond. magazine entry number	0.0	0.0	0.1	0.0	0.0	0.0	-0.2	-0.3	-0.2
Pavlov. Cond. intertrial magazine entries	1.6	2.0	2.5	1.4	1.4	1.4	-1.6	-1.3	1.3
Pavlov. Cond. lever-magazine prob. diff.	0.5	0.6	0.9	-0.8	-0.8	-0.8	1.0	0.9	-0.5
Pavlov. Cond. response bias	0.8	1.1	1.5	-1.0	-1.0	-1.0	1.2	1.2	-0.7
Time in closed arm before self-admin	2.8	3.2	3.8	-2.0	-2.0	-2.0	1.8	1.6	-1.4
Time in closed arm after self-admin	3.0	3.1	3.9	-1.9	-1.9	-1.9	1.6	2.0	-0.9
Time in open arm before self-admin	0.5	0.6	0.8	0.8	0.8	0.8	-0.7	-0.6	0.9
Time in open arm after self-admin	0.5	0.5	1.1	0.5	0.5	0.5	-0.5	-1.0	1.0
Bone: periosteal estimation	0.3	0.6	1.2	-0.8	-0.8	-0.8	0.6	0.3	-1.1
Bone: periosteal perimeter	0.8	1.4	1.8	-1.3	-1.3	-1.3	1.1	0.6	-1.0
Bone: post-yield work	0.5	0.7	0.9	-1.0	-1.0	-1.0	1.0	0.7	-0.4
Progressive ratio test 1 active lever presses	1.0	1.0	1.3	1.1	1.1	1.1	-1.0	-0.6	0.8
Progressive ratio test 1 breakpoint	1.1	1.2	1.4	1.2	1.2	1.2	-1.1	-0.7	1.0
Progressive ratio test 1 inactive lever presses	0.2	0.3	0.4	-0.5	-0.5	-0.5	0.6	0.6	-0.0
Progressive ratio test 2 active lever presses	1.2	1.3	1.8	1.3	1.3	1.3	-1.3	-0.8	0.4
Progressive ratio test 2 breakpoint	0.7	0.7	1.1	1.0	1.0	1.0	-1.0	-0.5	0.2
Progressive ratio test 2 inactive lever presses	0.0	0.0	0.1	0.2	0.2	0.2	-0.1	0.2	0.1
Incentive Sensitization - Responses	0.2	0.2	0.4	0.5	0.5	0.5	-0.6	-0.2	-0.5
Incentive Sensitization - Breakpoint	0.1	0.1	0.5	0.3	0.3	0.3	-0.4	0.0	-0.7
Sum of active levers in priming session hrs 5-6	6.1	5.9	6.6	2.6	2.6	2.6	-2.6	-2.4	1.8
Progressive ratio	0.3	0.3	0.7	-0.6	-0.6	-0.6	0.8	0.5	-0.1
Food seeking constrained by brief footshock	0.2	0.2	1.2	0.0	0.0	0.0	0.3	-0.2	-1.1
Seeking ratio, punishment vs. effort	0.8	1.0	1.3	1.1	1.1	1.1	-1.1	-1.0	0.1
Retroperitoneal fat weight	0.3	0.9	1.9	-0.8	-0.8	-0.8	0.7	1.0	-1.4
Reaction time number correct	1.0	1.4	2.0	-1.4	-1.4	-1.4	1.4	0.4	0.1
Reaction time mean minus median	1.9	2.6	3.1	1.6	1.6	1.6	-1.6	-1.8	1.2
Reaction time mean minus median AUC	2.9	3.7	4.2	2.1	2.1	2.1	-2.1	-1.9	1.4
Reaction time num false alarms	0.9	1.2	1.6	1.3	1.3	1.3	-1.1	-0.9	0.6
Reaction time num false alarms AUC	1.0	1.3	1.7	1.3	1.3	1.3	-1.1	-1.0	0.7
Reaction time trials correct on left	1.0	1.4	2.0	-1.4	-1.4	-1.4	1.4	0.4	0.1
Reaction time trials on left	0.9	1.3	1.9	-1.4	-1.4	-1.4	1.4	0.4	0.2
Reaction time mean	1.0	1.4	2.1	1.3	1.3	1.3	-1.5	-1.0	0.5
Reaction time mean AUC	1.2	1.6	2.5	1.4	1.4	1.4	-1.6	-1.1	0.6
Median of all reaction times	0.3	0.5	0.9	0.8	0.8	0.8	-1.0	-0.3	-0.1
Reaction time omissions	0.9	1.2	1.7	1.3	1.3	1.3	-1.1	-0.7	0.6
Reaction time false alarm rate	1.5	2.0	2.9	1.7	1.7	1.7	-1.5	-1.0	0.4
Reaction time premature initiation rate	0.3	0.4	1.1	0.5	0.5	0.5	-0.4	-0.8	1.0
Reaction time premature initiations	0.3	0.4	1.4	-0.2	-0.2	-0.2	0.2	-0.8	1.2
Std. dev. reaction times	1.9	2.7	3.3	1.7	1.7	1.7	-1.8	-1.7	1.0
Reaction time trials completed	0.9	1.3	1.9	-1.4	-1.4	-1.4	1.4	0.4	0.2
Reaction time trials AUC	0.9	1.3	1.9	-1.4	-1.4	-1.4	1.4	0.3	0.2
