LOC102550334

Models

All models for this gene with cis-heritability P-value <0.01 were tested and are shown here. In each tissue, a gene can have zero, one, or multiple RNA phenotypes for each RNA modality. After the heritability statistics, subsequent columns show cross-validation performance (R2 and P-value) of each modeling method. The best-performing method for each models is used for TWAS.

# Tissue Modality RNA phenotype h2 h2 SE h2 P xQTL R2 BLUP R2 ENET R2 LASSO R2 xQTL P BLUP P ENET P LASSO P
1 Adipose alternative TSS XR_005490503.1 0.08 0.06 8.1e-03 0 0.01 -0 0.01 2.4e-01 1.0e-02 4.1e-01 5.7e-02
2 Adipose alternative TSS XR_005490504.1 0.06 0.04 8.8e-04 0 0.03 0.01 0.02 8.1e-02 3.8e-04 2.0e-02 3.7e-03
3 Adipose gene expression LOC102550334 0.19 0.09 2.5e-07 0.03 0.06 0.06 0.06 5.4e-04 2.2e-07 3.3e-07 3.7e-07
4 Brain gene expression LOC102550334 0.03 0.02 4.5e-03 0.03 0.01 0.01 0.01 1.4e-03 1.3e-02 8.5e-02 2.0e-02

Trait associations

The numbered columns correspond to the numbered models in the table above. They contain the TWAS Z-score for each trait-model pair. Colors indicate strength of Z-scores: cells with lower negative Z-scores are darker blue, cells with higher positive Z-scores are darker red. Significant associations have white and bolded text.

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bone: apparent density0.10.20.40.60.0-0.60.2
Area under the delay curve0.20.20.60.4-0.40.3-0.8
BMI with tail1.24.05.81.5-2.41.8-2.2
BMI without tail2.75.66.92.2-2.62.6-2.0
Body weight3.112.816.32.8-4.03.3-4.0
Weight adjusted by age0.30.30.9-0.7-0.0-0.0-0.9
Bone surface1.22.14.22.0-1.30.8-1.3
Bone volume1.93.35.92.4-1.81.2-1.6
Breakpoint value in progressive ratio session0.10.10.3-0.20.2-0.10.6
Number of licking bursts0.30.40.90.3-0.60.4-0.9
Context. condit. distance diff. score0.10.10.20.3-0.40.1-0.4
Locomotion velocity, session 10.10.10.20.3-0.20.40.1
Locomotion distance, session 10.30.40.60.7-0.50.80.2
Locomotion velocity, session 20.30.30.80.50.00.60.9
Locomotion distance, session 20.30.41.30.40.00.51.1
Locomotion velocity, session 30.40.41.5-0.30.30.21.2
Locomotion distance, session 30.00.10.10.3-0.20.2-0.1
Stereotopy head waving bouts, day 36.57.710.4-2.62.9-2.33.2
Stereotopy head waving duration, day 32.73.25.3-1.51.8-1.32.3
Locomotion velocity, session 70.10.10.30.00.2-0.40.6
Locomotion distance, session 71.21.52.31.5-1.21.1-1.0
Stereotopy head waving bouts, day 73.03.43.8-1.71.8-1.81.9
Stereotopy head waving duration, day 76.17.57.9-2.72.8-2.72.7
Locomotion velocity, session 80.10.10.30.4-0.30.50.0
Locomotion distance, session 80.50.71.21.1-0.71.10.2
Degree of sensitization distance0.70.71.01.0-0.80.9-0.5
Degree of sensitization stereotypy1.21.31.5-1.11.1-1.21.2
Conditioned locomotion0.00.00.10.3-0.10.20.1
Cocaine response after cond. corrected0.30.41.10.5-0.50.2-1.0