Run reversals in cocaine runway, females	0.3	0.3	0.4	0.5	0.5	0.5	-0.5	-0.6	0.5
Run reversals in cocaine runway, males	1.5	1.5	1.9	-1.2	-1.2	-1.2	1.3	1.4	-0.8
Latency to leave start box in cocaine runway	6.0	6.4	7.5	-2.7	-2.7	-2.7	2.5	2.4	-2.0
Latency to leave start box in cocaine runway, F	9.0	9.9	11.4	-3.4	-3.4	-3.4	3.2	3.1	-2.4
Latency to leave start box in cocaine runway, M	0.3	0.3	1.0	-0.3	-0.3	-0.3	0.1	0.5	-1.0
Std. dev. time between licks in bursts	0.9	1.0	1.5	-0.9	-0.9	-0.9	0.9	1.1	-1.2
Total sessions with >9 infusions	0.5	0.6	0.7	0.8	0.8	0.8	-0.8	-0.7	-0.4
Short access day 1 total inactive lever presses	0.7	0.8	2.8	0.4	0.4	0.4	-0.3	-1.2	1.7
Short access day 10 total inactive lever presses	0.3	0.3	0.4	-0.7	-0.7	-0.7	0.6	-0.0	0.5
Short access day 1 total infusions	0.1	0.1	0.5	0.1	0.1	0.1	0.1	-0.7	0.2
Short access day 10 total infusions	0.1	0.1	0.2	0.4	0.4	0.4	-0.3	0.3	-0.4
Short access total infusions	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.1	0.0
Short access day 1 locomotion	0.2	0.2	1.1	-0.2	-0.2	-0.2	0.2	0.3	-1.1
Short access day 10 total locomotion	0.9	1.0	1.2	1.1	1.1	1.1	-1.1	-0.6	-0.9
Short access total locomotion	0.3	0.3	1.4	0.4	0.4	0.4	-0.3	0.2	-1.2
One hour access (0.3 mA shock)	0.8	1.0	1.1	1.1	1.1	1.1	-1.0	-0.8	0.9
Compulsive drug intake	7.7	7.8	9.0	2.8	2.8	2.8	-2.7	-2.8	3.0
One hour access (shock baseline)	1.5	1.8	3.4	-1.1	-1.1	-1.1	1.1	1.6	-1.9
Social response proportion	1.9	2.0	2.9	1.5	1.5	1.5	-1.7	-1.3	0.9
Social responses	0.0	0.0	0.1	0.0	0.0	0.0	-0.0	-0.3	0.3
Social time	0.0	0.1	0.1	-0.3	-0.3	-0.3	0.2	-0.1	0.3
Soleus weight	1.3	3.8	4.3	-2.0	-2.0	-2.0	1.9	2.1	-1.8
Bone: stiffness	0.0	0.1	0.2	-0.2	-0.2	-0.2	0.0	-0.3	-0.4
Tibialis anterior weight	0.2	0.7	1.9	0.5	0.5	0.5	-0.4	-1.4	1.1
Time to tail flick, vehicle, before self-admin	1.6	1.6	2.2	1.2	1.2	1.2	-1.1	-1.3	1.5
Time to tail flick, vehicle, after self-admin	0.7	0.7	1.1	-1.0	-1.0	-1.0	0.7	0.6	-0.4
Time to tail flick, test, before self-admin	0.4	0.4	0.6	-0.6	-0.6	-0.6	0.8	0.7	-0.2
Time to tail flick, test, after self-admin	0.3	0.3	0.5	-0.6	-0.6	-0.6	0.7	0.4	0.0
Delta time to tail flick, vehicle, before/after SA	3.1	3.1	3.9	-2.0	-2.0	-2.0	1.7	1.6	-1.3
Delta time to tail flick, test, before/after SA	0.4	0.3	0.4	0.6	0.6	0.6	-0.5	-0.6	0.5
Tibia length	0.5	1.3	1.6	-1.3	-1.3	-1.3	1.2	0.9	-0.9
Ambulatory time before self-admin	1.4	1.4	2.1	1.3	1.3	1.3	-1.4	-1.0	0.5
Ambulatory time after self-admin	0.3	0.3	1.3	-0.5	-0.5	-0.5	0.4	0.1	-1.1
Bone: tissue strength	0.7	0.6	1.0	-0.9	-0.9	-0.9	1.0	0.4	-0.2
Total heroin consumption	1.0	1.2	2.2	1.0	1.0	1.0	-0.9	-1.0	1.5
Bone: trabecular number	0.2	0.4	1.4	-0.3	-0.3	-0.3	0.1	0.8	-1.2
Bone: trabecular spacing	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.1	0.2
Bone: trabecular thickness	2.8	3.3	4.4	-2.1	-2.1	-2.1	1.9	1.2	-1.4
Bone: trabecular tissue density	0.0	0.1	0.2	0.2	0.2	0.2	-0.1	-0.4	0.4
Water consumed over 24 hours	0.1	0.1	0.4	0.1	0.1	0.1	-0.1	-0.5	0.7
Number of responses in last shaping day	1.6	1.7	2.2	-1.4	-1.4	-1.4	1.5	1.3	-0.0