Cocaine response after cond. not corrected0.50.61.50.6-0.60.3-1.2
Cocaine response before conditioning0.00.10.10.2-0.10.40.2
Saline control response0.60.81.30.7-1.11.1-0.5
Bone: connectivity density0.81.32.3-0.21.1-1.31.5
Bone: cortical apparent density2.33.04.1-1.81.7-1.32.0
Bone: cortical area3.34.96.62.5-2.32.6-1.2
Bone: cortical porosity3.43.84.62.2-2.01.9-1.7
Bone: cortical porosity5.05.46.22.5-2.42.2-2.2
Bone: cortical thickness0.61.03.5-0.60.50.11.9
Bone: cortical thickness1.41.74.5-0.81.1-0.62.1
Bone: cortical tissue density2.33.04.0-1.81.7-1.32.0
Condit. Reinf. active minus inactive responses5.46.17.12.5-2.52.7-2.2
Condit. Reinf. active-inactive response ratio0.60.71.30.6-0.80.6-1.1
Condit. Reinf. active responses5.76.98.62.9-2.72.9-2.0
Condit. Reinf. inactive responses1.92.23.51.9-1.51.8-0.5
Incentive salience index mean2.63.13.81.8-1.81.9-1.4
Condit. Reinf. lever presses0.10.20.30.4-0.50.5-0.1
Condit. Reinf. active minus inactive responses5.46.78.93.0-2.52.7-2.1
Condit. Reinf. active-inactive response ratio3.83.94.92.2-1.91.8-2.0
Condit. Reinf. active responses7.09.713.03.6-3.13.3-2.3
Condit. Reinf. inactive responses2.12.64.32.0-1.52.1-0.3
Condit. Reinf. lever presses4.56.17.32.7-2.52.7-1.8
Condit. Reinf. lever reinforcers received6.59.212.13.5-3.03.2-2.3
Conditioned reinforcement - actives2.12.12.6-1.21.6-1.41.6
Conditioned reinforcement - inactives0.30.30.40.6-0.60.6-0.2
Conditioned locomotion1.72.02.41.6-1.41.2-1.5
Patch foraging indifference point 0 sec7.011.317.53.4-3.44.2-2.0
Patch foraging indifference point AUC1.01.11.51.0-1.01.2-1.0
Delay disc. indifference point, 0s delay0.20.20.5-0.40.2-0.7-0.5
Delay disc. indifference point, 16s delay0.40.41.00.2-0.50.3-1.0
Delay disc. indifference point, 2s delay0.10.10.40.1-0.10.2-0.7
Delay disc. indifference point, 24s delay1.71.72.41.5-1.41.1-1.0
Delay disc. indifference point, 4s delay0.10.10.1-0.20.2-0.3-0.3
Delay disc. indifference point, 8s delay0.40.50.7-0.80.6-0.70.5
Indifference point function ln k0.50.72.60.20.40.11.6
Indifference point function log k0.50.72.60.20.40.11.6
Patch foraging total patch changes 0 sec6.210.116.23.2-3.24.0-1.8
Patch foraging total patch changes 12 sec5.46.99.22.6-2.63.0-2.2
Patch foraging total patch changes 18 sec3.34.37.31.9-2.12.7-1.3
Patch foraging total patch changes 24 sec7.28.811.93.3-3.13.5-1.8
Patch foraging total patch changes 6 sec10.415.520.03.9-4.04.5-3.3
Patch foraging time to switch 0 sec0.30.40.8-0.60.3-0.9-0.6
Patch foraging water rate 0 sec1.82.85.01.7-1.62.2-0.9
Patch foraging water rate 12 sec0.20.30.90.4-0.51.00.1
Patch foraging water rate 18 sec0.30.41.30.10.2-0.11.2
Patch foraging water rate 24 sec0.30.41.2-0.20.6-0.21.1
Patch foraging water rate 6 sec0.20.30.9-0.40.5-0.20.9
Seeking ratio, delayed vs. immediate footshock1.31.53.00.7-1.11.1-1.7
Distance traveled before self-admin0.20.20.5-0.40.2-0.2-0.7
Distance traveled after self-admin0.20.31.00.1-0.20.2-1.0
Extensor digitorum longus weight0.41.73.0-1.70.7-1.7-0.5
Bone: elastic displacement0.80.92.4-0.60.8-0.31.6
Bone: elastic work0.10.10.20.1-0.10.20.4
Bone: endosteal estimation11.725.632.15.2-4.94.3-5.7
Bone: endosteal perimeter13.427.832.35.7-5.24.6-5.5
Epididymis fat weight0.92.26.6-0.0-1.40.3-2.6
Delta time in closed arm before/after self-admin0.20.20.6-0.10.4-0.80.3
Delta time in open arm before/after self-admin1.81.73.3-1.11.3-0.91.8
Diff in mean of infusions in LGA sessions0.10.10.2-0.2-0.2-0.2-0.5
Delay discount exponential model param0.50.61.0-0.70.7-0.51.0
Extinction: sum of active levers before priming0.20.20.40.5-0.50.1-0.6
Active lever presses in extinction session 60.20.20.20.5-0.50.2-0.5
Bone: final force1.11.82.51.6-1.41.3-1.1
Bone: final moment1.11.72.51.6-1.31.3-1.0
Food consumed during 24 hour testing period0.10.10.1-0.3-0.10.30.3
Glucose0.00.10.2-0.20.2-0.4-0.2
Heart weight5.47.78.42.9-2.92.8-2.4
Delay discount hyperbolic model param0.40.40.8-0.50.6-0.50.9
Intermittent access intake day 1-15 change0.80.82.20.4-0.80.4-1.5
Intermittent access intake escalation0.60.61.90.3-0.70.1-1.4
Intermittent access intake escalation 21.11.12.40.9-1.00.4-1.5
Intermitt. access day 1 inactive lever presses1.51.62.51.6-1.51.3-0.4
Intermitt. access day 15 inactive lever presses0.10.10.3-0.0-0.4-0.1-0.6
Intermitt. access escalation Index0.40.40.5-0.70.7-0.70.2
Intermittent access day 1 total infusions0.20.20.40.2-0.10.50.7
Intermittent access day 15 total infusions0.80.91.20.8-1.00.8-1.1
Intermittent access terminal intake (last 3 days)0.91.01.21.0-1.10.8-1.1
Intermittent access total infusions0.40.40.70.7-0.70.8-0.1
Intermittent access day 1 locomotion1.71.82.31.4-1.51.3-1.0
Intermittent access day 15 total locomotion2.12.22.91.7-1.61.3-1.2
Intermittent access total locomotion4.14.75.92.3-2.42.2-1.7
Intermittent access standard deviation1.41.52.01.1-1.30.9-1.4
Left kidney weight0.82.33.01.7-1.71.7-0.7
Right kidney weight1.13.14.21.8-2.01.3-1.8
Cocaine induced anxiety0.30.40.7-0.40.7-0.80.4
Post-drug Anxiety0.70.81.5-0.90.9-1.20.0
Baseline Anxiety0.70.81.5-1.21.0-0.80.3
Tail length0.92.73.71.3-1.71.6-1.9
Length with tail1.34.87.11.7-2.32.0-2.7
Length without tail0.10.20.5-0.3-0.1-0.4-0.7
Times rat made contact with spout0.30.40.60.4-0.70.8-0.6
Lifetime Intake0.60.61.10.9-0.81.10.2
Liver weight, left0.30.50.7-0.70.8-0.60.7
Liver weight, right1.11.92.4-1.61.4-1.11.4
Locomotor activity2.23.64.82.2-2.12.1-0.9
Locomotor testing distance2.84.66.32.5-2.22.5-1.0
Locomotor testing rearing1.82.74.01.7-1.82.0-1.0
Locomotion in novel chamber0.20.30.5-0.70.4-0.6-0.4
Locomotion in novel chamber post-restriction0.00.00.1-0.30.20.10.2
Fecal boli incidents, locomotor time 10.30.30.90.5-0.50.1-0.9
Change in fecal boli incidents, locomotor task0.10.10.2-0.40.30.1-0.2
Time >=10cm from walls, locomotor time 10.90.92.2-0.80.9-0.51.5
Bouts of movement, locomotor time 10.10.10.20.1-0.40.1-0.5
Total resting periods, locomotor time 10.10.10.2-0.1-0.2-0.3-0.4
Rest time, locomotor task time 10.60.61.1-1.00.8-1.00.2
Distance moved, locomotor task time 10.10.10.2-0.50.20.00.5
Vertical activity count, locomotor time 10.10.10.1-0.30.10.20.4
Time >=10cm from walls, locomotor time 21.11.12.3-1.51.0-0.90.6
Bouts of movement, locomotor time 20.10.10.30.1-0.50.3-0.2
Total resting periods, locomotor time 20.20.20.30.3-0.60.4-0.2
Rest time, locomotor task time 23.23.74.9-1.92.0-2.21.3
Distance moved, locomotor task time 20.50.61.1-1.10.6-0.60.7
Vertical activity count, locomotor time 20.30.40.60.4-0.80.8-0.3
Light reinforcement 10.20.30.80.2-0.10.60.9
Light reinforcement 20.00.00.1-0.20.1-0.10.2
Bone: marrow area11.124.030.85.1-4.84.1-5.6
Bone: maximum diameter4.37.910.33.2-2.72.7-2.6
Bone: maximum force2.74.76.32.5-2.22.0-1.9
Bone: maximum moment2.74.76.42.5-2.22.1-1.8
Mean time between licks in bursts0.71.02.20.8-1.10.3-1.5
Mean num. licks in bursts0.10.10.30.00.10.10.6
Cd content in liver2.83.14.6-1.71.8-2.11.2
Co content in liver0.30.30.7-0.60.3-0.8-0.4
Cu content in liver0.00.00.00.2-0.00.1-0.1
Fe content in liver0.10.10.30.5-0.10.20.5
K content in liver0.30.30.5-0.40.7-0.30.6
Mg content in liver2.42.53.2-1.31.8-1.41.7
Mn content in liver1.41.62.4-0.81.4-1.11.6
Na content in liver0.60.60.8-0.70.9-0.70.8
Rb content in liver1.62.02.6-1.51.6-1.21.4
Se content in liver1.31.51.9-1.41.3-1.11.2
Sr content in liver1.61.51.81.2-1.31.2-1.0
Zn content in liver0.30.30.9-0.20.6-0.21.0
Bone: minimum diameter13.024.227.45.2-4.94.6-4.9
Time in familiar zone, hab. session 11.51.42.11.1-1.21.0-1.4
Time in novel zone, hab. session 10.60.61.2-0.60.7-0.51.1
Total zone transitions, hab. session 10.30.40.60.6-0.80.7-0.2
Total locomotion distance, hab. session 10.20.30.60.5-0.50.80.3
Locomotion velocity, hab. session 10.10.10.30.3-0.30.60.3
Time in familiar zone, hab. session 22.12.12.31.5-1.51.5-1.4
Time in novel zone, hab. session 23.33.33.7-1.71.9-1.71.9
Total zone transitions, hab. session 20.10.20.30.4-0.50.50.3
Total locomotion distance, hab. session 20.10.20.6-0.1-0.00.40.8
Locomotion velocity, hab. session 20.30.41.2-0.50.30.01.1
Novel to familiar place preference ratio3.83.94.52.0-2.01.8-2.1
Novelty place preference2.52.63.01.6-1.61.4-1.7
Time in novel zone, NPP test2.42.52.81.7-1.61.5-1.6
Total zone transitions, NPP test0.40.61.10.6-0.30.91.1
Total locomotion distance, NPP test0.40.62.00.10.20.61.4
Locomotion velocity, NPP test0.30.51.30.1-0.10.81.1
Intraocular pressure1.62.23.11.6-1.51.8-1.0
Delta distance traveled before/after self-admin0.20.20.5-0.30.4-0.10.7
Delta ambulatory time before/after self-admin0.00.00.10.3-0.10.1-0.2
Parametrial fat weight0.71.42.0-1.11.3-1.40.7
Pavlov. Cond. lever latency1.31.72.1-1.11.5-1.41.2
Pavlov. Cond. magazine entry latency1.82.32.51.5-1.61.5-1.5
Pavlov. Cond. change in total contacts2.42.53.01.5-1.71.5-1.6
Pavlov. Cond. index score1.92.52.81.5-1.71.5-1.6
Pavlov. Cond. latency score1.92.52.91.4-1.71.5-1.7
Pavlov. Cond. lever contacts1.11.31.80.9-1.31.0-1.2
Pavlov. Cond. magazine entry number0.91.21.5-1.01.1-0.91.2
Pavlov. Cond. intertrial magazine entries7.18.510.93.1-2.93.3-2.2
Pavlov. Cond. lever-magazine prob. diff.1.92.32.71.5-1.61.5-1.4
Pavlov. Cond. response bias1.01.21.41.1-1.21.1-1.1
Pavlov. Cond. lever latency1.52.03.3-1.81.3-1.70.5
Pavlov. Cond. magazine entry latency0.00.00.00.1-0.00.10.0
Pavlov. Cond. change in total contacts1.11.52.21.5-1.11.4-0.7
Pavlov. Cond. index score1.41.82.61.6-1.31.4-0.8
Pavlov. Cond. latency score1.41.72.51.6-1.21.5-0.7
Pavlov. Cond. lever contacts1.01.42.21.5-1.11.4-0.3
Pavlov. Cond. magazine entry number0.00.00.0-0.20.1-0.1-0.0
Pavlov. Cond. intertrial magazine entries0.30.40.70.8-0.60.5-0.5
Pavlov. Cond. lever-magazine prob. diff.1.31.62.41.6-1.21.3-0.8
Pavlov. Cond. response bias0.70.91.61.3-0.91.1-0.4
Time in closed arm before self-admin0.20.20.60.1-0.30.80.1
Time in closed arm after self-admin0.10.10.2-0.1-0.10.1-0.5
Time in open arm before self-admin0.40.41.50.0-0.5-0.2-1.2
Time in open arm after self-admin0.00.00.20.0-0.20.0-0.4
Bone: periosteal estimation10.421.625.45.0-4.64.4-4.5
Bone: periosteal perimeter8.614.417.24.1-3.83.4-3.8
Bone: post-yield work2.83.84.82.1-2.01.4-2.2
Progressive ratio test 1 active lever presses0.30.40.80.3-0.50.90.5
Progressive ratio test 1 breakpoint0.70.71.60.7-0.81.30.2
Progressive ratio test 1 inactive lever presses2.42.63.81.8-1.81.9-0.7
Progressive ratio test 2 active lever presses0.00.00.10.0-0.10.30.3
Progressive ratio test 2 breakpoint0.00.00.1-0.00.00.20.4
Progressive ratio test 2 inactive lever presses0.20.20.30.5-0.50.6-0.2
Incentive Sensitization - Responses0.10.10.2-0.40.4-0.30.0
Incentive Sensitization - Breakpoint0.20.20.3-0.50.6-0.40.1
Sum of active levers in priming session hrs 5-60.30.30.40.4-0.60.5-0.6
Progressive ratio0.20.20.4-0.50.4-0.7-0.1
Food seeking constrained by brief footshock0.10.10.40.4-0.3-0.0-0.6
Seeking ratio, punishment vs. effort0.20.30.40.6-0.50.6-0.1
Retroperitoneal fat weight1.13.56.41.1-2.21.2-2.5
Reaction time number correct0.30.50.9-0.40.8-0.51.0
Reaction time mean minus median0.91.22.0-1.40.9-1.3-0.4
Reaction time mean minus median AUC0.60.81.1-1.11.0-1.00.3
Reaction time num false alarms5.87.910.13.2-2.93.0-2.0
Reaction time num false alarms AUC5.67.810.03.2-2.83.0-2.1
Reaction time trials correct on left0.30.50.9-0.40.8-0.51.0
Reaction time trials on left0.30.50.8-0.40.8-0.50.9
Reaction time mean1.11.62.2-1.51.3-1.40.5
Reaction time mean AUC1.41.82.6-1.61.4-1.50.6
Median of all reaction times0.91.21.5-1.21.2-1.20.7
Reaction time omissions0.20.30.8-0.50.5-0.90.2
Reaction time false alarm rate4.96.98.12.8-2.72.7-2.2
Reaction time premature initiation rate3.75.05.62.3-2.42.2-2.1
Reaction time premature initiations1.82.63.21.8-1.61.7-1.3
Std. dev. reaction times1.31.82.8-1.61.3-1.70.2
Reaction time trials completed0.30.50.8-0.40.8-0.50.9
Reaction time trials AUC0.40.61.0-0.60.9-0.61.0
Run reversals in cocaine runway, females0.70.71.5-0.8-0.2-0.8-1.2
Run reversals in cocaine runway, males0.10.10.3-0.30.2-0.3-0.5
Latency to leave start box in cocaine runway0.90.91.6-1.10.9-0.31.3
Latency to leave start box in cocaine runway, F0.10.10.2-0.30.10.30.5
Latency to leave start box in cocaine runway, M2.22.13.0-1.71.5-1.01.5
Std. dev. time between licks in bursts0.70.81.1-1.00.8-1.00.9
Total sessions with >9 infusions0.40.41.00.6-0.51.00.3
Short access day 1 total inactive lever presses0.00.10.20.1-0.10.20.4
Short access day 10 total inactive lever presses0.80.81.31.1-1.10.8-0.5
Short access day 1 total infusions0.40.50.90.4-0.20.91.0
Short access day 10 total infusions1.82.03.31.5-1.61.8-0.6
Short access total infusions1.11.32.51.3-1.01.60.3
Short access day 1 locomotion0.60.71.10.9-0.91.0-0.2
Short access day 10 total locomotion3.94.35.42.0-2.32.0-1.9
Short access total locomotion3.13.34.21.8-2.12.0-1.2
One hour access (0.3 mA shock)0.91.11.81.3-1.01.2-0.2
Compulsive drug intake1.01.11.31.2-1.00.9-1.1
One hour access (shock baseline)0.00.00.10.2-0.10.00.3
Social response proportion0.60.71.80.6-0.60.1-1.3
Social responses2.22.83.71.9-1.81.7-1.2
Social time0.40.62.00.4-0.5-0.1-1.4
Soleus weight0.61.62.61.2-1.40.8-1.6
Bone: stiffness1.42.22.61.6-1.51.2-1.6
Tibialis anterior weight0.20.72.10.1-0.8-0.0-1.4
Time to tail flick, vehicle, before self-admin0.30.30.7-0.60.4-0.9-0.3
Time to tail flick, vehicle, after self-admin0.40.41.60.3-0.3-0.1-1.3
Time to tail flick, test, before self-admin1.51.55.30.4-0.70.2-2.3
Time to tail flick, test, after self-admin0.90.91.21.1-0.90.7-1.0
Delta time to tail flick, vehicle, before/after SA0.00.00.10.3-0.00.1-0.3
Delta time to tail flick, test, before/after SA0.30.30.70.8-0.40.60.4
Tibia length0.61.63.00.6-1.31.1-1.7
Ambulatory time before self-admin0.20.20.3-0.60.3-0.1-0.5
Ambulatory time after self-admin0.20.20.80.2-0.20.2-0.9
Bone: tissue strength1.51.53.1-1.01.2-0.71.8
Total heroin consumption0.10.10.20.4-0.40.2-0.2
Bone: trabecular number0.30.50.80.20.6-0.80.9
Bone: trabecular spacing0.10.10.3-0.50.00.1-0.2
Bone: trabecular thickness1.51.82.91.7-1.31.2-1.0
Bone: trabecular tissue density0.10.10.3-0.50.2-0.20.0
Water consumed over 24 hours0.50.61.4-0.70.5-0.31.2
Number of responses in last shaping day0.10.10.1-0.3-0.20.3-0.2